NTN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)9.86027319
2negative regulation of cell aging (GO:0090344)9.59344509
3regulation of synapse structural plasticity (GO:0051823)8.79856646
4protein carboxylation (GO:0018214)8.78926524
5peptidyl-glutamic acid carboxylation (GO:0017187)8.78926524
6DNA strand renaturation (GO:0000733)8.76764413
7mitotic cell cycle arrest (GO:0071850)8.75872408
8GDP-mannose metabolic process (GO:0019673)8.00317064
9cellular response to ATP (GO:0071318)7.97488720
10meiotic chromosome segregation (GO:0045132)7.28171448
11regulation of cytokine production involved in inflammatory response (GO:1900015)7.20711974
12transepithelial transport (GO:0070633)6.72636796
13adenosine receptor signaling pathway (GO:0001973)6.43768760
14lens fiber cell differentiation (GO:0070306)6.32109023
15detection of light stimulus involved in visual perception (GO:0050908)6.14755672
16detection of light stimulus involved in sensory perception (GO:0050962)6.14755672
17G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)6.13710001
18negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)6.08315407
19estrogen biosynthetic process (GO:0006703)5.42456093
20purinergic nucleotide receptor signaling pathway (GO:0035590)5.31632037
21semaphorin-plexin signaling pathway (GO:0071526)5.30303570
22positive regulation of heat generation (GO:0031652)5.20476997
23granulocyte differentiation (GO:0030851)5.12450452
24phosphatidylglycerol biosynthetic process (GO:0006655)4.49280150
25behavioral response to nicotine (GO:0035095)4.48270365
26regulation of phospholipid biosynthetic process (GO:0071071)4.46786839
27positive regulation of protein kinase C signaling (GO:0090037)4.43767431
28proline biosynthetic process (GO:0006561)4.41951312
29regulation of cell aging (GO:0090342)4.38865889
30negative regulation of interleukin-8 production (GO:0032717)4.32480713
31sulfur amino acid catabolic process (GO:0000098)4.22955631
32cell migration in hindbrain (GO:0021535)4.12678441
33response to ATP (GO:0033198)4.08827228
34type B pancreatic cell proliferation (GO:0044342)4.08806942
35cellular anion homeostasis (GO:0030002)4.05584602
36peptidyl-glutamic acid modification (GO:0018200)4.02845257
37sphingomyelin metabolic process (GO:0006684)4.02329394
38sensory perception of taste (GO:0050909)3.98965389
39sphingosine metabolic process (GO:0006670)3.98536691
40cardiolipin metabolic process (GO:0032048)3.88896794
41mannose metabolic process (GO:0006013)3.87617581
42purinergic receptor signaling pathway (GO:0035587)3.83560763
43negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.82641279
44folic acid metabolic process (GO:0046655)3.81687614
45regulation of heat generation (GO:0031650)3.79223680
46UV protection (GO:0009650)3.76638492
47phosphate ion homeostasis (GO:0055062)3.75749493
48trivalent inorganic anion homeostasis (GO:0072506)3.75749493
49phosphate ion transmembrane transport (GO:0035435)3.68874016
50rRNA methylation (GO:0031167)3.65275646
51DNA duplex unwinding (GO:0032508)3.64325056
52diol metabolic process (GO:0034311)3.61021096
53G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.60823854
54endocytic recycling (GO:0032456)3.58406917
55nucleotide-sugar biosynthetic process (GO:0009226)3.54032350
56peristalsis (GO:0030432)3.48908752
57mitochondrion distribution (GO:0048311)3.48623411
58grooming behavior (GO:0007625)3.45734769
59DNA geometric change (GO:0032392)3.45595845
60DNA replication checkpoint (GO:0000076)3.43009803
61sympathetic nervous system development (GO:0048485)3.34635160
62urinary tract smooth muscle contraction (GO:0014848)3.34539833
63proline metabolic process (GO:0006560)3.31461158
64adenine nucleotide transport (GO:0051503)3.27713659
65regulation of guanylate cyclase activity (GO:0031282)3.26717584
66DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.24526888
67neuromuscular synaptic transmission (GO:0007274)3.18614514
68cilium or flagellum-dependent cell motility (GO:0001539)3.18478573
69purine ribonucleotide transport (GO:0015868)3.18199503
70protein retention in ER lumen (GO:0006621)3.14421216
