NTRK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenol-containing compound catabolic process (GO:0019336)9.23079380
2* detection of temperature stimulus involved in sensory perception of pain (GO:0050965)8.89514385
3* detection of temperature stimulus involved in sensory perception (GO:0050961)8.89514385
4negative regulation of calcium ion transport into cytosol (GO:0010523)7.03593160
5neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)6.76002677
6behavioral response to nicotine (GO:0035095)6.66924807
7proline transport (GO:0015824)6.60534413
8cell migration in hindbrain (GO:0021535)6.18960483
9negative regulation of dendrite morphogenesis (GO:0050774)5.78176000
10neurofilament cytoskeleton organization (GO:0060052)5.75949897
11peripheral nervous system neuron development (GO:0048935)5.48405895
12response to pain (GO:0048265)5.38648827
13negative regulation of microtubule polymerization (GO:0031115)5.28667422
14behavioral response to ethanol (GO:0048149)5.19394907
15pyrimidine ribonucleoside catabolic process (GO:0046133)4.67890476
16neuronal action potential (GO:0019228)4.55820539
17negative regulation of bone resorption (GO:0045779)4.54756377
18calcium-mediated signaling using intracellular calcium source (GO:0035584)4.38400456
19synaptic vesicle maturation (GO:0016188)4.37511393
20regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.35933211
21cellular response to interleukin-15 (GO:0071350)4.26478430
22response to histamine (GO:0034776)4.21363630
23positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.20483753
24enteric nervous system development (GO:0048484)4.20410652
25DNA deamination (GO:0045006)4.17471191
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.16776293
27positive regulation of granulocyte differentiation (GO:0030854)4.04606787
28regulation of T cell chemotaxis (GO:0010819)4.02402171
29positive regulation of T cell chemotaxis (GO:0010820)4.02402171
30mitochondrion transport along microtubule (GO:0047497)3.96360044
31establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.96360044
32negative regulation by host of viral transcription (GO:0043922)3.95115105
33negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.94593455
34protoporphyrinogen IX biosynthetic process (GO:0006782)3.94473406
35polyketide metabolic process (GO:0030638)3.93441409
36doxorubicin metabolic process (GO:0044598)3.93441409
37daunorubicin metabolic process (GO:0044597)3.93441409
38response to interleukin-15 (GO:0070672)3.90480630
39establishment of mitochondrion localization (GO:0051654)3.89828531
40negative regulation of smooth muscle contraction (GO:0045986)3.86388001
41synaptic transmission, cholinergic (GO:0007271)3.83857975
42regulation of lymphocyte chemotaxis (GO:1901623)3.74980432
43protoporphyrinogen IX metabolic process (GO:0046501)3.73691610
44neuromuscular synaptic transmission (GO:0007274)3.73109340
45definitive hemopoiesis (GO:0060216)3.70593868
46negative regulation of dendrite development (GO:2000171)3.69373002
47negative regulation of bone remodeling (GO:0046851)3.68620858
48G-protein coupled receptor internalization (GO:0002031)3.68288809
49membrane depolarization during action potential (GO:0086010)3.67919563
50regulation of RIG-I signaling pathway (GO:0039535)3.67294975
51* sympathetic nervous system development (GO:0048485)3.67018742
52positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.64823890
53negative regulation of epidermis development (GO:0045683)3.63392642
54positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.61934600
55positive regulation of erythrocyte differentiation (GO:0045648)3.60503487
56folic acid-containing compound biosynthetic process (GO:0009396)3.60374495
57regulation of glucose import in response to insulin stimulus (GO:2001273)3.54693425
58nuclear pore organization (GO:0006999)3.52724207
59nuclear pore complex assembly (GO:0051292)3.50942955
60positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.49578602
61granulocyte differentiation (GO:0030851)3.46582547
62peristalsis (GO:0030432)3.46028115
63* response to water (GO:0009415)3.45219806
64response to acidic pH (GO:0010447)3.45146316
65erythrocyte maturation (GO:0043249)3.43728926
66positive regulation of B cell differentiation (GO:0045579)3.40364006
67positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.36971047
68negative regulation of neurological system process (GO:0031645)3.34508016
69negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.32744777
70positive regulation of natural killer cell mediated immunity (GO:0002717)3.31081189
71catechol-containing compound biosynthetic process (GO:0009713)3.30831462
72catecholamine biosynthetic process (GO:0042423)3.30831462
73regulation of erythrocyte differentiation (GO:0045646)3.28666163
74substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.28614888
75substrate-independent telencephalic tangential migration (GO:0021826)3.28614888
76cell communication involved in cardiac conduction (GO:0086065)3.26864239
77coenzyme catabolic process (GO:0009109)3.23016365
78negative regulation of heart rate (GO:0010459)3.22853929
79oxygen transport (GO:0015671)3.21994394
80response to dietary excess (GO:0002021)3.21460893
81negative regulation of interleukin-2 production (GO:0032703)3.19628757
82multicellular organismal response to stress (GO:0033555)3.19236522
83modulation by host of viral transcription (GO:0043921)3.19041944
84modulation by host of symbiont transcription (GO:0052472)3.19041944
85positive regulation of megakaryocyte differentiation (GO:0045654)3.18671704
86positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.17195287
87dopamine metabolic process (GO:0042417)3.16788705
88negative regulation of erythrocyte differentiation (GO:0045647)3.16787356
89neurotransmitter catabolic process (GO:0042135)3.15326372
90protein polyglutamylation (GO:0018095)3.11680057
91norepinephrine metabolic process (GO:0042415)3.10507301
92microtubule depolymerization (GO:0007019)3.07557844
93negative regulation of tissue remodeling (GO:0034104)3.07050441
94adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.06454418
95melanosome transport (GO:0032402)3.06091965
96action potential (GO:0001508)3.05452949
97alanine transport (GO:0032328)3.05361878
98negative regulation of cytosolic calcium ion concentration (GO:0051481)3.04232989
99regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.02743364
100positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.02319588
101axon cargo transport (GO:0008088)3.00572135
102glutamate secretion (GO:0014047)3.00539415
103positive regulation of growth hormone secretion (GO:0060124)3.00307219
104negative regulation of potassium ion transmembrane transport (GO:1901380)3.00222054
105positive regulation of potassium ion transmembrane transport (GO:1901381)3.00043680
106gas transport (GO:0015669)2.99536608
107modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.99256475
