NTMT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.43778453
2maturation of SSU-rRNA (GO:0030490)4.94328135
3ribosomal small subunit assembly (GO:0000028)4.84067687
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.79172188
5termination of RNA polymerase III transcription (GO:0006386)4.59109722
6transcription elongation from RNA polymerase III promoter (GO:0006385)4.59109722
7ribosomal small subunit biogenesis (GO:0042274)4.58782357
8ATP synthesis coupled proton transport (GO:0015986)4.44659561
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.44659561
10proteasome assembly (GO:0043248)4.43554256
11viral transcription (GO:0019083)4.41238174
12translational termination (GO:0006415)4.33930854
13cullin deneddylation (GO:0010388)4.33788439
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.25958101
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.22985172
16respiratory electron transport chain (GO:0022904)4.20350159
17maturation of 5.8S rRNA (GO:0000460)4.19399611
18ribonucleoprotein complex biogenesis (GO:0022613)4.17747290
19ribosome biogenesis (GO:0042254)4.13640990
20electron transport chain (GO:0022900)4.10641762
21protein deneddylation (GO:0000338)4.08996312
22ribosomal large subunit biogenesis (GO:0042273)4.07782874
23nucleobase biosynthetic process (GO:0046112)4.07658259
24rRNA modification (GO:0000154)4.04355115
25purine nucleobase biosynthetic process (GO:0009113)4.03203438
26spliceosomal snRNP assembly (GO:0000387)4.02562740
27formation of translation preinitiation complex (GO:0001731)3.96315762
28negative regulation of ligase activity (GO:0051352)3.94789201
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.94789201
30L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.93953889
31translational elongation (GO:0006414)3.93855067
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.91353876
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.89869459
34translational initiation (GO:0006413)3.89155359
35rRNA processing (GO:0006364)3.86785799
36DNA strand elongation involved in DNA replication (GO:0006271)3.86167459
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.86038512
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.80596004
397-methylguanosine mRNA capping (GO:0006370)3.78314338
40pseudouridine synthesis (GO:0001522)3.75998588
41cotranslational protein targeting to membrane (GO:0006613)3.74539202
42protein complex biogenesis (GO:0070271)3.73388300
43DNA strand elongation (GO:0022616)3.72206217
44rRNA metabolic process (GO:0016072)3.71652894
45RNA capping (GO:0036260)3.70927964
467-methylguanosine RNA capping (GO:0009452)3.70927964
47protein targeting to ER (GO:0045047)3.69259749
48mitochondrial respiratory chain complex assembly (GO:0033108)3.68978822
49chaperone-mediated protein transport (GO:0072321)3.68703149
50cellular component biogenesis (GO:0044085)3.68612821
51ribosome assembly (GO:0042255)3.68361263
52deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.65502768
53protein localization to mitochondrion (GO:0070585)3.62373176
54cellular protein complex disassembly (GO:0043624)3.60811279
55DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.59968205
56regulation of cellular amino acid metabolic process (GO:0006521)3.56902285
57DNA replication initiation (GO:0006270)3.56380065
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55032534
59intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.53556592
60signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.53556592
61translation (GO:0006412)3.52566957
62telomere maintenance via semi-conservative replication (GO:0032201)3.52446746
63protein localization to endoplasmic reticulum (GO:0070972)3.50995878
64establishment of integrated proviral latency (GO:0075713)3.50791366
65signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.50325764
66signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.50325764
67signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.50325764
68establishment of viral latency (GO:0019043)3.48879283
69DNA replication checkpoint (GO:0000076)3.48662362
70establishment of protein localization to endoplasmic reticulum (GO:0072599)3.47510635
71viral mRNA export from host cell nucleus (GO:0046784)3.44943754
72positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.44775116
73viral life cycle (GO:0019058)3.44744849
74establishment of protein localization to mitochondrial membrane (GO:0090151)3.44239553
75protein maturation by protein folding (GO:0022417)3.43921782
76signal transduction involved in DNA integrity checkpoint (GO:0072401)3.40527344
77signal transduction involved in DNA damage checkpoint (GO:0072422)3.40527344
