NTM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.74973662
2neuron cell-cell adhesion (GO:0007158)5.61980438
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.38683466
4ionotropic glutamate receptor signaling pathway (GO:0035235)5.21403140
5protein localization to synapse (GO:0035418)5.13789339
6glutamate receptor signaling pathway (GO:0007215)5.13212650
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.13166915
8regulation of short-term neuronal synaptic plasticity (GO:0048172)5.09462623
9synaptic vesicle exocytosis (GO:0016079)5.00901435
10regulation of glutamate receptor signaling pathway (GO:1900449)4.78740976
11neuronal action potential propagation (GO:0019227)4.70106346
12gamma-aminobutyric acid signaling pathway (GO:0007214)4.58796890
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.52562627
14presynaptic membrane assembly (GO:0097105)4.48119436
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.44854398
16locomotory exploration behavior (GO:0035641)4.43116292
17G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.41774341
18glutamate secretion (GO:0014047)4.40014845
19synaptic transmission, glutamatergic (GO:0035249)4.37648977
20neuron-neuron synaptic transmission (GO:0007270)4.30630837
21postsynaptic membrane organization (GO:0001941)4.23116290
22sodium ion export (GO:0071436)4.21230016
23regulation of synaptic vesicle exocytosis (GO:2000300)4.17509093
24negative regulation of synaptic transmission, GABAergic (GO:0032229)4.14736135
25presynaptic membrane organization (GO:0097090)4.12779421
26neurotransmitter-gated ion channel clustering (GO:0072578)4.09468786
27* neuron recognition (GO:0008038)4.00466148
28exploration behavior (GO:0035640)3.94164706
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.94026202
30gamma-aminobutyric acid transport (GO:0015812)3.88302827
31neurotransmitter secretion (GO:0007269)3.86874981
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.84083553
33layer formation in cerebral cortex (GO:0021819)3.83230188
34synaptic vesicle maturation (GO:0016188)3.81199619
35pyrimidine nucleobase catabolic process (GO:0006208)3.81110572
36dendritic spine morphogenesis (GO:0060997)3.80863112
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.79949342
38long-term memory (GO:0007616)3.76031852
39cell migration in hindbrain (GO:0021535)3.70763935
40regulation of postsynaptic membrane potential (GO:0060078)3.70237957
41regulation of synaptic vesicle transport (GO:1902803)3.70077921
42transmission of nerve impulse (GO:0019226)3.69063716
43response to histamine (GO:0034776)3.68106306
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67669112
45axonal fasciculation (GO:0007413)3.66716725
46positive regulation of synapse maturation (GO:0090129)3.60408270
47regulation of neuronal synaptic plasticity (GO:0048168)3.58502080
48positive regulation of synapse assembly (GO:0051965)3.55872410
49synaptic vesicle docking involved in exocytosis (GO:0016081)3.55265454
50regulation of synaptic transmission, glutamatergic (GO:0051966)3.54426291
51positive regulation of membrane potential (GO:0045838)3.51317108
52long-term synaptic potentiation (GO:0060291)3.47597512
53cellular potassium ion homeostasis (GO:0030007)3.47520072
54regulation of dendritic spine morphogenesis (GO:0061001)3.44872060
55axon ensheathment in central nervous system (GO:0032291)3.44481609
56central nervous system myelination (GO:0022010)3.44481609
57neurotransmitter transport (GO:0006836)3.43058901
58potassium ion import (GO:0010107)3.41730122
59cerebellar granule cell differentiation (GO:0021707)3.41470610
60regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.41242068
61central nervous system projection neuron axonogenesis (GO:0021952)3.40181455
62synaptic vesicle endocytosis (GO:0048488)3.38847071
63cerebellar Purkinje cell layer development (GO:0021680)3.38285995
64dendrite morphogenesis (GO:0048813)3.36536056
65regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.35697877
66membrane assembly (GO:0071709)3.33945168
67startle response (GO:0001964)3.31182780
68regulation of vesicle fusion (GO:0031338)3.29657470
69behavioral fear response (GO:0001662)3.28556094
70behavioral defense response (GO:0002209)3.28556094
71righting reflex (GO:0060013)3.28215649
72behavioral response to cocaine (GO:0048148)3.24375995
73fear response (GO:0042596)3.23687439
74regulation of synaptic plasticity (GO:0048167)3.22519153
75regulation of synapse structural plasticity (GO:0051823)3.21117199
