NUCKS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.84998295
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.76838343
3nuclear pore organization (GO:0006999)5.70590077
4mitotic sister chromatid cohesion (GO:0007064)5.66977422
5DNA unwinding involved in DNA replication (GO:0006268)5.43333150
6protein localization to kinetochore (GO:0034501)5.33469191
7kinetochore organization (GO:0051383)5.14240036
8sister chromatid segregation (GO:0000819)5.09755227
9mitotic chromosome condensation (GO:0007076)4.93070995
10mitotic sister chromatid segregation (GO:0000070)4.62097317
11pore complex assembly (GO:0046931)4.37850163
12protein localization to chromosome, centromeric region (GO:0071459)4.37564638
13regulation of DNA endoreduplication (GO:0032875)4.28248863
14pre-miRNA processing (GO:0031054)4.26914382
15mitotic metaphase plate congression (GO:0007080)4.26492167
16DNA replication-dependent nucleosome assembly (GO:0006335)4.18022457
17DNA replication-dependent nucleosome organization (GO:0034723)4.18022457
18regulation of histone H3-K9 methylation (GO:0051570)4.15416580
19DNA topological change (GO:0006265)4.11173973
20positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.08622145
21positive regulation of mitotic sister chromatid separation (GO:1901970)4.08622145
22positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.08622145
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.04965236
24establishment of integrated proviral latency (GO:0075713)4.04124107
25kinetochore assembly (GO:0051382)4.02852838
26DNA duplex unwinding (GO:0032508)4.00668876
27DNA geometric change (GO:0032392)4.00655983
28mitotic nuclear envelope disassembly (GO:0007077)3.99612484
29metaphase plate congression (GO:0051310)3.95696993
30regulation of sister chromatid cohesion (GO:0007063)3.95166761
31regulation of spindle organization (GO:0090224)3.92165900
32positive regulation of chromosome segregation (GO:0051984)3.90721863
33regulation of RNA export from nucleus (GO:0046831)3.83638977
34nuclear envelope disassembly (GO:0051081)3.80748663
35membrane disassembly (GO:0030397)3.80748663
36negative regulation of histone methylation (GO:0031061)3.75784240
37chromatin remodeling at centromere (GO:0031055)3.74143605
38regulation of mitotic spindle organization (GO:0060236)3.71189278
39chromatin assembly (GO:0031497)3.69327535
40regulation of centriole replication (GO:0046599)3.67198258
41CENP-A containing nucleosome assembly (GO:0034080)3.66414655
42establishment of chromosome localization (GO:0051303)3.63358959
43dosage compensation (GO:0007549)3.59622748
44attachment of spindle microtubules to kinetochore (GO:0008608)3.57558280
45regulation of centrosome cycle (GO:0046605)3.56831503
46DNA replication-independent nucleosome assembly (GO:0006336)3.51574126
47DNA replication-independent nucleosome organization (GO:0034724)3.51574126
48spindle checkpoint (GO:0031577)3.51238336
49negative regulation of DNA repair (GO:0045738)3.50201388
50DNA replication initiation (GO:0006270)3.49980782
51chromatin assembly or disassembly (GO:0006333)3.48897300
52regulation of chromosome segregation (GO:0051983)3.44094971
53regulation of mitotic metaphase/anaphase transition (GO:0030071)3.39398357
54meiotic chromosome segregation (GO:0045132)3.36393560
55chromosome condensation (GO:0030261)3.34903998
56regulation of centrosome duplication (GO:0010824)3.34645871
57DNA conformation change (GO:0071103)3.34408199
58protein complex localization (GO:0031503)3.31845935
59spindle assembly checkpoint (GO:0071173)3.31387305
60regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.29952740
61chromosome segregation (GO:0007059)3.29365169
62histone exchange (GO:0043486)3.28686680
63protein localization to chromosome (GO:0034502)3.26168082
64DNA strand elongation involved in DNA replication (GO:0006271)3.25226957
65nucleosome disassembly (GO:0006337)3.25002347
66protein-DNA complex disassembly (GO:0032986)3.25002347
67notochord development (GO:0030903)3.24395658
68mitotic recombination (GO:0006312)3.23907179
69regulation of sister chromatid segregation (GO:0033045)3.23050464
70regulation of mitotic sister chromatid separation (GO:0010965)3.23050464
71regulation of mitotic sister chromatid segregation (GO:0033047)3.23050464
72mitotic spindle checkpoint (GO:0071174)3.21627699
73regulation of posttranscriptional gene silencing (GO:0060147)3.21600604
74regulation of gene silencing by miRNA (GO:0060964)3.21600604
75regulation of gene silencing by RNA (GO:0060966)3.21600604
76ATP-dependent chromatin remodeling (GO:0043044)3.21384242
77heterochromatin organization (GO:0070828)3.19570822
78negative regulation of chromosome segregation (GO:0051985)3.16032597
79mitotic spindle assembly checkpoint (GO:0007094)3.13496066
