NTF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.47986416
2hemidesmosome assembly (GO:0031581)7.93065408
3bundle of His cell to Purkinje myocyte communication (GO:0086069)6.20738468
4keratinocyte proliferation (GO:0043616)6.10857986
5actin-myosin filament sliding (GO:0033275)5.21195915
6muscle filament sliding (GO:0030049)5.21195915
7negative regulation of keratinocyte proliferation (GO:0010839)4.98776032
8regulation of water loss via skin (GO:0033561)4.89109137
9establishment of skin barrier (GO:0061436)4.62823817
10regulation of transforming growth factor beta2 production (GO:0032909)4.42134065
11plasma membrane repair (GO:0001778)4.37802715
12actin-mediated cell contraction (GO:0070252)4.37731411
13cell-substrate junction assembly (GO:0007044)4.23931396
14skeletal muscle contraction (GO:0003009)4.20453351
15sarcoplasmic reticulum calcium ion transport (GO:0070296)4.10797439
16notochord development (GO:0030903)3.82733706
17keratinocyte development (GO:0003334)3.82616743
18gap junction assembly (GO:0016264)3.82099821
19sarcomere organization (GO:0045214)3.74987763
20regulation of keratinocyte proliferation (GO:0010837)3.71265677
21paraxial mesoderm development (GO:0048339)3.63549070
22regulation of hair follicle development (GO:0051797)3.49974095
23polarized epithelial cell differentiation (GO:0030859)3.48745599
24planar cell polarity pathway involved in neural tube closure (GO:0090179)3.47105995
25actin filament-based movement (GO:0030048)3.46226922
26motile cilium assembly (GO:0044458)3.45401577
27regulation of mitochondrial translation (GO:0070129)3.44265140
28multicellular organismal water homeostasis (GO:0050891)3.39689148
29response to muscle activity (GO:0014850)3.38128528
30focal adhesion assembly (GO:0048041)3.36895216
31cell-substrate adherens junction assembly (GO:0007045)3.36895216
32establishment of tissue polarity (GO:0007164)3.30209964
33establishment of planar polarity (GO:0001736)3.30209964
34positive regulation of epidermis development (GO:0045684)3.26764597
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.26277131
36galactose catabolic process (GO:0019388)3.22328237
37positive regulation of hair cycle (GO:0042635)3.20664862
38positive regulation of hair follicle development (GO:0051798)3.20664862
39skeletal muscle tissue regeneration (GO:0043403)3.18891604
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.16183451
41dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.08588167
42negative regulation of stem cell proliferation (GO:2000647)3.08271585
43regulation of skeletal muscle contraction (GO:0014819)3.06704544
44branching involved in salivary gland morphogenesis (GO:0060445)3.05539577
45regulation of cardioblast differentiation (GO:0051890)3.01737792
46positive regulation of epidermal cell differentiation (GO:0045606)2.99937479
47myofibril assembly (GO:0030239)2.96304076
48lateral sprouting from an epithelium (GO:0060601)2.94360680
49adherens junction assembly (GO:0034333)2.92419347
50establishment of apical/basal cell polarity (GO:0035089)2.86944788
51striated muscle contraction (GO:0006941)2.86489213
52glycogen catabolic process (GO:0005980)2.85896928
53keratinization (GO:0031424)2.84928164
54otic vesicle formation (GO:0030916)2.84748440
55regulation of G0 to G1 transition (GO:0070316)2.83959289
56apical protein localization (GO:0045176)2.80908972
57non-canonical Wnt signaling pathway (GO:0035567)2.71722917
58asymmetric protein localization (GO:0008105)2.71260182
59* epidermis development (GO:0008544)2.69581668
60water homeostasis (GO:0030104)2.69442265
61actomyosin structure organization (GO:0031032)2.68759714
62cardiac right ventricle morphogenesis (GO:0003215)2.67325183
63skeletal muscle fiber development (GO:0048741)2.66474903
64regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.66037165
65skin development (GO:0043588)2.65487248
66negative regulation of cell fate specification (GO:0009996)2.64467774
67regulation of gene silencing by miRNA (GO:0060964)2.63996704
68regulation of gene silencing by RNA (GO:0060966)2.63996704
69regulation of posttranscriptional gene silencing (GO:0060147)2.63996704
