NTN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)5.67338173
2limb bud formation (GO:0060174)5.20663448
3sarcomere organization (GO:0045214)5.18095190
4radial glial cell differentiation (GO:0060019)5.16603157
5negative regulation of potassium ion transmembrane transport (GO:1901380)5.00715754
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.99165579
7neuronal stem cell maintenance (GO:0097150)4.74067995
8otic vesicle formation (GO:0030916)4.71750180
9plasma membrane repair (GO:0001778)4.51251271
10myofibril assembly (GO:0030239)4.50080664
11glomerular filtration (GO:0003094)4.46543977
12positive regulation of vascular permeability (GO:0043117)4.34187664
13camera-type eye morphogenesis (GO:0048593)4.23149132
14negative regulation of axon guidance (GO:1902668)4.22095164
15renal filtration (GO:0097205)4.19980633
16cardiac muscle cell development (GO:0055013)4.19931898
17cardiac cell development (GO:0055006)4.15319177
18axonemal dynein complex assembly (GO:0070286)4.12008245
19heart trabecula formation (GO:0060347)4.08846964
20glomerular basement membrane development (GO:0032836)4.04837054
21paraxial mesoderm development (GO:0048339)4.03764847
22planar cell polarity pathway involved in neural tube closure (GO:0090179)4.02080488
23cardiac muscle contraction (GO:0060048)3.97983983
24lateral sprouting from an epithelium (GO:0060601)3.88029745
25non-canonical Wnt signaling pathway (GO:0035567)3.80116851
26ventricular cardiac muscle cell action potential (GO:0086005)3.79688066
27regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.72206635
28regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.71498111
29regulation of axon guidance (GO:1902667)3.70306204
30actomyosin structure organization (GO:0031032)3.64787530
31regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.63254448
32ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.63191985
33negative regulation of oligodendrocyte differentiation (GO:0048715)3.58365841
34mesenchymal-epithelial cell signaling (GO:0060638)3.57387744
35astrocyte differentiation (GO:0048708)3.57112453
36axon extension involved in axon guidance (GO:0048846)3.55206602
37neuron projection extension involved in neuron projection guidance (GO:1902284)3.55206602
38adult heart development (GO:0007512)3.55143411
39cardiac muscle cell proliferation (GO:0060038)3.53336146
40peripheral nervous system axon ensheathment (GO:0032292)3.52486431
41myelination in peripheral nervous system (GO:0022011)3.52486431
42neuron fate determination (GO:0048664)3.51736077
43tricarboxylic acid cycle (GO:0006099)3.51577778
44positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.50282814
45branching involved in salivary gland morphogenesis (GO:0060445)3.49772561
46pyrimidine nucleobase catabolic process (GO:0006208)3.49345271
47regulation of cardioblast differentiation (GO:0051890)3.47676162
48actin-myosin filament sliding (GO:0033275)3.43806471
49muscle filament sliding (GO:0030049)3.43806471
50cell-cell signaling involved in cell fate commitment (GO:0045168)3.43524248
51cardiac muscle tissue morphogenesis (GO:0055008)3.41712533
52bundle of His cell to Purkinje myocyte communication (GO:0086069)3.36952817
53retinal ganglion cell axon guidance (GO:0031290)3.35902489
54* establishment of nucleus localization (GO:0040023)3.31919425
55asymmetric protein localization (GO:0008105)3.31556615
56trabecula formation (GO:0060343)3.29754584
57apical protein localization (GO:0045176)3.29016634
58embryonic camera-type eye development (GO:0031076)3.27286598
59regulation of establishment of planar polarity (GO:0090175)3.23219870
60cilium or flagellum-dependent cell motility (GO:0001539)3.22856068
61regulation of heart morphogenesis (GO:2000826)3.21286465
62midbrain development (GO:0030901)3.21112357
63negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.16871312
64regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.16488182
65negative regulation of axon extension involved in axon guidance (GO:0048843)3.12760238
66regulation of actin filament-based movement (GO:1903115)3.11597392
67cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.11169841
68carnitine shuttle (GO:0006853)3.10126553
69lung epithelium development (GO:0060428)3.09929256
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09229138
71epithelial cell-cell adhesion (GO:0090136)3.09198310
72cilium movement (GO:0003341)3.09184517
73muscle tissue morphogenesis (GO:0060415)3.08978501
74axonal fasciculation (GO:0007413)3.08828979
75organ growth (GO:0035265)3.08559305
76regulation of secondary heart field cardioblast proliferation (GO:0003266)3.07774628
77regulation of cardioblast proliferation (GO:0003264)3.07774628
78striated muscle cell proliferation (GO:0014855)3.07055345
79neuron projection regeneration (GO:0031102)3.06984052
80regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.06910833
81regulation of vascular permeability (GO:0043114)3.05628785
82protein heterotrimerization (GO:0070208)3.05622951
83cell communication by electrical coupling (GO:0010644)3.04602741
84lens fiber cell development (GO:0070307)3.04375245
85cell communication involved in cardiac conduction (GO:0086065)3.04070020
86cell proliferation involved in kidney development (GO:0072111)3.03167144
87regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.01297919
88renal system development (GO:0072001)2.99860104
89cell proliferation involved in metanephros development (GO:0072203)2.97942348
90regulation of axon extension involved in axon guidance (GO:0048841)2.97800053
91outer ear morphogenesis (GO:0042473)2.96297358
92endocardial cushion morphogenesis (GO:0003203)2.96073404
93ventricular trabecula myocardium morphogenesis (GO:0003222)2.95679952
94postsynaptic membrane organization (GO:0001941)2.95327995
