NTPCR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a non-specific nucleoside triphosphatase that is slow-acting in vitro. This gene is overexpressed in many tumor tissues, and while it is not essential for the cell, overexpression is cytotoxic. However, the cytotoxicity is not related to its triphosphatase activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.23189908
2DNA deamination (GO:0045006)5.63579555
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.50525420
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.14092976
5viral transcription (GO:0019083)4.99825128
6ATP synthesis coupled proton transport (GO:0015986)4.86385844
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.86385844
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.80864204
9regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.78515331
10translational termination (GO:0006415)4.73917613
11ribosomal small subunit biogenesis (GO:0042274)4.57587585
12respiratory electron transport chain (GO:0022904)4.46042640
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.44739126
14translational elongation (GO:0006414)4.38638141
15electron transport chain (GO:0022900)4.38214248
16cotranslational protein targeting to membrane (GO:0006613)4.36834709
17protein targeting to ER (GO:0045047)4.32400917
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.31321554
19chaperone-mediated protein transport (GO:0072321)4.22362295
20protein localization to endoplasmic reticulum (GO:0070972)4.17670490
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.16159059
22NADH dehydrogenase complex assembly (GO:0010257)4.16159059
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.16159059
24establishment of protein localization to endoplasmic reticulum (GO:0072599)4.07753595
25regulation of mitochondrial translation (GO:0070129)3.96511381
26positive regulation of chemokine secretion (GO:0090197)3.85792444
27viral life cycle (GO:0019058)3.76895450
28maturation of SSU-rRNA (GO:0030490)3.75652656
29neutrophil activation involved in immune response (GO:0002283)3.64020378
30response to interferon-beta (GO:0035456)3.62673078
31cellular protein complex disassembly (GO:0043624)3.62541074
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.53586865
33immunoglobulin mediated immune response (GO:0016064)3.51155087
34microglial cell activation (GO:0001774)3.50291439
35rRNA modification (GO:0000154)3.47421137
36water-soluble vitamin biosynthetic process (GO:0042364)3.44881785
37regulation of B cell receptor signaling pathway (GO:0050855)3.43134918
38translational initiation (GO:0006413)3.42866205
39ribosomal large subunit biogenesis (GO:0042273)3.41184211
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.39688566
41termination of RNA polymerase III transcription (GO:0006386)3.39688566
42G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.37897792
43sequestering of actin monomers (GO:0042989)3.33082517
44respiratory chain complex IV assembly (GO:0008535)3.31632409
45telomere maintenance via semi-conservative replication (GO:0032201)3.31616596
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.30135187
47DNA damage response, detection of DNA damage (GO:0042769)3.29982388
48platelet dense granule organization (GO:0060155)3.28659355
49positive regulation of B cell differentiation (GO:0045579)3.27255647
50translation (GO:0006412)3.14366587
51antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.12705275
52mast cell activation (GO:0045576)3.12677336
53peptidyl-histidine modification (GO:0018202)3.11377907
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.09682197
55DNA strand elongation involved in DNA replication (GO:0006271)3.08035779
56protein complex disassembly (GO:0043241)3.04476760
57cytochrome complex assembly (GO:0017004)3.02327004
58DNA strand elongation (GO:0022616)3.00638191
59B cell mediated immunity (GO:0019724)2.98357166
60protein neddylation (GO:0045116)2.97227619
61positive regulation of prostaglandin secretion (GO:0032308)2.96898431
62establishment of integrated proviral latency (GO:0075713)2.96871416
63positive regulation of antigen processing and presentation (GO:0002579)2.96864098
64establishment of protein localization to mitochondrion (GO:0072655)2.96565525
65cullin deneddylation (GO:0010388)2.95183304
66lactate metabolic process (GO:0006089)2.94253718
67macromolecular complex disassembly (GO:0032984)2.93991136
68establishment of viral latency (GO:0019043)2.92236954
69chromatin remodeling at centromere (GO:0031055)2.92174371
70regulation of hexokinase activity (GO:1903299)2.92123122
71regulation of glucokinase activity (GO:0033131)2.92123122
72ATP biosynthetic process (GO:0006754)2.91078881
73hydrogen ion transmembrane transport (GO:1902600)2.89181005
74metallo-sulfur cluster assembly (GO:0031163)2.88832790
75iron-sulfur cluster assembly (GO:0016226)2.88832790
76protein localization to mitochondrion (GO:0070585)2.87212255
77protein targeting to membrane (GO:0006612)2.85544868
78respiratory burst (GO:0045730)2.84800327
79telomere maintenance via recombination (GO:0000722)2.82582921
80regulation of chemokine secretion (GO:0090196)2.82238082
81rRNA methylation (GO:0031167)2.81864728
82CENP-A containing nucleosome assembly (GO:0034080)2.81856797
83myeloid cell activation involved in immune response (GO:0002275)2.78607563
84purine nucleoside triphosphate biosynthetic process (GO:0009145)2.77586771
85inner mitochondrial membrane organization (GO:0007007)2.77075639
86pseudouridine synthesis (GO:0001522)2.75999432
87purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.74921996
88positive regulation of gamma-delta T cell activation (GO:0046645)2.74170285
89nuclear-transcribed mRNA catabolic process (GO:0000956)2.74104489
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71616802
91mature B cell differentiation involved in immune response (GO:0002313)2.70817471
92antigen processing and presentation via MHC class Ib (GO:0002475)2.70809326
93purinergic nucleotide receptor signaling pathway (GO:0035590)2.69645079
94regulation of B cell differentiation (GO:0045577)2.68309092
95replication fork processing (GO:0031297)2.68212688
96proton transport (GO:0015992)2.66327534