78regulation of mitochondrial translation (GO:0070129)3.38716949
79guanosine-containing compound biosynthetic process (GO:1901070)3.37874113
80nucleobase-containing small molecule interconversion (GO:0015949)3.36973125
81signal transduction involved in cell cycle checkpoint (GO:0072395)3.36067808
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.35291906
83oxidative phosphorylation (GO:0006119)3.33499367
84rRNA methylation (GO:0031167)3.32975902
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.32932253
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.32932253
87positive regulation of ligase activity (GO:0051351)3.31146315
88peptidyl-histidine modification (GO:0018202)3.31142758
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30131185
90protein neddylation (GO:0045116)3.28134170
91mitotic metaphase plate congression (GO:0007080)3.26635771
92pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.26561427
93protein targeting to mitochondrion (GO:0006626)3.25399075
94spliceosomal complex assembly (GO:0000245)3.22388130
95DNA damage response, detection of DNA damage (GO:0042769)3.22261367
96respiratory chain complex IV assembly (GO:0008535)3.21700368
97protein complex disassembly (GO:0043241)3.20935507
98establishment of protein localization to mitochondrion (GO:0072655)3.20854269
99transcription elongation from RNA polymerase I promoter (GO:0006362)3.20635718
100GTP biosynthetic process (GO:0006183)3.19122228
101regulation of ubiquitin-protein transferase activity (GO:0051438)3.19060056
102transcription from RNA polymerase I promoter (GO:0006360)3.18654819
103transcription-coupled nucleotide-excision repair (GO:0006283)3.17115601
104termination of RNA polymerase I transcription (GO:0006363)3.14739184
105chromatin remodeling at centromere (GO:0031055)3.14231868
106CENP-A containing nucleosome assembly (GO:0034080)3.14035714
107IMP biosynthetic process (GO:0006188)3.11327857
108pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.10899022
109macromolecular complex disassembly (GO:0032984)3.08874467
110regulation of ligase activity (GO:0051340)3.08701407
111UTP biosynthetic process (GO:0006228)3.06723484
112inner mitochondrial membrane organization (GO:0007007)3.06363547
113telomere maintenance via recombination (GO:0000722)3.05887092
114mitochondrial respiratory chain complex I assembly (GO:0032981)3.05643748
115NADH dehydrogenase complex assembly (GO:0010257)3.05643748
116mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.05643748
117cytochrome complex assembly (GO:0017004)3.03383450
118tRNA aminoacylation for protein translation (GO:0006418)3.03089735

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.73363862
2E2F7_22180533_ChIP-Seq_HELA_Human4.71634121
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.23665115
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.99010869
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.93018839
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.91192713
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.78634843
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.65621151
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.48567719
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.37328191
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.35723346
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.26624500
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.20427361
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.11074889
15MYC_19030024_ChIP-ChIP_MESCs_Mouse3.05153866
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.02777884
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.97518586
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78652369
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71175707
20XRN2_22483619_ChIP-Seq_HELA_Human2.67976024
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.51845291
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.47504516
23VDR_23849224_ChIP-Seq_CD4+_Human2.42241770
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38015837
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.37781924
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33586378
27DCP1A_22483619_ChIP-Seq_HELA_Human2.31518893
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29485129
29GABP_19822575_ChIP-Seq_HepG2_Human2.26433776
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24222204
31TTF2_22483619_ChIP-Seq_HELA_Human2.22151011
32YY1_21170310_ChIP-Seq_MESCs_Mouse2.19855670
33SRF_21415370_ChIP-Seq_HL-1_Mouse2.17042123
34FOXP3_21729870_ChIP-Seq_TREG_Human2.07455837
