NUBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.30972342
2viral transcription (GO:0019083)5.13047549
3translational termination (GO:0006415)4.99455032
4DNA strand elongation involved in DNA replication (GO:0006271)4.93830747
5DNA deamination (GO:0045006)4.90849276
6telomere maintenance via semi-conservative replication (GO:0032201)4.86066193
7DNA strand elongation (GO:0022616)4.65991071
8ribosomal small subunit biogenesis (GO:0042274)4.55741400
9translational elongation (GO:0006414)4.50110115
10maturation of SSU-rRNA (GO:0030490)4.47763652
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.38383858
12cotranslational protein targeting to membrane (GO:0006613)4.26734726
13protein targeting to ER (GO:0045047)4.26451833
14telomere maintenance via recombination (GO:0000722)4.22291140
15translational initiation (GO:0006413)4.21581529
16formation of translation preinitiation complex (GO:0001731)4.21262917
17DNA replication initiation (GO:0006270)4.13765804
18DNA unwinding involved in DNA replication (GO:0006268)4.10226783
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.09810161
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.03409547
21ribosomal large subunit biogenesis (GO:0042273)4.02685573
22protein localization to endoplasmic reticulum (GO:0070972)4.02092353
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.00083986
24nucleotide-excision repair, DNA gap filling (GO:0006297)3.96139627
25viral life cycle (GO:0019058)3.95887330
26cellular protein complex disassembly (GO:0043624)3.91815392
27mitotic recombination (GO:0006312)3.90449617
28regulation of mitochondrial translation (GO:0070129)3.76130081
29folic acid-containing compound biosynthetic process (GO:0009396)3.66805111
30protein localization to kinetochore (GO:0034501)3.65073269
31telomere maintenance via telomere lengthening (GO:0010833)3.62287917
32ATP synthesis coupled proton transport (GO:0015986)3.57850791
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.57850791
34DNA replication checkpoint (GO:0000076)3.56953534
35ribonucleoprotein complex biogenesis (GO:0022613)3.56659759
36nucleobase biosynthetic process (GO:0046112)3.50759401
37protein complex disassembly (GO:0043241)3.49467839
38DNA replication-dependent nucleosome assembly (GO:0006335)3.45912812
39DNA replication-dependent nucleosome organization (GO:0034723)3.45912812
40regulation of cellular amino acid metabolic process (GO:0006521)3.36940618
41establishment of protein localization to mitochondrial membrane (GO:0090151)3.35229160
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.34931466
43translation (GO:0006412)3.32297327
44macromolecular complex disassembly (GO:0032984)3.30556336
45purine nucleobase biosynthetic process (GO:0009113)3.26550146
46proteasome assembly (GO:0043248)3.25586434
47ubiquinone biosynthetic process (GO:0006744)3.21154545
48cullin deneddylation (GO:0010388)3.19387029
49nuclear-transcribed mRNA catabolic process (GO:0000956)3.18167121
50respiratory electron transport chain (GO:0022904)3.13624933
51rRNA processing (GO:0006364)3.12682271
52mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.12364185
53regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.10656675
54protein localization to chromosome, centromeric region (GO:0071459)3.10630058
55protein deneddylation (GO:0000338)3.09509892
56protein complex biogenesis (GO:0070271)3.09432351
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.09283548
58immunoglobulin mediated immune response (GO:0016064)3.09261345
59ribosome biogenesis (GO:0042254)3.05937196
60IMP biosynthetic process (GO:0006188)3.05719558
61electron transport chain (GO:0022900)3.05461133
62chaperone-mediated protein transport (GO:0072321)3.05157492
63positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04669034
64transcription-coupled nucleotide-excision repair (GO:0006283)3.03380613
65ncRNA 3-end processing (GO:0043628)3.03341665
66mitotic nuclear envelope disassembly (GO:0007077)3.02727271
67mRNA catabolic process (GO:0006402)3.01439690
68rRNA metabolic process (GO:0016072)2.98994246
69spliceosomal snRNP assembly (GO:0000387)2.98758295
70positive regulation of ligase activity (GO:0051351)2.97658253
71rRNA modification (GO:0000154)2.95484711
72RNA catabolic process (GO:0006401)2.94491553
73purine deoxyribonucleotide catabolic process (GO:0009155)2.92737573
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91868332
75CENP-A containing nucleosome assembly (GO:0034080)2.91004678
76response to peptidoglycan (GO:0032494)2.90648422
77deoxyribose phosphate catabolic process (GO:0046386)2.88957278
78chromatin remodeling at centromere (GO:0031055)2.88770716
79mitochondrial respiratory chain complex assembly (GO:0033108)2.88447932
80pseudouridine synthesis (GO:0001522)2.86606197
81deoxyribonucleotide catabolic process (GO:0009264)2.86182020
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85394960
83protein targeting to mitochondrion (GO:0006626)2.84473682
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82904948
85DNA replication-independent nucleosome assembly (GO:0006336)2.82017769
86DNA replication-independent nucleosome organization (GO:0034724)2.82017769
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.81963484
88regulation of protein heterodimerization activity (GO:0043497)2.81893977
