NTN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endodermal cell differentiation (GO:0035987)4.57613414
2glomerular basement membrane development (GO:0032836)4.24152012
3chondrocyte proliferation (GO:0035988)4.14099128
4skin morphogenesis (GO:0043589)4.11501883
5protein heterotrimerization (GO:0070208)4.00437594
6type B pancreatic cell proliferation (GO:0044342)3.91640330
7sequestering of extracellular ligand from receptor (GO:0035581)3.91411702
8glomerular visceral epithelial cell development (GO:0072015)3.88035046
9cell migration involved in heart development (GO:0060973)3.87825715
10negative regulation of chondrocyte differentiation (GO:0032331)3.83936191
11substrate-dependent cell migration (GO:0006929)3.79655380
12cell-substrate junction assembly (GO:0007044)3.76181478
13actin filament depolymerization (GO:0030042)3.60409413
14regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.58422724
15glomerular epithelial cell development (GO:0072310)3.56856175
16extracellular matrix assembly (GO:0085029)3.49055145
17blood vessel maturation (GO:0001955)3.43742780
18positive regulation of blood vessel endothelial cell migration (GO:0043536)3.36082007
19wound healing, spreading of cells (GO:0044319)3.32807609
20extracellular fibril organization (GO:0043206)3.32801749
21positive regulation of endothelial cell apoptotic process (GO:2000353)3.30903338
22substrate adhesion-dependent cell spreading (GO:0034446)3.28930712
23surfactant homeostasis (GO:0043129)3.28138276
24positive regulation of osteoblast proliferation (GO:0033690)3.27280860
25collagen metabolic process (GO:0032963)3.26611679
26chondrocyte development (GO:0002063)3.23055029
27metanephric tubule development (GO:0072170)3.22584024
28metanephric nephron tubule development (GO:0072234)3.22584024
29retina vasculature morphogenesis in camera-type eye (GO:0061299)3.22051987
30regulation of transforming growth factor beta1 production (GO:0032908)3.20570952
31response to mercury ion (GO:0046689)3.17480266
32extracellular matrix disassembly (GO:0022617)3.17025917
33keratan sulfate catabolic process (GO:0042340)3.16898788
34metanephric nephron epithelium development (GO:0072243)3.12380837
35vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.10466020
36focal adhesion assembly (GO:0048041)3.08554768
37cell-substrate adherens junction assembly (GO:0007045)3.08554768
38negative regulation of fatty acid transport (GO:2000192)3.07662817
39metanephric epithelium development (GO:0072207)3.07502181
40collagen catabolic process (GO:0030574)3.06750447
41multicellular organismal macromolecule metabolic process (GO:0044259)3.05014890
42apoptotic cell clearance (GO:0043277)3.02153126
43adherens junction assembly (GO:0034333)3.01951466
44drug transmembrane transport (GO:0006855)3.00220466
45atrioventricular valve morphogenesis (GO:0003181)2.98564116
46lymph vessel development (GO:0001945)2.96452751
47positive regulation of fibroblast migration (GO:0010763)2.95951158
48Golgi transport vesicle coating (GO:0048200)2.94799989
49COPI coating of Golgi vesicle (GO:0048205)2.94799989
50multicellular organismal metabolic process (GO:0044236)2.92975039
51* extracellular matrix organization (GO:0030198)2.91896402
52* extracellular structure organization (GO:0043062)2.90715428
53smooth muscle tissue development (GO:0048745)2.90228059
54peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.89280037
55regulation of integrin-mediated signaling pathway (GO:2001044)2.88888174
56fibril organization (GO:0097435)2.88858579
57negative regulation of smooth muscle cell migration (GO:0014912)2.87722976
58cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.86007010
59multicellular organismal catabolic process (GO:0044243)2.84024321
60protein retention in ER lumen (GO:0006621)2.83329597
61desmosome organization (GO:0002934)2.83321983
62regulation of transforming growth factor beta2 production (GO:0032909)2.82097268
63lysine catabolic process (GO:0006554)2.81696273
64lysine metabolic process (GO:0006553)2.81696273
65sprouting angiogenesis (GO:0002040)2.81676881
66bone trabecula formation (GO:0060346)2.81571683
67endothelium development (GO:0003158)2.80533967
68negative regulation of cartilage development (GO:0061037)2.79066415
69positive regulation of endothelial cell migration (GO:0010595)2.78879575
70renal filtration (GO:0097205)2.78595097
71glomerulus development (GO:0032835)2.77367567
72maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.76139086
73positive regulation of extracellular matrix organization (GO:1903055)2.74969012
74barbed-end actin filament capping (GO:0051016)2.72695030
75cell adhesion mediated by integrin (GO:0033627)2.68443840
76regulation of chondrocyte differentiation (GO:0032330)2.68270914
77positive regulation of cartilage development (GO:0061036)2.67758894
78mesenchymal-epithelial cell signaling (GO:0060638)2.66398280
79chemical homeostasis within a tissue (GO:0048875)2.65549831
80vascular endothelial growth factor signaling pathway (GO:0038084)2.65397034
81muscle cell migration (GO:0014812)2.64505310
82regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.63616234
83regulation of cartilage development (GO:0061035)2.63383267
84auditory receptor cell stereocilium organization (GO:0060088)2.63209583
85lymphangiogenesis (GO:0001946)2.63132812
86regulation of axon extension involved in axon guidance (GO:0048841)2.62721627
87blood vessel remodeling (GO:0001974)2.61788706
88pericardium development (GO:0060039)2.61377880
89endocardial cushion development (GO:0003197)2.60802463
90hypotonic response (GO:0006971)2.60133957
91cellular response to vitamin (GO:0071295)2.58521603
92nephron tubule development (GO:0072080)2.57544575
93central nervous system myelination (GO:0022010)2.57209858
