NTF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1metanephric mesenchyme development (GO:0072075)5.99841422
2kidney mesenchyme development (GO:0072074)5.77963780
3dopamine biosynthetic process (GO:0042416)5.18486597
4collagen fibril organization (GO:0030199)5.00816263
5viral transcription (GO:0019083)4.89607429
6heart valve formation (GO:0003188)4.75043863
7paraxial mesoderm development (GO:0048339)4.71911506
8translational termination (GO:0006415)4.71118425
9outer ear morphogenesis (GO:0042473)4.65325879
10ribosomal small subunit assembly (GO:0000028)4.64581484
11cell migration involved in heart development (GO:0060973)4.56083380
12planar cell polarity pathway involved in neural tube closure (GO:0090179)4.47342992
13type B pancreatic cell proliferation (GO:0044342)4.43445294
14protein heterotrimerization (GO:0070208)4.43200056
15regulation of glomerulus development (GO:0090192)4.40169592
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.39097060
17cotranslational protein targeting to membrane (GO:0006613)4.32955205
18protein targeting to ER (GO:0045047)4.28310675
19glomerulus development (GO:0032835)4.26935647
20mesenchymal-epithelial cell signaling (GO:0060638)4.26605441
21regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.25061199
22maturation of SSU-rRNA (GO:0030490)4.24001160
23mesenchyme morphogenesis (GO:0072132)4.23792395
24alkaloid metabolic process (GO:0009820)4.16460881
25mesonephros development (GO:0001823)4.14700621
26establishment of protein localization to endoplasmic reticulum (GO:0072599)4.09154820
27lymph vessel development (GO:0001945)4.09138220
28regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.06027662
29cell proliferation involved in kidney development (GO:0072111)4.02829352
30heart valve morphogenesis (GO:0003179)4.00742863
31positive regulation of metanephros development (GO:0072216)3.99902268
32pericardium development (GO:0060039)3.99369581
33protein localization to endoplasmic reticulum (GO:0070972)3.97148361
34mesenchymal to epithelial transition (GO:0060231)3.96797098
35regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.89305199
36metanephros development (GO:0001656)3.87589400
37Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.87204565
38endocardial cushion morphogenesis (GO:0003203)3.86661394
39aorta morphogenesis (GO:0035909)3.86660844
40Notch signaling involved in heart development (GO:0061314)3.86462311
41regulation of cell proliferation involved in kidney development (GO:1901722)3.84654401
42cell proliferation involved in metanephros development (GO:0072203)3.79818744
43cellular glucuronidation (GO:0052695)3.79243416
44uronic acid metabolic process (GO:0006063)3.72889601
45glucuronate metabolic process (GO:0019585)3.72889601
46ribosomal small subunit biogenesis (GO:0042274)3.72680588
47translational elongation (GO:0006414)3.70161608
48negative regulation of chondrocyte differentiation (GO:0032331)3.69643310
49cardiac epithelial to mesenchymal transition (GO:0060317)3.67152280
50neuron projection extension involved in neuron projection guidance (GO:1902284)3.67132521
51axon extension involved in axon guidance (GO:0048846)3.67132521
52dopamine transport (GO:0015872)3.64929837
53regulation of establishment of planar polarity (GO:0090175)3.64670818
54cellular protein complex disassembly (GO:0043624)3.64329639
55positive regulation of gastrulation (GO:2000543)3.63163594
56regulation of secondary heart field cardioblast proliferation (GO:0003266)3.61725563
57regulation of cardioblast proliferation (GO:0003264)3.61725563
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.58655141
59negative regulation of axon extension involved in axon guidance (GO:0048843)3.56634970
60negative regulation of osteoblast proliferation (GO:0033689)3.56598729
61skin morphogenesis (GO:0043589)3.54232566
62epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.53844199
63negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.53493393
64non-canonical Wnt signaling pathway (GO:0035567)3.47145554
65viral life cycle (GO:0019058)3.45997942
66convergent extension (GO:0060026)3.41997810
67catecholamine biosynthetic process (GO:0042423)3.39537584
68catechol-containing compound biosynthetic process (GO:0009713)3.39537584
69negative regulation of keratinocyte proliferation (GO:0010839)3.37333596
70extracellular matrix assembly (GO:0085029)3.36880184
71regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.35668226
72endocardial cushion development (GO:0003197)3.35028310
73endodermal cell differentiation (GO:0035987)3.30063570
74cochlea morphogenesis (GO:0090103)3.29957085
75positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.27930539
76regulation of axon extension involved in axon guidance (GO:0048841)3.27754669
77translational initiation (GO:0006413)3.24361129
78negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.21807657
79organ induction (GO:0001759)3.18901555
80mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.18846594
81proximal/distal pattern formation (GO:0009954)3.16979336
82ventricular trabecula myocardium morphogenesis (GO:0003222)3.16061191
83middle ear morphogenesis (GO:0042474)3.15591017
84chaperone-mediated protein transport (GO:0072321)3.14485980
85negative regulation of stem cell proliferation (GO:2000647)3.12706710
86protein targeting to membrane (GO:0006612)3.12114902
87nephron epithelium morphogenesis (GO:0072088)3.10800466
88nephron tubule morphogenesis (GO:0072078)3.10800466
89ribosomal large subunit biogenesis (GO:0042273)3.09013957
90mesenchymal cell development (GO:0014031)3.08416102
91cochlea development (GO:0090102)3.07943744
92norepinephrine metabolic process (GO:0042415)3.07802558
93trabecula formation (GO:0060343)3.06263126
94positive regulation of glomerulus development (GO:0090193)3.05052371
95ureteric bud development (GO:0001657)3.04244678
96protein complex disassembly (GO:0043241)3.04219234
97extracellular fibril organization (GO:0043206)3.01091921