89ribosome assembly (GO:0042255)2.81337988
90negative regulation of ligase activity (GO:0051352)2.81151320
91negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81151320
92ubiquinone metabolic process (GO:0006743)2.80298457
93B cell mediated immunity (GO:0019724)2.78393743
94antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.77317585
95* iron-sulfur cluster assembly (GO:0016226)2.75275081
96* metallo-sulfur cluster assembly (GO:0031163)2.75275081
97antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.74404500
98nuclear envelope disassembly (GO:0051081)2.74290421
99membrane disassembly (GO:0030397)2.74290421
100response to interferon-beta (GO:0035456)2.74081772
101DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73309968
102pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72960037
103protein targeting to membrane (GO:0006612)2.72896037
104folic acid metabolic process (GO:0046655)2.72858239
105mitotic metaphase plate congression (GO:0007080)2.72386156
106telomere maintenance (GO:0000723)2.72328562
107telomere organization (GO:0032200)2.71350662
108GDP-mannose metabolic process (GO:0019673)2.71266303
109signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.70850920
110intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.70850920
111IMP metabolic process (GO:0046040)2.69164781
112G1/S transition of mitotic cell cycle (GO:0000082)2.68999149
113cell cycle G1/S phase transition (GO:0044843)2.68999149
114cytochrome complex assembly (GO:0017004)2.68676570
115pteridine-containing compound biosynthetic process (GO:0042559)2.68418809
116signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67813237
117signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67813237
118signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67813237
119regulation of interferon-beta biosynthetic process (GO:0045357)2.67435868
120negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.66959534
121signal transduction involved in DNA damage checkpoint (GO:0072422)2.66459646
122signal transduction involved in DNA integrity checkpoint (GO:0072401)2.66459646
123regulation of ubiquitin-protein transferase activity (GO:0051438)2.65159862
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.63690995
125cellular component biogenesis (GO:0044085)2.62764436
126DNA duplex unwinding (GO:0032508)2.62751198
127DNA geometric change (GO:0032392)2.62725993
128regulation of ligase activity (GO:0051340)2.61043645
129Arp2/3 complex-mediated actin nucleation (GO:0034314)2.60941964
130signal transduction involved in cell cycle checkpoint (GO:0072395)2.60738945
131lipopolysaccharide-mediated signaling pathway (GO:0031663)2.60640752
132translesion synthesis (GO:0019985)2.60350380
133establishment of integrated proviral latency (GO:0075713)2.59200574
134somatic hypermutation of immunoglobulin genes (GO:0016446)2.59117345
135somatic diversification of immune receptors via somatic mutation (GO:0002566)2.59117345
136negative regulation of RNA splicing (GO:0033119)2.58468438
137kinetochore organization (GO:0051383)2.57872524
138establishment of protein localization to mitochondrion (GO:0072655)2.57354231
139mannosylation (GO:0097502)2.56955087
140nucleobase-containing small molecule interconversion (GO:0015949)2.56652200
141quinone biosynthetic process (GO:1901663)2.56004611
142nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.55657440
143regulation of T cell tolerance induction (GO:0002664)2.55547693
144mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55430490
145mitochondrial respiratory chain complex I assembly (GO:0032981)2.55430490
146NADH dehydrogenase complex assembly (GO:0010257)2.55430490
147pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.52021201
148regulation of cellular amine metabolic process (GO:0033238)2.51502865
149negative regulation of myeloid cell apoptotic process (GO:0033033)2.51082427
150protein localization to mitochondrion (GO:0070585)2.50683386
151positive regulation of cell cycle arrest (GO:0071158)2.48316806
152respiratory chain complex IV assembly (GO:0008535)2.47318459
153DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.46702654
154nucleotide salvage (GO:0043173)2.46654561
155negative regulation of protein ubiquitination (GO:0031397)2.46070127
156positive regulation of T cell apoptotic process (GO:0070234)2.43173063
157pentose metabolic process (GO:0019321)2.42956528
158positive regulation of lymphocyte apoptotic process (GO:0070230)2.39186178
159purine nucleotide salvage (GO:0032261)2.38798441
160deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.38402397
161chaperone mediated protein folding requiring cofactor (GO:0051085)2.37232649
162oxidative phosphorylation (GO:0006119)2.36670687

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.61213902
2* MYC_18555785_ChIP-Seq_MESCs_Mouse3.97290741
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92481675
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.14938080
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98872325
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.79105543
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.67219968
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.66721444
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66429350
