NTSR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)6.76492336
2alanine transport (GO:0032328)6.43687338
3negative regulation of astrocyte differentiation (GO:0048712)6.24599693
4L-amino acid import (GO:0043092)5.99548681
5C4-dicarboxylate transport (GO:0015740)5.94928936
6cellular potassium ion homeostasis (GO:0030007)5.74435982
7amino acid import (GO:0043090)5.72714080
8regulation of synaptic vesicle exocytosis (GO:2000300)5.60735301
9cellular response to cholesterol (GO:0071397)5.52193354
10positive regulation of cellular amide metabolic process (GO:0034250)5.50431863
11sodium ion export (GO:0071436)5.42232445
12negative regulation of amyloid precursor protein catabolic process (GO:1902992)5.21066899
13L-serine transport (GO:0015825)4.99986990
14glial cell proliferation (GO:0014009)4.95361099
15low-density lipoprotein particle remodeling (GO:0034374)4.87960518
16parturition (GO:0007567)4.83549251
17regulation of synaptic vesicle transport (GO:1902803)4.80806771
18cell communication by electrical coupling (GO:0010644)4.71685961
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.71533662
20postsynaptic membrane organization (GO:0001941)4.66979100
21regulation of beta-amyloid formation (GO:1902003)4.65163545
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.61735280
23cellular response to sterol (GO:0036315)4.59002076
24neurotransmitter secretion (GO:0007269)4.54907957
25gamma-aminobutyric acid transport (GO:0015812)4.46400092
26regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.40299830
27regulation of neuronal synaptic plasticity (GO:0048168)4.38818140
28chondroitin sulfate catabolic process (GO:0030207)4.36365653
29serine transport (GO:0032329)4.34945233
30neurotransmitter-gated ion channel clustering (GO:0072578)4.31399430
31cellular sodium ion homeostasis (GO:0006883)4.22626754
32response to auditory stimulus (GO:0010996)4.22206638
33central nervous system myelination (GO:0022010)4.16083144
34axon ensheathment in central nervous system (GO:0032291)4.16083144
35exploration behavior (GO:0035640)4.15443536
36regulation of glutamate receptor signaling pathway (GO:1900449)4.13985986
37potassium ion import (GO:0010107)4.12245272
38regulation of phospholipid biosynthetic process (GO:0071071)4.09018248
39positive regulation of triglyceride biosynthetic process (GO:0010867)4.06311414
40positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.04484364
41regulation of astrocyte differentiation (GO:0048710)4.00328335
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.97094495
43neurotransmitter transport (GO:0006836)3.96947343
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.96277302
45regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.96193033
46locomotory exploration behavior (GO:0035641)3.95700050
47vocalization behavior (GO:0071625)3.95696768
48negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.94331714
49neurotransmitter uptake (GO:0001504)3.93832483
50dermatan sulfate metabolic process (GO:0030205)3.87066569
51cerebellar granule cell differentiation (GO:0021707)3.85942144
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.80154340
53dermatan sulfate biosynthetic process (GO:0030208)3.78896510
54regulation of amyloid precursor protein catabolic process (GO:1902991)3.78087380
55G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.73707245
56atrial cardiac muscle cell action potential (GO:0086014)3.70423496
57positive regulation of synapse maturation (GO:0090129)3.68860183
58regulation of ARF protein signal transduction (GO:0032012)3.68067010
59negative regulation of glial cell differentiation (GO:0045686)3.65740907
60positive regulation of dendritic spine development (GO:0060999)3.65732260
61neuron cell-cell adhesion (GO:0007158)3.65568858
62synaptic transmission, glutamatergic (GO:0035249)3.62780554
63potassium ion homeostasis (GO:0055075)3.60441241
64blood vessel maturation (GO:0001955)3.58282724
65regulation of neurotransmitter secretion (GO:0046928)3.57740546
66acidic amino acid transport (GO:0015800)3.56504168
67neuronal ion channel clustering (GO:0045161)3.56335637
68neuromuscular process controlling balance (GO:0050885)3.56305730
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.55691909
70ovulation cycle (GO:0042698)3.53731901
71negative regulation of response to reactive oxygen species (GO:1901032)3.49956798
72regulation of neurotransmitter levels (GO:0001505)3.47923083
73regulation of synaptic plasticity (GO:0048167)3.46924800
74neuronal action potential propagation (GO:0019227)3.46696644
75regulation of hydrogen peroxide-induced cell death (GO:1903205)3.46273939
76positive regulation of potassium ion transmembrane transport (GO:1901381)3.44774010
77negative regulation of smoothened signaling pathway (GO:0045879)3.42446054
78auditory behavior (GO:0031223)3.41786430
79regulation of neurotransmitter transport (GO:0051588)3.41739750
80cellular response to reactive nitrogen species (GO:1902170)3.39095460
81negative regulation of sodium ion transport (GO:0010766)3.37977915
82regulation of synapse structural plasticity (GO:0051823)3.33993370
83positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.32733204
84synaptic vesicle endocytosis (GO:0048488)3.32433140
85peripheral nervous system axon ensheathment (GO:0032292)3.31808772
