ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cornea development in camera-type eye (GO:0061303)	6.21873723
2	platelet dense granule organization (GO:0060155)	4.94261717
3	neural tube formation (GO:0001841)	4.82349802
4	nonmotile primary cilium assembly (GO:0035058)	4.68690411
5	fibroblast migration (GO:0010761)	4.64558874
6	response to pheromone (GO:0019236)	4.52525082
7	detection of light stimulus involved in visual perception (GO:0050908)	4.28675137
8	detection of light stimulus involved in sensory perception (GO:0050962)	4.28675137
9	pharyngeal system development (GO:0060037)	4.17108675
10	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	4.13993945
11	negative regulation of nitric-oxide synthase activity (GO:0051001)	4.10633987
12	cell migration in hindbrain (GO:0021535)	4.09575734
13	receptor recycling (GO:0001881)	4.07462016
14	myelin assembly (GO:0032288)	4.05566639
15	centrosome localization (GO:0051642)	3.99038068
16	behavioral response to nicotine (GO:0035095)	3.93181520
17	negative regulation of neurological system process (GO:0031645)	3.90079037
18	transepithelial transport (GO:0070633)	3.85236618
19	negative regulation of mast cell activation (GO:0033004)	3.84902065
20	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	3.71922722
21	positive regulation of amino acid transport (GO:0051957)	3.70651660
22	glial cell proliferation (GO:0014009)	3.66625682
23	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.62583949
24	mitochondrion transport along microtubule (GO:0047497)	3.62583949
25	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.58984187
26	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.58984187
27	peptidyl-histidine modification (GO:0018202)	3.53911578
28	L-fucose catabolic process (GO:0042355)	3.52404591
29	fucose catabolic process (GO:0019317)	3.52404591
30	L-fucose metabolic process (GO:0042354)	3.52404591
31	positive regulation of sodium ion transmembrane transport (GO:1902307)	3.51260879
32	establishment of mitochondrion localization (GO:0051654)	3.50734253
33	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.47196309
34	protein K11-linked deubiquitination (GO:0035871)	3.46335765
35	one-carbon compound transport (GO:0019755)	3.45661577
36	positive regulation of heat generation (GO:0031652)	3.39777809
37	acrosome assembly (GO:0001675)	3.31575262
38	photoreceptor cell maintenance (GO:0045494)	3.25575585
39	cytochrome complex assembly (GO:0017004)	3.22875983
40	sex differentiation (GO:0007548)	3.21107793
41	regulation of heat generation (GO:0031650)	3.15957336
42	regulation of hippo signaling (GO:0035330)	3.14621453
43	protein import into peroxisome matrix (GO:0016558)	3.12142145
44	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.08903195
45	indolalkylamine metabolic process (GO:0006586)	3.04967469
46	regulation of feeding behavior (GO:0060259)	2.97879041
47	embryonic epithelial tube formation (GO:0001838)	2.96549777
48	water-soluble vitamin biosynthetic process (GO:0042364)	2.95086186
49	somite development (GO:0061053)	2.94905778
50	intraciliary transport (GO:0042073)	2.93415996
51	estrogen biosynthetic process (GO:0006703)	2.92808136
52	tryptophan catabolic process (GO:0006569)	2.91579233
53	indole-containing compound catabolic process (GO:0042436)	2.91579233
54	indolalkylamine catabolic process (GO:0046218)	2.91579233
55	NLS-bearing protein import into nucleus (GO:0006607)	2.90499287
56	regulation of action potential (GO:0098900)	2.88085163
57	magnesium ion transport (GO:0015693)	2.86627716
58	neural crest cell development (GO:0014032)	2.81777379
59	protein targeting to peroxisome (GO:0006625)	2.78912616
60	establishment of protein localization to peroxisome (GO:0072663)	2.78912616
61	protein localization to peroxisome (GO:0072662)	2.78912616
62	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.78432493
63	axoneme assembly (GO:0035082)	2.77854577
64	kynurenine metabolic process (GO:0070189)	2.77568729
65	protein targeting to lysosome (GO:0006622)	2.77017003
66	establishment of protein localization to vacuole (GO:0072666)	2.77017003
67	protein targeting to vacuole (GO:0006623)	2.77017003
68	sympathetic nervous system development (GO:0048485)	2.72779985
69	epithelial tube formation (GO:0072175)	2.71813491
70	DNA double-strand break processing (GO:0000729)	2.70188191
71	positive regulation of mitochondrial membrane permeability (GO:0035794)	2.70098179