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21057090
77synapse assembly (GO:0007416)3.20733365
78cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20116728
79potassium ion homeostasis (GO:0055075)3.19566525
80regulation of dendritic spine development (GO:0060998)3.19513669
81cerebellar Purkinje cell differentiation (GO:0021702)3.18666259
82positive regulation of dendritic spine development (GO:0060999)3.18502446
83proline transport (GO:0015824)3.17545988
84membrane depolarization (GO:0051899)3.17196425
85regulation of synapse maturation (GO:0090128)3.15362138
86L-amino acid import (GO:0043092)3.14229726
87regulation of neurotransmitter secretion (GO:0046928)3.13094004
88positive regulation of neurotransmitter secretion (GO:0001956)3.12230297
89membrane hyperpolarization (GO:0060081)3.12157408
90cellular sodium ion homeostasis (GO:0006883)3.11444837
91amino acid import (GO:0043090)3.11270019
92positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11088517
93positive regulation of dendritic spine morphogenesis (GO:0061003)3.10572712
94regulation of neurotransmitter levels (GO:0001505)3.08249278
95serotonin metabolic process (GO:0042428)3.07921414
96auditory behavior (GO:0031223)3.07796796
97nucleobase catabolic process (GO:0046113)3.05169043
98learning (GO:0007612)3.02704195
99regulation of glutamate secretion (GO:0014048)2.99556119
100cochlea development (GO:0090102)2.99427768
101regulation of synapse assembly (GO:0051963)2.99120054
102membrane depolarization during action potential (GO:0086010)2.97941681
103cell communication by electrical coupling (GO:0010644)2.97900676
104mechanosensory behavior (GO:0007638)2.95675114
105innervation (GO:0060384)2.95537965
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95485227
107synaptic transmission (GO:0007268)2.95121177
108positive regulation of neurotransmitter transport (GO:0051590)2.94631763
109neuromuscular synaptic transmission (GO:0007274)2.94300387
110regulation of respiratory system process (GO:0044065)2.94237044
111response to auditory stimulus (GO:0010996)2.91543171
112G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.91191791
113synapse organization (GO:0050808)2.90295311
114regulation of neurotransmitter transport (GO:0051588)2.88592796
115cerebral cortex radially oriented cell migration (GO:0021799)2.87183672
116detection of calcium ion (GO:0005513)2.86197650
117positive regulation of synaptic transmission, GABAergic (GO:0032230)2.85503097
118establishment of mitochondrion localization (GO:0051654)2.84688716
119regulation of synapse organization (GO:0050807)2.84605283
120adult walking behavior (GO:0007628)2.84438334
121regulation of synaptic transmission (GO:0050804)2.83411710
122response to gravity (GO:0009629)2.83244677
123neuronal ion channel clustering (GO:0045161)2.82987742
124C4-dicarboxylate transport (GO:0015740)2.81042390
125social behavior (GO:0035176)2.80174471
126intraspecies interaction between organisms (GO:0051703)2.80174471
127positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.77806083
128positive regulation of potassium ion transmembrane transport (GO:1901381)2.76431814
129neurotransmitter uptake (GO:0001504)2.74189812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.05657695
2GBX2_23144817_ChIP-Seq_PC3_Human4.16287435
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.20197997
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13520043
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05201968
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.67877271
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67246458
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66690978
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66690978
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60433447
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60165680
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53412289
13TAF15_26573619_Chip-Seq_HEK293_Human2.48496671
14* EED_16625203_ChIP-ChIP_MESCs_Mouse2.48022711
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.47033708
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37640435
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30421616
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19203084
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.14081414
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13420810
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.13345820