70protein autoprocessing (GO:0016540)2.62428310
71ventricular cardiac muscle cell action potential (GO:0086005)2.61383179
72establishment of protein localization to mitochondrial membrane (GO:0090151)2.60839489
73intermediate filament cytoskeleton organization (GO:0045104)2.60615083
74tight junction assembly (GO:0070830)2.60572456
75morphogenesis of embryonic epithelium (GO:0016331)2.60017198
76keratinocyte differentiation (GO:0030216)2.59913042
77epithelial cell-cell adhesion (GO:0090136)2.59483826
78cardiac myofibril assembly (GO:0055003)2.58442170
79glucan catabolic process (GO:0009251)2.56283017
80G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.55791903
81intermediate filament-based process (GO:0045103)2.54824466
82regulation of relaxation of muscle (GO:1901077)2.54771259
83ribosomal small subunit biogenesis (GO:0042274)2.54620174
84bone trabecula formation (GO:0060346)2.50562374
85molting cycle (GO:0042303)2.49949881
86hair cycle (GO:0042633)2.49949881
87ribosomal large subunit biogenesis (GO:0042273)2.49918690
88epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49201644
89glycogen biosynthetic process (GO:0005978)2.48776998
90glucan biosynthetic process (GO:0009250)2.48776998
91atrioventricular valve morphogenesis (GO:0003181)2.46899782
92regulation of epidermis development (GO:0045682)2.46264597
93negative regulation of cartilage development (GO:0061037)2.46231462
94intermediate filament organization (GO:0045109)2.45887476
95respiratory electron transport chain (GO:0022904)2.45542475
96muscle tissue morphogenesis (GO:0060415)2.44450097
97cardiac muscle tissue morphogenesis (GO:0055008)2.43536472
98hippo signaling (GO:0035329)2.43175059
99semaphorin-plexin signaling pathway (GO:0071526)2.43045422
100proteasome assembly (GO:0043248)2.42585216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.93314763
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.97081668
3ZNF263_19887448_ChIP-Seq_K562_Human3.93375694
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.74117588
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.30137598
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.00838662
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.35046406
8* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.29925504
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.17718135
10E2F7_22180533_ChIP-Seq_HELA_Human1.99217438
11KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.98423854
12RACK7_27058665_Chip-Seq_MCF-7_Human1.93759716
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89597482
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87191864
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.78270234
16SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.78270234
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.75067606
18MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73671632
19MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70484897
20ERG_21242973_ChIP-ChIP_JURKAT_Human1.70235211
21ATF3_27146783_Chip-Seq_COLON_Human1.69957998
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.68195801
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67463401
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67233875
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63767962
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.62942864
27SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55156496
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54406148
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.54250590
30KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50673759
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50613337
32AR_21909140_ChIP-Seq_LNCAP_Human1.46844107
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43982612
34KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43014859
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.42445832
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38806370
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38608433
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.38233251
39TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37034023
