NT5E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)6.64633944
2skin morphogenesis (GO:0043589)5.97932477
3Golgi transport vesicle coating (GO:0048200)5.02307041
4COPI coating of Golgi vesicle (GO:0048205)5.02307041
5endodermal cell differentiation (GO:0035987)4.98457475
6substrate-dependent cell migration (GO:0006929)4.90910177
7mesodermal cell differentiation (GO:0048333)4.89104549
8chondrocyte proliferation (GO:0035988)4.77756269
9L-phenylalanine catabolic process (GO:0006559)4.58425807
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.58425807
11protein localization to endosome (GO:0036010)4.57342954
12cell-substrate junction assembly (GO:0007044)4.36563801
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.35829060
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.35730448
15L-phenylalanine metabolic process (GO:0006558)4.35730448
16regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.30273315
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.27523500
18protein retention in ER lumen (GO:0006621)4.20994505
19tryptophan metabolic process (GO:0006568)4.18124717
20cysteine metabolic process (GO:0006534)4.13580042
21aromatic amino acid family catabolic process (GO:0009074)4.13418446
22high-density lipoprotein particle remodeling (GO:0034375)4.11512152
23drug catabolic process (GO:0042737)4.05326409
24barbed-end actin filament capping (GO:0051016)4.02253580
25type B pancreatic cell proliferation (GO:0044342)3.99465401
26tryptophan catabolic process (GO:0006569)3.91468007
27indole-containing compound catabolic process (GO:0042436)3.91468007
28indolalkylamine catabolic process (GO:0046218)3.91468007
29cellular response to vitamin D (GO:0071305)3.90470898
30cellular response to vitamin (GO:0071295)3.88842305
31membrane raft organization (GO:0031579)3.87784533
32collagen fibril organization (GO:0030199)3.84296612
33muscle cell migration (GO:0014812)3.83849413
34phospholipid efflux (GO:0033700)3.80299585
35reverse cholesterol transport (GO:0043691)3.77540841
36sequestering of extracellular ligand from receptor (GO:0035581)3.76928611
37kynurenine metabolic process (GO:0070189)3.75488947
38protein maturation by protein folding (GO:0022417)3.74095499
39cellular glucuronidation (GO:0052695)3.73167597
40regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.72265398
41dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.68096108
42actin filament depolymerization (GO:0030042)3.67828277
43wound healing, spreading of epidermal cells (GO:0035313)3.62359721
44glyoxylate metabolic process (GO:0046487)3.61139467
45regulation of cholesterol esterification (GO:0010872)3.58900289
46urea metabolic process (GO:0019627)3.58580870
47urea cycle (GO:0000050)3.58580870
48peptidyl-glutamic acid carboxylation (GO:0017187)3.56972371
49protein carboxylation (GO:0018214)3.56972371
50positive regulation of blood vessel endothelial cell migration (GO:0043536)3.56463640
51endothelial cell morphogenesis (GO:0001886)3.55599950
52alpha-linolenic acid metabolic process (GO:0036109)3.55409300
53protein heterotrimerization (GO:0070208)3.54731094
54kidney mesenchyme development (GO:0072074)3.54509943
55drug transmembrane transport (GO:0006855)3.54295645
56negative regulation of sterol transport (GO:0032372)3.53272653
57negative regulation of cholesterol transport (GO:0032375)3.53272653
58negative regulation of chondrocyte differentiation (GO:0032331)3.53214409
59fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.49881717
60regulation of cholesterol homeostasis (GO:2000188)3.48308423
61extracellular fibril organization (GO:0043206)3.46086063
62tyrosine metabolic process (GO:0006570)3.44787129
63homocysteine metabolic process (GO:0050667)3.42060728
64negative regulation of anoikis (GO:2000811)3.41604742
65lysine metabolic process (GO:0006553)3.40293541
66lysine catabolic process (GO:0006554)3.40293541
67protein hydroxylation (GO:0018126)3.39276976
68regulation of metalloenzyme activity (GO:0048552)3.37089931
69sulfur amino acid catabolic process (GO:0000098)3.36765687
70amino-acid betaine metabolic process (GO:0006577)3.36387496
71cell migration involved in sprouting angiogenesis (GO:0002042)3.35868108
72retina vasculature morphogenesis in camera-type eye (GO:0061299)3.35808791
73basement membrane organization (GO:0071711)3.35684395
74cholesterol efflux (GO:0033344)3.30577786
75negative regulation of fibrinolysis (GO:0051918)3.30253589
76urate metabolic process (GO:0046415)3.29764830
77uronic acid metabolic process (GO:0006063)3.28977306
78glucuronate metabolic process (GO:0019585)3.28977306
79plasma lipoprotein particle assembly (GO:0034377)3.28681823
80protein-lipid complex remodeling (GO:0034368)3.28144252
81macromolecular complex remodeling (GO:0034367)3.28144252
82plasma lipoprotein particle remodeling (GO:0034369)3.28144252
83regulation of triglyceride catabolic process (GO:0010896)3.22019259
84acylglycerol homeostasis (GO:0055090)3.21001253
85triglyceride homeostasis (GO:0070328)3.21001253
86peptidyl-proline hydroxylation (GO:0019511)3.19593439
87exogenous drug catabolic process (GO:0042738)3.19109496
88nitrogen cycle metabolic process (GO:0071941)3.18076883
89mesenchymal-epithelial cell signaling (GO:0060638)3.17522358
90collagen metabolic process (GO:0032963)3.16596268
91positive regulation of osteoblast proliferation (GO:0033690)3.15954930
92ethanol oxidation (GO:0006069)3.14993970
93positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.14809464
94plasma lipoprotein particle clearance (GO:0034381)3.11201776
95heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.10617861
96flavonoid metabolic process (GO:0009812)3.10057737
97phospholipid homeostasis (GO:0055091)3.09883263
98wound healing, spreading of cells (GO:0044319)3.08861749
99fibril organization (GO:0097435)3.08794870
100bile acid biosynthetic process (GO:0006699)3.07887423
101serine family amino acid catabolic process (GO:0009071)3.07864948
102fibrinolysis (GO:0042730)3.07748204
103stress fiber assembly (GO:0043149)3.07536640
104drug transport (GO:0015893)3.06176512
105indolalkylamine metabolic process (GO:0006586)3.04463347
106aromatic amino acid family metabolic process (GO:0009072)3.03966870
107complement activation, alternative pathway (GO:0006957)3.02794272
108protein-lipid complex assembly (GO:0065005)3.01458815
109extracellular matrix assembly (GO:0085029)3.00457169
110regulation of fibrinolysis (GO:0051917)3.00226097