80IMP biosynthetic process (GO:0006188)3.13415140
81negative regulation of mitotic sister chromatid separation (GO:2000816)3.12712799
82negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12712799
83negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12712799
84negative regulation of sister chromatid segregation (GO:0033046)3.12712799
85glucocorticoid receptor signaling pathway (GO:0042921)3.10543065
86folic acid-containing compound biosynthetic process (GO:0009396)3.10237849
87RNA stabilization (GO:0043489)3.09516025
88mRNA stabilization (GO:0048255)3.09516025
89regulation of helicase activity (GO:0051095)3.08255137
90DNA strand elongation (GO:0022616)3.05699771
91negative regulation of DNA-dependent DNA replication (GO:2000104)3.05336719
92DNA ligation (GO:0006266)3.02997838
93DNA packaging (GO:0006323)3.01722486
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01273929
95cellular protein complex localization (GO:0034629)3.00429075
96mitotic DNA integrity checkpoint (GO:0044774)2.98503311
97regulation of translational fidelity (GO:0006450)2.97121830
98DNA replication checkpoint (GO:0000076)2.95569343
99somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95144247
100somatic hypermutation of immunoglobulin genes (GO:0016446)2.95144247
101regulation of nucleobase-containing compound transport (GO:0032239)2.93168883
102protein K6-linked ubiquitination (GO:0085020)2.92028295
103nuclear envelope organization (GO:0006998)2.91396103
104sister chromatid cohesion (GO:0007062)2.90321187
105paraxial mesoderm development (GO:0048339)2.89966854
106microtubule depolymerization (GO:0007019)2.89931285
107translesion synthesis (GO:0019985)2.83848086
108NLS-bearing protein import into nucleus (GO:0006607)2.83147791
109telomere maintenance via semi-conservative replication (GO:0032201)2.79352111
110mitotic cytokinesis (GO:0000281)2.76633159
111double-strand break repair via nonhomologous end joining (GO:0006303)2.75579911
112non-recombinational repair (GO:0000726)2.75579911
113positive regulation of cell cycle G2/M phase transition (GO:1902751)2.70725755
114positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.70725755
115establishment of viral latency (GO:0019043)2.70058159
116planar cell polarity pathway involved in neural tube closure (GO:0090179)2.66617923
117mitotic spindle organization (GO:0007052)2.60830684
118maturation of SSU-rRNA (GO:0030490)2.58044143
119convergent extension (GO:0060026)2.57506887
120regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43789734
121apical protein localization (GO:0045176)2.41742441
122hippo signaling (GO:0035329)2.40955543
123histone H2B ubiquitination (GO:0033523)2.39294305
124generation of neurons (GO:0048699)2.38185659
125establishment of mitotic spindle localization (GO:0040001)2.36683822
126negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.35286358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human6.77966990
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human5.14012912
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.86930547
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.74442355
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.39942754
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.27664786
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.24831882
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.23075901
9* MYC_18555785_ChIP-Seq_MESCs_Mouse3.18990402
10RBPJ_22232070_ChIP-Seq_NCS_Mouse3.15471959
11AR_21909140_ChIP-Seq_LNCAP_Human2.72441561
12* E2F1_21310950_ChIP-Seq_MCF-7_Human2.56041633
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49547273
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.21853639
15* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16171172
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03604791
17E2F7_22180533_ChIP-Seq_HELA_Human11.6618370
18TP63_19390658_ChIP-ChIP_HaCaT_Human1.93860064
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.87039129
20* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.84802372
21ESR1_15608294_ChIP-ChIP_MCF-7_Human1.74938426
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.71954405
23SOX2_18555785_ChIP-Seq_MESCs_Mouse1.64869407
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64026826
25YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63056047
26* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60133608
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59958996
28* ELK1_19687146_ChIP-ChIP_HELA_Human1.59872963
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58440882
30MYC_22102868_ChIP-Seq_BL_Human1.57594225
31SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.56447477