108regulation of cardiac muscle cell apoptotic process (GO:0010665)2.98472552
109mRNA cleavage (GO:0006379)2.95469438
110maintenance of protein location in nucleus (GO:0051457)2.95092449
111pore complex assembly (GO:0046931)2.93821752
112regulation of chronic inflammatory response (GO:0002676)2.93713431
113retinal ganglion cell axon guidance (GO:0031290)2.92335291
114activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.90288977
115Arp2/3 complex-mediated actin nucleation (GO:0034314)2.88549319
116establishment of melanosome localization (GO:0032401)2.88254019
117positive regulation of hormone biosynthetic process (GO:0046886)2.87514165
118regulation of synaptic vesicle exocytosis (GO:2000300)2.87340321
119pigment granule transport (GO:0051904)2.87060809
120positive regulation of odontogenesis (GO:0042482)2.86591730
121positive regulation of glycolytic process (GO:0045821)2.85930597
122regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.85921164
123dopamine biosynthetic process (GO:0042416)2.84443159
124erythrocyte development (GO:0048821)2.83437481
125iron coordination entity transport (GO:1901678)2.81377752
126urinary tract smooth muscle contraction (GO:0014848)2.80515096
127dopamine receptor signaling pathway (GO:0007212)2.79916176
128positive regulation of axon extension (GO:0045773)2.79059018
129phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.78810505
130tolerance induction (GO:0002507)2.77575052
131bundle of His cell to Purkinje myocyte communication (GO:0086069)2.76305727
132sodium ion transmembrane transport (GO:0035725)2.75708645
133catecholamine transport (GO:0051937)2.75265596
134positive regulation of transcription regulatory region DNA binding (GO:2000679)2.71760810
135establishment of pigment granule localization (GO:0051905)2.70898731
136positive regulation of protein sumoylation (GO:0033235)2.70702174
137positive regulation of macrophage differentiation (GO:0045651)2.70356300
138cytidine metabolic process (GO:0046087)2.68812687
139cytidine catabolic process (GO:0006216)2.68812687
140cytidine deamination (GO:0009972)2.68812687
141synaptic vesicle exocytosis (GO:0016079)2.68688919
142regulation of hair follicle development (GO:0051797)2.68661736
143regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.67529222
144regulation of mitotic spindle checkpoint (GO:1903504)2.67529222
145regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.67238353
146regulation of amyloid precursor protein catabolic process (GO:1902991)2.65946949
147auditory behavior (GO:0031223)2.65708713
148negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.65106495
149negative regulation of catecholamine secretion (GO:0033604)2.65075974
150organelle transport along microtubule (GO:0072384)2.64295193
151regulation of potassium ion transmembrane transporter activity (GO:1901016)2.63440774
152neuronal action potential propagation (GO:0019227)2.63337827
153regulation of striated muscle cell apoptotic process (GO:0010662)2.63216956
154alpha-beta T cell differentiation involved in immune response (GO:0002293)2.63147501
155alpha-beta T cell activation involved in immune response (GO:0002287)2.63147501
156T cell differentiation involved in immune response (GO:0002292)2.63147501
157membrane budding (GO:0006900)2.61542303
158melanosome localization (GO:0032400)2.60735316
159regulation of NFAT protein import into nucleus (GO:0051532)2.60419920
160tachykinin receptor signaling pathway (GO:0007217)2.60274459
161peptidyl-threonine dephosphorylation (GO:0035970)2.59302173
162regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.58561929
163regulation of circadian sleep/wake cycle (GO:0042749)2.58561929
164regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.54091556
165regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.54091556
166termination of RNA polymerase II transcription (GO:0006369)2.52177102
167diterpenoid biosynthetic process (GO:0016102)2.51169766
168T-helper cell differentiation (GO:0042093)2.46010524
169CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.46010524
170regulation of synapse structural plasticity (GO:0051823)2.45995110
171metallo-sulfur cluster assembly (GO:0031163)2.44666109
172iron-sulfur cluster assembly (GO:0016226)2.44666109
173megakaryocyte development (GO:0035855)2.43964518
174mRNA transcription from RNA polymerase II promoter (GO:0042789)2.43697622
175replication fork processing (GO:0031297)2.42620317
176regulation of B cell receptor signaling pathway (GO:0050855)2.42281924
177regulation of interleukin-2 biosynthetic process (GO:0045076)2.41792413
178regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.41142190
179glycine transport (GO:0015816)2.41025989
180arginine catabolic process (GO:0006527)2.40573107
181viral mRNA export from host cell nucleus (GO:0046784)2.38970998
182synaptic transmission, dopaminergic (GO:0001963)2.38048699
183regulation of exit from mitosis (GO:0007096)2.37201040
184negative regulation of reactive oxygen species metabolic process (GO:2000378)2.36043466
185peptidyl-arginine omega-N-methylation (GO:0035247)2.35846514
186positive regulation of calcium-mediated signaling (GO:0050850)2.35695121
187* detection of temperature stimulus (GO:0016048)10.0361336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human5.77619287
2E2F7_22180533_ChIP-Seq_HELA_Human5.34775725
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.60571806
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.60571806
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.60571806
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.46041505
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.30918810
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94612797
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86810723
10GATA1_19941826_ChIP-Seq_K562_Human2.77664534
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.70298964
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.63705430
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60679446
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.59767219
15EZH2_22144423_ChIP-Seq_EOC_Human2.58002543
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.34634324
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.34124291
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33782837
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.27680387
20SCL_19346495_ChIP-Seq_HPC-7_Human2.18679494
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.18304241
22* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.17624637
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17483042
24NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.17443915
25ZFP281_18757296_ChIP-ChIP_E14_Mouse2.16463733
26ETS1_20019798_ChIP-Seq_JURKAT_Human2.14540649
27KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.11523731
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.10483381