111regulation of extracellular matrix disassembly (GO:0010715)2.98337483
112regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.96727673
113hyaluronan catabolic process (GO:0030214)2.96438809
114extracellular matrix disassembly (GO:0022617)2.95361070
115regulation of protein activation cascade (GO:2000257)2.93790030
116positive regulation of endothelial cell apoptotic process (GO:2000353)2.93718349
117negative regulation of lipase activity (GO:0060192)2.93601674
118desmosome organization (GO:0002934)2.93371936
119vascular endothelial growth factor signaling pathway (GO:0038084)2.91965589
120benzene-containing compound metabolic process (GO:0042537)2.91840318
121multicellular organismal macromolecule metabolic process (GO:0044259)2.91410879
122mammary gland epithelial cell proliferation (GO:0033598)2.89893560
123regulation of anoikis (GO:2000209)2.89624372
124collagen catabolic process (GO:0030574)2.89541091
125endocardial cushion development (GO:0003197)2.89303501
126positive regulation of lipoprotein lipase activity (GO:0051006)2.87500813
127positive regulation of triglyceride lipase activity (GO:0061365)2.87500813
128apoptotic cell clearance (GO:0043277)2.87171431
129COPII vesicle coating (GO:0048208)2.85674723
130regulation of plasminogen activation (GO:0010755)2.85610226
131very-low-density lipoprotein particle assembly (GO:0034379)2.84364426
132bile acid metabolic process (GO:0008206)2.83995662
133response to gravity (GO:0009629)2.83310383
134lipoprotein metabolic process (GO:0042157)2.82916658
135negative regulation of smooth muscle cell migration (GO:0014912)2.82727440
136carnitine metabolic process (GO:0009437)2.81828601
137virion attachment to host cell (GO:0019062)2.81130437
138adhesion of symbiont to host cell (GO:0044650)2.81130437
139retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.80968547
140sprouting angiogenesis (GO:0002040)2.80876325
141antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.80051396
142antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.80051396
143positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.79897922
144drug metabolic process (GO:0017144)2.78390217
145positive regulation of astrocyte differentiation (GO:0048711)2.77911502
146negative regulation of fatty acid transport (GO:2000192)2.77329662
147hemidesmosome assembly (GO:0031581)2.76973937
148cortical actin cytoskeleton organization (GO:0030866)2.76928587
149hypotonic response (GO:0006971)2.76619757
150cell-substrate adherens junction assembly (GO:0007045)2.76569993
151focal adhesion assembly (GO:0048041)2.76569993
152cholesterol homeostasis (GO:0042632)2.76193087
153positive regulation of extracellular matrix organization (GO:1903055)2.75887490
154cellular modified amino acid catabolic process (GO:0042219)2.75877497
155bundle of His cell to Purkinje myocyte communication (GO:0086069)2.75614007
156sterol homeostasis (GO:0055092)2.74592831
157plasma lipoprotein particle organization (GO:0071827)2.74210236
158multicellular organismal metabolic process (GO:0044236)2.73910499
159adherens junction assembly (GO:0034333)2.73770251
160membrane protein ectodomain proteolysis (GO:0006509)2.73313847
161regulation of complement activation (GO:0030449)2.72549344
162substrate adhesion-dependent cell spreading (GO:0034446)2.71743202
163vesicle coating (GO:0006901)2.71095524
164metanephric mesenchyme development (GO:0072075)2.70699501
165blood vessel endothelial cell migration (GO:0043534)2.70676935
166negative regulation of stem cell proliferation (GO:2000647)2.70242850
167bone trabecula formation (GO:0060346)2.70136848
168positive regulation of lipid catabolic process (GO:0050996)2.69976259
169vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.69599240
170glutamate metabolic process (GO:0006536)2.68702261
171alpha-amino acid catabolic process (GO:1901606)2.68373900
172positive regulation of epithelial cell migration (GO:0010634)2.68373374
173aldehyde catabolic process (GO:0046185)2.67117273
174intestinal cholesterol absorption (GO:0030299)2.66750190
175response to nitrosative stress (GO:0051409)2.66228290
176cellular ketone body metabolic process (GO:0046950)2.65011290
177extracellular matrix organization (GO:0030198)2.64878155
178positive regulation of endothelial cell migration (GO:0010595)2.64615428
179positive regulation of axon extension (GO:0045773)2.63786752
180extracellular structure organization (GO:0043062)2.63762030
181regulation of smooth muscle cell migration (GO:0014910)2.63670885
182bile acid and bile salt transport (GO:0015721)2.62966476
183multicellular organismal catabolic process (GO:0044243)2.62405161
184protein-lipid complex subunit organization (GO:0071825)2.61917624
185sterol transport (GO:0015918)2.61620782
186cholesterol transport (GO:0030301)2.61620782
187epithelial cell-cell adhesion (GO:0090136)2.61597705
188SMAD protein complex assembly (GO:0007183)2.60425483
189negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.59689813
190negative regulation of nitric-oxide synthase activity (GO:0051001)2.59087790
191short-chain fatty acid metabolic process (GO:0046459)2.58299176
192regulation of bile acid biosynthetic process (GO:0070857)2.57587801
193ethanol metabolic process (GO:0006067)2.56828963
194intestinal absorption (GO:0050892)2.56598483
195positive regulation of fatty acid biosynthetic process (GO:0045723)2.54079907
196positive regulation of steroid metabolic process (GO:0045940)2.54047202

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.58901708
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.47316683
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.40136049
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.87312472
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.80741304
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.71215198
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.30139301
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.04587071
9RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.93892690
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.89685746
11BRD4_25478319_ChIP-Seq_HGPS_Human2.78319869
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.64890730
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.53672160
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.40823392
15* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.29381486
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.22899498
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.11068560
