NTN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.05308827
2ionotropic glutamate receptor signaling pathway (GO:0035235)5.95925793
3indole-containing compound catabolic process (GO:0042436)5.60884829
4indolalkylamine catabolic process (GO:0046218)5.60884829
5tryptophan catabolic process (GO:0006569)5.60884829
6kynurenine metabolic process (GO:0070189)5.56694866
7behavioral response to nicotine (GO:0035095)5.47097936
8synaptic transmission, glutamatergic (GO:0035249)5.33412122
9protein localization to synapse (GO:0035418)5.19241684
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.16912438
11positive regulation of dendritic spine morphogenesis (GO:0061003)5.16386716
12glutamate receptor signaling pathway (GO:0007215)5.14323927
13synaptic vesicle docking involved in exocytosis (GO:0016081)5.12631712
14axonal fasciculation (GO:0007413)5.02329664
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.95482758
16nerve growth factor signaling pathway (GO:0038180)4.83126311
17protein polyglutamylation (GO:0018095)4.79570272
18negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.75825530
19glutamate secretion (GO:0014047)4.74127878
20muscle cell fate commitment (GO:0042693)4.72222870
21neurotransmitter-gated ion channel clustering (GO:0072578)4.70459373
22central nervous system projection neuron axonogenesis (GO:0021952)4.69537466
23regulation of axon extension involved in axon guidance (GO:0048841)4.57221267
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.57170797
25regulation of glutamate receptor signaling pathway (GO:1900449)4.50384811
26tryptophan metabolic process (GO:0006568)4.41881228
27neuron-neuron synaptic transmission (GO:0007270)4.41586824
28neuronal action potential propagation (GO:0019227)4.41327672
29neuron recognition (GO:0008038)4.37790780
30DNA deamination (GO:0045006)4.34950456
31regulation of excitatory postsynaptic membrane potential (GO:0060079)4.31666568
32regulation of axon guidance (GO:1902667)4.28675905
33indolalkylamine metabolic process (GO:0006586)4.24744274
34regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.24292776
35regulation of vesicle fusion (GO:0031338)4.19067771
36postsynaptic membrane organization (GO:0001941)4.17373536
37positive regulation of vesicle fusion (GO:0031340)4.06882580
38fucose catabolic process (GO:0019317)4.06723922
39L-fucose metabolic process (GO:0042354)4.06723922
40L-fucose catabolic process (GO:0042355)4.06723922
41locomotory exploration behavior (GO:0035641)4.05773601
42regulation of postsynaptic membrane potential (GO:0060078)4.03762671
43head development (GO:0060322)4.03097274
44synaptic vesicle maturation (GO:0016188)4.02849517
45amine catabolic process (GO:0009310)4.02142602
46cellular biogenic amine catabolic process (GO:0042402)4.02142602
47urinary tract smooth muscle contraction (GO:0014848)3.98614575
48response to histamine (GO:0034776)3.97779569
49synaptic vesicle exocytosis (GO:0016079)3.97496885
50neuron cell-cell adhesion (GO:0007158)3.96887435
51axoneme assembly (GO:0035082)3.94454496
52G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.91486695
53regulation of chromatin binding (GO:0035561)3.90658805
54negative regulation of activin receptor signaling pathway (GO:0032926)3.90391504
55parturition (GO:0007567)3.89439695
56regulation of neuronal synaptic plasticity (GO:0048168)3.85891935
57presynaptic membrane assembly (GO:0097105)3.83416794
58regulation of dendritic spine morphogenesis (GO:0061001)3.81498944
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.78774024
60positive regulation of dendritic spine development (GO:0060999)3.77971426
61cellular response to ATP (GO:0071318)3.76985493
62nonmotile primary cilium assembly (GO:0035058)3.76707843
63regulation of synaptic vesicle transport (GO:1902803)3.73986877
64exploration behavior (GO:0035640)3.72252758
65regulation of cilium movement (GO:0003352)3.71903244
66neuron projection extension involved in neuron projection guidance (GO:1902284)3.69565136
67axon extension involved in axon guidance (GO:0048846)3.69565136
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.68672472
69gamma-aminobutyric acid signaling pathway (GO:0007214)3.68543951
70gonadal mesoderm development (GO:0007506)3.67521532
71long-term memory (GO:0007616)3.67123739
72epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.65313095
73behavioral defense response (GO:0002209)3.64322404
74behavioral fear response (GO:0001662)3.64322404
75cell proliferation in forebrain (GO:0021846)3.63227110
76cellular potassium ion homeostasis (GO:0030007)3.62955977
77mitotic cell cycle arrest (GO:0071850)3.61973553
78serotonin metabolic process (GO:0042428)3.61686090
79regulation of synaptic vesicle exocytosis (GO:2000300)3.59667727
80respiratory chain complex IV assembly (GO:0008535)3.57545600
81positive regulation of neurotransmitter secretion (GO:0001956)3.57506666
82skeletal muscle fiber development (GO:0048741)3.55493549
83cell communication by electrical coupling (GO:0010644)3.53381629
84response to gravity (GO:0009629)3.52638300
85central nervous system neuron axonogenesis (GO:0021955)3.52631300
86regulation of respiratory system process (GO:0044065)3.50505422
87cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.50226398
88regulation of glomerulus development (GO:0090192)3.47024064
89presynaptic membrane organization (GO:0097090)3.43291447
90membrane depolarization (GO:0051899)3.42169615
91positive regulation of catecholamine secretion (GO:0033605)3.38461187
92water-soluble vitamin biosynthetic process (GO:0042364)3.36918685
93glomerular visceral epithelial cell development (GO:0072015)3.34000723
94cerebellar Purkinje cell differentiation (GO:0021702)3.33553319
95positive regulation of fibroblast migration (GO:0010763)3.32463774
96primary amino compound metabolic process (GO:1901160)3.31327018
97membrane depolarization during action potential (GO:0086010)3.29970284
98cellular response to estradiol stimulus (GO:0071392)3.25618280
99regulation of memory T cell differentiation (GO:0043380)3.25571507
100cytochrome complex assembly (GO:0017004)3.24628562
101regulation of long-term neuronal synaptic plasticity (GO:0048169)3.24385848
102somite development (GO:0061053)3.22752145
103myotube cell development (GO:0014904)3.22505349