95spinal cord development (GO:0021510)2.93006634
96regulation of membrane repolarization (GO:0060306)2.92837643
97establishment of apical/basal cell polarity (GO:0035089)2.92302213
98heart morphogenesis (GO:0003007)2.91808475
99presynaptic membrane assembly (GO:0097105)2.91620427
100actin-mediated cell contraction (GO:0070252)2.91203954
101cardiac muscle hypertrophy (GO:0003300)2.90998041
102axon regeneration (GO:0031103)2.89321359
103striated muscle hypertrophy (GO:0014897)2.88679475
104establishment of planar polarity (GO:0001736)2.88637771
105establishment of tissue polarity (GO:0007164)2.88637771
106negative chemotaxis (GO:0050919)2.88057746
107cochlea morphogenesis (GO:0090103)2.85686801
108muscle cell proliferation (GO:0033002)2.84420597
109regulation of organ formation (GO:0003156)2.84159797
110hippo signaling (GO:0035329)2.84002322
111primitive streak formation (GO:0090009)2.82721182
112dopaminergic neuron differentiation (GO:0071542)2.82332128
113axis elongation (GO:0003401)2.81814665
114positive regulation of gastrulation (GO:2000543)2.80459435
115developmental induction (GO:0031128)2.79718800
116ventricular cardiac muscle cell development (GO:0055015)2.79233567
117axon ensheathment in central nervous system (GO:0032291)2.77335896
118central nervous system myelination (GO:0022010)2.77335896
119regulation of the force of heart contraction (GO:0002026)2.77283410
120regulation of p38MAPK cascade (GO:1900744)2.77101598
121branch elongation of an epithelium (GO:0060602)2.76501583
122positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.75645366
123somite development (GO:0061053)2.73902408
124striated muscle contraction (GO:0006941)2.73518285
125midgut development (GO:0007494)2.72989594
126negative regulation of striated muscle cell apoptotic process (GO:0010664)2.72075238
127negative regulation of chondrocyte differentiation (GO:0032331)2.71333938
128thalamus development (GO:0021794)2.71322416
129somatic stem cell division (GO:0048103)2.71154691
130regulation of hippo signaling (GO:0035330)2.70450998
131convergent extension (GO:0060026)2.70278039
132eye photoreceptor cell differentiation (GO:0001754)2.70054279
133photoreceptor cell differentiation (GO:0046530)2.70054279
134mesenchyme morphogenesis (GO:0072132)2.69609334
135cell surface receptor signaling pathway involved in heart development (GO:0061311)2.69571719
136basement membrane organization (GO:0071711)2.68856556
137heart trabecula morphogenesis (GO:0061384)2.67751599
138neuronal ion channel clustering (GO:0045161)2.67624641
139fatty acid transmembrane transport (GO:1902001)2.67581611
140polarized epithelial cell differentiation (GO:0030859)2.67370987
141left/right pattern formation (GO:0060972)2.66951501
142regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.65084670
143regulation of mesenchymal cell apoptotic process (GO:2001053)2.64068959
144negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.63628687
145axon development (GO:0061564)2.63405981
146G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.62592611
147growth hormone secretion (GO:0030252)2.62539650
148negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.62372178
149cell migration involved in heart development (GO:0060973)2.62314092
150glial cell differentiation (GO:0010001)2.62155825
151atrial septum morphogenesis (GO:0060413)2.61856720
152insulin-like growth factor receptor signaling pathway (GO:0048009)2.60610985
153neuron recognition (GO:0008038)2.60174736
154regulation of skeletal muscle contraction (GO:0014819)2.60064125
155heparan sulfate proteoglycan metabolic process (GO:0030201)2.59842353
156cardiac muscle cell action potential involved in contraction (GO:0086002)2.59797087
157embryonic foregut morphogenesis (GO:0048617)2.59054674
158lung-associated mesenchyme development (GO:0060484)2.59023606
159axon extension (GO:0048675)2.58764873
160innervation (GO:0060384)2.58715662
161cell migration involved in sprouting angiogenesis (GO:0002042)2.58287162
162notochord development (GO:0030903)2.58277272
163heart valve formation (GO:0003188)2.58235687
164response to auditory stimulus (GO:0010996)2.58125809
165Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.58123829
166apoptotic process involved in morphogenesis (GO:0060561)2.57528348
167regulation of sarcomere organization (GO:0060297)2.57410097
168negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.57309180
169lysine metabolic process (GO:0006553)2.57017878
170lysine catabolic process (GO:0006554)2.57017878
171dorsal/ventral neural tube patterning (GO:0021904)2.56462597
172negative regulation of glial cell differentiation (GO:0045686)2.56170107
173glomerulus development (GO:0032835)2.55678933
174positive regulation of astrocyte differentiation (GO:0048711)2.55517082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.77266362
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.98972705
3* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.94761613
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.87365374
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.83406319
6* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.76449545
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.68539373
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63888857
9CLOCK_20551151_ChIP-Seq_293T_Human2.51242403
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.42706863
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.34728722
12* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33449057
13* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.27312836
14* CBX2_27304074_Chip-Seq_ESCs_Mouse2.22657375
15* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22438266
16ZNF263_19887448_ChIP-Seq_K562_Human2.21281564
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18872713