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.65731428
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.61675355
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59346785
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57601739
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.54574231
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51912506
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39395571
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.25572975
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.22987812
19XRN2_22483619_ChIP-Seq_HELA_Human2.22284026
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.15910414
21VDR_23849224_ChIP-Seq_CD4+_Human2.11856486
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11455987
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10509917
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07685504
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.04678207
26DCP1A_22483619_ChIP-Seq_HELA_Human2.03933768
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01308949
28MYC_22102868_ChIP-Seq_BL_Human1.96443145
29FOXP3_21729870_ChIP-Seq_TREG_Human1.89938976
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89089765
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.87115833
32* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87109677
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82779040
34* GABP_19822575_ChIP-Seq_HepG2_Human1.74970975
35TTF2_22483619_ChIP-Seq_HELA_Human1.68991848
36* E2F1_21310950_ChIP-Seq_MCF-7_Human1.66835719
37* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66427615
38AR_21909140_ChIP-Seq_LNCAP_Human1.61308879
39VDR_21846776_ChIP-Seq_THP-1_Human1.58939967
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.58492811
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58148263
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.54247380
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52728591
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50811559
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50383236
46* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49766422
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48733385
48CIITA_25753668_ChIP-Seq_RAJI_Human1.47083668
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46049589
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45880854
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45568447
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43828596
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43732149
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43263615
55* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42449159
56* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41425095
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40655270
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.40123776
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38901803
60ELK1_19687146_ChIP-ChIP_HELA_Human1.37290915
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34453648
62SPI1_23547873_ChIP-Seq_NB4_Human1.32940890
63KDM5A_27292631_Chip-Seq_BREAST_Human1.29912198
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28376691
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.26578085
66TFEB_21752829_ChIP-Seq_HELA_Human1.26461240
67* NOTCH1_21737748_ChIP-Seq_TLL_Human1.20575240
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17626526
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17159949
70IRF8_21731497_ChIP-ChIP_J774_Mouse1.15996370
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14512930
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14285539
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13536547
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12931246
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12600006
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.11640405
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11336442
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08923369
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08857851
80* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08824717
81STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04585745
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04488228
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04338182
84* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04081295
85MAF_26560356_Chip-Seq_TH1_Human1.03527052
86SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03488641
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02980505
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02704077
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01223521
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00484766
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00298358
92CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99450329
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99379856
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98308956
95* IRF8_27001747_Chip-Seq_BMDM_Mouse0.98139782
96UTX_26944678_Chip-Seq_JUKART_Human0.97754892
97ZNF263_19887448_ChIP-Seq_K562_Human0.97136593
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96758113
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96427818
100SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94957795
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94848915
102ELK1_22589737_ChIP-Seq_MCF10A_Human0.94104249
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93409747
104* STAT1_20625510_ChIP-Seq_HELA_Human0.93385287
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93057862
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92554384
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92266881
108MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91843223
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91828432
110CTCF_26484167_Chip-Seq_Bcells_Mouse0.91566353
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91525175
112MYC_18940864_ChIP-ChIP_HL60_Human0.91452480
113RUNX1_22412390_ChIP-Seq_EML_Mouse0.91251783
114SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91222086
115MYB_26560356_Chip-Seq_TH1_Human0.91026080
116GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90688996
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90427188
118* MYB_26560356_Chip-Seq_TH2_Human0.89853132
119BCL6_27268052_Chip-Seq_Bcells_Human0.89777019
120MAF_26560356_Chip-Seq_TH2_Human0.89010821
121* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88256142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.26251650
2MP0010094_abnormal_chromosome_stability3.50980061
3MP0004957_abnormal_blastocyst_morpholog3.50022201
4MP0003111_abnormal_nucleus_morphology3.34479181
5MP0003077_abnormal_cell_cycle3.06982432
6MP0008057_abnormal_DNA_replication2.72910747
7MP0001835_abnormal_antigen_presentation2.61515423
8MP0008058_abnormal_DNA_repair2.59895562
9MP0002396_abnormal_hematopoietic_system2.53538381
10MP0000372_irregular_coat_pigmentation2.42090080
11MP0008007_abnormal_cellular_replicative2.41008365
12MP0010352_gastrointestinal_tract_polyps2.25164230
13MP0003763_abnormal_thymus_physiology2.18763721
14MP0000490_abnormal_crypts_of2.17107171
15MP0005058_abnormal_lysosome_morphology2.15973047
16MP0000685_abnormal_immune_system2.11897071
17MP0009333_abnormal_splenocyte_physiolog2.10577931
18MP0002139_abnormal_hepatobiliary_system2.10218974
19MP0003195_calcinosis2.08397607
20MP0000343_altered_response_to2.01046180
21MP0008932_abnormal_embryonic_tissue1.98324492
22MP0001800_abnormal_humoral_immune1.95089856
23MP0003786_premature_aging1.93901815
24MP0003436_decreased_susceptibility_to1.86358335
25MP0002398_abnormal_bone_marrow1.84114906
26MP0009785_altered_susceptibility_to1.81797051
27MP0009278_abnormal_bone_marrow1.78460580
28MP0001730_embryonic_growth_arrest1.78221608
29MP0000350_abnormal_cell_proliferation1.77718751
30MP0005671_abnormal_response_to1.76991748
31MP0002452_abnormal_antigen_presenting1.71435787
32MP0003191_abnormal_cellular_cholesterol1.65004498
33MP0005000_abnormal_immune_tolerance1.63553674
34MP0000689_abnormal_spleen_morphology1.63405606
35MP0002722_abnormal_immune_system1.63057525
36MP0005025_abnormal_response_to1.61616338
37MP0002723_abnormal_immune_serum1.60953392
38MP0002420_abnormal_adaptive_immunity1.60899920
39MP0001819_abnormal_immune_cell1.58916247
40MP0002019_abnormal_tumor_incidence1.54819913
41MP0010307_abnormal_tumor_latency1.52563194
42MP0000716_abnormal_immune_system1.51841585
43MP0003806_abnormal_nucleotide_metabolis1.51236007
44MP0002429_abnormal_blood_cell1.50231896
45MP0009840_abnormal_foam_cell1.49045100
46MP0001853_heart_inflammation1.48745095
47MP0002405_respiratory_system_inflammati1.44470574
48MP0000703_abnormal_thymus_morphology1.43709182
49MP0000313_abnormal_cell_death1.42478213
50MP0002837_dystrophic_cardiac_calcinosis1.42442525
51MP0002277_abnormal_respiratory_mucosa1.42086655
52MP0002148_abnormal_hypersensitivity_rea1.41582848
53MP0005387_immune_system_phenotype1.41300211
54MP0001790_abnormal_immune_system1.41300211
55MP0000858_altered_metastatic_potential1.40416923
56MP0004808_abnormal_hematopoietic_stem1.38060325
57MP0003186_abnormal_redox_activity1.36602247
58MP0009764_decreased_sensitivity_to1.35203303
59MP0003303_peritoneal_inflammation1.34093227
60MP0001545_abnormal_hematopoietic_system1.27379412
61MP0005397_hematopoietic_system_phenotyp1.27379412
62MP0002166_altered_tumor_susceptibility1.27224564
63MP0010155_abnormal_intestine_physiology1.26292379
64MP0002080_prenatal_lethality1.23983866
65MP0008260_abnormal_autophagy1.22976698
66MP0009379_abnormal_foot_pigmentation1.19235518
67MP0005166_decreased_susceptibility_to1.19096331
68MP0002419_abnormal_innate_immunity1.18736025
69MP0001533_abnormal_skeleton_physiology1.17972221
70MP0001697_abnormal_embryo_size1.16644869
71MP0002138_abnormal_hepatobiliary_system1.16120540
72MP0001672_abnormal_embryogenesis/_devel1.14299256
73MP0005380_embryogenesis_phenotype1.14299256
74MP0003646_muscle_fatigue1.14019607
75MP0002006_tumorigenesis1.10938499
76MP0005075_abnormal_melanosome_morpholog1.08874511
77MP0003075_altered_response_to1.08266027
78MP0001873_stomach_inflammation1.07017255
79MP0005084_abnormal_gallbladder_morpholo1.05755949
80MP0005023_abnormal_wound_healing1.05405027
81MP0001845_abnormal_inflammatory_respons1.05376946
82MP0003984_embryonic_growth_retardation1.04751289
83MP0003866_abnormal_defecation1.03626037
84MP0009697_abnormal_copulation1.02926142
85MP0002088_abnormal_embryonic_growth/wei1.02541458