104regulation of dendritic spine development (GO:0060998)3.22198761
105regulation of synaptic plasticity (GO:0048167)3.21673680
106positive regulation of defense response to virus by host (GO:0002230)3.21505476
107positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.18205349
108positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.17628945
109kidney morphogenesis (GO:0060993)3.16077444
110fear response (GO:0042596)3.15387594
111regulation of synapse assembly (GO:0051963)3.14205290
112synaptic vesicle endocytosis (GO:0048488)3.11923983
113positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.10210078
114positive regulation of glomerulus development (GO:0090193)3.09976573
115aromatic amino acid family catabolic process (GO:0009074)3.08446694
116regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.05621418
117gamma-aminobutyric acid transport (GO:0015812)3.05567708
118vocalization behavior (GO:0071625)3.04848788
119myotube differentiation (GO:0014902)3.03801109
120axonemal dynein complex assembly (GO:0070286)3.03602909
121positive regulation of membrane potential (GO:0045838)3.02219291
122negative regulation of cell cycle arrest (GO:0071157)3.01890386
123cellular ketone body metabolic process (GO:0046950)2.99862309
124transmission of nerve impulse (GO:0019226)2.99584261
125regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.99545197
126long-term synaptic potentiation (GO:0060291)2.99508336
127positive regulation of mitochondrial fission (GO:0090141)2.99269256
128positive regulation of synapse maturation (GO:0090129)2.99261775
129ovulation cycle (GO:0042698)2.99028361
130synaptic transmission, cholinergic (GO:0007271)2.98592507
131negative regulation of appetite (GO:0032099)2.97478784
132negative regulation of response to food (GO:0032096)2.97478784
133auditory receptor cell stereocilium organization (GO:0060088)2.97065234
134negative regulation of reactive oxygen species metabolic process (GO:2000378)2.96870905
135regulation of respiratory gaseous exchange (GO:0043576)2.96765523
136regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.96285192
137indole-containing compound metabolic process (GO:0042430)2.95282605
138regulation of beta-amyloid formation (GO:1902003)2.94243766
139positive regulation of synapse assembly (GO:0051965)2.94136742
140benzene-containing compound metabolic process (GO:0042537)2.93795510
141regulation of clathrin-mediated endocytosis (GO:2000369)2.93396370
142response to pheromone (GO:0019236)2.93275148
143sulfate transmembrane transport (GO:1902358)2.93089649
144dendritic spine morphogenesis (GO:0060997)2.92563367
145positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.90934990
146glomerular epithelial cell development (GO:0072310)2.90863404
147epithelial cilium movement (GO:0003351)2.90466182
148regulation of microtubule-based movement (GO:0060632)2.89849331
149neuromuscular process controlling posture (GO:0050884)2.89528988
150cellular response to nerve growth factor stimulus (GO:1990090)2.88888070
151response to nerve growth factor (GO:1990089)2.88888070
152neuromuscular synaptic transmission (GO:0007274)2.88516498
153hypothalamus development (GO:0021854)2.86545270
154suckling behavior (GO:0001967)2.86271704
155positive regulation of glycoprotein biosynthetic process (GO:0010560)2.85221388
156pyrimidine ribonucleoside catabolic process (GO:0046133)2.85021383
157negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.84387065
158adaptation of signaling pathway (GO:0023058)2.83127649
159regulation of inositol phosphate biosynthetic process (GO:0010919)2.83117216
160calcium ion import (GO:0070509)2.81796884
161neurotransmitter secretion (GO:0007269)2.80059363
162detection of temperature stimulus (GO:0016048)2.79342507
163regulation of synapse organization (GO:0050807)2.79316202
164cellular response to exogenous dsRNA (GO:0071360)2.75309220
165spinal cord association neuron differentiation (GO:0021527)2.74011513
166detection of light stimulus involved in visual perception (GO:0050908)2.73172397
167detection of light stimulus involved in sensory perception (GO:0050962)2.73172397
168positive regulation of fatty acid oxidation (GO:0046321)2.73054502
169regulation of mitochondrial fission (GO:0090140)2.71835707
170lens fiber cell differentiation (GO:0070306)2.68532881
171sulfation (GO:0051923)2.68441172
172negative regulation of heart rate (GO:0010459)2.67981228
173cytidine metabolic process (GO:0046087)2.64874735
174cytidine catabolic process (GO:0006216)2.64874735
175cytidine deamination (GO:0009972)2.64874735
176cilium movement (GO:0003341)2.64840404
177negative regulation of telomere maintenance (GO:0032205)2.64301484
178brain morphogenesis (GO:0048854)2.63909227
179preassembly of GPI anchor in ER membrane (GO:0016254)2.63041869
180oxidative demethylation (GO:0070989)2.61757259
181ketone body metabolic process (GO:1902224)2.56026811
182sulfate transport (GO:0008272)2.55761378
183dentate gyrus development (GO:0021542)2.54506700
184response to testosterone (GO:0033574)2.53190759
185regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.53171259
186cornea development in camera-type eye (GO:0061303)2.51907804
187positive regulation by host of viral transcription (GO:0043923)2.51372889
188protein complex biogenesis (GO:0070271)2.51206281
189nephron tubule formation (GO:0072079)2.49259934
190striated muscle atrophy (GO:0014891)2.48148347
191pyrimidine nucleobase catabolic process (GO:0006208)2.47953855
192regulation of neurotransmitter uptake (GO:0051580)2.47343347
193motile cilium assembly (GO:0044458)2.46843314
194cellular anion homeostasis (GO:0030002)2.46059097
195regulation of gene silencing by RNA (GO:0060966)2.44015737
196regulation of posttranscriptional gene silencing (GO:0060147)2.44015737
197regulation of gene silencing by miRNA (GO:0060964)2.44015737

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.42449812
2GBX2_23144817_ChIP-Seq_PC3_Human5.03555860
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.62266457
4DROSHA_22980978_ChIP-Seq_HELA_Human2.71753852
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66596779
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.60236518
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58837159