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55338904
33XRN2_22483619_ChIP-Seq_HELA_Human1.54039354
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51285811
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50197625
36SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.49228255
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.43434302
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.43434302
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.43434302
40* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40709752
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39035783
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38313206
43* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31519239
44TTF2_22483619_ChIP-Seq_HELA_Human1.30484609
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.27760007
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26208865
47KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25678111
48* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25652989
49SOX2_16153702_ChIP-ChIP_HESCs_Human1.25581615
50* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24697045
51CIITA_25753668_ChIP-Seq_RAJI_Human1.20951957
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20704662
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.19809871
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18542830
55* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17100112
56* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.17098174
57VDR_23849224_ChIP-Seq_CD4+_Human1.16755627
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16264196
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15902963
60KDM5A_27292631_Chip-Seq_BREAST_Human1.15817936
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15722848
62* WT1_19549856_ChIP-ChIP_CCG9911_Human1.13636277
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13542182
64EWS_26573619_Chip-Seq_HEK293_Human1.12422754
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12286459
66* NANOG_21062744_ChIP-ChIP_HESCs_Human1.10628789
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08026205
68* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07747856
69* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07527704
70* FOXP3_21729870_ChIP-Seq_TREG_Human1.06965445
71FUS_26573619_Chip-Seq_HEK293_Human1.06552584
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05777760
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05699999
74* SOX17_20123909_ChIP-Seq_XEN_Mouse1.05516447
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.01928593
76HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00398189
77* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99581852
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99535678
79SOX9_26525672_Chip-Seq_HEART_Mouse0.99290203
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98795754
81* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98401950
82TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98400424
83GATA1_26923725_Chip-Seq_HPCs_Mouse0.98363648
84SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98076748
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97225810
86CLOCK_20551151_ChIP-Seq_293T_Human0.96236090
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96081865
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94708691
89* CHD1_26751641_Chip-Seq_LNCaP_Human0.93040858
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92962994
91NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92079374
92KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90948547
93* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89707660
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89430628
95* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89300753
96* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88576051
97* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88473611
98ETS1_20019798_ChIP-Seq_JURKAT_Human0.87030027
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85267968
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85048914
101TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84867544
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84810410
103SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84764139
104ISL1_27105846_Chip-Seq_CPCs_Mouse0.84761441
105TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84536715
106MYC_18940864_ChIP-ChIP_HL60_Human0.83536081
107DCP1A_22483619_ChIP-Seq_HELA_Human0.82431527
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81853279
109* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81171183
110YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78840307
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77359201