86MP0006082_CNS_inflammation1.02163504
87MP0005464_abnormal_platelet_physiology1.00908289
88MP0005174_abnormal_tail_pigmentation0.98019688
89MP0005319_abnormal_enzyme/_coenzyme0.98018726
90MP0003172_abnormal_lysosome_physiology0.97188562
91MP0006054_spinal_hemorrhage0.97046751
92MP0000358_abnormal_cell_content/0.95948466
93MP0002086_abnormal_extraembryonic_tissu0.93275550
94MP0005310_abnormal_salivary_gland0.92710167
95MP0005451_abnormal_body_composition0.92294230
96MP0008469_abnormal_protein_level0.90264159
97MP0003123_paternal_imprinting0.90029018
98MP0002254_reproductive_system_inflammat0.89193760
99MP0002085_abnormal_embryonic_tissue0.88044010
100MP0005076_abnormal_cell_differentiation0.87847027
101MP0005408_hypopigmentation0.84824177
102MP0000477_abnormal_intestine_morphology0.84147727
103MP0004947_skin_inflammation0.80471858
104MP0009765_abnormal_xenobiotic_induced0.80308034
105MP0005584_abnormal_enzyme/coenzyme_acti0.79327682
106MP0003724_increased_susceptibility_to0.79047721
107MP0008875_abnormal_xenobiotic_pharmacok0.78526845
108MP0005332_abnormal_amino_acid0.77314491
109MP0000371_diluted_coat_color0.77050573
110MP0004510_myositis0.76860541
111MP0002095_abnormal_skin_pigmentation0.75690776
112MP0004197_abnormal_fetal_growth/weight/0.75554557
113MP0000609_abnormal_liver_physiology0.75424460
114MP0000598_abnormal_liver_morphology0.75216534
115MP0005330_cardiomyopathy0.74040870
116MP0003448_altered_tumor_morphology0.73792132
117MP0006036_abnormal_mitochondrial_physio0.73585205
118MP0002933_joint_inflammation0.72114526
119MP0002132_abnormal_respiratory_system0.71404782
120MP0005636_abnormal_mineral_homeostasis0.71317528
121MP0002084_abnormal_developmental_patter0.70305021
122MP0003656_abnormal_erythrocyte_physiolo0.69990578
123MP0003221_abnormal_cardiomyocyte_apopto0.69687980
124MP0003718_maternal_effect0.69668253
125MP0003567_abnormal_fetal_cardiomyocyte0.69328470
126MP0008873_increased_physiological_sensi0.68856354
127MP0000015_abnormal_ear_pigmentation0.68408851
128MP0001764_abnormal_homeostasis0.68380112
129MP0009053_abnormal_anal_canal0.66844848
130MP0005266_abnormal_metabolism0.65475378
131MP0005621_abnormal_cell_physiology0.64929469
132MP0005165_increased_susceptibility_to0.64677260
133MP0005083_abnormal_biliary_tract0.64510921
134MP0006035_abnormal_mitochondrial_morpho0.64214556
135MP0005384_cellular_phenotype0.64090662
136MP0009763_increased_sensitivity_to0.63342217
137MP0000465_gastrointestinal_hemorrhage0.60252995
138MP0001293_anophthalmia0.58744713

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.98997572
2Reticulocytopenia (HP:0001896)4.90394572
3Abnormal number of erythroid precursors (HP:0012131)4.62046778
4Abnormal mitochondria in muscle tissue (HP:0008316)4.36088713
5Acute necrotizing encephalopathy (HP:0006965)4.34158898
6Increased intramyocellular lipid droplets (HP:0012240)4.21940665
7Mitochondrial inheritance (HP:0001427)4.15648958
8Increased CSF lactate (HP:0002490)3.99782416
9Increased hepatocellular lipid droplets (HP:0006565)3.97126945
10Renal Fanconi syndrome (HP:0001994)3.86072528
11Acute encephalopathy (HP:0006846)3.84296938
12Increased muscle lipid content (HP:0009058)3.66480771
13Lipid accumulation in hepatocytes (HP:0006561)3.64959836
14Macrocytic anemia (HP:0001972)3.55731563
15Pallor (HP:0000980)3.55628682
16Hepatocellular necrosis (HP:0001404)3.46861045
17Hepatic necrosis (HP:0002605)3.37174260
18Birth length less than 3rd percentile (HP:0003561)3.35522371
19Progressive macrocephaly (HP:0004481)3.35146064
20Thrombocytosis (HP:0001894)3.33887019
21Oral leukoplakia (HP:0002745)3.22639556
22IgM deficiency (HP:0002850)3.19171883
23Respiratory difficulties (HP:0002880)3.15953933
24Elevated erythrocyte sedimentation rate (HP:0003565)3.07780386
25Aplastic anemia (HP:0001915)3.06443870
26Cerebral edema (HP:0002181)3.01994133
27Lactic acidosis (HP:0003128)2.97968608
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.90605805
29Multiple enchondromatosis (HP:0005701)2.85744802
30Breast hypoplasia (HP:0003187)2.84337393
31Abnormality of T cell physiology (HP:0011840)2.80815524
32Ragged-red muscle fibers (HP:0003200)2.79491804
33Vacuolated lymphocytes (HP:0001922)2.78216266
34Microretrognathia (HP:0000308)2.75179477
35Poikiloderma (HP:0001029)2.68041621
36Abnormality of the anterior horn cell (HP:0006802)2.67976178
37Degeneration of anterior horn cells (HP:0002398)2.67976178
38Rough bone trabeculation (HP:0100670)2.67652930
3911 pairs of ribs (HP:0000878)2.65639944
40Exercise intolerance (HP:0003546)2.65526275
41Selective tooth agenesis (HP:0001592)2.64480933
42Abnormality of aromatic amino acid family metabolism (HP:0004338)2.60566894
43Abnormality of T cells (HP:0002843)2.59712712
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59388538
45Respiratory failure (HP:0002878)2.55244362
46Abnormality of liposaccharide metabolism (HP:0010968)2.52898509
47Abnormality of glycosphingolipid metabolism (HP:0004343)2.52898509
48Abnormality of glycolipid metabolism (HP:0010969)2.52898509
49Trismus (HP:0000211)2.52818582
50Lymphoma (HP:0002665)2.46288275
51Poor head control (HP:0002421)2.45481366
52Combined immunodeficiency (HP:0005387)2.45279669
53Increased serum pyruvate (HP:0003542)2.43000449
54Recurrent bronchitis (HP:0002837)2.40372314
55Agnosia (HP:0010524)2.38957632