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.08474656
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05975339
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03918734
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.02908656
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.98085456
23P300_27058665_Chip-Seq_ZR-75-30cells_Human1.92084252
24* UBF1/2_26484160_Chip-Seq_HMECs_Human1.88019551
25ZNF263_19887448_ChIP-Seq_K562_Human1.86710395
26AR_21909140_ChIP-Seq_LNCAP_Human1.85566436
27ATF3_27146783_Chip-Seq_COLON_Human1.84669563
28TP53_22127205_ChIP-Seq_IMR90_Human1.81436849
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.78169764
30CLOCK_20551151_ChIP-Seq_293T_Human1.76328834
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75575081
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73693500
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.72152143
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.72047371
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70715969
36* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.66253370
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64517734
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.62266476
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.60584264
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.60412370
41RUNX_20019798_ChIP-Seq_JUKART_Human1.59602429
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.58416626
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57586178
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.57411828
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.56433804
46* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55460746
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52796013
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52586066
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47233343
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47211220
51HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.46724400
52SOX2_27498859_Chip-Seq_STOMACH_Mouse1.43964549
53* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43829997
54* SOX2_20726797_ChIP-Seq_SW620_Human1.43616656
55FOXA2_19822575_ChIP-Seq_HepG2_Human1.41870775
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39805237
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37891082
58RACK7_27058665_Chip-Seq_MCF-7_Human1.37331272
59* GATA4_25053715_ChIP-Seq_YYC3_Human1.37019788
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36731000
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36140304
62* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.35445894
63TP53_18474530_ChIP-ChIP_U2OS_Human1.34227737
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33453388
65EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.32334146
66SMC1_22415368_ChIP-Seq_MEFs_Mouse1.32306798
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32017595
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.30444353
69* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29789804
70MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.28980266
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28823926
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27056006
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26393080
74TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.26152229
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.25588066
76* CJUN_26792858_Chip-Seq_BT549_Human1.24277099
77NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24145983
78TP53_23651856_ChIP-Seq_MEFs_Mouse1.23441572
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21491248
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20312320
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19539304
82EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18666609
83TP53_16413492_ChIP-PET_HCT116_Human1.17275975
84* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13871385
85* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13871385
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10765324
87* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10738971
88* EGR1_19032775_ChIP-ChIP_M12_Human1.08112619
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08100806
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07556163
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06996093
92GATA1_22025678_ChIP-Seq_K562_Human1.06790956
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06709434
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06709434
95BP1_19119308_ChIP-ChIP_Hs578T_Human1.06404947
96* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06067949
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05128839
98AR_21572438_ChIP-Seq_LNCaP_Human1.04823928
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04584060
100SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01759946
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01680735
102P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01368187
103* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99098565
104LXR_22292898_ChIP-Seq_THP-1_Human0.98898955
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98775963
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98571716
107AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98006030
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98004610
109EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97896290
110GATA6_25053715_ChIP-Seq_YYC3_Human0.97884863
111VDR_24787735_ChIP-Seq_THP-1_Human0.97349614
112* HNF4A_19822575_ChIP-Seq_HepG2_Human0.93254919
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93227301
114GATA3_24758297_ChIP-Seq_MCF-7_Human0.93015257
115FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92867640
116GATA2_19941826_ChIP-Seq_K562_Human0.92793932
117SA1_22415368_ChIP-Seq_MEFs_Mouse0.92190139
118STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91049722
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90930523
120SOX17_20123909_ChIP-Seq_XEN_Mouse0.90676034
121ELK1_22589737_ChIP-Seq_MCF10A_Human0.89135997
122KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89090488
123SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88410666
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88301700
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87755651
126JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85998261
127FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85562725
128NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85474772
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85303962
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84888086
131* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84421020
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84304150
133SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83878379
134STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83521876
135ZFX_18555785_ChIP-Seq_MESCs_Mouse0.83273627
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82770972
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.82572358
138* TP63_23658742_ChIP-Seq_EP156T_Human0.82164914
139ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80594442
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80440196
141* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.80325667
142IRF8_27001747_Chip-Seq_BMDM_Mouse0.79418082
143* TBX20_22080862_ChIP-Seq_HEART_Mouse0.79240939
144* TBX20_22328084_ChIP-Seq_HEART_Mouse0.79240939
145RUNX1_27514584_Chip-Seq_MCF-7_Human0.78639701
146BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78049318
147EP300_21415370_ChIP-Seq_HL-1_Mouse0.77878096
148KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.77270480
149BCAT_22108803_ChIP-Seq_LS180_Human0.77071321
150AHR_22903824_ChIP-Seq_MCF-7_Human0.76383712
151TCF4_18268006_ChIP-ChIP_LS174T_Human0.76007908

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.01932841
2MP0002139_abnormal_hepatobiliary_system5.26887254
3MP0005085_abnormal_gallbladder_physiolo3.65050800
4MP0008875_abnormal_xenobiotic_pharmacok3.51333545
5MP0005365_abnormal_bile_salt3.45470466
6MP0003011_delayed_dark_adaptation3.24406340
7MP0005257_abnormal_intraocular_pressure3.16591336
8MP0005623_abnormal_meninges_morphology3.04950370
9MP0002877_abnormal_melanocyte_morpholog2.95456886
10MP0003279_aneurysm2.91439776
11MP0003252_abnormal_bile_duct2.79061949
12MP0004019_abnormal_vitamin_homeostasis2.70478383
13MP0003806_abnormal_nucleotide_metabolis2.56859823
14MP0002138_abnormal_hepatobiliary_system2.55669772
15MP0010329_abnormal_lipoprotein_level2.27694533
16MP0009840_abnormal_foam_cell2.27516140
17MP0003091_abnormal_cell_migration2.27425339
18MP0003300_gastrointestinal_ulcer2.26293936
19MP0001542_abnormal_bone_strength2.21896321
20MP0005332_abnormal_amino_acid2.21304783
21MP0002933_joint_inflammation2.15779193
22MP0001666_abnormal_nutrient_absorption2.13185514
23MP0010352_gastrointestinal_tract_polyps2.12227261
24MP0003195_calcinosis2.10328586
25MP0010234_abnormal_vibrissa_follicle2.07651899
26MP0006054_spinal_hemorrhage2.06579447
27MP0009780_abnormal_chondrocyte_physiolo2.03708441
28MP0000751_myopathy1.94753694
29MP0003436_decreased_susceptibility_to1.84201428
30MP0010030_abnormal_orbit_morphology1.76407472
31MP0001299_abnormal_eye_distance/1.72392221
32MP0003191_abnormal_cellular_cholesterol1.71735039
33MP0009053_abnormal_anal_canal1.70829211
34MP0000767_abnormal_smooth_muscle1.69609265
35MP0003941_abnormal_skin_development1.62430462
36MP0005551_abnormal_eye_electrophysiolog1.61202157
37MP0009643_abnormal_urine_homeostasis1.58389339
38MP0000733_abnormal_muscle_development1.52917745
39MP0000013_abnormal_adipose_tissue1.52178555
40MP0000609_abnormal_liver_physiology1.48098208
41MP0000762_abnormal_tongue_morphology1.45933579
42MP0001849_ear_inflammation1.43662223
43MP0003705_abnormal_hypodermis_morpholog1.43491974
44MP0000534_abnormal_ureter_morphology1.41322512
45MP0009697_abnormal_copulation1.40868643
46MP0001879_abnormal_lymphatic_vessel1.32708744
47MP0005275_abnormal_skin_tensile1.31821071
48* MP0002136_abnormal_kidney_physiology1.31263809
49MP0001764_abnormal_homeostasis1.30992016
50MP0001533_abnormal_skeleton_physiology1.29093698
51MP0003566_abnormal_cell_adhesion1.28737564
52MP0005023_abnormal_wound_healing1.28590487
53MP0000749_muscle_degeneration1.28437104
54MP0005083_abnormal_biliary_tract1.28025419
55MP0004858_abnormal_nervous_system1.27099053
56MP0005508_abnormal_skeleton_morphology1.26687821
57MP0002118_abnormal_lipid_homeostasis1.25852638
58MP0001873_stomach_inflammation1.24030097
59MP0002295_abnormal_pulmonary_circulatio1.22667699
60MP0004947_skin_inflammation1.22560708
61MP0002254_reproductive_system_inflammat1.21714110
62MP0002282_abnormal_trachea_morphology1.20734305
63MP0005164_abnormal_response_to1.20405216
64MP0005451_abnormal_body_composition1.20132257
65MP0009384_cardiac_valve_regurgitation1.19790613
66MP0005165_increased_susceptibility_to1.19520387
67MP0000858_altered_metastatic_potential1.18889805
68MP0001756_abnormal_urination1.18639567
69MP0009764_decreased_sensitivity_to1.18076714
70MP0004782_abnormal_surfactant_physiolog1.16277386
71MP0002168_other_aberrant_phenotype1.14625283
72MP0005636_abnormal_mineral_homeostasis1.13583374
73MP0005197_abnormal_uvea_morphology1.13063002
74MP0005595_abnormal_vascular_smooth1.12428219
75MP0002098_abnormal_vibrissa_morphology1.12140358
76* MP0005319_abnormal_enzyme/_coenzyme1.10886876
77MP0000537_abnormal_urethra_morphology1.09642169
78MP0001348_abnormal_lacrimal_gland1.06971606
79MP0005503_abnormal_tendon_morphology1.06793065
80MP0001765_abnormal_ion_homeostasis1.04242689
81MP0003950_abnormal_plasma_membrane1.04183102
82MP0002796_impaired_skin_barrier1.02814613
83MP0003724_increased_susceptibility_to1.00980298
84MP0004272_abnormal_basement_membrane1.00899565
85MP0005584_abnormal_enzyme/coenzyme_acti1.00307654
86MP0000003_abnormal_adipose_tissue0.98870151
87MP0003385_abnormal_body_wall0.98364664
88MP0009250_abnormal_appendicular_skeleto0.97466950
89MP0000604_amyloidosis0.97367679
90MP0000750_abnormal_muscle_regeneration0.97094427
91MP0001663_abnormal_digestive_system0.96785908
92MP0002060_abnormal_skin_morphology0.96031440
93MP0010155_abnormal_intestine_physiology0.93881765
94MP0001915_intracranial_hemorrhage0.93276980
95MP0004510_myositis0.93212769
96MP0000759_abnormal_skeletal_muscle0.93111765
97MP0000467_abnormal_esophagus_morphology0.93002367
98MP0008004_abnormal_stomach_pH0.92891601
99MP0003448_altered_tumor_morphology0.92679024
100MP0000465_gastrointestinal_hemorrhage0.92542782
101MP0001790_abnormal_immune_system0.92325827
102MP0005387_immune_system_phenotype0.92325827
103MP0003868_abnormal_feces_composition0.92275583
104MP0003045_fibrosis0.90614100
105MP0000428_abnormal_craniofacial_morphol0.90026868
106MP0001216_abnormal_epidermal_layer0.89627978
