NTHL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.64576669
2regulation of mitochondrial translation (GO:0070129)4.93780436
3proteasome assembly (GO:0043248)4.71382230
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.68967551
5ribosomal small subunit assembly (GO:0000028)4.62771449
6chaperone-mediated protein transport (GO:0072321)4.59803746
7DNA strand elongation involved in DNA replication (GO:0006271)4.52570543
8ribosomal small subunit biogenesis (GO:0042274)4.42358685
9formation of translation preinitiation complex (GO:0001731)4.37475448
10viral transcription (GO:0019083)4.32554421
11nucleobase biosynthetic process (GO:0046112)4.30426971
12translational termination (GO:0006415)4.28913447
13telomere maintenance via semi-conservative replication (GO:0032201)4.27595038
14DNA strand elongation (GO:0022616)4.26842003
15DNA replication initiation (GO:0006270)4.19107813
16purine nucleobase biosynthetic process (GO:0009113)4.14997465
17ATP synthesis coupled proton transport (GO:0015986)4.12923713
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.12923713
19maturation of SSU-rRNA (GO:0030490)4.05270851
20DNA unwinding involved in DNA replication (GO:0006268)3.92715238
21ribonucleoprotein complex biogenesis (GO:0022613)3.92018085
22ribosomal large subunit biogenesis (GO:0042273)3.87298525
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.85579223
24DNA replication checkpoint (GO:0000076)3.84578082
25L-serine metabolic process (GO:0006563)3.84297409
26translational elongation (GO:0006414)3.83763731
27ribosome biogenesis (GO:0042254)3.82454128
28pseudouridine synthesis (GO:0001522)3.82224373
29viral mRNA export from host cell nucleus (GO:0046784)3.80598508
30telomere maintenance via recombination (GO:0000722)3.72610085
31translational initiation (GO:0006413)3.71894623
32protein complex biogenesis (GO:0070271)3.63916504
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.61930578
34protein targeting to mitochondrion (GO:0006626)3.61752930
35rRNA modification (GO:0000154)3.60721634
36mitochondrial respiratory chain complex assembly (GO:0033108)3.60270704
37rRNA processing (GO:0006364)3.59843851
38pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.56751413
39cotranslational protein targeting to membrane (GO:0006613)3.56618922
40cullin deneddylation (GO:0010388)3.54689223
41protein targeting to ER (GO:0045047)3.54357709
42pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.51747816
43rRNA metabolic process (GO:0016072)3.46446475
44mitotic recombination (GO:0006312)3.44902105
45folic acid-containing compound biosynthetic process (GO:0009396)3.44896383
46spliceosomal snRNP assembly (GO:0000387)3.43899827
47mitotic metaphase plate congression (GO:0007080)3.42255694
48respiratory electron transport chain (GO:0022904)3.42177628
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.41993976
50telomere maintenance via telomere lengthening (GO:0010833)3.41535145
51protein maturation by protein folding (GO:0022417)3.40967102
52transcription-coupled nucleotide-excision repair (GO:0006283)3.40717317
53establishment of integrated proviral latency (GO:0075713)3.39185415
54establishment of protein localization to mitochondrion (GO:0072655)3.37732528
55CENP-A containing nucleosome assembly (GO:0034080)3.37554372
56somatic hypermutation of immunoglobulin genes (GO:0016446)3.36953017
57somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36953017
58mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.36658034
59protein localization to kinetochore (GO:0034501)3.36081548
60ribosome assembly (GO:0042255)3.36021216
61guanosine-containing compound biosynthetic process (GO:1901070)3.35794806
62oxidative phosphorylation (GO:0006119)3.35600122
63protein deneddylation (GO:0000338)3.35057677
64GTP biosynthetic process (GO:0006183)3.34672818
65UTP biosynthetic process (GO:0006228)3.34556542
66chromatin remodeling at centromere (GO:0031055)3.33961952
67protein localization to endoplasmic reticulum (GO:0070972)3.33561678
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33285598
69electron transport chain (GO:0022900)3.32730145
70establishment of protein localization to endoplasmic reticulum (GO:0072599)3.32602222
71pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.32359617
72CTP biosynthetic process (GO:0006241)3.32312464
73CTP metabolic process (GO:0046036)3.32312464
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.30800009
75mitochondrial respiratory chain complex I assembly (GO:0032981)3.30800009
76NADH dehydrogenase complex assembly (GO:0010257)3.30800009
77DNA replication-dependent nucleosome assembly (GO:0006335)3.30739509
78DNA replication-dependent nucleosome organization (GO:0034723)3.30739509
79* pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.30323988
80cellular protein complex disassembly (GO:0043624)3.29900713
81spliceosomal complex assembly (GO:0000245)3.29350327