56Absent thumb (HP:0009777)2.38308022
57Recurrent abscess formation (HP:0002722)2.34345033
58IgG deficiency (HP:0004315)2.34194943
59Recurrent viral infections (HP:0004429)2.34047250
60Lethargy (HP:0001254)2.33285928
61Colon cancer (HP:0003003)2.31051185
62Recurrent skin infections (HP:0001581)2.30206862
63Abnormality of macrophages (HP:0004311)2.30028772
64Progressive muscle weakness (HP:0003323)2.29901579
65Abnormality of glycolysis (HP:0004366)2.28587605
66Increased cerebral lipofuscin (HP:0011813)2.28441835
673-Methylglutaconic aciduria (HP:0003535)2.27794121
68Cerebral hypomyelination (HP:0006808)2.26583487
69Abnormality of renal resorption (HP:0011038)2.26503147
70Abnormality of reticulocytes (HP:0004312)2.26441355
71Chromsome breakage (HP:0040012)2.26252262
72Autoimmune thrombocytopenia (HP:0001973)2.26082882
73Decreased activity of mitochondrial respiratory chain (HP:0008972)2.24882366
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.24882366
75Entropion (HP:0000621)2.23610010
76Acute hepatic failure (HP:0006554)2.23029729
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22750001
78Dicarboxylic aciduria (HP:0003215)2.22750001
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.22657073
80Recurrent cutaneous fungal infections (HP:0011370)2.21988473
81Chronic mucocutaneous candidiasis (HP:0002728)2.21988473
82Abnormal protein glycosylation (HP:0012346)2.21941321
83Abnormal glycosylation (HP:0012345)2.21941321
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21941321
85Abnormal protein N-linked glycosylation (HP:0012347)2.21941321
86Basal cell carcinoma (HP:0002671)2.20792815
87Premature graying of hair (HP:0002216)2.18366942
88Abnormality of the preputium (HP:0100587)2.16743469
89Cellular immunodeficiency (HP:0005374)2.16322233
90Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15625750
91Severe combined immunodeficiency (HP:0004430)2.15157004
92Nausea (HP:0002018)2.13090593
93Generalized aminoaciduria (HP:0002909)2.11406480
94Increased neuronal autofluorescent lipopigment (HP:0002074)2.11387553
95Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11040159
96Glycosuria (HP:0003076)2.10339419
97Abnormality of urine glucose concentration (HP:0011016)2.10339419
98Myelodysplasia (HP:0002863)2.09480180
99Bone marrow hypocellularity (HP:0005528)2.09250103
100Abnormality of chromosome stability (HP:0003220)2.09141745
101Systemic lupus erythematosus (HP:0002725)2.08227796
102Methylmalonic aciduria (HP:0012120)2.08227789
103Abnormality of pyrimidine metabolism (HP:0004353)2.08112677
104Neoplasm of the pancreas (HP:0002894)2.07897448
105Abnormality of cells of the lymphoid lineage (HP:0012140)2.07770218
106Petechiae (HP:0000967)2.06835154
107Pancytopenia (HP:0001876)2.05849872
108Parakeratosis (HP:0001036)2.05521238
109Microvesicular hepatic steatosis (HP:0001414)2.04339322
110Recurrent bacterial skin infections (HP:0005406)2.03267458
111Hypertensive crisis (HP:0100735)2.02316735
112Recurrent fungal infections (HP:0002841)2.01576426
113Eczematoid dermatitis (HP:0000976)2.01396088
114Chronic otitis media (HP:0000389)2.01044183
115Encephalitis (HP:0002383)2.00910766
116Colitis (HP:0002583)2.00289814
117Hepatosplenomegaly (HP:0001433)2.00277060
118Meckel diverticulum (HP:0002245)1.99409265
119Meningitis (HP:0001287)1.98100160
120Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.97791134
121Cleft eyelid (HP:0000625)1.97714513
122Personality changes (HP:0000751)1.97542320
123Type I transferrin isoform profile (HP:0003642)1.96957735
124Carpal bone hypoplasia (HP:0001498)1.96304967
125B lymphocytopenia (HP:0010976)1.95247257
126Abnormality of B cell number (HP:0010975)1.95247257
127Premature ovarian failure (HP:0008209)1.93840178
128Amaurosis fugax (HP:0100576)1.93128838
129T lymphocytopenia (HP:0005403)1.92954182
130Abnormality of T cell number (HP:0011839)1.92793274
131Patellar aplasia (HP:0006443)1.92516470
132Pustule (HP:0200039)1.92348482
133Abnormality of the ileum (HP:0001549)1.91001565
134Lymphopenia (HP:0001888)1.90679548
135Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90600772
136Recurrent gram-negative bacterial infections (HP:0005420)1.90574302
137Progressive neurologic deterioration (HP:0002344)1.88176193
138Abnormal trabecular bone morphology (HP:0100671)1.87741482
139Aplasia/Hypoplasia of the uvula (HP:0010293)1.87622469
140Increased IgM level (HP:0003496)1.86677147
141Leukopenia (HP:0001882)1.86616509
142Reduced antithrombin III activity (HP:0001976)1.86489136
143Aplasia/Hypoplasia of the patella (HP:0006498)1.84871688
144Granulocytopenia (HP:0001913)1.83919235
145Exertional dyspnea (HP:0002875)1.83826391
146Hyperphosphaturia (HP:0003109)1.81775904
147Increased serum lactate (HP:0002151)1.81204396
148Optic disc pallor (HP:0000543)1.81151000
149Cellulitis (HP:0100658)1.80090216
150Hypokinesia (HP:0002375)1.79856108
151Aplasia/Hypoplasia of the thymus (HP:0010515)1.79093293
152Hyperglycinemia (HP:0002154)1.78479642
153Impulsivity (HP:0100710)1.78448318
154Increased serum ferritin (HP:0003281)1.78166515
155Cholecystitis (HP:0001082)1.77882052
156Abnormal gallbladder physiology (HP:0012438)1.77882052
157Orthostatic hypotension (HP:0001278)1.77539597
158Inflammation of the large intestine (HP:0002037)1.77494423
159Medulloblastoma (HP:0002885)1.77110482