94axon ensheathment in central nervous system (GO:0032291)2.57209858
95endocrine hormone secretion (GO:0060986)2.56098274
96positive regulation of epithelial cell migration (GO:0010634)2.56009422
97heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.54675548
98cell-substrate adhesion (GO:0031589)2.53319495
99regulation of axon guidance (GO:1902667)2.53004744
100negative regulation of endothelial cell proliferation (GO:0001937)2.51184350
101coronary vasculature morphogenesis (GO:0060977)2.49994266
102negative regulation of cardiac muscle tissue growth (GO:0055022)2.48401179
103negative regulation of heart growth (GO:0061117)2.48401179
104positive regulation of receptor recycling (GO:0001921)2.48232284
105membrane raft organization (GO:0031579)2.47520941
106peptidyl-tyrosine autophosphorylation (GO:0038083)2.46551906
107basement membrane organization (GO:0071711)2.45649233
108cytoskeletal anchoring at plasma membrane (GO:0007016)2.42897886
109urate metabolic process (GO:0046415)2.40639519
110excretion (GO:0007588)2.40486428
111regulation of cardioblast differentiation (GO:0051890)2.40483853
112cell migration involved in sprouting angiogenesis (GO:0002042)2.39665776
113renal absorption (GO:0070293)2.37423656
114nephron epithelium development (GO:0072009)2.37326420
115phosphate ion transport (GO:0006817)2.37314963
116glyoxylate metabolic process (GO:0046487)2.35116658
117negative regulation of axon extension involved in axon guidance (GO:0048843)2.35013431
118aspartate family amino acid catabolic process (GO:0009068)2.34990212
119renal tubule development (GO:0061326)2.33647546
120peripheral nervous system axon ensheathment (GO:0032292)2.32587429
121myelination in peripheral nervous system (GO:0022011)2.32587429
122short-chain fatty acid metabolic process (GO:0046459)2.32279543
123sodium-independent organic anion transport (GO:0043252)2.31507837
124drug catabolic process (GO:0042737)2.31141227
125glomerular filtration (GO:0003094)2.30094493
126myelin maintenance (GO:0043217)2.27217210
127venous blood vessel morphogenesis (GO:0048845)2.25048359
128negative regulation of axon guidance (GO:1902668)2.25034284
129erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.24773847
130L-phenylalanine catabolic process (GO:0006559)2.24773847
131exogenous drug catabolic process (GO:0042738)2.24182900
132negative regulation of Rho protein signal transduction (GO:0035024)2.24011449
133phosphate ion transmembrane transport (GO:0035435)2.23013240
134plasma membrane repair (GO:0001778)2.22491629
135protein localization to endosome (GO:0036010)2.20082433
136creatine metabolic process (GO:0006600)2.19354740
137metanephric mesenchyme development (GO:0072075)2.18280649
138endothelial cell morphogenesis (GO:0001886)2.15988132
139drug transport (GO:0015893)2.15848262
140mesodermal cell differentiation (GO:0048333)2.14688704
141regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.13874821
142neuron projection extension involved in neuron projection guidance (GO:1902284)2.10771911
143axon extension involved in axon guidance (GO:0048846)2.10771911
144adhesion of symbiont to host cell (GO:0044650)2.08565952
145virion attachment to host cell (GO:0019062)2.08565952
146regulation of p38MAPK cascade (GO:1900744)2.08496103
147cysteine metabolic process (GO:0006534)2.07498083
148epithelial cell-cell adhesion (GO:0090136)2.06808934
149positive regulation of p38MAPK cascade (GO:1900745)2.06110432
150kidney mesenchyme development (GO:0072074)2.05799331
151hemidesmosome assembly (GO:0031581)2.04052158
152regulation of glomerular filtration (GO:0003093)2.03846989
153collecting duct development (GO:0072044)2.03573876
154L-phenylalanine metabolic process (GO:0006558)2.03030614
155erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.03030614
156stress fiber assembly (GO:0043149)1.98460151
157wound healing, spreading of epidermal cells (GO:0035313)1.98387944
158regulation of cholesterol homeostasis (GO:2000188)1.97539256
159homocysteine metabolic process (GO:0050667)1.97023959
160regulation of plasminogen activation (GO:0010755)1.96006656
161epithelial cell differentiation involved in kidney development (GO:0035850)1.94844538
162renal tubule morphogenesis (GO:0061333)1.94751926
163negative regulation of protein localization to cell surface (GO:2000009)1.94437532
164renal system process involved in regulation of blood volume (GO:0001977)1.94369273
165cellular response to vascular endothelial growth factor stimulus (GO:0035924)1.93599579
166quaternary ammonium group transport (GO:0015697)1.93569539
167dichotomous subdivision of an epithelial terminal unit (GO:0060600)1.93325345
168semaphorin-plexin signaling pathway (GO:0071526)1.93323664
169camera-type eye morphogenesis (GO:0048593)1.93186027
170negative regulation of fibrinolysis (GO:0051918)1.93149147
171ganglion development (GO:0061548)1.91603045
172heart valve morphogenesis (GO:0003179)1.91437737
173lung vasculature development (GO:0060426)1.89800836
174collagen fibril organization (GO:0030199)1.89356118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.68476121
2* SMAD_19615063_ChIP-ChIP_OVARY_Human3.01308103
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32825860
4RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.32303591
5BRD4_25478319_ChIP-Seq_HGPS_Human2.30961409
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.13623359
7* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12468729
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.02758671
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.02575795
10* EP300_21415370_ChIP-Seq_HL-1_Mouse2.01541508
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00456642
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00456642
13CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.95848703
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94470456
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89077975
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.88937729
17ESR1_21235772_ChIP-Seq_MCF-7_Human1.85707142
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.83804761
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83354039
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.83221233
21* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82806593
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.81080789
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.81080789
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80580710
25EZH2_22144423_ChIP-Seq_EOC_Human1.79576517
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.79079974
27* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77885876
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.75307552
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70017556
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.66360711
31CLOCK_20551151_ChIP-Seq_293T_Human1.65934345
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.65454376
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.64494772
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63262728
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60741059
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60629445
37* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58808497
38GBX2_23144817_ChIP-Seq_PC3_Human1.57315271
39* EZH2_27294783_Chip-Seq_ESCs_Mouse1.53723379
40* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53661490
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52680917
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49476181
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46112972
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.44752824
45* AHR_22903824_ChIP-Seq_MCF-7_Human1.42097157
46* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40021522
47* RNF2_27304074_Chip-Seq_ESCs_Mouse1.39828876
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.39047729
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38775319
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38483997
51AR_21572438_ChIP-Seq_LNCaP_Human1.38259663
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36390316
53* PIAS1_25552417_ChIP-Seq_VCAP_Human1.36144474
54JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34611951
55* ARNT_22903824_ChIP-Seq_MCF-7_Human1.32606825
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.32288159
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.31971196
58DROSHA_22980978_ChIP-Seq_HELA_Human1.31403723
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30833422
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30439354
61* CJUN_26792858_Chip-Seq_BT549_Human1.28941138
62SMC1_22415368_ChIP-Seq_MEFs_Mouse1.27267758
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26880837
64* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26027519
65* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.25771216
66JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25751058
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24516784
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24213747
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24213747
70TP53_18474530_ChIP-ChIP_U2OS_Human1.23908590
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23699943
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.23071157
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.21463312
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20921247
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20711055
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19374883
77* UBF1/2_26484160_Chip-Seq_HMECs_Human1.18864285
78TP53_16413492_ChIP-PET_HCT116_Human1.18564933
79TP53_22127205_ChIP-Seq_IMR90_Human1.16372422
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14986422
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.14737564
82TBX20_22328084_ChIP-Seq_HEART_Mouse1.14314990
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.14314990
84TP53_23651856_ChIP-Seq_MEFs_Mouse1.14286293
85ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13000834
86CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12423918
87* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11813512
88PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10443938
89ZNF263_19887448_ChIP-Seq_K562_Human1.09654138
90PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09436057
91PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07383246
92SA1_22415368_ChIP-Seq_MEFs_Mouse1.07314669
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06140482
94* FOXA2_19822575_ChIP-Seq_HepG2_Human1.05704324
95* RING1B_27294783_Chip-Seq_ESCs_Mouse1.05075329
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04562089
97SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04220146
98BCAT_22108803_ChIP-Seq_LS180_Human1.03849452
99SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03660225
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03282548
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03063040
102SMAD3_21741376_ChIP-Seq_HESCs_Human1.02338685
103RACK7_27058665_Chip-Seq_MCF-7_Human1.02158333
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02056476
105CDX2_20551321_ChIP-Seq_CACO-2_Human1.01319413
106* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01181666
107CBX2_27304074_Chip-Seq_ESCs_Mouse0.99901044
108* TP53_20018659_ChIP-ChIP_R1E_Mouse0.99041261
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98837683
110* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98484936