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16035854
19TBX20_22080862_ChIP-Seq_HEART_Mouse2.07360066
20TBX20_22328084_ChIP-Seq_HEART_Mouse2.07360066
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01646973
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01646512
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.00116262
24ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.92086424
25* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.91312457
26EZH2_22144423_ChIP-Seq_EOC_Human1.87987397
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86360472
28* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.80129245
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.77189856
30* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.75681959
31* TP53_20018659_ChIP-ChIP_R1E_Mouse1.75594335
32* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.72927629
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.71581744
34* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69385021
35* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69385021
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69105066
37* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.67825875
38* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67483523
39* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67372843
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67072353
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.65778659
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63593185
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.63468757
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.60876743
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58448677
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57721592
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55532865
48* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54356346
49* EED_16625203_ChIP-ChIP_MESCs_Mouse1.54025444
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52705441
51* ISL1_27105846_Chip-Seq_CPCs_Mouse1.52248724
52KDM2B_26808549_Chip-Seq_K562_Human1.51799345
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51719585
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51250857
55* EZH2_27304074_Chip-Seq_ESCs_Mouse1.48063425
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46356200
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43479098
58AR_21572438_ChIP-Seq_LNCaP_Human1.42328344
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.40006520
60POU5F1_16518401_ChIP-PET_MESCs_Mouse1.38388743
61* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37962953
62* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35969624
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35264409
64* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35188018
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.33575926
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33010721
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32921975
68* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.32530351
69* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32480759
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31851344
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30436707
72LXR_22292898_ChIP-Seq_THP-1_Human1.30143636
73* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.30002185
74* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.29894986
75* RING1B_27294783_Chip-Seq_ESCs_Mouse1.29164554
76RNF2_27304074_Chip-Seq_NSC_Mouse1.28327453
77KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.27969982
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.27969982
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.27969982
80KDM2B_26808549_Chip-Seq_DND41_Human1.27812390
81* RING1B_27294783_Chip-Seq_NPCs_Mouse1.26353985
82NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.24902281
83* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.24689474
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24655212
85* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22687441
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.22236935
87DROSHA_22980978_ChIP-Seq_HELA_Human1.21727626
88* CTCF_27219007_Chip-Seq_Bcells_Human1.21553960
89* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21506562
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21102091
91* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20438121
92RACK7_27058665_Chip-Seq_MCF-7_Human1.20181628
93* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19615160
94PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18915071
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18032828
96* RNF2_27304074_Chip-Seq_ESCs_Mouse1.16465995
97* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.16322779
98* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15589227
99* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14200821
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14089752
101* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12845995
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12620430
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11642042
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10502464
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10164916
106SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09340314
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09110983
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09020542
109POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08707153
110RUNX1_27514584_Chip-Seq_MCF-7_Human1.07251661
111KDM2B_26808549_Chip-Seq_JURKAT_Human1.07170136
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06353001
113GBX2_23144817_ChIP-Seq_PC3_Human1.05975703
114* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03714553
115TP53_23651856_ChIP-Seq_MEFs_Mouse1.03141106
116* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02419837
117REST_21632747_ChIP-Seq_MESCs_Mouse1.02138130
118STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01799452
119ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01712845
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01556039
121* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00851864
122NANOG_21062744_ChIP-ChIP_HESCs_Human0.99744292
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99574855
124* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99563302
125TP63_19390658_ChIP-ChIP_HaCaT_Human0.99369029
126EZH2_27294783_Chip-Seq_ESCs_Mouse0.98871507
127* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98870640
128CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98672593
129CJUN_26792858_Chip-Seq_BT549_Human0.98236991
130CREB1_26743006_Chip-Seq_LNCaP_Human0.98156699
131LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94213826
132CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92917441
133CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92282762
134* SMAD3_21741376_ChIP-Seq_EPCs_Human0.91831641
135* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.89262087
136* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.88571676
137* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87103789
138* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86716286
139* SMAD3_21741376_ChIP-Seq_HESCs_Human0.83980496
140AHR_22903824_ChIP-Seq_MCF-7_Human0.83662889
141* TP53_18474530_ChIP-ChIP_U2OS_Human0.82919389
142CDX2_20551321_ChIP-Seq_CACO-2_Human0.82584356
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.82417132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology4.71212112
2MP0005377_hearing/vestibular/ear_phenot4.71212112
3MP0002837_dystrophic_cardiac_calcinosis4.21102411
4MP0004084_abnormal_cardiac_muscle4.15089380
5MP0003136_yellow_coat_color4.13447449
6MP0008438_abnormal_cutaneous_collagen3.76704765
7MP0000751_myopathy3.64556317
8MP0004215_abnormal_myocardial_fiber2.92608475
9MP0002102_abnormal_ear_morphology2.82175321
10MP0003705_abnormal_hypodermis_morpholog2.72895858
11MP0005330_cardiomyopathy2.61114018
12MP0003283_abnormal_digestive_organ2.47846484
13MP0004036_abnormal_muscle_relaxation2.45991940
14MP0003646_muscle_fatigue2.37648055
15MP0005275_abnormal_skin_tensile2.35039093
16MP0005623_abnormal_meninges_morphology2.34901277
17MP0004272_abnormal_basement_membrane2.25323577
18MP0001958_emphysema2.24735371
19MP0005248_abnormal_Harderian_gland2.22560244
20MP0003137_abnormal_impulse_conducting2.21622035
21MP0004885_abnormal_endolymph2.20650336
22MP0004087_abnormal_muscle_fiber2.13914654
23MP0005503_abnormal_tendon_morphology2.11349544
24MP0010630_abnormal_cardiac_muscle2.06649514
25MP0000750_abnormal_muscle_regeneration2.06640475
26MP0006138_congestive_heart_failure2.05465829
27MP0010030_abnormal_orbit_morphology1.98151296
28MP0002972_abnormal_cardiac_muscle1.97082872
29* MP0000778_abnormal_nervous_system1.93425802
30MP0001544_abnormal_cardiovascular_syste1.89927763
31MP0005385_cardiovascular_system_phenoty1.89927763
32MP0000749_muscle_degeneration1.89161581
33MP0004233_abnormal_muscle_weight1.88855496
34MP0003279_aneurysm1.88365835
35MP0004858_abnormal_nervous_system1.88232534
36MP0008775_abnormal_heart_ventricle1.85313498
37MP0002277_abnormal_respiratory_mucosa1.84531019
38MP0009053_abnormal_anal_canal1.73463038
39MP0005620_abnormal_muscle_contractility1.72960437
40MP0002234_abnormal_pharynx_morphology1.69857537
41MP0000579_abnormal_nail_morphology1.62716664
42* MP0000026_abnormal_inner_ear1.61403357
43MP0002282_abnormal_trachea_morphology1.53783156
44MP0002108_abnormal_muscle_morphology1.53208156
45MP0003938_abnormal_ear_development1.51176490
46MP0002269_muscular_atrophy1.48397091
47MP0002106_abnormal_muscle_physiology1.48259495
48MP0002249_abnormal_larynx_morphology1.45625542
49MP0000537_abnormal_urethra_morphology1.45501455
50MP0003828_pulmonary_edema1.43811725
51MP0004085_abnormal_heartbeat1.42507322
52MP0002822_catalepsy1.42405479
53MP0004742_abnormal_vestibular_system1.42249697
54MP0003115_abnormal_respiratory_system1.41573470
55MP0000534_abnormal_ureter_morphology1.41420369
56MP0003567_abnormal_fetal_cardiomyocyte1.39981984
57MP0005369_muscle_phenotype1.39060712
58MP0003566_abnormal_cell_adhesion1.36116851
59MP0003942_abnormal_urinary_system1.33555527
60MP0004484_altered_response_of1.32661227
61MP0000759_abnormal_skeletal_muscle1.30761265
62* MP0000955_abnormal_spinal_cord1.30313080
63MP0002092_abnormal_eye_morphology1.29088909
64MP0010368_abnormal_lymphatic_system1.28791092
65MP0004145_abnormal_muscle_electrophysio1.27443143
66MP0000733_abnormal_muscle_development1.27173907
67MP0001502_abnormal_circadian_rhythm1.23675517
68MP0003634_abnormal_glial_cell1.23275552
69MP0004130_abnormal_muscle_cell1.21798638
70MP0002653_abnormal_ependyma_morphology1.21241133
71MP0003122_maternal_imprinting1.20794344
72MP0002127_abnormal_cardiovascular_syste1.19523874
73MP0000428_abnormal_craniofacial_morphol1.18507437
74MP0005508_abnormal_skeleton_morphology1.17511878
75MP0001984_abnormal_olfaction1.16772960
76MP0003385_abnormal_body_wall1.16746207
77MP0003941_abnormal_skin_development1.15913769
78MP0004859_abnormal_synaptic_plasticity1.14637130
79MP0000266_abnormal_heart_morphology1.14482319
80MP0001346_abnormal_lacrimal_gland1.14423309
81MP0002928_abnormal_bile_duct1.13871961
82MP0008961_abnormal_basal_metabolism1.13797397
83MP0003329_amyloid_beta_deposits1.13519093
84MP0005666_abnormal_adipose_tissue1.13214828
85MP0002932_abnormal_joint_morphology1.13072196
86MP0001286_abnormal_eye_development1.12570110