71planar cell polarity pathway involved in neural tube closure (GO:0090179)3.14165687
72rRNA modification (GO:0000154)3.12361490
73purine deoxyribonucleotide catabolic process (GO:0009155)3.09567124
74positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.07842304
75dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.06285396
76positive regulation of megakaryocyte differentiation (GO:0045654)3.04141103
77protein insertion into membrane (GO:0051205)3.03937232
78folic acid transport (GO:0015884)3.02031417
79heme transport (GO:0015886)3.01930582
80base-excision repair, AP site formation (GO:0006285)2.99948683
81positive regulation of TOR signaling (GO:0032008)2.99917327
82phosphatidylethanolamine biosynthetic process (GO:0006646)2.99253129
83type B pancreatic cell development (GO:0003323)2.98011929
84phosphate ion transport (GO:0006817)2.93587616
85DNA damage response, signal transduction resulting in transcription (GO:0042772)2.90575842
86melanin biosynthetic process (GO:0042438)2.85341074
87regulation of nuclear cell cycle DNA replication (GO:0033262)2.84317578
88iron coordination entity transport (GO:1901678)2.76603868
89positive regulation of axonogenesis (GO:0050772)2.75427551
90nucleoside transmembrane transport (GO:1901642)2.75391123
91protein import into peroxisome matrix (GO:0016558)2.75163131
92sphingoid metabolic process (GO:0046519)2.74548825
93regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74504266
94histone phosphorylation (GO:0016572)2.73588426
95regulation of interferon-beta biosynthetic process (GO:0045357)2.73240793
96sex determination (GO:0007530)2.71006797
97positive regulation of guanylate cyclase activity (GO:0031284)2.69563249
98regulation of protein kinase A signaling (GO:0010738)2.67847996
99N-terminal protein amino acid modification (GO:0031365)2.67077335
100regulation of meiosis (GO:0040020)2.66743262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human4.27484517
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.45567815
3TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.34777114
4LXR_22292898_ChIP-Seq_THP-1_Human3.07473415
5* P68_20966046_ChIP-Seq_HELA_Human2.95348611
6XRN2_22483619_ChIP-Seq_HELA_Human2.86177453
7CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.76941861
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.68604988
9ERG_21242973_ChIP-ChIP_JURKAT_Human2.54116924
10* MAF_26560356_Chip-Seq_TH2_Human2.41618793
11DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.31263849
12DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.30685714
13* E2F1_20622854_ChIP-Seq_HELA_Human2.29343501
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28786891
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23983263
16* RACK7_27058665_Chip-Seq_MCF-7_Human2.22601875
17MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.17038678
18CTCF_27219007_Chip-Seq_Bcells_Human2.13411248
19* BCOR_27268052_Chip-Seq_Bcells_Human2.12421343
20PHF8_20622854_ChIP-Seq_HELA_Human2.10799176
21* CTCF_27219007_Chip-Seq_ERYTHROID_Human2.08589390
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.06424234
23BCL6_27268052_Chip-Seq_Bcells_Human2.05741363
24MYC_22102868_ChIP-Seq_BL_Human2.05655247
25TET1_21451524_ChIP-Seq_MESCs_Mouse2.04585730
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.96875723
27* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.94799640
28* MAF_26560356_Chip-Seq_TH1_Human1.93213527
29* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90607478
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.89122050
31VDR_24763502_ChIP-Seq_THP-1_Human1.87733015
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85034977
33SMC4_20622854_ChIP-Seq_HELA_Human1.83569102
34RARA_24833708_ChIP-Seq_LIVER_Mouse1.83395732
35RXRA_24833708_ChIP-Seq_LIVER_Mouse1.81557723
36* RARB_24833708_ChIP-Seq_LIVER_Mouse1.81036454
37TP53_22127205_ChIP-Seq_IMR90_Human1.77519074
38KDM2B_26808549_Chip-Seq_DND41_Human1.77196405
39CTCF_21964334_Chip-Seq_Bcells_Human1.76694999
40* FOXP1_21924763_ChIP-Seq_HESCs_Human1.73644511
41SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.70322143
42* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70207951