86myelination in peripheral nervous system (GO:0022011)3.31808772
87regulation of excitatory postsynaptic membrane potential (GO:0060079)3.31318838
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28754208
89regulation of voltage-gated calcium channel activity (GO:1901385)3.26610348
90response to cholesterol (GO:0070723)3.25697518
91regulation of steroid hormone biosynthetic process (GO:0090030)3.25336264
92positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.25203971
93positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.22735031
94protein localization to synapse (GO:0035418)3.21389024
95regulation of cellular amide metabolic process (GO:0034248)3.19625283
96regulation of axon regeneration (GO:0048679)3.19316536
97regulation of neuron projection regeneration (GO:0070570)3.19316536
98proline transport (GO:0015824)3.16398531
99neuron-neuron synaptic transmission (GO:0007270)3.15776338
100transmission of nerve impulse (GO:0019226)3.15254538
101lens fiber cell development (GO:0070307)3.12958079
102negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12570016
103triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.12287265
104long-term synaptic potentiation (GO:0060291)3.12088149
105regulation of female receptivity (GO:0045924)3.11251291
106presynaptic membrane organization (GO:0097090)3.10540325
107positive regulation of membrane potential (GO:0045838)3.10131007
108gamma-aminobutyric acid signaling pathway (GO:0007214)3.09198967
109glutamate receptor signaling pathway (GO:0007215)3.07626814
110astrocyte development (GO:0014002)3.07543605
111regulation of dendritic spine development (GO:0060998)3.06954235
112cerebellar Purkinje cell differentiation (GO:0021702)3.05921034
113L-glutamate transport (GO:0015813)3.05630250
114daunorubicin metabolic process (GO:0044597)3.04662122
115polyketide metabolic process (GO:0030638)3.04662122
116doxorubicin metabolic process (GO:0044598)3.04662122
117regulation of postsynaptic membrane potential (GO:0060078)3.04216421
118presynaptic membrane assembly (GO:0097105)3.04114049
119reverse cholesterol transport (GO:0043691)3.00568541
120response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.00021203
121adenine nucleotide transport (GO:0051503)2.99971357
122regulation of synapse maturation (GO:0090128)2.99553415
123regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.99156132
124response to histamine (GO:0034776)2.98450609
125membrane repolarization (GO:0086009)2.98225866
126neuroblast proliferation (GO:0007405)2.97690549
127layer formation in cerebral cortex (GO:0021819)2.97671649
128response to methylmercury (GO:0051597)2.96873037
129regulation of membrane repolarization (GO:0060306)2.96057438
130regulation of triglyceride biosynthetic process (GO:0010866)2.95702472
131regulation of dendritic spine morphogenesis (GO:0061001)2.91263382
132negative regulation of dendrite morphogenesis (GO:0050774)2.90760975
133response to sterol (GO:0036314)2.90411739
134dendritic spine morphogenesis (GO:0060997)2.90331402
135long-term memory (GO:0007616)2.89089908
136activation of protein kinase A activity (GO:0034199)2.88713871
137alpha-linolenic acid metabolic process (GO:0036109)2.88193479
138ionotropic glutamate receptor signaling pathway (GO:0035235)2.87758992
139linoleic acid metabolic process (GO:0043651)2.87512517
140oligodendrocyte differentiation (GO:0048709)2.86186198
141response to gravity (GO:0009629)2.85836298
142positive regulation of alcohol biosynthetic process (GO:1902932)2.84152625
143sterol catabolic process (GO:0016127)2.83790338
144cholesterol catabolic process (GO:0006707)2.83790338
145heart trabecula morphogenesis (GO:0061384)2.82365847
146regulation of synaptic transmission (GO:0050804)2.81637859
147cerebral cortex neuron differentiation (GO:0021895)2.81239108
148synaptic vesicle exocytosis (GO:0016079)2.80442450
149cGMP-mediated signaling (GO:0019934)2.79204563
150synaptic vesicle maturation (GO:0016188)2.76895971
151regulation of short-term neuronal synaptic plasticity (GO:0048172)2.76245139
152regulation of cholesterol biosynthetic process (GO:0045540)2.75154401
153regulation of inositol phosphate biosynthetic process (GO:0010919)2.74684495
154regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73750740
155glutamate secretion (GO:0014047)2.73366433
156response to dietary excess (GO:0002021)2.72096690
157positive regulation of neurotransmitter transport (GO:0051590)2.71915361
158regulation of cholesterol esterification (GO:0010872)2.71386274
159glycogen catabolic process (GO:0005980)2.71067445
160regulation of response to osmotic stress (GO:0047484)2.70667768
161negative regulation of inclusion body assembly (GO:0090084)2.70374779
162L-serine metabolic process (GO:0006563)2.69254518
163regulation of synaptic transmission, glutamatergic (GO:0051966)2.69101984
164cerebellar Purkinje cell layer development (GO:0021680)2.68763401
165negative regulation of stress fiber assembly (GO:0051497)2.67407519

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.85626807
2* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10226609
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92875405
4* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.91665861
5AR_21572438_ChIP-Seq_LNCaP_Human2.85919190
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.80557610