72	adenosine metabolic process (GO:0046085)	2.69791007
73	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.69080520
74	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.69080520
75	organelle membrane fusion (GO:0090174)	2.67999964
76	ubiquinone biosynthetic process (GO:0006744)	2.64704759
77	inositol phosphate catabolic process (GO:0071545)	2.64114719
78	negative regulation of systemic arterial blood pressure (GO:0003085)	2.63970978
79	sialylation (GO:0097503)	2.63642340
80	secretory granule organization (GO:0033363)	2.62824109
81	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	2.62781532
82	respiratory chain complex IV assembly (GO:0008535)	2.62385664
83	cardiac ventricle formation (GO:0003211)	2.62195542
84	inner ear receptor stereocilium organization (GO:0060122)	2.59892226
85	quinone biosynthetic process (GO:1901663)	2.59328149
86	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.56939363
87	glycerophospholipid catabolic process (GO:0046475)	2.55224789
88	brain morphogenesis (GO:0048854)	2.53243419
89	lens morphogenesis in camera-type eye (GO:0002089)	2.53025673
90	cardiac chamber formation (GO:0003207)	2.52412715
91	replication fork processing (GO:0031297)	2.52377048
92	keratinocyte development (GO:0003334)	2.51901100
93	lactate metabolic process (GO:0006089)	2.51251792
94	tryptophan metabolic process (GO:0006568)	2.50793608
95	forebrain neuron development (GO:0021884)	2.50634620
96	peroxisome organization (GO:0007031)	2.49695334
97	regulation of fever generation (GO:0031620)	2.49302770
98	negative regulation of axon guidance (GO:1902668)	2.47279539
99	regulation of cilium movement (GO:0003352)	2.45365219
100	limb bud formation (GO:0060174)	10.3572421

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.95283651
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.75959830
3	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	3.13606665
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89065174
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.73971636
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.40161375
7	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.37599566
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.34335228
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.29330255
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.22537951
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.17799107
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.16565436
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.12988351
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.09137427
15	EWS_26573619_Chip-Seq_HEK293_Human	2.07462392
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.06840161
17	P300_19829295_ChIP-Seq_ESCs_Human	2.01277200
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.99448465
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.97711733
20	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.92335086
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.91962484
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.90562516
23	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.78067694
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.77471944
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.76259374
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.76215202
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.72636053
28	FUS_26573619_Chip-Seq_HEK293_Human	1.68160966
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.66499166
30	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.64855947
31	TCF4_22108803_ChIP-Seq_LS180_Human	1.62683340
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.59033111
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55675054
34	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.53624436
35	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.51729382
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.50442641
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48724816
38	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.46808430
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.45103922
40	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.44836315
41	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.44823393
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44762722