98sequestering of extracellular ligand from receptor (GO:0035581)2.99581285
99left/right pattern formation (GO:0060972)2.98593025
100ventricular septum development (GO:0003281)2.97833066
101cellular response to vitamin (GO:0071295)2.97537516
102regulation of somitogenesis (GO:0014807)2.96902463
103bone trabecula formation (GO:0060346)2.95503864
104regulation of organ formation (GO:0003156)2.95457045
105dopamine metabolic process (GO:0042417)2.94749998
106desmosome organization (GO:0002934)2.93814583
107heart trabecula formation (GO:0060347)2.92707809
108cardiac muscle cell proliferation (GO:0060038)2.91277207
109substrate-dependent cell migration (GO:0006929)2.90545980
110intraciliary transport (GO:0042073)2.89327860
111urogenital system development (GO:0001655)2.88265276
112regulation of non-canonical Wnt signaling pathway (GO:2000050)2.87471987
113inner ear receptor cell development (GO:0060119)2.86570330
114positive regulation of cardiac muscle cell differentiation (GO:2000727)2.86562364
115mesonephric tubule development (GO:0072164)2.86523533
116negative regulation of embryonic development (GO:0045992)2.85352569
117mesonephric epithelium development (GO:0072163)2.85021013
118ATP synthesis coupled proton transport (GO:0015986)2.85002540
119energy coupled proton transport, down electrochemical gradient (GO:0015985)2.85002540
120atrioventricular valve morphogenesis (GO:0003181)2.83185162
121negative regulation of systemic arterial blood pressure (GO:0003085)2.83078190
122macromolecular complex disassembly (GO:0032984)2.82922652
123regulation of axon guidance (GO:1902667)2.82829926
124negative regulation of axon guidance (GO:1902668)2.81954856
125regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.81690280
126positive regulation of cartilage development (GO:0061036)2.81575749
127endothelial cell morphogenesis (GO:0001886)2.81340631
128adhesion of symbiont to host cell (GO:0044650)2.81126645
129virion attachment to host cell (GO:0019062)2.81126645
130regulation of metanephros development (GO:0072215)2.80840104
131neurotransmitter-gated ion channel clustering (GO:0072578)2.79671922
132embryonic forelimb morphogenesis (GO:0035115)2.79664264
133lateral sprouting from an epithelium (GO:0060601)2.79187245
134pharyngeal system development (GO:0060037)2.78438553
135negative regulation of cartilage development (GO:0061037)2.77308933
136anterior/posterior axis specification, embryo (GO:0008595)2.77159468
137head development (GO:0060322)2.76274119
138mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.74538739
139one-carbon compound transport (GO:0019755)2.74196965
140G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.73629398
141mesenchymal cell differentiation involved in kidney development (GO:0072161)2.72383232
142mesenchymal cell differentiation involved in renal system development (GO:2001012)2.72383232
143adrenal gland development (GO:0030325)2.71211415
144cell differentiation involved in kidney development (GO:0061005)2.70415966
145toxin metabolic process (GO:0009404)2.69706277
146midgut development (GO:0007494)2.68305426
147collagen metabolic process (GO:0032963)2.67016195
148cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.66326461
149blood vessel maturation (GO:0001955)2.66207621
150regulation of mesenchymal cell apoptotic process (GO:2001053)2.64380682
151positive regulation of kidney development (GO:0090184)2.63393149
152cardiac ventricle morphogenesis (GO:0003208)2.62971018
153positive regulation of mesonephros development (GO:0061213)2.62424064
154postsynaptic membrane organization (GO:0001941)2.61611580
155lateral ventricle development (GO:0021670)2.61483798
156embryonic skeletal joint morphogenesis (GO:0060272)2.61417495
157respiratory tube development (GO:0030323)2.61290298
158cardiac right ventricle morphogenesis (GO:0003215)2.60689343
159response to insecticide (GO:0017085)2.59544652
160stem cell development (GO:0048864)2.59385895
161forelimb morphogenesis (GO:0035136)2.58923477
162cell differentiation involved in metanephros development (GO:0072202)2.58841407
163negative regulation of smooth muscle cell migration (GO:0014912)2.58366931
164negative regulation of kidney development (GO:0090185)2.57936625
165myelination in peripheral nervous system (GO:0022011)2.57844180
166peripheral nervous system axon ensheathment (GO:0032292)2.57844180
167regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.57041465
168cardiac chamber morphogenesis (GO:0003206)2.56700573
169collagen catabolic process (GO:0030574)2.56522124
170establishment of planar polarity (GO:0001736)2.55218868
171establishment of tissue polarity (GO:0007164)2.55218868
172chondrocyte proliferation (GO:0035988)2.55193085
173regulation of mesonephros development (GO:0061217)2.54463075
174diaphragm development (GO:0060539)2.53738437
175ear development (GO:0043583)2.52792134
176cellular response to BMP stimulus (GO:0071773)2.51506489
177response to BMP (GO:0071772)2.51506489
178ephrin receptor signaling pathway (GO:0048013)2.51358850
179regulation of phospholipase A2 activity (GO:0032429)2.51172778
180negative chemotaxis (GO:0050919)2.51087333
181negative regulation of fibroblast apoptotic process (GO:2000270)2.49742952
182multicellular organismal macromolecule metabolic process (GO:0044259)2.44062463
183lens fiber cell development (GO:0070307)2.41519396
184positive regulation of smoothened signaling pathway (GO:0045880)2.40996332

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.31879930
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.24855032
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.59932552
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.57182145
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.48990452
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.07919376
7EZH2_22144423_ChIP-Seq_EOC_Human2.98427728
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.88814043
9* EED_16625203_ChIP-ChIP_MESCs_Mouse2.83562324
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76932449