29EST1_17652178_ChIP-ChIP_JURKAT_Human2.09504345
30REST_21632747_ChIP-Seq_MESCs_Mouse2.07577002
31EZH2_18974828_ChIP-Seq_MESCs_Mouse2.07239617
32RNF2_18974828_ChIP-Seq_MESCs_Mouse2.07239617
33NR3C1_23031785_ChIP-Seq_PC12_Mouse2.06033401
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.05962807
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.05012804
36* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99039378
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98738213
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.97909247
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.97073362
40SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.96801013
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95038226
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95001878
43* GATA2_19941826_ChIP-Seq_K562_Human1.94124256
44VDR_23849224_ChIP-Seq_CD4+_Human1.92872513
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.92598824
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88326279
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85338291
48* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85139491
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84516868
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83860875
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.83059920
52NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.82506068
53FOXP3_21729870_ChIP-Seq_TREG_Human1.82179981
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81787303
55KDM2B_26808549_Chip-Seq_K562_Human1.80190572
56* NCOR1_26117541_ChIP-Seq_K562_Human1.78951580
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77415296
58* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75501223
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74067266
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71581492
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69808492
62ZNF263_19887448_ChIP-Seq_K562_Human1.68840343
63SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.68332894
64IRF1_19129219_ChIP-ChIP_H3396_Human1.68064560
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67146389
66* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66505939
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66270663
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64735781
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64257047
70NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59360708
71MYB_26560356_Chip-Seq_TH2_Human1.59276267
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.58609625
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58557281
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57682648
75MYC_18940864_ChIP-ChIP_HL60_Human1.57331506
76MYC_22102868_ChIP-Seq_BL_Human1.56762341
77CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.56623012
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.55184524
79TTF2_22483619_ChIP-Seq_HELA_Human1.53587891
80MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53450730
81MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52140392
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52048448
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.49701806
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47241246
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45777764
86* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44620473
87TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.42856978
88RUNX_20019798_ChIP-Seq_JUKART_Human1.40253818
89XRN2_22483619_ChIP-Seq_HELA_Human1.40252298
90ELK1_19687146_ChIP-ChIP_HELA_Human1.40224179
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39735702
92RARB_27405468_Chip-Seq_BRAIN_Mouse1.37580521
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36895902
94* CTCF_27219007_Chip-Seq_Bcells_Human1.35292282
95* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34551859
96RNF2_27304074_Chip-Seq_NSC_Mouse1.34511563
97PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.34434318
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32440896
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31723328
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31574800
101SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27940638
102MAF_26560356_Chip-Seq_TH1_Human1.27679231
103STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26199464
104DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26189285
105VDR_22108803_ChIP-Seq_LS180_Human1.25909492
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25241617
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25165951
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24629214
109RNF2_27304074_Chip-Seq_ESCs_Mouse1.24600477
110FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23696281
111DCP1A_22483619_ChIP-Seq_HELA_Human1.22999157
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22405305
113* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.21408805
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21377292
115STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21001317
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20823114
117MYB_26560356_Chip-Seq_TH1_Human1.19431744
118GABP_19822575_ChIP-Seq_HepG2_Human1.19336712
119YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19306690
120TET1_21490601_ChIP-Seq_MESCs_Mouse1.19198695
121NANOG_18692474_ChIP-Seq_MEFs_Mouse1.18149241
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18094315
123TCF3_18692474_ChIP-Seq_MESCs_Mouse1.18026233
124WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17608384
125PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17411089
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17305381
127KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16923188
128HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16915727
129TP53_20018659_ChIP-ChIP_R1E_Mouse1.16172778
130TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15631735
131GATA3_27048872_Chip-Seq_THYMUS_Human1.15471016
132IGF1R_20145208_ChIP-Seq_DFB_Human1.15358918
133EZH2_27294783_Chip-Seq_ESCs_Mouse1.14440851
134ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13698429
135RING1B_27294783_Chip-Seq_NPCs_Mouse1.13325531
136LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12933151
137SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12927720
138ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12686422
139NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.12449205
140IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11987369
141GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11829823
142CIITA_25753668_ChIP-Seq_RAJI_Human1.11780959
143NANOG_18692474_ChIP-Seq_MESCs_Mouse1.11047984
144DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09848577
145ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08974064
146ZNF274_21170338_ChIP-Seq_K562_Hela1.07661077
147GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07270781
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07193949
149LXR_22292898_ChIP-Seq_THP-1_Human1.06573944
150ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06403559
151UTX_26944678_Chip-Seq_JUKART_Human1.05233277
152ESR1_20079471_ChIP-ChIP_T-47D_Human1.04179203
153KDM5A_27292631_Chip-Seq_BREAST_Human1.03854396
154SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03370040
155SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03269729
156CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03229324
157CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01979773
158YY1_22570637_ChIP-Seq_MALME-3M_Human1.01849984
159TP53_22573176_ChIP-Seq_HFKS_Human1.01781791
160BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01347695
161GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00480741
162YY1_21170310_ChIP-Seq_MESCs_Mouse0.99046625
163POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98581110
164GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98554268
165CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97406410
166* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96217387
167SPI1_23547873_ChIP-Seq_NB4_Human0.94967271
168TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94962000
169NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94809920
170FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94514069
171* GATA6_21074721_ChIP-Seq_CACO-2_Human0.94271291
172* MAF_26560356_Chip-Seq_TH2_Human0.94122801
173* EED_16625203_ChIP-ChIP_MESCs_Mouse0.93978021
174NANOG_16518401_ChIP-PET_MESCs_Mouse0.92278452
175MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91218419
176SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91182431
177* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91138571
178SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90688231
179FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.90377084
180OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89636244
181AHR_22903824_ChIP-Seq_MCF-7_Human0.89286732
182NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88794385
183ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88739649
184EGR1_19374776_ChIP-ChIP_THP-1_Human0.88167298
185SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.87539195
186E2F1_17053090_ChIP-ChIP_MCF-7_Human0.87516407
187POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.86090039
188ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85931464
189ELK3_25401928_ChIP-Seq_HUVEC_Human0.85542159
190OCT4_19829295_ChIP-Seq_ESCs_Human0.84999577
191TAF15_26573619_Chip-Seq_HEK293_Human0.84835766
192GATA3_26560356_Chip-Seq_TH2_Human0.82070329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception6.96209078
2MP0004858_abnormal_nervous_system6.62892427
3MP0002822_catalepsy4.97993749
4MP0001968_abnormal_touch/_nociception4.47641790
5* MP0006276_abnormal_autonomic_nervous4.44803940
6* MP0002733_abnormal_thermal_nociception3.83304957
7MP0004147_increased_porphyrin_level3.75068613
8* MP0001970_abnormal_pain_threshold3.48498624
9MP0002736_abnormal_nociception_after3.20574462
10* MP0002734_abnormal_mechanical_nocicepti3.07261880
11MP0001986_abnormal_taste_sensitivity3.03976316
12MP0002009_preneoplasia3.00381086
13* MP0004270_analgesia2.92894188
14MP0001188_hyperpigmentation2.89307391
15MP0010386_abnormal_urinary_bladder2.71870297
16MP0005671_abnormal_response_to2.51560175
17MP0008995_early_reproductive_senescence2.44268578
18* MP0002751_abnormal_autonomic_nervous2.43019006
19MP0002184_abnormal_innervation2.39292982
20MP0008058_abnormal_DNA_repair2.02225777
21MP0005646_abnormal_pituitary_gland2.01012039
22MP0001348_abnormal_lacrimal_gland1.93356346
23MP0003567_abnormal_fetal_cardiomyocyte1.86490598
24MP0003786_premature_aging1.84754187
25MP0003122_maternal_imprinting1.84391266
26MP0003693_abnormal_embryo_hatching1.79362952
27MP0004859_abnormal_synaptic_plasticity1.79114115
28MP0008057_abnormal_DNA_replication1.77244535
29MP0009745_abnormal_behavioral_response1.76622378
30MP0009333_abnormal_splenocyte_physiolog1.75782236
31MP0002272_abnormal_nervous_system1.74190691
32MP0003011_delayed_dark_adaptation1.71426870
33MP0001270_distended_abdomen1.67776063
34MP0000955_abnormal_spinal_cord1.66184427
35MP0004145_abnormal_muscle_electrophysio1.65354637
36MP0001905_abnormal_dopamine_level1.61711025
37MP0005499_abnormal_olfactory_system1.61226892
38MP0005394_taste/olfaction_phenotype1.61226892
39MP0002638_abnormal_pupillary_reflex1.60310139
40MP0003763_abnormal_thymus_physiology1.57879709
41MP0003635_abnormal_synaptic_transmissio1.57741901
42MP0006072_abnormal_retinal_apoptosis1.56054138
43MP0002398_abnormal_bone_marrow1.54577150
44MP0002572_abnormal_emotion/affect_behav1.53208616
45MP0010094_abnormal_chromosome_stability1.52554595
46MP0008872_abnormal_physiological_respon1.50919758
47MP0009046_muscle_twitch1.50677915
48MP0003866_abnormal_defecation1.49881717
49MP0003183_abnormal_peptide_metabolism1.49696099
50MP0001440_abnormal_grooming_behavior1.49231816
51MP0005464_abnormal_platelet_physiology1.45618830
52MP0003329_amyloid_beta_deposits1.42729204
53MP0003111_abnormal_nucleus_morphology1.41031409
54MP0004811_abnormal_neuron_physiology1.40900570
55MP0002909_abnormal_adrenal_gland1.40379660
56MP0002102_abnormal_ear_morphology1.39411292
57MP0002063_abnormal_learning/memory/cond1.39241505
58* MP0002067_abnormal_sensory_capabilities1.37320329
59MP0000703_abnormal_thymus_morphology1.36621142
60MP0001727_abnormal_embryo_implantation1.36057848
61MP0000538_abnormal_urinary_bladder1.33800182
62MP0002254_reproductive_system_inflammat1.28820420
63MP0002332_abnormal_exercise_endurance1.28096127
64MP0010307_abnormal_tumor_latency1.27523995
65MP0002064_seizures1.27504272
66MP0000465_gastrointestinal_hemorrhage1.23606396
67MP0005253_abnormal_eye_physiology1.22814153
68MP0002722_abnormal_immune_system1.22356269
69MP0000689_abnormal_spleen_morphology1.20525590
70MP0004883_abnormal_blood_vessel1.19933933
71* MP0002723_abnormal_immune_serum1.12438949
72MP0000749_muscle_degeneration1.12353522
73MP0004957_abnormal_blastocyst_morpholog1.10490590
74* MP0002429_abnormal_blood_cell1.09810839
75MP0002127_abnormal_cardiovascular_syste1.08857497
76MP0005386_behavior/neurological_phenoty1.07282082
77MP0004924_abnormal_behavior1.07282082
78MP0001542_abnormal_bone_strength1.07149272
79* MP0002882_abnormal_neuron_morphology1.04824934
80MP0001502_abnormal_circadian_rhythm1.03793179
81MP0003077_abnormal_cell_cycle1.03573269
82MP0004085_abnormal_heartbeat1.03309818
83MP0006035_abnormal_mitochondrial_morpho1.03105785
84MP0000778_abnormal_nervous_system1.02929499
85MP0008874_decreased_physiological_sensi1.01322282
86MP0003633_abnormal_nervous_system0.99534055
87* MP0002420_abnormal_adaptive_immunity0.99372082
88* MP0002752_abnormal_somatic_nervous0.99212181
89* MP0001819_abnormal_immune_cell0.99141360