112THAP11_20581084_ChIP-Seq_MESCs_Mouse0.75688076
113* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.74805418
114* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.73839570
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.71910102
116* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.71881481
117* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.71368717
118SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.70399104
119GABP_19822575_ChIP-Seq_HepG2_Human0.70296031

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.92709117
2MP0003111_abnormal_nucleus_morphology3.50690023
3MP0008057_abnormal_DNA_replication3.28866273
4MP0004957_abnormal_blastocyst_morpholog3.26913699
5MP0003693_abnormal_embryo_hatching3.21961651
6MP0003077_abnormal_cell_cycle3.10482320
7MP0003123_paternal_imprinting2.96478350
8MP0010352_gastrointestinal_tract_polyps2.75573215
9MP0003121_genomic_imprinting2.45126638
10MP0010307_abnormal_tumor_latency2.43296646
11MP0003705_abnormal_hypodermis_morpholog2.35288397
12MP0000537_abnormal_urethra_morphology2.30189676
13MP0005076_abnormal_cell_differentiation2.29989363
14MP0009053_abnormal_anal_canal2.28180253
15MP0008932_abnormal_embryonic_tissue2.11753959
16MP0001730_embryonic_growth_arrest2.11632501
17MP0010030_abnormal_orbit_morphology2.10882865
18MP0004197_abnormal_fetal_growth/weight/2.05695792
19MP0000350_abnormal_cell_proliferation2.05260733
20MP0008058_abnormal_DNA_repair2.02788734
21MP0008007_abnormal_cellular_replicative1.99636648
22MP0003890_abnormal_embryonic-extraembry1.98191700
23MP0002084_abnormal_developmental_patter1.95373611
24MP0006292_abnormal_olfactory_placode1.94943142
25MP0001672_abnormal_embryogenesis/_devel1.92350727
26MP0005380_embryogenesis_phenotype1.92350727
27MP0010234_abnormal_vibrissa_follicle1.91520156
28MP0000566_synostosis1.89922583
29MP0003937_abnormal_limbs/digits/tail_de1.83955861
30MP0002085_abnormal_embryonic_tissue1.82561492
31MP0001697_abnormal_embryo_size1.80099938
32MP0001293_anophthalmia1.75467596
33MP0003984_embryonic_growth_retardation1.74276912
34MP0002088_abnormal_embryonic_growth/wei1.73019904
35MP0002086_abnormal_extraembryonic_tissu1.72115031
36MP0003567_abnormal_fetal_cardiomyocyte1.65428308
37MP0008877_abnormal_DNA_methylation1.56441150
38MP0009703_decreased_birth_body1.55284857
39MP0009379_abnormal_foot_pigmentation1.50741811
40MP0002396_abnormal_hematopoietic_system1.47970632
41MP0002080_prenatal_lethality1.44706356
42MP0003787_abnormal_imprinting1.44559810
43MP0000579_abnormal_nail_morphology1.43040984
44MP0003119_abnormal_digestive_system1.41803970
45MP0003136_yellow_coat_color1.36536559
46MP0001346_abnormal_lacrimal_gland1.36093147
47MP0003941_abnormal_skin_development1.35921987
48MP0004808_abnormal_hematopoietic_stem1.34980904
49MP0003385_abnormal_body_wall1.34671741
50MP0003935_abnormal_craniofacial_develop1.34293638
51MP0000569_abnormal_digit_pigmentation1.32114742
52MP0003122_maternal_imprinting1.31101396
53MP0009672_abnormal_birth_weight1.30377816
54MP0003755_abnormal_palate_morphology1.27632122
55MP0000428_abnormal_craniofacial_morphol1.27183196
56MP0006054_spinal_hemorrhage1.27083725
57MP0000516_abnormal_urinary_system1.26931219
58MP0005367_renal/urinary_system_phenotyp1.26931219
59MP0005623_abnormal_meninges_morphology1.25960950
60MP0000432_abnormal_head_morphology1.23802794
61MP0000778_abnormal_nervous_system1.22045652
62MP0000733_abnormal_muscle_development1.19683092
63MP0002009_preneoplasia1.19222746
64MP0002697_abnormal_eye_size1.17119592
65MP0001286_abnormal_eye_development1.15707007
66MP0003115_abnormal_respiratory_system1.15584236
67MP0002111_abnormal_tail_morphology1.13743348
68MP0002092_abnormal_eye_morphology1.13326165
69MP0010678_abnormal_skin_adnexa1.12610583
70MP0004185_abnormal_adipocyte_glucose1.10340462
71MP0005187_abnormal_penis_morphology1.08175272
72MP0003315_abnormal_perineum_morphology1.07575892
73MP0003861_abnormal_nervous_system1.06411047
74MP0001177_atelectasis1.04668176
75MP0002938_white_spotting1.03685366
76MP0002932_abnormal_joint_morphology1.00962256
77MP0009697_abnormal_copulation0.99556957
78MP0001188_hyperpigmentation0.98878394
79MP0003942_abnormal_urinary_system0.97053343
80MP0009250_abnormal_appendicular_skeleto0.95928505
81MP0002282_abnormal_trachea_morphology0.95310818
82MP0004272_abnormal_basement_membrane0.93835974
83MP0002925_abnormal_cardiovascular_devel0.93698232
84MP0002233_abnormal_nose_morphology0.93316537
85MP0000313_abnormal_cell_death0.92548722
86MP0001915_intracranial_hemorrhage0.89560511
87MP0000383_abnormal_hair_follicle0.89297232
88MP0003786_premature_aging0.88974958
89MP0002114_abnormal_axial_skeleton0.87882937
90MP0000049_abnormal_middle_ear0.87786886