43* SA1_27219007_Chip-Seq_ERYTHROID_Human1.70169583
44SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.70040759
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.67475417
46CTCF_20526341_ChIP-Seq_ESCs_Human1.61795364
47* UTX_26944678_Chip-Seq_JUKART_Human1.59470157
48* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.58128977
49* CREB1_26743006_Chip-Seq_LNCaP_Human1.56325129
50SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54895922
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.54276862
52* YY1_22570637_ChIP-Seq_MALME-3M_Human1.53834676
53CTCF_21964334_ChIP-Seq_BJAB-B_Human1.53149939
54CIITA_25753668_ChIP-Seq_RAJI_Human1.48697105
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46174282
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45835200
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45623485
58TCF7_22412390_ChIP-Seq_EML_Mouse1.43455312
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43193571
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40354572
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35529230
62ETS1_21867929_ChIP-Seq_TH2_Mouse1.33193862
63SA1_27219007_Chip-Seq_Bcells_Human1.31666366
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29596015
65* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.29299122
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29268118
67FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28224513
68RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27667774
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27493673
70ERA_21632823_ChIP-Seq_H3396_Human1.24307841
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22969183
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21512417
73PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20513574
74ATF3_27146783_Chip-Seq_COLON_Human1.18097529
75* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18057856
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18023461
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.17033828
78CTCF_26484167_Chip-Seq_Bcells_Mouse1.15826412
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13145719
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.11910191
81KDM2B_26808549_Chip-Seq_K562_Human1.10486895
82GABP_19822575_ChIP-Seq_HepG2_Human1.10177606
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08790500
84TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08568204
85* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08563726
86* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08073193
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07750789
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07106974
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06400300
90SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06338931
91* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05521710
92P300_27268052_Chip-Seq_Bcells_Human1.04158388
93RUNX1_27514584_Chip-Seq_MCF-7_Human1.00862386
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99691343
95E2F7_22180533_ChIP-Seq_HELA_Human0.99181537
96NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.98314536
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97445310
98OCT4_20526341_ChIP-Seq_ESCs_Human0.96255910
99NCOR1_26117541_ChIP-Seq_K562_Human0.96170888
100OCT4_19829295_ChIP-Seq_ESCs_Human0.95502586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation7.61633496
2MP0001986_abnormal_taste_sensitivity5.29090213
3MP0005423_abnormal_somatic_nervous5.20689655
4MP0005174_abnormal_tail_pigmentation5.08218667
5MP0003136_yellow_coat_color4.03250880
6MP0001661_extended_life_span3.46787799
7MP0000751_myopathy3.29653610
8MP0005083_abnormal_biliary_tract3.27211727
9MP0008875_abnormal_xenobiotic_pharmacok3.23953540
10MP0002638_abnormal_pupillary_reflex2.93388546
11MP0005409_darkened_coat_color2.73305346
12MP0002160_abnormal_reproductive_system2.57689105
13MP0005330_cardiomyopathy2.44732690
14MP0001756_abnormal_urination2.31630680
15MP0001188_hyperpigmentation2.22936826
16MP0003705_abnormal_hypodermis_morpholog2.12671821
17MP0000750_abnormal_muscle_regeneration2.12421313