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44762722
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.44220534
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.44220534
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.43704682
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.41239403
48	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.40232252
49	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37140253
50	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.35161447
51	STAT3_23295773_ChIP-Seq_U87_Human	1.34301187
52	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.32589945
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.32473942
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.30275406
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28615461
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.28615461
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28346695
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26590950
59	VDR_23849224_ChIP-Seq_CD4+_Human	1.26074337
60	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24992548
61	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.24567256
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23841213
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23155694
64	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.23032122
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.22940510
66	RXR_22108803_ChIP-Seq_LS180_Human	1.21524158
67	TCF4_23295773_ChIP-Seq_U87_Human	1.21288110
68	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20756969
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19762443
70	AR_20517297_ChIP-Seq_VCAP_Human	1.17450029
71	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.15877397
72	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15316710
73	NCOR_22424771_ChIP-Seq_293T_Human	1.14900416
74	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13899343
75	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.13791764
76	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.13104918
77	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.12523303
78	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12497675
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.11741460
80	P53_22387025_ChIP-Seq_ESCs_Mouse	1.11679588
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.11333067
82	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10889081
83	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.09972328
84	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08991898
85	P300_18555785_Chip-Seq_ESCs_Mouse	1.08489494
86	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.07863481
87	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.05854062
88	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05742271
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.04354389
90	IRF1_19129219_ChIP-ChIP_H3396_Human	1.03556987
91	CDX2_22108803_ChIP-Seq_LS180_Human	1.02137223
92	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.01499850
93	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.00576682
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99726279
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99391762
96	AR_25329375_ChIP-Seq_VCAP_Human	0.98396899
97	GATA3_26560356_Chip-Seq_TH2_Human	0.97132178
98	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.96848993
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.96166664
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.95655398

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	4.81466550
2	MP0000569_abnormal_digit_pigmentation	3.75414384
3	MP0005367_renal/urinary_system_phenotyp	3.53064653
4	MP0000516_abnormal_urinary_system	3.53064653
5	MP0005075_abnormal_melanosome_morpholog	3.44684547
6	MP0006054_spinal_hemorrhage	3.43997297
7	MP0003880_abnormal_central_pattern	2.95492385
8	MP0005670_abnormal_white_adipose	2.86385017
9	MP0008872_abnormal_physiological_respon	2.47923513
10	MP0005379_endocrine/exocrine_gland_phen	2.47201632
11	MP0006072_abnormal_retinal_apoptosis	2.44433191
12	MP0003195_calcinosis	2.39873373
13	MP0002254_reproductive_system_inflammat	2.39605389
14	MP0002163_abnormal_gland_morphology	2.36945649
15	MP0010386_abnormal_urinary_bladder	2.32219993
16	MP0005551_abnormal_eye_electrophysiolog	2.29236137