91MP0002116_abnormal_craniofacial_bone0.84884152
92MP0000490_abnormal_crypts_of0.84542864
93MP0002249_abnormal_larynx_morphology0.84500522
94MP0001849_ear_inflammation0.84439397
95MP0002234_abnormal_pharynx_morphology0.83843247
96MP0002081_perinatal_lethality0.83583548
97MP0002019_abnormal_tumor_incidence0.83569659
98MP0003566_abnormal_cell_adhesion0.82860363
99MP0002184_abnormal_innervation0.80901555
100MP0009780_abnormal_chondrocyte_physiolo0.80801391
101MP0002152_abnormal_brain_morphology0.80478898
102MP0005248_abnormal_Harderian_gland0.78793364
103MP0002109_abnormal_limb_morphology0.78118324
104MP0002751_abnormal_autonomic_nervous0.78115168
105MP0000762_abnormal_tongue_morphology0.77891033
106MP0000462_abnormal_digestive_system0.77856260
107MP0000534_abnormal_ureter_morphology0.73913162
108MP0004859_abnormal_synaptic_plasticity0.73848531
109MP0000955_abnormal_spinal_cord0.73778280
110MP0003938_abnormal_ear_development0.73226083
111MP0000427_abnormal_hair_cycle0.72837192
112MP0002877_abnormal_melanocyte_morpholog0.72423971
113MP0005257_abnormal_intraocular_pressure0.71124045
114MP0004233_abnormal_muscle_weight0.70535686
115MP0004133_heterotaxia0.69104319
116MP0008770_decreased_survivor_rate0.69055684
117MP0005391_vision/eye_phenotype0.68529685
118MP0010630_abnormal_cardiac_muscle0.68134184
119MP0001299_abnormal_eye_distance/0.68119140
120MP0003283_abnormal_digestive_organ0.67527137
121MP0002177_abnormal_outer_ear0.67122366
122MP0001340_abnormal_eyelid_morphology0.66030149
123MP0004270_analgesia0.65282028
124MP0000647_abnormal_sebaceous_gland0.64411833
125MP0000631_abnormal_neuroendocrine_gland0.63620711

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.12994734
2Short 4th metacarpal (HP:0010044)3.76552414
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.76552414
4Medulloblastoma (HP:0002885)3.18936014
5Colon cancer (HP:0003003)3.18910877
6Cortical dysplasia (HP:0002539)3.15069020
7Chromsome breakage (HP:0040012)3.07674910
8Ependymoma (HP:0002888)3.02698577
9Abnormality of the labia minora (HP:0012880)2.98440693
10Rhabdomyosarcoma (HP:0002859)2.96244450
11Increased nuchal translucency (HP:0010880)2.92028431
12Abnormality of the 4th metacarpal (HP:0010012)2.74249348
13Abnormality of chromosome stability (HP:0003220)2.74224419
14Abnormality of the astrocytes (HP:0100707)2.69889261
15Astrocytoma (HP:0009592)2.69889261
16Deviation of the thumb (HP:0009603)2.67344137
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64620313
18Proximal placement of thumb (HP:0009623)2.63202399
19Glioma (HP:0009733)2.44865987
20Deep philtrum (HP:0002002)2.38163891
21Neoplasm of the oral cavity (HP:0100649)2.37825344
22High anterior hairline (HP:0009890)2.35635491
23Atresia of the external auditory canal (HP:0000413)2.35625445
24Biliary tract neoplasm (HP:0100574)2.33560504
25Nephroblastoma (Wilms tumor) (HP:0002667)2.33087609
26Neoplasm of striated muscle (HP:0009728)2.31862443
27Ectopic kidney (HP:0000086)2.31259775
28Duplication of thumb phalanx (HP:0009942)2.29608929
29Gastrointestinal carcinoma (HP:0002672)2.28155179
30Malignant gastrointestinal tract tumors (HP:0006749)2.28155179
31Asymmetry of the thorax (HP:0001555)2.26672526
32Selective tooth agenesis (HP:0001592)2.25137100
33Abnormal lung lobation (HP:0002101)2.24877857
34Embryonal renal neoplasm (HP:0011794)2.24408692
35Meckel diverticulum (HP:0002245)2.21700204
36Cutaneous melanoma (HP:0012056)2.19399336
37Abnormal number of incisors (HP:0011064)2.18435546
38Facial hemangioma (HP:0000329)2.16451194
39Coronal craniosynostosis (HP:0004440)2.16306373
40Overriding aorta (HP:0002623)2.16078232
41Impulsivity (HP:0100710)2.13941866
42Small intestinal stenosis (HP:0012848)2.11030838
43Duodenal stenosis (HP:0100867)2.11030838
44Renal duplication (HP:0000075)2.10344271
45Agnosia (HP:0010524)2.09817840
46Abnormality of the ileum (HP:0001549)2.08957609
47Hepatoblastoma (HP:0002884)2.08087544
48Basal cell carcinoma (HP:0002671)2.07866697
49Supernumerary ribs (HP:0005815)2.06715317
50Septo-optic dysplasia (HP:0100842)2.05174634
51Aplasia/Hypoplasia of the sternum (HP:0006714)2.04965868
52Skull defect (HP:0001362)2.04282741
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.00617601
54Ankyloglossia (HP:0010296)2.00354286
55Long eyelashes (HP:0000527)2.00285121
56Partial duplication of thumb phalanx (HP:0009944)2.00222441
57Hyperacusis (HP:0010780)1.99057192
58Spastic diplegia (HP:0001264)1.97644251
59Missing ribs (HP:0000921)1.96977445
60Broad thumb (HP:0011304)1.95954376
61Subacute progressive viral hepatitis (HP:0006572)1.95802042
62Birth length less than 3rd percentile (HP:0003561)1.95649058
63Esophageal atresia (HP:0002032)1.95189758
64Cafe-au-lait spot (HP:0000957)1.93175555