107MP0004233_abnormal_muscle_weight0.89295916
108MP0005253_abnormal_eye_physiology0.88713899
109MP0000163_abnormal_cartilage_morphology0.88534867
110MP0002998_abnormal_bone_remodeling0.88026042
111MP0005408_hypopigmentation0.87759901
112MP0003453_abnormal_keratinocyte_physiol0.87025032
113MP0001845_abnormal_inflammatory_respons0.84779285
114* MP0008469_abnormal_protein_level0.84677642
115MP0010368_abnormal_lymphatic_system0.83182039
116MP0002177_abnormal_outer_ear0.82692834
117MP0002089_abnormal_postnatal_growth/wei0.82548335
118MP0002166_altered_tumor_susceptibility0.81834740
119MP0002115_abnormal_skeleton_extremities0.81207145
120MP0002896_abnormal_bone_mineralization0.81107875
121MP0003763_abnormal_thymus_physiology0.80618837
122MP0005058_abnormal_lysosome_morphology0.80447902
123MP0009785_altered_susceptibility_to0.79563487
124MP0001958_emphysema0.79465800
125MP0001614_abnormal_blood_vessel0.79225434
126MP0005381_digestive/alimentary_phenotyp0.78942118
127MP0003942_abnormal_urinary_system0.78475514
128MP0008438_abnormal_cutaneous_collagen0.78121469
129MP0005621_abnormal_cell_physiology0.77907466
130MP0009763_increased_sensitivity_to0.75230450
131MP0005501_abnormal_skin_physiology0.74911453
132MP0003795_abnormal_bone_structure0.74731809
133MP0002332_abnormal_exercise_endurance0.74310580
134MP0005409_darkened_coat_color0.73967954
135MP0005390_skeleton_phenotype0.73324505
136MP0003828_pulmonary_edema0.73296812
137MP0002132_abnormal_respiratory_system0.72942729
138MP0009765_abnormal_xenobiotic_induced0.72899092
139MP0004134_abnormal_chest_morphology0.72427900
140MP0005193_abnormal_anterior_eye0.71824154
141MP0002419_abnormal_innate_immunity0.70978828
142MP0002113_abnormal_skeleton_development0.70427089
143MP0010771_integument_phenotype0.70342208
144MP0003186_abnormal_redox_activity0.69259134
145MP0005025_abnormal_response_to0.68077664
146MP0000432_abnormal_head_morphology0.67145331
147MP0000685_abnormal_immune_system0.67142274
148MP0000427_abnormal_hair_cycle0.66977391
149MP0005166_decreased_susceptibility_to0.66826112
150MP0005248_abnormal_Harderian_gland0.66564614
151MP0002925_abnormal_cardiovascular_devel0.65970261
152* MP0002128_abnormal_blood_circulation0.65893510
153MP0003303_peritoneal_inflammation0.65504519
154MP0006082_CNS_inflammation0.65504017
155MP0010678_abnormal_skin_adnexa0.64863856
156MP0000627_abnormal_mammary_gland0.64002634
157MP0000598_abnormal_liver_morphology0.63922954
158MP0005167_abnormal_blood-brain_barrier0.62735497
159MP0003115_abnormal_respiratory_system0.62529723
160MP0001243_abnormal_dermal_layer0.61983109
161MP0003755_abnormal_palate_morphology0.61483521
162MP0008260_abnormal_autophagy0.61061950
163MP0002932_abnormal_joint_morphology0.60647518
164MP0005330_cardiomyopathy0.60268626
165MP0010386_abnormal_urinary_bladder0.58715496
166MP0003329_amyloid_beta_deposits0.57708748
167MP0006138_congestive_heart_failure0.57340827
168MP0004087_abnormal_muscle_fiber0.57268411
169MP0005076_abnormal_cell_differentiation0.56950065

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.25877957
2Protrusio acetabuli (HP:0003179)6.47035109
3Vitreoretinal degeneration (HP:0000655)5.72078981
4Epiphyseal dysplasia (HP:0002656)5.02653258
5Atrophic scars (HP:0001075)4.76614590
6Abnormal tarsal ossification (HP:0008369)4.59052044
7Ankle contracture (HP:0006466)4.43467792
8Aortic dissection (HP:0002647)4.39865871
9Vascular tortuosity (HP:0004948)4.23667121
10Arterial tortuosity (HP:0005116)4.12261480
11Metaphyseal cupping (HP:0003021)4.08531477
12Hyperactive renin-angiotensin system (HP:0000841)3.95867029
13Aortic aneurysm (HP:0004942)3.92153945
14Cervical subluxation (HP:0003308)3.89225661
15Vertebral compression fractures (HP:0002953)3.88500291
16Follicular hyperkeratosis (HP:0007502)3.88423420
17Deep venous thrombosis (HP:0002625)3.87328959
18Pigmentary retinal degeneration (HP:0001146)3.85897290
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.84492331
20Spinal rigidity (HP:0003306)3.83507418
21Flat acetabular roof (HP:0003180)3.80197612
22Hypokalemic alkalosis (HP:0001949)3.70043655
23Irregular epiphyses (HP:0010582)3.65546505
24Cupped ribs (HP:0000887)3.65512732
25Short nail (HP:0001799)3.62594445
26Abnormal foot bone ossification (HP:0010675)3.60182305
27Osteolytic defects of the hand bones (HP:0009699)3.51978393
28Osteolytic defects of the phalanges of the hand (HP:0009771)3.51978393
29Fragile skin (HP:0001030)3.51729179
30Wormian bones (HP:0002645)3.43436369
31Chorioretinal atrophy (HP:0000533)3.42099382
32Intrahepatic cholestasis (HP:0001406)3.36482489
33Xanthomatosis (HP:0000991)3.35156031
34Abnormality of monocarboxylic acid metabolism (HP:0010996)3.24479872
35Bladder diverticulum (HP:0000015)3.22038343
36Congenital stationary night blindness (HP:0007642)3.16418490
37Type 1 muscle fiber predominance (HP:0003803)3.13975161
38Delayed epiphyseal ossification (HP:0002663)3.11631442
39Abnormality of chloride homeostasis (HP:0011422)3.07068494
40Abnormality of dentin (HP:0010299)3.01765499
41Hypoplastic ischia (HP:0003175)3.00984211
42Conjugated hyperbilirubinemia (HP:0002908)2.98192639
43Shallow orbits (HP:0000586)2.97348980
44Soft skin (HP:0000977)2.96463807
45Hypobetalipoproteinemia (HP:0003563)2.95444306
46Increased connective tissue (HP:0009025)2.92932023
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.89298167
48Abnormality of proline metabolism (HP:0010907)2.86636194
49Hydroxyprolinuria (HP:0003080)2.86636194
50Mildly elevated creatine phosphokinase (HP:0008180)2.85860973
51Spondylolisthesis (HP:0003302)2.85679897
52Abnormality of the ischium (HP:0003174)2.84557634
53Achilles tendon contracture (HP:0001771)2.83366804
54Alkalosis (HP:0001948)2.83349688
55Slender build (HP:0001533)2.82869682
56Reduced subcutaneous adipose tissue (HP:0003758)2.77670391
57Dilatation of the ascending aorta (HP:0005111)2.75941716
58Elbow flexion contracture (HP:0002987)2.75208788
59Blue sclerae (HP:0000592)2.69333256
60Genu varum (HP:0002970)2.68627926
61Small epiphyses (HP:0010585)2.67752714
62Distal lower limb amyotrophy (HP:0008944)2.66647668
63Genu recurvatum (HP:0002816)2.65618400
64Prolonged partial thromboplastin time (HP:0003645)2.63806125
65Flat capital femoral epiphysis (HP:0003370)2.60617491
66Protuberant abdomen (HP:0001538)2.59453604
67* Vascular calcification (HP:0004934)2.59203947
68Natal tooth (HP:0000695)2.56893244
69Distal upper limb amyotrophy (HP:0007149)2.56487178