82viral life cycle (GO:0019058)3.28417466
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.26243571
84nucleotide-excision repair, DNA gap filling (GO:0006297)3.26092673
85translation (GO:0006412)3.24740981
86establishment of viral latency (GO:0019043)3.23074153
87transcription from mitochondrial promoter (GO:0006390)3.22043487
88IMP biosynthetic process (GO:0006188)3.21521977
89protein localization to mitochondrion (GO:0070585)3.20731091
90IMP metabolic process (GO:0046040)3.20362269
91serine family amino acid biosynthetic process (GO:0009070)3.19798625
92positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.17827227
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16418144
94L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.16307236
95cellular component biogenesis (GO:0044085)3.15954554
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14052969
97pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.12368073
98regulation of cellular amino acid metabolic process (GO:0006521)3.11381471
99negative regulation of ligase activity (GO:0051352)3.11096781
100negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11096781
101transcription elongation from RNA polymerase III promoter (GO:0006385)3.10914652
102termination of RNA polymerase III transcription (GO:0006386)3.10914652
103folic acid metabolic process (GO:0046655)3.08341846
104kinetochore assembly (GO:0051382)3.07752868
105UTP metabolic process (GO:0046051)3.07268237
106mitochondrial RNA metabolic process (GO:0000959)3.05856560
107DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.05840254
108regulation of posttranscriptional gene silencing (GO:0060147)3.04487438
109regulation of gene silencing by miRNA (GO:0060964)3.04487438
110regulation of gene silencing by RNA (GO:0060966)3.04487438
111DNA damage response, detection of DNA damage (GO:0042769)3.03448226
112metaphase plate congression (GO:0051310)3.03067974
113positive regulation of ligase activity (GO:0051351)3.02532655
114cytochrome complex assembly (GO:0017004)3.01262489
115intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.00431197
116signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.00431197
117pteridine-containing compound biosynthetic process (GO:0042559)3.00399282
118exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99779980
119signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.99381384
120signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.99381384
121signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.99381384
122signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98363218
123signal transduction involved in DNA damage checkpoint (GO:0072422)2.98363218
124nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.96235516
125cell cycle G1/S phase transition (GO:0044843)2.94331721
126G1/S transition of mitotic cell cycle (GO:0000082)2.94331721
127deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93225503
128mitotic nuclear envelope disassembly (GO:0007077)2.93112807
129signal transduction involved in cell cycle checkpoint (GO:0072395)2.92871475
130protein complex disassembly (GO:0043241)2.91696557
131regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.89310836
132kinetochore organization (GO:0051383)2.89266914
133regulation of helicase activity (GO:0051095)2.88552268
134DNA replication-independent nucleosome organization (GO:0034724)2.87031153
135DNA replication-independent nucleosome assembly (GO:0006336)2.87031153
136proline biosynthetic process (GO:0006561)2.81606882
137rRNA methylation (GO:0031167)2.81593176
138nuclear-transcribed mRNA catabolic process (GO:0000956)2.81386335
139glycine metabolic process (GO:0006544)2.81303831

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.27856732
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.36111287
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.66629064
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.21864139
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.02757384
6MYC_18358816_ChIP-ChIP_MESCs_Mouse3.01438077
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97622450
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97132674
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93754419
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.86755485
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.85701105
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.81732580
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78085930
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67289351
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65882364
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60072749
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55198597
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34344501
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33217042