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36168724
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35135475
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34298626
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.32925425
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31020216
45NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30825106
46UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28650938
47* TP63_22573176_ChIP-Seq_HFKS_Human1.28172247
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25038314
49CTCF_27219007_Chip-Seq_Bcells_Human1.24822014
50DCP1A_22483619_ChIP-Seq_HELA_Human1.24108606
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23180479
52KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23180479
53KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23180479
54SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22606122
55LXR_22292898_ChIP-Seq_THP-1_Human1.21800099
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18433707
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17410215
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16445059
59NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.16190304
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15284153
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14648829
62GATA6_25053715_ChIP-Seq_YYC3_Human1.14538002
63UBF1/2_26484160_Chip-Seq_HMECs_Human1.14530786
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13296644
65GATA3_24758297_ChIP-Seq_MCF-7_Human1.11739350
66EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11186325
67SMC4_20622854_ChIP-Seq_HELA_Human1.05302268
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.05207754
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03567619
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03191752
71XRN2_22483619_ChIP-Seq_HELA_Human1.02624264
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02140153
73EOMES_21245162_ChIP-Seq_HESCs_Human1.01603895
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01119223
75SA1_27219007_Chip-Seq_ERYTHROID_Human0.99981125
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99313365
77SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99139436
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98809876
79TET1_21451524_ChIP-Seq_MESCs_Mouse0.98401405
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98377125
81KLF5_25053715_ChIP-Seq_YYC3_Human0.98227924
82STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97922649
83OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97913657
84NANOG_18692474_ChIP-Seq_MEFs_Mouse0.97297331
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94721464
86TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94305593
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93266417
88TBX20_22328084_ChIP-Seq_HEART_Mouse0.92101452
89TBX20_22080862_ChIP-Seq_HEART_Mouse0.92101452
90CLOCK_20551151_ChIP-Seq_293T_Human0.91550715
91ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90404764
92STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.89376289
93ELK3_25401928_ChIP-Seq_HUVEC_Human0.89307289
94P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88644649
95CHD1_26751641_Chip-Seq_LNCaP_Human0.88410074
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88179134
97SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87117046
98ETS1_20019798_ChIP-Seq_JURKAT_Human0.86300221
99CREB1_15753290_ChIP-ChIP_HEK293T_Human0.85072706
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.84827541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology4.87100493
2MP0003941_abnormal_skin_development4.16867298
3MP0010234_abnormal_vibrissa_follicle4.05848178
4MP0002796_impaired_skin_barrier3.17255106
5MP0000566_synostosis2.63716219
6MP0004264_abnormal_extraembryonic_tissu2.62569781
7MP0010030_abnormal_orbit_morphology2.62278538
8MP0000751_myopathy2.60059525
9MP0000762_abnormal_tongue_morphology2.55479960
10MP0003878_abnormal_ear_physiology2.54184036
11MP0005377_hearing/vestibular/ear_phenot2.54184036
12MP0003705_abnormal_hypodermis_morpholog2.35933471
13MP0002098_abnormal_vibrissa_morphology2.32571933