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69432904
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61537939
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61537939
14* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58005736
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50556743
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46593363
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46448804
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.42792446
19* BRD4_25478319_ChIP-Seq_HGPS_Human2.42262453
20* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.37201153
21* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34221664
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29516165
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.17663726
24GBX2_23144817_ChIP-Seq_PC3_Human2.15782297
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.13099908
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.01046701
27ESR1_21235772_ChIP-Seq_MCF-7_Human2.00317505
28* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.99569618
29* RNF2_27304074_Chip-Seq_ESCs_Mouse1.97090790
30* EZH2_27294783_Chip-Seq_ESCs_Mouse1.95705572
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90692573
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.89228114
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87351678
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.86346126
35* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84890392
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.83291815
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.81973955
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73324533
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71775713
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.69650914
41TAF15_26573619_Chip-Seq_HEK293_Human1.68853124
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.65664030
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65059614
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64301092
45* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62822208
46* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62340429
47CLOCK_20551151_ChIP-Seq_293T_Human1.61626091
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.61529817
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.61529817
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.61529817
51* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60315407
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56088519
53TP53_18474530_ChIP-ChIP_U2OS_Human1.54950990
54FUS_26573619_Chip-Seq_HEK293_Human1.53282611
55MYC_18555785_ChIP-Seq_MESCs_Mouse1.52342859
56* RING1B_27294783_Chip-Seq_ESCs_Mouse1.47476024
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.47242055
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46916652
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46758828
60* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46213107
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.44840970
62ELK1_19687146_ChIP-ChIP_HELA_Human1.43787095
63* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43657237
64* SA1_22415368_ChIP-Seq_MEFs_Mouse1.43515073
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43296662
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41464071
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.40896035
68TP53_16413492_ChIP-PET_HCT116_Human1.40593498
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38858615
70* RING1B_27294783_Chip-Seq_NPCs_Mouse1.38174491
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.38021302
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.37279843
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37213341
74* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36224572
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34253293
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33744637
77AR_21572438_ChIP-Seq_LNCaP_Human1.33116332
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33027303
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.33020633
80* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30412056
81* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29731310
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29569601
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29233571
84TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.29192257
85TBX3_20139965_ChIP-Seq_ESCs_Mouse1.29062518
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.27986713
87ELK1_22589737_ChIP-Seq_MCF10A_Human1.27918332
88TBX3_20139965_ChIP-Seq_MESCs_Mouse1.27519479
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26919077
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25604176
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25604176
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25589561
93BCAT_22108803_ChIP-Seq_LS180_Human1.24952115
94AHR_22903824_ChIP-Seq_MCF-7_Human1.24268240
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23982770
96EOMES_21245162_ChIP-Seq_HESCs_Human1.20948162
97SOX2_16153702_ChIP-ChIP_HESCs_Human1.20426993
98RNF2_27304074_Chip-Seq_NSC_Mouse1.20388786
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.20330378
100* CDX2_20551321_ChIP-Seq_CACO-2_Human1.19658118
101* SMAD4_21799915_ChIP-Seq_A2780_Human1.18919884
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18357214
103DROSHA_22980978_ChIP-Seq_HELA_Human1.18119954
104* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.16842442
105TCF4_18268006_ChIP-ChIP_LS174T_Human1.15418020
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15058547
107ZNF274_21170338_ChIP-Seq_K562_Hela1.14948274
108POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14529150
109ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14144610
110P300_19829295_ChIP-Seq_ESCs_Human1.13997355
111ISL1_27105846_Chip-Seq_CPCs_Mouse1.13271375
112SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13239214