20XRN2_22483619_ChIP-Seq_HELA_Human2.30083436
21E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24788227
22AR_21909140_ChIP-Seq_LNCAP_Human2.24234925
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23316474
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.20070273
25DCP1A_22483619_ChIP-Seq_HELA_Human2.10545056
26VDR_23849224_ChIP-Seq_CD4+_Human1.98131812
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97138319
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94192788
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88913838
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86099634
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.83610070
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82371630
33* GABP_19822575_ChIP-Seq_HepG2_Human1.79848207
34* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79280495
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67682188
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.66525060
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.66525060
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.66525060
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65159556
40TTF2_22483619_ChIP-Seq_HELA_Human1.62364159
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61643209
42FOXP3_21729870_ChIP-Seq_TREG_Human1.61569563
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59598899
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56820503
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.54926749
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.54722619
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51520530
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.50397184
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48226475
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48163935
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46219394
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46105065
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.45697890
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41134399
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.40539219
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40086477
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38880535
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.37427290
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37168931
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35127282
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33368939
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32668023
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32074051
64NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.30772356
65ELK1_19687146_ChIP-ChIP_HELA_Human1.29099255
66SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27912506
67KDM5A_27292631_Chip-Seq_BREAST_Human1.25052154
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24572226
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23756853
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21931287
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20733806
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20713810
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20564614
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20543796
75SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19592749
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19505223
77* TFEB_21752829_ChIP-Seq_HELA_Human1.17607935
78CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16944096
79FOXP1_21924763_ChIP-Seq_HESCs_Human1.16502056
80CIITA_25753668_ChIP-Seq_RAJI_Human1.15251399
81ZNF263_19887448_ChIP-Seq_K562_Human1.12943851
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12533511
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12220748
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.11096725
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08685169
86* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08374363
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07956911
88* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07379017
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04950978
90NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.04893820
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04488415
92SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02173895
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02090154
94* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01115364
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00866721
96* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97444976
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96185046
98NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95687280
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95649650
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.95314703
101KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95123639
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93986808
103VDR_21846776_ChIP-Seq_THP-1_Human0.93774606
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93397162
105TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93272028
106CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92745153
107TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91263704
108MYC_18940864_ChIP-ChIP_HL60_Human0.89108650
109MYC_22102868_ChIP-Seq_BL_Human0.88988774
110SOX17_20123909_ChIP-Seq_XEN_Mouse0.88683009
111SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88208887
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88116643
113CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87931044
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85525129
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85085397
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83919601
117SOX2_18692474_ChIP-Seq_MESCs_Mouse0.83520260
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82287367

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.12576735
2MP0004957_abnormal_blastocyst_morpholog4.08951868
3MP0003806_abnormal_nucleotide_metabolis4.05404850
4MP0010094_abnormal_chromosome_stability3.65518304
5MP0003111_abnormal_nucleus_morphology3.55757031
6MP0008007_abnormal_cellular_replicative3.49054374
7MP0003077_abnormal_cell_cycle3.28712414
8MP0002254_reproductive_system_inflammat3.28449570
9MP0008057_abnormal_DNA_replication3.04333330
10MP0003786_premature_aging2.94408563
11* MP0008058_abnormal_DNA_repair2.64998464
12MP0003718_maternal_effect2.22001475
13MP0008932_abnormal_embryonic_tissue2.20468690
14MP0010030_abnormal_orbit_morphology2.10784866
15MP0003186_abnormal_redox_activity2.09204463
16MP0001730_embryonic_growth_arrest2.08113206
17MP0003011_delayed_dark_adaptation1.99657490
18MP0004233_abnormal_muscle_weight1.89106433
19MP0002396_abnormal_hematopoietic_system1.79938272
20MP0000350_abnormal_cell_proliferation1.77279235
21MP0009379_abnormal_foot_pigmentation1.75603762
22MP0004133_heterotaxia1.69504114
23MP0008789_abnormal_olfactory_epithelium1.66423565
24MP0009697_abnormal_copulation1.61231926
25MP0002132_abnormal_respiratory_system1.61044611
26MP0002736_abnormal_nociception_after1.50806085
27MP0000372_irregular_coat_pigmentation1.47697829
28MP0000049_abnormal_middle_ear1.46428126
29MP0002163_abnormal_gland_morphology1.40859187
30MP0005380_embryogenesis_phenotype1.38086868
31MP0001672_abnormal_embryogenesis/_devel1.38086868
32MP0001529_abnormal_vocalization1.34775253
33MP0002938_white_spotting1.33347358
34MP0002085_abnormal_embryonic_tissue1.33000061
35MP0008877_abnormal_DNA_methylation1.32260260
36MP0001697_abnormal_embryo_size1.31609838
37MP0001346_abnormal_lacrimal_gland1.30250697
38MP0002080_prenatal_lethality1.29381605
39MP0003121_genomic_imprinting1.29235037
40MP0005499_abnormal_olfactory_system1.28322999
41MP0005394_taste/olfaction_phenotype1.28322999
42MP0010352_gastrointestinal_tract_polyps1.27309415
43MP0003315_abnormal_perineum_morphology1.26355592
44MP0009672_abnormal_birth_weight1.24161396
45MP0000613_abnormal_salivary_gland1.22407573
46MP0001293_anophthalmia1.22158076
47MP0000490_abnormal_crypts_of1.20536147
48MP0001661_extended_life_span1.19276702
49MP0000313_abnormal_cell_death1.17042490
50MP0003984_embryonic_growth_retardation1.16731862
51MP0006292_abnormal_olfactory_placode1.16511412
52MP0003950_abnormal_plasma_membrane1.15756916
53MP0002088_abnormal_embryonic_growth/wei1.15270234
54MP0002084_abnormal_developmental_patter1.14913162
55MP0001545_abnormal_hematopoietic_system1.14784732
56MP0005397_hematopoietic_system_phenotyp1.14784732
57MP0002653_abnormal_ependyma_morphology1.12762964
58MP0001727_abnormal_embryo_implantation1.11046576
59MP0002160_abnormal_reproductive_system1.10798944
60MP0001188_hyperpigmentation1.09858819
61MP0009840_abnormal_foam_cell1.08632302
62MP0002086_abnormal_extraembryonic_tissu1.07751532
63MP0002249_abnormal_larynx_morphology1.07569271
64MP0003136_yellow_coat_color1.06403744
65MP0000537_abnormal_urethra_morphology1.05728700
66MP0002102_abnormal_ear_morphology1.05331100
67MP0003122_maternal_imprinting1.04476995
68MP0002019_abnormal_tumor_incidence1.03421900
69MP0003123_paternal_imprinting1.02758444
70* MP0005395_other_phenotype1.02135403
71MP0003941_abnormal_skin_development1.01615169
72MP0005389_reproductive_system_phenotype1.01436029
73MP0004185_abnormal_adipocyte_glucose1.01426514
74MP0005408_hypopigmentation1.01098548
75MP0003937_abnormal_limbs/digits/tail_de1.00495209
76MP0002697_abnormal_eye_size1.00200692
77MP0001905_abnormal_dopamine_level0.97718393
78MP0005670_abnormal_white_adipose0.96320841
79MP0006036_abnormal_mitochondrial_physio0.96318374
80MP0002111_abnormal_tail_morphology0.94517525
81MP0001764_abnormal_homeostasis0.91340355
82MP0005391_vision/eye_phenotype0.91224926