97GTP biosynthetic process (GO:0006183)2.65233398
98intracellular protein transmembrane import (GO:0044743)2.65174479
99cellular response to interferon-beta (GO:0035458)2.63908579
100mRNA catabolic process (GO:0006402)2.63421688
101regulation of prostaglandin secretion (GO:0032306)2.62130569
102response to interferon-alpha (GO:0035455)2.61960482
103regulation of interferon-beta biosynthetic process (GO:0045357)2.61751430
104Arp2/3 complex-mediated actin nucleation (GO:0034314)2.61295585
105ribonucleoprotein complex biogenesis (GO:0022613)2.60760173
106myeloid dendritic cell activation (GO:0001773)2.60684628
107hydrogen transport (GO:0006818)2.60510044
108deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.59883243
109negative regulation of granulocyte differentiation (GO:0030853)2.59855652
110modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.59834924
111positive regulation by organism of defense response of other organism involved in symbiotic interact2.59834924
112modulation by symbiont of host immune response (GO:0052553)2.59834924
113positive regulation by symbiont of host defense response (GO:0052509)2.59834924
114modulation by symbiont of host defense response (GO:0052031)2.59834924
115modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.59834924
116ribonucleoside triphosphate biosynthetic process (GO:0009201)2.59264070
117mitochondrial transport (GO:0006839)2.59205007
118cellular component biogenesis (GO:0044085)2.59128812
119mast cell activation involved in immune response (GO:0002279)2.58761869
120mast cell degranulation (GO:0043303)2.58761869
121macrophage differentiation (GO:0030225)2.57930598
122protein complex biogenesis (GO:0070271)2.57790607
123protein-cofactor linkage (GO:0018065)2.57659925
124resolution of meiotic recombination intermediates (GO:0000712)2.57588458
125regulation of antigen processing and presentation (GO:0002577)2.57493220
126proteasome assembly (GO:0043248)2.57265743
127macrophage activation involved in immune response (GO:0002281)2.55949939
128exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.55322445
129regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.54310504
130oxidative phosphorylation (GO:0006119)2.53824830
131aldehyde catabolic process (GO:0046185)2.53451385
132signal peptide processing (GO:0006465)2.53273968
133L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.52486548
134nucleobase biosynthetic process (GO:0046112)2.52016076
135mitochondrial respiratory chain complex assembly (GO:0033108)2.50123455
136spliceosomal snRNP assembly (GO:0000387)2.49720696
137protein deneddylation (GO:0000338)2.49577250
138negative regulation of phagocytosis (GO:0050765)2.48078154
139positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.47907373
140phagocytosis, engulfment (GO:0006911)2.47771038
141tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.47732020
142RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.47732020
143protein targeting to mitochondrion (GO:0006626)2.46905984
144histone exchange (GO:0043486)2.46237615
145nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.45984572
146macrophage activation (GO:0042116)2.45955383
147regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.45397323
148regulation of mitotic spindle checkpoint (GO:1903504)2.45397323
149RNA catabolic process (GO:0006401)2.45215336
150DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.45100322
151negative regulation of erythrocyte differentiation (GO:0045647)2.44844731
152rRNA processing (GO:0006364)2.44697166
153DNA double-strand break processing (GO:0000729)2.44128025
154negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.44127404
155negative regulation of ligase activity (GO:0051352)2.44127404
156aerobic respiration (GO:0009060)2.43833123
157purine nucleobase biosynthetic process (GO:0009113)2.42727230
158DNA replication checkpoint (GO:0000076)2.42377400
159regulation of helicase activity (GO:0051095)2.40350226
160protein K6-linked ubiquitination (GO:0085020)2.39620230
161kinetochore assembly (GO:0051382)2.39201587
162nucleoside triphosphate biosynthetic process (GO:0009142)2.38501020
163regulation of cellular amino acid metabolic process (GO:0006521)2.38058944
164purine nucleoside monophosphate biosynthetic process (GO:0009127)2.36776492
165purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.36776492
166branched-chain amino acid catabolic process (GO:0009083)2.36219720
167tRNA processing (GO:0008033)2.34332561
168signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.32487647
169signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.32487647
170signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.32487647
171anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.31459266

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.85897703
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51036414
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.35904871
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.33526740
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.29569702
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.17650807
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.16979049
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.11783815
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03126967
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00652507
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.94059144
12E2F7_22180533_ChIP-Seq_HELA_Human2.90066747
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.88433732
14FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.81395062
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81320619
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76401274
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.60655116
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.60605260
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.56395120
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.53140585
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.49001857
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43811752
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41019007