113TP53_22127205_ChIP-Seq_IMR90_Human1.11215869
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10985655
115* SMAD3_21741376_ChIP-Seq_EPCs_Human1.09835456
116CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09524853
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.09193955
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07924410
119RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07314558
120* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05278028
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05267600
122CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05267570
123RXR_22108803_ChIP-Seq_LS180_Human1.04803104
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04441538
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03357527
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03357527
127MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03230095
128ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02783521
129CJUN_26792858_Chip-Seq_BT549_Human1.01593425
130NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01187800
131* SOX17_20123909_ChIP-Seq_XEN_Mouse1.00598085
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99117935
133* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99022295
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98585084
135PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98391938
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98062686
137SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96574862
138HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95981095
139RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95955720
140SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95921548
141GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95429768
142NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95396614
143HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94279635
144VDR_22108803_ChIP-Seq_LS180_Human0.94035986
145NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91018282
146SOX2_20726797_ChIP-Seq_SW620_Human0.90045968
147OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88917739
148* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87888280
149UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87532744
150CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86987537
151CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85864526
152E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85815740

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.04108734
2MP0002254_reproductive_system_inflammat4.26354616
3MP0003941_abnormal_skin_development3.81294448
4MP0008789_abnormal_olfactory_epithelium3.55151684
5MP0005394_taste/olfaction_phenotype3.48746456
6MP0005499_abnormal_olfactory_system3.48746456
7MP0009379_abnormal_foot_pigmentation3.42169534
8MP0000566_synostosis3.21875526
9MP0005257_abnormal_intraocular_pressure3.08439895
10MP0001958_emphysema3.04360930
11MP0001346_abnormal_lacrimal_gland2.99566020
12MP0005275_abnormal_skin_tensile2.95317081
13MP0010030_abnormal_orbit_morphology2.82971631
14MP0002249_abnormal_larynx_morphology2.59478949
15MP0009053_abnormal_anal_canal2.56527666
16MP0010368_abnormal_lymphatic_system2.46253457
17MP0003942_abnormal_urinary_system2.34424258
18MP0000049_abnormal_middle_ear2.29207668
19MP0009250_abnormal_appendicular_skeleto2.24352947
20MP0000534_abnormal_ureter_morphology2.23385930
21MP0001299_abnormal_eye_distance/2.18209674
22MP0003385_abnormal_body_wall2.17037364
23MP0000762_abnormal_tongue_morphology2.10021217
24MP0004233_abnormal_muscle_weight2.05725137
25MP0002233_abnormal_nose_morphology2.03906492
26MP0001542_abnormal_bone_strength2.03104095
27MP0002653_abnormal_ependyma_morphology1.96051162
28MP0000678_abnormal_parathyroid_gland1.92001716
29MP0004272_abnormal_basement_membrane1.88965986
30MP0001905_abnormal_dopamine_level1.85934199
31MP0006054_spinal_hemorrhage1.78565450
32MP0009384_cardiac_valve_regurgitation1.78106911
33* MP0002108_abnormal_muscle_morphology1.72924242
34MP0003938_abnormal_ear_development1.64174095
35MP0001188_hyperpigmentation1.63037294
36MP0003122_maternal_imprinting1.56549591
37MP0005503_abnormal_tendon_morphology1.55053402
38MP0005377_hearing/vestibular/ear_phenot1.54473326
39MP0003878_abnormal_ear_physiology1.54473326
40MP0005197_abnormal_uvea_morphology1.54161160
41MP0000749_muscle_degeneration1.53647046
42MP0005171_absent_coat_pigmentation1.51714802
43MP0002938_white_spotting1.49280617
44MP0003880_abnormal_central_pattern1.43123246
45MP0001984_abnormal_olfaction1.41571256
46MP0005623_abnormal_meninges_morphology1.40899016
47MP0009780_abnormal_chondrocyte_physiolo1.39520286
48MP0003123_paternal_imprinting1.37672868
49MP0002697_abnormal_eye_size1.37058908
50MP0005508_abnormal_skeleton_morphology1.36541363
51MP0003950_abnormal_plasma_membrane1.34426573
52MP0002332_abnormal_exercise_endurance1.33486576
53MP0001293_anophthalmia1.31257389
54MP0003566_abnormal_cell_adhesion1.30217823
55MP0005187_abnormal_penis_morphology1.29267200
56MP0003937_abnormal_limbs/digits/tail_de1.27020616
57MP0002932_abnormal_joint_morphology1.25597059
58MP0005248_abnormal_Harderian_gland1.24712812
59MP0003755_abnormal_palate_morphology1.24389499
60MP0006292_abnormal_olfactory_placode1.24230462
61MP0003115_abnormal_respiratory_system1.23382482
62* MP0000767_abnormal_smooth_muscle1.23353291
63MP0002877_abnormal_melanocyte_morpholog1.23147227
64MP0001879_abnormal_lymphatic_vessel1.22278618
65MP0002102_abnormal_ear_morphology1.22189472
66MP0002098_abnormal_vibrissa_morphology1.21160024
67MP0000372_irregular_coat_pigmentation1.20789964
68MP0000467_abnormal_esophagus_morphology1.20120960
69MP0003136_yellow_coat_color1.19962855
70MP0000026_abnormal_inner_ear1.18396281
71MP0000751_myopathy1.17009428
72MP0002177_abnormal_outer_ear1.16224081
73MP0004859_abnormal_synaptic_plasticity1.15999298
74MP0000432_abnormal_head_morphology1.12409777
75MP0000579_abnormal_nail_morphology1.11321415
76MP0001286_abnormal_eye_development1.09388456