65Abnormality of the preputium (HP:0100587)1.92787312
66Multiple enchondromatosis (HP:0005701)1.92735559
67Supernumerary bones of the axial skeleton (HP:0009144)1.92376307
68Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.92114974
69Partial duplication of the phalanx of hand (HP:0009999)1.90404061
70Patellar aplasia (HP:0006443)1.89769689
71Reticulocytopenia (HP:0001896)1.88743492
72Absent radius (HP:0003974)1.87890488
73Cutaneous syndactyly (HP:0012725)1.87885635
74Aplasia involving bones of the extremities (HP:0009825)1.87500532
75Aplasia involving bones of the upper limbs (HP:0009823)1.87500532
76Aplasia of the phalanges of the hand (HP:0009802)1.87500532
77Truncal obesity (HP:0001956)1.86997489
78Abnormality of the distal phalanx of the thumb (HP:0009617)1.85236315
79Uterine neoplasm (HP:0010784)1.85131325
80Obsessive-compulsive behavior (HP:0000722)1.84394604
81Overlapping toe (HP:0001845)1.84321552
82Myelodysplasia (HP:0002863)1.83972624
83Cutaneous finger syndactyly (HP:0010554)1.83463616
84Ovarian neoplasm (HP:0100615)1.83414352
85Insomnia (HP:0100785)1.82771303
86Abnormality of the duodenum (HP:0002246)1.81536154
87Aplasia/Hypoplasia of the patella (HP:0006498)1.81384028
88Abnormality of the septum pellucidum (HP:0007375)1.80783016
89Abnormality of abdominal situs (HP:0011620)1.80227868
90Abdominal situs inversus (HP:0003363)1.80227868
91Shallow orbits (HP:0000586)1.78614209
92Macroorchidism (HP:0000053)1.78350218
93High pitched voice (HP:0001620)1.77632590
94Abnormality of the calcaneus (HP:0008364)1.77624731
95Omphalocele (HP:0001539)1.77347669
96Turricephaly (HP:0000262)1.77082058
97Absent frontal sinuses (HP:0002688)1.76850041
98Transitional cell carcinoma of the bladder (HP:0006740)1.76201107
99Cutis marmorata (HP:0000965)1.75969600
100Intestinal polyposis (HP:0200008)1.75899045
101Urethral obstruction (HP:0000796)1.75025748
102Syringomyelia (HP:0003396)1.75009453
103Spinal cord lesions (HP:0100561)1.75009453
104Papillary thyroid carcinoma (HP:0002895)1.74923921
105Elfin facies (HP:0004428)1.74823195
106Heterotopia (HP:0002282)1.73802844
107Sandal gap (HP:0001852)1.73630540
108Increased number of teeth (HP:0011069)1.73514971
109Abnormality of the phalanges of the hallux (HP:0010057)1.73389297
110Vertebral clefting (HP:0008428)1.72676324
111Abnormality of chromosome segregation (HP:0002916)1.72541689
112Aplasia involving forearm bones (HP:0009822)1.72519988
113Absent forearm bone (HP:0003953)1.72519988
114Intestinal polyp (HP:0005266)1.72346665
115Pelvic girdle muscle weakness (HP:0003749)1.71031972
116Short humerus (HP:0005792)1.70997902
117Rib fusion (HP:0000902)1.70608499
118Prominent nose (HP:0000448)1.70385445
119Renovascular hypertension (HP:0100817)1.70012800
120Benign neoplasm of the central nervous system (HP:0100835)1.69322089
121Abnormality of the carotid arteries (HP:0005344)1.69292667
122Trigonocephaly (HP:0000243)1.68799615
123Vertebral arch anomaly (HP:0008438)1.68689921
124Abnormality of the fingertips (HP:0001211)1.68654021
125Arnold-Chiari malformation (HP:0002308)1.68094702
126Hypoplasia of the maxilla (HP:0000327)1.67541321
127Facial cleft (HP:0002006)1.67401665
128Broad phalanges of the hand (HP:0009768)1.67291739
129Abnormality of the parietal bone (HP:0002696)1.67208234
130Bladder neoplasm (HP:0009725)1.67194819
131Bladder carcinoma (HP:0002862)1.67194819
132Aplasia/hypoplasia of the humerus (HP:0006507)1.67137229
133Supernumerary spleens (HP:0009799)1.66803757
134Uterine leiomyosarcoma (HP:0002891)1.66799933
135Leiomyosarcoma (HP:0100243)1.66799933
136Embryonal neoplasm (HP:0002898)1.65118280
137Termporal pattern (HP:0011008)1.64493290
138Insidious onset (HP:0003587)1.64493290
139Choanal stenosis (HP:0000452)1.61564844
140Abnormality of the lacrimal duct (HP:0011481)1.59069767
141Cystic hygroma (HP:0000476)1.57386213
142Partial agenesis of the corpus callosum (HP:0001338)1.55833889
143Triphalangeal thumb (HP:0001199)1.55601359
144Bilateral microphthalmos (HP:0007633)1.55486854
145Abnormality of cochlea (HP:0000375)1.55080934
146Absent septum pellucidum (HP:0001331)1.52443966
147Maternal diabetes (HP:0009800)1.51556752
148Radioulnar synostosis (HP:0002974)1.51205657
149Microglossia (HP:0000171)1.50620338
150Abnormality of the nasolacrimal system (HP:0000614)1.49746285
151Absent eyebrow (HP:0002223)1.49421742
152Myelomeningocele (HP:0002475)1.49141985
153Choanal atresia (HP:0000453)1.48044788
154Aplasia/Hypoplasia of the sacrum (HP:0008517)1.47536658

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.88093145
2CDK123.37571391
3WEE13.00931412
4SRPK12.98234202
5NEK22.88141317
6NEK12.63799375
7TLK12.61747487
8MKNK12.58810378
9TTK2.29866845
10PLK32.27934997
11MKNK22.08948724
12TAF12.06236985
13PBK2.00080705
14BUB11.99765555