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66241107
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58103245
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58103245
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56060630
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54270092
12GBX2_23144817_ChIP-Seq_PC3_Human2.53702798
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50542284
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44646200
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.38059210
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32536803
17* RNF2_27304074_Chip-Seq_ESCs_Mouse2.26375086
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.18903785
19DROSHA_22980978_ChIP-Seq_HELA_Human2.17885829
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.16781812
21* REST_21632747_ChIP-Seq_MESCs_Mouse2.11696725
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.99467836
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96458551
24* EZH2_27294783_Chip-Seq_ESCs_Mouse1.89590030
25RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.80944593
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76271976
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70730029
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63952694
29* RARB_27405468_Chip-Seq_BRAIN_Mouse1.60914423
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59284959
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57652900
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.53900014
33* REST_18959480_ChIP-ChIP_MESCs_Mouse1.53647977
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.53175391
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52663243
36RXR_22108803_ChIP-Seq_LS180_Human1.51490380
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50695916
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.50493436
39KDM2B_26808549_Chip-Seq_K562_Human1.44137782
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.43830436
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42894917
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41291131
43TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.34739439
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34010723
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30135761
46AR_25329375_ChIP-Seq_VCAP_Human1.28593887
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.27961777
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27664464
49TP53_16413492_ChIP-PET_HCT116_Human1.26697214
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.25976328
51TAF15_26573619_Chip-Seq_HEK293_Human1.25589964
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24875997
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24496630
54BCAT_22108803_ChIP-Seq_LS180_Human1.24176564
55GATA1_22025678_ChIP-Seq_K562_Human1.23010360
56P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19694741
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19687820
58P300_19829295_ChIP-Seq_ESCs_Human1.19615171
59SMAD4_21799915_ChIP-Seq_A2780_Human1.19335449
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18522251
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18399345
62TP53_20018659_ChIP-ChIP_R1E_Mouse1.18111842
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17458702
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16632003
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15671729
66AR_19668381_ChIP-Seq_PC3_Human1.14133004
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13788999
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11500483
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10776270
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10307542
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.09739309
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09352709
73CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09133481
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08956530
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.08255835
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.07732350
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04874672
78* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03121341
79* TP53_18474530_ChIP-ChIP_U2OS_Human1.03082441
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02355693
81CTCF_27219007_Chip-Seq_Bcells_Human1.01293574
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00444446
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99981878
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99851479
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99563124
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99518826
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97914344
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96261179
89ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95748698
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94923284
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94542055
92* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93871830
93RING1B_27294783_Chip-Seq_NPCs_Mouse0.93034556
94ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92835562
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92645864
96SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92350259
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92300667
98STAT3_23295773_ChIP-Seq_U87_Human0.90243866
99YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88079840
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.88034339
101RUNX2_22187159_ChIP-Seq_PCA_Human0.86743778
102EP300_21415370_ChIP-Seq_HL-1_Mouse0.86300598
103RUNX1_26923725_Chip-Seq_HPCs_Mouse0.86084204
104EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86019262
105* TCF4_23295773_ChIP-Seq_U87_Human0.86012297
106CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.85931937
107OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85880987
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.85132387
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85058960
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84788881
111HTT_18923047_ChIP-ChIP_STHdh_Human0.84379338
112TET1_21490601_ChIP-Seq_MESCs_Mouse0.83995565
113* SMAD3_21741376_ChIP-Seq_ESCs_Human0.83269113
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83030386
115TCF4_18268006_ChIP-ChIP_LS174T_Human0.83008271
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81957200
117ARNT_22903824_ChIP-Seq_MCF-7_Human0.81785823
118DPY_21335234_ChIP-Seq_ESCs_Mouse0.81463962
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81407580
120* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.81207765
121KLF4_19829295_ChIP-Seq_ESCs_Human0.80989222
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79911114
123ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.79657319
124MITF_21258399_ChIP-Seq_MELANOMA_Human0.79516445
125* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78907740
126EGR1_19032775_ChIP-ChIP_M12_Human0.78366913
127TBX3_20139965_ChIP-Seq_ESCs_Mouse0.77987411

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003690_abnormal_glial_cell3.90829964
2MP0002254_reproductive_system_inflammat3.88115689
3MP0003329_amyloid_beta_deposits3.64726750
4MP0004859_abnormal_synaptic_plasticity3.41299499
5MP0005646_abnormal_pituitary_gland3.23037951
6MP0002822_catalepsy3.22559027
7MP0004858_abnormal_nervous_system2.99919367
8MP0004885_abnormal_endolymph2.86913920
9MP0000566_synostosis2.49491134
10* MP0003635_abnormal_synaptic_transmissio2.46845220
11MP0001502_abnormal_circadian_rhythm2.45786850
12* MP0001486_abnormal_startle_reflex2.39532144
13MP0005423_abnormal_somatic_nervous2.36417996
14MP0004270_analgesia2.35890617
15MP0009840_abnormal_foam_cell2.32213199
16MP0009384_cardiac_valve_regurgitation2.24495495
17MP0002638_abnormal_pupillary_reflex2.24386035
18MP0009046_muscle_twitch2.21725686
19MP0003075_altered_response_to2.19029444
20MP0003879_abnormal_hair_cell2.12163537
21MP0002064_seizures2.11880361
22MP0009745_abnormal_behavioral_response2.10660392
23MP0003279_aneurysm2.10500869
24MP0000604_amyloidosis2.07764034
25MP0009780_abnormal_chondrocyte_physiolo2.06904432
26MP0002572_abnormal_emotion/affect_behav2.02705982
27MP0008569_lethality_at_weaning1.98435383
28MP0002063_abnormal_learning/memory/cond1.98370340
29MP0001440_abnormal_grooming_behavior1.96751296
30MP0001984_abnormal_olfaction1.92200133
31MP0003634_abnormal_glial_cell1.91909728
32MP0003878_abnormal_ear_physiology1.91167503
33MP0005377_hearing/vestibular/ear_phenot1.91167503
34MP0003011_delayed_dark_adaptation1.84250434
35MP0003880_abnormal_central_pattern1.71643003
36MP0003633_abnormal_nervous_system1.70912735
37MP0005645_abnormal_hypothalamus_physiol1.64035076
38MP0002734_abnormal_mechanical_nocicepti1.62101907
39MP0003136_yellow_coat_color1.61434903
40MP0001853_heart_inflammation1.58837914
41MP0002909_abnormal_adrenal_gland1.55125134
42MP0001501_abnormal_sleep_pattern1.51621698
43MP0002557_abnormal_social/conspecific_i1.50241318
44MP0003631_nervous_system_phenotype1.49585664
45MP0001485_abnormal_pinna_reflex1.49561470
46MP0004811_abnormal_neuron_physiology1.49096370
47MP0002272_abnormal_nervous_system1.45886006
48MP0003632_abnormal_nervous_system1.44636531
49MP0005187_abnormal_penis_morphology1.42131619
50MP0001968_abnormal_touch/_nociception1.39489834
51MP0005551_abnormal_eye_electrophysiolog1.37959166
52MP0002736_abnormal_nociception_after1.37148510
53MP0002090_abnormal_vision1.36635136
54MP0003137_abnormal_impulse_conducting1.35139401
55MP0002067_abnormal_sensory_capabilities1.32518791
56MP0005379_endocrine/exocrine_gland_phen1.30630291
57MP0006292_abnormal_olfactory_placode1.27583138
58MP0002127_abnormal_cardiovascular_syste1.25539386
59MP0001727_abnormal_embryo_implantation1.24629385
60MP0003183_abnormal_peptide_metabolism1.24177872
61MP0000778_abnormal_nervous_system1.23919353
62MP0005253_abnormal_eye_physiology1.20376507
63MP0004215_abnormal_myocardial_fiber1.19174858
64MP0005332_abnormal_amino_acid1.18523398
65MP0004142_abnormal_muscle_tone1.18449975
66MP0005167_abnormal_blood-brain_barrier1.14491969
67MP0002882_abnormal_neuron_morphology1.08422403
68* MP0002733_abnormal_thermal_nociception1.08239816
69MP0005386_behavior/neurological_phenoty1.07464797
70MP0004924_abnormal_behavior1.07464797
71MP0010030_abnormal_orbit_morphology1.06154962
72MP0000049_abnormal_middle_ear1.06123937
73MP0003787_abnormal_imprinting1.04248298
74MP0001905_abnormal_dopamine_level0.99109314
75MP0005171_absent_coat_pigmentation0.98814200