90MP0001919_abnormal_reproductive_system0.97604416
91* MP0000716_abnormal_immune_system0.97586852
92MP0003656_abnormal_erythrocyte_physiolo0.96188372
93MP0005645_abnormal_hypothalamus_physiol0.96164078
94MP0001835_abnormal_antigen_presentation0.95714894
95MP0005000_abnormal_immune_tolerance0.95225076
96MP0005075_abnormal_melanosome_morpholog0.94829126
97MP0005647_abnormal_sex_gland0.94069579
98MP0002653_abnormal_ependyma_morphology0.93708316
99MP0000534_abnormal_ureter_morphology0.92793911
100* MP0001800_abnormal_humoral_immune0.91837247
101MP0004264_abnormal_extraembryonic_tissu0.91778285
102MP0002210_abnormal_sex_determination0.90187443
103MP0002396_abnormal_hematopoietic_system0.89870103
104MP0003718_maternal_effect0.88634628
105MP0001119_abnormal_female_reproductive0.87034780
106MP0009379_abnormal_foot_pigmentation0.86835819
107MP0004142_abnormal_muscle_tone0.86688887
108MP0002166_altered_tumor_susceptibility0.85024871
109MP0005083_abnormal_biliary_tract0.84853515
110MP0001756_abnormal_urination0.83914624
111MP0005397_hematopoietic_system_phenotyp0.83693092
112MP0001545_abnormal_hematopoietic_system0.83693092
113MP0001501_abnormal_sleep_pattern0.81326770
114MP0002229_neurodegeneration0.81231626
115MP0002019_abnormal_tumor_incidence0.80043336
116MP0008007_abnormal_cellular_replicative0.79037386
117MP0006036_abnormal_mitochondrial_physio0.79023442
118MP0008789_abnormal_olfactory_epithelium0.79011848
119MP0008932_abnormal_embryonic_tissue0.78086265
120MP0004742_abnormal_vestibular_system0.78042586
121MP0003631_nervous_system_phenotype0.78000774
122MP0002163_abnormal_gland_morphology0.77937335
123MP0003646_muscle_fatigue0.77607093
124MP0000653_abnormal_sex_gland0.77351716
125MP0008569_lethality_at_weaning0.76233638
126MP0001790_abnormal_immune_system0.75881540
127MP0005387_immune_system_phenotype0.75881540
128MP0005310_abnormal_salivary_gland0.75813504
129* MP0002066_abnormal_motor_capabilities/c0.75682787
130MP0001929_abnormal_gametogenesis0.75168917
131MP0003634_abnormal_glial_cell0.75098462
132MP0001529_abnormal_vocalization0.74912029
133MP0008260_abnormal_autophagy0.74703693
134MP0003724_increased_susceptibility_to0.74651450
135MP0001873_stomach_inflammation0.74598595
136MP0003890_abnormal_embryonic-extraembry0.74514232
137MP0005423_abnormal_somatic_nervous0.74182086
138MP0005410_abnormal_fertilization0.73332790
139MP0002877_abnormal_melanocyte_morpholog0.73331809
140MP0006292_abnormal_olfactory_placode0.71175198
141MP0000313_abnormal_cell_death0.70262406
142MP0000751_myopathy0.69453205
143MP0001661_extended_life_span0.68786721
144MP0003221_abnormal_cardiomyocyte_apopto0.68468623
145MP0008775_abnormal_heart_ventricle0.67944492
146MP0003698_abnormal_male_reproductive0.67095319
147MP0001145_abnormal_male_reproductive0.66616104
148MP0005391_vision/eye_phenotype0.66567075
149MP0009764_decreased_sensitivity_to0.66263477
150MP0001984_abnormal_olfaction0.66208400
151MP0002557_abnormal_social/conspecific_i0.65903074
152MP0000747_muscle_weakness0.65116260
153MP0002160_abnormal_reproductive_system0.64334563
154MP0000604_amyloidosis0.64008856
155MP0009765_abnormal_xenobiotic_induced0.62885583
156MP0003942_abnormal_urinary_system0.62087406
157* MP0002452_abnormal_antigen_presenting0.62009753
158MP0000762_abnormal_tongue_morphology0.58915532
159MP0002269_muscular_atrophy0.58659310
160MP0008770_decreased_survivor_rate0.56562764
161MP0003632_abnormal_nervous_system0.56213202
162MP0003938_abnormal_ear_development0.54430603
163MP0001943_abnormal_respiration0.53751790
164MP0001486_abnormal_startle_reflex0.52928508
165MP0003121_genomic_imprinting0.51577112
166MP0003283_abnormal_digestive_organ0.50689858
167MP0003279_aneurysm0.49150401
168MP0005535_abnormal_body_temperature0.48786653
169* MP0000759_abnormal_skeletal_muscle0.47835826
170MP0002069_abnormal_eating/drinking_beha0.47402320
171MP0001299_abnormal_eye_distance/0.46988093
172MP0001963_abnormal_hearing_physiology0.46383978
173* MP0005197_abnormal_uvea_morphology0.43366008
174MP0005257_abnormal_intraocular_pressure0.43276364

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)8.07539928
2Ulnar claw (HP:0001178)6.44829348
3Myokymia (HP:0002411)5.77697217
4Abnormality of the heme biosynthetic pathway (HP:0010472)5.39533679
5Action tremor (HP:0002345)5.18041709
6Abnormality of the lower motor neuron (HP:0002366)4.62736711
7Decreased number of large peripheral myelinated nerve fibers (HP:0003387)4.15320986
8Amblyopia (HP:0000646)4.14467300
9Termporal pattern (HP:0011008)4.12281075
10Insidious onset (HP:0003587)4.12281075
11Bilateral microphthalmos (HP:0007633)3.90326113
12* Abnormal autonomic nervous system physiology (HP:0012332)3.81255851
13Abnormal gallbladder physiology (HP:0012438)3.68813638
14Cholecystitis (HP:0001082)3.68813638
15Abnormality of the corticospinal tract (HP:0002492)3.66379058
16* Impaired pain sensation (HP:0007328)3.52243511
17* Abnormality of pain sensation (HP:0010832)3.52243511
18Steppage gait (HP:0003376)3.44278329
19Reticulocytosis (HP:0001923)3.43642186
20Myotonia (HP:0002486)3.42372145
21Segmental peripheral demyelination/remyelination (HP:0003481)3.36012134
22T lymphocytopenia (HP:0005403)3.34968998
23Abnormality of T cell number (HP:0011839)3.28448525
24Pheochromocytoma (HP:0002666)3.22116602
25Atonic seizures (HP:0010819)3.15813142
26Febrile seizures (HP:0002373)3.09394940
27Hepatoblastoma (HP:0002884)3.08130363
28Focal seizures (HP:0007359)3.07566985
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.06591786
30Abnormality of macular pigmentation (HP:0008002)3.00932545
31Foot dorsiflexor weakness (HP:0009027)2.97337407
32Hammertoe (HP:0001765)2.96777080
33Failure to thrive in infancy (HP:0001531)2.95986504
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.95885059
35Neonatal hypoglycemia (HP:0001998)2.92901357
36Neuroendocrine neoplasm (HP:0100634)2.91566131
37Granulocytopenia (HP:0001913)2.89294869
38* Orthostatic hypotension (HP:0001278)2.88549028
39Distal sensory impairment (HP:0002936)2.86217378
40Type 2 muscle fiber atrophy (HP:0003554)2.85429294
41Bradycardia (HP:0001662)2.84965925
42Supranuclear gaze palsy (HP:0000605)2.82187648
43Ankle clonus (HP:0011448)2.81832835
44EMG: neuropathic changes (HP:0003445)2.80852758
45Sensory axonal neuropathy (HP:0003390)2.79081407
46Increased IgM level (HP:0003496)2.77065750
47* Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.76496029
48Seborrheic dermatitis (HP:0001051)2.76298376
49Hyporeflexia of lower limbs (HP:0002600)2.75412378
50Cortical dysplasia (HP:0002539)2.73324015
51Stomatitis (HP:0010280)2.72078438
52Truncus arteriosus (HP:0001660)2.69085830
53Abnormality of reticulocytes (HP:0004312)2.69061403
54Abnormality of DNA repair (HP:0003254)2.65471855
55Paralysis (HP:0003470)2.64433875
56Hypochromic microcytic anemia (HP:0004840)2.63748565
57Muscle fiber atrophy (HP:0100295)2.63455392
58Limb dystonia (HP:0002451)2.63104602