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.38045632
25SPI1_23547873_ChIP-Seq_NB4_Human2.37333616
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32914970
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.28382368
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.20477511
29IRF8_27001747_Chip-Seq_BMDM_Mouse2.16174501
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.08747596
31SCL_19346495_ChIP-Seq_HPC-7_Human2.07900407
32VDR_22108803_ChIP-Seq_LS180_Human2.05567689
33SRF_21415370_ChIP-Seq_HL-1_Mouse2.04833777
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03079938
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02353879
36VDR_23849224_ChIP-Seq_CD4+_Human2.01056478
37ERG_20887958_ChIP-Seq_HPC-7_Mouse2.00933951
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.98611993
39MYC_18940864_ChIP-ChIP_HL60_Human1.93440481
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91134879
41FOXP3_21729870_ChIP-Seq_TREG_Human1.90552930
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.89345296
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87289803
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86595571
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84242068
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83705481
47IGF1R_20145208_ChIP-Seq_DFB_Human1.80694792
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.80398103
49EWS_26573619_Chip-Seq_HEK293_Human1.79341201
50ZNF274_21170338_ChIP-Seq_K562_Hela1.78578872
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77217886
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75488521
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.75328475
54FUS_26573619_Chip-Seq_HEK293_Human1.74533806
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74341196
56XRN2_22483619_ChIP-Seq_HELA_Human1.73699241
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72904514
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69085442
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66832334
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66507265
61VDR_21846776_ChIP-Seq_THP-1_Human1.66252830
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65968168
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60542287
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59466451
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57870921
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.57401696
67DCP1A_22483619_ChIP-Seq_HELA_Human1.56657001
68VDR_24763502_ChIP-Seq_THP-1_Human1.52062622
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51789358
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49647771
71GABP_19822575_ChIP-Seq_HepG2_Human1.44844158
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43911561
73MYB_26560356_Chip-Seq_TH2_Human1.43444043
74TTF2_22483619_ChIP-Seq_HELA_Human1.41856942
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40798550
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38473063
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.38282352
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37717980
79FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36909963
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.36790648
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35278823
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33358234
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33279276
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33201174
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33185745
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29506654
87NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28090460
88THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27162636
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26613887
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.26418884
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25840509
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24731063
93CBX2_27304074_Chip-Seq_ESCs_Mouse1.23942268
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23865855
95P300_19829295_ChIP-Seq_ESCs_Human1.23768657
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23745415
97SOX2_16153702_ChIP-ChIP_HESCs_Human1.23681233
98E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22084555
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20294998
100FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.20254820
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19945256
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18880065
103ELK1_19687146_ChIP-ChIP_HELA_Human1.17722875
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16525613
105IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16522515
106BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16009392
107PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15251828
108ELK1_22589737_ChIP-Seq_MCF10A_Human1.14018014
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13762162
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12007774
111FLI1_27457419_Chip-Seq_LIVER_Mouse1.11496808
112GBX2_23144817_ChIP-Seq_PC3_Human1.11034311
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09913113
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09561004
115NANOG_16153702_ChIP-ChIP_HESCs_Human1.09481109
116TP53_22573176_ChIP-Seq_HFKS_Human1.09377991
117MYC_22102868_ChIP-Seq_BL_Human1.09103561
118FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08418096
119POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07914665
120GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06178782
121* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05493004
122MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04885382
123TAF15_26573619_Chip-Seq_HEK293_Human1.04677736
124MAF_26560356_Chip-Seq_TH1_Human1.04438924
125CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04354846
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03875197
127CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02988268
128HTT_18923047_ChIP-ChIP_STHdh_Human1.01258204
129STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00542382
130UTX_26944678_Chip-Seq_JUKART_Human1.00458594