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12332174
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09321216
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07394247
25AR_21572438_ChIP-Seq_LNCaP_Human2.05297852
26DROSHA_22980978_ChIP-Seq_HELA_Human1.98875828
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92502205
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92006506
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.88360352
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.87676949
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78875625
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77535449
33SMAD4_21799915_ChIP-Seq_A2780_Human1.77003416
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76278549
35* CBX2_27304074_Chip-Seq_ESCs_Mouse1.75992243
36* P300_19829295_ChIP-Seq_ESCs_Human1.75473617
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75058673
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73019321
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.70262802
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69687318
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66320896
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60141122
43VDR_22108803_ChIP-Seq_LS180_Human1.58890441
44FUS_26573619_Chip-Seq_HEK293_Human1.58480525
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51136794
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49510486
47* SMAD3_21741376_ChIP-Seq_EPCs_Human1.47791013
48ZNF274_21170338_ChIP-Seq_K562_Hela1.47044946
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.45522741
50IGF1R_20145208_ChIP-Seq_DFB_Human1.45354912
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43713138
52* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43278053
53* RNF2_27304074_Chip-Seq_NSC_Mouse1.39966368
54* AR_25329375_ChIP-Seq_VCAP_Human1.36873542
55* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35079584
56* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31307686
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27995623
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.27685643
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27161433
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.25785793
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.25701488
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.24680662
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23455537
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22290267
65* STAT3_23295773_ChIP-Seq_U87_Human1.22039323
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21580427
67* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18809686
68ER_23166858_ChIP-Seq_MCF-7_Human1.16522687
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16171884
70TCF4_23295773_ChIP-Seq_U87_Human1.13798149
71RUNX2_22187159_ChIP-Seq_PCA_Human1.13588495
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13520201
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.13322278
74* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12660720
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12600375
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12124147
77* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11925365
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.11630765
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10959752
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10377699
81AR_19668381_ChIP-Seq_PC3_Human1.09708092
82SOX9_26525672_Chip-Seq_HEART_Mouse1.09565281
83* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09291790
84TP53_18474530_ChIP-ChIP_U2OS_Human1.08915290
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.08335227
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.07941660
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07578047
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07460082
89STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07405982
90TP53_16413492_ChIP-PET_HCT116_Human1.07262882
91* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04642052
92* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04642052
93* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04520776
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04414779
95BCAT_22108803_ChIP-Seq_LS180_Human1.04245151
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.03941469
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03921935
98* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03500380