87MP0003937_abnormal_limbs/digits/tail_de1.12417556
88MP0002909_abnormal_adrenal_gland1.10349809
89MP0000462_abnormal_digestive_system1.09870034
90MP0000767_abnormal_smooth_muscle1.07504867
91MP0000467_abnormal_esophagus_morphology1.06814144
92MP0000049_abnormal_middle_ear1.06244666
93MP0005409_darkened_coat_color1.06229455
94MP0009379_abnormal_foot_pigmentation1.05072989
95MP0004133_heterotaxia1.04965464
96MP0000747_muscle_weakness1.01524530
97MP0002233_abnormal_nose_morphology1.01103386
98MP0003861_abnormal_nervous_system1.00451028
99MP0005076_abnormal_cell_differentiation0.99048176
100MP0009384_cardiac_valve_regurgitation0.98079526
101MP0000566_synostosis0.97444281
102MP0003755_abnormal_palate_morphology0.95200515
103MP0002925_abnormal_cardiovascular_devel0.94976775
104MP0000762_abnormal_tongue_morphology0.94931343
105MP0000631_abnormal_neuroendocrine_gland0.94764112
106MP0003935_abnormal_craniofacial_develop0.94300013
107MP0002184_abnormal_innervation0.93879713
108MP0002128_abnormal_blood_circulation0.93365858
109MP0001485_abnormal_pinna_reflex0.92378571
110MP0006054_spinal_hemorrhage0.88808448
111MP0002638_abnormal_pupillary_reflex0.87383381
112MP0003119_abnormal_digestive_system0.86176941
113MP0003091_abnormal_cell_migration0.85665479
114MP0005423_abnormal_somatic_nervous0.84919856
115MP0001293_anophthalmia0.84503531
116MP0001963_abnormal_hearing_physiology0.84137374
117MP0003880_abnormal_central_pattern0.83936652
118MP0005670_abnormal_white_adipose0.83904584
119MP0000569_abnormal_digit_pigmentation0.83902181
120MP0003221_abnormal_cardiomyocyte_apopto0.83789235
121MP0005391_vision/eye_phenotype0.83380332
122MP0000383_abnormal_hair_follicle0.82970013
123MP0002332_abnormal_exercise_endurance0.82713760
124MP0002751_abnormal_autonomic_nervous0.82575314
125MP0009250_abnormal_appendicular_skeleto0.82350604
126MP0003950_abnormal_plasma_membrane0.81639579
127MP0002697_abnormal_eye_size0.81313687
128MP0000432_abnormal_head_morphology0.81072604
129MP0001879_abnormal_lymphatic_vessel0.80727110
130MP0001849_ear_inflammation0.79765143
131MP0002089_abnormal_postnatal_growth/wei0.79647612
132* MP0002152_abnormal_brain_morphology0.79595253
133MP0002116_abnormal_craniofacial_bone0.78582099
134MP0000343_altered_response_to0.78391534
135MP0004185_abnormal_adipocyte_glucose0.77842662
136MP0005257_abnormal_intraocular_pressure0.77702240
137MP0002882_abnormal_neuron_morphology0.76627718
138MP0002132_abnormal_respiratory_system0.76278087
139MP0005375_adipose_tissue_phenotype0.76269328
140MP0003984_embryonic_growth_retardation0.75178357
141MP0002088_abnormal_embryonic_growth/wei0.74378268
142MP0002063_abnormal_learning/memory/cond0.74098851
143MP0002295_abnormal_pulmonary_circulatio0.74028116
144MP0001299_abnormal_eye_distance/0.73645706
145MP0002111_abnormal_tail_morphology0.73601862
146MP0002084_abnormal_developmental_patter0.73153498
147MP0001614_abnormal_blood_vessel0.73040289
148MP0009780_abnormal_chondrocyte_physiolo0.73022721
149MP0000163_abnormal_cartilage_morphology0.72603327
150MP0002896_abnormal_bone_mineralization0.72424205
151MP0003632_abnormal_nervous_system0.72149982
152MP0001529_abnormal_vocalization0.71800537
153MP0000613_abnormal_salivary_gland0.70713166
154MP0003635_abnormal_synaptic_transmissio0.70503162
155MP0005197_abnormal_uvea_morphology0.69935298
156* MP0002081_perinatal_lethality0.68389634
157MP0005193_abnormal_anterior_eye0.67789753
158MP0005171_absent_coat_pigmentation0.67536129
159MP0002572_abnormal_emotion/affect_behav0.67204057
160MP0002114_abnormal_axial_skeleton0.62366103

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.52828542
2Partial duplication of thumb phalanx (HP:0009944)5.13682690
3Partial duplication of the phalanx of hand (HP:0009999)4.98850952
4Ventricular tachycardia (HP:0004756)4.63117163
5Aplasia involving bones of the upper limbs (HP:0009823)4.33961727
6Aplasia of the phalanges of the hand (HP:0009802)4.33961727
7Aplasia involving bones of the extremities (HP:0009825)4.33961727
8Increased connective tissue (HP:0009025)4.31397441
9Ankle contracture (HP:0006466)4.25472884
10Muscle fiber splitting (HP:0003555)4.15539017
11Atrial fibrillation (HP:0005110)3.99410584
12Broad metatarsal (HP:0001783)3.98126727
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.96066559
14Right ventricular cardiomyopathy (HP:0011663)3.82249973
15Protrusio acetabuli (HP:0003179)3.81030580
16Primary atrial arrhythmia (HP:0001692)3.78991807
17Supraventricular arrhythmia (HP:0005115)3.63861859
18Supraventricular tachycardia (HP:0004755)3.61806104
19Lipoatrophy (HP:0100578)3.57709183
20Abnormal respiratory motile cilium physiology (HP:0012261)3.49462886
21Abnormal ciliary motility (HP:0012262)3.49393371
22Abnormality of the calf musculature (HP:0001430)3.44814150
23Abnormal respiratory epithelium morphology (HP:0012253)3.43323675
24Abnormal respiratory motile cilium morphology (HP:0005938)3.43323675
25Cerebral aneurysm (HP:0004944)3.34809142
26Premature rupture of membranes (HP:0001788)3.33124885
27Shallow orbits (HP:0000586)3.28202896
28Exercise-induced muscle cramps (HP:0003710)3.28157457
29Dynein arm defect of respiratory motile cilia (HP:0012255)3.25685404
30Absent/shortened dynein arms (HP:0200106)3.25685404
31Calf muscle hypertrophy (HP:0008981)3.18298562
32Type 1 muscle fiber predominance (HP:0003803)3.10805349
33Split foot (HP:0001839)3.06859688
34Hyporeflexia of lower limbs (HP:0002600)3.05151643
35Syncope (HP:0001279)2.97852815
36Abnormality of the left ventricular outflow tract (HP:0011103)2.96806365
37Subaortic stenosis (HP:0001682)2.96806365
38Rhinitis (HP:0012384)2.93452431
39Abnormality of the 4th metacarpal (HP:0010012)2.91998620
40Prolonged QT interval (HP:0001657)2.87106210
41Lymphangioma (HP:0100764)2.84842772