59IgG deficiency (HP:0004315)2.62974870
60Exotropia (HP:0000577)2.61610528
61Chromsome breakage (HP:0040012)2.60640112
62Abnormality of the foot musculature (HP:0001436)2.60508837
63Abnormality of T cells (HP:0002843)2.60441532
64Neuroblastic tumors (HP:0004376)2.55705716
65Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.55705716
66Neuroblastoma (HP:0003006)2.55705716
67Primitive neuroectodermal tumor (HP:0030065)2.55705716
683-Methylglutaconic aciduria (HP:0003535)2.54441077
69Abnormality of eosinophils (HP:0001879)2.53674225
70Fasciculations (HP:0002380)2.53284852
71Ileus (HP:0002595)2.52333527
72Horizontal nystagmus (HP:0000666)2.50588392
73Impaired proprioception (HP:0010831)2.50323416
74Aplastic anemia (HP:0001915)2.48916739
75Onion bulb formation (HP:0003383)2.47408941
76Hand muscle atrophy (HP:0009130)2.47306472
77Distal lower limb muscle weakness (HP:0009053)2.46007397
78Hypoventilation (HP:0002791)2.45622887
79Hypophosphatemic rickets (HP:0004912)2.42963276
80External ophthalmoplegia (HP:0000544)2.40191805
81Generalized hypotonia (HP:0001290)2.39002068
82Areflexia of lower limbs (HP:0002522)2.37654205
83Upper limb muscle weakness (HP:0003484)2.35978640
84Hypercortisolism (HP:0001578)2.34984535
85Difficulty running (HP:0009046)2.33847540
86Poikilocytosis (HP:0004447)2.32932202
87Eosinophilia (HP:0001880)2.32000158
88Abnormality of the musculature of the hand (HP:0001421)2.31284289
89Severe combined immunodeficiency (HP:0004430)2.31001400
90Multiple enchondromatosis (HP:0005701)2.29257016
91Cerebral palsy (HP:0100021)2.25503808
92Prolonged bleeding time (HP:0003010)2.24951008
93Cholelithiasis (HP:0001081)2.24883481
94Rapidly progressive (HP:0003678)2.23910619
95Dialeptic seizures (HP:0011146)2.22416200
96Muscle fibrillation (HP:0010546)2.20843705
97Hyperbilirubinemia (HP:0002904)2.20730234
98Increased connective tissue (HP:0009025)2.20118728
99Resting tremor (HP:0002322)2.19607748
100Decreased motor nerve conduction velocity (HP:0003431)2.19291673
101Horseshoe kidney (HP:0000085)2.18036525
102Curly hair (HP:0002212)2.17779480
103Abnormality of the vocal cords (HP:0008777)2.16759521
104Aplasia/Hypoplasia of the uvula (HP:0010293)2.16417149
105Apathy (HP:0000741)2.16298707
106Generalized tonic-clonic seizures (HP:0002069)2.15687375
107Recurrent viral infections (HP:0004429)2.13672830
108Acute encephalopathy (HP:0006846)2.12484446
109Amyotrophic lateral sclerosis (HP:0007354)2.12053901
110Ragged-red muscle fibers (HP:0003200)2.09086713
111Impulsivity (HP:0100710)2.08433369
112Abnormal number of erythroid precursors (HP:0012131)2.08403698
113* Dysautonomia (HP:0002459)2.08020773
114Limb hypertonia (HP:0002509)2.07544759
115Partial agenesis of the corpus callosum (HP:0001338)2.07312858
116Leukocytosis (HP:0001974)2.07248026
117Spastic gait (HP:0002064)2.06224601
118Duplicated collecting system (HP:0000081)2.05829761
119Homocystinuria (HP:0002156)2.04486434
120Abnormality of homocysteine metabolism (HP:0010919)2.04486434
121Distal upper limb amyotrophy (HP:0007149)2.04289769
122Upper limb amyotrophy (HP:0009129)2.04289769
123Morphological abnormality of the pyramidal tract (HP:0002062)2.02191331
124Postural tremor (HP:0002174)1.99631439
125Patellar aplasia (HP:0006443)1.99455740
126Malignant neoplasm of the central nervous system (HP:0100836)1.98876804
127Aplasia/Hypoplasia of the brainstem (HP:0007362)1.98846170
128Hypoplasia of the brainstem (HP:0002365)1.98846170
129Abnormality of the renal collecting system (HP:0004742)1.96483447
130Abnormal gallbladder morphology (HP:0012437)1.96237820
131Progressive cerebellar ataxia (HP:0002073)1.95973931
132Hypoproteinemia (HP:0003075)1.95070097
133Focal motor seizures (HP:0011153)1.94755699
134Lower limb muscle weakness (HP:0007340)1.93473722
135Optic nerve coloboma (HP:0000588)1.93181026
136Abnormality of calcium-phosphate metabolism (HP:0100530)1.93093744
137Myelodysplasia (HP:0002863)1.92973557
138Abnormal delayed hypersensitivity skin test (HP:0002963)1.91531227
139Nervous tissue neoplasm (HP:0030060)1.91199908
140Neuroectodermal neoplasm (HP:0030061)1.91199908
141Neuroepithelial neoplasm (HP:0030063)1.91199908
142Delusions (HP:0000746)1.91168395
143Hypokinesia (HP:0002375)1.91062649
144Renal Fanconi syndrome (HP:0001994)1.90835431
145Dyschromatopsia (HP:0007641)1.90550643
146Increased CSF protein (HP:0002922)1.90293124
147Diminished motivation (HP:0000745)1.89921041
148Abnormality of T cell physiology (HP:0011840)1.89476872
149Abnormality of oral frenula (HP:0000190)1.89090656
150Absence seizures (HP:0002121)1.88983629
151Tetraplegia (HP:0002445)1.88811983
152CNS hypomyelination (HP:0003429)1.88751093
153Depression (HP:0000716)1.87870066
154Abnormal mitochondria in muscle tissue (HP:0008316)1.87586351
155Chronic diarrhea (HP:0002028)1.87214199
156Neoplasm of the heart (HP:0100544)1.87053238
157Peripheral hypomyelination (HP:0007182)1.86378021
158Urinary urgency (HP:0000012)1.86056884
159Neonatal onset (HP:0003623)1.85177830
160Type I transferrin isoform profile (HP:0003642)1.83868355
161Increased serum pyruvate (HP:0003542)1.83777942
162Abnormality of glycolysis (HP:0004366)1.83777942
163Increased intramyocellular lipid droplets (HP:0012240)1.83492339
164Hyperthyroidism (HP:0000836)1.83418641
165Impaired platelet aggregation (HP:0003540)1.82425556
166Abnormal platelet function (HP:0011869)1.82425556
167Carpal bone hypoplasia (HP:0001498)1.82191457
168Combined immunodeficiency (HP:0005387)1.82042777
169Degeneration of anterior horn cells (HP:0002398)1.81242936
170Abnormality of the anterior horn cell (HP:0006802)1.81242936
171Molar tooth sign on MRI (HP:0002419)1.81033294
172Abnormality of midbrain morphology (HP:0002418)1.81033294
173Petechiae (HP:0000967)1.80967665
174Abnormality of the prostate (HP:0008775)1.80171934
175Aplasia/Hypoplasia of the patella (HP:0006498)1.79992737
176Poor suck (HP:0002033)1.79747356
177Recurrent fungal infections (HP:0002841)1.79645303
178Sandal gap (HP:0001852)1.79555597
179Cutis marmorata (HP:0000965)1.77636191
180Abnormality of the preputium (HP:0100587)1.77442215
181Panhypogammaglobulinemia (HP:0003139)1.77283188
182Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76388031
183Abnormal protein N-linked glycosylation (HP:0012347)1.76388031
184Abnormal protein glycosylation (HP:0012346)1.76388031
185Abnormal glycosylation (HP:0012345)1.76388031
186Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75039187
187Acute necrotizing encephalopathy (HP:0006965)1.73607092
188Autoimmune hemolytic anemia (HP:0001890)1.71892820
189Abnormality of the labia minora (HP:0012880)1.71652908
190Rib fusion (HP:0000902)1.70519716
191Pallor (HP:0000980)1.69914782
192Anomalous pulmonary venous return (HP:0010772)1.68754857
193Polymicrogyria (HP:0002126)1.66972929
194Joint swelling (HP:0001386)1.66924752
195Abnormality of sulfur amino acid metabolism (HP:0004339)1.66826857
196Enlarged kidneys (HP:0000105)1.66131825