99AHR_22903824_ChIP-Seq_MCF-7_Human1.03017896
100JUN_21703547_ChIP-Seq_K562_Human1.01494775
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.01144480
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00703995
103ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00153925
104* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97346030
105YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96583242
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96378063
107E2F1_18555785_Chip-Seq_ESCs_Mouse0.95239491
108KDM2B_26808549_Chip-Seq_REH_Human0.93316178
109RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91344168
110P53_22387025_ChIP-Seq_ESCs_Mouse0.89314456
111CMYC_18555785_Chip-Seq_ESCs_Mouse0.88992657
112BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88072444
113CBP_20019798_ChIP-Seq_JUKART_Human0.87192525
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87192525

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.49179056
2MP0004859_abnormal_synaptic_plasticity5.26978388
3MP0003635_abnormal_synaptic_transmissio3.96331909
4MP0009745_abnormal_behavioral_response3.42445424
5MP0004270_analgesia3.25467724
6MP0002063_abnormal_learning/memory/cond3.19791873
7MP0009046_muscle_twitch3.17234357
8MP0001968_abnormal_touch/_nociception3.16478420
9MP0002064_seizures3.09143085
10MP0002572_abnormal_emotion/affect_behav2.87602566
11MP0005423_abnormal_somatic_nervous2.73102245
12MP0001486_abnormal_startle_reflex2.71796665
13MP0002272_abnormal_nervous_system2.70044012
14MP0002736_abnormal_nociception_after2.64222955
15MP0002734_abnormal_mechanical_nocicepti2.47929378
16MP0001501_abnormal_sleep_pattern2.46438011
17MP0001440_abnormal_grooming_behavior2.43316956
18MP0002735_abnormal_chemical_nociception2.24341497
19MP0002067_abnormal_sensory_capabilities2.19474402
20MP0006276_abnormal_autonomic_nervous2.00743355
21MP0000778_abnormal_nervous_system1.97739558
22MP0002184_abnormal_innervation1.91913224
23MP0002733_abnormal_thermal_nociception1.90362125
24MP0001970_abnormal_pain_threshold1.86479850
25MP0002557_abnormal_social/conspecific_i1.86464538
26MP0001188_hyperpigmentation1.85816917
27MP0001984_abnormal_olfaction1.77764770
28MP0001529_abnormal_vocalization1.77466588
29MP0000569_abnormal_digit_pigmentation1.76034410
30MP0003329_amyloid_beta_deposits1.75652671
31MP0005386_behavior/neurological_phenoty1.69329816
32MP0004924_abnormal_behavior1.69329816
33MP0005646_abnormal_pituitary_gland1.63968744
34MP0005551_abnormal_eye_electrophysiolog1.61108106
35MP0008569_lethality_at_weaning1.59541310
36MP0009780_abnormal_chondrocyte_physiolo1.51850881
37MP0003879_abnormal_hair_cell1.48527788
38MP0002822_catalepsy1.47921789
39MP0004142_abnormal_muscle_tone1.47433837
40MP0001502_abnormal_circadian_rhythm1.42893644
41MP0002882_abnormal_neuron_morphology1.40983432
42MP0000955_abnormal_spinal_cord1.40797873
43MP0001299_abnormal_eye_distance/1.40682956
44MP0001905_abnormal_dopamine_level1.38268902
45MP0004742_abnormal_vestibular_system1.38034582
46MP0002066_abnormal_motor_capabilities/c1.37664282
47MP0004811_abnormal_neuron_physiology1.34843056
48MP0005645_abnormal_hypothalamus_physiol1.31781323
49MP0003787_abnormal_imprinting1.31330450
50MP0004145_abnormal_muscle_electrophysio1.31017168
51MP0005409_darkened_coat_color1.28089540
52MP0004885_abnormal_endolymph1.26948447
53MP0004858_abnormal_nervous_system1.22977444
54MP0006292_abnormal_olfactory_placode1.21829097
55MP0002837_dystrophic_cardiac_calcinosis1.21481428
56MP0003283_abnormal_digestive_organ1.15404887
57MP0006072_abnormal_retinal_apoptosis1.14349749
58MP0003633_abnormal_nervous_system1.12828478
59MP0002152_abnormal_brain_morphology1.11008112
60MP0002909_abnormal_adrenal_gland1.10235263
61MP0001963_abnormal_hearing_physiology1.09929473
62MP0005623_abnormal_meninges_morphology1.04943802
63MP0003122_maternal_imprinting1.04866215
64MP0002229_neurodegeneration1.02893975
65MP0000631_abnormal_neuroendocrine_gland1.01875666
66MP0010386_abnormal_urinary_bladder1.00698971
67MP0003631_nervous_system_phenotype0.99940077
68MP0000751_myopathy0.99642920
69MP0000566_synostosis0.98920400
70MP0002752_abnormal_somatic_nervous0.97704331
71MP0002234_abnormal_pharynx_morphology0.97469811
72MP0002876_abnormal_thyroid_physiology0.95707991
73MP0005503_abnormal_tendon_morphology0.93851708
74MP0002638_abnormal_pupillary_reflex0.93624052
75MP0001485_abnormal_pinna_reflex0.91051463
76MP0004215_abnormal_myocardial_fiber0.89849024