76MP0001299_abnormal_eye_distance/0.98739207
77MP0006276_abnormal_autonomic_nervous0.97860852
78MP0000955_abnormal_spinal_cord0.95020551
79MP0002089_abnormal_postnatal_growth/wei0.94443199
80MP0000920_abnormal_myelination0.94349569
81MP0005166_decreased_susceptibility_to0.94070402
82MP0002152_abnormal_brain_morphology0.93071420
83MP0001963_abnormal_hearing_physiology0.92937574
84* MP0001970_abnormal_pain_threshold0.90837254
85MP0008874_decreased_physiological_sensi0.90778333
86MP0005165_increased_susceptibility_to0.90256592
87MP0000751_myopathy0.90063209
88MP0003315_abnormal_perineum_morphology0.89166786
89* MP0002066_abnormal_motor_capabilities/c0.88943926
90MP0001986_abnormal_taste_sensitivity0.87246165
91MP0004742_abnormal_vestibular_system0.86976395
92MP0004043_abnormal_pH_regulation0.85130601
93MP0003172_abnormal_lysosome_physiology0.84778031
94MP0000647_abnormal_sebaceous_gland0.84380086
95MP0000026_abnormal_inner_ear0.84365886
96MP0005595_abnormal_vascular_smooth0.83756184
97MP0005647_abnormal_sex_gland0.83600054
98MP0005535_abnormal_body_temperature0.81917413
99MP0002229_neurodegeneration0.81631452
100MP0004130_abnormal_muscle_cell0.81578127
101MP0000631_abnormal_neuroendocrine_gland0.81324879
102MP0002249_abnormal_larynx_morphology0.79562093
103MP0006072_abnormal_retinal_apoptosis0.76673166
104MP0001529_abnormal_vocalization0.75447892
105MP0000639_abnormal_adrenal_gland0.74406480
106MP0005670_abnormal_white_adipose0.72509524
107MP0003646_muscle_fatigue0.72071240
108MP0002184_abnormal_innervation0.71930010
109MP0010329_abnormal_lipoprotein_level0.69618242
110MP0001177_atelectasis0.68860805
111MP0002752_abnormal_somatic_nervous0.65659728
112MP0010386_abnormal_urinary_bladder0.64926450
113MP0000428_abnormal_craniofacial_morphol0.62559710
114MP0002069_abnormal_eating/drinking_beha0.62329645
115MP0000681_abnormal_thyroid_gland0.62309548
116MP0003283_abnormal_digestive_organ0.62028009
117MP0004233_abnormal_muscle_weight0.61278761
118MP0002735_abnormal_chemical_nociception0.58101360
119MP0004085_abnormal_heartbeat0.52066848
120MP0004484_altered_response_of0.48706955
121MP0003956_abnormal_body_size0.47059392
122MP0000747_muscle_weakness0.44336544
123MP0003123_paternal_imprinting0.43994368
124MP0001346_abnormal_lacrimal_gland0.42376994
125MP0001943_abnormal_respiration0.40065008
126MP0003045_fibrosis0.40059311
127MP0002971_abnormal_brown_adipose0.40048872

Predicted human phenotypes

RankGene SetZ-score
1Megalencephaly (HP:0001355)7.92879411
2Aplasia involving bones of the upper limbs (HP:0009823)7.02126492
3Aplasia of the phalanges of the hand (HP:0009802)7.02126492
4Aplasia involving bones of the extremities (HP:0009825)7.02126492
5Neurofibrillary tangles (HP:0002185)5.55572317
6Ankle clonus (HP:0011448)4.61118536
7Abnormality of binocular vision (HP:0011514)4.50916265
8Diplopia (HP:0000651)4.50916265
9Bundle branch block (HP:0011710)4.41560688
10Hemiparesis (HP:0001269)4.37021001
11Abnormality of secondary sexual hair (HP:0009888)4.26999028
12Abnormality of the axillary hair (HP:0100134)4.26999028
13Febrile seizures (HP:0002373)4.20963497
14Cerebral inclusion bodies (HP:0100314)4.13378200
15Clumsiness (HP:0002312)4.04982396
16Enlarged penis (HP:0000040)4.03056526
17Atonic seizures (HP:0010819)3.91248507
18Hemiplegia (HP:0002301)3.90381514
19Back pain (HP:0003418)3.87452199
20Hypoplastic left heart (HP:0004383)3.82808799
21Visual hallucinations (HP:0002367)3.75569666
22Synostosis involving the elbow (HP:0003938)3.72247209
23Humeroradial synostosis (HP:0003041)3.72247209
24Gonadotropin excess (HP:0000837)3.54866752
25Spastic gait (HP:0002064)3.49058570
26Atrioventricular block (HP:0001678)3.47172469
27Neonatal hypoglycemia (HP:0001998)3.46277398
28Split foot (HP:0001839)3.43718145
29Impaired vibration sensation in the lower limbs (HP:0002166)3.41099200
30Peripheral hypomyelination (HP:0007182)3.37485115
31Asymmetric septal hypertrophy (HP:0001670)3.36752974
32Scanning speech (HP:0002168)3.35531833
33Intention tremor (HP:0002080)3.34821813
34Urinary bladder sphincter dysfunction (HP:0002839)3.27765129
35Dysmetria (HP:0001310)3.26471581
36Focal motor seizures (HP:0011153)3.23741841
37Urinary urgency (HP:0000012)3.23535294
38Increased circulating renin level (HP:0000848)3.23253469
39Hypokalemic alkalosis (HP:0001949)3.22215827
40Macroorchidism (HP:0000053)3.20843635
41Papilledema (HP:0001085)3.12807001
42Fibular aplasia (HP:0002990)3.06875883
43Abnormality of the middle phalanges of the toes (HP:0010183)3.06407695
44Obstructive sleep apnea (HP:0002870)3.05893760
45Absence seizures (HP:0002121)2.98430120
46Pseudobulbar signs (HP:0002200)2.96559663
47Adactyly (HP:0009776)2.95661747
48Epileptic encephalopathy (HP:0200134)2.94976894
49Dialeptic seizures (HP:0011146)2.92415955
50Heart block (HP:0012722)2.91172103
51Hypoplastic heart (HP:0001961)2.90971145
52Tetraplegia (HP:0002445)2.87624895
53Supranuclear gaze palsy (HP:0000605)2.78683475
54Mutism (HP:0002300)2.73095189
55Hyperglycinuria (HP:0003108)2.72796693
56Status epilepticus (HP:0002133)2.71162879
57Myokymia (HP:0002411)2.70296828
58Short hallux (HP:0010109)2.70222133
59Absent hair (HP:0002298)2.68928187
60Abnormal atrioventricular conduction (HP:0005150)2.65323303
61Neuronal loss in central nervous system (HP:0002529)2.63664287