14MP0005501_abnormal_skin_physiology2.22511902
15MP0000467_abnormal_esophagus_morphology2.20763037
16MP0000749_muscle_degeneration2.11526674
17MP0009379_abnormal_foot_pigmentation2.05244835
18MP0003453_abnormal_keratinocyte_physiol2.04706322
19MP0010678_abnormal_skin_adnexa2.03598449
20MP0004145_abnormal_muscle_electrophysio2.01742080
21MP0003566_abnormal_cell_adhesion2.00570723
22MP0001216_abnormal_epidermal_layer1.87929497
23MP0005451_abnormal_body_composition1.83579617
24MP0005275_abnormal_skin_tensile1.82507477
25MP0000383_abnormal_hair_follicle1.80496100
26MP0002060_abnormal_skin_morphology1.77881678
27MP0004036_abnormal_muscle_relaxation1.76670059
28MP0009053_abnormal_anal_canal1.75262235
29MP0004233_abnormal_muscle_weight1.73731744
30MP0003646_muscle_fatigue1.70951850
31MP0005330_cardiomyopathy1.61362721
32MP0000750_abnormal_muscle_regeneration1.59406370
33MP0000377_abnormal_hair_follicle1.59187223
34MP0001849_ear_inflammation1.57994290
35MP0000427_abnormal_hair_cycle1.57515069
36MP0004087_abnormal_muscle_fiber1.54910930
37MP0002234_abnormal_pharynx_morphology1.53793179
38MP0000759_abnormal_skeletal_muscle1.46117602
39MP0000747_muscle_weakness1.40234915
40MP0005023_abnormal_wound_healing1.38791602
41MP0010771_integument_phenotype1.38612391
42MP0002106_abnormal_muscle_physiology1.31838653
43MP0004084_abnormal_cardiac_muscle1.30852784
44MP0004272_abnormal_basement_membrane1.30826719
45MP0000647_abnormal_sebaceous_gland1.30196841
46MP0002269_muscular_atrophy1.25620335
47MP0000733_abnormal_muscle_development1.24305813
48MP0004185_abnormal_adipocyte_glucose1.24059700
49MP0000678_abnormal_parathyroid_gland1.20785600
50MP0004381_abnormal_hair_follicle1.19494969
51MP0005369_muscle_phenotype1.18547096
52MP0001299_abnormal_eye_distance/1.16359869
53MP0000537_abnormal_urethra_morphology1.16033762
54MP0002697_abnormal_eye_size1.11642566
55MP0009780_abnormal_chondrocyte_physiolo1.11347668
56MP0004043_abnormal_pH_regulation1.06117527
57MP0003315_abnormal_perineum_morphology1.05248485
58MP0000627_abnormal_mammary_gland1.02055475
59MP0006292_abnormal_olfactory_placode1.01636522
60MP0003755_abnormal_palate_morphology1.00529193
61MP0005620_abnormal_muscle_contractility1.00501508
62MP0002332_abnormal_exercise_endurance0.99498349
63MP0010630_abnormal_cardiac_muscle0.98978855
64MP0003806_abnormal_nucleotide_metabolis0.96626018
65MP0001346_abnormal_lacrimal_gland0.95138721
66MP0008789_abnormal_olfactory_epithelium0.94576670
67MP0002972_abnormal_cardiac_muscle0.93949051
68MP0009672_abnormal_birth_weight0.92335550
69MP0005248_abnormal_Harderian_gland0.92036373
70MP0002249_abnormal_larynx_morphology0.88397907
71MP0003693_abnormal_embryo_hatching0.88198441
72MP0009931_abnormal_skin_appearance0.85486131
73MP0003136_yellow_coat_color0.85482376
74MP0004957_abnormal_blastocyst_morpholog0.85221141
75MP0001340_abnormal_eyelid_morphology0.84517013
76MP0003937_abnormal_limbs/digits/tail_de0.83601734
77MP0006036_abnormal_mitochondrial_physio0.83203799
78MP0008932_abnormal_embryonic_tissue0.82627823
79MP0001881_abnormal_mammary_gland0.80972861
80MP0005076_abnormal_cell_differentiation0.80713053
81MP0002111_abnormal_tail_morphology0.79385481
82MP0002108_abnormal_muscle_morphology0.78517298
83MP0003950_abnormal_plasma_membrane0.78376325
84MP0004197_abnormal_fetal_growth/weight/0.78299550
85MP0002233_abnormal_nose_morphology0.78112348
86MP0010352_gastrointestinal_tract_polyps0.77842503
87MP0004782_abnormal_surfactant_physiolog0.76962247
88MP0006138_congestive_heart_failure0.76282970
89MP0000013_abnormal_adipose_tissue0.76098522
90MP0001293_anophthalmia0.74107076
91MP0003385_abnormal_body_wall0.71654112
92MP0003942_abnormal_urinary_system0.69929334
93MP0000432_abnormal_head_morphology0.69828718
94MP0005409_darkened_coat_color0.69080461
95MP0003890_abnormal_embryonic-extraembry0.68968847
96MP0001730_embryonic_growth_arrest0.68461695
97MP0004215_abnormal_myocardial_fiber0.68439839
98MP0004133_heterotaxia0.67285309
99MP0010307_abnormal_tumor_latency0.63870992
100MP0005083_abnormal_biliary_tract0.63221308

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)6.31992094
2Muscle fiber inclusion bodies (HP:0100299)6.24766279