197Clubbing of toes (HP:0100760)1.65537108
198Increased muscle lipid content (HP:0009058)1.63999895

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK55.52703742
2SRPK13.67023730
3GRK73.51641529
4INSRR3.12941808
5KSR23.06831161
6ADRBK23.01558040
7CDK122.98878145
8NTRK32.87370693
9MINK12.79249267
10ZAK2.69108766
11LMTK22.61154076
12TXK2.60627179
13GRK62.53195839
14MAP3K92.49977889
15FES2.44788249
16LATS22.34557801
17MAP3K22.31492619
18LIMK12.27917175
19PLK42.18076692
20MAPKAPK32.17085520
21MAP2K42.16923612
22TLK12.15330695
23WNK12.09225507
24ADRBK12.00229035
25TAOK31.97909547
26BTK1.96457886
27NME11.96191068
28SCYL21.95340475
29MAP3K111.81148610
30ICK1.77265619
31MAP4K21.76578023
32ARAF1.76561958
33ERN11.72904256
34MAP2K11.64541992
35ITK1.59264942
36NUAK11.51930650
37* NTRK11.50367930
38RET1.49656882
39MAP3K41.49274019
40BCR1.44795435
41EIF2AK11.41071466
42TEC1.39513673
43PHKG21.36887599
44PHKG11.36887599
45ATR1.33183700
46PKN11.31827350
47TAOK11.30452685
48BMPR21.29661316
49PRKG21.28951750
50TYRO31.28926683
51GRK11.27606921
52PINK11.27019333
53EPHA31.22995060
54RIPK41.22731627
55PRKCQ1.22360750
56LCK1.17338954
57MAP2K31.17254049
58MST41.16566197
59SYK1.12934194
60MOS1.11525692
61IKBKB1.07831398
62DYRK21.07790666
63PAK61.04956458
64PRKCG1.04874294
65MAP3K121.03788801
66TAOK21.03666631
67CLK11.01948338
68CDC71.00586749
69MAP3K70.98897376
70MARK10.98481874
71MAP3K140.96915815
72HIPK20.96597349
73MAPK130.96367581
74RPS6KA20.96130941
75BCKDK0.93732703
76PLK20.92519659
77CHEK20.91379224
78CSF1R0.90220532
79PDK20.89834344
80CDK140.88975529
81PIM10.88521463
82MARK20.86731620
83SGK2230.86119514
84SGK4940.86119514
85TRIM280.85435429
86FER0.85306634
87JAK30.85243741
88UHMK10.84153220
89CAMK40.81556081
90WNK40.81385855
91DAPK20.80484953
92WNK30.80041684
93MAP2K20.79196976
94MAP2K60.78695245
95CDK50.77342797
96TTK0.77199881
97MAP4K10.77010484
98FGFR30.76605891
99NEK10.76549884
100MAP2K70.76513751
101NLK0.76479246
102CSNK1A1L0.75889009
103MAP3K10.73678675
104TSSK60.72517675
105LYN0.72191586
106JAK20.71379621
107PTK20.69351015
108ATM0.69237938
109PRKCE0.68696819
110BMX0.68679562
111MARK30.68059073
112CSNK1G20.66928941
113MAPK70.66060556
114EIF2AK30.65929561
115CDK180.64484317
116CSNK1G30.64319055
117SIK30.64260173
118TGFBR20.62494964
119CDK150.62219822
120KDR0.61848510
121ILK0.60198073
122CAMKK20.59814346
123PAK10.59249946
124RAF10.58672182
125RPS6KA50.55454677
126MAP3K60.55382465
127IRAK10.54998776
128CDK40.54772459
129CDK80.54346204
130AKT30.53086126
131TESK10.52268777
132PDK30.52190091
133PDK40.52190091
134CSNK1E0.51942594
135WEE10.51880399
136CDK11A0.51701207
137PAK30.50480638
138HCK0.50047223
139ZAP700.49568590
140VRK10.48981031
141BRSK20.48591951
142BRD40.48180670
143MAPK30.47260751
144MAPK40.46960900
145CAMKK10.45615697
146PRKACG0.44329297
147AURKA0.44167091
148CDK20.44148152
149MAPK90.44103781
150EEF2K0.42985506
151PRKACA0.42465252
152TIE10.41704361
153CDK10.41104821
154ALK0.40784622
155PRKACB0.40174528
156MAPK110.40121525
157SGK20.39507486
158NEK60.39334661
159PRKCB0.39015243
160MAP3K80.38404533
161NEK20.38339010
162CASK0.38141358
163CSNK1G10.37983962
164PDGFRA0.37549686
165FLT30.35976239
166MAPK100.35709501
167PRKCD0.31934439
168DAPK10.30070368
169MAPK120.29498473
170* SRC0.29342133
171MAPK80.28821021
172RIPK10.25915292
173NTRK20.25871214
174YES10.25853575
175CAMK2G0.24850090
176PRKCI0.24571636
177BRAF0.24531072
178MAPKAPK50.24264634
179PDK10.23579101
180TESK20.23353894

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.63703102
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.16269603
3Synaptic vesicle cycle_Homo sapiens_hsa047213.15709151
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.08973924
5Primary immunodeficiency_Homo sapiens_hsa053403.06064232
6Non-homologous end-joining_Homo sapiens_hsa034502.86231640
7One carbon pool by folate_Homo sapiens_hsa006702.78174220
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.74036742
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.72065079
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64509952
11Spliceosome_Homo sapiens_hsa030402.34848967
12Dopaminergic synapse_Homo sapiens_hsa047282.06099857
13Nicotine addiction_Homo sapiens_hsa050332.05371759
14Tyrosine metabolism_Homo sapiens_hsa003502.03582345
15* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.02728788
16RNA polymerase_Homo sapiens_hsa030202.01461915
17Cholinergic synapse_Homo sapiens_hsa047251.96393722
18mRNA surveillance pathway_Homo sapiens_hsa030151.95450673
19RNA transport_Homo sapiens_hsa030131.93572979
20Fanconi anemia pathway_Homo sapiens_hsa034601.92965530
21Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.87964102
22Serotonergic synapse_Homo sapiens_hsa047261.84487211
23T cell receptor signaling pathway_Homo sapiens_hsa046601.84055199
24DNA replication_Homo sapiens_hsa030301.76855581
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76283960
26Homologous recombination_Homo sapiens_hsa034401.70967922
27Vitamin B6 metabolism_Homo sapiens_hsa007501.70014873
28Taste transduction_Homo sapiens_hsa047421.68811325
29Olfactory transduction_Homo sapiens_hsa047401.68475896
30Mismatch repair_Homo sapiens_hsa034301.67290841
31Dorso-ventral axis formation_Homo sapiens_hsa043201.60153114
32Insulin secretion_Homo sapiens_hsa049111.58971291
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58904599
34GnRH signaling pathway_Homo sapiens_hsa049121.57824683
35Basal transcription factors_Homo sapiens_hsa030221.54058512
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.53058963
37Phenylalanine metabolism_Homo sapiens_hsa003601.51325417
38Fructose and mannose metabolism_Homo sapiens_hsa000511.47810649
39Long-term potentiation_Homo sapiens_hsa047201.47479395
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47433367
41Gap junction_Homo sapiens_hsa045401.41130932
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40644961
43Long-term depression_Homo sapiens_hsa047301.40351750
44Alcoholism_Homo sapiens_hsa050341.40074785
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35203551
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32801598
47Measles_Homo sapiens_hsa051621.30996248
48Protein export_Homo sapiens_hsa030601.30626281
49Acute myeloid leukemia_Homo sapiens_hsa052211.29866572
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.28790763
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28684495
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27595699
53Amphetamine addiction_Homo sapiens_hsa050311.27549169
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25185196
55Phospholipase D signaling pathway_Homo sapiens_hsa040721.24295036
56Hematopoietic cell lineage_Homo sapiens_hsa046401.23705272
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21943481
58Cell cycle_Homo sapiens_hsa041101.21503373
59VEGF signaling pathway_Homo sapiens_hsa043701.21413349
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.21386130