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37412825
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35240017
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.21681774
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.20641682
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15677709
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15170958
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14951617
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12448838
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12448838
17REST_21632747_ChIP-Seq_MESCs_Mouse2.07172957
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06933287
19* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04708725
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02533928
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.99271349
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98591604
23* RARB_27405468_Chip-Seq_BRAIN_Mouse1.98051898
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94324243
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.92872341
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89530000
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88941433
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.87772629
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85364340
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80424769
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80277449
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.79794550
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79397176
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76541028
35FUS_26573619_Chip-Seq_HEK293_Human1.74185588
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68075648
37ERA_21632823_ChIP-Seq_H3396_Human1.67897969
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.66643972
39SMAD4_21799915_ChIP-Seq_A2780_Human1.64224843
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63915022
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63595220
42TAF15_26573619_Chip-Seq_HEK293_Human1.60303516
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57396194
44ETV2_25802403_ChIP-Seq_MESCs_Mouse1.55514226
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.54399390
46TP53_16413492_ChIP-PET_HCT116_Human1.52289276
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50668944
48VDR_22108803_ChIP-Seq_LS180_Human1.49996167
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48809642
50NANOG_20526341_ChIP-Seq_ESCs_Human1.46807186
51EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.46327770
52RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43635590
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43402759
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.42575098
55P68_20966046_ChIP-Seq_HELA_Human1.36288742
56P300_19829295_ChIP-Seq_ESCs_Human1.35501359
57AR_25329375_ChIP-Seq_VCAP_Human1.34575726
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.34527942
59FOXH1_21741376_ChIP-Seq_ESCs_Human1.34270076
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33788381
61ZNF274_21170338_ChIP-Seq_K562_Hela1.31892013
62E2F1_20622854_ChIP-Seq_HELA_Human1.30150578
63TAF2_19829295_ChIP-Seq_ESCs_Human1.29651084
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27914730
65TP53_22573176_ChIP-Seq_HFKS_Human1.27797531
66MYC_18940864_ChIP-ChIP_HL60_Human1.26604505
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26254851
68IGF1R_20145208_ChIP-Seq_DFB_Human1.25952655
69NCOR_22424771_ChIP-Seq_293T_Human1.24947790
70* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.23211276
71STAT3_23295773_ChIP-Seq_U87_Human1.23056221
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.22941479
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21397836
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.21188434
75* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20992226
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20660903
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.20561051
78ER_23166858_ChIP-Seq_MCF-7_Human1.20301530
79HOXB7_26014856_ChIP-Seq_BT474_Human1.19575295
80BCL6_27268052_Chip-Seq_Bcells_Human1.17594375
81ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14345977
82TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14088946
83TCF4_23295773_ChIP-Seq_U87_Human1.13200169
84AR_19668381_ChIP-Seq_PC3_Human1.13193082
85AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13153709
86SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12982938
87TP53_18474530_ChIP-ChIP_U2OS_Human1.12673525
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12132658
89IRF1_19129219_ChIP-ChIP_H3396_Human1.12111940
90CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09473965
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08286735
92LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08166259
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08159463
94PHF8_20622854_ChIP-Seq_HELA_Human1.07614483
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06748490
96MYC_19829295_ChIP-Seq_ESCs_Human1.06521338
97TP53_20018659_ChIP-ChIP_R1E_Mouse1.06008754
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.05612204
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04190438
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03709900
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03662913
102BCAT_22108803_ChIP-Seq_LS180_Human1.03351214
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.03008976
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02275138
105OCT4_20526341_ChIP-Seq_ESCs_Human1.02260029
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00377766
107RAC3_21632823_ChIP-Seq_H3396_Human1.00197049
108AHR_22903824_ChIP-Seq_MCF-7_Human1.00121024
109RNF2_27304074_Chip-Seq_NSC_Mouse1.00078602
110NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98701798
111TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98397050
112* P53_21459846_ChIP-Seq_SAOS-2_Human0.98118644
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97753394
114YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97174226
115CTCF_20526341_ChIP-Seq_ESCs_Human0.97119007
116ELF1_20517297_ChIP-Seq_JURKAT_Human0.96971697