77MP0008872_abnormal_physiological_respon0.89288055
78MP0000026_abnormal_inner_ear0.88633844
79MP0002102_abnormal_ear_morphology0.87612702
80MP0000534_abnormal_ureter_morphology0.87356860
81MP0001986_abnormal_taste_sensitivity0.86912194
82MP0005394_taste/olfaction_phenotype0.86538340
83MP0005499_abnormal_olfactory_system0.86538340
84MP0008438_abnormal_cutaneous_collagen0.86333196
85MP0004133_heterotaxia0.86278799
86MP0002069_abnormal_eating/drinking_beha0.85919391
87MP0004085_abnormal_heartbeat0.84743301
88MP0002751_abnormal_autonomic_nervous0.84083865
89MP0004484_altered_response_of0.83293343
90MP0003121_genomic_imprinting0.82494940
91MP0005535_abnormal_body_temperature0.82247786
92MP0001958_emphysema0.81605138
93MP0005253_abnormal_eye_physiology0.79889122
94MP0003634_abnormal_glial_cell0.79387598
95MP0001664_abnormal_digestion0.78263010
96MP0002090_abnormal_vision0.77652726
97MP0000462_abnormal_digestive_system0.74845700
98MP0008874_decreased_physiological_sensi0.74376801
99MP0009250_abnormal_appendicular_skeleto0.73957873
100MP0003632_abnormal_nervous_system0.73331657
101MP0003137_abnormal_impulse_conducting0.73185729
102MP0000604_amyloidosis0.70199612
103MP0003136_yellow_coat_color0.70029296
104MP0003938_abnormal_ear_development0.69796110
105MP0005595_abnormal_vascular_smooth0.68552842
106MP0009379_abnormal_foot_pigmentation0.65829389
107MP0003690_abnormal_glial_cell0.65813159
108MP0003119_abnormal_digestive_system0.64880252
109MP0000579_abnormal_nail_morphology0.63661324
110MP0000920_abnormal_myelination0.63363905
111MP0003385_abnormal_body_wall0.63260035
112MP0004233_abnormal_muscle_weight0.62635343
113MP0000049_abnormal_middle_ear0.62094219
114MP0010770_preweaning_lethality0.61771447
115MP0002082_postnatal_lethality0.61771447
116MP0002081_perinatal_lethality0.61115168
117MP0010769_abnormal_survival0.61050724
118MP0005195_abnormal_posterior_eye0.60776363
119MP0001943_abnormal_respiration0.58960867
120MP0003861_abnormal_nervous_system0.58683056
121MP0000013_abnormal_adipose_tissue0.57764202
122MP0001177_atelectasis0.57510946
123MP0005187_abnormal_penis_morphology0.55227484
124MP0005171_absent_coat_pigmentation0.54083524
125MP0005379_endocrine/exocrine_gland_phen0.53686361

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.07856484
2Focal seizures (HP:0007359)5.66851710
3Atonic seizures (HP:0010819)5.48691983
4Epileptic encephalopathy (HP:0200134)5.46392172
5Myokymia (HP:0002411)4.90482671
6Visual hallucinations (HP:0002367)4.87210539
7Febrile seizures (HP:0002373)4.82207809
8Absence seizures (HP:0002121)4.64391673
9Hyperventilation (HP:0002883)4.60181128
10Progressive cerebellar ataxia (HP:0002073)4.41515864
11Dialeptic seizures (HP:0011146)4.16370561
12Generalized tonic-clonic seizures (HP:0002069)4.09727908
13Broad-based gait (HP:0002136)4.04129974
14Hemiparesis (HP:0001269)3.33892636
15Abnormality of binocular vision (HP:0011514)3.29973012
16Diplopia (HP:0000651)3.29973012
17Gaze-evoked nystagmus (HP:0000640)3.22586857
18Excessive salivation (HP:0003781)3.16651438
19Drooling (HP:0002307)3.16651438
20Dysdiadochokinesis (HP:0002075)3.16255358
21Amblyopia (HP:0000646)3.14118802
22Poor eye contact (HP:0000817)3.03701147
23Torticollis (HP:0000473)3.02707360
24Action tremor (HP:0002345)3.00217860
25Cerebral inclusion bodies (HP:0100314)2.92798151
26Truncal ataxia (HP:0002078)2.89609748
27Supranuclear gaze palsy (HP:0000605)2.87982765
28Dynein arm defect of respiratory motile cilia (HP:0012255)2.78487402
29Absent/shortened dynein arms (HP:0200106)2.78487402
30Absent speech (HP:0001344)2.77261839
31Neurofibrillary tangles (HP:0002185)2.74796100
32Dysmetria (HP:0001310)2.73873636
33Anxiety (HP:0000739)2.72101114
34Epileptiform EEG discharges (HP:0011182)2.66527735
35Impaired social interactions (HP:0000735)2.65799921
36Abnormal social behavior (HP:0012433)2.65799921
37Akinesia (HP:0002304)2.65108779
38Abnormal eating behavior (HP:0100738)2.62152078
39Progressive inability to walk (HP:0002505)2.61477956
40Inability to walk (HP:0002540)2.59662000
41Gait imbalance (HP:0002141)2.56661510
42Impaired vibration sensation in the lower limbs (HP:0002166)2.56365774
43Ulnar claw (HP:0001178)2.55169164
44Status epilepticus (HP:0002133)2.52749354
45EEG with generalized epileptiform discharges (HP:0011198)2.48330144
46Sleep apnea (HP:0010535)2.44417773
47Protruding tongue (HP:0010808)2.41374064
48Genetic anticipation (HP:0003743)2.39300372
49Polyphagia (HP:0002591)2.38579022
50Depression (HP:0000716)2.38420410