70Upper limb amyotrophy (HP:0009129)2.56487178
71Bony spicule pigmentary retinopathy (HP:0007737)2.56103204
72Abnormality of carpal bone ossification (HP:0006257)2.55150385
73Metaphyseal dysplasia (HP:0100255)2.54563346
74Cone-rod dystrophy (HP:0000548)2.54543304
75Mitral stenosis (HP:0001718)2.54425255
76Abnormality of the Achilles tendon (HP:0005109)2.54022156
77Esophageal varix (HP:0002040)2.53808719
78Ileus (HP:0002595)2.53655627
79Entropion (HP:0000621)2.49849396
80Mitral regurgitation (HP:0001653)2.43018483
81Arthropathy (HP:0003040)2.42696535
82Broad metatarsal (HP:0001783)2.42467825
83Right ventricular cardiomyopathy (HP:0011663)2.40338040
84Abnormality of sulfur amino acid metabolism (HP:0004339)2.40184274
85Hyperaldosteronism (HP:0000859)2.37769728
86Abnormality of the acetabulum (HP:0003170)2.37120514
87Abnormality of aspartate family amino acid metabolism (HP:0010899)2.36779124
88Hyperlipoproteinemia (HP:0010980)2.36647612
89Abnormality of the vertebral endplates (HP:0005106)2.36541765
90Joint hemorrhage (HP:0005261)2.36350449
91Abnormality of the common coagulation pathway (HP:0010990)2.36178355
92Enlarged epiphyses (HP:0010580)2.35992513
93Generalized amyotrophy (HP:0003700)2.35417198
94Cerebral aneurysm (HP:0004944)2.33849465
95Joint laxity (HP:0001388)2.33562019
96Spinal cord lesions (HP:0100561)2.32291777
97Syringomyelia (HP:0003396)2.32291777
98Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.31939170
99Hypolipoproteinemia (HP:0010981)2.31279253
100Metaphyseal irregularity (HP:0003025)2.30407288
101* Cardiovascular calcification (HP:0011915)2.30354765
102Mitral valve prolapse (HP:0001634)2.29537736
103Renal salt wasting (HP:0000127)2.28650783
104Abnormal vertebral ossification (HP:0100569)2.28518977
105Increased variability in muscle fiber diameter (HP:0003557)2.28112659
106Osteoarthritis (HP:0002758)2.27940746
107Abnormality of purine metabolism (HP:0004352)2.27304384
108Glucose intolerance (HP:0000833)2.24136121
109Aortic regurgitation (HP:0001659)2.23524547
110Malnutrition (HP:0004395)2.22800781
111Hyperglycinuria (HP:0003108)2.21476451
112Biconcave vertebral bodies (HP:0004586)2.21345079
113Difficulty climbing stairs (HP:0003551)2.20554929
114Broad face (HP:0000283)2.18569354
115Abnormality of the distal phalanges of the toes (HP:0010182)2.18319533
116Metabolic alkalosis (HP:0200114)2.18205476
117Lower limb amyotrophy (HP:0007210)2.15379127
118Abnormal delivery (HP:0001787)2.14667429
119Peritonitis (HP:0002586)2.14541170
120Spontaneous hematomas (HP:0007420)2.13570587
121Overgrowth (HP:0001548)2.12285175
122Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11162366
123Flattened epiphyses (HP:0003071)2.10884735
124Hand muscle atrophy (HP:0009130)2.09951674
125Hyperextensible skin (HP:0000974)2.08995729
126Hyperammonemia (HP:0001987)2.08954616
127Joint stiffness (HP:0001387)2.08556922
128Neonatal short-limb short stature (HP:0008921)2.08469182
129Irregular vertebral endplates (HP:0003301)2.08232911
130Interstitial pulmonary disease (HP:0006530)2.07557817
131Abnormality of skeletal muscle fiber size (HP:0012084)2.07542661
132Hypoalphalipoproteinemia (HP:0003233)2.07522226
133Abnormal ossification of hand bones (HP:0005921)2.07213044
134Ulnar bowing (HP:0003031)2.07033929
135Distal lower limb muscle weakness (HP:0009053)2.06438598
136Abolished electroretinogram (ERG) (HP:0000550)2.05990757
137Pustule (HP:0200039)2.05556718
138Aneurysm (HP:0002617)2.04513686
139Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.04075992
140Abnormality of femoral epiphyses (HP:0006499)2.04075992
141Abnormal hand bone ossification (HP:0010660)2.03083382
142Barrel-shaped chest (HP:0001552)2.02555672
143Milia (HP:0001056)2.02202821
144Hyperacusis (HP:0010780)2.00297207
145Abnormality of nucleobase metabolism (HP:0010932)1.98902401
146Bowel diverticulosis (HP:0005222)1.98526905
147Coxa vara (HP:0002812)1.98239037
148Limb-girdle muscle weakness (HP:0003325)1.98038815
149Central scotoma (HP:0000603)1.97254927
150Epidermoid cyst (HP:0200040)1.96013573
151Wrist flexion contracture (HP:0001239)1.95235722
152Onycholysis (HP:0001806)1.95180633
153Disproportionate tall stature (HP:0001519)1.95046040
154Glomerulonephritis (HP:0000099)1.94259231
155Abnormality of oral frenula (HP:0000190)1.94222919
156Fat malabsorption (HP:0002630)1.93411656
157Platyspondyly (HP:0000926)1.93400448
158Abnormal cartilage morphology (HP:0002763)1.90387722
159Limb-girdle muscle atrophy (HP:0003797)1.89950194
160Myocardial infarction (HP:0001658)1.89091928
161Exostoses (HP:0100777)1.88825460
162Abnormal rod and cone electroretinograms (HP:0008323)1.88249111
163Abnormality of the epiphysis of the femoral head (HP:0010574)1.87459538
164Spinal cord compression (HP:0002176)1.87257403
165Gout (HP:0001997)1.86658734
166Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85617982
167Aortic valve stenosis (HP:0001650)1.84876355
168Nephritis (HP:0000123)1.83599932
169Fragile nails (HP:0001808)1.83313063
170Insomnia (HP:0100785)1.83073563
171Abnormality of skull ossification (HP:0002703)1.82241850
172Short femoral neck (HP:0100864)1.82224405
173Protruding ear (HP:0000411)1.82094501
174Delayed cranial suture closure (HP:0000270)1.81553720
175Dyschromatopsia (HP:0007641)1.80918076
176Long toe (HP:0010511)1.80794176
177Hypoventilation (HP:0002791)1.80656131
178Abnormality of glycine metabolism (HP:0010895)1.80533416
179Abnormality of serine family amino acid metabolism (HP:0010894)1.80533416
180Abnormality of macular pigmentation (HP:0008002)1.79935458
181Beaking of vertebral bodies (HP:0004568)1.77504340
182Absent frontal sinuses (HP:0002688)1.77004795
183Ankyloglossia (HP:0010296)1.76949958
184Ectopia lentis (HP:0001083)1.76091772
185Metabolic acidosis (HP:0001942)1.74653280
186Round ear (HP:0100830)1.74532122
187Back pain (HP:0003418)1.74488590
188Abnormality of the umbilical cord (HP:0010881)1.74099976
189Delayed closure of the anterior fontanelle (HP:0001476)1.72778039
190Thin skin (HP:0000963)1.70889620
191Short clavicles (HP:0000894)1.69070175
192Decreased skull ossification (HP:0004331)1.68202889
193Ovoid vertebral bodies (HP:0003300)1.66387286
194Upper limb muscle weakness (HP:0003484)1.65921299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK23.73481362
2FGFR43.33223842
3MAP3K33.17892979
4LIMK13.05824998
5TESK12.95542569
6MST42.74377852
7TXK2.66830825
8MOS2.53288088
9MST1R2.51589948
10NTRK12.48433075
11FRK2.48344500
12ERBB42.27182628