77MP0001501_abnormal_sleep_pattern1.08819575
78MP0006138_congestive_heart_failure1.06866748
79MP0010386_abnormal_urinary_bladder1.04364307
80MP0001348_abnormal_lacrimal_gland1.02129819
81MP0001270_distended_abdomen1.02048402
82MP0005023_abnormal_wound_healing1.01569256
83MP0000733_abnormal_muscle_development1.01543095
84MP0000538_abnormal_urinary_bladder0.99633365
85MP0001243_abnormal_dermal_layer0.98652845
86MP0002115_abnormal_skeleton_extremities0.98127916
87MP0002896_abnormal_bone_mineralization0.97184723
88MP0004858_abnormal_nervous_system0.96728683
89MP0004133_heterotaxia0.95409254
90MP0001177_atelectasis0.94965143
91MP0000537_abnormal_urethra_morphology0.93437598
92MP0001340_abnormal_eyelid_morphology0.93351462
93MP0004215_abnormal_myocardial_fiber0.90876114
94MP0000613_abnormal_salivary_gland0.89684068
95MP0001485_abnormal_pinna_reflex0.88957801
96MP0005595_abnormal_vascular_smooth0.87817305
97MP0004381_abnormal_hair_follicle0.87103902
98MP0002111_abnormal_tail_morphology0.86069817
99MP0000383_abnormal_hair_follicle0.85404476
100MP0004134_abnormal_chest_morphology0.85106759
101MP0000631_abnormal_neuroendocrine_gland0.84776660
102MP0001849_ear_inflammation0.84312890
103MP0003279_aneurysm0.83082782
104MP0000428_abnormal_craniofacial_morphol0.82856325
105MP0003705_abnormal_hypodermis_morpholog0.82152167
106MP0002282_abnormal_trachea_morphology0.82018745
107MP0000516_abnormal_urinary_system0.81940556
108MP0005367_renal/urinary_system_phenotyp0.81940556
109MP0009840_abnormal_foam_cell0.80708503
110MP0000647_abnormal_sebaceous_gland0.79306190
111MP0003879_abnormal_hair_cell0.78412187
112MP0005193_abnormal_anterior_eye0.78211886
113MP0002092_abnormal_eye_morphology0.77889531
114MP0003121_genomic_imprinting0.77419126
115MP0002796_impaired_skin_barrier0.77337847
116MP0003186_abnormal_redox_activity0.77263589
117MP0000750_abnormal_muscle_regeneration0.76845735
118MP0002060_abnormal_skin_morphology0.76694202
119MP0001963_abnormal_hearing_physiology0.75678723
120MP0002114_abnormal_axial_skeleton0.75671560
121* MP0004085_abnormal_heartbeat0.75634358
122* MP0002295_abnormal_pulmonary_circulatio0.75135205
123MP0002109_abnormal_limb_morphology0.74217525
124MP0004264_abnormal_extraembryonic_tissu0.73187175
125MP0002822_catalepsy0.71564659
126MP0003091_abnormal_cell_migration0.69558779
127MP0006072_abnormal_retinal_apoptosis0.69429849
128* MP0000759_abnormal_skeletal_muscle0.68871297
129MP0004883_abnormal_blood_vessel0.67848346
130MP0003935_abnormal_craniofacial_develop0.67012359
131MP0002085_abnormal_embryonic_tissue0.65646381
132* MP0002127_abnormal_cardiovascular_syste0.64801099
133MP0001919_abnormal_reproductive_system0.64728439
134MP0000639_abnormal_adrenal_gland0.64437492
135MP0002116_abnormal_craniofacial_bone0.64374794
136MP0003315_abnormal_perineum_morphology0.64195996
137MP0000163_abnormal_cartilage_morphology0.64169516
138MP0003119_abnormal_digestive_system0.63907746
139MP0003635_abnormal_synaptic_transmissio0.62457521
140MP0001529_abnormal_vocalization0.62141806
141MP0002132_abnormal_respiratory_system0.61728101
142* MP0010630_abnormal_cardiac_muscle0.61501666
143* MP0002184_abnormal_innervation0.61234001
144* MP0005388_respiratory_system_phenotype0.61152919
145* MP0002133_abnormal_respiratory_system0.61152919

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.54915071
2Protrusio acetabuli (HP:0003179)6.08841408
3Aortic aneurysm (HP:0004942)5.11425890
4Aortic dissection (HP:0002647)4.57582868
5Ankle contracture (HP:0006466)4.56338610
6Abnormality of dentin (HP:0010299)4.48309529
7Limb dystonia (HP:0002451)4.45958424
8Humeroradial synostosis (HP:0003041)4.31477679
9Synostosis involving the elbow (HP:0003938)4.31477679
10Lip pit (HP:0100267)4.01822606
11Type 1 muscle fiber predominance (HP:0003803)3.94081180
12Soft skin (HP:0000977)3.90627572
13Bladder diverticulum (HP:0000015)3.90007914
14Follicular hyperkeratosis (HP:0007502)3.64872767
15Vaginal atresia (HP:0000148)3.59548751
16Genital tract atresia (HP:0001827)3.48176154
17Spinal rigidity (HP:0003306)3.47458765
18Anomalous pulmonary venous return (HP:0010772)3.40513697
19Renal dysplasia (HP:0000110)3.39822165
20Abnormality of the pulmonary veins (HP:0011718)3.37982533
21Morphological abnormality of the middle ear (HP:0008609)3.30353304
22Aplasia involving bones of the extremities (HP:0009825)3.30260755
23Aplasia involving bones of the upper limbs (HP:0009823)3.30260755
24Aplasia of the phalanges of the hand (HP:0009802)3.30260755
25Neonatal short-limb short stature (HP:0008921)3.28890923
26Nasolacrimal duct obstruction (HP:0000579)3.20806268
27Gait imbalance (HP:0002141)3.19376781
28Abnormality of the lacrimal duct (HP:0011481)3.15356989
29Wide anterior fontanel (HP:0000260)3.13070067
30Coronal craniosynostosis (HP:0004440)3.08631210
31Renal duplication (HP:0000075)3.05219068
32Congenital primary aphakia (HP:0007707)3.03408043
33Abnormality of the nasolacrimal system (HP:0000614)3.03121767
34Genu recurvatum (HP:0002816)3.01930565
35Hepatoblastoma (HP:0002884)3.00442431
36Shallow orbits (HP:0000586)3.00403597
37Right ventricular cardiomyopathy (HP:0011663)2.93657933
38Preauricular pit (HP:0004467)2.90966807
39Periauricular skin pits (HP:0100277)2.90966807
40Bowel diverticulosis (HP:0005222)2.90210155
41Mixed hearing impairment (HP:0000410)2.86670162
42Asymmetry of the thorax (HP:0001555)2.85438056
43Fibular aplasia (HP:0002990)2.83162719
44Facial shape deformation (HP:0011334)2.72934926
45Potter facies (HP:0002009)2.72934926
46Nephrogenic diabetes insipidus (HP:0009806)2.71179166
47Hypoplastic left heart (HP:0004383)2.70746599
48Bifid scrotum (HP:0000048)2.69516347
49Abnormality of the phalanges of the 2nd finger (HP:0009541)2.69327824
50Cervical subluxation (HP:0003308)2.68881206
51Slender build (HP:0001533)2.63762908
52Down-sloping shoulders (HP:0200021)2.63572497
53Reticulocytopenia (HP:0001896)2.62429464
54Cutaneous finger syndactyly (HP:0010554)2.61764161
55Atrophic scars (HP:0001075)2.58680966