17	MP0008877_abnormal_DNA_methylation	2.21362233
18	MP0002736_abnormal_nociception_after	2.14473238
19	MP0000427_abnormal_hair_cycle	2.09572447
20	MP0002089_abnormal_postnatal_growth/wei	1.97168694
21	MP0004043_abnormal_pH_regulation	1.83804225
22	MP0005253_abnormal_eye_physiology	1.83554004
23	MP0002132_abnormal_respiratory_system	1.82870140
24	MP0002234_abnormal_pharynx_morphology	1.81441444
25	MP0004147_increased_porphyrin_level	1.79886509
26	MP0001756_abnormal_urination	1.79773948
27	MP0002735_abnormal_chemical_nociception	1.71319742
28	MP0001986_abnormal_taste_sensitivity	1.69575366
29	MP0000372_irregular_coat_pigmentation	1.69122796
30	MP0005410_abnormal_fertilization	1.57025659
31	MP0005084_abnormal_gallbladder_morpholo	1.56450284
32	MP0005174_abnormal_tail_pigmentation	1.55580621
33	MP0003718_maternal_effect	1.55083693
34	MP0004742_abnormal_vestibular_system	1.53897579
35	MP0005365_abnormal_bile_salt	1.53007490
36	MP0008775_abnormal_heart_ventricle	1.48678353
37	MP0003191_abnormal_cellular_cholesterol	1.47128641
38	MP0002876_abnormal_thyroid_physiology	1.45519657
39	MP0000538_abnormal_urinary_bladder	1.42836063
40	MP0008875_abnormal_xenobiotic_pharmacok	1.33604577
41	MP0003950_abnormal_plasma_membrane	1.31608052
42	MP0001968_abnormal_touch/_nociception	1.24921657
43	MP0005167_abnormal_blood-brain_barrier	1.17331504
44	MP0001984_abnormal_olfaction	1.17034473
45	MP0001879_abnormal_lymphatic_vessel	1.16342137
46	MP0004215_abnormal_myocardial_fiber	1.14608786
47	MP0006276_abnormal_autonomic_nervous	1.09379772
48	MP0001873_stomach_inflammation	1.08170789
49	MP0005623_abnormal_meninges_morphology	1.07724227
50	MP0004134_abnormal_chest_morphology	1.05083379
51	MP0004019_abnormal_vitamin_homeostasis	1.04446113
52	MP0004142_abnormal_muscle_tone	1.01798329
53	MP0001324_abnormal_eye_pigmentation	0.95943177
54	MP0002102_abnormal_ear_morphology	0.95717336
55	MP0009765_abnormal_xenobiotic_induced	0.94136872
56	MP0008057_abnormal_DNA_replication	0.93298866
57	MP0003868_abnormal_feces_composition	0.90726933
58	MP0000647_abnormal_sebaceous_gland	0.89966916
59	MP0003646_muscle_fatigue	0.88777438
60	MP0005257_abnormal_intraocular_pressure	0.88755238
61	MP0001119_abnormal_female_reproductive	0.87160044
62	MP0002138_abnormal_hepatobiliary_system	0.86921407
63	MP0001764_abnormal_homeostasis	0.86221735
64	MP0003943_abnormal_hepatobiliary_system	0.86089497
65	MP0002909_abnormal_adrenal_gland	0.85963652
66	MP0002075_abnormal_coat/hair_pigmentati	0.84013491
67	MP0006082_CNS_inflammation	0.83872599
68	MP0000383_abnormal_hair_follicle	0.82577488
69	MP0005448_abnormal_energy_balance	0.82316784
70	MP0003011_delayed_dark_adaptation	0.82051651
71	MP0002160_abnormal_reproductive_system	0.80744959
72	MP0003787_abnormal_imprinting	0.80102654
73	MP0004484_altered_response_of	0.78268655
74	MP0002282_abnormal_trachea_morphology	0.77114286
75	MP0003121_genomic_imprinting	0.72703295
76	MP0005646_abnormal_pituitary_gland	0.72246519
77	MP0004145_abnormal_muscle_electrophysio	0.71203805
78	MP0003698_abnormal_male_reproductive	0.71160975
79	MP0003183_abnormal_peptide_metabolism	0.68958259
80	MP0001486_abnormal_startle_reflex	0.68849317
81	MP0004924_abnormal_behavior	0.68503880
82	MP0005386_behavior/neurological_phenoty	0.68503880
83	MP0005423_abnormal_somatic_nervous	0.67994806
84	MP0005266_abnormal_metabolism	0.67176370
85	MP0005389_reproductive_system_phenotype	0.64187330
86	MP0000613_abnormal_salivary_gland	0.63903722
87	MP0000371_diluted_coat_color	0.63706305
88	MP0009703_decreased_birth_body	0.63640373
89	MP0009745_abnormal_behavioral_response	0.63313120
90	MP0005395_other_phenotype	0.62668132
91	MP0005666_abnormal_adipose_tissue	0.61866232
92	MP0002210_abnormal_sex_determination	0.61815760
93	MP0001919_abnormal_reproductive_system	0.61092022
94	MP0003755_abnormal_palate_morphology	0.60620149
95	MP0002653_abnormal_ependyma_morphology	0.60529042
96	MP0004381_abnormal_hair_follicle	0.58666925
97	MP0002752_abnormal_somatic_nervous	0.58589995
98	MP0003137_abnormal_impulse_conducting	0.57762594
99	MP0010329_abnormal_lipoprotein_level	0.57350104
100	MP0003763_abnormal_thymus_physiology	0.55884202

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	5.47981789
2	Long clavicles (HP:0000890)	4.45186642
3	Hepatoblastoma (HP:0002884)	4.06903380
4	Increased density of long bones (HP:0006392)	3.94918691