13LATS12.25326703
14IRAK32.24482839
15STK38L2.11068177
16TYK22.01653078
17WNK42.00034157
18LATS21.98622256
19STK101.94603829
20SIK11.94231869
21GRK11.89618078
22PRKG21.89394759
23EPHA21.88291518
24MAP4K11.87567869
25EPHB11.85186208
26FGFR31.78193587
27NME21.76921203
28ERN11.75814322
29PAK21.69657013
30STK241.68477603
31JAK11.65973072
32SCYL21.60753261
33FLT31.52992053
34ICK1.52431613
35PTK61.51638901
36TGFBR21.50792482
37ARAF1.49450729
38MAP3K141.48593088
39TESK21.47239603
40IKBKE1.45568290
41DDR21.37707516
42ITK1.37446466
43STK381.36367182
44CSK1.29470328
45NUAK11.26809090
46LRRK21.24055250
47TBK11.20419055
48PIM21.16177492
49ABL21.13159130
50BCKDK1.12330532
51FER1.11285515
52EPHB21.11149908
53JAK31.10646343
54ROCK21.06483557
55PAK61.05056958
56ILK1.04358625
57STK391.04011299
58PBK1.03931870
59MYLK1.02511292
60MET1.01927605
61TAOK30.99748651
62PTK20.97999463
63TAOK10.96545748
64OXSR10.96060577
65GRK60.95324555
66PKN20.94988023
67MAP2K30.94449338
68PRKD20.94057073
69MAP3K120.93866012
70TAOK20.92544847
71CDK80.91864279
72TTN0.89815484
73FGFR20.89737672
74STK30.88065951
75PDK20.87946002
76PTK2B0.87890493
77ZAP700.87218644
78BUB10.83453687
79EPHA30.82821851
80SMG10.82453530
81KDR0.81579020
82MAP3K70.80298539
83NLK0.77428161
84TIE10.76853850
85MAPK70.75296694
86PRKCQ0.74559064
87TRIB30.73879486
88MAP3K20.73218842
89NEK10.73143543
90BMX0.72323205
91PRKCH0.71558954
92SGK30.70869445
93CHUK0.70596027
94TRPM70.70398900
95MAP3K80.69449370
96PIK3CA0.68269465
97PAK10.68180223
98MAP3K60.66124876
99MARK30.64699922
100MTOR0.64679707
101NEK20.61968173
102PRPF4B0.61536242
103FGFR10.61528987
104TEC0.61170160
105MELK0.60449717
106ROCK10.59576116
107MAPK120.58143072
108BRAF0.57954772
109LCK0.57865444
110JAK20.57731480
111GSK3A0.57507569
112PDGFRB0.57326877
113RIPK10.56475069
114DMPK0.54339766
115BRSK10.52572223
116NEK90.52204333
117SGK2230.51384467
118SGK4940.51384467
119CDC42BPA0.51161387
120MAP3K110.50689012
121IGF1R0.49880541
122ADRBK10.49796003
123MAPK110.48875697
124EIF2AK10.45393805
125CDK60.45169774
126PAK40.44778253
127WNK10.44642250
128INSRR0.44521162
129HCK0.44047539
130PDGFRA0.44002882
131IKBKB0.42510335
132BLK0.42415125
133MAPK40.42318346
134KSR10.42228801
135MAPKAPK20.42208114
136SGK20.41650895
137CDK120.40544589
138PRKAA20.39003274
139RPS6KA20.38705359
140KIT0.38624546
141CDK180.37981973
142DAPK30.37953904
143SIK30.37811388
144EGFR0.37791519
145CDK150.37657536
146WNK30.37488539
147CDK140.37120489
148ERBB30.36842304
149IRAK20.36509909
150FYN0.35656684
151INSR0.35366230
152NME10.35361387
153CLK10.34936206
154GRK70.34748217
155CAMK2G0.34672657
156AURKA0.33851718
157CDK11A0.33366915
158KSR20.32497980
159PIK3CG0.30698573
160GRK50.29814472
161CDK90.28411320
162MAP3K130.27921579
163CDK70.27612265
164CAMK2D0.25812868
165AURKB0.24773774
166RAF10.24725575

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35737785
2Phototransduction_Homo sapiens_hsa047442.89951794
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.76426840
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.67987587
5Nitrogen metabolism_Homo sapiens_hsa009102.42978662
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.35572074
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.35362512
8Fatty acid degradation_Homo sapiens_hsa000712.34876702
9Arginine biosynthesis_Homo sapiens_hsa002202.32651355
10Complement and coagulation cascades_Homo sapiens_hsa046102.20372147
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20328970
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.15883319
13Tryptophan metabolism_Homo sapiens_hsa003802.14032689
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.12162769
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12070208
16Bladder cancer_Homo sapiens_hsa052192.11553946
17Glycosaminoglycan degradation_Homo sapiens_hsa005312.10610754
18Retinol metabolism_Homo sapiens_hsa008301.99823950
19Chemical carcinogenesis_Homo sapiens_hsa052041.97855010
20Staphylococcus aureus infection_Homo sapiens_hsa051501.93536698
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.91538184
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91299015
23Regulation of actin cytoskeleton_Homo sapiens_hsa048101.87809368
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82073819
25Vitamin digestion and absorption_Homo sapiens_hsa049771.77609644
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75174431
27Caffeine metabolism_Homo sapiens_hsa002321.74677483
28Histidine metabolism_Homo sapiens_hsa003401.73006893
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.71356715
30Bile secretion_Homo sapiens_hsa049761.68976735
31Peroxisome_Homo sapiens_hsa041461.68672097
32PPAR signaling pathway_Homo sapiens_hsa033201.68489087
33Sulfur metabolism_Homo sapiens_hsa009201.67825806
34Dilated cardiomyopathy_Homo sapiens_hsa054141.67654544
35Butanoate metabolism_Homo sapiens_hsa006501.64391379
36Shigellosis_Homo sapiens_hsa051311.62851549
37Chronic myeloid leukemia_Homo sapiens_hsa052201.61404586
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.60713925
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.58062707
40Fatty acid metabolism_Homo sapiens_hsa012121.56493607
41beta-Alanine metabolism_Homo sapiens_hsa004101.56004159
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.54093177
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50678751
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47361893
45Starch and sucrose metabolism_Homo sapiens_hsa005001.44923099
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.44581615
47MicroRNAs in cancer_Homo sapiens_hsa052061.43546686
48Phenylalanine metabolism_Homo sapiens_hsa003601.43115986
49N-Glycan biosynthesis_Homo sapiens_hsa005101.42482263
50Propanoate metabolism_Homo sapiens_hsa006401.40636648
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.39737576
52ABC transporters_Homo sapiens_hsa020101.39368777
53Thyroid cancer_Homo sapiens_hsa052161.36938373
54Fat digestion and absorption_Homo sapiens_hsa049751.36381779
55Pancreatic cancer_Homo sapiens_hsa052121.35001584
56ECM-receptor interaction_Homo sapiens_hsa045121.34412406
57Prion diseases_Homo sapiens_hsa050201.34207341
58Hippo signaling pathway_Homo sapiens_hsa043901.33779790
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27575656
60Melanoma_Homo sapiens_hsa052181.26518644
61Mineral absorption_Homo sapiens_hsa049781.24125837
62Cyanoamino acid metabolism_Homo sapiens_hsa004601.21722670
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20651615