18MP0003111_abnormal_nucleus_morphology2.10174288
19MP0001502_abnormal_circadian_rhythm1.99572464
20MP0003453_abnormal_keratinocyte_physiol1.98116190
21MP0001968_abnormal_touch/_nociception1.95233049
22MP0000538_abnormal_urinary_bladder1.92886980
23MP0004130_abnormal_muscle_cell1.88359013
24MP0001919_abnormal_reproductive_system1.61477147
25MP0002736_abnormal_nociception_after1.58772680
26MP0005501_abnormal_skin_physiology1.54698320
27MP0003077_abnormal_cell_cycle1.54422650
28MP0005076_abnormal_cell_differentiation1.47449926
29MP0000013_abnormal_adipose_tissue1.46970735
30MP0000747_muscle_weakness1.42209470
31MP0005257_abnormal_intraocular_pressure1.40526372
32MP0000015_abnormal_ear_pigmentation1.39439731
33MP0005410_abnormal_fertilization1.34471762
34MP0001958_emphysema1.31370807
35MP0005332_abnormal_amino_acid1.30760567
36MP0010094_abnormal_chromosome_stability1.29997342
37MP0000470_abnormal_stomach_morphology1.26584361
38MP0002909_abnormal_adrenal_gland1.21144854
39MP0000003_abnormal_adipose_tissue1.20560017
40MP0005551_abnormal_eye_electrophysiolog1.17269440
41MP0002735_abnormal_chemical_nociception1.15058720
42MP0004381_abnormal_hair_follicle1.14069623
43MP0003806_abnormal_nucleotide_metabolis1.13743089
44MP0004185_abnormal_adipocyte_glucose1.13199391
45MP0001664_abnormal_digestion1.04881395
46MP0001348_abnormal_lacrimal_gland1.02599951
47MP0005389_reproductive_system_phenotype1.02413782
48MP0002254_reproductive_system_inflammat1.02021964
49MP0003878_abnormal_ear_physiology1.01919863
50MP0005377_hearing/vestibular/ear_phenot1.01919863
51MP0001346_abnormal_lacrimal_gland1.01638001
52MP0005253_abnormal_eye_physiology0.97471363
53MP0001765_abnormal_ion_homeostasis0.96874641
54MP0005058_abnormal_lysosome_morphology0.93503631
55MP0001324_abnormal_eye_pigmentation0.89914603
56MP0010386_abnormal_urinary_bladder0.88740657
57MP0003448_altered_tumor_morphology0.88010649
58MP0003137_abnormal_impulse_conducting0.81976362
59MP0004957_abnormal_blastocyst_morpholog0.81972340
60MP0000367_abnormal_coat/_hair0.80760999
61MP0004043_abnormal_pH_regulation0.78729458
62MP0004197_abnormal_fetal_growth/weight/0.76083322
63MP0009643_abnormal_urine_homeostasis0.75936907
64MP0002060_abnormal_skin_morphology0.74031475
65MP0005023_abnormal_wound_healing0.73020276
66MP0008770_decreased_survivor_rate0.72942092
67MP0005220_abnormal_exocrine_pancreas0.71203851
68MP0000358_abnormal_cell_content/0.70643012
69MP0005365_abnormal_bile_salt0.70373710
70MP0009931_abnormal_skin_appearance0.70360421
71MP0002751_abnormal_autonomic_nervous0.69697457
72MP0009840_abnormal_foam_cell0.68395077
73MP0003091_abnormal_cell_migration0.67637669
74MP0005584_abnormal_enzyme/coenzyme_acti0.65311498
75MP0010771_integument_phenotype0.62578062
76MP0004087_abnormal_muscle_fiber0.61041171
77MP0002249_abnormal_larynx_morphology0.57928583
78MP0001873_stomach_inflammation0.57385863
79MP0002019_abnormal_tumor_incidence0.55867848
80MP0001191_abnormal_skin_condition0.55237837
81MP0004215_abnormal_myocardial_fiber0.54938683
82MP0001905_abnormal_dopamine_level0.54438171
83MP0004019_abnormal_vitamin_homeostasis0.52825298
84MP0001784_abnormal_fluid_regulation0.52572806
85MP0009278_abnormal_bone_marrow0.52375825
86MP0002210_abnormal_sex_determination0.51519848
87MP0000377_abnormal_hair_follicle0.51111007
88MP0005375_adipose_tissue_phenotype0.51089139
89MP0000759_abnormal_skeletal_muscle0.49245153
90MP0002928_abnormal_bile_duct0.49062646
91MP0003315_abnormal_perineum_morphology0.48563988
92MP0002075_abnormal_coat/hair_pigmentati0.48329220
93MP0009384_cardiac_valve_regurgitation0.47787761
94MP0002136_abnormal_kidney_physiology0.47248461
95MP0003693_abnormal_embryo_hatching0.46828978
96MP0005391_vision/eye_phenotype0.46183741
97MP0010769_abnormal_survival0.45276282
98MP0002080_prenatal_lethality0.44534513
99MP0001270_distended_abdomen0.43306864
100MP0010768_mortality/aging0.43280080

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)7.10576897
2Dyschromatopsia (HP:0007641)6.38751470
3Rib fusion (HP:0000902)6.18761530
4Mesangial abnormality (HP:0001966)6.06234030
5Thin bony cortex (HP:0002753)5.27687678