5	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.91082234
6	Congenital stationary night blindness (HP:0007642)	3.83911469
7	Short phalanx of the thumb (HP:0009660)	3.74905486
8	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	3.73860902
9	Short 1st metacarpal (HP:0010034)	3.73860902
10	Facial hemangioma (HP:0000329)	3.63374768
11	Aplasia/Hypoplasia of the sternum (HP:0006714)	3.61887435
12	Amyotrophic lateral sclerosis (HP:0007354)	3.60273181
13	Tubular atrophy (HP:0000092)	3.54996618
14	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.48353671
15	Pendular nystagmus (HP:0012043)	3.38269329
16	Abnormal rod and cone electroretinograms (HP:0008323)	3.37931074
17	Abnormality of the 1st metacarpal (HP:0010009)	3.23191950
18	Hypoplastic labia majora (HP:0000059)	3.16807718
19	Alacrima (HP:0000522)	3.10888243
20	Severe visual impairment (HP:0001141)	3.05222242
21	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	3.04991776
22	Decreased central vision (HP:0007663)	3.01954150
23	Abnormality of the labia majora (HP:0012881)	2.97065671
24	Abnormality of macular pigmentation (HP:0008002)	2.87040075
25	Medial flaring of the eyebrow (HP:0010747)	2.85653205
26	Attenuation of retinal blood vessels (HP:0007843)	2.84227104
27	Decreased lacrimation (HP:0000633)	2.83728886
28	Stenosis of the external auditory canal (HP:0000402)	2.75120536
29	Broad ribs (HP:0000885)	2.74708363
30	Adactyly (HP:0009776)	2.69097356
31	Widely patent fontanelles and sutures (HP:0004492)	2.68612559
32	Hyperglycinemia (HP:0002154)	2.62370936
33	Hypoplastic nipples (HP:0002557)	2.57870004
34	Bicornuate uterus (HP:0000813)	2.55661976
35	Broad alveolar ridges (HP:0000187)	2.47397876
36	Nephrogenic diabetes insipidus (HP:0009806)	2.46385271
37	Hyperglycinuria (HP:0003108)	2.45556007
38	Labial hypoplasia (HP:0000066)	2.44122435
39	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.41412507
40	Neoplasm of the heart (HP:0100544)	2.40127426
41	Clumsiness (HP:0002312)	2.36790348
42	Abnormality of the pubic bones (HP:0003172)	2.35839444
43	Congenital primary aphakia (HP:0007707)	2.33695238
44	Abnormal hair whorl (HP:0010721)	2.31227726
45	Absent thumb (HP:0009777)	2.30007327
46	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.28523336
47	Hypoplastic female external genitalia (HP:0012815)	2.27768379
48	Small hand (HP:0200055)	2.27317055
49	Hydroureter (HP:0000072)	2.25069660
50	Gait imbalance (HP:0002141)	2.22769366
51	Tongue fasciculations (HP:0001308)	2.18939869
52	Molar tooth sign on MRI (HP:0002419)	2.17634189
53	Abnormality of midbrain morphology (HP:0002418)	2.17634189
54	Scrotal hypoplasia (HP:0000046)	2.09171095
55	Nephronophthisis (HP:0000090)	2.09098593
56	Type 2 muscle fiber atrophy (HP:0003554)	2.06559285
57	Abnormality of glycine metabolism (HP:0010895)	2.03991104
58	Abnormality of serine family amino acid metabolism (HP:0010894)	2.03991104
59	Ureteral stenosis (HP:0000071)	2.01589965
60	Ureteral obstruction (HP:0006000)	2.00044329
61	Short thumb (HP:0009778)	1.99503187
62	Pancreatic cysts (HP:0001737)	1.99446521
63	True hermaphroditism (HP:0010459)	1.98382007
64	Abnormality of the metopic suture (HP:0005556)	1.96709627
65	Limb hypertonia (HP:0002509)	1.96114021
66	Lissencephaly (HP:0001339)	1.95335409
67	Genital tract atresia (HP:0001827)	1.88148489
68	Distal arthrogryposis (HP:0005684)	1.87433723
69	Vaginal atresia (HP:0000148)	1.86251085
70	Retinitis pigmentosa (HP:0000510)	1.82853822
71	Axonal loss (HP:0003447)	1.82097997
72	Muscle fiber atrophy (HP:0100295)	1.80568246
73	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.79107687
74	Short 4th metacarpal (HP:0010044)	1.79107687
75	Macular degeneration (HP:0000608)	1.77989226
76	Pigmentary retinal degeneration (HP:0001146)	1.76669545
77	Abnormality of the renal medulla (HP:0100957)	1.75995248
78	Keratitis (HP:0000491)	1.75307570
79	Muscle fibrillation (HP:0010546)	1.75175211
80	Keratoconus (HP:0000563)	1.74505442
81	Increased corneal curvature (HP:0100692)	1.74505442
82	Pachygyria (HP:0001302)	1.74049242
83	Neoplasm of the oral cavity (HP:0100649)	1.73700396
84	Fair hair (HP:0002286)	1.73188985
85	Visual hallucinations (HP:0002367)	1.72478792
86	Abnormality of dental color (HP:0011073)	1.71975702
87	Mesangial abnormality (HP:0001966)	1.71889837
88	Left ventricular hypertrophy (HP:0001712)	1.70925518
89	Hypoalbuminemia (HP:0003073)	1.70332134