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99879524
132MYB_26560356_Chip-Seq_TH1_Human0.99034772
133CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99001005
134SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98905409
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98589432
136E2F1_21310950_ChIP-Seq_MCF-7_Human0.98004986
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97672406
138* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96884192
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95882826
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94818226
141PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93411856
142KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91937052
143EZH2_22144423_ChIP-Seq_EOC_Human0.91859199
144NANOG_19829295_ChIP-Seq_ESCs_Human0.91390789
145SOX2_19829295_ChIP-Seq_ESCs_Human0.91390789
146MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90728966
147IRF1_19129219_ChIP-ChIP_H3396_Human0.90616833
148KDM5A_27292631_Chip-Seq_BREAST_Human0.90614078
149CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88133540
150RNF2_27304074_Chip-Seq_NSC_Mouse0.87645795
151CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85269980
152PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84218490
153SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83401424
154GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82445950
155CBP_20019798_ChIP-Seq_JUKART_Human0.81764659
156IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81764659
157FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79978359
158FOXA1_25329375_ChIP-Seq_VCAP_Human0.79978359

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.41112960
2MP0002396_abnormal_hematopoietic_system3.33168422
3MP0002148_abnormal_hypersensitivity_rea3.18127782
4MP0005671_abnormal_response_to3.06182342
5MP0006292_abnormal_olfactory_placode2.94335689
6MP0009785_altered_susceptibility_to2.87324361
7MP0003136_yellow_coat_color2.83800120
8MP0003436_decreased_susceptibility_to2.78229926
9MP0002419_abnormal_innate_immunity2.60882779
10MP0005464_abnormal_platelet_physiology2.60448263
11MP0002837_dystrophic_cardiac_calcinosis2.58925898
12MP0005000_abnormal_immune_tolerance2.58891052
13MP0005025_abnormal_response_to2.54430226
14MP0003191_abnormal_cellular_cholesterol2.53984733
15MP0002938_white_spotting2.43474262
16MP0002452_abnormal_antigen_presenting2.39595707
17MP0002723_abnormal_immune_serum2.37602221
18MP0003646_muscle_fatigue2.35704840
19MP0000685_abnormal_immune_system2.34810357
20MP0001800_abnormal_humoral_immune2.33158411
21MP0002102_abnormal_ear_morphology2.32471600
22MP0002420_abnormal_adaptive_immunity2.27382369
23MP0001819_abnormal_immune_cell2.26536108
24MP0003880_abnormal_central_pattern2.23957398
25MP0003724_increased_susceptibility_to2.22590999
26MP0006082_CNS_inflammation2.22318027
27MP0003172_abnormal_lysosome_physiology2.17416657
28MP0001853_heart_inflammation2.16079806
29MP0008007_abnormal_cellular_replicative2.09573527
30MP0005410_abnormal_fertilization2.03713522
31MP0009333_abnormal_splenocyte_physiolog1.98030989
32MP0002398_abnormal_bone_marrow1.97254878
33MP0006072_abnormal_retinal_apoptosis1.97228357
34MP0003693_abnormal_embryo_hatching1.94737802
35MP0003763_abnormal_thymus_physiology1.93628125
36MP0001984_abnormal_olfaction1.92045597
37MP0000689_abnormal_spleen_morphology1.85216939
38MP0005397_hematopoietic_system_phenotyp1.84177878
39MP0001545_abnormal_hematopoietic_system1.84177878
40MP0002405_respiratory_system_inflammati1.81881017
41MP0000716_abnormal_immune_system1.81790422
42MP0000343_altered_response_to1.79026871
43MP0003283_abnormal_digestive_organ1.75623997
44MP0005387_immune_system_phenotype1.75413110
45MP0001790_abnormal_immune_system1.75413110
46MP0008058_abnormal_DNA_repair1.74187282
47MP0000490_abnormal_crypts_of1.74025216
48MP0004145_abnormal_muscle_electrophysio1.70978277
49MP0005174_abnormal_tail_pigmentation1.70198425
50MP0005058_abnormal_lysosome_morphology1.69230740
51MP0002429_abnormal_blood_cell1.67238634
52MP0001845_abnormal_inflammatory_respons1.65316493
53MP0002722_abnormal_immune_system1.62806097
54MP0009379_abnormal_foot_pigmentation1.62207932
55MP0002638_abnormal_pupillary_reflex1.62182242
56MP0001533_abnormal_skeleton_physiology1.56818908
57MP0008469_abnormal_protein_level1.56703760
58MP0010155_abnormal_intestine_physiology1.52105748
59MP0005253_abnormal_eye_physiology1.51305138
60MP0005551_abnormal_eye_electrophysiolog1.50880245
61MP0003075_altered_response_to1.45189314
62MP0004133_heterotaxia1.45147363
63MP0003787_abnormal_imprinting1.45019650
64MP0004147_increased_porphyrin_level1.44874718
65MP0000858_altered_metastatic_potential1.44534950
66MP0004808_abnormal_hematopoietic_stem1.44070962
67MP0001485_abnormal_pinna_reflex1.42749647
68MP0003718_maternal_effect1.42681964
69MP0003866_abnormal_defecation1.42146788
70MP0003123_paternal_imprinting1.41962311
71MP0004957_abnormal_blastocyst_morpholog1.39489678
72MP0009046_muscle_twitch1.39379814
73MP0001529_abnormal_vocalization1.38998096
74MP0003121_genomic_imprinting1.37189183
75MP0001986_abnormal_taste_sensitivity1.36798279
76MP0001968_abnormal_touch/_nociception1.36030555
77MP0003186_abnormal_redox_activity1.35856066
78MP0005075_abnormal_melanosome_morpholog1.34996626
79MP0002163_abnormal_gland_morphology1.30949829
80MP0001293_anophthalmia1.29189215
81MP0003011_delayed_dark_adaptation1.27845059
82MP0005166_decreased_susceptibility_to1.27292796
83MP0006035_abnormal_mitochondrial_morpho1.24192364
84MP0000631_abnormal_neuroendocrine_gland1.23644120
85MP0009745_abnormal_behavioral_response1.23064732
86MP0002234_abnormal_pharynx_morphology1.22402810
87MP0003195_calcinosis1.19677204
88MP0002272_abnormal_nervous_system1.18209979
89MP0000703_abnormal_thymus_morphology1.17949008
90MP0002006_tumorigenesis1.17829037
91MP0005310_abnormal_salivary_gland1.17618920
92MP0000465_gastrointestinal_hemorrhage1.17198146
93MP0003183_abnormal_peptide_metabolism1.16560053
94MP0003111_abnormal_nucleus_morphology1.16163984
95MP0010030_abnormal_orbit_morphology1.15726770
96MP0006054_spinal_hemorrhage1.15165617
97MP0001764_abnormal_homeostasis1.14847709