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18621240
65Drug metabolism - other enzymes_Homo sapiens_hsa009831.17715326
66Vibrio cholerae infection_Homo sapiens_hsa051101.16911914
67Protein digestion and absorption_Homo sapiens_hsa049741.16618582
68TGF-beta signaling pathway_Homo sapiens_hsa043501.15150903
69Selenocompound metabolism_Homo sapiens_hsa004501.13918071
70p53 signaling pathway_Homo sapiens_hsa041151.12420991
71Pathways in cancer_Homo sapiens_hsa052001.07398738
72Glioma_Homo sapiens_hsa052141.07285734
73Pyruvate metabolism_Homo sapiens_hsa006201.05953419
74Endocytosis_Homo sapiens_hsa041441.05072704
75Tyrosine metabolism_Homo sapiens_hsa003501.03568897
76Lysine degradation_Homo sapiens_hsa003101.02197573
77Salmonella infection_Homo sapiens_hsa051321.00618452
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99930334
79Glycerolipid metabolism_Homo sapiens_hsa005610.99539498
80Fatty acid elongation_Homo sapiens_hsa000620.98316476
81Steroid biosynthesis_Homo sapiens_hsa001000.96957719
82Axon guidance_Homo sapiens_hsa043600.95861438
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95215548
84Renal cell carcinoma_Homo sapiens_hsa052110.94240075
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92266645
86Apoptosis_Homo sapiens_hsa042100.86257194
87Endometrial cancer_Homo sapiens_hsa052130.86032676
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85543830
89Arginine and proline metabolism_Homo sapiens_hsa003300.83114560
90Glutathione metabolism_Homo sapiens_hsa004800.83021316
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82706530
92Folate biosynthesis_Homo sapiens_hsa007900.82513008
93Prostate cancer_Homo sapiens_hsa052150.79838831
94Non-small cell lung cancer_Homo sapiens_hsa052230.79297181
95TNF signaling pathway_Homo sapiens_hsa046680.75831223
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75805976
97Gap junction_Homo sapiens_hsa045400.74033517
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72817715
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72004147
100ErbB signaling pathway_Homo sapiens_hsa040120.68894651
101Tight junction_Homo sapiens_hsa045300.68758569
102Rap1 signaling pathway_Homo sapiens_hsa040150.68703480
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68458478
104Lysosome_Homo sapiens_hsa041420.66407274
105Renin-angiotensin system_Homo sapiens_hsa046140.66157817
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.66043085
107Carbon metabolism_Homo sapiens_hsa012000.64719345
108Basal cell carcinoma_Homo sapiens_hsa052170.64093069
109VEGF signaling pathway_Homo sapiens_hsa043700.63840111
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62296690
111Hedgehog signaling pathway_Homo sapiens_hsa043400.59410507
112Primary immunodeficiency_Homo sapiens_hsa053400.58987364
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56943777
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.56285375
115Hepatitis B_Homo sapiens_hsa051610.54719472
116Pertussis_Homo sapiens_hsa051330.54032646
117Biosynthesis of amino acids_Homo sapiens_hsa012300.53408505
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52554963
119Melanogenesis_Homo sapiens_hsa049160.51457905
120Colorectal cancer_Homo sapiens_hsa052100.50855521
121Estrogen signaling pathway_Homo sapiens_hsa049150.49399778
122HTLV-I infection_Homo sapiens_hsa051660.48968045
123Phagosome_Homo sapiens_hsa041450.48621750
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.48153536
125Sphingolipid metabolism_Homo sapiens_hsa006000.47378799
126Focal adhesion_Homo sapiens_hsa045100.47166816
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46776358
128Fatty acid biosynthesis_Homo sapiens_hsa000610.46674507
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.46472475
130Wnt signaling pathway_Homo sapiens_hsa043100.45895379
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.44853747
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.44446967
133Ras signaling pathway_Homo sapiens_hsa040140.43665736
134Viral carcinogenesis_Homo sapiens_hsa052030.43426060
135Nucleotide excision repair_Homo sapiens_hsa034200.42987754
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42531185
137Other glycan degradation_Homo sapiens_hsa005110.39213042
138Toxoplasmosis_Homo sapiens_hsa051450.37655286
139GnRH signaling pathway_Homo sapiens_hsa049120.37538708
140HIF-1 signaling pathway_Homo sapiens_hsa040660.36947360
141* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35414421
142Insulin signaling pathway_Homo sapiens_hsa049100.35386910
143Acute myeloid leukemia_Homo sapiens_hsa052210.35331831
144T cell receptor signaling pathway_Homo sapiens_hsa046600.34923459
145Leishmaniasis_Homo sapiens_hsa051400.34901805
146Malaria_Homo sapiens_hsa051440.33939646
147Cell cycle_Homo sapiens_hsa041100.33875123
148Insulin resistance_Homo sapiens_hsa049310.33253847
149Hematopoietic cell lineage_Homo sapiens_hsa046400.32002238
150Platelet activation_Homo sapiens_hsa046110.31563896
151Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31405080
152Notch signaling pathway_Homo sapiens_hsa043300.31392142
153Adherens junction_Homo sapiens_hsa045200.31282829
154Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30393501
155Amoebiasis_Homo sapiens_hsa051460.29680362
156Pentose phosphate pathway_Homo sapiens_hsa000300.29422181
157Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29224627
158Adipocytokine signaling pathway_Homo sapiens_hsa049200.29148774
159Small cell lung cancer_Homo sapiens_hsa052220.27192918
160NF-kappa B signaling pathway_Homo sapiens_hsa040640.26381196
161Fructose and mannose metabolism_Homo sapiens_hsa000510.24388783
162Hepatitis C_Homo sapiens_hsa051600.24291182
163Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23791795
164Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23139031
165Thyroid hormone synthesis_Homo sapiens_hsa049180.19165093
166Proteoglycans in cancer_Homo sapiens_hsa052050.18852752
167Galactose metabolism_Homo sapiens_hsa000520.18667180
168Maturity onset diabetes of the young_Homo sapiens_hsa049500.18136611
169Jak-STAT signaling pathway_Homo sapiens_hsa046300.17474851
170Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16553089
171Viral myocarditis_Homo sapiens_hsa054160.16221857
172Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16218962
173Osteoclast differentiation_Homo sapiens_hsa043800.14162773

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