111* SOX2_20726797_ChIP-Seq_SW620_Human0.98067206
112TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97217285
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96915896
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96565700
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96448796
116NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96393727
117SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96340231
118ISL1_27105846_Chip-Seq_CPCs_Mouse0.95647218
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94174255
120FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92434964
121TCF4_18268006_ChIP-ChIP_LS174T_Human0.91359958
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91091748
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89411267
124SOX2_21211035_ChIP-Seq_LN229_Gbm0.88613736
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88531082
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88404563
127* RING1B_27294783_Chip-Seq_NPCs_Mouse0.87604166
128SMAD4_21799915_ChIP-Seq_A2780_Human0.87380430
129* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86715095
130ATF3_27146783_Chip-Seq_COLON_Human0.86546577
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85901964
132CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85835023
133TET1_21490601_ChIP-Seq_MESCs_Mouse0.85684658
134NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85548849
135TP63_23658742_ChIP-Seq_EP156T_Human0.85002134
136ZNF274_21170338_ChIP-Seq_K562_Hela0.84952277
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84198620
138TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82958361
139KDM2B_26808549_Chip-Seq_K562_Human0.82669800
140PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81842127
141SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81725937
142SMAD3_21741376_ChIP-Seq_EPCs_Human0.81333471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane3.28242228
2MP0001958_emphysema2.96872841
3MP0005623_abnormal_meninges_morphology2.91164362
4MP0005257_abnormal_intraocular_pressure2.80143294
5MP0008438_abnormal_cutaneous_collagen2.71704974
6MP0009384_cardiac_valve_regurgitation2.65324052
7MP0010368_abnormal_lymphatic_system2.57107792
8MP0005360_urolithiasis2.55282120
9MP0002139_abnormal_hepatobiliary_system2.49564217
10MP0006054_spinal_hemorrhage2.33696827
11MP0004043_abnormal_pH_regulation2.31302276
12MP0005503_abnormal_tendon_morphology2.28758788
13MP0003195_calcinosis2.22178228
14MP0005275_abnormal_skin_tensile2.14443619
15MP0010030_abnormal_orbit_morphology2.00472296
16MP0000751_myopathy1.99377130
17MP0001542_abnormal_bone_strength1.98919391
18MP0005023_abnormal_wound_healing1.96328264
19MP0004885_abnormal_endolymph1.92036801
20MP0001879_abnormal_lymphatic_vessel1.91516042
21MP0002138_abnormal_hepatobiliary_system1.82628481
22MP0005332_abnormal_amino_acid1.81677654
23MP0004084_abnormal_cardiac_muscle1.80987005
24MP0003252_abnormal_bile_duct1.70773640
25MP0002060_abnormal_skin_morphology1.65242408
26MP0008875_abnormal_xenobiotic_pharmacok1.62978155
27MP0003705_abnormal_hypodermis_morpholog1.60377652
28MP0010352_gastrointestinal_tract_polyps1.56579590
29MP0005167_abnormal_blood-brain_barrier1.55507752
30MP0003279_aneurysm1.53742516
31MP0002837_dystrophic_cardiac_calcinosis1.51810492
32MP0001756_abnormal_urination1.49530518
33MP0009643_abnormal_urine_homeostasis1.49233373
34MP0002295_abnormal_pulmonary_circulatio1.48991188
35MP0000537_abnormal_urethra_morphology1.43641454
36MP0002108_abnormal_muscle_morphology1.41218454
37MP0001765_abnormal_ion_homeostasis1.39353233
38MP0004036_abnormal_muscle_relaxation1.39343779
39MP0009780_abnormal_chondrocyte_physiolo1.38218758
40MP0002877_abnormal_melanocyte_morpholog1.36363175
41MP0000534_abnormal_ureter_morphology1.31069287
42MP0006138_congestive_heart_failure1.30581261
43MP0005085_abnormal_gallbladder_physiolo1.28543924
44MP0002896_abnormal_bone_mineralization1.27622882
45MP0001348_abnormal_lacrimal_gland1.25510603
46MP0003950_abnormal_plasma_membrane1.25262417
47MP0004019_abnormal_vitamin_homeostasis1.24888159
48MP0000747_muscle_weakness1.24643972
49MP0003566_abnormal_cell_adhesion1.24570670
50MP0003045_fibrosis1.23072165
51MP0005365_abnormal_bile_salt1.22573107
52MP0000749_muscle_degeneration1.20448360
53MP0000920_abnormal_myelination1.20416379
54MP0002168_other_aberrant_phenotype1.19440431
55MP0004742_abnormal_vestibular_system1.19101914
56MP0000230_abnormal_systemic_arterial1.17046687
57MP0002136_abnormal_kidney_physiology1.15722640
58MP0005330_cardiomyopathy1.15471099
59MP0002972_abnormal_cardiac_muscle1.12434387
60MP0004484_altered_response_of1.11797002
61MP0000013_abnormal_adipose_tissue1.11031854
62MP0005620_abnormal_muscle_contractility1.10922280
63MP0003828_pulmonary_edema1.10285091
64MP0001243_abnormal_dermal_layer1.07068565
65MP0001299_abnormal_eye_distance/1.06573934
66MP0005084_abnormal_gallbladder_morpholo1.05699299
67MP0003941_abnormal_skin_development1.03361853
68MP0003329_amyloid_beta_deposits1.03190433
69MP0004215_abnormal_myocardial_fiber1.01268256
70MP0005377_hearing/vestibular/ear_phenot1.00910236
71MP0003878_abnormal_ear_physiology1.00910236
72MP0000733_abnormal_muscle_development0.99917063
73MP0004233_abnormal_muscle_weight0.99530661
74MP0005595_abnormal_vascular_smooth0.99353489
75MP0005197_abnormal_uvea_morphology0.97101327
76MP0004858_abnormal_nervous_system0.96805207
77MP0005165_increased_susceptibility_to0.96569852
78MP0000767_abnormal_smooth_muscle0.96255958
79MP0003091_abnormal_cell_migration0.96148895
80MP0008775_abnormal_heart_ventricle0.96003398
81MP0002282_abnormal_trachea_morphology0.95851030
82MP0005164_abnormal_response_to0.95358518
83MP0000003_abnormal_adipose_tissue0.95291867
84MP0001915_intracranial_hemorrhage0.95179937