42Increased variability in muscle fiber diameter (HP:0003557)2.84568970
43Mildly elevated creatine phosphokinase (HP:0008180)2.81948830
44Ventricular arrhythmia (HP:0004308)2.76019727
45Aortic dissection (HP:0002647)2.75820978
46Bundle branch block (HP:0011710)2.74845805
47Muscle hypertrophy of the lower extremities (HP:0008968)2.72135148
48Exercise-induced myalgia (HP:0003738)2.64290099
49Dilated cardiomyopathy (HP:0001644)2.59296156
50Esophageal atresia (HP:0002032)2.58639921
51Abnormality of the diencephalon (HP:0010662)2.57900066
52Glomerulonephritis (HP:0000099)2.57013977
53Asymmetric septal hypertrophy (HP:0001670)2.56832707
54Difficulty running (HP:0009046)2.55502779
55Ventricular fibrillation (HP:0001663)2.55299636
56Duplication of thumb phalanx (HP:0009942)2.51844936
57Renal duplication (HP:0000075)2.50703661
58Bladder diverticulum (HP:0000015)2.49902963
59Missing ribs (HP:0000921)2.48031344
60Anophthalmia (HP:0000528)2.47718333
61Myoglobinuria (HP:0002913)2.40158172
62Septo-optic dysplasia (HP:0100842)2.39737241
63Spinal rigidity (HP:0003306)2.38208249
64Coronal craniosynostosis (HP:0004440)2.37249222
65Abnormality of skeletal muscle fiber size (HP:0012084)2.35877296
66Maternal diabetes (HP:0009800)2.35406973
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.34218954
68Short 4th metacarpal (HP:0010044)2.34218954
69Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.33641067
70Myotonia (HP:0002486)2.32513015
71Atrioventricular block (HP:0001678)2.32438509
72Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.31544106
73Mixed hearing impairment (HP:0000410)2.28893530
74Palpitations (HP:0001962)2.28879010
75Difficulty climbing stairs (HP:0003551)2.28413205
76EMG: myopathic abnormalities (HP:0003458)2.26656865
77Mitral valve prolapse (HP:0001634)2.26194882
78Concave nail (HP:0001598)2.25557098
79Wide anterior fontanel (HP:0000260)2.23049068
80Heart block (HP:0012722)2.22937765
81Aneurysm (HP:0002617)2.21397116
82Alacrima (HP:0000522)2.21215691
83Fragile skin (HP:0001030)2.20901667
84Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.19809025
85Vertebral hypoplasia (HP:0008417)2.19809025
86Abnormal atrioventricular conduction (HP:0005150)2.18807347
87Vascular tortuosity (HP:0004948)2.15257277
88Soft skin (HP:0000977)2.13297366
89Arterial tortuosity (HP:0005116)2.11193414
90Nephritis (HP:0000123)2.09793061
91Aortic aneurysm (HP:0004942)2.08238453
92Thin ribs (HP:0000883)2.06990436
93Wrist flexion contracture (HP:0001239)2.06609195
94Atrophic scars (HP:0001075)2.04698223
95Abnormality of the parietal bone (HP:0002696)2.03933003
96Oligodactyly (hands) (HP:0001180)2.03377227
97Neonatal short-limb short stature (HP:0008921)2.03058835
98Abnormality of permanent molar morphology (HP:0011071)2.01575207
99Abnormality of the dental root (HP:0006486)2.01575207
100Taurodontia (HP:0000679)2.01575207
101Gastrointestinal atresia (HP:0002589)2.01497407
102Abnormality of molar morphology (HP:0011070)1.99042526
103Abnormality of molar (HP:0011077)1.99042526
104Aplasia of the musculature (HP:0100854)1.98688159
105Pulmonary artery stenosis (HP:0004415)1.98117544
106Hypoplastic ischia (HP:0003175)1.97212188
107Blue sclerae (HP:0000592)1.97201163
108Abnormality of incisor morphology (HP:0011063)1.96906092
109Synostosis involving the elbow (HP:0003938)1.96316780
110Humeroradial synostosis (HP:0003041)1.96316780
111Hyperacusis (HP:0010780)1.95904992
112Vertebral clefting (HP:0008428)1.94754202
113Generalized amyotrophy (HP:0003700)1.92100795
114Broad face (HP:0000283)1.90355816
115Abnormal EKG (HP:0003115)1.89131134
116Bronchomalacia (HP:0002780)1.88926076
117Limb-girdle muscle weakness (HP:0003325)1.88831971
118Follicular hyperkeratosis (HP:0007502)1.88648946
119Scapular winging (HP:0003691)1.87156548
12011 pairs of ribs (HP:0000878)1.85886583
121Midline defect of the nose (HP:0004122)1.84090963
122Recurrent corneal erosions (HP:0000495)1.83714239
123Bifid scrotum (HP:0000048)1.83074147
124Broad hallux (HP:0010055)1.83003425
125Supernumerary ribs (HP:0005815)1.82221003
126Limb-girdle muscle atrophy (HP:0003797)1.82092849
127Hip contracture (HP:0003273)1.80603899
128Hypoventilation (HP:0002791)1.79010995
129Abnormality of the dental pulp (HP:0006479)1.78118183
130Abnormality of the right ventricle (HP:0001707)1.77044570
131Nasal polyposis (HP:0100582)1.76799665
132Abnormal number of incisors (HP:0011064)1.76125071
133Anal stenosis (HP:0002025)1.75867498
134Mesangial abnormality (HP:0001966)1.74891045
135Atelectasis (HP:0100750)1.74800428
136Preaxial foot polydactyly (HP:0001841)1.74201671
137Rectal prolapse (HP:0002035)1.73388994
138Anterior segment dysgenesis (HP:0007700)1.73352283
139Neoplasm of the heart (HP:0100544)1.73208112
140Hyperextensible skin (HP:0000974)1.73060699
141Turricephaly (HP:0000262)1.72821750
142Tracheomalacia (HP:0002779)1.72480378
143Synostosis of carpal bones (HP:0005048)1.72177753
144Hemivertebrae (HP:0002937)1.71766506
145Type II lissencephaly (HP:0007260)1.70036561
146Ketoacidosis (HP:0001993)1.69662129
147Abnormality of the ischium (HP:0003174)1.69542361
148Trigonocephaly (HP:0000243)1.68612207
149Dilatation of the ascending aorta (HP:0005111)1.68423367
150Synostosis involving bones of the lower limbs (HP:0009138)1.68413587
151Synostosis involving bones of the feet (HP:0009140)1.68413587
152Genu recurvatum (HP:0002816)1.68389410
153Arnold-Chiari malformation (HP:0002308)1.68269796
154Visceral angiomatosis (HP:0100761)1.68056340
155Narrow nasal bridge (HP:0000446)1.67858711
156Enlarged penis (HP:0000040)1.67727316
157Fibular hypoplasia (HP:0003038)1.67319102
158Exostoses (HP:0100777)1.66375253
159Tarsal synostosis (HP:0008368)1.65276252
160Bilateral microphthalmos (HP:0007633)1.65093064
161Nasolacrimal duct obstruction (HP:0000579)1.64287390