160Abnormality of DNA repair (HP:0003254)1.76850342
161Panhypogammaglobulinemia (HP:0003139)1.76269638
162Stomatitis (HP:0010280)1.76256464
163Prolonged neonatal jaundice (HP:0006579)1.76163368
164Myoglobinuria (HP:0002913)1.76015350
165Atrophy/Degeneration involving motor neurons (HP:0007373)1.74960783
166Prominent metopic ridge (HP:0005487)1.74608156
167Agammaglobulinemia (HP:0004432)1.74576968
168Tracheoesophageal fistula (HP:0002575)1.74373689
169Rhabdomyosarcoma (HP:0002859)1.71265115
170Obstructive lung disease (HP:0006536)1.71065193
171Chronic obstructive pulmonary disease (HP:0006510)1.71065193
172Ependymoma (HP:0002888)1.70603015
173Mediastinal lymphadenopathy (HP:0100721)1.70214524

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.10606096
2BUB13.81387660
3NME23.50923246
4EIF2AK13.06349076
5WEE13.04184204
6CDC72.94448874
7MAP4K12.94183858
8TLK12.66187472
9TESK22.65780135
10SCYL22.20001645
11NEK22.13078135
12BLK2.12692388
13PDK22.08513198
14MAP3K101.97223753
15EIF2AK31.95921155
16STK161.88572060
17KDR1.72455765
18MAP4K21.70829600
19PIM21.68205878
20BRSK21.63405494
21RPS6KA41.58088642
22GRK61.56513814
23GRK71.55554566
24MUSK1.55362526
25MAP3K121.53729169
26ACVR1B1.53060112
27STK101.49694519
28SRPK11.48302161
29ZAP701.47240403
30TRIM281.35704710
31TESK11.35430283
32RPS6KB21.35392783
33TYK21.35306106
34DYRK31.34990712
35PLK11.34211113
36CDK71.31800649
37TBK11.30929330
38LRRK21.30504972
39AURKB1.26890404
40PASK1.26460518
41IRAK41.24722271
42MAP3K81.24277070
43NUAK11.23310521
44TTK1.21527735
45VRK11.21241426
46EPHA21.16649688
47SMG11.15618396
48IRAK31.15178419
49BMPR21.13981853
50TGFBR11.13823258
51PIM11.13410578
52PAK41.12766990
53MAP2K31.12417489
54ERN11.10845739
55MAP3K111.10472782
56RIPK41.09538931
57CDK41.07207420
58MAP3K51.05171349
59ATR1.05032080
60EEF2K1.04906762
61PLK41.01647736
62NEK11.01533408
63FLT30.99719961
64BRSK10.97726152
65TAOK30.96368379
66MAP3K140.96230728
67PKN20.95677586
68JAK30.94883812
69AURKA0.94523773
70BTK0.91850277
71STK40.91491865
72TAOK20.90335728
73DAPK30.90301075
74TSSK60.87364760
75DAPK10.86279694
76BCKDK0.83419437
77MATK0.81276399
78ARAF0.80875006
79MKNK10.80226624
80BRAF0.79084815
81PBK0.78248237
82TEC0.75226205
83SYK0.74971780
84CSF1R0.74627671
85IKBKB0.73682252
86KIT0.73443718
87ADRBK20.72801637
88CHEK20.71879535
89TXK0.69338188
90TGFBR20.66629070
91CHEK10.65335142
92ILK0.64787961
93MAP3K30.63197588
94TAF10.63124816
95TAOK10.62648613
96EIF2AK20.61419059
97MST40.61172983
98PAK10.60151898
99IKBKE0.59601819
100NEK90.58851330
101LYN0.57913263
102LIMK10.56998482
103MAPKAPK50.55689741
104JAK10.54532484
105CSNK2A20.54511246
106CSK0.53417976
107PRKCI0.52942246
108PLK30.52508723
109MKNK20.51445001
110TRIB30.51433942
111ZAK0.51354889
112CDK120.50919487
113LCK0.50205799
114CSNK2A10.50133683
115CDK20.48033560
116CHUK0.47579806
117IRAK10.47361799
118CSNK1G30.46603621
119FGR0.46006215
120MAPKAPK30.45639347
121MAP2K20.44931021
122MARK30.44796162
123RPS6KA50.42853027
124BMPR1B0.42819808
125ABL20.41619311
126FES0.41502665
127FGFR40.41215408
128ITK0.40257925
129NME10.39704291
130CDK60.39580370
131MELK0.37218206
132TNK20.34701631
133PRKCQ0.34332440

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.00799746
2Ribosome_Homo sapiens_hsa030104.28022292
3Mismatch repair_Homo sapiens_hsa034304.06738440
4Proteasome_Homo sapiens_hsa030503.35346815
5Base excision repair_Homo sapiens_hsa034102.98017525
6Nucleotide excision repair_Homo sapiens_hsa034202.74969420
7Spliceosome_Homo sapiens_hsa030402.70493899
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64589721
9Homologous recombination_Homo sapiens_hsa034402.64581900
10RNA polymerase_Homo sapiens_hsa030202.54391020
11One carbon pool by folate_Homo sapiens_hsa006702.50476995
12Pyrimidine metabolism_Homo sapiens_hsa002402.37786708
13RNA transport_Homo sapiens_hsa030132.27564430
14Cell cycle_Homo sapiens_hsa041101.92004987
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89873087
16Sulfur relay system_Homo sapiens_hsa041221.76077663
17Rheumatoid arthritis_Homo sapiens_hsa053231.66368979
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64503350
19Autoimmune thyroid disease_Homo sapiens_hsa053201.63229212
20Alzheimers disease_Homo sapiens_hsa050101.59474700
21Primary immunodeficiency_Homo sapiens_hsa053401.58416895
22Type I diabetes mellitus_Homo sapiens_hsa049401.55548668
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54730741
24Fanconi anemia pathway_Homo sapiens_hsa034601.51979159
25Sulfur metabolism_Homo sapiens_hsa009201.50863165
26Fatty acid elongation_Homo sapiens_hsa000621.47565579
27Non-homologous end-joining_Homo sapiens_hsa034501.44084947
28Staphylococcus aureus infection_Homo sapiens_hsa051501.37957176
29p53 signaling pathway_Homo sapiens_hsa041151.36784823
30Systemic lupus erythematosus_Homo sapiens_hsa053221.33183356
31Antigen processing and presentation_Homo sapiens_hsa046121.30514379
32Folate biosynthesis_Homo sapiens_hsa007901.28719005
33RNA degradation_Homo sapiens_hsa030181.23707390
34Epstein-Barr virus infection_Homo sapiens_hsa051691.17002458
35Herpes simplex infection_Homo sapiens_hsa051681.15627891
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.12141345
37Protein export_Homo sapiens_hsa030601.06969496
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06630690