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.07640681
4Fragile nails (HP:0001808)5.10430824
5Exercise-induced muscle cramps (HP:0003710)4.74639375
6Right ventricular cardiomyopathy (HP:0011663)4.69409755
7Type 1 muscle fiber predominance (HP:0003803)4.49531507
8Nonprogressive disorder (HP:0003680)4.41954368
9Exercise-induced myalgia (HP:0003738)4.37438364
10Milia (HP:0001056)4.06924499
11Plantar hyperkeratosis (HP:0007556)3.94402618
12Alopecia of scalp (HP:0002293)3.72901093
13Abnormality of nail color (HP:0100643)3.63455126
14Onycholysis (HP:0001806)3.55093231
15Myopathic facies (HP:0002058)3.39975796
16Distal lower limb muscle weakness (HP:0009053)3.34404198
17Ulnar deviation of the wrist (HP:0003049)3.30506096
18Selective tooth agenesis (HP:0001592)3.27650594
19Ventricular tachycardia (HP:0004756)3.21600153
20Atrophic scars (HP:0001075)3.18946444
21Pili torti (HP:0003777)3.18358904
22Palmoplantar hyperkeratosis (HP:0000972)3.10392824
23Pterygium (HP:0001059)2.99617203
24Woolly hair (HP:0002224)2.96315682
25Palmar hyperkeratosis (HP:0010765)2.93801184
26Increased connective tissue (HP:0009025)2.93007480
27Centrally nucleated skeletal muscle fibers (HP:0003687)2.92724837
28Popliteal pterygium (HP:0009756)2.92510401
29Abnormality of placental membranes (HP:0011409)2.86985426
30Amniotic constriction ring (HP:0009775)2.86985426
31Distal arthrogryposis (HP:0005684)2.84286872
32Abnormal hair laboratory examination (HP:0003328)2.79370533
33Muscle hypertrophy of the lower extremities (HP:0008968)2.76565812
34Abnormality of the dental root (HP:0006486)2.75130408
35Taurodontia (HP:0000679)2.75130408
36Abnormality of permanent molar morphology (HP:0011071)2.75130408
37Nail dystrophy (HP:0008404)2.71222231
38Round ear (HP:0100830)2.70165524
39EMG: myopathic abnormalities (HP:0003458)2.69877623
40Ridged nail (HP:0001807)2.67295900
41Muscle fiber splitting (HP:0003555)2.65165890
42Absent eyelashes (HP:0000561)2.62249580
43Sparse eyelashes (HP:0000653)2.61774094
44Thick nail (HP:0001805)2.60858137
45Neck muscle weakness (HP:0000467)2.59028391
46Hyporeflexia of lower limbs (HP:0002600)2.58768759
47Trismus (HP:0000211)2.55260906
48Abnormality of molar morphology (HP:0011070)2.54678365
49Abnormality of molar (HP:0011077)2.54678365
50Mildly elevated creatine phosphokinase (HP:0008180)2.54468657
51Hypotrichosis (HP:0001006)2.50419398
52Abnormality of the neuromuscular junction (HP:0003398)2.50297878
53Fatigable weakness (HP:0003473)2.50297878
54Progressive muscle weakness (HP:0003323)2.50213237
55Aplasia cutis congenita (HP:0001057)2.46204038
56Myoglobinuria (HP:0002913)2.41686601
57Lip pit (HP:0100267)2.39437887
58Rhabdomyolysis (HP:0003201)2.38368330
59Abnormality of the salivary glands (HP:0010286)2.37754245
60Abnormality of the calf musculature (HP:0001430)2.37714462
61Abnormality of the dental pulp (HP:0006479)2.36842569
62Advanced eruption of teeth (HP:0006288)2.33346071
63Calcaneovalgus deformity (HP:0001848)2.33301631
64Hip contracture (HP:0003273)2.32316708
65Difficulty climbing stairs (HP:0003551)2.31684010
66Calf muscle hypertrophy (HP:0008981)2.28727436
67Oral leukoplakia (HP:0002745)2.27448734
68Sparse scalp hair (HP:0002209)2.26374500
69Natal tooth (HP:0000695)2.24781057
70Fragile skin (HP:0001030)2.18056753
71Distal lower limb amyotrophy (HP:0008944)2.14242449
72Sudden death (HP:0001699)2.13347984
73Hypoplastic labia majora (HP:0000059)2.10232568
74Absent hair (HP:0002298)2.09195996
75Muscle stiffness (HP:0003552)2.04613070
76Abnormality of the labia majora (HP:0012881)2.04466694
77Abnormality of skeletal muscle fiber size (HP:0012084)2.04280848
78Congenital ichthyosiform erythroderma (HP:0007431)1.98590030
79Deformed tarsal bones (HP:0008119)1.96855680
80Hypoplasia of dental enamel (HP:0006297)1.96031146
81Palmoplantar keratoderma (HP:0000982)1.94308234
82Amelogenesis imperfecta (HP:0000705)1.92509438
83Subaortic stenosis (HP:0001682)1.90516244
84Abnormality of the left ventricular outflow tract (HP:0011103)1.90516244
85Corneal dystrophy (HP:0001131)1.88690304
86Abnormality of the lacrimal duct (HP:0011481)1.87488955
87Generalized muscle weakness (HP:0003324)1.84144085