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96622248
118KDM2B_26808549_Chip-Seq_REH_Human0.96285319
119GATA3_21878914_ChIP-Seq_MCF-7_Human0.96244057
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96118228
121P300_27268052_Chip-Seq_Bcells_Human0.96040555
122POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95961965
123EP300_21415370_ChIP-Seq_HL-1_Mouse0.95811704
124OCT4_19829295_ChIP-Seq_ESCs_Human0.95311167
125MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95239945
126PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95142912
127AR_21572438_ChIP-Seq_LNCaP_Human0.94853132
128ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94566622
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94086247
130CTCF_27219007_Chip-Seq_Bcells_Human0.93922318
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93849064
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93144552
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92760026
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92729075
135MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92607008
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91419931
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91170521
138CBP_20019798_ChIP-Seq_JUKART_Human0.91170521
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.91106109
140SMAD_19615063_ChIP-ChIP_OVARY_Human0.90733927
141* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88934467
142* FOXA1_25329375_ChIP-Seq_VCAP_Human0.88934467
143MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88788472
144RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88640733
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88591690
146RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88521640
147DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88064253
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88063230
149RUNX2_22187159_ChIP-Seq_PCA_Human0.88007134
150WDR5_24793694_ChIP-Seq_LNCAP_Human0.87590739
151TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87433797
152FLI1_21867929_ChIP-Seq_CD8_Mouse0.86697978
153ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86513671
154OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85817955
155VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84464948

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.66823097
2MP0003880_abnormal_central_pattern6.63224847
3MP0002735_abnormal_chemical_nociception4.44699025
4MP0003635_abnormal_synaptic_transmissio3.70728541
5MP0010234_abnormal_vibrissa_follicle3.68333171
6MP0001968_abnormal_touch/_nociception3.60123917
7MP0002736_abnormal_nociception_after3.30282866
8MP0002876_abnormal_thyroid_physiology3.22293454
9MP0009745_abnormal_behavioral_response3.01711723
10MP0002063_abnormal_learning/memory/cond2.90043649
11MP0003283_abnormal_digestive_organ2.88760577
12MP0008875_abnormal_xenobiotic_pharmacok2.86338021
13MP0001501_abnormal_sleep_pattern2.82333167
14MP0002064_seizures2.79066753
15MP0002822_catalepsy2.68845572
16MP0003011_delayed_dark_adaptation2.68712345
17MP0006292_abnormal_olfactory_placode2.44409511
18MP0002572_abnormal_emotion/affect_behav2.43091092
19MP0005646_abnormal_pituitary_gland2.30708423
20MP0002653_abnormal_ependyma_morphology2.28202806
21MP0002272_abnormal_nervous_system2.28008300
22MP0004381_abnormal_hair_follicle2.25109024
23MP0002138_abnormal_hepatobiliary_system2.12412868
24MP0008877_abnormal_DNA_methylation2.09749111
25MP0002234_abnormal_pharynx_morphology2.06381328
26MP0004270_analgesia1.96811627
27MP0003879_abnormal_hair_cell1.95894682
28MP0003195_calcinosis1.86925212
29MP0003122_maternal_imprinting1.85859914
30MP0004142_abnormal_muscle_tone1.84380057
31MP0000631_abnormal_neuroendocrine_gland1.81782766
32MP0003646_muscle_fatigue1.81578841
33MP0001440_abnormal_grooming_behavior1.75949621
34MP0002733_abnormal_thermal_nociception1.74924316
35MP0009046_muscle_twitch1.70877709
36MP0004134_abnormal_chest_morphology1.70797506
37MP0001984_abnormal_olfaction1.69634134
38MP0002067_abnormal_sensory_capabilities1.67556105
39MP0000955_abnormal_spinal_cord1.65859371
40MP0005377_hearing/vestibular/ear_phenot1.63795527
41MP0003878_abnormal_ear_physiology1.63795527
42MP0008872_abnormal_physiological_respon1.61656912
43MP0004858_abnormal_nervous_system1.59200421
44MP0001970_abnormal_pain_threshold1.58484602
45MP0001502_abnormal_circadian_rhythm1.55055815
46MP0002734_abnormal_mechanical_nocicepti1.52900373
47MP0004133_heterotaxia1.51575105
48MP0002184_abnormal_innervation1.45527230
49MP0005670_abnormal_white_adipose1.44269039
50MP0006072_abnormal_retinal_apoptosis1.41885414
51MP0001486_abnormal_startle_reflex1.40380973
52MP0001905_abnormal_dopamine_level1.38520132
53MP0000778_abnormal_nervous_system1.36794395
54MP0004811_abnormal_neuron_physiology1.31497185
55MP0008789_abnormal_olfactory_epithelium1.30592180
56MP0003787_abnormal_imprinting1.26421479
57MP0002837_dystrophic_cardiac_calcinosis1.26321503
58MP0008569_lethality_at_weaning1.25793902
59MP0005423_abnormal_somatic_nervous1.25683025
60MP0002163_abnormal_gland_morphology1.24973655
61MP0002254_reproductive_system_inflammat1.23479302
62MP0002249_abnormal_larynx_morphology1.23258565
63MP0000372_irregular_coat_pigmentation1.23033973
64MP0005075_abnormal_melanosome_morpholog1.22982087
65MP0002102_abnormal_ear_morphology1.22880926
66MP0001542_abnormal_bone_strength1.21745556
67MP0000026_abnormal_inner_ear1.21505860
68MP0003329_amyloid_beta_deposits1.19495898
69MP0002882_abnormal_neuron_morphology1.17886251
70MP0005645_abnormal_hypothalamus_physiol1.16887661
71MP0005220_abnormal_exocrine_pancreas1.15467826
72MP0001346_abnormal_lacrimal_gland1.14372192
73MP0004885_abnormal_endolymph1.11115099
74MP0002066_abnormal_motor_capabilities/c1.10433110
75MP0005389_reproductive_system_phenotype1.07736535
76MP0002557_abnormal_social/conspecific_i1.05668865
77MP0005253_abnormal_eye_physiology1.03460180
78MP0008995_early_reproductive_senescence1.02329058
79MP0000749_muscle_degeneration1.01655762
80MP0002160_abnormal_reproductive_system1.01582701
81MP0003121_genomic_imprinting1.01130773
82MP0001986_abnormal_taste_sensitivity1.00813110
83MP0000750_abnormal_muscle_regeneration1.00603081
84MP0000733_abnormal_muscle_development1.00451275
85MP0005671_abnormal_response_to0.99885974