162Abnormality of the pubic bones (HP:0003172)1.62667245
163Abnormality of the incisor (HP:0000676)1.62460636
164Chronic bronchitis (HP:0004469)1.62405332
165Broad toe (HP:0001837)1.61914400
166Overriding aorta (HP:0002623)1.61502467
167Pheochromocytoma (HP:0002666)1.59976600
168Skull defect (HP:0001362)1.59594544
169Hypoplasia of the ulna (HP:0003022)1.59535818
170Venous insufficiency (HP:0005293)1.58696199
171Prenatal maternal abnormality (HP:0002686)1.57799104
172Cerebellar dysplasia (HP:0007033)1.56903328
173Congenital glaucoma (HP:0001087)1.56677885
174Flat cornea (HP:0007720)1.56496163
175Vertebral arch anomaly (HP:0008438)1.56387740
176Heterochromia iridis (HP:0001100)1.55989646
177Aplasia/Hypoplasia of the fibula (HP:0006492)1.55605829
178Fibroma (HP:0010614)1.55438892
179Mesomelia (HP:0003027)1.55168234
180Hamartoma of the eye (HP:0010568)1.54766766
181Distal lower limb muscle weakness (HP:0009053)1.54742530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.87312216
2PNCK6.10544435
3TTN4.44107519
4TRIB34.07547982
5PKN23.38708475
6LMTK22.73809429
7EPHB22.71874849
8PDGFRA2.63088814
9MARK12.62921093
10WEE12.51501157
11TSSK62.50524444
12NEK12.37314135
13DMPK2.34636607
14MYLK2.33102681
15RIPK12.29854171
16PHKG22.28365201
17PHKG12.28365201
18SIK12.12438585
19ICK2.00790299
20DDR21.99033834
21CASK1.96471639
22LATS11.96365902
23PDK41.85901141
24PDK31.85901141
25PAK31.82522680
26NTRK31.72913251
27BCKDK1.72255182
28LATS21.69599764
29TIE11.65978585
30KSR11.55598408
31ILK1.40059162
32TGFBR21.37658541
33PTK61.36769970
34PAK41.34176542
35MAP3K101.33279351
36MOS1.26758513
37TYRO31.26647033
38EPHA31.23336003
39ROCK11.22759072
40FER1.17518399
41TNIK1.15858314
42STK38L1.14306022
43VRK11.10761504
44OBSCN1.10299165
45CDK121.09832750
46ERBB21.08909050
47MTOR1.08209578
48CDC42BPA1.07823045
49FGFR11.04768800
50CDK31.04293223
51ROCK21.03862614
52BMX1.00785236
53EPHB11.00721653
54EEF2K1.00037427
55STK240.98948439
56PAK20.95140230
57PRKD10.94953845
58WNK40.94097491
59DYRK20.94094975
60PDK20.92339240
61STK380.90622701
62IRAK10.89060653
63PIK3CA0.86118931
64LRRK20.81078962
65PDGFRB0.79570955
66DYRK1B0.78284608
67CAMK1D0.76881936
68PAK60.76320182
69PTK20.72194926
70ERN10.72092408
71PKN10.70215150
72KSR20.67660095
73PRKAA10.67416773
74MAP3K70.66277300
75FGFR40.64135581
76CAMK40.63305386
77AKT20.61985846
78MAP2K20.61181034
79UHMK10.61021725
80GSK3A0.60606331
81CAMK1G0.60186642
82CAMK2B0.60002386
83SMG10.59498835
84TGFBR10.54965971
85FGFR20.54439454
86MAP3K20.53987472
87RPS6KL10.53855164
88RPS6KC10.53855164
89FGFR30.53706759
90NEK60.53367141
91MAPKAPK30.51609569
92RET0.50761707
93CDK80.50188752
94ERBB40.50089157
95MAPKAPK50.49975666
96WNK10.48498661
97MAP3K40.48323248
98DYRK1A0.46978317
99MAP2K40.46456269
100MAP3K90.45493419
101CSNK1G20.45034344
102CAMK2D0.44133533
103NTRK10.43329130
104DAPK30.43228702
105PRKCG0.42720016
106MARK20.42071195
107PRKAA20.41513246
108RPS6KA10.41009423
109RPS6KA60.37996779
110MAP2K70.37190441
111GRK70.36723463
112NEK90.36597732
113PRKACB0.36055406
114MATK0.34593586
115STK40.33814934
116SRC0.33325888
117PRKCH0.33132080
118NTRK20.32936916
119PRKD30.32833068
120TESK10.32374719
121PINK10.31876461
122STK30.30729653
123SGK2230.30554661
124SGK4940.30554661
125CDK50.29800358
126ARAF0.29416541
127ALK0.28772953
128PRKD20.28718558
129PRKACG0.28329270
130PTK2B0.27152166
131MKNK10.27021053
132MAPK100.26831269
133PRKCZ0.26705578
134CDK150.26560695
135YES10.25638269
136MET0.25501136
137EPHA20.25395889
138RPS6KA20.25299865
139EIF2AK20.24919285
140MAP2K10.24259745
141ADRBK10.23510466
142CDK11A0.23399527
143MAPK90.22791413
144CDK60.21928506
145DYRK30.21636433

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.00442168
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.99718198
3Dilated cardiomyopathy_Homo sapiens_hsa054143.21479783
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.04926796
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.63924904
6Cardiac muscle contraction_Homo sapiens_hsa042602.41818852
7Basal cell carcinoma_Homo sapiens_hsa052172.38177311
8Propanoate metabolism_Homo sapiens_hsa006402.30747089
9ECM-receptor interaction_Homo sapiens_hsa045122.28332319
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20857337
11Fatty acid degradation_Homo sapiens_hsa000712.12412166
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.03725034
13Hedgehog signaling pathway_Homo sapiens_hsa043402.00753712
14Cocaine addiction_Homo sapiens_hsa050302.00384699
15Fatty acid metabolism_Homo sapiens_hsa012121.92494436
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86952712
17Notch signaling pathway_Homo sapiens_hsa043301.85883304
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.85760069
19Focal adhesion_Homo sapiens_hsa045101.83397275
20Viral myocarditis_Homo sapiens_hsa054161.82468046
21Carbon metabolism_Homo sapiens_hsa012001.77931185
22Hippo signaling pathway_Homo sapiens_hsa043901.61174104
23Lysine degradation_Homo sapiens_hsa003101.55438481
24Protein digestion and absorption_Homo sapiens_hsa049741.53656534
25Adherens junction_Homo sapiens_hsa045201.51634634
26Proteoglycans in cancer_Homo sapiens_hsa052051.41811994
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40295422
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36066335
29Butanoate metabolism_Homo sapiens_hsa006501.34715429
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27728304
31Pyruvate metabolism_Homo sapiens_hsa006201.27684232
32PPAR signaling pathway_Homo sapiens_hsa033201.25820465
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22474678
34Biosynthesis of amino acids_Homo sapiens_hsa012301.18853881
35MicroRNAs in cancer_Homo sapiens_hsa052061.11218681
36cAMP signaling pathway_Homo sapiens_hsa040241.10594231
37Circadian entrainment_Homo sapiens_hsa047131.10378402