98MP0003567_abnormal_fetal_cardiomyocyte1.14252429
99MP0002166_altered_tumor_susceptibility1.14101294
100MP0004215_abnormal_myocardial_fiber1.12204516
101MP0005379_endocrine/exocrine_gland_phen1.11410213
102MP0001873_stomach_inflammation1.11335859
103MP0003656_abnormal_erythrocyte_physiolo1.11229335
104MP0003077_abnormal_cell_cycle1.11112552
105MP0004883_abnormal_blood_vessel1.10971008
106MP0002933_joint_inflammation1.10403528
107MP0005646_abnormal_pituitary_gland1.09793371
108MP0002095_abnormal_skin_pigmentation1.09790773
109MP0003937_abnormal_limbs/digits/tail_de1.08936153
110MP0002090_abnormal_vision1.08909767
111MP0006036_abnormal_mitochondrial_physio1.07426530
112MP0000749_muscle_degeneration1.03483924
113MP0004270_analgesia1.02789541
114MP0003137_abnormal_impulse_conducting1.02669954
115MP0005332_abnormal_amino_acid1.01676234
116MP0005645_abnormal_hypothalamus_physiol1.01626969
117MP0002734_abnormal_mechanical_nocicepti1.01408963
118MP0003122_maternal_imprinting1.01202498
119MP0010094_abnormal_chromosome_stability0.99681849
120MP0009764_decreased_sensitivity_to0.99066844
121MP0003786_premature_aging0.98535987
122MP0002064_seizures0.97983748
123MP0001661_extended_life_span0.97756868
124MP0003303_peritoneal_inflammation0.96660112
125MP0002751_abnormal_autonomic_nervous0.96292291
126MP0000647_abnormal_sebaceous_gland0.96092604
127MP0002160_abnormal_reproductive_system0.95453147
128MP0002736_abnormal_nociception_after0.95340797
129MP0003890_abnormal_embryonic-extraembry0.94463247
130MP0000778_abnormal_nervous_system0.94386391
131MP0003938_abnormal_ear_development0.93334467
132MP0000015_abnormal_ear_pigmentation0.92998264
133MP0003119_abnormal_digestive_system0.92145141
134MP0001542_abnormal_bone_strength0.91927995
135MP0008775_abnormal_heart_ventricle0.91098768
136MP0009840_abnormal_foam_cell0.90732009
137MP0000049_abnormal_middle_ear0.90596126
138MP0005187_abnormal_penis_morphology0.90205823
139MP0004142_abnormal_muscle_tone0.89773025
140MP0001188_hyperpigmentation0.89614516
141MP0008057_abnormal_DNA_replication0.88780086
142MP0000372_irregular_coat_pigmentation0.88657180
143MP0002132_abnormal_respiratory_system0.87174656
144MP0008004_abnormal_stomach_pH0.86871882
145MP0001486_abnormal_startle_reflex0.86469649
146MP0008789_abnormal_olfactory_epithelium0.86398477
147MP0004885_abnormal_endolymph0.85870322
148MP0002019_abnormal_tumor_incidence0.85794594
149MP0002557_abnormal_social/conspecific_i0.85336025
150MP0000313_abnormal_cell_death0.84271617
151MP0005390_skeleton_phenotype0.84249126
152MP0003941_abnormal_skin_development0.83523250
153MP0002210_abnormal_sex_determination0.82459999
154MP0008873_increased_physiological_sensi0.82055284
155MP0000249_abnormal_blood_vessel0.81518405
156MP0003279_aneurysm0.81344677
157MP0001905_abnormal_dopamine_level0.81151471
158MP0003806_abnormal_nucleotide_metabolis0.81033711
159MP0001324_abnormal_eye_pigmentation0.80749381
160MP0002233_abnormal_nose_morphology0.79788419
161MP0008995_early_reproductive_senescence0.79752902
162MP0002184_abnormal_innervation0.79248661
163MP0005391_vision/eye_phenotype0.79235606
164MP0002752_abnormal_somatic_nervous0.78443466
165MP0005171_absent_coat_pigmentation0.78126099
166MP0009697_abnormal_copulation0.77437337
167MP0005195_abnormal_posterior_eye0.77104672
168MP0005164_abnormal_response_to0.76369521
169MP0001663_abnormal_digestive_system0.76348555
170MP0009278_abnormal_bone_marrow0.76226914
171MP0001851_eye_inflammation0.72375326
172MP0003448_altered_tumor_morphology0.70284035
173MP0006276_abnormal_autonomic_nervous0.69556109
174MP0008932_abnormal_embryonic_tissue0.68993844
175MP0008872_abnormal_physiological_respon0.68965562
176MP0008877_abnormal_DNA_methylation0.68154888
177MP0005084_abnormal_gallbladder_morpholo0.66649950

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.05311218
2Abnormality of cells of the erythroid lineage (HP:0012130)4.66282632
3Thrombocytosis (HP:0001894)4.47508464
4Abnormal number of erythroid precursors (HP:0012131)4.27052073
5Recurrent bacterial skin infections (HP:0005406)4.26828650
6Agnosia (HP:0010524)3.99166479
7Systemic lupus erythematosus (HP:0002725)3.98618942
8Elevated erythrocyte sedimentation rate (HP:0003565)3.90785821
9Myositis (HP:0100614)3.74338223
10Reticulocytopenia (HP:0001896)3.72162623
11Glomerulonephritis (HP:0000099)3.27848774
12Aplastic anemia (HP:0001915)3.22845191
13Poor head control (HP:0002421)3.20489480
14Cerebral edema (HP:0002181)3.19967146
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.16374512
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.16374512
17Colon cancer (HP:0003003)3.04664680
18Vacuolated lymphocytes (HP:0001922)3.03160166
19IgM deficiency (HP:0002850)3.02915993
20Hepatocellular necrosis (HP:0001404)2.99173688
21Hyperinsulinemic hypoglycemia (HP:0000825)2.94474209
22Eczematoid dermatitis (HP:0000976)2.87735968
23Obstructive lung disease (HP:0006536)2.86919774
24Chronic obstructive pulmonary disease (HP:0006510)2.86919774
25Mitochondrial inheritance (HP:0001427)2.85611464
26Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.85270912
27Hypoglycemic coma (HP:0001325)2.83250018
28Type I transferrin isoform profile (HP:0003642)2.82251404
29Pancreatic fibrosis (HP:0100732)2.72184269
30Increased hepatocellular lipid droplets (HP:0006565)2.70654416
31Microvesicular hepatic steatosis (HP:0001414)2.70175757
32Hepatic necrosis (HP:0002605)2.67534193
33True hermaphroditism (HP:0010459)2.66148370
34Pancreatic cysts (HP:0001737)2.62994945
35Acute necrotizing encephalopathy (HP:0006965)2.62765552
36Macrocytic anemia (HP:0001972)2.61576514
37Exertional dyspnea (HP:0002875)2.57572841
38Pallor (HP:0000980)2.56096223
39Petechiae (HP:0000967)2.55246675
40Methylmalonic acidemia (HP:0002912)2.54502029
41Orchitis (HP:0100796)2.54162873
42Mediastinal lymphadenopathy (HP:0100721)2.52277334
43Renal Fanconi syndrome (HP:0001994)2.51151723
44Increased CSF lactate (HP:0002490)2.51059313
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.50234109
46Abnormality of glycolipid metabolism (HP:0010969)2.49499189
47Abnormality of liposaccharide metabolism (HP:0010968)2.49499189
48Abnormality of glycosphingolipid metabolism (HP:0004343)2.49499189