15PKN21.94350751
16BRSK21.91239774
17CDK61.86593382
18EEF2K1.81761241
19SCYL21.79201535
20PLK11.78706236
21CHEK21.76465390
22AURKB1.74919561
23LATS11.74120866
24TSSK61.73716020
25ATR1.67851769
26FRK1.57983607
27CDK41.57764382
28RPS6KB21.55373441
29ZAK1.51452156
30STK41.51304817
31BRD41.51039610
32CHEK11.43282923
33MAP3K101.40788674
34PASK1.38202467
35ATM1.33779097
36SMG11.33330915
37CDK71.30285236
38PNCK1.28853649
39CASK1.27738381
40MAP3K81.27703649
41ALK1.26298862
42STK31.25948827
43EIF2AK11.24055953
44VRK21.20728275
45MAP3K91.20239970
46NTRK11.16911063
47FGFR21.16110112
48MELK1.14917060
49STK38L1.14565233
50CAMK1G1.11653643
51ICK1.09825571
52STK101.08749491
53* CDK21.06363257
54VRK11.05254244
55ACVR1B1.04400878
56BRSK11.03206833
57TNIK1.02305787
58* CDK10.91619128
59FGFR10.89251908
60TGFBR10.88156966
61RPS6KA40.85914814
62DYRK30.85615008
63MTOR0.84940487
64TYRO30.84070934
65EPHA20.82709501
66PLK40.81068167
67AURKA0.80974087
68ERBB30.79434502
69CSNK1D0.76571996
70AKT30.76402497
71BRAF0.75930679
72KSR10.72932017
73CDK150.71644334
74ERBB40.71402361
75CDK180.70130334
76UHMK10.69696366
77EPHA40.67714432
78PRKDC0.67289184
79CDK11A0.66561305
80CSNK1E0.66296927
81TTN0.66276713
82PDGFRA0.65716170
83PIM10.65558649
84MINK10.65456157
85CCNB10.64712685
86PLK20.64164467
87CDK140.63233888
88CDK90.62620179
89PAK40.61610900
90LATS20.61563377
91MAPK140.57557630
92CDK30.57379539
93MET0.57060286
94CSNK2A20.55363600
95NUAK10.53841754
96LRRK20.53503694
97CAMK1D0.53178618
98PTK60.52080615
99DYRK20.51273145
100PTK20.50568455
101NTRK20.49994463
102FGFR30.49102212
103RPS6KA50.48082262
104BCR0.47392652
105EIF2AK20.46889981
106RPS6KB10.46721420
107WNK30.46528044
108YES10.44955874
109PAK20.44501755
110MARK10.43933967
111NEK90.43671607
112MAP3K40.43530106
113CLK10.42028708
114TRIB30.41532801
115AKT10.41249506
116AKT20.41169165
117GSK3B0.40136438
118STK240.38865995
119CSNK2A10.36250268
120BMX0.36157688
121EIF2AK30.35895213
122MAPK100.34911716
123DMPK0.34729720
124MARK30.34527228
125TESK20.33713575
126CSNK1G10.33551503
127CSNK1A1L0.32232976
128MAPK10.31180644
129FLT30.29101851
130ILK0.28912166
131PDGFRB0.28379388

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.79572084
2Mismatch repair_Homo sapiens_hsa034303.66831390
3Cell cycle_Homo sapiens_hsa041103.25616457
4Systemic lupus erythematosus_Homo sapiens_hsa053223.07792347
5RNA transport_Homo sapiens_hsa030133.00897606
6Spliceosome_Homo sapiens_hsa030402.93400862
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85636202
8One carbon pool by folate_Homo sapiens_hsa006702.55059534
9mRNA surveillance pathway_Homo sapiens_hsa030152.43679902
10Non-homologous end-joining_Homo sapiens_hsa034502.35674245
11Nucleotide excision repair_Homo sapiens_hsa034202.35196782
12Homologous recombination_Homo sapiens_hsa034402.35177621
13Fanconi anemia pathway_Homo sapiens_hsa034602.34478364
14Base excision repair_Homo sapiens_hsa034102.23368140
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.22042684
16Alcoholism_Homo sapiens_hsa050341.86869637
17MicroRNAs in cancer_Homo sapiens_hsa052061.80307117
18RNA degradation_Homo sapiens_hsa030181.73479231
19Viral carcinogenesis_Homo sapiens_hsa052031.72081074
20Oocyte meiosis_Homo sapiens_hsa041141.70869917
21p53 signaling pathway_Homo sapiens_hsa041151.65387443
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.61424312
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.59284555
24Basal cell carcinoma_Homo sapiens_hsa052171.45327861
25Hippo signaling pathway_Homo sapiens_hsa043901.39023947
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35395679
27Colorectal cancer_Homo sapiens_hsa052101.31162785
28Adherens junction_Homo sapiens_hsa045201.29768814
29TGF-beta signaling pathway_Homo sapiens_hsa043501.21655271
30Small cell lung cancer_Homo sapiens_hsa052221.21419774
31Ribosome_Homo sapiens_hsa030101.20714093
32Thyroid cancer_Homo sapiens_hsa052161.20645683
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17991527
34HTLV-I infection_Homo sapiens_hsa051661.17277260
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17093105
36Biosynthesis of amino acids_Homo sapiens_hsa012301.16955506
37Chronic myeloid leukemia_Homo sapiens_hsa052201.09535407
38Basal transcription factors_Homo sapiens_hsa030221.09357562
39mTOR signaling pathway_Homo sapiens_hsa041501.06763200
40Vitamin B6 metabolism_Homo sapiens_hsa007501.06689800
41Hedgehog signaling pathway_Homo sapiens_hsa043401.05610515
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04154059
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03653307
44Prostate cancer_Homo sapiens_hsa052151.03257250
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.01337772
46Endometrial cancer_Homo sapiens_hsa052131.00712334