51Focal dystonia (HP:0004373)2.37789105
52Mutism (HP:0002300)2.37205538
53Urinary bladder sphincter dysfunction (HP:0002839)2.36568554
54Scanning speech (HP:0002168)2.34843841
55Hemiplegia (HP:0002301)2.32261136
56Impaired smooth pursuit (HP:0007772)2.30450194
57Peripheral hypomyelination (HP:0007182)2.28559574
58Generalized myoclonic seizures (HP:0002123)2.24864185
59Abnormal ciliary motility (HP:0012262)2.22851667
60Hypsarrhythmia (HP:0002521)2.22628204
61Broad metatarsal (HP:0001783)2.20688123
62Abnormality of salivation (HP:0100755)2.20168890
63Abnormality of the corticospinal tract (HP:0002492)2.20101947
64Megalencephaly (HP:0001355)2.18550986
65Medial flaring of the eyebrow (HP:0010747)2.16947121
66Insidious onset (HP:0003587)2.16371350
67Termporal pattern (HP:0011008)2.16371350
68Craniofacial dystonia (HP:0012179)2.16195094
69Stereotypic behavior (HP:0000733)2.14128807
70Congenital primary aphakia (HP:0007707)2.13825958
71Intention tremor (HP:0002080)2.13689315
72Retinal dysplasia (HP:0007973)2.07393534
73Obstructive sleep apnea (HP:0002870)2.05834028
74Fetal akinesia sequence (HP:0001989)2.04091894
75Limb dystonia (HP:0002451)2.02599202
76Spastic gait (HP:0002064)2.01582152
77Abnormality of the lower motor neuron (HP:0002366)2.01294853
78Ankle clonus (HP:0011448)1.99237944
79Delusions (HP:0000746)1.97149087
80Abnormality of ocular smooth pursuit (HP:0000617)1.96964648
81Agitation (HP:0000713)1.96903266
82Poor suck (HP:0002033)1.96503585
83Blue irides (HP:0000635)1.95904801
84Nephrogenic diabetes insipidus (HP:0009806)1.95133312
85Acute necrotizing encephalopathy (HP:0006965)1.91049755
86Psychosis (HP:0000709)1.89630245
87Postural instability (HP:0002172)1.88993414
88Urinary urgency (HP:0000012)1.88686388
89Morphological abnormality of the pyramidal tract (HP:0002062)1.88427206
90Hyperthyroidism (HP:0000836)1.88051015
91Bradykinesia (HP:0002067)1.87629952
92Abnormal respiratory motile cilium morphology (HP:0005938)1.87556518
93Abnormal respiratory epithelium morphology (HP:0012253)1.87556518
94Specific learning disability (HP:0001328)1.87518378
95Esotropia (HP:0000565)1.86852481
96Fair hair (HP:0002286)1.86631394
97Abnormal respiratory motile cilium physiology (HP:0012261)1.86479762
98Split foot (HP:0001839)1.86378866
99Progressive macrocephaly (HP:0004481)1.83590032
100Decreased muscle mass (HP:0003199)1.83515213
101Widely spaced teeth (HP:0000687)1.82501926
102Narrow nasal bridge (HP:0000446)1.82450972
103Shallow orbits (HP:0000586)1.82187477
104Degeneration of the lateral corticospinal tracts (HP:0002314)1.81909628
105Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81909628
106Clumsiness (HP:0002312)1.78208530
107Genital tract atresia (HP:0001827)1.77255982
108Gastroesophageal reflux (HP:0002020)1.76784289
109Hammertoe (HP:0001765)1.76733024
110Exotropia (HP:0000577)1.75833362
111Gait ataxia (HP:0002066)1.75667307
112Thickened helices (HP:0000391)1.75393872
113Annular pancreas (HP:0001734)1.75231045
114Dysmetric saccades (HP:0000641)1.74516942
115Hypoventilation (HP:0002791)1.74320107
116Vaginal atresia (HP:0000148)1.73594903
117Impaired vibratory sensation (HP:0002495)1.72963133
118Optic disc pallor (HP:0000543)1.72828115
119Aplasia involving bones of the upper limbs (HP:0009823)1.72386358
120Aplasia of the phalanges of the hand (HP:0009802)1.72386358
121Aplasia involving bones of the extremities (HP:0009825)1.72386358
122Spastic tetraplegia (HP:0002510)1.71413154
123Lower limb muscle weakness (HP:0007340)1.70995912
124Incomplete penetrance (HP:0003829)1.70647231
125Neonatal short-limb short stature (HP:0008921)1.67392824
126Cortical dysplasia (HP:0002539)1.66468481
127Mild short stature (HP:0003502)1.61593675
128Atrophic scars (HP:0001075)1.59077172
129Abnormality of the ischium (HP:0003174)1.56946126
130Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.56309733
131Arterial tortuosity (HP:0005116)1.54246896
132Palpebral edema (HP:0100540)1.53854872
133Prominent supraorbital ridges (HP:0000336)1.53759687
134Anterior segment dysgenesis (HP:0007700)1.53586621
135Prolonged QT interval (HP:0001657)1.52571962
136Overgrowth (HP:0001548)1.52489943
137Lower limb asymmetry (HP:0100559)1.51494850
138Vascular tortuosity (HP:0004948)1.50857303
139Pheochromocytoma (HP:0002666)1.50554125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.45402799
2NTRK34.17690948
3CASK4.01810073
4MAP3K43.15066293
5MARK13.02827995
6MAP2K72.87797634
7RIPK42.82573583
8MAP3K92.58802677
9PNCK2.43264837