90	Abnormal albumin level (HP:0012116)	1.70332134
91	Hematochezia (HP:0002573)	1.70329008
92	Short foot (HP:0001773)	1.69628565
93	Abnormality of the labia (HP:0000058)	1.69118146
94	Absent speech (HP:0001344)	1.67921042
95	Hypsarrhythmia (HP:0002521)	1.67287971
96	Choroideremia (HP:0001139)	1.67086669
97	Abnormality of the right ventricle (HP:0001707)	1.65686763
98	Hypomagnesemia (HP:0002917)	1.64675747
99	Patellar aplasia (HP:0006443)	1.64530654
100	High pitched voice (HP:0001620)	1.64453509

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	6.58471013
2	PINK1	5.64451429
3	FRK	4.12808655
4	TIE1	3.07574187
5	LMTK2	2.74939556
6	MAPKAPK3	2.73639601
7	NUAK1	2.55113509
8	MUSK	2.24986308
9	ADRBK2	2.04018967
10	GRK1	1.93161350
11	MARK3	1.80524944
12	TLK1	1.77343976
13	TAOK3	1.60285487
14	STK16	1.54002862
15	STK11	1.52323962
16	KDR	1.51822416
17	ERBB3	1.49113611
18	MAPK13	1.48144853
19	PASK	1.46608230
20	MAPKAPK5	1.45313057
21	CAMK1D	1.41325537
22	FGFR2	1.39249148
23	WNK3	1.37480800
24	TRIM28	1.30950726
25	TAF1	1.27700001
26	NEK6	1.27660885
27	ZAK	1.20124602
28	LIMK1	1.17127156
29	EPHA4	1.07160649
30	FER	1.07004303
31	PLK2	1.04517324
32	KSR1	1.03881245
33	PDK2	1.02623100
34	VRK1	1.01808696
35	CAMK1G	0.95625838
36	MINK1	0.94556604
37	PLK3	0.90045310
38	ACVR1B	0.89774569
39	TRPM7	0.85972767
40	TEC	0.83817252
41	TNK2	0.83637630
42	DYRK1B	0.83459029
43	PIK3CG	0.83293864
44	BMPR1B	0.80867814
45	SIK3	0.80070612
46	TXK	0.74255508
47	BCKDK	0.74229483
48	IKBKB	0.74121534
49	CDK8	0.73224411
50	PAK3	0.72676648
51	FLT3	0.70019918
52	PIM1	0.67919391
53	PRKCI	0.67814484
54	WNK4	0.64279842
55	EEF2K	0.63842291
56	MELK	0.61799792
57	VRK2	0.60121853
58	MARK1	0.59810191
59	GRK7	0.58198337
60	PLK4	0.57496311
61	ADRBK1	0.53921234
62	OXSR1	0.53668439
63	PTK2B	0.53362514
64	RPS6KB2	0.52251965
65	INSRR	0.51987485
66	SIK2	0.49360967
67	CAMK1	0.48109945
68	EIF2AK1	0.47020396
69	PRKAA2	0.46844803
70	GRK5	0.45841220
71	MAP3K12	0.44197229
72	IRAK1	0.42806814
73	CSNK1D	0.42430597
74	PRKACA	0.41040850
75	STK39	0.39256793
76	PRKCG	0.39230179
77	TESK2	0.36434933
78	CDK6	0.36033267
79	PRKCZ	0.35896707
80	BRSK2	0.35395952
81	DYRK1A	0.34257026
82	KIT	0.34166699
83	TNIK	0.33680376
84	BMPR2	0.33507161
85	PRKG2	0.31626622
86	TGFBR1	0.30665218
87	BCR	0.30436964
88	ATM	0.30181483
89	TGFBR2	0.29901075
90	MAP3K7	0.29895296
91	PRKD1	0.28910094
92	CAMK4	0.28166681
93	PRKCQ	0.28008874
94	MAP3K4	0.27109766
95	PRKCE	0.25995257
96	ABL1	0.25877809
97	PRKCA	0.25856482
98	DYRK2	0.24725801
99	DAPK1	0.24543052
100	PRKACB	0.24255810

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.11033932
2	Caffeine metabolism_Homo sapiens_hsa00232	3.06653678
3	Basal transcription factors_Homo sapiens_hsa03022	2.97045969
4	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.95620740
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.88798005
6	Ether lipid metabolism_Homo sapiens_hsa00565	2.54629557
7	Propanoate metabolism_Homo sapiens_hsa00640	2.52110473
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.51078730
9	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.44864160
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.25664103
11	Sphingolipid metabolism_Homo sapiens_hsa00600	2.16743796
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.15076228
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.07115050
14	Homologous recombination_Homo sapiens_hsa03440	2.06064339
15	Phototransduction_Homo sapiens_hsa04744	2.02986932
16	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.90603797
17	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.90324460
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.85450870
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.73259647
20	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.70737513
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.68919119
22	Peroxisome_Homo sapiens_hsa04146	1.65228123
23	Protein export_Homo sapiens_hsa03060	1.56651156
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.44173545
25	Folate biosynthesis_Homo sapiens_hsa00790	1.39810654
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.37242027
27	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.36347218
28	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.32709142
29	Parkinsons disease_Homo sapiens_hsa05012	1.27109744
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.23280571