85MP0010386_abnormal_urinary_bladder0.95122648
86MP0003942_abnormal_urinary_system0.94577000
87MP0004087_abnormal_muscle_fiber0.94527933
88MP0004085_abnormal_heartbeat0.94208072
89MP0003283_abnormal_digestive_organ0.93105765
90MP0001661_extended_life_span0.93040526
91MP0001614_abnormal_blood_vessel0.92530023
92MP0000762_abnormal_tongue_morphology0.90531201
93MP0004145_abnormal_muscle_electrophysio0.89112137
94MP0003690_abnormal_glial_cell0.88607420
95MP0005390_skeleton_phenotype0.87290251
96MP0000759_abnormal_skeletal_muscle0.87088555
97MP0003191_abnormal_cellular_cholesterol0.86924851
98MP0004134_abnormal_chest_morphology0.85345822
99MP0009250_abnormal_appendicular_skeleto0.85260418
100MP0001849_ear_inflammation0.84961548
101MP0005409_darkened_coat_color0.83834938
102MP0003137_abnormal_impulse_conducting0.83525496
103MP0002796_impaired_skin_barrier0.83335302
104MP0005385_cardiovascular_system_phenoty0.83214187
105MP0001544_abnormal_cardiovascular_syste0.83214187
106MP0003300_gastrointestinal_ulcer0.83151099
107MP0000750_abnormal_muscle_regeneration0.82988246
108MP0000467_abnormal_esophagus_morphology0.81544472
109MP0002133_abnormal_respiratory_system0.80310038
110MP0005388_respiratory_system_phenotype0.80310038
111MP0005083_abnormal_biliary_tract0.80270241
112MP0005508_abnormal_skeleton_morphology0.78711067
113MP0002925_abnormal_cardiovascular_devel0.76581285
114MP0001177_atelectasis0.76090701
115MP0003385_abnormal_body_wall0.74998622
116MP0002128_abnormal_blood_circulation0.74579609
117MP0003634_abnormal_glial_cell0.74552064
118MP0000163_abnormal_cartilage_morphology0.73842281
119MP0005193_abnormal_anterior_eye0.73735671
120MP0003868_abnormal_feces_composition0.73363695
121MP0000462_abnormal_digestive_system0.73226354
122MP0002933_joint_inflammation0.72979098
123MP0003755_abnormal_palate_morphology0.72845407
124MP0002234_abnormal_pharynx_morphology0.71950554
125MP0002932_abnormal_joint_morphology0.71776403
126MP0005369_muscle_phenotype0.71732598
127MP0002115_abnormal_skeleton_extremities0.71247638
128MP0000579_abnormal_nail_morphology0.70981448
129MP0005666_abnormal_adipose_tissue0.70583277
130MP0000049_abnormal_middle_ear0.70271579
131MP0005670_abnormal_white_adipose0.69094392
132MP0005171_absent_coat_pigmentation0.68534414
133MP0003115_abnormal_respiratory_system0.68046434
134MP0000538_abnormal_urinary_bladder0.67791120
135MP0003448_altered_tumor_morphology0.67542287
136MP0009053_abnormal_anal_canal0.67485084
137MP0000428_abnormal_craniofacial_morphol0.66009422
138MP0002113_abnormal_skeleton_development0.65544552
139MP0000432_abnormal_head_morphology0.63590244
140MP0003935_abnormal_craniofacial_develop0.63311183
141MP0000249_abnormal_blood_vessel0.61389789
142MP0004782_abnormal_surfactant_physiolog0.60023029
143MP0001270_distended_abdomen0.59606666
144MP0001175_abnormal_lung_morphology0.57729845
145MP0004883_abnormal_blood_vessel0.55980765

Predicted human phenotypes

RankGene SetZ-score
1Hypokalemic alkalosis (HP:0001949)4.88910398
2Arterial tortuosity (HP:0005116)4.75745648
3Increased circulating renin level (HP:0000848)4.68278775
4Hyperactive renin-angiotensin system (HP:0000841)4.29802575
5Metabolic alkalosis (HP:0200114)4.24848461
6Soft skin (HP:0000977)4.22079565
7Abnormality of chloride homeostasis (HP:0011422)3.89363801
8Hypomagnesemia (HP:0002917)3.84437625
9Muscle fiber splitting (HP:0003555)3.77575043
10Fragile skin (HP:0001030)3.70366786
11Bladder diverticulum (HP:0000015)3.70050109
12Focal segmental glomerulosclerosis (HP:0000097)3.60075739
13Abnormality of dentin (HP:0010299)3.59607027
14Spondylolisthesis (HP:0003302)3.51770217
15Facial shape deformation (HP:0011334)3.45055947
16Potter facies (HP:0002009)3.45055947
17Gout (HP:0001997)3.41862336
18Mitral valve prolapse (HP:0001634)3.38165764
19Wormian bones (HP:0002645)3.37065947
20Ankle contracture (HP:0006466)3.34290461
21Abnormal urine output (HP:0012590)3.22171231
22Follicular hyperkeratosis (HP:0007502)3.20095170
23Polyuria (HP:0000103)3.17799756
24Hyperaldosteronism (HP:0000859)3.17269945
25Cervical subluxation (HP:0003308)3.16261408
26Dilatation of the ascending aorta (HP:0005111)3.16182801
27Glomerulosclerosis (HP:0000096)3.15104959
28Premature rupture of membranes (HP:0001788)3.13996189
29Blue sclerae (HP:0000592)3.12431590
30Renal salt wasting (HP:0000127)3.11318048
31Abnormality of renal excretion (HP:0011036)3.09216431
32Abnormality of magnesium homeostasis (HP:0004921)3.08280341
33Abnormality of renin-angiotensin system (HP:0000847)3.07462186
34Peritonitis (HP:0002586)3.05825483
35Aortic regurgitation (HP:0001659)3.03074099
36Tetany (HP:0001281)3.00206464
37Neonatal short-limb short stature (HP:0008921)3.00174258
38Genu recurvatum (HP:0002816)2.97718090
39Overgrowth (HP:0001548)2.86814334
40Cardiovascular calcification (HP:0011915)2.84425053
41Hypoplasia of the iris (HP:0007676)2.81930911
42Right ventricular cardiomyopathy (HP:0011663)2.79720137
43Abnormal drinking behavior (HP:0030082)2.77043610
44Polydipsia (HP:0001959)2.77043610
45Broad metatarsal (HP:0001783)2.74699100
46Joint laxity (HP:0001388)2.69360817
47Alkalosis (HP:0001948)2.68710049
48Hyporeflexia of lower limbs (HP:0002600)2.68575147
49Vascular calcification (HP:0004934)2.66605949
50Aneurysm (HP:0002617)2.59496673
51Hyperextensible skin (HP:0000974)2.58378832
52Mitral regurgitation (HP:0001653)2.54877521
53Aortic valve stenosis (HP:0001650)2.53134572
54Bowel diverticulosis (HP:0005222)2.47929325
55Hypokalemia (HP:0002900)2.47897579
56Abnormal delivery (HP:0001787)2.47881236
57Protrusio acetabuli (HP:0003179)2.43834428
58Deep venous thrombosis (HP:0002625)2.43438831
59Abnormality of the acetabulum (HP:0003170)2.43371389
60Mildly elevated creatine phosphokinase (HP:0008180)2.42769372