62Lower limb muscle weakness (HP:0007340)2.62450659
63Clonus (HP:0002169)2.60685616
64Long nose (HP:0003189)2.60244268
65Mixed hearing impairment (HP:0000410)2.59571807
66Abnormality of the dental pulp (HP:0006479)2.59271909
67Annular pancreas (HP:0001734)2.57663680
68Torticollis (HP:0000473)2.53699325
69Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.50339196
70Degeneration of the lateral corticospinal tracts (HP:0002314)2.50339196
71Aplasia/Hypoplasia of the hallux (HP:0008362)2.49250977
72Anxiety (HP:0000739)2.45886484
73Delusions (HP:0000746)2.44547438
74Abnormality of the corticospinal tract (HP:0002492)2.43791313
75Confusion (HP:0001289)2.43322504
76Abnormality of serine family amino acid metabolism (HP:0010894)2.42718679
77Abnormality of glycine metabolism (HP:0010895)2.42718679
78Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.37393279
79Cerebral hypomyelination (HP:0006808)2.36168598
80Onycholysis (HP:0001806)2.34744713
81Impaired vibratory sensation (HP:0002495)2.34098617
82Akinesia (HP:0002304)2.34034442
83Limb dystonia (HP:0002451)2.32386296
84Broad alveolar ridges (HP:0000187)2.31611965
85Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.30153404
86Mesangial abnormality (HP:0001966)2.28141173
87Potter facies (HP:0002009)2.28074091
88Facial shape deformation (HP:0011334)2.28074091
89Symphalangism affecting the phalanges of the hand (HP:0009773)2.27965347
90Apathy (HP:0000741)2.27334460
91Hammertoe (HP:0001765)2.24225600
92Poor eye contact (HP:0000817)2.22788160
93Foot dorsiflexor weakness (HP:0009027)2.22449719
94Hypoalphalipoproteinemia (HP:0003233)2.22022137
95Hyperlipoproteinemia (HP:0010980)2.21710169
96Bradykinesia (HP:0002067)2.21678276
97Focal dystonia (HP:0004373)2.20933375
98Dysdiadochokinesis (HP:0002075)2.20534671
99Amyloidosis (HP:0011034)2.19938992
100Epileptiform EEG discharges (HP:0011182)2.17810724
101Tetraparesis (HP:0002273)2.15019751
102Impaired smooth pursuit (HP:0007772)2.12544056
103Spastic tetraparesis (HP:0001285)2.11763287
104Abnormal eating behavior (HP:0100738)2.11420935
105Narrow nasal bridge (HP:0000446)2.11192497
106Action tremor (HP:0002345)2.10237341
107Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.10163128
108Short middle phalanx of the 5th finger (HP:0004220)2.06384184
109Diminished motivation (HP:0000745)2.06193420
110Progressive neurologic deterioration (HP:0002344)2.05024492
111Neonatal short-limb short stature (HP:0008921)2.04956870
112Abnormal EKG (HP:0003115)2.04212855
113Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.03598887
114Dementia (HP:0000726)2.03062481
115Bronchomalacia (HP:0002780)2.02833822
116Truncal ataxia (HP:0002078)2.02506685
117Abnormality of permanent molar morphology (HP:0011071)2.01922629
118Abnormality of the dental root (HP:0006486)2.01922629
119Taurodontia (HP:0000679)2.01922629
120Abnormality of the foot musculature (HP:0001436)2.01123601
121Sleep apnea (HP:0010535)2.01058912
122Focal seizures (HP:0007359)2.00125893
123Abnormality of the periventricular white matter (HP:0002518)1.99725050
124Craniofacial dystonia (HP:0012179)1.98934066
125Hypoplastic pelvis (HP:0008839)1.98802139
126Stereotypic behavior (HP:0000733)1.98074714
127Metabolic alkalosis (HP:0200114)1.97321698
128Exercise-induced myalgia (HP:0003738)1.96337989
129Insomnia (HP:0100785)1.95162352
130Coronal craniosynostosis (HP:0004440)1.95028962
131Generalized tonic-clonic seizures (HP:0002069)1.94810012
132Polygenic inheritance (HP:0010982)1.94374603
133Abnormality of nail color (HP:0100643)1.93738117
134Progressive cerebellar ataxia (HP:0002073)1.93545717
135Choreoathetosis (HP:0001266)1.92077064
136Abnormality of molar (HP:0011077)1.91737033
137Abnormality of molar morphology (HP:0011070)1.91737033
138Abnormality of ocular smooth pursuit (HP:0000617)1.91707481
139Postural instability (HP:0002172)1.91658814
140Hyporeflexia of lower limbs (HP:0002600)1.90577118
141Maternal diabetes (HP:0009800)1.90080071
142Testicular neoplasm (HP:0010788)1.90079960
143Polyphagia (HP:0002591)1.89746307
144Autoamputation (HP:0001218)1.89171914
145Abnormality of the phalanges of the 5th finger (HP:0004213)1.88829991
146Rigidity (HP:0002063)1.88174605
147Ketoacidosis (HP:0001993)1.87118764
148EEG with generalized epileptiform discharges (HP:0011198)1.86404128
149Bradycardia (HP:0001662)1.86403558
150Abnormal social behavior (HP:0012433)1.85007848
151Impaired social interactions (HP:0000735)1.85007848
152Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84228874
153Multifactorial inheritance (HP:0001426)1.83915863
154Decreased motor nerve conduction velocity (HP:0003431)1.83322653
155Alacrima (HP:0000522)1.82781558
156Sensorimotor neuropathy (HP:0007141)1.81541981
157Absent toe (HP:0010760)1.80527268
158Athetosis (HP:0002305)1.79043283
159Abnormal urine output (HP:0012590)1.73684700
160Aplasia/Hypoplasia of the fibula (HP:0006492)1.73457412
161Paraparesis (HP:0002385)1.71578913
162Turricephaly (HP:0000262)1.71359062
163Median cleft lip (HP:0000161)1.70008400
164Abnormality of the phalanges of the 2nd finger (HP:0009541)1.69633550
165Cutaneous syndactyly (HP:0012725)1.68869009
166Depression (HP:0000716)1.67863279
167Abnormality of homocysteine metabolism (HP:0010919)1.64793338
168Homocystinuria (HP:0002156)1.64793338
169Oligodactyly (hands) (HP:0001180)1.62340826