56Abnormality of the middle phalanges of the toes (HP:0010183)2.57061946
57Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.55957782
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.54413407
59Absent eyebrow (HP:0002223)2.48573100
60Medial flaring of the eyebrow (HP:0010747)2.47688251
61Aortic regurgitation (HP:0001659)2.47599100
62Spondylolisthesis (HP:0003302)2.46914418
63Delayed cranial suture closure (HP:0000270)2.46597866
64Urethral obstruction (HP:0000796)2.46327299
65Calcaneovalgus deformity (HP:0001848)2.46156786
66Partial duplication of the phalanx of hand (HP:0009999)2.45737970
67Deformed tarsal bones (HP:0008119)2.41530010
68Cutaneous syndactyly (HP:0012725)2.38856129
69Stenosis of the external auditory canal (HP:0000402)2.38613596
70Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.37584374
71Fragile skin (HP:0001030)2.37267576
72Short nail (HP:0001799)2.36904215
73Joint laxity (HP:0001388)2.36537578
74Mesangial abnormality (HP:0001966)2.36352611
75Blue sclerae (HP:0000592)2.35686565
76Poor coordination (HP:0002370)2.35091188
77Partial duplication of thumb phalanx (HP:0009944)2.34866253
78Deviation of the hallux (HP:0010051)2.34781841
79Hypoventilation (HP:0002791)2.34210682
80Hyperextensible skin (HP:0000974)2.33172678
81Split foot (HP:0001839)2.31701794
82Broad toe (HP:0001837)2.31394082
83Hydroureter (HP:0000072)2.31134963
84Natal tooth (HP:0000695)2.30083464
85Bronchomalacia (HP:0002780)2.28890754
86Spinal cord lesions (HP:0100561)2.27778952
87Syringomyelia (HP:0003396)2.27778952
88Mitral valve prolapse (HP:0001634)2.27486472
89Turricephaly (HP:0000262)2.26626164
90Skin pits (HP:0100276)2.26518289
91Wormian bones (HP:0002645)2.25671432
92Mesomelia (HP:0003027)2.24516600
93Broad metatarsal (HP:0001783)2.19580193
94Short hallux (HP:0010109)2.19470534
95Hypokinesia (HP:0002375)2.18299865
96Thoracolumbar scoliosis (HP:0002944)2.16985850
97Abnormal delivery (HP:0001787)2.16972114
98Bilateral microphthalmos (HP:0007633)2.16459648
99Broad long bones (HP:0005622)2.15151904
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.15148935
101Abnormal lung lobation (HP:0002101)2.13862436
102Thyroid carcinoma (HP:0002890)2.12735980
103Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.12585800
104Rib fusion (HP:0000902)2.12032575
105Symphalangism affecting the phalanges of the hand (HP:0009773)2.10026886
106Increased variability in muscle fiber diameter (HP:0003557)2.09817258
107Dilatation of the ascending aorta (HP:0005111)2.08757137
108Hypoplastic labia majora (HP:0000059)2.07804730
109Short middle phalanx of the 5th finger (HP:0004220)2.07461229
110Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.07382904
111Redundant skin (HP:0001582)2.05985365
112Cupped ear (HP:0000378)2.03209496
113Arterial tortuosity (HP:0005116)2.02924340
114Mildly elevated creatine phosphokinase (HP:0008180)2.01750751
115Renal hypoplasia (HP:0000089)2.01468610
116Papillary thyroid carcinoma (HP:0002895)2.01240632
117Short 5th finger (HP:0009237)2.00598054
118Duplication of thumb phalanx (HP:0009942)1.99493471
119Short 4th metacarpal (HP:0010044)1.98316972
120Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.98316972
121Generalized amyotrophy (HP:0003700)1.97692676
122Tarsal synostosis (HP:0008368)1.97578553
123Hypodontia (HP:0000668)1.97279683
124Absent eyelashes (HP:0000561)1.96073740
125Mitral regurgitation (HP:0001653)1.94261115
126Synostosis involving bones of the feet (HP:0009140)1.94256353
127Synostosis involving bones of the lower limbs (HP:0009138)1.94256353
128Hallux valgus (HP:0001822)1.91911723
129Aplasia/Hypoplasia of the lens (HP:0008063)1.91090065
130Ectopia lentis (HP:0001083)1.90769721
131Vascular tortuosity (HP:0004948)1.90417937
132Aplasia/Hypoplasia of the hallux (HP:0008362)1.89580504
133Septo-optic dysplasia (HP:0100842)1.89493880
134Pheochromocytoma (HP:0002666)1.88844523
135Abnormality of the phalanges of the 5th finger (HP:0004213)1.88112802
136Hypoplastic heart (HP:0001961)1.87762721
137Synostosis of carpal bones (HP:0005048)1.87063893
138Macrocytic anemia (HP:0001972)1.86792838
139Fibular hypoplasia (HP:0003038)1.85945118
140Neuroendocrine neoplasm (HP:0100634)1.85481701
141Pulmonary artery stenosis (HP:0004415)1.85109482
142Enlarged epiphyses (HP:0010580)1.84483749
143Aplasia/Hypoplasia of the fibula (HP:0006492)1.84407113
144Peritonitis (HP:0002586)1.84377698
145Abnormality of cells of the erythroid lineage (HP:0012130)1.83986160
146Abnormal number of erythroid precursors (HP:0012131)1.82964297
147Broad hallux (HP:0010055)1.80854057
148Abnormality of the labia majora (HP:0012881)1.80111132
149Ventricular tachycardia (HP:0004756)1.79861294
150Broad phalanx (HP:0006009)1.79555952
151Delayed gross motor development (HP:0002194)1.79419480
152Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.78908647
153Abnormality of the phalanges of the hallux (HP:0010057)1.78731876
154Bell-shaped thorax (HP:0001591)1.78717987
155Abnormality of the parietal bone (HP:0002696)1.78067736
156Overgrowth (HP:0001548)1.77708721
157Bifid tongue (HP:0010297)1.77642955
158Limited hip movement (HP:0008800)1.77501574
159Bicornuate uterus (HP:0000813)1.76982168
160Breech presentation (HP:0001623)1.76319563
161Round ear (HP:0100830)1.76294819
162Abnormality of the calf musculature (HP:0001430)1.76273284
163Aplasia of the musculature (HP:0100854)1.75775492
164Limb-girdle muscle weakness (HP:0003325)1.75554560
165Abnormality of the 2nd finger (HP:0004100)1.75114636
166Inguinal hernia (HP:0000023)1.75039891
167Camptodactyly of toe (HP:0001836)1.74819432
168Long toe (HP:0010511)1.73557627
169Broad foot (HP:0001769)1.73478845
170Abnormality of the pubic bones (HP:0003172)1.73175106
171Dental crowding (HP:0000678)1.72917111
172Abnormality of the acetabulum (HP:0003170)1.72629384
173Abnormality of carpal bone ossification (HP:0006257)1.71095630
174Abnormality of skeletal muscle fiber size (HP:0012084)1.67534143
175Flat cornea (HP:0007720)1.66324633