61Mitral stenosis (HP:0001718)2.42360728
62Abnormality of glutamine family amino acid metabolism (HP:0010902)2.41615508
63Ectopia lentis (HP:0001083)2.38825519
64Vertebral compression fractures (HP:0002953)2.37697932
65Mesomelia (HP:0003027)2.36975657
66Osteolytic defects of the hand bones (HP:0009699)2.36740888
67Osteolytic defects of the phalanges of the hand (HP:0009771)2.36740888
68Biconcave vertebral bodies (HP:0004586)2.35428500
69Wrist flexion contracture (HP:0001239)2.34657628
70Abnormality of potassium homeostasis (HP:0011042)2.33822810
71Neurofibrillary tangles (HP:0002185)2.33758635
72Shallow orbits (HP:0000586)2.32825451
73Wide anterior fontanel (HP:0000260)2.27982937
74Increased connective tissue (HP:0009025)2.26819401
75Short nail (HP:0001799)2.20669591
76Aplasia of the musculature (HP:0100854)2.19581744
77Tubulointerstitial fibrosis (HP:0005576)2.19179648
78Cerebral hemorrhage (HP:0001342)2.19113514
79Hydroxyprolinuria (HP:0003080)2.18680609
80Abnormality of proline metabolism (HP:0010907)2.18680609
81Aortic dissection (HP:0002647)2.18599919
82Hyperuricemia (HP:0002149)2.17071185
83Increased purine levels (HP:0004368)2.17071185
84Joint stiffness (HP:0001387)2.16370926
85Lymphangioma (HP:0100764)2.13829522
86Aortic aneurysm (HP:0004942)2.13093865
87Disproportionate tall stature (HP:0001519)2.11582810
88Ketoacidosis (HP:0001993)2.09094284
89Mesangial abnormality (HP:0001966)2.08821275
90Polycythemia (HP:0001901)2.08050209
91Slender build (HP:0001533)2.07712715
92Atrophic scars (HP:0001075)2.06855422
93Abnormality of skeletal muscle fiber size (HP:0012084)2.06323535
94Abnormality of the calf musculature (HP:0001430)2.03856342
95Elbow flexion contracture (HP:0002987)2.03314166
96Sudden death (HP:0001699)2.01598904
97Round ear (HP:0100830)2.01499585
98Difficulty running (HP:0009046)2.00229792
99Osteoarthritis (HP:0002758)1.99074493
100Ulnar bowing (HP:0003031)1.98754117
101Pulmonary artery stenosis (HP:0004415)1.98351812
102Chondrocalcinosis (HP:0000934)1.96931515
103Abnormality of the middle phalanges of the toes (HP:0010183)1.96063492
104Camptodactyly of toe (HP:0001836)1.95904407
105Distal lower limb muscle weakness (HP:0009053)1.94523980
106Stage 5 chronic kidney disease (HP:0003774)1.93980804
107Cerebral inclusion bodies (HP:0100314)1.93079097
108Hyperkalemia (HP:0002153)1.91557111
109Type 1 muscle fiber predominance (HP:0003803)1.91114608
110Gowers sign (HP:0003391)1.90721109
111Increased variability in muscle fiber diameter (HP:0003557)1.90135807
112Cerebral aneurysm (HP:0004944)1.89169668
113Striae distensae (HP:0001065)1.89078953
114Nonimmune hydrops fetalis (HP:0001790)1.87855607
115Broad ribs (HP:0000885)1.87719256
116Renal duplication (HP:0000075)1.87672066
117Vascular tortuosity (HP:0004948)1.87301995
118Visceral angiomatosis (HP:0100761)1.85958609
119Abnormality of Sharpey fibers (HP:0100685)1.85919449
120Aplasia involving bones of the extremities (HP:0009825)1.85629225
121Aplasia involving bones of the upper limbs (HP:0009823)1.85629225
122Aplasia of the phalanges of the hand (HP:0009802)1.85629225
123Adrenal overactivity (HP:0002717)1.85549731
124Hypoplastic left heart (HP:0004383)1.83935209
125Spinal rigidity (HP:0003306)1.82708055
126Upper limb amyotrophy (HP:0009129)1.81958214
127Distal upper limb amyotrophy (HP:0007149)1.81958214
128Hypercalciuria (HP:0002150)1.80904055
129Xanthomatosis (HP:0000991)1.80679504
130Abnormality of purine metabolism (HP:0004352)1.80678606
131Inguinal hernia (HP:0000023)1.80596972
132Coxa vara (HP:0002812)1.80530467
133Abnormality of the anterior chamber (HP:0000593)1.79627365
134Nephritis (HP:0000123)1.79139892
135Coronal craniosynostosis (HP:0004440)1.78652395
136Broad face (HP:0000283)1.77984919
137Venous insufficiency (HP:0005293)1.76811615
138Generalized muscle weakness (HP:0003324)1.74794763
139Hip contracture (HP:0003273)1.74307177
140Reduced subcutaneous adipose tissue (HP:0003758)1.74155616
141Short hallux (HP:0010109)1.74154588
142Thin bony cortex (HP:0002753)1.73691389
143Humeroradial synostosis (HP:0003041)1.71940922
144Synostosis involving the elbow (HP:0003938)1.71940922
145Knee flexion contracture (HP:0006380)1.71667839
146Ketosis (HP:0001946)1.71359593
147Natal tooth (HP:0000695)1.71336306
148Exercise-induced myalgia (HP:0003738)1.71111942
149Absent frontal sinuses (HP:0002688)1.70972653
150EMG: myopathic abnormalities (HP:0003458)1.70749636
151Abnormality of carpal bone ossification (HP:0006257)1.70252049
152Hypoplastic heart (HP:0001961)1.69581769
153Ovoid vertebral bodies (HP:0003300)1.69269492
154Scapular winging (HP:0003691)1.68456399
155Pulmonic stenosis (HP:0001642)1.68332220
156Infantile muscular hypotonia (HP:0008947)1.67865644
157Hypoventilation (HP:0002791)1.67520569
158Joint contractures involving the joints of the feet (HP:0100492)1.66678725
159Flexion contracture of toe (HP:0005830)1.66678725
160Flared iliac wings (HP:0002869)1.65984474
161Venous abnormality (HP:0002624)1.65716142
162Proximal tubulopathy (HP:0000114)1.65544040
163Flat cornea (HP:0007720)1.65465466
164Pterygium (HP:0001059)1.64891667
165Congenital glaucoma (HP:0001087)1.64638797
166Intrahepatic cholestasis (HP:0001406)1.64344241
167Redundant skin (HP:0001582)1.63640115
168Esophageal varix (HP:0002040)1.63163697
169Calf muscle hypertrophy (HP:0008981)1.63030032
170Limited hip movement (HP:0008800)1.62850051
171Thin skin (HP:0000963)1.62388482
172Abnormal ossification of hand bones (HP:0005921)1.62242514
173Distal lower limb amyotrophy (HP:0008944)1.61611814
174Hyperglycinuria (HP:0003108)1.60819167
175Premature skin wrinkling (HP:0100678)1.60584267
176Hemangiomatosis (HP:0007461)1.60408840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.59198143
2OXSR13.92725611
3STK393.32036293
4WNK33.24165767