61RNA degradation_Homo sapiens_hsa030181.21335603
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20484071
63Nucleotide excision repair_Homo sapiens_hsa034201.19732288
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19586288
65* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.19552591
66Bile secretion_Homo sapiens_hsa049761.19040140
67Collecting duct acid secretion_Homo sapiens_hsa049661.18462365
68Cocaine addiction_Homo sapiens_hsa050301.15890661
69Glutamatergic synapse_Homo sapiens_hsa047241.15439318
70Sulfur metabolism_Homo sapiens_hsa009201.13209755
71* Neurotrophin signaling pathway_Homo sapiens_hsa047221.12482940
72Renin secretion_Homo sapiens_hsa049241.12236071
73Vascular smooth muscle contraction_Homo sapiens_hsa042701.11964325
74Circadian entrainment_Homo sapiens_hsa047131.09741531
75Salivary secretion_Homo sapiens_hsa049701.08027726
76Pyrimidine metabolism_Homo sapiens_hsa002401.02546394
77Estrogen signaling pathway_Homo sapiens_hsa049151.01717576
78Purine metabolism_Homo sapiens_hsa002301.00208580
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.99461765
80Glioma_Homo sapiens_hsa052140.98108728
81* Thyroid cancer_Homo sapiens_hsa052160.97845049
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97687114
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97395346
84mTOR signaling pathway_Homo sapiens_hsa041500.97281762
85Regulation of autophagy_Homo sapiens_hsa041400.96255255
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96095147
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95715453
88Viral carcinogenesis_Homo sapiens_hsa052030.94968770
89Tryptophan metabolism_Homo sapiens_hsa003800.94929914
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93625165
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92373473
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.89174135
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88663890
94Choline metabolism in cancer_Homo sapiens_hsa052310.87998499
95Autoimmune thyroid disease_Homo sapiens_hsa053200.86543141
96N-Glycan biosynthesis_Homo sapiens_hsa005100.85828829
97Insulin signaling pathway_Homo sapiens_hsa049100.85635536
98Glycerolipid metabolism_Homo sapiens_hsa005610.82949573
99Oocyte meiosis_Homo sapiens_hsa041140.82798007
100Systemic lupus erythematosus_Homo sapiens_hsa053220.82635324
101Allograft rejection_Homo sapiens_hsa053300.82247431
102Vibrio cholerae infection_Homo sapiens_hsa051100.81884691
103GABAergic synapse_Homo sapiens_hsa047270.81140316
104Oxytocin signaling pathway_Homo sapiens_hsa049210.80991087
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79770935
106Calcium signaling pathway_Homo sapiens_hsa040200.79538935
107Parkinsons disease_Homo sapiens_hsa050120.79054358
108Nitrogen metabolism_Homo sapiens_hsa009100.78659193
109Gastric acid secretion_Homo sapiens_hsa049710.77272313
110Rap1 signaling pathway_Homo sapiens_hsa040150.75993157
111ErbB signaling pathway_Homo sapiens_hsa040120.75828182
112Fatty acid metabolism_Homo sapiens_hsa012120.74939385
113Melanogenesis_Homo sapiens_hsa049160.74828162
114Cardiac muscle contraction_Homo sapiens_hsa042600.73725918
115Asthma_Homo sapiens_hsa053100.73721490
116Axon guidance_Homo sapiens_hsa043600.72917653
117Graft-versus-host disease_Homo sapiens_hsa053320.72464881
118Prolactin signaling pathway_Homo sapiens_hsa049170.72044709
119Galactose metabolism_Homo sapiens_hsa000520.70904616
120Prion diseases_Homo sapiens_hsa050200.70659545
121Phototransduction_Homo sapiens_hsa047440.70113710
122Endometrial cancer_Homo sapiens_hsa052130.70108309
123* Central carbon metabolism in cancer_Homo sapiens_hsa052300.69164218
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68514273
125Histidine metabolism_Homo sapiens_hsa003400.68256331
126African trypanosomiasis_Homo sapiens_hsa051430.68020282
127Steroid biosynthesis_Homo sapiens_hsa001000.67835344
128Chemokine signaling pathway_Homo sapiens_hsa040620.66069696
129Epstein-Barr virus infection_Homo sapiens_hsa051690.65459576
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.65009508
131Base excision repair_Homo sapiens_hsa034100.63012261
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61765551
133Shigellosis_Homo sapiens_hsa051310.60602815
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60462569
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60191588
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58890569
137* Apoptosis_Homo sapiens_hsa042100.58520669
138Phagosome_Homo sapiens_hsa041450.58418944
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58409900
140Alzheimers disease_Homo sapiens_hsa050100.58392040
141Herpes simplex infection_Homo sapiens_hsa051680.58379568
142Oxidative phosphorylation_Homo sapiens_hsa001900.57897442
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57890164
144Biosynthesis of amino acids_Homo sapiens_hsa012300.56546901
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55469863
146Melanoma_Homo sapiens_hsa052180.55214030
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54877402
148Cyanoamino acid metabolism_Homo sapiens_hsa004600.54330787
149Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53464612
150Pancreatic secretion_Homo sapiens_hsa049720.53154574
151Proteasome_Homo sapiens_hsa030500.52966046
152Ras signaling pathway_Homo sapiens_hsa040140.51788381
153cAMP signaling pathway_Homo sapiens_hsa040240.51088849
154Thyroid hormone synthesis_Homo sapiens_hsa049180.50926732
155Ribosome_Homo sapiens_hsa030100.50474654
156Selenocompound metabolism_Homo sapiens_hsa004500.50275190
157Inositol phosphate metabolism_Homo sapiens_hsa005620.50061845
158Huntingtons disease_Homo sapiens_hsa050160.48932096
159Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48899351
160cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47903286
161Non-small cell lung cancer_Homo sapiens_hsa052230.46983139
162Glucagon signaling pathway_Homo sapiens_hsa049220.44496210
163Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43967190
164Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43803361
165alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43590305
166Chronic myeloid leukemia_Homo sapiens_hsa052200.43363044
167Morphine addiction_Homo sapiens_hsa050320.43204221
168Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42670211
169Butanoate metabolism_Homo sapiens_hsa006500.42484154
170Linoleic acid metabolism_Homo sapiens_hsa005910.42477956
171Salmonella infection_Homo sapiens_hsa051320.42208845
172Type II diabetes mellitus_Homo sapiens_hsa049300.41604878
173Ovarian steroidogenesis_Homo sapiens_hsa049130.40792014
174B cell receptor signaling pathway_Homo sapiens_hsa046620.40119763
175Platelet activation_Homo sapiens_hsa046110.37544494
176Hepatitis B_Homo sapiens_hsa051610.35166555
177TNF signaling pathway_Homo sapiens_hsa046680.32018253

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