49Abnormal mitochondria in muscle tissue (HP:0008316)2.48068790
50Medial flaring of the eyebrow (HP:0010747)2.47965044
51Basal ganglia calcification (HP:0002135)2.46970604
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.46227305
53Axonal loss (HP:0003447)2.46041969
54Increased intramyocellular lipid droplets (HP:0012240)2.43398324
55Increased serum lactate (HP:0002151)2.43081410
56Abnormality of glycolysis (HP:0004366)2.41132713
57Dysostosis multiplex (HP:0000943)2.40913184
58Hypothermia (HP:0002045)2.39948716
59Lipid accumulation in hepatocytes (HP:0006561)2.39935469
60Recurrent skin infections (HP:0001581)2.37890231
61Reduced antithrombin III activity (HP:0001976)2.35758904
62Retrobulbar optic neuritis (HP:0100654)2.35656574
63Optic neuritis (HP:0100653)2.35656574
64Abnormality of midbrain morphology (HP:0002418)2.34198066
65Molar tooth sign on MRI (HP:0002419)2.34198066
66Leukodystrophy (HP:0002415)2.29658865
67Pulmonary fibrosis (HP:0002206)2.29498343
68Increased serum pyruvate (HP:0003542)2.29202381
69Abnormality of macrophages (HP:0004311)2.27217083
70Methylmalonic aciduria (HP:0012120)2.25116214
71Prolonged bleeding time (HP:0003010)2.23947346
72Abnormality of the labia minora (HP:0012880)2.20277236
73Hypoglycemic seizures (HP:0002173)2.19673418
74Increased muscle lipid content (HP:0009058)2.19250323
75Optic disc pallor (HP:0000543)2.18736791
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18487490
77Disinhibition (HP:0000734)2.18403780
78Generalized aminoaciduria (HP:0002909)2.17811160
79Increased cerebral lipofuscin (HP:0011813)2.17418703
803-Methylglutaconic aciduria (HP:0003535)2.16112384
81Respiratory difficulties (HP:0002880)2.14781940
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14686964
83Abnormal protein N-linked glycosylation (HP:0012347)2.14686964
84Abnormal protein glycosylation (HP:0012346)2.14686964
85Abnormal glycosylation (HP:0012345)2.14686964
86Progressive neurologic deterioration (HP:0002344)2.13410016
87Abnormality of alanine metabolism (HP:0010916)2.12030262
88Hyperalaninemia (HP:0003348)2.12030262
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12030262
90Ketoacidosis (HP:0001993)2.10083041
91Nephronophthisis (HP:0000090)2.09548024
92Gait imbalance (HP:0002141)2.08534422
93Abnormality of methionine metabolism (HP:0010901)2.07305023
94Abnormality of urine glucose concentration (HP:0011016)2.07119763
95Glycosuria (HP:0003076)2.07119763
96Congenital primary aphakia (HP:0007707)2.07030746
97Loss of speech (HP:0002371)2.06831838
98Abnormal platelet function (HP:0011869)2.06214911
99Impaired platelet aggregation (HP:0003540)2.06214911
100Meningitis (HP:0001287)2.04543500
101Lethargy (HP:0001254)2.03884414
102Arterial tortuosity (HP:0005116)2.03327616
103CNS demyelination (HP:0007305)2.03123466
104Abnormality of renal resorption (HP:0011038)1.99598047
105Congenital stationary night blindness (HP:0007642)1.98640448
106Hyperglycinemia (HP:0002154)1.98160137
107Acute encephalopathy (HP:0006846)1.97555215
108Nasal polyposis (HP:0100582)1.93986124
109Acute myeloid leukemia (HP:0004808)1.92232368
110Hepatosplenomegaly (HP:0001433)1.91848687
111Genital tract atresia (HP:0001827)1.90355143
112X-linked dominant inheritance (HP:0001423)1.89560545
113Nephrogenic diabetes insipidus (HP:0009806)1.89279429
114Exercise intolerance (HP:0003546)1.88587146
115Abnormality of the prostate (HP:0008775)1.88528450
116Sclerocornea (HP:0000647)1.88326412
117Dynein arm defect of respiratory motile cilia (HP:0012255)1.88298138
118Absent/shortened dynein arms (HP:0200106)1.88298138
119Abnormality of the nasal mucosa (HP:0000433)1.88184906
120Lactic acidosis (HP:0003128)1.87903438
121Large for gestational age (HP:0001520)1.87825055
122J-shaped sella turcica (HP:0002680)1.87732369
123Recurrent bronchitis (HP:0002837)1.87350905
124Epistaxis (HP:0000421)1.87183128
125Respiratory failure (HP:0002878)1.86521942
126Pulmonary infiltrates (HP:0002113)1.86115687
127Pancytopenia (HP:0001876)1.85114649
128Myokymia (HP:0002411)1.84907464
129Vaginal atresia (HP:0000148)1.84750864
130Symptomatic seizures (HP:0011145)1.84654663
131Chronic otitis media (HP:0000389)1.84047192
132Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83853769
133Dry hair (HP:0011359)1.83704721
134Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83199072
135Nonprogressive disorder (HP:0003680)1.82805007
136Purpura (HP:0000979)1.82556078
137Progressive macrocephaly (HP:0004481)1.81150692
138Muscle fiber atrophy (HP:0100295)1.80751715
139Recurrent viral infections (HP:0004429)1.80636563
140Recurrent gram-negative bacterial infections (HP:0005420)1.80050253
141Hyperglycinuria (HP:0003108)1.79529631
142Spondylolisthesis (HP:0003302)1.79062676
143Joint stiffness (HP:0001387)1.78537095
144Abnormality of serum amino acid levels (HP:0003112)1.78328392
145Beaking of vertebral bodies (HP:0004568)1.75754563
146Hyperphosphaturia (HP:0003109)1.74280590
147Exercise-induced muscle cramps (HP:0003710)1.74200181
148Esophageal atresia (HP:0002032)1.71355556
149Abnormality of the renal medulla (HP:0100957)1.70787851
150Gastrointestinal atresia (HP:0002589)1.70520816
151Septo-optic dysplasia (HP:0100842)1.69422119
152Male pseudohermaphroditism (HP:0000037)1.68710933
153Congenital, generalized hypertrichosis (HP:0004540)1.68426623
154Abnormality of glycine metabolism (HP:0010895)1.67281310
155Abnormality of serine family amino acid metabolism (HP:0010894)1.67281310
156Absent thumb (HP:0009777)1.66120116
157Hyperglycemia (HP:0003074)1.63697185
158Pancreatic islet-cell hyperplasia (HP:0004510)1.63649182
159Optic nerve hypoplasia (HP:0000609)1.63075807
160Dicarboxylic aciduria (HP:0003215)1.62277254
161Abnormality of dicarboxylic acid metabolism (HP:0010995)1.62277254
162Ketosis (HP:0001946)1.61652343
163Broad-based gait (HP:0002136)1.60774439
164Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60599156
165Meckel diverticulum (HP:0002245)1.60160035
166Anencephaly (HP:0002323)1.59565344
167Progressive microcephaly (HP:0000253)1.59503193
168Emotional lability (HP:0000712)1.59075717
169Intestinal atresia (HP:0011100)1.57201701