170Limb ataxia (HP:0002070)1.61710206
171Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.60543328
172Abnormality of proline metabolism (HP:0010907)1.59720848
173Hydroxyprolinuria (HP:0003080)1.59720848

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.86696094
2LMTK25.59909090
3PHKG24.49895129
4PHKG14.49895129
5TNIK4.35504079
6NTRK23.37345628
7MUSK3.09507576
8UHMK12.90715923
9PRKD32.65966067
10PAK22.51005639
11SIK12.35992839
12NTRK32.20621728
13TRIB32.03164248
14CASK1.58728279
15MAPK121.52195374
16SGK21.49646025
17MAPK131.49215200
18MINK11.41559557
19SGK4941.36585484
20SGK2231.36585484
21PRPF4B1.30868616
22ARAF1.25497260
23PKN11.23172394
24SGK31.20181715
25FGR1.16886110
26EEF2K1.09893413
27PRKCG1.06984691
28MAP2K71.06265498
29PINK11.03092189
30MAP3K41.02240822
31LATS20.99044760
32MARK10.98737946
33FGFR20.97058205
34CDK50.96764536
35BMPR20.95121635
36MAP3K20.88671352
37IRAK30.88415041
38GRK60.86546220
39CAMK2D0.83716080
40ADRBK10.83157846
41PAK60.82929864
42NTRK10.82495822
43TYRO30.82248978
44TNK20.81811371
45DAPK10.81207705
46MAP3K90.79859593
47MAP3K130.79373320
48MAPKAPK50.77936025
49DYRK1A0.76442797
50ALK0.75851086
51DDR20.74179694
52STK380.73268016
53MAPK70.70550387
54INSRR0.70164638
55STK110.70101729
56CAMK2A0.69476328
57CAMKK10.66054499
58PRKCH0.65899956
59BMX0.65651896
60MAPKAPK30.65455293
61PRKCE0.64774350
62TAOK20.64523854
63CAMK40.62777012
64ROCK10.60850695
65TRPM70.59435337
66SGK10.57541339
67CDC42BPA0.57172529
68PAK30.56131437
69CDK30.56032753
70KSR20.54959483
71PDK10.53534558
72SIK20.53438107
73RIPK40.53003878
74CDK190.51421358
75PRKD20.50630997
76RIPK10.50387289
77FGFR10.48898885
78BRSK10.48540984
79MKNK20.48055578
80CAMK2G0.47916934
81DAPK20.46901437
82PRKCA0.46465653
83ROCK20.46443647
84DMPK0.44960903
85JAK10.44795078
86RPS6KA30.44396705
87CDK150.44370254
88RET0.43661872
89CAMK10.43555048
90RPS6KB10.42796719
91PRKACG0.42167037
92PRKD10.42162607
93PRKACA0.41824144
94MAP2K10.41812990
95FES0.41783944
96IGF1R0.41554267
97PRKCZ0.41380339
98CDK180.41366390
99SCYL20.41062903
100PRKCQ0.40301235
101CAMK1G0.39909469
102PRKAA20.39803893
103GRK50.39436472
104MAP3K70.37593542
105DAPK30.37293475
106MAPK40.37068900
107CDK11A0.36854962
108PRKG20.36487245
109MAP2K40.35349455
110CSNK1G20.33824912
111SRC0.33303881
112RAF10.33229415
113PRKG10.32866354
114CAMK1D0.32739269
115NEK60.32488301
116MAP3K110.32259967
117MARK20.31251795
118CDK140.31000998
119BCKDK0.30662057
120PDPK10.29848213
121FYN0.29611823
122FGFR30.28762451
123PRKAA10.28229254
124PDGFRA0.27232556
125MAPK100.27011143
126CAMK2B0.26947069
127AKT20.26087834
128PRKACB0.24879799
129ERBB40.24811726
130CAMKK20.24593154
131PLK20.23848738

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009106.62034018
2Fatty acid biosynthesis_Homo sapiens_hsa000615.25664189
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.62929137
4Fatty acid metabolism_Homo sapiens_hsa012122.73144410
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.39160000
6Nicotine addiction_Homo sapiens_hsa050332.33277756
7Fatty acid degradation_Homo sapiens_hsa000712.32224324
8Glutamatergic synapse_Homo sapiens_hsa047241.94879604
9GABAergic synapse_Homo sapiens_hsa047271.89072471
10Steroid biosynthesis_Homo sapiens_hsa001001.85479136
11Salivary secretion_Homo sapiens_hsa049701.76871136
12Insulin secretion_Homo sapiens_hsa049111.58750281
13Gastric acid secretion_Homo sapiens_hsa049711.52034008
14PPAR signaling pathway_Homo sapiens_hsa033201.48474178
15Circadian entrainment_Homo sapiens_hsa047131.41849324
16Cocaine addiction_Homo sapiens_hsa050301.38639776
17Bile secretion_Homo sapiens_hsa049761.35169059
18Morphine addiction_Homo sapiens_hsa050321.35053295
19Circadian rhythm_Homo sapiens_hsa047101.27974129
20Propanoate metabolism_Homo sapiens_hsa006401.27208093
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27029294
22Olfactory transduction_Homo sapiens_hsa047401.25751204
23Prolactin signaling pathway_Homo sapiens_hsa049171.24682321
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23420815
25Ovarian steroidogenesis_Homo sapiens_hsa049131.14865438
26Estrogen signaling pathway_Homo sapiens_hsa049151.13088371
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12931034
28Glioma_Homo sapiens_hsa052141.07267819
29Calcium signaling pathway_Homo sapiens_hsa040201.02391337
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01978054
31Long-term potentiation_Homo sapiens_hsa047201.01733989
32Collecting duct acid secretion_Homo sapiens_hsa049661.00537493
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00531151
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00260073
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95294045
36Mineral absorption_Homo sapiens_hsa049780.93831482
37Amphetamine addiction_Homo sapiens_hsa050310.93802120
38Fatty acid elongation_Homo sapiens_hsa000620.91978697
39cAMP signaling pathway_Homo sapiens_hsa040240.89632178
40Sulfur metabolism_Homo sapiens_hsa009200.89148992
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88437592
42Peroxisome_Homo sapiens_hsa041460.87938792
43* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86857802
44Synaptic vesicle cycle_Homo sapiens_hsa047210.84530302
45Histidine metabolism_Homo sapiens_hsa003400.83699809
46Taste transduction_Homo sapiens_hsa047420.83167065