88Abnormality of the calcaneus (HP:0008364)1.82521457
89Rimmed vacuoles (HP:0003805)1.80989832
90Limb-girdle muscle atrophy (HP:0003797)1.78091751
91Abnormal blistering of the skin (HP:0008066)1.77817848
92Limited hip movement (HP:0008800)1.77326387
93Corneal erosion (HP:0200020)1.75754243
94Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.75119080
95EMG: neuropathic changes (HP:0003445)1.72455618
96Dilated cardiomyopathy (HP:0001644)1.69647874
97Spinal rigidity (HP:0003306)1.67851807
98Facial cleft (HP:0002006)1.67697483
99Absent phalangeal crease (HP:0006109)1.66871466
100Bundle branch block (HP:0011710)1.65418401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.87653307
2OBSCN4.32816727
3LATS13.94623659
4NME13.88471556
5MST1R3.67112929
6TTN3.40916550
7MET2.81557996
8LATS22.78848177
9PHKG22.59980106
10PHKG12.59980106
11MAPKAPK32.40561477
12PBK2.34472042
13MST42.27949241
14STK38L2.03051932
15EPHB21.92271985
16EEF2K1.76292850
17PTK21.64006303
18NME21.62668219
19RPS6KB21.61421377
20STK161.52868736
21BUB11.49192636
22MAP3K91.43335179
23NTRK11.42000356
24MAPK151.40975501
25ARAF1.38196230
26PAK41.35757704
27FLT31.27019100
28TRPM71.26539307
29TTK1.23699234
30TESK11.17869847
31LIMK11.15929260
32MUSK1.14759981
33STK381.11714239
34SIK11.06859008
35MAP3K71.04779683
36TRIB31.02041606
37CDK121.01442300
38EPHB10.95832863
39SMG10.89727452
40BMX0.89443133
41PDGFRA0.85736704
42RIPK10.82082682
43STK240.81084290
44ABL20.78778865
45CAMK2G0.76228544
46MAP3K20.75067725
47MAP3K120.74666913
48MAP3K30.74543350
49MYLK0.72562957
50CDK190.71326998
51CDK70.70838093
52NEK10.68292571
53PIK3CG0.68252535
54PTK60.65620474
55MAP2K60.65199591
56MAP3K60.64609580
57TESK20.63109791
58DMPK0.62096752
59STK30.57268179
60VRK20.55932576
61ILK0.55367103
62AURKB0.54331070
63TGFBR10.52379300
64PLK40.49501965
65MAPK120.49265331
66MOS0.48748699
67RPS6KA40.47571994
68FER0.47264909
69MAP3K130.46755319
70FGFR10.46417955
71MTOR0.46116150
72MAP2K10.46059204
73PLK10.45797093
74PDGFRB0.44063627
75STK100.43418690
76NEK20.43205619
77PRKCI0.42787331
78AKT20.40390721
79CHEK20.38308120
80DAPK30.35420319
81AURKA0.34830039
82WEE10.31603730
83ERBB40.30065112
84CAMK2B0.29824822
85MAP2K40.28591374
86CDC42BPA0.27461970
87MAPKAPK50.27109746
88PRKAA20.26123715
89BRAF0.24491490
90WNK40.24188108
91LRRK20.23546555
92CAMK2D0.23354942
93SRPK10.23177599
94PRKD20.22725441
95PINK10.21709927
96MAP3K100.20007801
97MAP3K80.18906453
98CDK90.18310988
99TLK10.17769576
100MAPKAPK20.17350416

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030502.84400124
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.80917819
3Ribosome_Homo sapiens_hsa030102.71114740
4Cardiac muscle contraction_Homo sapiens_hsa042602.38335498
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.25909564
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.18275622
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.16027673
8Galactose metabolism_Homo sapiens_hsa000522.05933507
9Oxidative phosphorylation_Homo sapiens_hsa001902.02594218
10Basal cell carcinoma_Homo sapiens_hsa052171.96537761
11Dilated cardiomyopathy_Homo sapiens_hsa054141.89406680
12ECM-receptor interaction_Homo sapiens_hsa045121.80638358
13Parkinsons disease_Homo sapiens_hsa050121.75921513
14Biosynthesis of amino acids_Homo sapiens_hsa012301.66218723
15Fructose and mannose metabolism_Homo sapiens_hsa000511.61391458
16Mismatch repair_Homo sapiens_hsa034301.60351986
17Hippo signaling pathway_Homo sapiens_hsa043901.58814525
18Hedgehog signaling pathway_Homo sapiens_hsa043401.56472955
19Huntingtons disease_Homo sapiens_hsa050161.55394608
20Pentose phosphate pathway_Homo sapiens_hsa000301.54714602
21Tight junction_Homo sapiens_hsa045301.54112883
22Alzheimers disease_Homo sapiens_hsa050101.53551070
23Homologous recombination_Homo sapiens_hsa034401.51880199
24Sulfur relay system_Homo sapiens_hsa041221.45438616
25DNA replication_Homo sapiens_hsa030301.45381507
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.43173195
27Thyroid cancer_Homo sapiens_hsa052161.42267341
28Adherens junction_Homo sapiens_hsa045201.39930300
29Arginine biosynthesis_Homo sapiens_hsa002201.39360005
