NUDC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.20157128
2DNA strand elongation involved in DNA replication (GO:0006271)5.00844415
3DNA replication initiation (GO:0006270)4.84254234
4protein maturation by protein folding (GO:0022417)4.76536882
5DNA strand elongation (GO:0022616)4.73394359
6formation of translation preinitiation complex (GO:0001731)4.65704292
7DNA deamination (GO:0045006)4.61571067
8regulation of mitochondrial translation (GO:0070129)4.55995950
9telomere maintenance via semi-conservative replication (GO:0032201)4.54954884
10folic acid-containing compound biosynthetic process (GO:0009396)4.41413647
11protein localization to kinetochore (GO:0034501)4.40768178
12maturation of SSU-rRNA (GO:0030490)4.32910913
13nucleobase biosynthetic process (GO:0046112)4.32187541
14establishment of viral latency (GO:0019043)4.28880911
15DNA replication-dependent nucleosome assembly (GO:0006335)4.13662920
16DNA replication-dependent nucleosome organization (GO:0034723)4.13662920
17ribosomal small subunit assembly (GO:0000028)4.09056001
18DNA replication checkpoint (GO:0000076)4.07140850
19mitotic nuclear envelope disassembly (GO:0007077)4.00856494
20IMP biosynthetic process (GO:0006188)3.98811050
21ribosome biogenesis (GO:0042254)3.92841657
22telomere maintenance via recombination (GO:0000722)3.90617290
23purine nucleobase biosynthetic process (GO:0009113)3.89466084
24viral transcription (GO:0019083)3.85888503
25proteasome assembly (GO:0043248)3.83625431
26ribosome assembly (GO:0042255)3.83255856
27mitotic metaphase plate congression (GO:0007080)3.82535420
28translational termination (GO:0006415)3.81806925
29chaperone-mediated protein transport (GO:0072321)3.73942548
30membrane disassembly (GO:0030397)3.73856483
31nuclear envelope disassembly (GO:0051081)3.73856483
32protein localization to chromosome, centromeric region (GO:0071459)3.71755684
33telomere maintenance via telomere lengthening (GO:0010833)3.71629800
34mitotic recombination (GO:0006312)3.71568093
35pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.69538507
36nucleobase-containing small molecule interconversion (GO:0015949)3.65549590
37translational elongation (GO:0006414)3.65253289
38negative regulation of ligase activity (GO:0051352)3.64276462
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.64276462
40translational initiation (GO:0006413)3.63651381
41ribonucleoprotein complex biogenesis (GO:0022613)3.62890189
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.62401576
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.60281875
44nuclear envelope reassembly (GO:0031468)3.58843634
45mitotic nuclear envelope reassembly (GO:0007084)3.58843634
46proline biosynthetic process (GO:0006561)3.58080048
47IMP metabolic process (GO:0046040)3.57768892
48regulation of cellular amino acid metabolic process (GO:0006521)3.52337186
49nuclear pore organization (GO:0006999)3.52220390
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.50848300
51regulation of translational termination (GO:0006449)3.48489643
52spliceosomal snRNP assembly (GO:0000387)3.46016337
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.45624146
54mitotic sister chromatid segregation (GO:0000070)3.45243389
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44035107
56Golgi transport vesicle coating (GO:0048200)3.43193808
57COPI coating of Golgi vesicle (GO:0048205)3.43193808
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.41855472
59pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.40946384
60ribosomal small subunit biogenesis (GO:0042274)3.40831066
61chromatin remodeling at centromere (GO:0031055)3.40243735
62oxidative phosphorylation (GO:0006119)3.38937274
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.38471566
64ribosomal large subunit biogenesis (GO:0042273)3.38463868
65DNA duplex unwinding (GO:0032508)3.38424072
66DNA geometric change (GO:0032392)3.37090054
67protein targeting to mitochondrion (GO:0006626)3.34803133
68metaphase plate congression (GO:0051310)3.34408779
69regulation of posttranscriptional gene silencing (GO:0060147)3.34360545
70regulation of gene silencing by miRNA (GO:0060964)3.34360545
71regulation of gene silencing by RNA (GO:0060966)3.34360545
72establishment of integrated proviral latency (GO:0075713)3.31870980
73CENP-A containing nucleosome assembly (GO:0034080)3.31722559
74rRNA processing (GO:0006364)3.28744229
75positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27544190
76mitotic chromosome condensation (GO:0007076)3.26188285
77negative regulation of mRNA processing (GO:0050686)3.23216693
78DNA replication-independent nucleosome assembly (GO:0006336)3.22540903
79DNA replication-independent nucleosome organization (GO:0034724)3.22540903
80protein complex localization (GO:0031503)3.21619015
81pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.21102631
82nuclear pore complex assembly (GO:0051292)3.20567703
83peptidyl-arginine omega-N-methylation (GO:0035247)3.18954715
84rRNA metabolic process (GO:0016072)3.17892596
85heterochromatin organization (GO:0070828)3.16230796
86pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.15205978
87SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14967023
882-deoxyribonucleotide biosynthetic process (GO:0009265)3.14257253
89deoxyribose phosphate biosynthetic process (GO:0046385)3.14257253
90pseudouridine synthesis (GO:0001522)3.13778232
91negative regulation of RNA splicing (GO:0033119)3.12843108
92regulation of translational fidelity (GO:0006450)3.10976019
93somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10940891
94somatic hypermutation of immunoglobulin genes (GO:0016446)3.10940891
95positive regulation of ligase activity (GO:0051351)3.10744773
96establishment of protein localization to mitochondrion (GO:0072655)3.09894132
97DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07967167
98deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.07600214
99folic acid metabolic process (GO:0046655)3.07287703
100guanosine-containing compound biosynthetic process (GO:1901070)3.07124801