86MP0002928_abnormal_bile_duct0.99418669
87MP0001348_abnormal_lacrimal_gland0.98600969
88MP0001188_hyperpigmentation0.97443232
89MP0000681_abnormal_thyroid_gland0.97184679
90MP0002938_white_spotting0.97130788
91MP0002108_abnormal_muscle_morphology0.96463115
92MP0004510_myositis0.95535197
93MP0009780_abnormal_chondrocyte_physiolo0.95187749
94MP0005195_abnormal_posterior_eye0.94704366
95MP0000049_abnormal_middle_ear0.93039586
96MP0000427_abnormal_hair_cycle0.91969946
97MP0003137_abnormal_impulse_conducting0.90830595
98MP0001299_abnormal_eye_distance/0.89567996
99MP0005394_taste/olfaction_phenotype0.88956328
100MP0005499_abnormal_olfactory_system0.88956328
101MP0005360_urolithiasis0.88895788
102MP0003632_abnormal_nervous_system0.86318284
103MP0002909_abnormal_adrenal_gland0.85478651
104MP0000467_abnormal_esophagus_morphology0.84735766
105MP0002751_abnormal_autonomic_nervous0.83132294
106MP0000678_abnormal_parathyroid_gland0.82273935
107MP0006054_spinal_hemorrhage0.81735570
108MP0001529_abnormal_vocalization0.81729054
109MP0005448_abnormal_energy_balance0.81702306
110MP0003075_altered_response_to0.81075928
111MP0001919_abnormal_reproductive_system0.80808678
112MP0002752_abnormal_somatic_nervous0.79784475
113MP0001963_abnormal_hearing_physiology0.78205264
114MP0008775_abnormal_heart_ventricle0.77209296
115MP0004145_abnormal_muscle_electrophysio0.74829659
116MP0010678_abnormal_skin_adnexa0.74592505
117MP0003633_abnormal_nervous_system0.72766512
118MP0002152_abnormal_brain_morphology0.72186646
119MP0003631_nervous_system_phenotype0.71760170
120MP0000569_abnormal_digit_pigmentation0.71419784
121MP0005623_abnormal_meninges_morphology0.71297531
122MP0002229_neurodegeneration0.70999573
123MP0005171_absent_coat_pigmentation0.70105891
124MP0002269_muscular_atrophy0.69378615
125MP0003690_abnormal_glial_cell0.68981687
126MP0000751_myopathy0.66421544
127MP0003938_abnormal_ear_development0.63689585
128MP0003045_fibrosis0.62936749
129MP0008874_decreased_physiological_sensi0.62819096
130MP0005551_abnormal_eye_electrophysiolog0.62639860
131MP0010386_abnormal_urinary_bladder0.62198661
132MP0000534_abnormal_ureter_morphology0.61024680
133MP0002069_abnormal_eating/drinking_beha0.60874447
134MP0001765_abnormal_ion_homeostasis0.59894084
135MP0001177_atelectasis0.59871511
136MP0004215_abnormal_myocardial_fiber0.59729114
137MP0004742_abnormal_vestibular_system0.59240740
138MP0006276_abnormal_autonomic_nervous0.58627083
139MP0005310_abnormal_salivary_gland0.58300987
140MP0005595_abnormal_vascular_smooth0.57571280
141MP0002090_abnormal_vision0.56697672
142MP0005367_renal/urinary_system_phenotyp0.56551475
143MP0000516_abnormal_urinary_system0.56551475
144MP0005386_behavior/neurological_phenoty0.56406331
145MP0004924_abnormal_behavior0.56406331
146MP0000747_muscle_weakness0.55530436
147MP0001485_abnormal_pinna_reflex0.52813085
148MP0004085_abnormal_heartbeat0.52231459
149MP0000759_abnormal_skeletal_muscle0.51439682
150MP0003698_abnormal_male_reproductive0.51384102
151MP0004043_abnormal_pH_regulation0.50269736
152MP0003123_paternal_imprinting0.48021778
153MP0002233_abnormal_nose_morphology0.47865411

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.10060965
2Myokymia (HP:0002411)4.81838525
3Absent rod-and cone-mediated responses on ERG (HP:0007688)4.58538578
4Focal seizures (HP:0007359)4.51321562
5Febrile seizures (HP:0002373)4.30986906
6Reduced antithrombin III activity (HP:0001976)4.13124545
7Abnormal rod and cone electroretinograms (HP:0008323)4.07030504
8Aplasia involving bones of the upper limbs (HP:0009823)4.00565169
9Aplasia of the phalanges of the hand (HP:0009802)4.00565169
10Aplasia involving bones of the extremities (HP:0009825)4.00565169
11Molar tooth sign on MRI (HP:0002419)3.77503298
12Abnormality of midbrain morphology (HP:0002418)3.77503298
13Dysdiadochokinesis (HP:0002075)3.73923344
14Genetic anticipation (HP:0003743)3.70172000
15Pancreatic cysts (HP:0001737)3.67931257
16Atonic seizures (HP:0010819)3.63633400
17Epileptic encephalopathy (HP:0200134)3.59491088
18Pancreatic fibrosis (HP:0100732)3.55170367
19Dialeptic seizures (HP:0011146)3.53385489
20Absence seizures (HP:0002121)3.46078120
21Hypoplastic nipples (HP:0002557)3.32079962
22Exotropia (HP:0000577)3.31720092
23Cutaneous finger syndactyly (HP:0010554)3.20061468
24Distal lower limb amyotrophy (HP:0008944)3.19841096
25Protruding tongue (HP:0010808)3.13462145
26Oligodactyly (hands) (HP:0001180)3.10728017
27Nephronophthisis (HP:0000090)3.09639903
283-Methylglutaconic aciduria (HP:0003535)3.05158331
29True hermaphroditism (HP:0010459)3.04696349
30Broad-based gait (HP:0002136)3.01030388
31Obstructive sleep apnea (HP:0002870)3.00285284
32Methylmalonic acidemia (HP:0002912)2.99817749
33Abnormality of macular pigmentation (HP:0008002)2.98755764
34Anterior segment dysgenesis (HP:0007700)2.95228616
35Type 2 muscle fiber atrophy (HP:0003554)2.94613449
36Agitation (HP:0000713)2.94306556
37Postural instability (HP:0002172)2.94305274
38Hemiparesis (HP:0001269)2.93135806
39Abnormal respiratory epithelium morphology (HP:0012253)2.91678533
40Abnormal respiratory motile cilium morphology (HP:0005938)2.91678533
41Elevated erythrocyte sedimentation rate (HP:0003565)2.88590349
42Nonprogressive disorder (HP:0003680)2.88005029
43Aplasia/Hypoplasia of the spleen (HP:0010451)2.87325488
44Abnormality of the renal medulla (HP:0100957)2.82526399
45Lower limb amyotrophy (HP:0007210)2.81007117
46Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.79133897
47Calf muscle hypertrophy (HP:0008981)2.75854315
48Generalized tonic-clonic seizures (HP:0002069)2.71610809
49Cystic liver disease (HP:0006706)2.70989802
50Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.70032934
51Bundle branch block (HP:0011710)2.70023597
52Gonadotropin excess (HP:0000837)2.68345928
53Ulnar claw (HP:0001178)2.65912636
54Congenital stationary night blindness (HP:0007642)2.56179329
55Lower limb asymmetry (HP:0100559)2.56160266
56Annular pancreas (HP:0001734)2.55927612
57Muscle fiber atrophy (HP:0100295)2.55701192
58Dysmetria (HP:0001310)2.54720652
59Cutaneous syndactyly (HP:0012725)2.54337502
60Hypoventilation (HP:0002791)2.53438471
61Hypoproteinemia (HP:0003075)2.51462485
62Abnormal number of erythroid precursors (HP:0012131)2.48992599