176Broad thumb (HP:0011304)1.63457440
177Biconcave vertebral bodies (HP:0004586)1.62374871
178Pterygium (HP:0001059)1.61035878
179Vertebral compression fractures (HP:0002953)1.60096885
180Abnormal ossification of hand bones (HP:0005921)1.58636399
181Hip contracture (HP:0003273)1.56508536
182Mild short stature (HP:0003502)1.55110130
183Premature skin wrinkling (HP:0100678)1.54812258

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.96499395
2ERBB33.46586275
3PIK3CG3.29895308
4DDR23.23835141
5MAPKAPK53.05850447
6STK162.88985649
7EPHB22.83378213
8MYLK2.75126125
9PTK2B2.60532531
10ERN12.32568102
11GRK52.17926099
12PAK22.04154040
13NEK92.04114384
14MUSK1.99496466
15PLK21.98770644
16TGFBR11.95683991
17ZAK1.88297406
18LIMK11.75464395
19WNK41.71892675
20DAPK31.71762014
21GRK71.70471529
22CDK81.69630117
23AKT31.68137473
24MAP3K21.68040380
25NTRK11.57710108
26GRK11.57700979
27CASK1.55824624
28ADRBK21.50583319
29LRRK21.50384004
30STK391.49533459
31LATS21.48174379
32SGK21.39842450
33PAK41.39387570
34WNK11.38187961
35ILK1.37511203
36NME11.36336071
37MAP3K31.34330505
38SIK31.26670785
39GRK61.24719938
40TAF11.22279883
41BMPR1B1.22038795
42TIE11.21316236
43BMPR21.19775474
44STK38L1.18734163
45NTRK31.16986844
46MAPK71.15688642
47PRKD31.14225524
48PIK3CA1.13670225
49PNCK1.12919297
50FLT31.11540203
51PAK31.09429123
52NUAK11.07652345
53MAP3K121.07421945
54MINK11.06998703
55SGK4941.00386013
56SGK2231.00386013
57MAP3K71.00384515
58PRKD20.99314338
59DYRK20.99281758
60PDGFRA0.98448586
61DAPK20.98303614
62ROCK10.97572691
63CAMK2B0.97217559
64CAMK2A0.96908336
65EPHA40.96878925
66BCKDK0.93784950
67MELK0.92834404
68PHKG10.92132298
69PHKG20.92132298
70PASK0.90805495
71PTK20.90596429
72TLK10.90468941
73MARK10.89704585
74TAOK20.89436488
75CAMK10.89270020
76FGR0.88235082
77MKNK20.87767666
78ABL20.87309258
79TTN0.86314288
80BCR0.85977696
81ADRBK10.85716111
82PBK0.85714091
83KSR10.84486227
84CAMK2G0.83718741
85STK380.82358288
86PRKG20.81694195
87PDGFRB0.80918687
88ROCK20.80483720
89VRK10.79641257
90MST40.78121244
91STK30.76114856
92CAMK2D0.74598105
93PAK10.74133529
94PKN20.74111495
95TTK0.70817953
96PRPF4B0.70617129
97TGFBR20.69828587
98ERBB40.69756239
99PDK20.69738249
100PAK60.69573593
101MAP2K40.68380858
102AURKB0.68181928
103MAP2K10.67811819
104RET0.67452299
105FGFR10.67394849
106WNK30.67306800
107DYRK1B0.66642002
108RIPK10.65977141
109LATS10.65851276
110CDK90.65079863
111SGK30.64433285
112CAMK40.62445691
113DYRK1A0.62232559
114PRKCE0.61006407
115RPS6KA20.59838442
116CDK180.59751164
117OBSCN0.59167741
118RPS6KC10.58096216
119RPS6KL10.58096216
120CDK190.57110937
121PINK10.56781793
122MAPKAPK20.56292358
123TESK10.54900173
124MET0.54729503
125CDK50.54514045
126TRPM70.54179742
127CDC42BPA0.51558080
128CHEK20.51411357
129NEK20.51080362
130DYRK30.50259543
131FGFR20.49025002
132CDK150.48323785
133NEK60.47824249
134TRIB30.47316295
135MKNK10.46255522
136DMPK0.46221779
137EIF2AK10.45938186
138RPS6KA60.45688905
139MOS0.45261711
140GSK3A0.44528743
141FER0.43367135
142FRK0.43183955
143PRKCG0.43166193
144BRD40.43050131
145BRAF0.42187327
146ERBB20.41805375
147PLK30.41645031
148CDK11A0.41175129
149PLK10.40336469
150YES10.39968635
151MTOR0.34871963
152CDK70.34179110
153CDC70.29786862

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.91839039
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.21182275
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.09337524
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.91699328
5Chemical carcinogenesis_Homo sapiens_hsa052042.73740003
6Protein export_Homo sapiens_hsa030602.41674642
7Steroid hormone biosynthesis_Homo sapiens_hsa001402.39778736
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.36059958
9Retinol metabolism_Homo sapiens_hsa008302.29642815
10Cocaine addiction_Homo sapiens_hsa050302.29245331
11Amphetamine addiction_Homo sapiens_hsa050312.20870784
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.20072692
13Proteasome_Homo sapiens_hsa030502.13942291
14Axon guidance_Homo sapiens_hsa043602.00335552
15Basal cell carcinoma_Homo sapiens_hsa052171.92359593
16Protein digestion and absorption_Homo sapiens_hsa049741.84397366
17Parkinsons disease_Homo sapiens_hsa050121.71203302
18Renin secretion_Homo sapiens_hsa049241.60990057
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.58498652
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53347305
21Tyrosine metabolism_Homo sapiens_hsa003501.52381364
22Melanogenesis_Homo sapiens_hsa049161.50725472
23Dilated cardiomyopathy_Homo sapiens_hsa054141.49713389
24Thyroid cancer_Homo sapiens_hsa052161.48729958
25Hippo signaling pathway_Homo sapiens_hsa043901.46659650
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.45411144
27N-Glycan biosynthesis_Homo sapiens_hsa005101.44076352
28Oxidative phosphorylation_Homo sapiens_hsa001901.43153509
29Circadian entrainment_Homo sapiens_hsa047131.43014070
30Dopaminergic synapse_Homo sapiens_hsa047281.34552424
31Gap junction_Homo sapiens_hsa045401.33544383
32Mismatch repair_Homo sapiens_hsa034301.33316055
33Phenylalanine metabolism_Homo sapiens_hsa003601.31727548
34Alzheimers disease_Homo sapiens_hsa050101.31122619
35RNA polymerase_Homo sapiens_hsa030201.29061037
36ECM-receptor interaction_Homo sapiens_hsa045121.25343029
37Calcium signaling pathway_Homo sapiens_hsa040201.23597764
38One carbon pool by folate_Homo sapiens_hsa006701.21466809
39Starch and sucrose metabolism_Homo sapiens_hsa005001.21026999
40Nicotine addiction_Homo sapiens_hsa050331.18322486
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17668912
42Hedgehog signaling pathway_Homo sapiens_hsa043401.16509520
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16286837
44TGF-beta signaling pathway_Homo sapiens_hsa043501.15742327
45Serotonergic synapse_Homo sapiens_hsa047261.15534665
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11546372
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.11425845
48Cardiac muscle contraction_Homo sapiens_hsa042601.11079265
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09761614