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94116929
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.91532384
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80916246
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79641590
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78091375
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77148593
41ELK1_19687146_ChIP-ChIP_HELA_Human1.75017021
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72212466
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70364095
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66717800
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61608274
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61379839
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60441747
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51207037
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50783045
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.50777853
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.50755693
52CIITA_25753668_ChIP-Seq_RAJI_Human1.50234276
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47878194
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47273357
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.41441182
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38928459
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38776176
58ZNF263_19887448_ChIP-Seq_K562_Human1.38003936
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34933379
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34309347
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31887236
62AR_21909140_ChIP-Seq_LNCAP_Human1.31819407
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27025729
64DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26929477
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26711763
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23459269
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22947505
68KDM5A_27292631_Chip-Seq_BREAST_Human1.22704845
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22063406
70MYC_18940864_ChIP-ChIP_HL60_Human1.21586624
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20819878
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.20758834
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19948486
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.19715518
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13433220
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12537000
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10631073
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09293166
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.08744849
80CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08514284
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04816821
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02662534
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01797735
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01627245
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.01118370
86KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99974025
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99618631
88TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99053261
89CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94321976
90STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94258599
91SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94199396
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93003664
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92082630
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91907982
95IRF1_19129219_ChIP-ChIP_H3396_Human0.91414486
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91217030
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90152650
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89612511
99OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87223147
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86803885
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86243841
102TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86187895
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85630234
104SOX17_20123909_ChIP-Seq_XEN_Mouse0.85543511
105YY1_22570637_ChIP-Seq_MALME-3M_Human0.85223175
106SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83081237
107SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82328232
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79584908
109TFEB_21752829_ChIP-Seq_HELA_Human0.79581230
110EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79008304
111SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.78326407
112FOXP1_21924763_ChIP-Seq_HESCs_Human0.78301131
113NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77622244

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.08429209
2MP0003806_abnormal_nucleotide_metabolis3.37566430
3MP0004957_abnormal_blastocyst_morpholog3.35336632
4MP0010094_abnormal_chromosome_stability3.10905727
5MP0003111_abnormal_nucleus_morphology3.09176282
6MP0008058_abnormal_DNA_repair3.02250400
7MP0003077_abnormal_cell_cycle3.00556284
8MP0003123_paternal_imprinting2.92846257
9MP0009379_abnormal_foot_pigmentation2.91939498
10MP0008007_abnormal_cellular_replicative2.85073204
11MP0006292_abnormal_olfactory_placode2.77780836
12MP0008932_abnormal_embryonic_tissue2.71771216
13MP0008057_abnormal_DNA_replication2.65335944
14MP0010030_abnormal_orbit_morphology2.46116596
15MP0001529_abnormal_vocalization2.45974136
16MP0002102_abnormal_ear_morphology2.32006596
17MP0002653_abnormal_ependyma_morphology2.27194556
18MP0003718_maternal_effect2.20124146
19MP0002163_abnormal_gland_morphology1.94804427
20MP0003315_abnormal_perineum_morphology1.81983435
21MP0002938_white_spotting1.81791991
22MP0000749_muscle_degeneration1.79446851
23MP0003786_premature_aging1.70131740
24MP0001730_embryonic_growth_arrest1.62652362
25MP0003121_genomic_imprinting1.56237648
26MP0000751_myopathy1.54228556
27MP0003122_maternal_imprinting1.53392663
28MP0000350_abnormal_cell_proliferation1.49907921
29MP0000049_abnormal_middle_ear1.49827423
30MP0004133_heterotaxia1.42968653
31MP0003938_abnormal_ear_development1.42327248
32MP0004233_abnormal_muscle_weight1.41138951
33MP0005330_cardiomyopathy1.39066769
34MP0006276_abnormal_autonomic_nervous1.36653877
35MP0008877_abnormal_DNA_methylation1.31499614
36MP0001905_abnormal_dopamine_level1.28690165
37MP0002751_abnormal_autonomic_nervous1.27226106
38MP0005075_abnormal_melanosome_morpholog1.24202589
39MP0008789_abnormal_olfactory_epithelium1.22497389
40MP0001697_abnormal_embryo_size1.19874044
41MP0003942_abnormal_urinary_system1.19390802
42MP0005623_abnormal_meninges_morphology1.16690800
43MP0005501_abnormal_skin_physiology1.16689978
44MP0000358_abnormal_cell_content/1.15854260
45MP0006036_abnormal_mitochondrial_physio1.14934445
46MP0001672_abnormal_embryogenesis/_devel1.14851576
47MP0005380_embryogenesis_phenotype1.14851576
48MP0002080_prenatal_lethality1.14209303
49MP0002638_abnormal_pupillary_reflex1.14187382
50MP0000015_abnormal_ear_pigmentation1.12851649
51MP0000372_irregular_coat_pigmentation1.11935374
52MP0002210_abnormal_sex_determination1.11029529
53MP0001188_hyperpigmentation1.10986007
54MP0006035_abnormal_mitochondrial_morpho1.09954004
55MP0003221_abnormal_cardiomyocyte_apopto1.09884271
56MP0002085_abnormal_embryonic_tissue1.09552712
57MP0000750_abnormal_muscle_regeneration1.08862556
58MP0008260_abnormal_autophagy1.08162649
59MP0002396_abnormal_hematopoietic_system1.07822686
60MP0001764_abnormal_homeostasis1.07453566
61MP0003567_abnormal_fetal_cardiomyocyte1.07107248
62MP0000313_abnormal_cell_death1.06836860
63MP0000537_abnormal_urethra_morphology1.06665707
64MP0005257_abnormal_intraocular_pressure1.06390804
65MP0003011_delayed_dark_adaptation1.05912922
66MP0002877_abnormal_melanocyte_morpholog1.04206416
67MP0002160_abnormal_reproductive_system1.03648929
68MP0002269_muscular_atrophy1.03463362
69MP0001661_extended_life_span1.03319650
70MP0009672_abnormal_birth_weight1.02791311
71MP0003186_abnormal_redox_activity1.02067924
72MP0001145_abnormal_male_reproductive1.01988174
73MP0002736_abnormal_nociception_after1.01320837
74MP0003890_abnormal_embryonic-extraembry1.00866200
75MP0000566_synostosis1.00561210
76MP0003984_embryonic_growth_retardation1.00082068
77MP0009333_abnormal_splenocyte_physiolog0.99714552
78MP0001727_abnormal_embryo_implantation0.97988543
79MP0004145_abnormal_muscle_electrophysio0.97938411
80MP0002234_abnormal_pharynx_morphology0.96944832
81MP0001929_abnormal_gametogenesis0.96238032
82MP0002088_abnormal_embryonic_growth/wei0.96227238
83MP0005174_abnormal_tail_pigmentation0.95332535
84MP0009053_abnormal_anal_canal0.95012071
85MP0003937_abnormal_limbs/digits/tail_de0.94559931
86MP0001293_anophthalmia0.92962452
87MP0000747_muscle_weakness0.92900526
88MP0004084_abnormal_cardiac_muscle0.92785112
89MP0003119_abnormal_digestive_system0.91082223
90MP0005410_abnormal_fertilization0.90937294
91MP0002084_abnormal_developmental_patter0.89222063
92MP0003137_abnormal_impulse_conducting0.87231098
93MP0005451_abnormal_body_composition0.87183561
94MP0000653_abnormal_sex_gland0.85237652
95MP0003861_abnormal_nervous_system0.84596854
96MP0005499_abnormal_olfactory_system0.83796888