5TIE13.09115676
6TESK12.65107803
7EPHA22.48261868
8NEK92.47430058
9EPHB22.28161866
10TGFBR22.05658997
11LATS22.00439630
12MYLK1.94590121
13TTN1.85160220
14LATS11.81883530
15EPHB11.78800352
16DDR21.74007771
17RIPK11.72988076
18TRIB31.67683499
19FER1.51727336
20PKN11.50415835
21PDGFRA1.43872880
22ERN11.43385241
23MST41.36671456
24PAK31.33044744
25SGK2231.32900046
26SGK4941.32900046
27MUSK1.32486926
28PTK61.31018809
29WNK11.30739095
30INSRR1.28752327
31MAP3K31.27902773
32PTK21.27121410
33NTRK11.21452017
34PIK3CA1.20140042
35MAP3K61.19352292
36CDC42BPA1.17672355
37FGFR41.16759900
38PRKG21.14824058
39PHKG11.13904525
40PHKG21.13904525
41PAK21.11440735
42MET1.11117743
43CAMK1G1.07937768
44SIK11.07007166
45PIK3CG1.04350044
46OBSCN1.03723028
47ROCK21.01021092
48DMPK0.97445728
49MST1R0.96062370
50GSK3A0.95430989
51PRKD10.94995703
52MAPK150.94647807
53DYRK1B0.94448410
54MAP3K120.94377790
55ROCK10.92576482
56AKT30.91441563
57RPS6KA20.90958556
58PTK2B0.90797770
59STK38L0.89402565
60MAPK70.86660342
61CSNK1A1L0.86395429
62ERBB40.85662461
63ICK0.85245319
64PDK20.84437558
65FLT30.83861767
66MTOR0.80688829
67PRKD30.80632618
68LRRK20.80002775
69FGFR20.79855591
70TRPM70.78499892
71MAP3K70.75375201
72STK240.74138071
73PAK40.73504714
74PDGFRB0.73303985
75PRKCH0.73037893
76PRKCE0.72869592
77CAMK2B0.72755516
78CAMK1D0.71892620
79SGK30.70966337
80ABL20.70573002
81KDR0.70303855
82LIMK10.69595582
83DAPK30.69486806
84LMTK20.68107159
85MAPKAPK30.66547985
86PAK60.66436764
87BCR0.65122063
88BCKDK0.64269478
89MAPK120.64203028
90STK30.63382096
91CSNK1G10.62723769
92PDK40.61502322
93PDK30.61502322
94PKN20.60951537
95CAMK2D0.60784742
96MARK10.60608125
97MAP2K10.60514606
98ILK0.59703347
99CAMK2G0.59350618
100CSNK1G30.59087962
101EPHA30.59012464
102CSNK1G20.58965179
103DAPK20.58772036
104MAP3K20.57770275
105MARK20.57123286
106PDPK10.55823302
107BMX0.55320783
108CAMK2A0.54932253
109SGK20.54917462
110MOS0.51656009
111RET0.51327662
112PRKD20.50864561
113TYRO30.50317026
114CDK80.50302372
115PRKAA20.49073248
116NTRK20.48826371
117GRK10.47062279
118SRC0.46756455
119MELK0.46726453
120TGFBR10.44563439
121STK380.43436413
122SCYL20.42634390
123CASK0.42319563
124ADRBK10.42261442
125INSR0.40246496
126MAP2K20.40146277
127JAK10.37565708
128KIT0.37358485
129GRK50.36910414
130CDK90.36234849
131ARAF0.35786092
132MAP2K30.35097774
133KSR20.33110645
134ZAP700.32494613
135IRAK30.31018632
136EEF2K0.31004600
137PIM20.28510005
138RPS6KC10.26721358
139RPS6KL10.26721358
140PAK10.25396220

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.82260612
2Nitrogen metabolism_Homo sapiens_hsa009102.33014561
3ECM-receptor interaction_Homo sapiens_hsa045122.24280439
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.96757967
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.95846359
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93191242
7Glycosaminoglycan degradation_Homo sapiens_hsa005311.91247264
8Butanoate metabolism_Homo sapiens_hsa006501.87595555
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.86253818
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76575841
11Propanoate metabolism_Homo sapiens_hsa006401.75489388
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.62095906
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61866765
14Fatty acid degradation_Homo sapiens_hsa000711.60564218
15Protein digestion and absorption_Homo sapiens_hsa049741.56974884
16Bile secretion_Homo sapiens_hsa049761.52533406
17Dilated cardiomyopathy_Homo sapiens_hsa054141.51799556
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44525159
19Focal adhesion_Homo sapiens_hsa045101.42191614
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41694308
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41557160
22Fatty acid metabolism_Homo sapiens_hsa012121.40331948
23beta-Alanine metabolism_Homo sapiens_hsa004101.39544959
24Tryptophan metabolism_Homo sapiens_hsa003801.38920517
25Arginine biosynthesis_Homo sapiens_hsa002201.22543112
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20347174
27PPAR signaling pathway_Homo sapiens_hsa033201.19206095
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17402518
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13024383
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.12723820
31* Axon guidance_Homo sapiens_hsa043601.10285541
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09359444
33Fatty acid elongation_Homo sapiens_hsa000621.07978488
34Amoebiasis_Homo sapiens_hsa051461.07757323
35Histidine metabolism_Homo sapiens_hsa003401.06595676
36Sulfur metabolism_Homo sapiens_hsa009201.06575618
37Peroxisome_Homo sapiens_hsa041461.06477915
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06226891
39Melanoma_Homo sapiens_hsa052181.05542323
40Pathways in cancer_Homo sapiens_hsa052001.04456513
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04413043
42Pyruvate metabolism_Homo sapiens_hsa006201.04023059
43Vitamin digestion and absorption_Homo sapiens_hsa049771.02938203
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02006419
45MicroRNAs in cancer_Homo sapiens_hsa052061.01432244
46Prion diseases_Homo sapiens_hsa050201.01376263
47Complement and coagulation cascades_Homo sapiens_hsa046101.01229462
48Chronic myeloid leukemia_Homo sapiens_hsa052200.99257052
49Basal cell carcinoma_Homo sapiens_hsa052170.98768023
50Gastric acid secretion_Homo sapiens_hsa049710.97626371
51Melanogenesis_Homo sapiens_hsa049160.94087661
52Tight junction_Homo sapiens_hsa045300.93434071
53Mineral absorption_Homo sapiens_hsa049780.92655551
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90715231
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.89972320
56Malaria_Homo sapiens_hsa051440.88906634
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87105953