31	Proteasome_Homo sapiens_hsa03050	1.19094405
32	Other glycan degradation_Homo sapiens_hsa00511	1.18861632
33	RNA polymerase_Homo sapiens_hsa03020	1.18291024
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.17799540
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.17333768
36	Nucleotide excision repair_Homo sapiens_hsa03420	1.08246972
37	Collecting duct acid secretion_Homo sapiens_hsa04966	1.04120424
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.02177322
39	One carbon pool by folate_Homo sapiens_hsa00670	1.01147935
40	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.96740942
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.95912571
42	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.94955965
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93310398
44	Glutamatergic synapse_Homo sapiens_hsa04724	0.90606933
45	Retinol metabolism_Homo sapiens_hsa00830	0.89643307
46	Steroid biosynthesis_Homo sapiens_hsa00100	0.86444473
47	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.84162653
48	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.80748011
49	Fatty acid metabolism_Homo sapiens_hsa01212	0.80421775
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80026480
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.77786780
52	Metabolic pathways_Homo sapiens_hsa01100	0.76646191
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.73957887
54	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.73338075
55	Huntingtons disease_Homo sapiens_hsa05016	0.73200673
56	Salivary secretion_Homo sapiens_hsa04970	0.73145043
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.71666734
58	Alzheimers disease_Homo sapiens_hsa05010	0.71297419
59	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.70951156
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.69781492
61	Butanoate metabolism_Homo sapiens_hsa00650	0.69564726
62	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.67612973
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.66432811
64	Taste transduction_Homo sapiens_hsa04742	0.64849957
65	Sulfur metabolism_Homo sapiens_hsa00920	0.58956199
66	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.58629545
67	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57293820
68	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.54727929
69	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.54420145
70	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.54215857
71	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.53810462
72	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.53699428
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.50584239
74	Purine metabolism_Homo sapiens_hsa00230	0.49910434
75	Serotonergic synapse_Homo sapiens_hsa04726	0.49724820
76	Pyruvate metabolism_Homo sapiens_hsa00620	0.48506406
77	Regulation of autophagy_Homo sapiens_hsa04140	0.47695912
78	Mismatch repair_Homo sapiens_hsa03430	0.42338074
79	Pyrimidine metabolism_Homo sapiens_hsa00240	0.42120525
80	Basal cell carcinoma_Homo sapiens_hsa05217	0.41989386
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40556540
82	Fatty acid elongation_Homo sapiens_hsa00062	0.40171098
83	ABC transporters_Homo sapiens_hsa02010	0.39811042
84	Cardiac muscle contraction_Homo sapiens_hsa04260	0.38325470
85	Fatty acid degradation_Homo sapiens_hsa00071	0.35992073
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35907361
87	Rheumatoid arthritis_Homo sapiens_hsa05323	0.34279152
88	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.32023537
89	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.31775542
90	Glutathione metabolism_Homo sapiens_hsa00480	0.29809423
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.29684590
92	Axon guidance_Homo sapiens_hsa04360	0.29538268
93	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.29433930
94	Insulin secretion_Homo sapiens_hsa04911	0.27761855
95	Pancreatic secretion_Homo sapiens_hsa04972	0.24577179
96	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.24341114
97	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.24137373
98	Complement and coagulation cascades_Homo sapiens_hsa04610	0.23974542
99	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.23833094
100	Nicotine addiction_Homo sapiens_hsa05033	0.23175170

NTAN1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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