97MP0005394_taste/olfaction_phenotype0.83796888
98MP0000678_abnormal_parathyroid_gland0.83777564
99MP0003646_muscle_fatigue0.82113744
100MP0001881_abnormal_mammary_gland0.79679256
101MP0000759_abnormal_skeletal_muscle0.79259099
102MP0002132_abnormal_respiratory_system0.78986191
103MP0002282_abnormal_trachea_morphology0.78062441
104MP0003698_abnormal_male_reproductive0.75929917
105MP0000428_abnormal_craniofacial_morphol0.75689577
106MP0000490_abnormal_crypts_of0.75078828
107MP0005266_abnormal_metabolism0.74987871
108MP0002249_abnormal_larynx_morphology0.74328547
109MP0000762_abnormal_tongue_morphology0.73680359
110MP0009250_abnormal_appendicular_skeleto0.73445321
111MP0002177_abnormal_outer_ear0.72898327
112MP0002114_abnormal_axial_skeleton0.72505311
113MP0002019_abnormal_tumor_incidence0.72376857
114MP0003385_abnormal_body_wall0.71988542
115MP0005332_abnormal_amino_acid0.71691083
116MP0001542_abnormal_bone_strength0.70454524
117MP0005084_abnormal_gallbladder_morpholo0.70259934
118MP0006072_abnormal_retinal_apoptosis0.69092822
119MP0005083_abnormal_biliary_tract0.68947387
120MP0001346_abnormal_lacrimal_gland0.68542591
121MP0000631_abnormal_neuroendocrine_gland0.68113863
122MP0002095_abnormal_skin_pigmentation0.67078748
123MP0002127_abnormal_cardiovascular_syste0.66583257
124MP0002697_abnormal_eye_size0.66546930
125MP0003941_abnormal_skin_development0.65494581
126MP0005389_reproductive_system_phenotype0.65417913
127MP0009697_abnormal_copulation0.63788255
128MP0002111_abnormal_tail_morphology0.63418364
129MP0002106_abnormal_muscle_physiology0.61493210
130MP0003880_abnormal_central_pattern0.60704165
131MP0003183_abnormal_peptide_metabolism0.60528877
132MP0005408_hypopigmentation0.59778733
133MP0004087_abnormal_muscle_fiber0.59215178
134MP0001119_abnormal_female_reproductive0.59091492
135MP0010307_abnormal_tumor_latency0.59051478
136MP0000778_abnormal_nervous_system0.58505728
137MP0005384_cellular_phenotype0.57909726
138MP0002796_impaired_skin_barrier0.57879743
139MP0000534_abnormal_ureter_morphology0.57054696
140MP0003136_yellow_coat_color0.57028508

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)4.43520966
2Abnormality of cells of the erythroid lineage (HP:0012130)4.19547082
3Acute necrotizing encephalopathy (HP:0006965)4.17986155
4Hepatocellular necrosis (HP:0001404)3.98633016
5Abnormal mitochondria in muscle tissue (HP:0008316)3.94445468
6Mitochondrial inheritance (HP:0001427)3.82907829
7Birth length less than 3rd percentile (HP:0003561)3.79842469
8Abnormal number of erythroid precursors (HP:0012131)3.78436752
9Reticulocytopenia (HP:0001896)3.77949534
10Renal Fanconi syndrome (HP:0001994)3.73392838
11Cerebral edema (HP:0002181)3.70825901
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.65584532
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.65584532
14Abnormality of glycolysis (HP:0004366)3.50167956
15Increased serum pyruvate (HP:0003542)3.50167956
16Increased CSF lactate (HP:0002490)3.50163946
17Rough bone trabeculation (HP:0100670)3.19303182
18Increased muscle lipid content (HP:0009058)3.15836995
19Increased serum lactate (HP:0002151)3.15521044
20Hepatic necrosis (HP:0002605)3.12820188
21Breast hypoplasia (HP:0003187)3.06940417
22Progressive macrocephaly (HP:0004481)3.01522747
23Macrocytic anemia (HP:0001972)3.00885533
24Acute encephalopathy (HP:0006846)3.00004034
25Aplastic anemia (HP:0001915)2.99439776
26Oral leukoplakia (HP:0002745)2.88246331
27Carpal bone hypoplasia (HP:0001498)2.85303529
28Pallor (HP:0000980)2.84807886
29CNS hypomyelination (HP:0003429)2.78552305
303-Methylglutaconic aciduria (HP:0003535)2.77761087
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.73014879
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.70168475
33Exercise intolerance (HP:0003546)2.68629225
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.66320694
35Respiratory difficulties (HP:0002880)2.65002098
36Testicular atrophy (HP:0000029)2.57940730
37Type I transferrin isoform profile (HP:0003642)2.53832054
38Increased hepatocellular lipid droplets (HP:0006565)2.52805932
39Microretrognathia (HP:0000308)2.51568134
40Colon cancer (HP:0003003)2.49907197
41Ragged-red muscle fibers (HP:0003200)2.48877160
42Type 2 muscle fiber atrophy (HP:0003554)2.46765040
43Abnormality of placental membranes (HP:0011409)2.45780998
44Amniotic constriction ring (HP:0009775)2.45780998
45Patellar aplasia (HP:0006443)2.44523819
46Muscle fiber atrophy (HP:0100295)2.38734766
47Selective tooth agenesis (HP:0001592)2.35638504
48Pancreatic fibrosis (HP:0100732)2.35458553
49Lactic acidosis (HP:0003128)2.33177095
50Respiratory failure (HP:0002878)2.32425659