63Muscle hypertrophy of the lower extremities (HP:0008968)2.45926775
64Abnormality of DNA repair (HP:0003254)2.44815003
65Abnormal ciliary motility (HP:0012262)2.43681455
66Pendular nystagmus (HP:0012043)2.43300411
67Truncal ataxia (HP:0002078)2.42959793
68Confusion (HP:0001289)2.42420471
69Supernumerary nipples (HP:0002558)2.42179552
70Asplenia (HP:0001746)2.41133846
71Attenuation of retinal blood vessels (HP:0007843)2.39318264
72Ventricular arrhythmia (HP:0004308)2.38969606
73Dynein arm defect of respiratory motile cilia (HP:0012255)2.35371999
74Absent/shortened dynein arms (HP:0200106)2.35371999
75Medial flaring of the eyebrow (HP:0010747)2.35360155
76Gaze-evoked nystagmus (HP:0000640)2.34710133
77Hyperactive renin-angiotensin system (HP:0000841)2.32917086
78Porencephaly (HP:0002132)2.32694437
79Abnormality of cells of the erythroid lineage (HP:0012130)2.31193718
80Bony spicule pigmentary retinopathy (HP:0007737)2.30745951
81Difficulty climbing stairs (HP:0003551)2.30295553
82Upper limb muscle weakness (HP:0003484)2.29587405
83Popliteal pterygium (HP:0009756)2.28136046
84Sclerocornea (HP:0000647)2.27893927
85Torticollis (HP:0000473)2.27869339
86Weak cry (HP:0001612)2.27611642
87Abnormality of alanine metabolism (HP:0010916)2.26258191
88Hyperalaninemia (HP:0003348)2.26258191
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26258191
90Abnormal pancreas size (HP:0012094)2.25440709
91Chorioretinal atrophy (HP:0000533)2.25376712
92Tubulointerstitial nephritis (HP:0001970)2.24732916
93Atrial fibrillation (HP:0005110)2.22860401
94Abnormality of dental color (HP:0011073)2.21412441
95Shoulder girdle muscle weakness (HP:0003547)2.19774075
96Hypoplasia of the uterus (HP:0000013)2.18618443
97Decreased central vision (HP:0007663)2.18103832
98Visual hallucinations (HP:0002367)2.17105149
99Supranuclear gaze palsy (HP:0000605)2.16398300
100Primary atrial arrhythmia (HP:0001692)2.15577010
101Abnormal respiratory motile cilium physiology (HP:0012261)2.14714121
102Homocystinuria (HP:0002156)2.13645064
103Abnormality of homocysteine metabolism (HP:0010919)2.13645064
104Turricephaly (HP:0000262)2.13398539
105Syncope (HP:0001279)2.12577068
106Global brain atrophy (HP:0002283)2.11103956
107Abnormal EKG (HP:0003115)2.10575672
108Hypoplastic ischia (HP:0003175)2.10025573
109Abnormality of the renal collecting system (HP:0004742)2.09685587
110Horseshoe kidney (HP:0000085)2.08623307
111Thoracic kyphosis (HP:0002942)2.07311080
112Distal lower limb muscle weakness (HP:0009053)2.07075287
113Pointed chin (HP:0000307)2.06857552
114Subaortic stenosis (HP:0001682)2.06060267
115Abnormality of the left ventricular outflow tract (HP:0011103)2.06060267
116Adrenal hypoplasia (HP:0000835)2.05720471
117Disproportionate short-trunk short stature (HP:0003521)2.05494533
118Abnormality of the calf musculature (HP:0001430)2.04680662
119Pigmentary retinal degeneration (HP:0001146)2.03296177
120Fetal akinesia sequence (HP:0001989)2.01858630
121Hyperventilation (HP:0002883)2.01835668
122Impaired vibration sensation in the lower limbs (HP:0002166)2.00527921
123Abnormality of the renal cortex (HP:0011035)2.00488604
124Keratoconus (HP:0000563)2.00247178
125Increased corneal curvature (HP:0100692)2.00247178
126Pelvic girdle muscle weakness (HP:0003749)2.00052749
127Supraventricular tachycardia (HP:0004755)1.98509410
128Methylmalonic aciduria (HP:0012120)1.98422150
129Breast aplasia (HP:0100783)1.98347360
130Anosmia (HP:0000458)1.98317216
131Cerebellar dysplasia (HP:0007033)1.98272436
132Hemiplegia (HP:0002301)1.97948283
133Type I transferrin isoform profile (HP:0003642)1.96788876
134Hyperkalemia (HP:0002153)1.96423629
135Abolished electroretinogram (ERG) (HP:0000550)1.95108174
136Congenital sensorineural hearing impairment (HP:0008527)1.94736311
137Anencephaly (HP:0002323)1.94357570
138Type II lissencephaly (HP:0007260)1.94021703
139Vaginal atresia (HP:0000148)1.92716467
140Fair hair (HP:0002286)1.92385855
141Clumsiness (HP:0002312)1.92151565
142Supraventricular arrhythmia (HP:0005115)1.91708169
143Increased IgE level (HP:0003212)1.91164870
144Hyperthyroidism (HP:0000836)1.90831237
145Concave nail (HP:0001598)1.90655631
146Fatigable weakness (HP:0003473)1.89610953
147Abnormality of the neuromuscular junction (HP:0003398)1.89610953
148Severe muscular hypotonia (HP:0006829)1.88782565
149Shawl scrotum (HP:0000049)1.88391665
150Short nail (HP:0001799)1.88388262
151Genital tract atresia (HP:0001827)1.86897068
152Poor eye contact (HP:0000817)1.86497030
153Bradycardia (HP:0001662)1.86170898
154Gait imbalance (HP:0002141)1.84679316
155Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.84542288
156Sleep apnea (HP:0010535)1.84532278
157Incomplete penetrance (HP:0003829)1.84389172
158Focal dystonia (HP:0004373)1.83835162
159Enlarged epiphyses (HP:0010580)1.82648491
160Insomnia (HP:0100785)1.82614569
161Generalized hypopigmentation of hair (HP:0011358)1.80880977
162Thyroid-stimulating hormone excess (HP:0002925)1.79725338
163Increased circulating renin level (HP:0000848)1.78579195
164Congenital primary aphakia (HP:0007707)1.77030588
165Progressive cerebellar ataxia (HP:0002073)1.76981604
166Flat cornea (HP:0007720)1.76392564
167Sudden death (HP:0001699)1.76337994
168Nephrogenic diabetes insipidus (HP:0009806)1.75631811
169Abnormality of the musculature of the pelvis (HP:0001469)1.75342974
170Abnormality of the hip-girdle musculature (HP:0001445)1.75342974
171Abnormality of the lower motor neuron (HP:0002366)1.74965125
172Ectopic kidney (HP:0000086)1.74620543
173Chronic bronchitis (HP:0004469)1.73987742
174Mildly elevated creatine phosphokinase (HP:0008180)1.73714210
175Duplicated collecting system (HP:0000081)1.73691331
176Lissencephaly (HP:0001339)1.73326209
177Stereotypic behavior (HP:0000733)1.72843717
178Double outlet right ventricle (HP:0001719)1.72391820
179Congenital malformation of the right heart (HP:0011723)1.72391820
180Absent thumb (HP:0009777)1.72128867
181Optic nerve coloboma (HP:0000588)1.69663024
182Short femoral neck (HP:0100864)1.69280508
183Renal dysplasia (HP:0000110)1.68887765
184Furrowed tongue (HP:0000221)1.67273987
185Oligohydramnios (HP:0001562)1.67057977
186Pachygyria (HP:0001302)1.67047566
187Anomalous pulmonary venous return (HP:0010772)1.65837981