170Triphalangeal thumb (HP:0001199)1.56603301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.15693259
2BLK4.09547369
3VRK23.66091927
4FRK3.54490436
5TGFBR23.14880480
6NME22.87847558
7KIT2.56967024
8ZAK2.48240942
9EIF2AK12.46326392
10MAP3K122.31330647
11MAPKAPK32.27516445
12BMPR1B2.24224224
13WNK32.19516913
14CDK82.16953774
15OBSCN2.11345862
16MAP4K12.09799122
17CSF1R2.05776960
18NUAK12.05414648
19PHKG22.04612308
20PHKG12.04612308
21MAP2K72.01980830
22MAP4K21.99101556
23IRAK41.98537631
24TYK21.93258436
25SCYL21.91193552
26TAF11.90398077
27EEF2K1.89028533
28PLK31.85208240
29TEC1.81919456
30FLT31.81091919
31PIM21.79915159
32PINK11.74071146
33EIF2AK31.73423838
34CDC71.70945285
35GRK71.68288210
36CDK191.66529536
37RIPK41.62620823
38SRPK11.61145761
39ZAP701.60053408
40ADRBK21.59191753
41TBK11.58641432
42BTK1.57897051
43MAPKAPK51.57334597
44CASK1.56605832
45VRK11.55797106
46CSNK1G31.53244267
47FGFR21.48970064
48PLK21.47860389
49TXK1.47336307
50CSNK1G11.46322063
51GRK11.42514500
52BCKDK1.41943180
53MKNK21.41380523
54PASK1.37548363
55CSNK1G21.35599657
56MYLK1.32379978
57TTK1.29313688
58SYK1.22327764
59EPHA41.22319070
60TESK21.22137351
61TRIM281.20451058
62PRKG21.19591650
63TESK11.17759647
64DYRK21.17742427
65RPS6KB21.17741897
66CAMKK21.17285059
67MUSK1.16035481
68CSNK1A1L1.15620009
69IRAK31.15603627
70MAPK151.13306685
71IKBKE1.11881168
72TSSK61.11691556
73NEK11.11541585
74TLK11.10814557
75LYN1.10706564
76PBK1.10483277
77PLK11.09433381
78DAPK11.07519231
79KDR1.03587578
80MAP2K31.01700786
81TGFBR10.99015248
82WEE10.97329888
83BUB10.95135643
84BRSK20.93807929
85OXSR10.90421855
86PDK20.90294442
87FES0.89353734
88MATK0.89099551
89PAK40.86846913
90LIMK10.86034904
91LCK0.85211199
92PRKCG0.84992616
93JAK30.84828373
94ACVR1B0.82571547
95PIK3CG0.82061055
96CDK30.79621872
97ARAF0.78093679
98INSRR0.77471676
99IKBKB0.77123825
100MAP3K60.76949495
101STK38L0.67339359
102LRRK20.67221899
103MST40.66169145
104NME10.66064889
105MAP3K140.65695921
106CHEK20.65542926
107PAK30.63184193
108CCNB10.62404180
109WNK40.61648087
110STK100.60739889
111TNK20.59967661
112CSNK1A10.59951332
113AURKB0.59615159
114MAPK130.59286401
115MAP3K40.58968351
116BMPR20.56515125
117MAP2K40.55816572
118TAOK20.55720640
119BRSK10.55564542
120MAPK40.52734918
121ATM0.52666107
122RPS6KA50.52642166
123MOS0.51687238
124PRKCE0.51620011
125MAP3K30.51435487
126BCR0.51384998
127CSNK2A20.51299179
128MAP2K60.50392174
129DYRK30.50019007
130ILK0.49939972
131MAP3K110.49111801
132STK390.47242122
133PRKCD0.46522525
134MINK10.45079768
135HCK0.44360077
136AURKA0.42646431
137CAMK2A0.42546126
138MARK10.41918796
139IRAK10.41905112
140PNCK0.41135905
141EIF2AK20.39870985
142DAPK20.39850737
143CSNK1E0.39423446
144EPHB20.38451263
145ITK0.37593913
146STK30.37560805
147CSNK2A10.37123745
148MAPKAPK20.36624385
149CAMK2D0.36235256
150GRK50.36207925
151CDK70.36116725
152PRKACA0.35875672
153RPS6KA40.34867304
154CHEK10.34811987
155PDK40.33811213
156PDK30.33811213
157CSNK1D0.33611325
158CLK10.33543865
159DAPK30.32885582
160MAPK120.32099510
161TNIK0.31739483
162PLK40.31012802
163TRPM70.30224242
164CAMK10.29319289
165RAF10.28945576
166ATR0.28560354
167NEK90.27388295
168MKNK10.27372379
169ERN10.27167796

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.99459135
2DNA replication_Homo sapiens_hsa030303.35289949
3Proteasome_Homo sapiens_hsa030503.32829791
4Mismatch repair_Homo sapiens_hsa034302.95916079
5Other glycan degradation_Homo sapiens_hsa005112.51245343
6Oxidative phosphorylation_Homo sapiens_hsa001902.20542851
7RNA polymerase_Homo sapiens_hsa030202.15661205
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.15390200
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.07458364
10Parkinsons disease_Homo sapiens_hsa050122.04586273
11Cardiac muscle contraction_Homo sapiens_hsa042602.02850130
12Non-homologous end-joining_Homo sapiens_hsa034501.98046196
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96700908
14Protein export_Homo sapiens_hsa030601.94387944
15Nucleotide excision repair_Homo sapiens_hsa034201.92583244
16Pyrimidine metabolism_Homo sapiens_hsa002401.91409724
17Homologous recombination_Homo sapiens_hsa034401.86136774
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.74827052
19Propanoate metabolism_Homo sapiens_hsa006401.74099838
20Basal transcription factors_Homo sapiens_hsa030221.71936888
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69246830
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.68184261
23Butanoate metabolism_Homo sapiens_hsa006501.67210716
24Leishmaniasis_Homo sapiens_hsa051401.66923286
25Staphylococcus aureus infection_Homo sapiens_hsa051501.65559118
26Base excision repair_Homo sapiens_hsa034101.64809304
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64399767
28Fatty acid elongation_Homo sapiens_hsa000621.58743668
29Legionellosis_Homo sapiens_hsa051341.58146580
30Huntingtons disease_Homo sapiens_hsa050161.53567581
31Pertussis_Homo sapiens_hsa051331.51569394
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51453078
33Spliceosome_Homo sapiens_hsa030401.49511157
34Alzheimers disease_Homo sapiens_hsa050101.44235668
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43101785
36Antigen processing and presentation_Homo sapiens_hsa046121.40861003
37Osteoclast differentiation_Homo sapiens_hsa043801.38491598
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34380772
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.32613231
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32372987
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27430062
42B cell receptor signaling pathway_Homo sapiens_hsa046621.27262628
43Lysosome_Homo sapiens_hsa041421.26311282
44Phototransduction_Homo sapiens_hsa047441.25715313
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25093180
46Selenocompound metabolism_Homo sapiens_hsa004501.22593128
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19648912
48Hematopoietic cell lineage_Homo sapiens_hsa046401.18657016
49Primary immunodeficiency_Homo sapiens_hsa053401.17762472
50Vitamin B6 metabolism_Homo sapiens_hsa007501.17161610
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17007204
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15101070