50Glutathione metabolism_Homo sapiens_hsa004801.07648315
51Nucleotide excision repair_Homo sapiens_hsa034201.07110401
52Circadian rhythm_Homo sapiens_hsa047101.04177309
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04164004
54Selenocompound metabolism_Homo sapiens_hsa004501.01979211
55Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01523467
56Long-term potentiation_Homo sapiens_hsa047200.98818169
57Fatty acid elongation_Homo sapiens_hsa000620.98187931
58Salivary secretion_Homo sapiens_hsa049700.97563800
59PI3K-Akt signaling pathway_Homo sapiens_hsa041510.96545355
60Bladder cancer_Homo sapiens_hsa052190.94544223
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94089750
62Synaptic vesicle cycle_Homo sapiens_hsa047210.93104948
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93043059
64Cholinergic synapse_Homo sapiens_hsa047250.92479242
65Long-term depression_Homo sapiens_hsa047300.91500062
66Proteoglycans in cancer_Homo sapiens_hsa052050.89411720
67Folate biosynthesis_Homo sapiens_hsa007900.89119241
68GnRH signaling pathway_Homo sapiens_hsa049120.88234606
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87571558
70Adherens junction_Homo sapiens_hsa045200.87348492
71Oxytocin signaling pathway_Homo sapiens_hsa049210.85609807
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85590148
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.84318111
74p53 signaling pathway_Homo sapiens_hsa041150.83594121
75cAMP signaling pathway_Homo sapiens_hsa040240.82518987
76Olfactory transduction_Homo sapiens_hsa047400.81608476
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81394109
78Glutamatergic synapse_Homo sapiens_hsa047240.81162705
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.81007948
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80595804
81Wnt signaling pathway_Homo sapiens_hsa043100.80466275
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80223317
83Huntingtons disease_Homo sapiens_hsa050160.79693933
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78964899
85Gastric acid secretion_Homo sapiens_hsa049710.78352504
86Pyrimidine metabolism_Homo sapiens_hsa002400.76447956
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74674997
88Dorso-ventral axis formation_Homo sapiens_hsa043200.71199059
89Mineral absorption_Homo sapiens_hsa049780.70834375
90DNA replication_Homo sapiens_hsa030300.70612207
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70398802
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68004602
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.67834226
94Focal adhesion_Homo sapiens_hsa045100.67759308
95Butanoate metabolism_Homo sapiens_hsa006500.67600074
96Estrogen signaling pathway_Homo sapiens_hsa049150.67035071
97Fatty acid metabolism_Homo sapiens_hsa012120.66305255
98GABAergic synapse_Homo sapiens_hsa047270.65650025
99Melanoma_Homo sapiens_hsa052180.65230711
100Spliceosome_Homo sapiens_hsa030400.64830444
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64324634
102Purine metabolism_Homo sapiens_hsa002300.64149747
103Propanoate metabolism_Homo sapiens_hsa006400.64064975
104Tight junction_Homo sapiens_hsa045300.63162331
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.62632540
106Notch signaling pathway_Homo sapiens_hsa043300.62368556
107Small cell lung cancer_Homo sapiens_hsa052220.62006968
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61857267
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61138575
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.61023208
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60237043
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57606613
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57540413
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55151183
115MicroRNAs in cancer_Homo sapiens_hsa052060.55044876
116Rap1 signaling pathway_Homo sapiens_hsa040150.54298195
117Prostate cancer_Homo sapiens_hsa052150.52545570
118Sulfur metabolism_Homo sapiens_hsa009200.49929103
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49917021
120Complement and coagulation cascades_Homo sapiens_hsa046100.49704879
121Carbon metabolism_Homo sapiens_hsa012000.49391324
122Metabolic pathways_Homo sapiens_hsa011000.48170981
123Collecting duct acid secretion_Homo sapiens_hsa049660.48031070
124Fructose and mannose metabolism_Homo sapiens_hsa000510.46758272
125Insulin secretion_Homo sapiens_hsa049110.46656459
126Fanconi anemia pathway_Homo sapiens_hsa034600.45041500
127Homologous recombination_Homo sapiens_hsa034400.43929036
128Taste transduction_Homo sapiens_hsa047420.43921640
129Fatty acid degradation_Homo sapiens_hsa000710.43810720
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43661825
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.42465273
132Basal transcription factors_Homo sapiens_hsa030220.42049421
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41934028
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41412257
135Amoebiasis_Homo sapiens_hsa051460.41324004
136Vibrio cholerae infection_Homo sapiens_hsa051100.41138908
137Glioma_Homo sapiens_hsa052140.40986135
138Vitamin digestion and absorption_Homo sapiens_hsa049770.40819726
139RNA transport_Homo sapiens_hsa030130.40317381
140Pentose phosphate pathway_Homo sapiens_hsa000300.40257261
141Galactose metabolism_Homo sapiens_hsa000520.39717332
142Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39307389
143Pathways in cancer_Homo sapiens_hsa052000.39272214
144African trypanosomiasis_Homo sapiens_hsa051430.39017327
145Nitrogen metabolism_Homo sapiens_hsa009100.38360231
146Morphine addiction_Homo sapiens_hsa050320.37946227
147Biosynthesis of amino acids_Homo sapiens_hsa012300.37789009
148Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37528604
149RNA degradation_Homo sapiens_hsa030180.35244749
150Cell cycle_Homo sapiens_hsa041100.34159936
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33959825

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