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84022645
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83768825
60Arginine and proline metabolism_Homo sapiens_hsa003300.83171942
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.82584032
62Chemical carcinogenesis_Homo sapiens_hsa052040.82502824
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.81150904
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80405459
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79722663
66Vibrio cholerae infection_Homo sapiens_hsa051100.79492244
67Renin secretion_Homo sapiens_hsa049240.79332050
68Glioma_Homo sapiens_hsa052140.79230807
69Pancreatic cancer_Homo sapiens_hsa052120.79149384
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.78422153
71Retinol metabolism_Homo sapiens_hsa008300.77869302
72Phenylalanine metabolism_Homo sapiens_hsa003600.76711702
73Endocytosis_Homo sapiens_hsa041440.76570974
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75509920
75Lysine degradation_Homo sapiens_hsa003100.73986786
76Dorso-ventral axis formation_Homo sapiens_hsa043200.73063803
77Cardiac muscle contraction_Homo sapiens_hsa042600.71936335
78Proteoglycans in cancer_Homo sapiens_hsa052050.69608502
79Ovarian steroidogenesis_Homo sapiens_hsa049130.69349998
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69187390
81Adherens junction_Homo sapiens_hsa045200.68753000
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67971132
83Notch signaling pathway_Homo sapiens_hsa043300.67083915
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66350798
85Starch and sucrose metabolism_Homo sapiens_hsa005000.65581015
86Platelet activation_Homo sapiens_hsa046110.64710363
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63078702
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.62908968
89Salivary secretion_Homo sapiens_hsa049700.62040851
90Thyroid hormone synthesis_Homo sapiens_hsa049180.61266183
91Wnt signaling pathway_Homo sapiens_hsa043100.60923757
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60757012
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59854792
94Shigellosis_Homo sapiens_hsa051310.59549286
95GnRH signaling pathway_Homo sapiens_hsa049120.59477650
96Renin-angiotensin system_Homo sapiens_hsa046140.59171062
97Collecting duct acid secretion_Homo sapiens_hsa049660.58841083
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.58774103
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58137251
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57853370
101Prostate cancer_Homo sapiens_hsa052150.57712824
102Galactose metabolism_Homo sapiens_hsa000520.57597620
103Ras signaling pathway_Homo sapiens_hsa040140.56676904
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.54901901
105Rap1 signaling pathway_Homo sapiens_hsa040150.54852293
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54804390
107Pancreatic secretion_Homo sapiens_hsa049720.54407958
108Tyrosine metabolism_Homo sapiens_hsa003500.54176443
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53830512
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53670697
111Thyroid cancer_Homo sapiens_hsa052160.53634835
112Small cell lung cancer_Homo sapiens_hsa052220.53595993
113Bladder cancer_Homo sapiens_hsa052190.53517495
114Hippo signaling pathway_Homo sapiens_hsa043900.52888493
115Estrogen signaling pathway_Homo sapiens_hsa049150.52233980
116Circadian rhythm_Homo sapiens_hsa047100.52201620
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51903628
118ABC transporters_Homo sapiens_hsa020100.51029426
119Other glycan degradation_Homo sapiens_hsa005110.50849713
120Pertussis_Homo sapiens_hsa051330.49873262
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49845736
122Gap junction_Homo sapiens_hsa045400.49424032
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49197897
124Insulin secretion_Homo sapiens_hsa049110.49088748
125cAMP signaling pathway_Homo sapiens_hsa040240.48147932
126N-Glycan biosynthesis_Homo sapiens_hsa005100.48097259
127Endometrial cancer_Homo sapiens_hsa052130.47987683
128Hedgehog signaling pathway_Homo sapiens_hsa043400.47750898
129TGF-beta signaling pathway_Homo sapiens_hsa043500.47558846
130Glutathione metabolism_Homo sapiens_hsa004800.47167018
131MAPK signaling pathway_Homo sapiens_hsa040100.46680947
132GABAergic synapse_Homo sapiens_hsa047270.45784525
133AMPK signaling pathway_Homo sapiens_hsa041520.44953800
134Fatty acid biosynthesis_Homo sapiens_hsa000610.44667093
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44405784
136ErbB signaling pathway_Homo sapiens_hsa040120.43032954
137Renal cell carcinoma_Homo sapiens_hsa052110.43000977
138Choline metabolism in cancer_Homo sapiens_hsa052310.42143284
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41269512
140Taste transduction_Homo sapiens_hsa047420.41259105
141Cocaine addiction_Homo sapiens_hsa050300.41235259
142Insulin resistance_Homo sapiens_hsa049310.41223935
143Carbon metabolism_Homo sapiens_hsa012000.41091819
144Salmonella infection_Homo sapiens_hsa051320.40544606
145Caffeine metabolism_Homo sapiens_hsa002320.40370268
146Fat digestion and absorption_Homo sapiens_hsa049750.40262466
147Oxytocin signaling pathway_Homo sapiens_hsa049210.40196877
148Sphingolipid metabolism_Homo sapiens_hsa006000.39266307
149TNF signaling pathway_Homo sapiens_hsa046680.38708918
150Lysosome_Homo sapiens_hsa041420.38353387
151Insulin signaling pathway_Homo sapiens_hsa049100.35956976
152Inositol phosphate metabolism_Homo sapiens_hsa005620.35748452
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35553368
154Glucagon signaling pathway_Homo sapiens_hsa049220.34234818
155mTOR signaling pathway_Homo sapiens_hsa041500.32606429

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