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14625656
54N-Glycan biosynthesis_Homo sapiens_hsa005101.12292956
55Herpes simplex infection_Homo sapiens_hsa051681.11051133
56RNA degradation_Homo sapiens_hsa030181.09278520
57Measles_Homo sapiens_hsa051621.09134173
58Tryptophan metabolism_Homo sapiens_hsa003801.04778591
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04691669
60Peroxisome_Homo sapiens_hsa041461.04451921
61Tuberculosis_Homo sapiens_hsa051521.03879974
62* Purine metabolism_Homo sapiens_hsa002301.00628046
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99899974
64Sulfur relay system_Homo sapiens_hsa041220.96750899
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.96628868
66RNA transport_Homo sapiens_hsa030130.93742510
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92529665
68Collecting duct acid secretion_Homo sapiens_hsa049660.91624894
69Salmonella infection_Homo sapiens_hsa051320.91019608
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90997774
71Fatty acid degradation_Homo sapiens_hsa000710.86749739
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86723470
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86442805
74Rheumatoid arthritis_Homo sapiens_hsa053230.85794095
75Fatty acid metabolism_Homo sapiens_hsa012120.85299812
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83042886
77Shigellosis_Homo sapiens_hsa051310.82629721
78Phagosome_Homo sapiens_hsa041450.82111238
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80898944
80Epstein-Barr virus infection_Homo sapiens_hsa051690.80692384
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80560900
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80296776
83Carbon metabolism_Homo sapiens_hsa012000.80223168
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79754805
85beta-Alanine metabolism_Homo sapiens_hsa004100.79695493
86Arginine and proline metabolism_Homo sapiens_hsa003300.78747392
87Galactose metabolism_Homo sapiens_hsa000520.78680858
88Malaria_Homo sapiens_hsa051440.78333540
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77695305
90Sulfur metabolism_Homo sapiens_hsa009200.76735174
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.76397915
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76094849
93Folate biosynthesis_Homo sapiens_hsa007900.74856845
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.73637312
95Regulation of autophagy_Homo sapiens_hsa041400.73133153
96Nitrogen metabolism_Homo sapiens_hsa009100.72252356
97Influenza A_Homo sapiens_hsa051640.71924281
98Steroid biosynthesis_Homo sapiens_hsa001000.70771860
99Nicotine addiction_Homo sapiens_hsa050330.69508262
100Arachidonic acid metabolism_Homo sapiens_hsa005900.67186178
101Fanconi anemia pathway_Homo sapiens_hsa034600.66713621
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65980720
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65901374
104Apoptosis_Homo sapiens_hsa042100.64038882
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62345179
106Insulin secretion_Homo sapiens_hsa049110.62340413
107Circadian rhythm_Homo sapiens_hsa047100.61248256
108Pentose phosphate pathway_Homo sapiens_hsa000300.61147470
109Toxoplasmosis_Homo sapiens_hsa051450.58591975
110Biosynthesis of amino acids_Homo sapiens_hsa012300.57463201
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57421962
112African trypanosomiasis_Homo sapiens_hsa051430.55619861
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55080347
114Platelet activation_Homo sapiens_hsa046110.54145013
115Hepatitis B_Homo sapiens_hsa051610.52674545
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52144960
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.51526138
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51294478
119Oocyte meiosis_Homo sapiens_hsa041140.50100500
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49649896
121Fructose and mannose metabolism_Homo sapiens_hsa000510.49517074
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49177412
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48489753
124Hedgehog signaling pathway_Homo sapiens_hsa043400.48477512
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47343391
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46790119
127Glutathione metabolism_Homo sapiens_hsa004800.46760637
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45332358
129Cell cycle_Homo sapiens_hsa041100.43696965
130Systemic lupus erythematosus_Homo sapiens_hsa053220.39582401
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38680210
132mRNA surveillance pathway_Homo sapiens_hsa030150.38507466
133Basal cell carcinoma_Homo sapiens_hsa052170.38461448
134Chemical carcinogenesis_Homo sapiens_hsa052040.38081549
135* Metabolic pathways_Homo sapiens_hsa011000.36348130
136Retinol metabolism_Homo sapiens_hsa008300.36270666
137Chemokine signaling pathway_Homo sapiens_hsa040620.35892637
138Allograft rejection_Homo sapiens_hsa053300.35456132
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.35327538
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35212320
141Pyruvate metabolism_Homo sapiens_hsa006200.34676797
142Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34100693
143Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33924255
144Linoleic acid metabolism_Homo sapiens_hsa005910.32017528
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.31678031
146Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31561569
147One carbon pool by folate_Homo sapiens_hsa006700.31062482
148Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30109171
149Mineral absorption_Homo sapiens_hsa049780.29594101
150T cell receptor signaling pathway_Homo sapiens_hsa046600.28510517
151Lysine degradation_Homo sapiens_hsa003100.28271162
152Tyrosine metabolism_Homo sapiens_hsa003500.28001874
153Synaptic vesicle cycle_Homo sapiens_hsa047210.27995303
154Prion diseases_Homo sapiens_hsa050200.27986398
155Taste transduction_Homo sapiens_hsa047420.27962053
156p53 signaling pathway_Homo sapiens_hsa041150.25317909
157Circadian entrainment_Homo sapiens_hsa047130.23673414
158Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23316342

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