10MAP3K122.32573056
11MINK12.29385528
12NTRK22.21086815
13TNIK2.06135682
14SIK22.01465450
15PLK21.96395035
16DAPK21.94120310
17MAP2K41.86820372
18MAPK131.72814350
19PAK61.65451313
20GRK51.52302398
21FES1.43065161
22BMPR21.39156323
23DAPK11.38983644
24CDK191.37744129
25CDK51.35317011
26PRKCG1.30438391
27DYRK21.29882644
28KSR11.29301705
29NME11.27389219
30TRIM281.25629480
31CAMK2A1.24855532
32LIMK11.20831001
33NTRK11.19472342
34FGR1.13473203
35OXSR11.10596478
36PRPF4B1.09029747
37ARAF1.05447582
38CAMK2B1.04898207
39KSR21.04270158
40PHKG11.03268379
41PHKG21.03268379
42DYRK1A0.99462690
43CAMKK20.99439799
44EPHB20.98491987
45PTK2B0.98084463
46MAP3K130.96934102
47UHMK10.95276105
48CAMKK10.93128650
49STK380.89785139
50PDGFRA0.86158891
51DDR20.85499258
52MUSK0.83852845
53PRKCE0.78741026
54CCNB10.77315940
55FGFR20.76210108
56CAMK10.75679938
57PAK30.73680728
58CDK180.73535840
59ROCK10.73163497
60CDK140.71218234
61CDK150.70523775
62FRK0.69506945
63GRK70.69154030
64SGK10.68874506
65CSNK1G30.66707274
66SGK4940.66491222
67SGK2230.66491222
68MAP4K20.65955105
69STK110.65485916
70CSNK1G20.65180278
71MAP3K60.64993333
72CAMK2D0.64519000
73CAMK1G0.64442208
74TNK20.63846457
75SIK30.63824570
76CDK11A0.61786599
77PKN10.60086767
78CSNK1G10.59918311
79CSNK1A1L0.59429294
80MAPKAPK50.57950780
81RPS6KA40.57297918
82MAPK120.57233211
83RAF10.57113312
84TYRO30.56837169
85SGK20.55766166
86MARK20.54519265
87PRKD30.54249063
88ADRBK20.53407883
89ROCK20.53053735
90MKNK20.52809754
91LATS20.52205278
92FER0.51490308
93CAMK2G0.51334708
94NEK60.50804096
95BCR0.50655189
96WNK30.50606085
97AKT30.49751511
98ADRBK10.49745155
99PRKCZ0.47206684
100PRKCH0.45913102
101PRKG20.45629946
102PRKACA0.44267154
103CDK30.44158964
104FYN0.43969099
105ERBB30.43753185
106MAPK150.43486995
107PRKG10.41476217
108RET0.40664297
109GRK60.40515039
110RPS6KA30.39606133
111PDGFRB0.39516020
112WNK10.38770794
113MAPK100.37016203
114INSRR0.35889641
115CSNK1A10.35715709
116PRKCB0.34658857
117STK390.34442995
118PRKCA0.34435264
119SGK30.34208180
120PDPK10.33901838
121CAMK40.33849476
122PAK20.32898423
123CSNK1D0.30998281
124PINK10.30762647
125CDC42BPA0.30597341

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.73847915
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.09664864
3Synaptic vesicle cycle_Homo sapiens_hsa047213.00911530
4GABAergic synapse_Homo sapiens_hsa047272.83362682
5Glutamatergic synapse_Homo sapiens_hsa047242.83297155
6Long-term potentiation_Homo sapiens_hsa047202.69356519
7Morphine addiction_Homo sapiens_hsa050322.67496085
8Circadian entrainment_Homo sapiens_hsa047132.64806871
9Amphetamine addiction_Homo sapiens_hsa050312.42917115
10Salivary secretion_Homo sapiens_hsa049702.32715173
11Taste transduction_Homo sapiens_hsa047422.32194251
12Olfactory transduction_Homo sapiens_hsa047402.28181730
13Dopaminergic synapse_Homo sapiens_hsa047282.10545803
14Collecting duct acid secretion_Homo sapiens_hsa049662.04136561
15Long-term depression_Homo sapiens_hsa047301.95565200
16Serotonergic synapse_Homo sapiens_hsa047261.95128028
17Renin secretion_Homo sapiens_hsa049241.91700052
18Insulin secretion_Homo sapiens_hsa049111.85615999
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84022474
20Phototransduction_Homo sapiens_hsa047441.82909748
21Gastric acid secretion_Homo sapiens_hsa049711.81040902
22Calcium signaling pathway_Homo sapiens_hsa040201.77985829
23Cholinergic synapse_Homo sapiens_hsa047251.66725591
24Oxytocin signaling pathway_Homo sapiens_hsa049211.62908041
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61696047
26Oxidative phosphorylation_Homo sapiens_hsa001901.54597949
27Cocaine addiction_Homo sapiens_hsa050301.53303138
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52998612
29Cardiac muscle contraction_Homo sapiens_hsa042601.49856604
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49478213
31Alzheimers disease_Homo sapiens_hsa050101.34064114
32Gap junction_Homo sapiens_hsa045401.28869903
33GnRH signaling pathway_Homo sapiens_hsa049121.24698542
34cAMP signaling pathway_Homo sapiens_hsa040241.22084711
35Axon guidance_Homo sapiens_hsa043601.21383772
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16190750
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09753755
38Vibrio cholerae infection_Homo sapiens_hsa051101.09361705
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06014747
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05687014
41Parkinsons disease_Homo sapiens_hsa050121.03015379