39Basal transcription factors_Homo sapiens_hsa030221.05632836
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05339504
41Pentose phosphate pathway_Homo sapiens_hsa000301.05053612
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04996675
43Legionellosis_Homo sapiens_hsa051341.01791035
44Purine metabolism_Homo sapiens_hsa002300.98426825
45mRNA surveillance pathway_Homo sapiens_hsa030150.98302097
46Viral carcinogenesis_Homo sapiens_hsa052030.98164323
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.98026530
48Lysosome_Homo sapiens_hsa041420.93680390
49Tuberculosis_Homo sapiens_hsa051520.91669629
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.88254076
51Measles_Homo sapiens_hsa051620.84830535
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83219745
53Peroxisome_Homo sapiens_hsa041460.81844725
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80664006
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79444963
56Selenocompound metabolism_Homo sapiens_hsa004500.78079899
57Apoptosis_Homo sapiens_hsa042100.76618735
58Cardiac muscle contraction_Homo sapiens_hsa042600.76441744
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.76414390
60Leishmaniasis_Homo sapiens_hsa051400.75569451
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69506359
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.69149064
63Shigellosis_Homo sapiens_hsa051310.68612782
64B cell receptor signaling pathway_Homo sapiens_hsa046620.66660335
65Parkinsons disease_Homo sapiens_hsa050120.66303859
66Biosynthesis of amino acids_Homo sapiens_hsa012300.66228283
67Malaria_Homo sapiens_hsa051440.65517104
68Collecting duct acid secretion_Homo sapiens_hsa049660.65042358
69HTLV-I infection_Homo sapiens_hsa051660.65018238
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64900358
71Salmonella infection_Homo sapiens_hsa051320.64526857
72Pyruvate metabolism_Homo sapiens_hsa006200.62752871
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62165470
74Phagosome_Homo sapiens_hsa041450.61848930
75Hematopoietic cell lineage_Homo sapiens_hsa046400.60275172
76Glutathione metabolism_Homo sapiens_hsa004800.59399472
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57755644
78N-Glycan biosynthesis_Homo sapiens_hsa005100.56842225
79Huntingtons disease_Homo sapiens_hsa050160.56834839
80Allograft rejection_Homo sapiens_hsa053300.56139814
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55856848
82Asthma_Homo sapiens_hsa053100.55805070
83Thyroid cancer_Homo sapiens_hsa052160.53541107
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51372666
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48954875
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48717085
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48599831
88Oxidative phosphorylation_Homo sapiens_hsa001900.48295406
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47526064
90Fructose and mannose metabolism_Homo sapiens_hsa000510.47367575
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47267782
92Propanoate metabolism_Homo sapiens_hsa006400.46533088
93Influenza A_Homo sapiens_hsa051640.46375746
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46045684
95Viral myocarditis_Homo sapiens_hsa054160.45826191
96Hepatitis B_Homo sapiens_hsa051610.45451121
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45016080
98Small cell lung cancer_Homo sapiens_hsa052220.44098429
99Carbon metabolism_Homo sapiens_hsa012000.43759612
100Galactose metabolism_Homo sapiens_hsa000520.43064335
101T cell receptor signaling pathway_Homo sapiens_hsa046600.40767924
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.40239790
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40051263
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37879948
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36389131
106Acute myeloid leukemia_Homo sapiens_hsa052210.35613355
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35391318
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35307720
109Steroid biosynthesis_Homo sapiens_hsa001000.35195950
110Graft-versus-host disease_Homo sapiens_hsa053320.34795775
111Other glycan degradation_Homo sapiens_hsa005110.33869711
112Caffeine metabolism_Homo sapiens_hsa002320.33513050
113Chronic myeloid leukemia_Homo sapiens_hsa052200.31252759
114Pertussis_Homo sapiens_hsa051330.29693141
115Osteoclast differentiation_Homo sapiens_hsa043800.28839894
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28318552
117Bladder cancer_Homo sapiens_hsa052190.27967770
118Alcoholism_Homo sapiens_hsa050340.27520022
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.26833552
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26820057
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25978496
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.25520478
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24487454
124Toxoplasmosis_Homo sapiens_hsa051450.24113347
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24009487
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22938724
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22722222
128Metabolic pathways_Homo sapiens_hsa011000.22714177
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21990980

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