47Pyruvate metabolism_Homo sapiens_hsa006200.98601739
48Wnt signaling pathway_Homo sapiens_hsa043100.98187236
49Non-small cell lung cancer_Homo sapiens_hsa052230.96603542
50Proteoglycans in cancer_Homo sapiens_hsa052050.95528506
51RNA polymerase_Homo sapiens_hsa030200.94645745
52Lysine degradation_Homo sapiens_hsa003100.91035942
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90331210
54Epstein-Barr virus infection_Homo sapiens_hsa051690.87258777
55Glioma_Homo sapiens_hsa052140.87188698
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85518525
57Pyrimidine metabolism_Homo sapiens_hsa002400.85431457
58Melanoma_Homo sapiens_hsa052180.82702970
59Tight junction_Homo sapiens_hsa045300.79406015
60Pathways in cancer_Homo sapiens_hsa052000.79119795
61Antigen processing and presentation_Homo sapiens_hsa046120.79071177
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76371929
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.73552240
64Herpes simplex infection_Homo sapiens_hsa051680.72584346
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71313629
66Carbon metabolism_Homo sapiens_hsa012000.71061316
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70216068
68Bladder cancer_Homo sapiens_hsa052190.69406069
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69068636
70Pancreatic cancer_Homo sapiens_hsa052120.68648798
71Viral myocarditis_Homo sapiens_hsa054160.68039250
72Hepatitis B_Homo sapiens_hsa051610.67949732
73FoxO signaling pathway_Homo sapiens_hsa040680.66331164
74Focal adhesion_Homo sapiens_hsa045100.66090536
75Dilated cardiomyopathy_Homo sapiens_hsa054140.62801216
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62217721
77Steroid biosynthesis_Homo sapiens_hsa001000.60864030
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60401107
79Melanogenesis_Homo sapiens_hsa049160.57732150
80Renal cell carcinoma_Homo sapiens_hsa052110.53948339
81Notch signaling pathway_Homo sapiens_hsa043300.53818410
82Selenocompound metabolism_Homo sapiens_hsa004500.52015899
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52006137
84Folate biosynthesis_Homo sapiens_hsa007900.51599006
85Thyroid hormone synthesis_Homo sapiens_hsa049180.50199852
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50195022
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50145637
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49945007
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.49335472
90Nicotine addiction_Homo sapiens_hsa050330.48822195
91Cardiac muscle contraction_Homo sapiens_hsa042600.48449887
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46576986
93Estrogen signaling pathway_Homo sapiens_hsa049150.44973801
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44669008
95ECM-receptor interaction_Homo sapiens_hsa045120.44079940
96HIF-1 signaling pathway_Homo sapiens_hsa040660.43545432
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43446025
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42422561
99ErbB signaling pathway_Homo sapiens_hsa040120.41967654
100Long-term potentiation_Homo sapiens_hsa047200.40567986
101Axon guidance_Homo sapiens_hsa043600.39187706
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39162150
103Rap1 signaling pathway_Homo sapiens_hsa040150.39006408
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.36873351
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35931145
106Choline metabolism in cancer_Homo sapiens_hsa052310.35925254
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35155618
108AMPK signaling pathway_Homo sapiens_hsa041520.34932369
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33867377
110Platelet activation_Homo sapiens_hsa046110.33454393
111Gap junction_Homo sapiens_hsa045400.32089727
112Apoptosis_Homo sapiens_hsa042100.31846558
113Purine metabolism_Homo sapiens_hsa002300.31454572
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31308015
115Acute myeloid leukemia_Homo sapiens_hsa052210.29944218
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26400283
117MAPK signaling pathway_Homo sapiens_hsa040100.25076051
118VEGF signaling pathway_Homo sapiens_hsa043700.25025620
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24576907
120Proteasome_Homo sapiens_hsa030500.23032976
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23032119
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21578650
123Dorso-ventral axis formation_Homo sapiens_hsa043200.21428629
124Glucagon signaling pathway_Homo sapiens_hsa049220.21267699
125Insulin signaling pathway_Homo sapiens_hsa049100.21145883
126B cell receptor signaling pathway_Homo sapiens_hsa046620.18119334
127Shigellosis_Homo sapiens_hsa051310.17349798

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