6Attenuation of retinal blood vessels (HP:0007843)5.21712711
7Poikiloderma (HP:0001029)4.82414925
8Ulnar bowing (HP:0003031)4.80792679
9Prolonged partial thromboplastin time (HP:0003645)4.74386919
10Abnormality of the intrinsic pathway (HP:0010989)4.71245612
11Rectovaginal fistula (HP:0000143)4.68791921
12Rectal fistula (HP:0100590)4.68791921
13Increased hepatocellular lipid droplets (HP:0006565)4.62414263
14Hemorrhage of the eye (HP:0011885)4.59819908
15Annular pancreas (HP:0001734)4.56111504
16Intestinal fistula (HP:0100819)4.53551199
17Joint hemorrhage (HP:0005261)4.51114439
18Popliteal pterygium (HP:0009756)4.42759113
19Lipid accumulation in hepatocytes (HP:0006561)4.38907182
20Facial hemangioma (HP:0000329)4.37798373
21Akinesia (HP:0002304)4.37766475
22Facial diplegia (HP:0001349)4.35201521
23Vaginal fistula (HP:0004320)4.31316405
24Renal Fanconi syndrome (HP:0001994)4.25094280
25Turricephaly (HP:0000262)4.23485441
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.20702875
27Choroideremia (HP:0001139)4.00191380
28Aplasia of the musculature (HP:0100854)3.79423396
29Fetal akinesia sequence (HP:0001989)3.78622458
30Delayed epiphyseal ossification (HP:0002663)3.71284187
31Coronal craniosynostosis (HP:0004440)3.64491748
32Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.55552613
33Decreased electroretinogram (ERG) amplitude (HP:0000654)3.49084138
34Atrioventricular block (HP:0001678)3.46575777
35Myotonia (HP:0002486)3.45186411
36Squamous cell carcinoma (HP:0002860)3.32647129
37Anteriorly placed anus (HP:0001545)3.29112882
38Decreased central vision (HP:0007663)3.29064461
39Patellar aplasia (HP:0006443)3.25932521
40Hypoalbuminemia (HP:0003073)3.25849988
41Abnormal albumin level (HP:0012116)3.25849988
42Bony spicule pigmentary retinopathy (HP:0007737)3.18229942
43Congenital stationary night blindness (HP:0007642)3.12487857
44Increased intramyocellular lipid droplets (HP:0012240)3.08851164
45Amniotic constriction ring (HP:0009775)3.08625282
46Abnormality of placental membranes (HP:0011409)3.08625282
47Aplasia/Hypoplasia of the patella (HP:0006498)3.03731820
48Zonular cataract (HP:0010920)3.02366418
49Neonatal onset (HP:0003623)3.00151955
50Short chin (HP:0000331)2.99519487
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.99014702
52Increased muscle lipid content (HP:0009058)2.95647079
53Exertional dyspnea (HP:0002875)2.93924219
54Abnormality of the costochondral junction (HP:0000919)2.93175189
55Enlarged epiphyses (HP:0010580)2.85617428
56Chorioretinal atrophy (HP:0000533)2.78713188
57Hypophosphatemic rickets (HP:0004912)2.77665007
58Abnormality of the common coagulation pathway (HP:0010990)2.76441577
59Respiratory difficulties (HP:0002880)2.76432482
60Widely patent fontanelles and sutures (HP:0004492)2.63833159
61Capillary hemangiomas (HP:0005306)2.63732869
62Bowed forearm bones (HP:0003956)2.55442483
63Bowing of the arm (HP:0006488)2.55442483
64Abnormal urine phosphate concentration (HP:0012599)2.55179092
65Long clavicles (HP:0000890)2.47261157
66Thin ribs (HP:0000883)2.43951022
67Neonatal respiratory distress (HP:0002643)2.39436340
68Choanal stenosis (HP:0000452)2.37661574
69Abnormal epiphyseal ossification (HP:0010656)2.37318221
70Absent thumb (HP:0009777)2.36257274
71Malignant hyperthermia (HP:0002047)2.33932690
72Flat occiput (HP:0005469)2.32664519
73Abnormality of renal resorption (HP:0011038)2.28068487
74Joint stiffness (HP:0001387)2.27775274
75Aplasia/Hypoplasia involving the musculature (HP:0001460)2.15533691
76Premature graying of hair (HP:0002216)2.14493625
77Narrow nasal bridge (HP:0000446)2.13730288
78Pterygium (HP:0001059)2.08788219
79Myopathic facies (HP:0002058)2.05353831
80Epiphyseal stippling (HP:0010655)2.02325734
81Increased number of teeth (HP:0011069)2.01357692
82Heart block (HP:0012722)2.01266597
83Short humerus (HP:0005792)1.99401042
84Absent radius (HP:0003974)1.94897126
85Cystic hygroma (HP:0000476)1.92444952
86Abnormal atrioventricular conduction (HP:0005150)1.91752807
87Diminished movement (HP:0002374)1.90700616
88Basal cell carcinoma (HP:0002671)1.85204249
89Birth length less than 3rd percentile (HP:0003561)1.84722223