38Tight junction_Homo sapiens_hsa045301.10140751
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.09714428
40Choline metabolism in cancer_Homo sapiens_hsa052311.09049388
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.06293703
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04728411
43Small cell lung cancer_Homo sapiens_hsa052221.04194714
44ErbB signaling pathway_Homo sapiens_hsa040121.00410410
45Bladder cancer_Homo sapiens_hsa052191.00149062
46Amoebiasis_Homo sapiens_hsa051460.97561593
47Cholinergic synapse_Homo sapiens_hsa047250.95880945
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94822788
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93368525
50Glutamatergic synapse_Homo sapiens_hsa047240.93293146
51Melanogenesis_Homo sapiens_hsa049160.92494891
52Insulin resistance_Homo sapiens_hsa049310.91655051
53Amphetamine addiction_Homo sapiens_hsa050310.90865796
54AMPK signaling pathway_Homo sapiens_hsa041520.89298538
55Tryptophan metabolism_Homo sapiens_hsa003800.88116641
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88054992
57Parkinsons disease_Homo sapiens_hsa050120.86900439
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86355774
59Dorso-ventral axis formation_Homo sapiens_hsa043200.85500197
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85402004
61Insulin secretion_Homo sapiens_hsa049110.84993468
62TGF-beta signaling pathway_Homo sapiens_hsa043500.84948876
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84284622
64Wnt signaling pathway_Homo sapiens_hsa043100.83808785
65Arginine and proline metabolism_Homo sapiens_hsa003300.82737756
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82679502
67GABAergic synapse_Homo sapiens_hsa047270.82606634
68Histidine metabolism_Homo sapiens_hsa003400.82595886
69Arginine biosynthesis_Homo sapiens_hsa002200.81584739
70* Axon guidance_Homo sapiens_hsa043600.80533343
71GnRH signaling pathway_Homo sapiens_hsa049120.79610131
72Dopaminergic synapse_Homo sapiens_hsa047280.79353355
73Fatty acid biosynthesis_Homo sapiens_hsa000610.79012690
74Nitrogen metabolism_Homo sapiens_hsa009100.78897100
75MAPK signaling pathway_Homo sapiens_hsa040100.78054118
76Pathways in cancer_Homo sapiens_hsa052000.77078551
77Insulin signaling pathway_Homo sapiens_hsa049100.76692099
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75719303
79Gap junction_Homo sapiens_hsa045400.75366499
80Prostate cancer_Homo sapiens_hsa052150.73146348
81Circadian rhythm_Homo sapiens_hsa047100.72720835
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70609730
83Nicotine addiction_Homo sapiens_hsa050330.70458604
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.70359943
85Endometrial cancer_Homo sapiens_hsa052130.69547395
86Chronic myeloid leukemia_Homo sapiens_hsa052200.67553856
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67151885
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66376608
89Glucagon signaling pathway_Homo sapiens_hsa049220.66246123
90mTOR signaling pathway_Homo sapiens_hsa041500.64193438
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.62467348
92HIF-1 signaling pathway_Homo sapiens_hsa040660.62127064
93Renal cell carcinoma_Homo sapiens_hsa052110.62048525
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60859412
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60679606
96Bile secretion_Homo sapiens_hsa049760.59929311
97Phenylalanine metabolism_Homo sapiens_hsa003600.59171560
98Melanoma_Homo sapiens_hsa052180.57915415
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57182332
100Morphine addiction_Homo sapiens_hsa050320.55626200
101Ras signaling pathway_Homo sapiens_hsa040140.55017110
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54978567
103Prolactin signaling pathway_Homo sapiens_hsa049170.54914305
104Estrogen signaling pathway_Homo sapiens_hsa049150.54504077
105Rap1 signaling pathway_Homo sapiens_hsa040150.54427691
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.50577364
107Colorectal cancer_Homo sapiens_hsa052100.50411572
108Starch and sucrose metabolism_Homo sapiens_hsa005000.49945270
109Salivary secretion_Homo sapiens_hsa049700.49658935
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49595948
111Alzheimers disease_Homo sapiens_hsa050100.49082680
112Ovarian steroidogenesis_Homo sapiens_hsa049130.48786090
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47535624
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47243243
115Glioma_Homo sapiens_hsa052140.47169895
116Fatty acid elongation_Homo sapiens_hsa000620.46773932
117Calcium signaling pathway_Homo sapiens_hsa040200.46532736
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46336729
119Alcoholism_Homo sapiens_hsa050340.45227041
120Huntingtons disease_Homo sapiens_hsa050160.44548681
121Long-term depression_Homo sapiens_hsa047300.44510624
122Oxidative phosphorylation_Homo sapiens_hsa001900.42959521
123Thyroid hormone synthesis_Homo sapiens_hsa049180.42933015
124VEGF signaling pathway_Homo sapiens_hsa043700.42768722
125beta-Alanine metabolism_Homo sapiens_hsa004100.42683469
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42123017
127Gastric acid secretion_Homo sapiens_hsa049710.42008914
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.40883599
129Renin secretion_Homo sapiens_hsa049240.40265927
130Prion diseases_Homo sapiens_hsa050200.38919435
131Taste transduction_Homo sapiens_hsa047420.38468074
132Type II diabetes mellitus_Homo sapiens_hsa049300.35650339
133Oxytocin signaling pathway_Homo sapiens_hsa049210.35457307
134HTLV-I infection_Homo sapiens_hsa051660.34905487
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34868906
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34412305
137Pancreatic cancer_Homo sapiens_hsa052120.33964655

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »