NTNG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.72822831
2neuron cell-cell adhesion (GO:0007158)5.61002234
3vocalization behavior (GO:0071625)5.46806081
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.25760276
5behavioral response to nicotine (GO:0035095)5.24569315
6protein localization to synapse (GO:0035418)5.07006938
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.97950807
8synaptic vesicle exocytosis (GO:0016079)4.84631126
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.82925180
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.81502846
11regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.78871871
12glutamate receptor signaling pathway (GO:0007215)4.67062268
13glutamate secretion (GO:0014047)4.39398351
14regulation of synaptic vesicle exocytosis (GO:2000300)4.35406916
15regulation of glutamate receptor signaling pathway (GO:1900449)4.34335852
16neuronal action potential propagation (GO:0019227)4.22154620
17synaptic vesicle maturation (GO:0016188)4.21278526
18synaptic transmission, glutamatergic (GO:0035249)4.20684721
19G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.18767746
20cell proliferation in forebrain (GO:0021846)4.18362583
21neuron recognition (GO:0008038)4.16697834
22gamma-aminobutyric acid signaling pathway (GO:0007214)4.15458780
23neuron-neuron synaptic transmission (GO:0007270)4.12171417
24locomotory exploration behavior (GO:0035641)4.08195171
25neurotransmitter secretion (GO:0007269)4.02965231
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.00997381
27cerebellar Purkinje cell differentiation (GO:0021702)3.90989571
28response to histamine (GO:0034776)3.90792967
29regulation of synaptic vesicle transport (GO:1902803)3.87103887
30DNA deamination (GO:0045006)3.79954646
31exploration behavior (GO:0035640)3.77448432
32branching involved in labyrinthine layer morphogenesis (GO:0060670)3.76478799
33membrane hyperpolarization (GO:0060081)3.75062278
34postsynaptic membrane organization (GO:0001941)3.74259708
35cellular potassium ion homeostasis (GO:0030007)3.73939506
36sulfation (GO:0051923)3.71396378
37transmission of nerve impulse (GO:0019226)3.71312898
38layer formation in cerebral cortex (GO:0021819)3.70737295
39dendritic spine morphogenesis (GO:0060997)3.69199603
40presynaptic membrane assembly (GO:0097105)3.67212012
41regulation of postsynaptic membrane potential (GO:0060078)3.65004487
42neurotransmitter transport (GO:0006836)3.62878956
43mating behavior (GO:0007617)3.62757206
44water-soluble vitamin biosynthetic process (GO:0042364)3.61389984
45axonal fasciculation (GO:0007413)3.60249390
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59931786
47innervation (GO:0060384)3.59659099
48neurotransmitter-gated ion channel clustering (GO:0072578)3.59009952
49response to pheromone (GO:0019236)3.58607753
50regulation of neuronal synaptic plasticity (GO:0048168)3.56955852
51regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.56464041
52somite development (GO:0061053)3.55768590
53NADH dehydrogenase complex assembly (GO:0010257)3.55676783
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55676783
55mitochondrial respiratory chain complex I assembly (GO:0032981)3.55676783
56neuromuscular process controlling posture (GO:0050884)3.54185810
57negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.51804808
58proline transport (GO:0015824)3.51740193
59regulation of long-term neuronal synaptic plasticity (GO:0048169)3.51667555
60positive regulation of synaptic transmission, GABAergic (GO:0032230)3.49887367
61startle response (GO:0001964)3.48103991
62synaptic vesicle docking involved in exocytosis (GO:0016081)3.48048622
63long-term memory (GO:0007616)3.47201467
64positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.43587916
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.40804002
66positive regulation of synapse assembly (GO:0051965)3.38751035
67righting reflex (GO:0060013)3.35339792
68synapse assembly (GO:0007416)3.34582405
69positive regulation of membrane potential (GO:0045838)3.33850866
70response to auditory stimulus (GO:0010996)3.32938010
71protein complex biogenesis (GO:0070271)3.31212801
72synaptic vesicle endocytosis (GO:0048488)3.31173929
73presynaptic membrane organization (GO:0097090)3.31060823
74prostate gland growth (GO:0060736)3.28634182
75regulation of neurotransmitter levels (GO:0001505)3.28384212
76membrane depolarization (GO:0051899)3.26921629
77auditory behavior (GO:0031223)3.25350926
78serotonin metabolic process (GO:0042428)3.23520449
79regulation of glomerulus development (GO:0090192)3.21212674
80regulation of synapse structural plasticity (GO:0051823)3.18995893
81negative regulation of microtubule polymerization (GO:0031115)3.16884683
82regulation of action potential (GO:0098900)3.16789465
83gamma-aminobutyric acid transport (GO:0015812)3.15357313
84membrane depolarization during action potential (GO:0086010)3.14276577
85positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.14172300
86regulation of vesicle fusion (GO:0031338)3.13976486
873-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.13654940
88purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.13654940
89cerebellar granule cell differentiation (GO:0021707)3.11786831
90positive regulation of oligodendrocyte differentiation (GO:0048714)3.11288805
91primary amino compound metabolic process (GO:1901160)3.10079064
92membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.09653396
93regulation of respiratory system process (GO:0044065)3.08360768
94prepulse inhibition (GO:0060134)3.07878274
95positive regulation of synapse maturation (GO:0090129)3.07682826
96protein polyglutamylation (GO:0018095)3.07531353
97negative regulation of mast cell activation (GO:0033004)3.07129020
98regulation of neurotransmitter secretion (GO:0046928)3.06519204
99ovulation cycle (GO:0042698)3.05576801
100negative regulation of astrocyte differentiation (GO:0048712)3.04975727
101regulation of cell proliferation involved in kidney development (GO:1901722)3.02243484
102positive regulation of fatty acid oxidation (GO:0046321)3.01623623
103dendrite morphogenesis (GO:0048813)2.98619228
104negative regulation of synaptic transmission, GABAergic (GO:0032229)2.98523134
105cell differentiation in hindbrain (GO:0021533)2.98433962
106synaptic transmission (GO:0007268)2.98336074
107synapse organization (GO:0050808)2.97317431
108long-term synaptic potentiation (GO:0060291)2.96861496
109peristalsis (GO:0030432)2.96301395
110positive regulation of glomerulus development (GO:0090193)2.96170785
111regulation of mesoderm development (GO:2000380)2.95877015
112mitochondrial respiratory chain complex assembly (GO:0033108)2.93648914
113regulation of dopamine metabolic process (GO:0042053)2.93083553
114regulation of catecholamine metabolic process (GO:0042069)2.93083553
115spinal cord development (GO:0021510)2.92513869
116positive regulation of cardiac muscle cell differentiation (GO:2000727)2.91771763
117intraspecies interaction between organisms (GO:0051703)2.88533330
118social behavior (GO:0035176)2.88533330
119neuronal action potential (GO:0019228)2.87921081
120learning (GO:0007612)2.87141066
121mechanosensory behavior (GO:0007638)2.87128780
122regulation of synaptic plasticity (GO:0048167)2.86671547
123regulation of synapse assembly (GO:0051963)2.85516355
124negative regulation of systemic arterial blood pressure (GO:0003085)2.85251989
125regulation of respiratory gaseous exchange (GO:0043576)2.84808009
126positive regulation of dendritic spine development (GO:0060999)2.84600443
127regulation of neurotransmitter uptake (GO:0051580)2.83856601
128negative regulation of Rho protein signal transduction (GO:0035024)2.82128408
129regulation of neurotransmitter transport (GO:0051588)2.82076644
130otic vesicle formation (GO:0030916)2.81983895
131cell migration in hindbrain (GO:0021535)2.81554053
132positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.81540528
133regulation of glutamate secretion (GO:0014048)2.80097035
134negative regulation of dendrite morphogenesis (GO:0050774)2.79972176
135cochlea development (GO:0090102)2.79933077
136dendrite development (GO:0016358)2.79850002
137regulation of protein kinase A signaling (GO:0010738)2.79539160
138positive regulation of potassium ion transmembrane transport (GO:1901381)2.79471818
139negative regulation of response to food (GO:0032096)2.77838794
140negative regulation of appetite (GO:0032099)2.77838794
141dentate gyrus development (GO:0021542)2.77314498
142spindle assembly involved in mitosis (GO:0090307)2.77271432
143preassembly of GPI anchor in ER membrane (GO:0016254)2.77194367
144regulation of sequestering of triglyceride (GO:0010889)2.75529615
145cellular response to ATP (GO:0071318)2.75455762
146parturition (GO:0007567)2.71720392
147detection of light stimulus involved in sensory perception (GO:0050962)2.71349448
148detection of light stimulus involved in visual perception (GO:0050908)2.71349448
149magnesium ion transport (GO:0015693)2.69588207
150lateral sprouting from an epithelium (GO:0060601)2.67696912
151regulation of female receptivity (GO:0045924)2.67450449
152pharyngeal system development (GO:0060037)2.66924529
153kidney morphogenesis (GO:0060993)2.65051838
154lung-associated mesenchyme development (GO:0060484)2.64927799
155positive regulation of meiosis (GO:0045836)2.63499103
156establishment of protein localization to mitochondrial membrane (GO:0090151)2.61600680
157action potential (GO:0001508)2.57632856
158membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.56272874
159mitochondrion morphogenesis (GO:0070584)2.56023153
160artery development (GO:0060840)2.55519477
161lymphangiogenesis (GO:0001946)2.55116314
162indole-containing compound metabolic process (GO:0042430)2.52519890
163regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.51556163
164regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.51556163
165positive regulation of mitochondrial fission (GO:0090141)2.51102333
166endoderm formation (GO:0001706)2.50993898
167negative regulation of cytosolic calcium ion concentration (GO:0051481)2.49918633
168membrane repolarization during action potential (GO:0086011)2.48982884
169platelet dense granule organization (GO:0060155)2.45929628
170pituitary gland development (GO:0021983)2.45492674
171appendage development (GO:0048736)2.45326097
172limb development (GO:0060173)2.45326097
173regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.44585173
174indolalkylamine metabolic process (GO:0006586)2.44150390
175epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.42647085
176positive regulation of meiotic cell cycle (GO:0051446)2.42456384
177response to lipoprotein particle (GO:0055094)2.42022053
178cornea development in camera-type eye (GO:0061303)2.41877157
179regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.41719696
180retinal ganglion cell axon guidance (GO:0031290)2.40583323
181multicellular organismal signaling (GO:0035637)2.39698056
182epithelial cilium movement (GO:0003351)2.36098315
183calcium ion-dependent exocytosis (GO:0017156)2.35331785

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.78842808
2* GBX2_23144817_ChIP-Seq_PC3_Human3.96830676
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08570161
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07995277
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04819495
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.76944700
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.67943703
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.65982739
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65268900
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65268900
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.64711451
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63627029
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62858297
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54871681
15TAF15_26573619_Chip-Seq_HEK293_Human2.54318514
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.52145491
17REST_21632747_ChIP-Seq_MESCs_Mouse2.48678110
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44562530
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34631085
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31547673
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24563692
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21845883
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16994633
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.15688174
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.14472536
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13654887
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13099200
28STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07789590
29DROSHA_22980978_ChIP-Seq_HELA_Human2.04332849
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02945426
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.96697484
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89384768
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.80315284
34SMAD4_21799915_ChIP-Seq_A2780_Human1.77549370
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74351440
36* P300_19829295_ChIP-Seq_ESCs_Human1.73399350
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73124721
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.71352488
39AR_21572438_ChIP-Seq_LNCaP_Human1.69054793
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64249526
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63322625
42ZNF274_21170338_ChIP-Seq_K562_Hela1.61278878
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60302472
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59661087
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59083273
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57193441
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52438976
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.49398759
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47368441
50IGF1R_20145208_ChIP-Seq_DFB_Human1.46534252
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46008408
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.43480294
53RNF2_27304074_Chip-Seq_NSC_Mouse1.43099979
54* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43098860
55VDR_22108803_ChIP-Seq_LS180_Human1.41249492
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37862593
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37783385
58FUS_26573619_Chip-Seq_HEK293_Human1.37116093
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.35920870
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34261101
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33734263
62* AR_25329375_ChIP-Seq_VCAP_Human1.33553734
63IRF1_19129219_ChIP-ChIP_H3396_Human1.33310908
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.32756649
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30582211
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30252291
67* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28740526
68* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28376840
69* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27168786
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.27067058
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27027019
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.24067558
73* STAT3_23295773_ChIP-Seq_U87_Human1.22739074
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22474321
75* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21044362
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17908667
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17122964
78* TP53_20018659_ChIP-ChIP_R1E_Mouse1.16953706
79MYC_18940864_ChIP-ChIP_HL60_Human1.15813345
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13670620
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13360248
82* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12835998
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12214296
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11500763
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11157659
86* RUNX2_22187159_ChIP-Seq_PCA_Human1.10437931
87* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10347447
88* AR_19668381_ChIP-Seq_PC3_Human1.09889968
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09220346
90* TCF4_23295773_ChIP-Seq_U87_Human1.09010316
91* NANOG_18555785_Chip-Seq_ESCs_Mouse1.08825220
92* BCAT_22108803_ChIP-Seq_LS180_Human1.08760786
93* ER_23166858_ChIP-Seq_MCF-7_Human1.08727316
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.08423775
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08266939
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07359078
97* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06477847
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05598889
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05598889
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05220732
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03413008
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.03167179
103PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02984321
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02648389
105CBP_20019798_ChIP-Seq_JUKART_Human1.02648389
106TP53_18474530_ChIP-ChIP_U2OS_Human1.02575787
107P53_22387025_ChIP-Seq_ESCs_Mouse1.02382722
108ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02362717
109POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01294291
110YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00672057
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00592339
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.00483246
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.00101300
114TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99900968
115* JUN_21703547_ChIP-Seq_K562_Human0.99611408
116TAL1_26923725_Chip-Seq_HPCs_Mouse0.98533683
117AHR_22903824_ChIP-Seq_MCF-7_Human0.98360030
118* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98044250
119EWS_26573619_Chip-Seq_HEK293_Human0.92526497
120KDM2B_26808549_Chip-Seq_REH_Human0.92052439
121TP53_16413492_ChIP-PET_HCT116_Human0.90157063
122WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90119440
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.88953786
124* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88555319
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86699686
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86567081
127E2F1_18555785_Chip-Seq_ESCs_Mouse0.85911360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.88456359
2MP0004859_abnormal_synaptic_plasticity4.64505198
3MP0003635_abnormal_synaptic_transmissio3.75619930
4MP0009046_muscle_twitch3.15711085
5MP0009745_abnormal_behavioral_response3.13828708
6MP0005423_abnormal_somatic_nervous3.11447380
7MP0001968_abnormal_touch/_nociception3.06288516
8MP0004270_analgesia3.04536034
9MP0002064_seizures2.99907183
10MP0006276_abnormal_autonomic_nervous2.99617409
11MP0002063_abnormal_learning/memory/cond2.89290934
12MP0006292_abnormal_olfactory_placode2.77163632
13MP0002572_abnormal_emotion/affect_behav2.68075804
14MP0002272_abnormal_nervous_system2.63633847
15MP0001486_abnormal_startle_reflex2.60104697
16MP0002735_abnormal_chemical_nociception2.57628833
17MP0002734_abnormal_mechanical_nocicepti2.54147737
18MP0002160_abnormal_reproductive_system2.42152554
19MP0001501_abnormal_sleep_pattern2.33341069
20MP0002736_abnormal_nociception_after2.32162025
21MP0003646_muscle_fatigue2.26547505
22MP0002067_abnormal_sensory_capabilities2.23341445
23MP0000049_abnormal_middle_ear2.18717370
24MP0001440_abnormal_grooming_behavior2.18677359
25MP0002733_abnormal_thermal_nociception2.13045455
26MP0008877_abnormal_DNA_methylation2.12825124
27MP0002653_abnormal_ependyma_morphology2.08172676
28MP0002184_abnormal_innervation2.05677995
29MP0001529_abnormal_vocalization2.05214295
30MP0003122_maternal_imprinting2.04246714
31MP0001970_abnormal_pain_threshold1.99550103
32MP0002822_catalepsy1.97811819
33MP0009053_abnormal_anal_canal1.94393405
34MP0001984_abnormal_olfaction1.93457865
35MP0001905_abnormal_dopamine_level1.89295826
36MP0000778_abnormal_nervous_system1.87699543
37MP0005386_behavior/neurological_phenoty1.87599125
38MP0004924_abnormal_behavior1.87599125
39MP0003283_abnormal_digestive_organ1.83759435
40MP0005389_reproductive_system_phenotype1.79408211
41MP0005551_abnormal_eye_electrophysiolog1.78976150
42MP0002557_abnormal_social/conspecific_i1.78117093
43MP0000569_abnormal_digit_pigmentation1.77382101
44MP0005670_abnormal_white_adipose1.76024189
45MP0003011_delayed_dark_adaptation1.65458284
46MP0003119_abnormal_digestive_system1.62943032
47MP0004142_abnormal_muscle_tone1.58231454
48MP0001188_hyperpigmentation1.57563229
49MP0004130_abnormal_muscle_cell1.53911847
50MP0002909_abnormal_adrenal_gland1.53257033
51MP0003937_abnormal_limbs/digits/tail_de1.52489755
52MP0008569_lethality_at_weaning1.49889539
53MP0010386_abnormal_urinary_bladder1.47515667
54MP0000013_abnormal_adipose_tissue1.47347166
55MP0000955_abnormal_spinal_cord1.44851295
56MP0002882_abnormal_neuron_morphology1.44316304
57MP0009250_abnormal_appendicular_skeleto1.42164228
58MP0001502_abnormal_circadian_rhythm1.39746354
59MP0004811_abnormal_neuron_physiology1.39396214
60MP0005646_abnormal_pituitary_gland1.38478977
61MP0002066_abnormal_motor_capabilities/c1.35107577
62MP0003329_amyloid_beta_deposits1.33404088
63MP0004858_abnormal_nervous_system1.32317118
64MP0004133_heterotaxia1.30470660
65MP0005645_abnormal_hypothalamus_physiol1.29741859
66MP0003315_abnormal_perineum_morphology1.29361063
67MP0006072_abnormal_retinal_apoptosis1.27812596
68MP0000516_abnormal_urinary_system1.26445815
69MP0005367_renal/urinary_system_phenotyp1.26445815
70MP0000751_myopathy1.25951493
71MP0003787_abnormal_imprinting1.24022379
72MP0003938_abnormal_ear_development1.23461762
73MP0003879_abnormal_hair_cell1.21067770
74MP0002638_abnormal_pupillary_reflex1.17460113
75MP0004742_abnormal_vestibular_system1.16578620
76MP0002229_neurodegeneration1.15514492
77MP0009780_abnormal_chondrocyte_physiolo1.14866971
78MP0008789_abnormal_olfactory_epithelium1.11912776
79MP0002163_abnormal_gland_morphology1.11839180
80MP0000537_abnormal_urethra_morphology1.11673130
81MP0005409_darkened_coat_color1.11571798
82MP0002938_white_spotting1.11163960
83MP0002138_abnormal_hepatobiliary_system1.08630457
84MP0009384_cardiac_valve_regurgitation1.06829278
85MP0002752_abnormal_somatic_nervous1.05874242
86MP0003633_abnormal_nervous_system1.05651653
87MP0002090_abnormal_vision1.05315775
88MP0005084_abnormal_gallbladder_morpholo1.04705586
89MP0002152_abnormal_brain_morphology1.03910127
90MP0005379_endocrine/exocrine_gland_phen1.03536020
91MP0002928_abnormal_bile_duct1.03422515
92MP0004145_abnormal_muscle_electrophysio1.03108575
93MP0003942_abnormal_urinary_system1.02108067
94MP0005253_abnormal_eye_physiology0.99491413
95MP0004885_abnormal_endolymph0.96846401
96MP0008872_abnormal_physiological_respon0.96162660
97MP0001963_abnormal_hearing_physiology0.95950888
98MP0001919_abnormal_reproductive_system0.94688093
99MP0005394_taste/olfaction_phenotype0.94451438
100MP0005499_abnormal_olfactory_system0.94451438
101MP0000631_abnormal_neuroendocrine_gland0.93262374
102MP0003631_nervous_system_phenotype0.92624325
103MP0002282_abnormal_trachea_morphology0.92165924
104MP0000372_irregular_coat_pigmentation0.91572416
105MP0003936_abnormal_reproductive_system0.87555243
106MP0002234_abnormal_pharynx_morphology0.86920385
107MP0003634_abnormal_glial_cell0.83660622
108MP0004085_abnormal_heartbeat0.83654870
109MP0002102_abnormal_ear_morphology0.83427762
110MP0002069_abnormal_eating/drinking_beha0.82772975
111MP0005535_abnormal_body_temperature0.82273149
112MP0003121_genomic_imprinting0.81206114
113MP0002837_dystrophic_cardiac_calcinosis0.80917447
114MP0001299_abnormal_eye_distance/0.80636132
115MP0003195_calcinosis0.79426389
116MP0003137_abnormal_impulse_conducting0.73283523
117MP0000026_abnormal_inner_ear0.72768542
118MP0009379_abnormal_foot_pigmentation0.70884651
119MP0008874_decreased_physiological_sensi0.70810070
120MP0001485_abnormal_pinna_reflex0.67114949
121MP0003690_abnormal_glial_cell0.65777397
122MP0003632_abnormal_nervous_system0.65277069
123MP0002876_abnormal_thyroid_physiology0.65118373
124MP0001943_abnormal_respiration0.65117678
125MP0004215_abnormal_myocardial_fiber0.63935413
126MP0005195_abnormal_posterior_eye0.62947055
127MP0002751_abnormal_autonomic_nervous0.62641031
128MP0005623_abnormal_meninges_morphology0.62336570
129MP0003861_abnormal_nervous_system0.59476036
130MP0000920_abnormal_myelination0.59257197
131MP0002082_postnatal_lethality0.54915473
132MP0010770_preweaning_lethality0.54915473
133MP0001177_atelectasis0.53864756
134MP0001664_abnormal_digestion0.52663842
135MP0010769_abnormal_survival0.52496020
136MP0000534_abnormal_ureter_morphology0.49992529
137MP0010768_mortality/aging0.49744118

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.72163756
2Focal seizures (HP:0007359)5.66945022
3Myokymia (HP:0002411)5.24380022
4Atonic seizures (HP:0010819)5.22519173
5Febrile seizures (HP:0002373)4.85779497
6Absence seizures (HP:0002121)4.75189145
7Short 1st metacarpal (HP:0010034)4.68131653
8Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.68131653
9Epileptic encephalopathy (HP:0200134)4.64707015
10Stenosis of the external auditory canal (HP:0000402)4.59745956
11Visual hallucinations (HP:0002367)4.41928023
12Dialeptic seizures (HP:0011146)4.35917027
13Progressive cerebellar ataxia (HP:0002073)4.33726391
14Abnormality of the 1st metacarpal (HP:0010009)4.10370332
15Generalized tonic-clonic seizures (HP:0002069)4.05360577
16Pendular nystagmus (HP:0012043)3.74954268
17Broad-based gait (HP:0002136)3.54902527
18Short hallux (HP:0010109)3.53467467
19Pancreatic cysts (HP:0001737)3.47617465
20Aplasia/Hypoplasia of the hallux (HP:0008362)3.37714226
21Supranuclear gaze palsy (HP:0000605)3.28509183
22Pancreatic fibrosis (HP:0100732)3.27241250
23Abnormality of the proximal phalanges of the hand (HP:0009834)3.22280491
24Hyperventilation (HP:0002883)3.17608896
25Congenital stationary night blindness (HP:0007642)3.12881725
26Symphalangism affecting the phalanges of the hand (HP:0009773)3.11878127
27Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.08293878
28Short phalanx of the thumb (HP:0009660)3.08085499
29Action tremor (HP:0002345)3.07649671
30Limb dystonia (HP:0002451)3.03724048
31Abnormality of the middle phalanges of the toes (HP:0010183)3.02021129
32Truncal ataxia (HP:0002078)3.01847722
33Increased corneal curvature (HP:0100692)3.01847304
34Keratoconus (HP:0000563)3.01847304
35True hermaphroditism (HP:0010459)2.99240982
36Ectopic kidney (HP:0000086)2.99131043
37Abnormality of midbrain morphology (HP:0002418)2.97435940
38Molar tooth sign on MRI (HP:0002419)2.97435940
39Absent thumb (HP:0009777)2.95812070
40Polyphagia (HP:0002591)2.95558214
41Excessive salivation (HP:0003781)2.93068860
42Drooling (HP:0002307)2.93068860
43Amblyopia (HP:0000646)2.91923369
44Abnormality of the phalanges of the 5th finger (HP:0004213)2.90172733
45Dysdiadochokinesis (HP:0002075)2.87350827
46Nephronophthisis (HP:0000090)2.86053500
47Abnormal eating behavior (HP:0100738)2.85841266
48Fused cervical vertebrae (HP:0002949)2.82552618
49Synostosis of carpal bones (HP:0005048)2.79100776
50Urinary bladder sphincter dysfunction (HP:0002839)2.79002089
51Abnormality of the renal collecting system (HP:0004742)2.78059561
52Gaze-evoked nystagmus (HP:0000640)2.72606343
53Morphological abnormality of the middle ear (HP:0008609)2.72007182
54Anxiety (HP:0000739)2.71616486
55Hemiparesis (HP:0001269)2.67850664
56Epileptiform EEG discharges (HP:0011182)2.67770631
57Neurofibrillary tangles (HP:0002185)2.64269630
58EEG with generalized epileptiform discharges (HP:0011198)2.63051524
59Dysmetria (HP:0001310)2.61580428
60Progressive inability to walk (HP:0002505)2.60043066
61Mutism (HP:0002300)2.57864011
62Abnormality of the nasal septum (HP:0000419)2.57620757
63Abolished electroretinogram (ERG) (HP:0000550)2.54324925
64Abnormality of DNA repair (HP:0003254)2.53657798
65Impaired vibration sensation in the lower limbs (HP:0002166)2.51438595
66Ankle clonus (HP:0011448)2.49158432
67Papilledema (HP:0001085)2.48465143
68Cerebral inclusion bodies (HP:0100314)2.47177459
69Agitation (HP:0000713)2.47106040
70Osteomalacia (HP:0002749)2.45664588
71Depression (HP:0000716)2.44524598
72Gait imbalance (HP:0002141)2.44109470
73Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.44099210
74Pheochromocytoma (HP:0002666)2.43821122
75Abnormality of the corticospinal tract (HP:0002492)2.43527957
76Chorioretinal atrophy (HP:0000533)2.41528297
77Termporal pattern (HP:0011008)2.38255132
78Insidious onset (HP:0003587)2.38255132
79Genetic anticipation (HP:0003743)2.37385570
80Carpal bone hypoplasia (HP:0001498)2.36540110
81Hypoventilation (HP:0002791)2.35271807
82Congenital sensorineural hearing impairment (HP:0008527)2.34894949
83Spastic gait (HP:0002064)2.34702539
84Protruding tongue (HP:0010808)2.33808827
85Humeroradial synostosis (HP:0003041)2.31145105
86Synostosis involving the elbow (HP:0003938)2.31145105
87Hypoplasia of the ulna (HP:0003022)2.30576040
88Abnormality of the renal medulla (HP:0100957)2.30301971
89Methylmalonic acidemia (HP:0002912)2.29872429
90Diplopia (HP:0000651)2.28733424
91Abnormality of binocular vision (HP:0011514)2.28733424
92Abnormality of macular pigmentation (HP:0008002)2.28171236
93Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.27796693
94Abnormality of the phalanges of the 2nd finger (HP:0009541)2.26307862
95Absent speech (HP:0001344)2.25045836
96Decreased subcutaneous fat (HP:0001002)2.23237895
97Poor eye contact (HP:0000817)2.22905112
98Esotropia (HP:0000565)2.21924260
99Hypsarrhythmia (HP:0002521)2.21360526
100Inability to walk (HP:0002540)2.18543101
101Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18004766
102Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16870356
103Decreased central vision (HP:0007663)2.16822637
104Scanning speech (HP:0002168)2.16606828
105Congenital, generalized hypertrichosis (HP:0004540)2.16214015
106Abnormal rod and cone electroretinograms (HP:0008323)2.14022912
107Neuroendocrine neoplasm (HP:0100634)2.10639471
108Cystic liver disease (HP:0006706)2.10162245
109Exotropia (HP:0000577)2.09155538
110Status epilepticus (HP:0002133)2.08365573
111Fetal akinesia sequence (HP:0001989)2.07506928
112Concave nail (HP:0001598)2.06581309
113Abnormality of salivation (HP:0100755)2.06265224
114Hypoplasia of the uterus (HP:0000013)2.05913085
115Absent/shortened dynein arms (HP:0200106)2.05401041
116Dynein arm defect of respiratory motile cilia (HP:0012255)2.05401041
117Acute necrotizing encephalopathy (HP:0006965)2.04479991
118Failure to thrive in infancy (HP:0001531)2.03664539
119Specific learning disability (HP:0001328)2.03155908
120Genital tract atresia (HP:0001827)2.02594035
121Urinary urgency (HP:0000012)2.01425461
122Impaired social interactions (HP:0000735)2.01065831
123Abnormal social behavior (HP:0012433)2.01065831
124Blue irides (HP:0000635)2.00896321
125Medial flaring of the eyebrow (HP:0010747)2.00720303
126Sclerocornea (HP:0000647)1.99670549
127Reticulocytopenia (HP:0001896)1.98624942
128Generalized myoclonic seizures (HP:0002123)1.98583002
129Congenital primary aphakia (HP:0007707)1.98475887
130Psychosis (HP:0000709)1.98026603
131Abnormality of the renal cortex (HP:0011035)1.97659493
132Vaginal atresia (HP:0000148)1.97261283
133Narrow nasal bridge (HP:0000446)1.96842868
134Degeneration of the lateral corticospinal tracts (HP:0002314)1.96615354
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96615354
136Impaired smooth pursuit (HP:0007772)1.95993966
137Mitochondrial inheritance (HP:0001427)1.95531269
138Aplasia/hypoplasia of the uterus (HP:0008684)1.94830805
139Abnormal ciliary motility (HP:0012262)1.93883740
140Lower limb muscle weakness (HP:0007340)1.91854862
141Chronic hepatic failure (HP:0100626)1.91773635
142Tachypnea (HP:0002789)1.91521168
143Bradykinesia (HP:0002067)1.90998762
144Hyperthyroidism (HP:0000836)1.90967068
145Acute encephalopathy (HP:0006846)1.89650968
146Abnormal number of erythroid precursors (HP:0012131)1.89478747
147Bony spicule pigmentary retinopathy (HP:0007737)1.88915692
148Progressive macrocephaly (HP:0004481)1.88831541
149Hypoplasia of the radius (HP:0002984)1.88778097
150Aplasia/Hypoplasia of the brainstem (HP:0007362)1.88332015
151Hypoplasia of the brainstem (HP:0002365)1.88332015
152Duplicated collecting system (HP:0000081)1.88117758
153Cutaneous finger syndactyly (HP:0010554)1.87914837
154Postural instability (HP:0002172)1.87394506
155Aplasia/Hypoplasia of the ulna (HP:0006495)1.86883823
156Oligomenorrhea (HP:0000876)1.85956049
157Hemiplegia (HP:0002301)1.85396164
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.83935822
159Abnormal hair whorl (HP:0010721)1.83679453
160Central scotoma (HP:0000603)1.83625470
161Aplasia/Hypoplasia involving the musculature (HP:0001460)1.83318867
162Methylmalonic aciduria (HP:0012120)1.83094413
163Nephrogenic diabetes insipidus (HP:0009806)1.82899706
164Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81224932
165Absent phalangeal crease (HP:0006109)1.80519443
166Prolonged QT interval (HP:0001657)1.80195385
167Abnormal mitochondria in muscle tissue (HP:0008316)1.80188937
168Severe visual impairment (HP:0001141)1.79972630
169Abnormality of cells of the erythroid lineage (HP:0012130)1.79582431
170Torticollis (HP:0000473)1.79267369
171Carpal synostosis (HP:0009702)1.78290990
172Furrowed tongue (HP:0000221)1.75853087
173Tubular atrophy (HP:0000092)1.75577025
174Maternal diabetes (HP:0009800)1.75313183
175Horseshoe kidney (HP:0000085)1.75132720
176Type II lissencephaly (HP:0007260)1.74290863
177Male pseudohermaphroditism (HP:0000037)1.73232836
178Abnormal respiratory motile cilium morphology (HP:0005938)1.72628478