51Aplasia/Hypoplasia of the patella (HP:0006498)2.32256976
52Horseshoe kidney (HP:0000085)2.31444418
53Emotional lability (HP:0000712)2.31116582
54Trismus (HP:0000211)2.27342854
55Cholecystitis (HP:0001082)2.25825703
56Abnormal gallbladder physiology (HP:0012438)2.25825703
57Glossoptosis (HP:0000162)2.25607192
58Abnormal trabecular bone morphology (HP:0100671)2.25466545
59Secondary amenorrhea (HP:0000869)2.25457421
60Stenosis of the external auditory canal (HP:0000402)2.22309318
61Premature graying of hair (HP:0002216)2.21007834
62CNS demyelination (HP:0007305)2.20790139
63Cleft eyelid (HP:0000625)2.19681416
64Delusions (HP:0000746)2.18694607
65Aplasia/hypoplasia of the uterus (HP:0008684)2.17138662
66Lethargy (HP:0001254)2.16923704
67Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.16480671
68Pancreatic cysts (HP:0001737)2.14678571
69Lipid accumulation in hepatocytes (HP:0006561)2.14623570
70Nemaline bodies (HP:0003798)2.12924686
71Sparse eyelashes (HP:0000653)2.09566965
72Abnormality of alanine metabolism (HP:0010916)2.08400022
73Hyperalaninemia (HP:0003348)2.08400022
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08400022
75Progressive muscle weakness (HP:0003323)2.07606728
76Postnatal microcephaly (HP:0005484)2.05567954
77Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.03749098
78Hypoplasia of the capital femoral epiphysis (HP:0003090)2.02340815
79Premature ovarian failure (HP:0008209)2.02236423
80Multiple enchondromatosis (HP:0005701)2.02106224
81Increased intramyocellular lipid droplets (HP:0012240)2.01934149
82Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00230343
8311 pairs of ribs (HP:0000878)1.98707176
84Exertional dyspnea (HP:0002875)1.98376463
85Unsteady gait (HP:0002317)1.98014001
86Abnormality of the umbilical cord (HP:0010881)1.97728894
87Supernumerary spleens (HP:0009799)1.97005095
88Muscle fiber inclusion bodies (HP:0100299)1.95803523
89Methylmalonic aciduria (HP:0012120)1.95581348
90Abnormal protein glycosylation (HP:0012346)1.94546796
91Abnormal glycosylation (HP:0012345)1.94546796
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94546796
93Abnormal protein N-linked glycosylation (HP:0012347)1.94546796
94Squamous cell carcinoma (HP:0002860)1.91949663
95Hypoplastic pelvis (HP:0008839)1.91756320
96Leukodystrophy (HP:0002415)1.91675457
97Redundant skin (HP:0001582)1.90707205
98Abnormal lung lobation (HP:0002101)1.90485809
99Facial cleft (HP:0002006)1.89826013
100Degeneration of anterior horn cells (HP:0002398)1.89685897
101Abnormality of the anterior horn cell (HP:0006802)1.89685897
102Opisthotonus (HP:0002179)1.89338455
103Abnormalities of placenta or umbilical cord (HP:0001194)1.89271658
104Hypokinesia (HP:0002375)1.88803177
105Abnormality of the preputium (HP:0100587)1.88237082
106Triphalangeal thumb (HP:0001199)1.88047664
107True hermaphroditism (HP:0010459)1.86659034
108Absent radius (HP:0003974)1.84148985
109Neoplasm of the pancreas (HP:0002894)1.82814754
110X-linked dominant inheritance (HP:0001423)1.82462562
111Absent thumb (HP:0009777)1.81655032
112Abnormal number of incisors (HP:0011064)1.81376851
113Abnormality of renal resorption (HP:0011038)1.80222465
114Anencephaly (HP:0002323)1.80092285
115Poor suck (HP:0002033)1.79948967
116Hypoplasia of the radius (HP:0002984)1.79021425
117Optic disc pallor (HP:0000543)1.78336934
118Aplasia involving forearm bones (HP:0009822)1.77995943
119Absent forearm bone (HP:0003953)1.77995943
120Congenital malformation of the right heart (HP:0011723)1.77322229
121Double outlet right ventricle (HP:0001719)1.77322229
122Generalized aminoaciduria (HP:0002909)1.75089979
123Abnormality of the labia minora (HP:0012880)1.74745980
124Cellular immunodeficiency (HP:0005374)1.73692546
125Meckel diverticulum (HP:0002245)1.73239646
126Aplasia/Hypoplasia of the uvula (HP:0010293)1.71598720
127Hypoplasia of the uterus (HP:0000013)1.71441929
128Reduced antithrombin III activity (HP:0001976)1.71309337
129Blindness (HP:0000618)1.71073060
130Myopathic facies (HP:0002058)1.70893228
131Delayed CNS myelination (HP:0002188)1.70768893
132Abnormality of the ileum (HP:0001549)1.69507090
133Exercise-induced muscle cramps (HP:0003710)1.68889748
134Microvesicular hepatic steatosis (HP:0001414)1.68499154
135Pancytopenia (HP:0001876)1.67955025
136Chromsome breakage (HP:0040012)1.67854721
137Sclerocornea (HP:0000647)1.67505837

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.14459201
2VRK24.93639844
3EIF2AK14.41654546
4STK163.48261544
5WEE13.43019347
6NME23.22231583
7TLK12.42416856
8PIM22.38028193
9SRPK12.31865721
10TESK22.03200275
11TSSK61.99723614
12CDC71.96264556