90Renal tubular dysfunction (HP:0000124)1.84333161
91Short thumb (HP:0009778)1.83694339
92Abnormality of the hepatic vasculature (HP:0006707)1.82066074
93Cholelithiasis (HP:0001081)1.81612465
94Aplasia involving forearm bones (HP:0009822)1.81536153
95Absent forearm bone (HP:0003953)1.81536153
96Wide cranial sutures (HP:0010537)1.81284046
97Breast hypoplasia (HP:0003187)1.80270346
98Aplasia/hypoplasia of the humerus (HP:0006507)1.79066078
99Mask-like facies (HP:0000298)1.76683922
100Macular degeneration (HP:0000608)1.71363945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.41601494
2MUSK3.58199588
3TRIB33.11650653
4TLK13.00463325
5BLK2.76833544
6ZAK2.16829518
7TESK22.09646581
8MAPK1511.1081992
9STK161.60708332
10SIK21.54081308
11CCNB11.48022978
12ICK1.42825858
13CDK41.42669218
14IRAK21.42289839
15SIK11.32138926
16WNK11.23567184
17CDK61.22280291
18PDPK11.22195463
19NEK21.20472511
20EEF2K1.18875298
21DYRK1B1.14772569
22ADRBK11.12014370
23MAP2K31.10724129
24BMX1.08928546
25ERN11.06188315
26AURKA1.01724427
27CDK121.00951256
28INSRR1.00123526
29ZAP701.00093395
30PRKD20.99079404
31CDK150.97937061
32MAP3K100.95506270
33CAMK1D0.94837158
34PKN20.93425494
35CHEK20.91048459
36CDK180.89424422
37PIM20.88871931
38CDK11A0.88861639
39ADRBK20.86873655
40PAK10.83635669
41CSK0.78737237
42MTOR0.77312884
43SMG10.75533180
44TBK10.75464448
45ATR0.74874014
46MAPK110.72331670
47RPS6KA60.69978507
48RPS6KC10.68740827
49RPS6KL10.68740827
50RPS6KA20.68693574
51GRK60.68480444
52PRKD10.66691138
53RPS6KA50.64288392
54STK390.63734347
55MAP4K10.63688122
56MAP2K60.63411273
57CDK140.61497768
58STK110.56275813
59EPHB20.55493550
60PDK20.55090142
61MST1R0.53591925
62CAMK1G0.52223964
63CAMKK10.51335821
64MELK0.51113399
65PLK10.51016051
66TTN0.50044234
67PRKAA10.49695847
68PRKD30.48658077
69MAP3K110.47024429
70TRIM280.46463027
71MAPK80.44860039
72PRKCH0.43010246
73ACVR1B0.39348959
74CSNK1D0.37042448
75CDK10.36745161
76PRKCI0.31434320
77MAPK120.31278788
78CDK20.29405866
79AKT20.29258774
80IRAK30.27902848
81MAP2K40.27420430
82ARAF0.26920151
83CDK80.25872349
84MARK20.24672224
85KDR0.23066247
86RIPK10.22544202
87TAOK30.22450514
88TYRO30.21868205
89GSK3B0.21188213
90MAPK140.20607688
91MET0.17851468
92EPHA20.16914562
93AKT10.16311254
94HIPK20.14506054
95PRKCD0.13739045
96PIM10.13489327
97MAPK30.13192568
98RPS6KA10.13104978
99MAP2K20.13039648
100IKBKB0.13033798

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001308.17733001
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006046.29071722
3Sulfur relay system_Homo sapiens_hsa041224.56915811
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.90299027
5Glycosaminoglycan degradation_Homo sapiens_hsa005313.20377294
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.84525230
7Sphingolipid metabolism_Homo sapiens_hsa006002.32720203
8Fructose and mannose metabolism_Homo sapiens_hsa000512.32513002
9Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.11952831
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88142076
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.83654001
12Fanconi anemia pathway_Homo sapiens_hsa034601.63870886
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58023959
14Hedgehog signaling pathway_Homo sapiens_hsa043401.55236243
15Other glycan degradation_Homo sapiens_hsa005111.50573698
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36786993
17mTOR signaling pathway_Homo sapiens_hsa041501.17933560
18Circadian rhythm_Homo sapiens_hsa047101.16178304
19Alcoholism_Homo sapiens_hsa050341.12239856
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10935907
21Lysine degradation_Homo sapiens_hsa003101.09791961
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01801229
23Taste transduction_Homo sapiens_hsa047421.00182066
24Ovarian steroidogenesis_Homo sapiens_hsa049131.00022616
25Systemic lupus erythematosus_Homo sapiens_hsa053220.94807844
26Vitamin digestion and absorption_Homo sapiens_hsa049770.90620756
27Inositol phosphate metabolism_Homo sapiens_hsa005620.90267552
28N-Glycan biosynthesis_Homo sapiens_hsa005100.90091163
29Base excision repair_Homo sapiens_hsa034100.89852421