179Abnormal respiratory epithelium morphology (HP:0012253)1.72628478
180Short tibia (HP:0005736)1.72246674
181Aplasia/Hypoplasia of the spleen (HP:0010451)1.71990310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.19518740
2NTRK34.01776581
3GRK13.92520499
4MARK13.67517802
5CASK3.45418957
6MAP3K93.20569811
7MAP3K43.10977902
8TNIK2.95654141
9MAP3K122.95399275
10TLK12.86998216
11EPHA42.84312147
12PNCK2.81196375
13MAP2K72.74252537
14MINK12.63004324
15NTRK22.58002067
16PINK12.27363305
17SIK22.04755171
18MAPK132.03631902
19MAP2K42.01142081
20NTRK11.72004109
21MAP4K21.65311739
22PAK61.62089071
23INSRR1.59958887
24NUAK11.51306161
25ZAK1.49970127
26FES1.48125339
27GRK51.47526880
28UHMK11.46863425
29PHKG21.45088146
30PHKG11.45088146
31CDK51.41516294
32PLK21.39233808
33RIPK41.39024052
34TAOK31.31105067
35GRK71.29486349
36NME11.27940436
37STK161.27363992
38DAPK21.18658708
39PRKD21.13584045
40PRKCG1.13521729
41CAMK2A1.13089233
42FGFR21.06561367
43KSR11.04404058
44LATS21.02594365
45STK381.02268879
46PRPF4B1.00225189
47TIE10.98168280
48LMTK20.97747644
49TXK0.96843918
50ACVR1B0.96645021
51CAMK2B0.96208047
52CDK190.93457261
53CSNK1G20.93376469
54SIK30.92991834
55BCKDK0.92600511
56DYRK1A0.91359964
57BCR0.89116208
58PAK30.88616340
59WNK30.88296267
60DAPK10.87996587
61PIK3CA0.85138004
62TNK20.83921027
63CSNK1G10.83880804
64FER0.83307736
65CDK180.82968584
66CDK90.82648671
67CDK140.81738811
68SGK4940.80804837
69SGK2230.80804837
70FGR0.80566309
71KSR20.80149348
72LIMK10.79411490
73CDK150.79086539
74OXSR10.78904091
75CAMK1G0.78770478
76ARAF0.76765521
77MAP2K10.75867183
78CSNK1A10.75818476
79ADRBK20.74550570
80ADRBK10.74362958
81CAMK2D0.73740022
82STK390.73563932
83CDC42BPA0.72320912
84CAMKK10.72209326
85CDK11A0.70426565
86WNK10.70151658
87PRKCE0.69803781
88AURKA0.69557347
89MARK20.68944649
90CAMK10.68676902
91MKNK20.67977445
92ROCK20.63935712
93SGK20.63712100
94CSNK1G30.63662107
95PKN10.60290973
96STK110.59993885
97SGK10.58411185
98PASK0.56646781
99MUSK0.56195980
100CDC70.56145290
101TEC0.55422843
102WNK40.54779150
103TYRO30.54418091
104VRK10.54074979
105PTK2B0.53992822
106TGFBR10.53440904
107FLT30.53238928
108PRKCZ0.52456248
109PRKCH0.51311140
110AKT30.51150311
111RPS6KA60.50359630
112MAPK100.50122148
113RPS6KA50.48235187
114CSNK1D0.48175496
115BMPR1B0.47382361
116RPS6KA30.47042156
117MAP3K130.46874840
118MAP3K60.46817038
119DYRK20.46489950
120PRKCB0.45997782
121PRKD30.45766638
122RET0.45212400
123PRKACA0.45199456
124CSNK1E0.44761014
125PRKCI0.44629106
126PRKCQ0.44037336
127MAPKAPK30.43495935
128RPS6KA20.43217381
129CAMK2G0.42623789
130MAP3K70.42540449
131MAPK120.42089947
132PRKG10.41316448
133DYRK30.40191150
134FYN0.38542086
135MAPK150.38288520
136CAMKK20.38114225
137PRKCA0.37600029
138BMPR20.36880555
139CSNK1A1L0.36436189
140ABL20.36260553
141PLK40.35213414
142PRKACG0.33126636
143ERBB20.33034094

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.90476654
2Synaptic vesicle cycle_Homo sapiens_hsa047213.35741253
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.01120048
4GABAergic synapse_Homo sapiens_hsa047272.94553930
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.90764635
6Glutamatergic synapse_Homo sapiens_hsa047242.58282021
7Morphine addiction_Homo sapiens_hsa050322.58225727
8Circadian entrainment_Homo sapiens_hsa047132.53733753
9Long-term potentiation_Homo sapiens_hsa047202.39269207
10Olfactory transduction_Homo sapiens_hsa047402.32960691
11Taste transduction_Homo sapiens_hsa047422.29652788
12Amphetamine addiction_Homo sapiens_hsa050312.26788243
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.11067641
14Dopaminergic synapse_Homo sapiens_hsa047282.10705201
15Salivary secretion_Homo sapiens_hsa049702.10609068
16Serotonergic synapse_Homo sapiens_hsa047262.03170950
17Insulin secretion_Homo sapiens_hsa049112.02776376
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99037238
19Oxidative phosphorylation_Homo sapiens_hsa001901.87343127
20Ribosome_Homo sapiens_hsa030101.82966657
21Collecting duct acid secretion_Homo sapiens_hsa049661.82712910
22Renin secretion_Homo sapiens_hsa049241.82346707
23Cholinergic synapse_Homo sapiens_hsa047251.79212620
24Long-term depression_Homo sapiens_hsa047301.78522837
25Phototransduction_Homo sapiens_hsa047441.76065010
26Cardiac muscle contraction_Homo sapiens_hsa042601.74175064
27Cocaine addiction_Homo sapiens_hsa050301.72558176
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69781734
29Gastric acid secretion_Homo sapiens_hsa049711.65313792
30Linoleic acid metabolism_Homo sapiens_hsa005911.63572525
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63497355
32Calcium signaling pathway_Homo sapiens_hsa040201.63382375
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61148440
34Sulfur metabolism_Homo sapiens_hsa009201.55616520
35Alzheimers disease_Homo sapiens_hsa050101.53715363
36Oxytocin signaling pathway_Homo sapiens_hsa049211.50583889
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49717463
38Parkinsons disease_Homo sapiens_hsa050121.49448285
39Nitrogen metabolism_Homo sapiens_hsa009101.49121053
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44921962
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40961199
42Gap junction_Homo sapiens_hsa045401.34601797
43GnRH signaling pathway_Homo sapiens_hsa049121.32013552
44Sulfur relay system_Homo sapiens_hsa041221.31743795
45Chemical carcinogenesis_Homo sapiens_hsa052041.26627278
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22848361
47Selenocompound metabolism_Homo sapiens_hsa004501.20594353
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19869975
49Protein export_Homo sapiens_hsa030601.15175646