83MP0001986_abnormal_taste_sensitivity0.89970906
84MP0003705_abnormal_hypodermis_morpholog0.89885339
85MP0001145_abnormal_male_reproductive0.89755186
86MP0001849_ear_inflammation0.89266281
87MP0002092_abnormal_eye_morphology0.86559122
88MP0005266_abnormal_metabolism0.85838485
89MP0003567_abnormal_fetal_cardiomyocyte0.85819011
90MP0002210_abnormal_sex_determination0.85450046
91MP0003878_abnormal_ear_physiology0.83759951
92MP0005377_hearing/vestibular/ear_phenot0.83759951
93MP0004197_abnormal_fetal_growth/weight/0.82864673
94MP0005023_abnormal_wound_healing0.82631537
95MP0000762_abnormal_tongue_morphology0.82502750
96MP0004147_increased_porphyrin_level0.82291275
97MP0002127_abnormal_cardiovascular_syste0.81572514
98MP0003646_muscle_fatigue0.80943109
99MP0001286_abnormal_eye_development0.80607659
100MP0005253_abnormal_eye_physiology0.79492614
101MP0000653_abnormal_sex_gland0.79116454
102MP0009333_abnormal_splenocyte_physiolog0.78724960
103MP0002837_dystrophic_cardiac_calcinosis0.77933483
104MP0001968_abnormal_touch/_nociception0.77932239
105MP0010307_abnormal_tumor_latency0.75736964
106MP0000566_synostosis0.75343300
107MP0005085_abnormal_gallbladder_physiolo0.75107258
108MP0001119_abnormal_female_reproductive0.75102292
109MP0000477_abnormal_intestine_morphology0.74532355
110MP0006072_abnormal_retinal_apoptosis0.74156040
111MP0002796_impaired_skin_barrier0.73571144
112MP0000358_abnormal_cell_content/0.73338269
113MP0002233_abnormal_nose_morphology0.72926517
114MP0005075_abnormal_melanosome_morpholog0.71619517
115MP0000678_abnormal_parathyroid_gland0.71321218
116MP0005451_abnormal_body_composition0.69724035
117MP0005379_endocrine/exocrine_gland_phen0.68694460
118MP0003385_abnormal_body_wall0.68253732
119MP0003656_abnormal_erythrocyte_physiolo0.68177411
120MP0003119_abnormal_digestive_system0.67629069
121MP0002161_abnormal_fertility/fecundity0.67532481
122MP0008995_early_reproductive_senescence0.67103759
123MP0005646_abnormal_pituitary_gland0.66968641
124MP0005501_abnormal_skin_physiology0.66904007
125MP0003698_abnormal_male_reproductive0.66534889
126MP0001929_abnormal_gametogenesis0.66295551
127MP0002098_abnormal_vibrissa_morphology0.66216120
128MP0009053_abnormal_anal_canal0.65629491
129MP0005332_abnormal_amino_acid0.64494611
130MP0000750_abnormal_muscle_regeneration0.64283448
131MP0000689_abnormal_spleen_morphology0.63340756
132MP0001853_heart_inflammation0.62951839
133MP0000579_abnormal_nail_morphology0.60931354
134MP0004264_abnormal_extraembryonic_tissu0.60079861
135MP0001919_abnormal_reproductive_system0.59867076
136MP0003890_abnormal_embryonic-extraembry0.59398758
137MP0006035_abnormal_mitochondrial_morpho0.59247837
138MP0003936_abnormal_reproductive_system0.59173236

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.98907638
2Acute encephalopathy (HP:0006846)4.70540246
3Birth length less than 3rd percentile (HP:0003561)4.52034704
4Colon cancer (HP:0003003)3.96522398
5Breast hypoplasia (HP:0003187)3.87338971
6Progressive macrocephaly (HP:0004481)3.87227424
7Congenital stationary night blindness (HP:0007642)3.78369963
8Reticulocytopenia (HP:0001896)3.64431876
9Cerebral edema (HP:0002181)3.61846850
10Abnormality of cells of the erythroid lineage (HP:0012130)3.57771406
11Oral leukoplakia (HP:0002745)3.55983888
12Cerebral hypomyelination (HP:0006808)3.44212879
13Abnormal number of erythroid precursors (HP:0012131)3.29369756
14Microvesicular hepatic steatosis (HP:0001414)3.21494628
15Ependymoma (HP:0002888)3.13793832
16Lactic acidosis (HP:0003128)3.13541660
17Rough bone trabeculation (HP:0100670)3.02953696
18Macrocytic anemia (HP:0001972)3.02130957
19Hepatocellular necrosis (HP:0001404)3.00208117
20Selective tooth agenesis (HP:0001592)2.99248468
21Renal Fanconi syndrome (HP:0001994)2.98899541
22Increased muscle lipid content (HP:0009058)2.95071308
23Exercise intolerance (HP:0003546)2.93507138
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.85473000
25Hyperglycinemia (HP:0002154)2.84802432
26Testicular atrophy (HP:0000029)2.82207241
27Trismus (HP:0000211)2.82078221
28Multiple enchondromatosis (HP:0005701)2.81617815
29Hepatic necrosis (HP:0002605)2.78249592
30Respiratory failure (HP:0002878)2.64905044
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.64048066
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.64048066
33Rib fusion (HP:0000902)2.63100907
34Patellar aplasia (HP:0006443)2.61611901
35Microretrognathia (HP:0000308)2.58108646
3611 pairs of ribs (HP:0000878)2.55624054
37Agnosia (HP:0010524)2.54480732
38Absent radius (HP:0003974)2.54333585
39Increased serum pyruvate (HP:0003542)2.53870442
40Abnormality of glycolysis (HP:0004366)2.53870442
41Missing ribs (HP:0000921)2.52736290
42Hypobetalipoproteinemia (HP:0003563)2.50774314
43Respiratory difficulties (HP:0002880)2.47653314
44Aplasia/Hypoplasia of the patella (HP:0006498)2.45677994
45Leukodystrophy (HP:0002415)2.45259461
46Partial duplication of thumb phalanx (HP:0009944)2.37878916
47Premature ovarian failure (HP:0008209)2.37362393
48Aplastic anemia (HP:0001915)2.37131978
49Aplasia involving forearm bones (HP:0009822)2.34807793
50Absent forearm bone (HP:0003953)2.34807793
51Cleft eyelid (HP:0000625)2.34686619
52Premature graying of hair (HP:0002216)2.34141026
53Carpal bone hypoplasia (HP:0001498)2.34076078
54Increased serum lactate (HP:0002151)2.33054358
55Asplenia (HP:0001746)2.31650158
56Abnormal protein glycosylation (HP:0012346)2.29815957
57Abnormal glycosylation (HP:0012345)2.29815957
58Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29815957
59Abnormal protein N-linked glycosylation (HP:0012347)2.29815957
60Progressive muscle weakness (HP:0003323)2.28922948
61Medulloblastoma (HP:0002885)2.28577519
62Lethargy (HP:0001254)2.28141162
63Delayed CNS myelination (HP:0002188)2.26255160
64Pallor (HP:0000980)2.24252290
65Ragged-red muscle fibers (HP:0003200)2.23064074
66Horseshoe kidney (HP:0000085)2.22535736
67CNS hypomyelination (HP:0003429)2.18281928
68Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17448621
69Methylmalonic aciduria (HP:0012120)2.16916684
70Meckel diverticulum (HP:0002245)2.16535154
71Abnormal trabecular bone morphology (HP:0100671)2.15007950
72Rhabdomyosarcoma (HP:0002859)2.14418692
73Abnormal hemoglobin (HP:0011902)2.13158030
74Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.11920898
75Supernumerary spleens (HP:0009799)2.10345327
76Facial hemangioma (HP:0000329)2.09951279
77Stenosis of the external auditory canal (HP:0000402)2.09400974
78Abnormality of the ileum (HP:0001549)2.09127675
79Neoplasm of the oral cavity (HP:0100649)2.07928096
80Partial duplication of the phalanx of hand (HP:0009999)2.07826335
81Abnormality of the labia minora (HP:0012880)2.07729074
82Cutaneous melanoma (HP:0012056)2.07069817
83Megaloblastic anemia (HP:0001889)2.07007983
84Aplasia/Hypoplasia of the spleen (HP:0010451)2.06563441
85Sparse eyelashes (HP:0000653)2.06426355
86Abnormality of glycine metabolism (HP:0010895)2.05585346
87Abnormality of serine family amino acid metabolism (HP:0010894)2.05585346
88Abnormal lung lobation (HP:0002101)2.05051278
89Intrahepatic cholestasis (HP:0001406)2.04386924
90Broad distal phalanx of finger (HP:0009836)2.04330001
91Abnormal number of incisors (HP:0011064)2.03809172
92Secondary amenorrhea (HP:0000869)2.02616543
93Abnormality of serum amino acid levels (HP:0003112)2.01431743
94Abnormality of methionine metabolism (HP:0010901)2.01403399
95Emotional lability (HP:0000712)2.00394492
96Gout (HP:0001997)1.98585038
97Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97379136
98Dicarboxylic aciduria (HP:0003215)1.97379136
99Thrombocytosis (HP:0001894)1.96467633
100Optic disc pallor (HP:0000543)1.94782105
101Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94672081
102Abnormality of pyrimidine metabolism (HP:0004353)1.93197666
103CNS demyelination (HP:0007305)1.92743787
104Increased CSF lactate (HP:0002490)1.92428373
105Opisthotonus (HP:0002179)1.92223765
106Abnormality of abdominal situs (HP:0011620)1.91567554
107Abdominal situs inversus (HP:0003363)1.91567554
108Increased intramyocellular lipid droplets (HP:0012240)1.91514078
109Abnormality of the umbilical cord (HP:0010881)1.91435732
110Overlapping toe (HP:0001845)1.90938722
111Facial cleft (HP:0002006)1.90578724
112Abnormality of the heme biosynthetic pathway (HP:0010472)1.89504732
1133-Methylglutaconic aciduria (HP:0003535)1.89465825
114Increased hepatocellular lipid droplets (HP:0006565)1.89337039
115Aplasia/hypoplasia of the humerus (HP:0006507)1.89203455
116Mitochondrial inheritance (HP:0001427)1.88759976
117Atresia of the external auditory canal (HP:0000413)1.88283903
118Pancytopenia (HP:0001876)1.88232846
119Degeneration of anterior horn cells (HP:0002398)1.88054769
120Hyperglycinuria (HP:0003108)1.87208719
121Esophageal atresia (HP:0002032)1.86301654
122Abnormal mitochondria in muscle tissue (HP:0008316)1.84284901
123Rectovaginal fistula (HP:0000143)1.83928253
124Rectal fistula (HP:0100590)1.83928253
125Patent foramen ovale (HP:0001655)1.83694531
126Absent thumb (HP:0009777)1.82601023
127Reduced antithrombin III activity (HP:0001976)1.81695504
128Abnormality of the preputium (HP:0100587)1.80790064
129Duplicated collecting system (HP:0000081)1.80649482
130Sensory axonal neuropathy (HP:0003390)1.80250259
131Aplasia/Hypoplasia of the uvula (HP:0010293)1.80066486
132Neoplasm of the pancreas (HP:0002894)1.79783872
133Type I transferrin isoform profile (HP:0003642)1.79091663
134Chromsome breakage (HP:0040012)1.78798169
135Sex reversal (HP:0012245)1.77451189
136Abnormal sex determination (HP:0012244)1.77451189
137Abnormality of aromatic amino acid family metabolism (HP:0004338)1.77068074
138Duplication of thumb phalanx (HP:0009942)1.76758486
139Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75434704
140Basal cell carcinoma (HP:0002671)1.75120886
141Hypokinesia (HP:0002375)1.74977414
142Exertional dyspnea (HP:0002875)1.74651409
143Poor suck (HP:0002033)1.74447812
144Impulsivity (HP:0100710)1.74291249
145Squamous cell carcinoma (HP:0002860)1.74192611
146Lipid accumulation in hepatocytes (HP:0006561)1.74005345
147Abnormality of the anterior horn cell (HP:0006802)1.73963896
148Spastic paraparesis (HP:0002313)1.73400359
149Hypoplasia of the uterus (HP:0000013)1.72100605
150Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71614899
151Abnormality of alanine metabolism (HP:0010916)1.71614899
152Hyperalaninemia (HP:0003348)1.71614899
153Abnormality of renal resorption (HP:0011038)1.69371899
154Triphalangeal thumb (HP:0001199)1.69177463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.10724651
2BUB15.09908050
3WEE14.17937498
4EIF2AK13.07653028
5CDC72.73892937
6NME22.73638400
7PBK2.52069472
8TTK2.42173581
9BCKDK2.34492547
10TESK22.23780673
11CDK72.14683266
12TGFBR12.12749824
13RPS6KB22.01273620
14NEK22.01238486
15EPHA21.98652237
16SMG11.95142206
17PLK41.94234268
18TAF11.91120012
19EIF2AK31.89754376
20DYRK31.81286555
21PLK11.78664854
22NEK11.72103524
23VRK11.65276460
24PASK1.63499934
25CDK81.63272809
26TSSK61.61204909
27BRSK21.59802987
28TLK11.54391757
29STK161.53733689
30CDK191.51017674
31PIM21.46243246
32MAP3K81.43855716
33ARAF1.41729804
34CDK121.39518897
35AURKB1.35646657
36STK101.34324889
37SRPK11.34038291
38PAK41.33111567
39MST41.25977655
40AURKA1.22983673
41ATR1.22095858
42CCNB11.20172016
43CHEK21.17331652
44NUAK11.16423817
45MKNK11.13854444
46RPS6KA41.12896421
47STK391.10997926
48PDK21.10475094
49DAPK11.03062840
50NME11.00089451
51MAP3K110.96620271
52BRSK10.95287721
53STK40.93441209
54CSNK1A1L0.93284374
55CHEK10.92417047
56ZAK0.90588578
57CSNK1G20.88335477
58PLK30.87822206
59ICK0.86984125
60DAPK30.86761903
61TRIM280.86221583
62PAK10.82953110
63LRRK20.82149081
64CDK40.81387795
65ILK0.80922032
66SCYL20.80072139
67BMPR1B0.79246103
68MAP2K70.78481378
69ERN10.77850263
70PIM10.76755581
71RPS6KA50.75146198
72MAP2K20.71372464
73KDR0.70201300
74CSNK2A10.68395232
75CSNK2A20.66841482
76CDK20.65270958
77GRK60.61912699
78PRKCI0.61759190
79LATS20.59430600
80ABL20.54897297
81TESK10.53546032
82DYRK20.51718043
83MAP3K100.51641369
84ATM0.51514682
85FLT30.51133841
86MOS0.47516046
87MAPKAPK50.47264559
88MKNK20.46726106
89MAP4K10.46449561
90PRKD30.45367736
91CDK140.43829822
92CDK11A0.43759899
93MET0.43300522
94MAPK150.42528302
95ACVR1B0.42523246
96CDK10.42222004
97MAP2K30.40816868
98TYRO30.40083465
99MATK0.40009166
100ERBB40.39982267
101CLK10.37606442
102CDK60.37210656
103CDK150.36469052
104CSNK1G30.36341037
105AKT20.36214567
106CDK180.34407992
107EIF2AK20.34110880
108LIMK10.33448377
109PAK20.33195484
110MAPKAPK30.31369743
111IRAK30.29512907
112CSNK1E0.29334152
113CSNK1G10.29182090
114MAPK110.27293347
115BTK0.27032400
116CDK90.26877072
117MELK0.26761506
118PRKDC0.26184827
119TIE10.26132315
120BRAF0.25494781
121CSNK1A10.25402397
122MINK10.23518760
123WNK30.23381425
124CAMK2G0.23145807
125EEF2K0.22509306
126ALK0.22265533
127MAPK70.21699780
128PNCK0.20754655
129STK30.20616200

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.01824344
2Mismatch repair_Homo sapiens_hsa034303.82231603
3Ribosome_Homo sapiens_hsa030103.77515370
4Proteasome_Homo sapiens_hsa030503.34939174
5RNA polymerase_Homo sapiens_hsa030203.09843791
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.08862777
7Spliceosome_Homo sapiens_hsa030402.72958419
8Homologous recombination_Homo sapiens_hsa034402.52882169
9One carbon pool by folate_Homo sapiens_hsa006702.49472283
10* Base excision repair_Homo sapiens_hsa034102.41220972
11RNA transport_Homo sapiens_hsa030132.35250539
12Nucleotide excision repair_Homo sapiens_hsa034202.27528464
13Pyrimidine metabolism_Homo sapiens_hsa002402.16112296
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.83343839
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80194453
16Cell cycle_Homo sapiens_hsa041101.79123892
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.75296605
18Folate biosynthesis_Homo sapiens_hsa007901.69127635
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68630693
20Basal transcription factors_Homo sapiens_hsa030221.58441956
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.56065202
22RNA degradation_Homo sapiens_hsa030181.50325261
23Vitamin B6 metabolism_Homo sapiens_hsa007501.48193107
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.46537726
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.43722047
26Biosynthesis of amino acids_Homo sapiens_hsa012301.42073536
27Glutathione metabolism_Homo sapiens_hsa004801.40712241
28Fanconi anemia pathway_Homo sapiens_hsa034601.39933176
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.38970878
30Non-homologous end-joining_Homo sapiens_hsa034501.25668897
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21991904