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81278745
31Phototransduction_Homo sapiens_hsa047440.79252007
32Bladder cancer_Homo sapiens_hsa052190.74422141
33Notch signaling pathway_Homo sapiens_hsa043300.74279149
34Basal cell carcinoma_Homo sapiens_hsa052170.73185795
35Lysosome_Homo sapiens_hsa041420.70195875
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69418496
37Hippo signaling pathway_Homo sapiens_hsa043900.69326468
38Non-homologous end-joining_Homo sapiens_hsa034500.64929676
39Maturity onset diabetes of the young_Homo sapiens_hsa049500.64203716
40Cell cycle_Homo sapiens_hsa041100.62409006
41Nicotine addiction_Homo sapiens_hsa050330.62264311
42Neurotrophin signaling pathway_Homo sapiens_hsa047220.62097634
43Pyruvate metabolism_Homo sapiens_hsa006200.61859332
44Cocaine addiction_Homo sapiens_hsa050300.60779202
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.60621924
46Calcium signaling pathway_Homo sapiens_hsa040200.60263898
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59659457
48VEGF signaling pathway_Homo sapiens_hsa043700.56793926
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56743004
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53706453
51Melanogenesis_Homo sapiens_hsa049160.52578564
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52119483
53RNA polymerase_Homo sapiens_hsa030200.52068227
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52010532
55Glutathione metabolism_Homo sapiens_hsa004800.46157797
56Biosynthesis of amino acids_Homo sapiens_hsa012300.45501934
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44950311
58Pyrimidine metabolism_Homo sapiens_hsa002400.44850642
59Basal transcription factors_Homo sapiens_hsa030220.44003427
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.41216845
61One carbon pool by folate_Homo sapiens_hsa006700.40501257
62Bile secretion_Homo sapiens_hsa049760.38320633
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.38074299
64Endocytosis_Homo sapiens_hsa041440.37820642
65Insulin resistance_Homo sapiens_hsa049310.37211025
66DNA replication_Homo sapiens_hsa030300.34220395
67Chemical carcinogenesis_Homo sapiens_hsa052040.33842344
68Arginine biosynthesis_Homo sapiens_hsa002200.31818642
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31789408
70Homologous recombination_Homo sapiens_hsa034400.31059902
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30728714
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29996275
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28086721
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.28083890
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27671192
76PPAR signaling pathway_Homo sapiens_hsa033200.27494352
77ABC transporters_Homo sapiens_hsa020100.26640129
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26437602
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25186844
80Fatty acid biosynthesis_Homo sapiens_hsa000610.23810747
81Non-small cell lung cancer_Homo sapiens_hsa052230.21713124
82Metabolic pathways_Homo sapiens_hsa011000.21594208
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20778114
84Gap junction_Homo sapiens_hsa045400.20447567
85Cholinergic synapse_Homo sapiens_hsa047250.20144972
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19384991
87Mineral absorption_Homo sapiens_hsa049780.18797983
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15954177
89Viral carcinogenesis_Homo sapiens_hsa052030.11738531
90Chronic myeloid leukemia_Homo sapiens_hsa052200.11735185
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.11577786
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11519223
93Purine metabolism_Homo sapiens_hsa002300.11465449
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.11176902
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09934836
96Apoptosis_Homo sapiens_hsa042100.09872031
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.09801443
98HTLV-I infection_Homo sapiens_hsa051660.06990723
99RNA transport_Homo sapiens_hsa030130.05448299
100Glycerolipid metabolism_Homo sapiens_hsa005610.04675359

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