13VRK11.91336217
14PDK21.90969615
15EIF2AK31.89537335
16PLK41.87889002
17BCKDK1.85410734
18MKNK11.83689705
19ACVR1B1.81973228
20DYRK31.73427524
21DYRK21.72162483
22BRSK21.71640398
23LIMK11.56370399
24NME11.56030998
25ARAF1.53952597
26PLK11.47477263
27LATS21.40448690
28BRAF1.40384618
29PASK1.40023459
30BRSK11.37354515
31TESK11.37079679
32AURKA1.33720468
33TAF11.30826412
34CDK191.30483607
35CCNB11.30037916
36CDK81.24427296
37PLK31.18498542
38AURKB1.17887099
39IRAK31.17657961
40BCR1.17350024
41MAP3K121.15708341
42CDK71.13666652
43SMG11.11967451
44ILK1.10866325
45NEK11.10382466
46MYLK1.09751408
47SIK31.07146956
48TRIM281.05624771
49STK38L1.02847633
50MAP3K111.01293908
51NEK20.99918278
52TTK0.98323737
53CASK0.96846118
54STK240.96527031
55TAOK20.95031111
56MKNK20.94641861
57PAK10.94577930
58MAPKAPK50.92636953
59STK40.91006964
60ATR0.90749768
61CHEK20.90632751
62RPS6KB20.88364103
63TGFBR10.84791462
64MAP2K30.79110327
65MAP4K20.76533753
66MST1R0.74066778
67PAK40.73621147
68NUAK10.73090010
69PBK0.73038899
70PRKCI0.69312833
71RPS6KA40.69015862
72MAP3K30.67759486
73MUSK0.67416686
74PDK30.65195503
75PDK40.65195503
76MARK10.64705375
77ZAK0.64072125
78CSNK2A20.62901494
79PHKG20.62454897
80PHKG10.62454897
81CHEK10.62366242
82ADRBK20.61757920
83CSNK2A10.60651832
84ERBB40.58507106
85STK100.58453681
86LRRK20.58074208
87EIF2AK20.57665189
88MAP2K70.57233932
89CAMK2G0.55260881
90ABL20.54644678
91EPHA20.52230630
92CDK180.51547036
93CSNK1A1L0.50365408
94CSNK1G30.50341624
95DAPK30.49921524
96CSNK1G20.49136742
97MAP3K80.48922451
98CSNK1G10.48694908
99MAPK130.48628175
100UHMK10.48579613
101TTN0.47517758
102AKT30.47464890
103EPHB20.47028882
104CDK140.46624602
105CDK11A0.46065291
106MINK10.45791071
107RAF10.45745682
108MAP2K60.44593227
109CDK150.42133670
110CLK10.41891549
111RPS6KA50.41551301
112MAP3K90.40188473
113CDK20.39987969
114KSR10.37794310
115KDR0.37265353
116MAPKAPK30.36683764
117CAMK2D0.35846846
118OBSCN0.33611328
119MST40.33419374
120CDK40.32053315
121MOS0.31451802
122AKT20.31246126
123SCYL20.31124027
124ATM0.30173522
125CDK10.28569318
126DAPK10.27634976
127PAK20.26531583

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.47605614
2Ribosome_Homo sapiens_hsa030104.43319225
3RNA polymerase_Homo sapiens_hsa030204.42793987
4DNA replication_Homo sapiens_hsa030303.74613061
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.45033212
6Mismatch repair_Homo sapiens_hsa034303.13548905
7Oxidative phosphorylation_Homo sapiens_hsa001902.98802079
8Spliceosome_Homo sapiens_hsa030402.90219485
9Parkinsons disease_Homo sapiens_hsa050122.89365545
10Pyrimidine metabolism_Homo sapiens_hsa002402.76890188
11RNA transport_Homo sapiens_hsa030132.65546663
12Homologous recombination_Homo sapiens_hsa034402.39841093
13Base excision repair_Homo sapiens_hsa034102.37080610
14Nucleotide excision repair_Homo sapiens_hsa034202.34857805
15Huntingtons disease_Homo sapiens_hsa050162.20365209
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07866864
17Cell cycle_Homo sapiens_hsa041101.98309863
18Basal transcription factors_Homo sapiens_hsa030221.89085287
19RNA degradation_Homo sapiens_hsa030181.75858126
20Alzheimers disease_Homo sapiens_hsa050101.69717090
21Purine metabolism_Homo sapiens_hsa002301.69097063
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60240310
23Fanconi anemia pathway_Homo sapiens_hsa034601.54838264
24Protein export_Homo sapiens_hsa030601.51581599
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38781639
26Non-homologous end-joining_Homo sapiens_hsa034501.34258847
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28446860
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23808965
29Cardiac muscle contraction_Homo sapiens_hsa042601.21848200
30One carbon pool by folate_Homo sapiens_hsa006701.19878165
31mRNA surveillance pathway_Homo sapiens_hsa030151.13809341
32Epstein-Barr virus infection_Homo sapiens_hsa051691.12160065
33Vitamin B6 metabolism_Homo sapiens_hsa007501.11961162
34p53 signaling pathway_Homo sapiens_hsa041151.11240391
35Sulfur relay system_Homo sapiens_hsa041221.04812019
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04765061
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96964987
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93984681
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.91923584
40Pentose phosphate pathway_Homo sapiens_hsa000300.89135146
41Biosynthesis of amino acids_Homo sapiens_hsa012300.86024095
42Sulfur metabolism_Homo sapiens_hsa009200.84650350
43Selenocompound metabolism_Homo sapiens_hsa004500.84498898
44Oocyte meiosis_Homo sapiens_hsa041140.78433854
45Folate biosynthesis_Homo sapiens_hsa007900.75025190