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97228608
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97124125
44Estrogen signaling pathway_Homo sapiens_hsa049150.96294937
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95464559
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95217478
47Melanogenesis_Homo sapiens_hsa049160.94925111
48Pancreatic secretion_Homo sapiens_hsa049720.94629415
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.93893642
50Vitamin B6 metabolism_Homo sapiens_hsa007500.91548479
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91049906
52ECM-receptor interaction_Homo sapiens_hsa045120.84120246
53Type II diabetes mellitus_Homo sapiens_hsa049300.79906669
54ErbB signaling pathway_Homo sapiens_hsa040120.77438159
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77067910
56Huntingtons disease_Homo sapiens_hsa050160.76691723
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75798750
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75122742
59Dilated cardiomyopathy_Homo sapiens_hsa054140.72894049
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72531787
61Hippo signaling pathway_Homo sapiens_hsa043900.71374938
62Glioma_Homo sapiens_hsa052140.68888329
63Thyroid hormone synthesis_Homo sapiens_hsa049180.66594652
64Dorso-ventral axis formation_Homo sapiens_hsa043200.63453663
65African trypanosomiasis_Homo sapiens_hsa051430.63071441
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.62783852
67MAPK signaling pathway_Homo sapiens_hsa040100.62659270
68Choline metabolism in cancer_Homo sapiens_hsa052310.62192205
69Oocyte meiosis_Homo sapiens_hsa041140.61010146
70Protein digestion and absorption_Homo sapiens_hsa049740.55592538
71Nitrogen metabolism_Homo sapiens_hsa009100.55239296
72Circadian rhythm_Homo sapiens_hsa047100.54531811
73Glucagon signaling pathway_Homo sapiens_hsa049220.54502593
74Tight junction_Homo sapiens_hsa045300.54274791
75Ras signaling pathway_Homo sapiens_hsa040140.53068758
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53060832
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52762646
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51449773
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51145743
80Hedgehog signaling pathway_Homo sapiens_hsa043400.50935915
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50119684
82Rheumatoid arthritis_Homo sapiens_hsa053230.49004932
83Focal adhesion_Homo sapiens_hsa045100.47445148
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45655804
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45639992
86Wnt signaling pathway_Homo sapiens_hsa043100.44711079
87Rap1 signaling pathway_Homo sapiens_hsa040150.42452191
88Basal cell carcinoma_Homo sapiens_hsa052170.41414926
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40581534
90Alcoholism_Homo sapiens_hsa050340.40507318
91Inositol phosphate metabolism_Homo sapiens_hsa005620.40371696
92Histidine metabolism_Homo sapiens_hsa003400.39933454
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39183623
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38800528
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.37884535
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37641247
97VEGF signaling pathway_Homo sapiens_hsa043700.37383759
98Type I diabetes mellitus_Homo sapiens_hsa049400.32448159
99Bile secretion_Homo sapiens_hsa049760.31813735
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29951459
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29487763
102Mineral absorption_Homo sapiens_hsa049780.29242298
103Ovarian steroidogenesis_Homo sapiens_hsa049130.28854809
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27566121
105Butanoate metabolism_Homo sapiens_hsa006500.26983706
106TGF-beta signaling pathway_Homo sapiens_hsa043500.26613411
107Renal cell carcinoma_Homo sapiens_hsa052110.26160439
108Prion diseases_Homo sapiens_hsa050200.23833568
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22209648
110Phagosome_Homo sapiens_hsa041450.20957844
111Fatty acid biosynthesis_Homo sapiens_hsa000610.20283072
112Melanoma_Homo sapiens_hsa052180.18386176
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.17387135
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13312413
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.12636308
116Ether lipid metabolism_Homo sapiens_hsa005650.12553023

Most similar genes based on co-expression Upload to Enrichr

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