188Synostosis of carpal bones (HP:0005048)1.65726344
189Hepatocellular necrosis (HP:0001404)1.64781084
190Decreased circulating renin level (HP:0003351)1.63268913
191Impaired smooth pursuit (HP:0007772)1.60608709

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK8.73688244
2NTRK37.47668232
3EPHA45.32506337
4FRK3.94972039
5PRPF4B3.62547692
6TLK13.34684515
7ADRBK22.86804885
8EPHA32.53294666
9MAP3K92.52998346
10STK162.48819856
11MAPKAPK32.45709019
12MAP3K112.22959676
13BMPR1B2.16857961
14FGFR22.12585963
15NLK2.11547979
16TAOK22.09210082
17DDR22.02825053
18CAMKK21.92359373
19BRD41.89994363
20CSNK1A1L1.82403416
21TAOK31.78310660
22MAP4K21.77094300
23STK38L1.72607175
24GRK11.68606861
25WNK41.67238281
26CSNK1G31.66815626
27MAP4K11.65025855
28MAP3K141.64992244
29STK381.64132610
30NTRK11.61352952
31DAPK21.55079131
32TNK21.48689485
33MAP2K71.42697660
34TYRO31.41555390
35TAOK11.40786153
36WNK31.33241082
37CAMK11.27605237
38TXK1.25621333
39CSNK1G11.24446996
40SIK31.22588529
41INSRR1.18311978
42PRKCI1.09107524
43KSR21.04992742
44MAPK131.04453931
45CAMKK11.03340832
46EIF2AK31.03059675
47ITK1.02514665
48MAP3K131.01883732
49PASK1.00820607
50CAMK1D1.00157888
51KSR10.98654029
52SCYL20.98392705
53DAPK10.98234929
54MAP3K40.96712855
55PAK60.92455649
56CAMK2A0.90634676
57TRPM70.89449232
58AKT30.88745384
59MARK20.88196887
60MUSK0.87681563
61PRKD20.86856009
62FER0.84191359
63ARAF0.81786562
64FES0.80026969
65DYRK20.79243450
66CAMK40.78232484
67CDC42BPA0.75079488
68CAMK2B0.74169066
69SIK20.73637336
70PLK20.72645966
71EIF2AK10.72423512
72ERBB20.72152988
73CDK30.71803735
74MAP3K70.71650508
75PTK2B0.70539939
76MATK0.69510167
77MAP2K20.68707272
78MARK10.68514569
79NTRK20.67166468
80CDK80.67009115
81PDGFRA0.63410983
82MAPK150.62959763
83MAP3K10.61659659
84CASK0.60944425
85PRKCG0.60869182
86CDK50.60686670
87BLK0.56883491
88BCKDK0.56689543
89STK240.56285033
90ZAK0.56208101
91MST40.56133322
92TGFBR10.55381882
93CSNK1A10.53909550
94GRK70.50812841
95MINK10.48869734
96CAMK2D0.48129367
97HIPK20.47265884
98BRSK20.47160731
99ADRBK10.47081383
100EIF2AK20.46773939
101SGK10.45030818
102PINK10.44040928
103LIMK10.42199095
104PKN10.42189185
105NUAK10.40460117
106CSNK1D0.39851686
107CHUK0.38921564
108CDK150.38690605
109PRKCQ0.38202622
110CDK180.38027466
111STK110.37932497
112JAK10.37845148
113LATS10.37440407
114GRK50.36153488
115LCK0.35306600
116CDK70.34884549
117PHKG10.34832363
118PHKG20.34832363
119PRKD10.34763073
120MAP2K40.34171130
121IKBKB0.33925364
122MOS0.32881904
123BRSK10.31076499
124CAMK1G0.30469836
125FLT30.30389641
126IRAK10.30174907
127CDK11A0.30171889
128BRAF0.29769504
129ATR0.29165055
130ALK0.28876598
131SIK10.27833711
132PTK60.26823867
133ABL10.26115696
134RPS6KA30.26027532
135CDK140.25838622
136CAMK2G0.25769109
137PRKACA0.25491214
138PRKCA0.25029317
139PAK30.24874632
140EPHB10.23288719
141FGFR40.23177400
142PRKCH0.22833472
143PRKCB0.22267876
144RAF10.21855874
145HCK0.21797487
146PRKG10.21102312
147MAP2K10.19525423
148DAPK30.19127958
149DYRK1A0.18529132
150PRKD30.18170117
151PRKCE0.17575383
152MAP2K60.17122280
153GSK3B0.16481225
154PDPK10.15670408
155CSNK1E0.15387424
156CDK120.15187084
157OXSR10.14422114
158PRKAA10.14103590
159PRKDC0.13796699
160CSNK1G20.13088599
161PRKACB0.11950646

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002326.20362175
2Nicotine addiction_Homo sapiens_hsa050335.00755777
3Long-term potentiation_Homo sapiens_hsa047203.29956313
4Glutamatergic synapse_Homo sapiens_hsa047243.27114165
5Amphetamine addiction_Homo sapiens_hsa050313.02019494
6Linoleic acid metabolism_Homo sapiens_hsa005912.99020880
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.87191458
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82553052
9Phototransduction_Homo sapiens_hsa047442.75303212
10Circadian entrainment_Homo sapiens_hsa047132.63121314
11Synaptic vesicle cycle_Homo sapiens_hsa047212.57169593
12Olfactory transduction_Homo sapiens_hsa047402.55930897
13Morphine addiction_Homo sapiens_hsa050322.51926693
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.48119049
15GABAergic synapse_Homo sapiens_hsa047272.27657231
16Taste transduction_Homo sapiens_hsa047422.22760925
17Regulation of autophagy_Homo sapiens_hsa041402.05451250
18Calcium signaling pathway_Homo sapiens_hsa040201.98933331
19Tryptophan metabolism_Homo sapiens_hsa003801.93347549
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88719066
21Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.79066780
22Salivary secretion_Homo sapiens_hsa049701.77194112
23Renin secretion_Homo sapiens_hsa049241.67850500
24Axon guidance_Homo sapiens_hsa043601.67316046
25Oxytocin signaling pathway_Homo sapiens_hsa049211.66636279
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66463446
27Insulin secretion_Homo sapiens_hsa049111.65034296
28Dopaminergic synapse_Homo sapiens_hsa047281.61765829
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61699414
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61227382
31Nitrogen metabolism_Homo sapiens_hsa009101.55505823
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54167560
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.53568270
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52470038
35Serotonergic synapse_Homo sapiens_hsa047261.49158476
36VEGF signaling pathway_Homo sapiens_hsa043701.47184512
37Oxidative phosphorylation_Homo sapiens_hsa001901.44028819
38Arginine biosynthesis_Homo sapiens_hsa002201.41617380
39Circadian rhythm_Homo sapiens_hsa047101.39607518
40Long-term depression_Homo sapiens_hsa047301.38319895
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.37110681
42Basal cell carcinoma_Homo sapiens_hsa052171.33823685
43Ovarian steroidogenesis_Homo sapiens_hsa049131.33376924
44Cholinergic synapse_Homo sapiens_hsa047251.32232796
45Chemical carcinogenesis_Homo sapiens_hsa052041.32107624
46Collecting duct acid secretion_Homo sapiens_hsa049661.32035212
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29351931
48Cocaine addiction_Homo sapiens_hsa050301.24587173
49Ribosome_Homo sapiens_hsa030101.23517458
50One carbon pool by folate_Homo sapiens_hsa006701.21134777
51Hedgehog signaling pathway_Homo sapiens_hsa043401.19455014
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18914991