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73508363
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71940527
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71155084
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69115285
50N-Glycan biosynthesis_Homo sapiens_hsa005100.64012706
51Propanoate metabolism_Homo sapiens_hsa006400.63553940
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61552009
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59638905
54Systemic lupus erythematosus_Homo sapiens_hsa053220.57385456
55Glutathione metabolism_Homo sapiens_hsa004800.56395977
56Metabolic pathways_Homo sapiens_hsa011000.56248232
57Fructose and mannose metabolism_Homo sapiens_hsa000510.55448197
58Vibrio cholerae infection_Homo sapiens_hsa051100.55326985
59Arachidonic acid metabolism_Homo sapiens_hsa005900.52972501
60Carbon metabolism_Homo sapiens_hsa012000.49149656
61Alcoholism_Homo sapiens_hsa050340.45802094
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42913411
63Pyruvate metabolism_Homo sapiens_hsa006200.42258889
64Hedgehog signaling pathway_Homo sapiens_hsa043400.41677669
65Peroxisome_Homo sapiens_hsa041460.39375048
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38676429
67Collecting duct acid secretion_Homo sapiens_hsa049660.38260808
68Viral carcinogenesis_Homo sapiens_hsa052030.38141520
69Galactose metabolism_Homo sapiens_hsa000520.37596406
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37220502
71Basal cell carcinoma_Homo sapiens_hsa052170.35982680
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35309769
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35170031
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33696943
75Hippo signaling pathway_Homo sapiens_hsa043900.33311366
76Arginine and proline metabolism_Homo sapiens_hsa003300.31822856
77Linoleic acid metabolism_Homo sapiens_hsa005910.30245214
78Shigellosis_Homo sapiens_hsa051310.30010636
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28199091
80Fatty acid metabolism_Homo sapiens_hsa012120.28076579
81HTLV-I infection_Homo sapiens_hsa051660.28068940
82Regulation of autophagy_Homo sapiens_hsa041400.27890601
83Thyroid cancer_Homo sapiens_hsa052160.27755749
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27691997
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26920108
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.25989791
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25814577
88Phenylalanine metabolism_Homo sapiens_hsa003600.25284250
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.24971516
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22099380
91Tyrosine metabolism_Homo sapiens_hsa003500.20598066
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20355211
93Bladder cancer_Homo sapiens_hsa052190.19349705
94HIF-1 signaling pathway_Homo sapiens_hsa040660.18756429
95Steroid biosynthesis_Homo sapiens_hsa001000.18491125
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18087315
97beta-Alanine metabolism_Homo sapiens_hsa004100.17053177
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15497691
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13520360
100Legionellosis_Homo sapiens_hsa051340.13462564
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.13054939
102TGF-beta signaling pathway_Homo sapiens_hsa043500.12598625
103Fatty acid degradation_Homo sapiens_hsa000710.11787270
104Type I diabetes mellitus_Homo sapiens_hsa049400.11758318
105Herpes simplex infection_Homo sapiens_hsa051680.11580038
106Fatty acid elongation_Homo sapiens_hsa000620.10355502
107Arginine biosynthesis_Homo sapiens_hsa002200.10233177
108Synaptic vesicle cycle_Homo sapiens_hsa047210.09515453
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09425225
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.08677063
111Colorectal cancer_Homo sapiens_hsa052100.08271147
112Vitamin digestion and absorption_Homo sapiens_hsa049770.07659972
113Rheumatoid arthritis_Homo sapiens_hsa053230.07153644
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.07122331
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.06660388
116Melanoma_Homo sapiens_hsa052180.06287714
117Ether lipid metabolism_Homo sapiens_hsa005650.05978889
118Butanoate metabolism_Homo sapiens_hsa006500.04889613
119MicroRNAs in cancer_Homo sapiens_hsa052060.03993559
120Tight junction_Homo sapiens_hsa045300.03379633
121Pathways in cancer_Homo sapiens_hsa052000.02930797
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.02869673
123Wnt signaling pathway_Homo sapiens_hsa043100.01658569

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