32Steroid biosynthesis_Homo sapiens_hsa001001.18377426
33Fatty acid elongation_Homo sapiens_hsa000621.17754607
34Purine metabolism_Homo sapiens_hsa002301.17355449
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16747633
36Arginine and proline metabolism_Homo sapiens_hsa003301.15638800
37Phototransduction_Homo sapiens_hsa047441.14906304
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14594462
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14132905
40Sulfur relay system_Homo sapiens_hsa041221.13468210
41Pentose phosphate pathway_Homo sapiens_hsa000301.08879178
42Sulfur metabolism_Homo sapiens_hsa009201.06810638
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06133301
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03999839
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02943498
46Retinol metabolism_Homo sapiens_hsa008301.00409050
47Carbon metabolism_Homo sapiens_hsa012000.96888333
48p53 signaling pathway_Homo sapiens_hsa041150.94196144
49Cardiac muscle contraction_Homo sapiens_hsa042600.94159497
50Chemical carcinogenesis_Homo sapiens_hsa052040.93354773
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90734726
52Protein export_Homo sapiens_hsa030600.90382762
53mRNA surveillance pathway_Homo sapiens_hsa030150.86477868
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85805358
55Selenocompound metabolism_Homo sapiens_hsa004500.84181958
56Parkinsons disease_Homo sapiens_hsa050120.82589166
57Oxidative phosphorylation_Homo sapiens_hsa001900.81895059
58Fructose and mannose metabolism_Homo sapiens_hsa000510.78842380
59Huntingtons disease_Homo sapiens_hsa050160.78700304
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77886349
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77765573
62Propanoate metabolism_Homo sapiens_hsa006400.76361386
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72475206
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.70172683
65Systemic lupus erythematosus_Homo sapiens_hsa053220.69434206
66Epstein-Barr virus infection_Homo sapiens_hsa051690.66952872
67N-Glycan biosynthesis_Homo sapiens_hsa005100.65702730
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62290341
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.61353596
70Metabolic pathways_Homo sapiens_hsa011000.59524760
71Pyruvate metabolism_Homo sapiens_hsa006200.54167068
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53679225
73Peroxisome_Homo sapiens_hsa041460.53237040
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51631620
75Vitamin digestion and absorption_Homo sapiens_hsa049770.47320006
76Linoleic acid metabolism_Homo sapiens_hsa005910.47273604
77Galactose metabolism_Homo sapiens_hsa000520.45235623
78Arachidonic acid metabolism_Homo sapiens_hsa005900.44897774
79Arginine biosynthesis_Homo sapiens_hsa002200.44749923
80Nitrogen metabolism_Homo sapiens_hsa009100.44454252
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42308880
82Alcoholism_Homo sapiens_hsa050340.41287966
83Starch and sucrose metabolism_Homo sapiens_hsa005000.40094574
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38501603
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34329607
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33087343
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33006253
88Fatty acid metabolism_Homo sapiens_hsa012120.32723793
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32614820
90beta-Alanine metabolism_Homo sapiens_hsa004100.31293049
91Oocyte meiosis_Homo sapiens_hsa041140.31069172
92Phenylalanine metabolism_Homo sapiens_hsa003600.30086862
93Viral carcinogenesis_Homo sapiens_hsa052030.28445695
94Tryptophan metabolism_Homo sapiens_hsa003800.28424655
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27751962
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27227336
97Fat digestion and absorption_Homo sapiens_hsa049750.26729229
98Histidine metabolism_Homo sapiens_hsa003400.25907097
99Tyrosine metabolism_Homo sapiens_hsa003500.24896750
100Herpes simplex infection_Homo sapiens_hsa051680.24843261
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24733053
102Alzheimers disease_Homo sapiens_hsa050100.24451229
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23683556
104Basal cell carcinoma_Homo sapiens_hsa052170.23505865
105Hippo signaling pathway_Homo sapiens_hsa043900.21576197
106Fatty acid degradation_Homo sapiens_hsa000710.21522067
107Lysine degradation_Homo sapiens_hsa003100.18814072
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18586875
109Butanoate metabolism_Homo sapiens_hsa006500.16036905
110Hedgehog signaling pathway_Homo sapiens_hsa043400.15252964
111Vibrio cholerae infection_Homo sapiens_hsa051100.08904983
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.01688902
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.01337400

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