53ErbB signaling pathway_Homo sapiens_hsa040121.16643383
54Graft-versus-host disease_Homo sapiens_hsa053321.14998768
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14727169
56Primary immunodeficiency_Homo sapiens_hsa053401.14125868
57Gastric acid secretion_Homo sapiens_hsa049711.13023630
58cAMP signaling pathway_Homo sapiens_hsa040241.09439846
59Butanoate metabolism_Homo sapiens_hsa006501.08931667
60Dilated cardiomyopathy_Homo sapiens_hsa054141.07946483
61Fanconi anemia pathway_Homo sapiens_hsa034601.07377563
62Glioma_Homo sapiens_hsa052141.07195756
63Arachidonic acid metabolism_Homo sapiens_hsa005901.04831765
64Type II diabetes mellitus_Homo sapiens_hsa049301.02170888
65GnRH signaling pathway_Homo sapiens_hsa049121.01957542
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00266647
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99962534
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96341799
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93873286
70Parkinsons disease_Homo sapiens_hsa050120.93193117
71Propanoate metabolism_Homo sapiens_hsa006400.92915083
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92520320
73RNA polymerase_Homo sapiens_hsa030200.92453850
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87889090
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.87248288
76Type I diabetes mellitus_Homo sapiens_hsa049400.84970192
77Vibrio cholerae infection_Homo sapiens_hsa051100.83628607
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.82774880
79MAPK signaling pathway_Homo sapiens_hsa040100.79615537
80Glucagon signaling pathway_Homo sapiens_hsa049220.79502147
81Peroxisome_Homo sapiens_hsa041460.78784124
82Estrogen signaling pathway_Homo sapiens_hsa049150.78618975
83Basal transcription factors_Homo sapiens_hsa030220.75686635
84Choline metabolism in cancer_Homo sapiens_hsa052310.74352590
85Autoimmune thyroid disease_Homo sapiens_hsa053200.74254610
86Allograft rejection_Homo sapiens_hsa053300.73530516
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.71815626
88Wnt signaling pathway_Homo sapiens_hsa043100.71127053
89Alzheimers disease_Homo sapiens_hsa050100.69149853
90Fat digestion and absorption_Homo sapiens_hsa049750.67909859
91Melanoma_Homo sapiens_hsa052180.64866624
92T cell receptor signaling pathway_Homo sapiens_hsa046600.64214323
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.64139481
94Melanogenesis_Homo sapiens_hsa049160.63410968
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62887565
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62885421
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62618811
98Huntingtons disease_Homo sapiens_hsa050160.62314510
99Selenocompound metabolism_Homo sapiens_hsa004500.62278563
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.61786711
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60801004
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59890340
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.59619887
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58606458
105Ras signaling pathway_Homo sapiens_hsa040140.58486411
106Homologous recombination_Homo sapiens_hsa034400.58054339
107ABC transporters_Homo sapiens_hsa020100.57878327
108Pancreatic secretion_Homo sapiens_hsa049720.56140851
109beta-Alanine metabolism_Homo sapiens_hsa004100.54379544
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53181763
111Fatty acid elongation_Homo sapiens_hsa000620.52098507
112Pyruvate metabolism_Homo sapiens_hsa006200.52080425
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51992600
114Thyroid cancer_Homo sapiens_hsa052160.51234004
115Cardiac muscle contraction_Homo sapiens_hsa042600.50993294
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49974764
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49712584
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49327215
119Notch signaling pathway_Homo sapiens_hsa043300.47278240
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47267134
121Endometrial cancer_Homo sapiens_hsa052130.46804581
122Thyroid hormone synthesis_Homo sapiens_hsa049180.46305221
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46004582
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46001737
125Asthma_Homo sapiens_hsa053100.45009790
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43718595
127Sphingolipid metabolism_Homo sapiens_hsa006000.43354884
128RNA degradation_Homo sapiens_hsa030180.40614374
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40569406
130Retinol metabolism_Homo sapiens_hsa008300.40205993
131Chemokine signaling pathway_Homo sapiens_hsa040620.39282668
132Purine metabolism_Homo sapiens_hsa002300.38407414
133Mineral absorption_Homo sapiens_hsa049780.37481100
134Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36928472
135Gap junction_Homo sapiens_hsa045400.36239705
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.35731704
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35653358
138Oocyte meiosis_Homo sapiens_hsa041140.35152684
139Prion diseases_Homo sapiens_hsa050200.34168949
140Arginine and proline metabolism_Homo sapiens_hsa003300.33702251
141Ether lipid metabolism_Homo sapiens_hsa005650.32057054
142Bile secretion_Homo sapiens_hsa049760.31754243
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28801704
144Glycerolipid metabolism_Homo sapiens_hsa005610.27087660
145Dorso-ventral axis formation_Homo sapiens_hsa043200.26628459
146Rap1 signaling pathway_Homo sapiens_hsa040150.26181428
147Insulin signaling pathway_Homo sapiens_hsa049100.25817707
148Lysine degradation_Homo sapiens_hsa003100.23483147
149Histidine metabolism_Homo sapiens_hsa003400.22888735
150N-Glycan biosynthesis_Homo sapiens_hsa005100.22292585
151Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21113274
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20898433
153Neurotrophin signaling pathway_Homo sapiens_hsa047220.18480725
154ECM-receptor interaction_Homo sapiens_hsa045120.16884542
155Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16117614
156Alcoholism_Homo sapiens_hsa050340.16110015
157Adipocytokine signaling pathway_Homo sapiens_hsa049200.14930177
158Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14916202

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