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39254392
31Arginine and proline metabolism_Homo sapiens_hsa003301.37431147
32Carbon metabolism_Homo sapiens_hsa012001.34120509
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28566792
34Pyruvate metabolism_Homo sapiens_hsa006201.26330190
35Base excision repair_Homo sapiens_hsa034101.21342170
36Nucleotide excision repair_Homo sapiens_hsa034201.16965937
37Phenylalanine metabolism_Homo sapiens_hsa003601.16673725
38Small cell lung cancer_Homo sapiens_hsa052221.15603255
39RNA polymerase_Homo sapiens_hsa030201.07429418
40Focal adhesion_Homo sapiens_hsa045101.06519012
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05959726
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05162002
43Insulin signaling pathway_Homo sapiens_hsa049101.01819602
44Fatty acid elongation_Homo sapiens_hsa000621.01776054
45Glutathione metabolism_Homo sapiens_hsa004800.99357368
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98515642
47Glucagon signaling pathway_Homo sapiens_hsa049220.97648446
48Central carbon metabolism in cancer_Homo sapiens_hsa052300.95091977
49RNA transport_Homo sapiens_hsa030130.91146350
50p53 signaling pathway_Homo sapiens_hsa041150.87050998
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86900091
52Wnt signaling pathway_Homo sapiens_hsa043100.83355422
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81679152
54Pyrimidine metabolism_Homo sapiens_hsa002400.80057113
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76980990
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75588454
57Proteoglycans in cancer_Homo sapiens_hsa052050.75202574
58Melanogenesis_Homo sapiens_hsa049160.73854621
59Circadian rhythm_Homo sapiens_hsa047100.73493778
60Fatty acid biosynthesis_Homo sapiens_hsa000610.71704879
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71164747
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70467428
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70247933
64Cell cycle_Homo sapiens_hsa041100.69859840
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.69267236
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69057943
67Axon guidance_Homo sapiens_hsa043600.68348653
68Bladder cancer_Homo sapiens_hsa052190.68039905
69Non-homologous end-joining_Homo sapiens_hsa034500.67989280
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64936985
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63591192
72Spliceosome_Homo sapiens_hsa030400.63330839
73Folate biosynthesis_Homo sapiens_hsa007900.62136763
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61463009
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61263268
76Tyrosine metabolism_Homo sapiens_hsa003500.59403241
77Pathways in cancer_Homo sapiens_hsa052000.58334648
78Metabolic pathways_Homo sapiens_hsa011000.57122842
79N-Glycan biosynthesis_Homo sapiens_hsa005100.55897300
80Histidine metabolism_Homo sapiens_hsa003400.55130205
81Starch and sucrose metabolism_Homo sapiens_hsa005000.54613999
82Notch signaling pathway_Homo sapiens_hsa043300.52415631
83Nitrogen metabolism_Homo sapiens_hsa009100.51943078
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50434602
85Fatty acid degradation_Homo sapiens_hsa000710.49921138
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49136611
87AMPK signaling pathway_Homo sapiens_hsa041520.48376663
88Amoebiasis_Homo sapiens_hsa051460.48331164
89Fatty acid metabolism_Homo sapiens_hsa012120.47664640
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46352355
91Vitamin digestion and absorption_Homo sapiens_hsa049770.44503719
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41120074
93Ovarian steroidogenesis_Homo sapiens_hsa049130.39943975
94beta-Alanine metabolism_Homo sapiens_hsa004100.39908342
95Fanconi anemia pathway_Homo sapiens_hsa034600.38212911
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36547917
97Linoleic acid metabolism_Homo sapiens_hsa005910.35826900
98Insulin resistance_Homo sapiens_hsa049310.35077231
99MicroRNAs in cancer_Homo sapiens_hsa052060.34693132
100Purine metabolism_Homo sapiens_hsa002300.34163402

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