50Vibrio cholerae infection_Homo sapiens_hsa051101.13767110
51RNA polymerase_Homo sapiens_hsa030201.12306064
52* Axon guidance_Homo sapiens_hsa043601.11982869
53Huntingtons disease_Homo sapiens_hsa050161.11231865
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.11126249
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09947428
56cAMP signaling pathway_Homo sapiens_hsa040241.09021031
57Retinol metabolism_Homo sapiens_hsa008301.07561603
58Estrogen signaling pathway_Homo sapiens_hsa049151.07189476
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05853162
60Butanoate metabolism_Homo sapiens_hsa006501.04042377
61Basal cell carcinoma_Homo sapiens_hsa052171.01755177
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01348719
63Tryptophan metabolism_Homo sapiens_hsa003801.01324895
64Melanogenesis_Homo sapiens_hsa049161.00477358
65RNA degradation_Homo sapiens_hsa030181.00004707
66Caffeine metabolism_Homo sapiens_hsa002320.97945428
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.96546190
68Basal transcription factors_Homo sapiens_hsa030220.95994990
69Homologous recombination_Homo sapiens_hsa034400.94323693
70Fanconi anemia pathway_Homo sapiens_hsa034600.92434818
71Renin-angiotensin system_Homo sapiens_hsa046140.90388853
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89228691
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88944634
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85561139
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84914468
76Type II diabetes mellitus_Homo sapiens_hsa049300.84161682
77Pancreatic secretion_Homo sapiens_hsa049720.83363089
78Glycerolipid metabolism_Homo sapiens_hsa005610.82794726
79Dilated cardiomyopathy_Homo sapiens_hsa054140.79228884
80ErbB signaling pathway_Homo sapiens_hsa040120.77387238
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77138738
82* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73756438
83Circadian rhythm_Homo sapiens_hsa047100.70932871
84Thyroid hormone synthesis_Homo sapiens_hsa049180.66250277
85Glioma_Homo sapiens_hsa052140.65908998
86Oocyte meiosis_Homo sapiens_hsa041140.65494002
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.65115678
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64575485
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63767895
90African trypanosomiasis_Homo sapiens_hsa051430.62893700
91Regulation of autophagy_Homo sapiens_hsa041400.62663412
92MAPK signaling pathway_Homo sapiens_hsa040100.60116570
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58722658
94Dorso-ventral axis formation_Homo sapiens_hsa043200.58710159
95Fat digestion and absorption_Homo sapiens_hsa049750.58687726
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57949768
97Melanoma_Homo sapiens_hsa052180.57616786
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55880513
99Hippo signaling pathway_Homo sapiens_hsa043900.54466048
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54401604
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.54352873
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54335928
103Wnt signaling pathway_Homo sapiens_hsa043100.54110957
104Alcoholism_Homo sapiens_hsa050340.52400629
105One carbon pool by folate_Homo sapiens_hsa006700.51982942
106Choline metabolism in cancer_Homo sapiens_hsa052310.49940436
107TGF-beta signaling pathway_Homo sapiens_hsa043500.49504422
108Arachidonic acid metabolism_Homo sapiens_hsa005900.49172361
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48803836
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48004214
111Glucagon signaling pathway_Homo sapiens_hsa049220.47874888
112Hedgehog signaling pathway_Homo sapiens_hsa043400.47574547
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47441521
114Peroxisome_Homo sapiens_hsa041460.46920585
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45426966
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44946127
117Inositol phosphate metabolism_Homo sapiens_hsa005620.44576456
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.43722983
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42533622
120Ras signaling pathway_Homo sapiens_hsa040140.41786507
121Ovarian steroidogenesis_Homo sapiens_hsa049130.38303229
122Rap1 signaling pathway_Homo sapiens_hsa040150.36317617
123Mineral absorption_Homo sapiens_hsa049780.36286477
124Rheumatoid arthritis_Homo sapiens_hsa053230.36250125
125Metabolic pathways_Homo sapiens_hsa011000.36197153
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35457082
127Purine metabolism_Homo sapiens_hsa002300.34777584
128Bile secretion_Homo sapiens_hsa049760.32712905
129Prion diseases_Homo sapiens_hsa050200.30227282
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30011056
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29691472
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27889088
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.27125157
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26510237
135Phagosome_Homo sapiens_hsa041450.25821673
136Ether lipid metabolism_Homo sapiens_hsa005650.22964710
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22765645
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.21137081
139Type I diabetes mellitus_Homo sapiens_hsa049400.20799333
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20039587
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.19120811
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18292970
143Renal cell carcinoma_Homo sapiens_hsa052110.18280074
144Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17933749
145VEGF signaling pathway_Homo sapiens_hsa043700.17463585

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