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82898943
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.82858872
49Pancreatic secretion_Homo sapiens_hsa049720.82089912
50Dorso-ventral axis formation_Homo sapiens_hsa043200.81836069
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81533383
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81486190
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80960790
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.77895389
55Prion diseases_Homo sapiens_hsa050200.77444006
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.77150630
57Fructose and mannose metabolism_Homo sapiens_hsa000510.76739291
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76332813
59Renin secretion_Homo sapiens_hsa049240.76257010
60Butanoate metabolism_Homo sapiens_hsa006500.75420933
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.74646781
62Glycerolipid metabolism_Homo sapiens_hsa005610.74525565
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74342007
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72709981
65Sulfur relay system_Homo sapiens_hsa041220.72378518
66ErbB signaling pathway_Homo sapiens_hsa040120.72172419
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71662674
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71296774
69Endocytosis_Homo sapiens_hsa041440.70204325
70Serotonergic synapse_Homo sapiens_hsa047260.70159702
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69858146
72Arginine and proline metabolism_Homo sapiens_hsa003300.68023070
73Arginine biosynthesis_Homo sapiens_hsa002200.67808024
74Thyroid hormone synthesis_Homo sapiens_hsa049180.66574409
75Melanogenesis_Homo sapiens_hsa049160.66198448
76Biosynthesis of amino acids_Homo sapiens_hsa012300.66170933
77Cholinergic synapse_Homo sapiens_hsa047250.66003872
78Ether lipid metabolism_Homo sapiens_hsa005650.62059445
79Inositol phosphate metabolism_Homo sapiens_hsa005620.60984726
80Oocyte meiosis_Homo sapiens_hsa041140.60617875
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59410501
82Ras signaling pathway_Homo sapiens_hsa040140.59363470
83African trypanosomiasis_Homo sapiens_hsa051430.58918514
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.58664118
85Gap junction_Homo sapiens_hsa045400.58238187
86Cardiac muscle contraction_Homo sapiens_hsa042600.58151151
87Long-term depression_Homo sapiens_hsa047300.57564429
88Dopaminergic synapse_Homo sapiens_hsa047280.57524529
89mTOR signaling pathway_Homo sapiens_hsa041500.57374098
90AMPK signaling pathway_Homo sapiens_hsa041520.55915083
91Basal cell carcinoma_Homo sapiens_hsa052170.55316626
92Choline metabolism in cancer_Homo sapiens_hsa052310.54553372
93Glucagon signaling pathway_Homo sapiens_hsa049220.54105609
94VEGF signaling pathway_Homo sapiens_hsa043700.53904935
95Vibrio cholerae infection_Homo sapiens_hsa051100.53341047
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52589669
97MAPK signaling pathway_Homo sapiens_hsa040100.52393339
98Insulin signaling pathway_Homo sapiens_hsa049100.52065376
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51448987
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51297767
101beta-Alanine metabolism_Homo sapiens_hsa004100.50838849
102Type II diabetes mellitus_Homo sapiens_hsa049300.50025232
103ABC transporters_Homo sapiens_hsa020100.49320870
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48097192
105GnRH signaling pathway_Homo sapiens_hsa049120.48021061
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47849126
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47062973
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46274680
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.46217854
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.45629676
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45222632
112Carbon metabolism_Homo sapiens_hsa012000.45217942
113Sphingolipid metabolism_Homo sapiens_hsa006000.45024978
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44710814
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44130040
116Dilated cardiomyopathy_Homo sapiens_hsa054140.41229103
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40764431
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40690779
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39264200
120Pentose phosphate pathway_Homo sapiens_hsa000300.39222379
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38862622
122Vitamin B6 metabolism_Homo sapiens_hsa007500.38014662
123Oxytocin signaling pathway_Homo sapiens_hsa049210.37800106
124Lysosome_Homo sapiens_hsa041420.37373133
125Vitamin digestion and absorption_Homo sapiens_hsa049770.37326662
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37214473
127Pyruvate metabolism_Homo sapiens_hsa006200.33290492
128Hedgehog signaling pathway_Homo sapiens_hsa043400.33083158
129Rap1 signaling pathway_Homo sapiens_hsa040150.30772335
130Axon guidance_Homo sapiens_hsa043600.30131997
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25454390
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23484380
133Wnt signaling pathway_Homo sapiens_hsa043100.23401107
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22554448
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22534520

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