101transcription-coupled nucleotide-excision repair (GO:0006283)3.06970639
102intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06231005
103signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06231005
104sister chromatid segregation (GO:0000819)3.06165294
105signal transduction involved in DNA integrity checkpoint (GO:0072401)3.05291758
106signal transduction involved in DNA damage checkpoint (GO:0072422)3.05291758
107regulation of ubiquitin-protein transferase activity (GO:0051438)3.05156022
108regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04813400
109protein targeting to ER (GO:0045047)3.04765845
110cellular protein complex disassembly (GO:0043624)3.04396487
111signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.04158532
112signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.04158532
113signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.04158532
114cotranslational protein targeting to membrane (GO:0006613)3.04089070
115viral mRNA export from host cell nucleus (GO:0046784)3.03740169
116negative regulation of chromosome segregation (GO:0051985)3.03012947
117cellular component biogenesis (GO:0044085)3.02727260
118histone arginine methylation (GO:0034969)3.02326000
119de novo protein folding (GO:0006458)3.02226205
120viral life cycle (GO:0019058)3.02169458
121establishment of chromosome localization (GO:0051303)3.01947267
122establishment of protein localization to mitochondrial membrane (GO:0090151)3.01852738
123base-excision repair (GO:0006284)3.01649712
124RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.01359012
125mRNA splicing, via spliceosome (GO:0000398)3.01359012
126deoxyribonucleotide biosynthetic process (GO:0009263)3.00875907
127RNA splicing, via transesterification reactions (GO:0000375)3.00529504
128spliceosomal tri-snRNP complex assembly (GO:0000244)3.00525831
129anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.00312360
130protein localization to mitochondrion (GO:0070585)3.00300489
131GDP-mannose metabolic process (GO:0019673)2.99922102
132kinetochore organization (GO:0051383)2.99070347
133tRNA aminoacylation for protein translation (GO:0006418)2.98215650
134signal transduction involved in cell cycle checkpoint (GO:0072395)2.97525824
135pyrimidine nucleotide catabolic process (GO:0006244)2.96679397
136negative regulation of mitotic sister chromatid separation (GO:2000816)2.96117225
137negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96117225
138negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96117225
139negative regulation of sister chromatid segregation (GO:0033046)2.96117225
140transcription from mitochondrial promoter (GO:0006390)2.96021979
141spliceosomal complex assembly (GO:0000245)2.95815259
142regulation of spindle organization (GO:0090224)2.94517138
143metallo-sulfur cluster assembly (GO:0031163)2.93320566
144iron-sulfur cluster assembly (GO:0016226)2.93320566
145negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92990492
146mitotic G1 DNA damage checkpoint (GO:0031571)2.92902575
147de novo posttranslational protein folding (GO:0051084)2.92717629
148mitotic spindle assembly checkpoint (GO:0007094)2.92183317
149regulation of ligase activity (GO:0051340)2.91914843
150rRNA transcription (GO:0009303)2.91439452
151postreplication repair (GO:0006301)2.91250752
152nuclear envelope organization (GO:0006998)2.90941820
153histone exchange (GO:0043486)2.90905318
154chromatin assembly or disassembly (GO:0006333)2.90638124
155pteridine-containing compound biosynthetic process (GO:0042559)2.89977800
156protein complex disassembly (GO:0043241)2.89620950
157translesion synthesis (GO:0019985)2.89560129
158spindle assembly checkpoint (GO:0071173)2.89476517
159amino acid activation (GO:0043038)2.88010482
160tRNA aminoacylation (GO:0043039)2.88010482
161transcription elongation from RNA polymerase III promoter (GO:0006385)2.86984224
162termination of RNA polymerase III transcription (GO:0006386)2.86984224
163UTP biosynthetic process (GO:0006228)2.86398553
164energy coupled proton transport, down electrochemical gradient (GO:0015985)2.86100415
165ATP synthesis coupled proton transport (GO:0015986)2.86100415

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.75990588
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.32602120
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.11528512
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.78434539
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20055385
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.08822333
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86421265
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84831593
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79823103
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.61864625
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.54190835
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51442832
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46895260
14XRN2_22483619_ChIP-Seq_HELA_Human2.44145787
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.34468966
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31558100
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31228399
18* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28616584
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04909786
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04865363
21AR_21909140_ChIP-Seq_LNCAP_Human1.99102357
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98987432
23MYC_22102868_ChIP-Seq_BL_Human1.98828757
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93988662
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.90933598
26VDR_23849224_ChIP-Seq_CD4+_Human1.90569741
27GABP_19822575_ChIP-Seq_HepG2_Human1.86648083
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.86286713
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85237117
30DCP1A_22483619_ChIP-Seq_HELA_Human1.84177294
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78662499
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77082542
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76889089
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75096587
35TTF2_22483619_ChIP-Seq_HELA_Human1.74047414
36* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72787706
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72328326
38FOXP3_21729870_ChIP-Seq_TREG_Human1.71287093
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66521661
40CIITA_25753668_ChIP-Seq_RAJI_Human1.64674765
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58241646
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56680757
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55269286
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54042011
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51503914
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51026560
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.49621917
48* KDM5A_27292631_Chip-Seq_BREAST_Human1.46681498
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45355058
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41624266
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41114198
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40219345
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39757228
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38400972
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37580875
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34568000
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34290063
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33698068
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.28159257
60VDR_21846776_ChIP-Seq_THP-1_Human1.27774650
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26452843
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24727956
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24429418
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20988843
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20278488
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18043884
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17767693
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16799150
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15186519
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.13884207
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13709368
72TFEB_21752829_ChIP-Seq_HELA_Human1.13476267
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13392946
74CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13146360
75* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12652302
76ELK1_19687146_ChIP-ChIP_HELA_Human1.10804581
77P68_20966046_ChIP-Seq_HELA_Human1.10633183
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10079017
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08531162
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07804321
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07363802
82TBX5_21415370_ChIP-Seq_HL-1_Mouse1.07043737
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.06982463
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04434094
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04329910
86* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03763546
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03522490
88ZNF263_19887448_ChIP-Seq_K562_Human1.03177746
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02564242
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02362617
91CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01965729
92ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01725717
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00463374
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00463374
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00463374
96OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00375576
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99913915
98LXR_22292898_ChIP-Seq_THP-1_Human0.99405346
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98778123
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98102327
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96602938
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96414477
103TP63_19390658_ChIP-ChIP_HaCaT_Human0.96106960
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94708800
105NANOG_21062744_ChIP-ChIP_HESCs_Human0.94113658
106SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93199511
107* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92460729
108E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91390420
109* ELK3_25401928_ChIP-Seq_HUVEC_Human0.91079584
110TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89759011
111PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89547826
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88713738
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88253158
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87658370
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87393226
116NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86999711
117FOXP1_21924763_ChIP-Seq_HESCs_Human0.86822330
118PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86654947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.59255477
2MP0004957_abnormal_blastocyst_morpholog4.78087966
3MP0003111_abnormal_nucleus_morphology4.58612525
4MP0010094_abnormal_chromosome_stability4.51130226
5MP0003077_abnormal_cell_cycle4.08463368
6MP0008057_abnormal_DNA_replication3.31958046
7MP0008058_abnormal_DNA_repair2.98118273
8MP0003123_paternal_imprinting2.95615831
9MP0001730_embryonic_growth_arrest2.79679577
10MP0010352_gastrointestinal_tract_polyps2.77760385
11MP0008007_abnormal_cellular_replicative2.74121353
12MP0008932_abnormal_embryonic_tissue2.71873360
13MP0000350_abnormal_cell_proliferation2.43434180
14MP0008877_abnormal_DNA_methylation2.39263824
15MP0002877_abnormal_melanocyte_morpholog2.26288257
16MP0003806_abnormal_nucleotide_metabolis2.05439795
17MP0005451_abnormal_body_composition2.04424846
18MP0001697_abnormal_embryo_size2.01382372
19MP0002396_abnormal_hematopoietic_system2.01380521
20MP0001672_abnormal_embryogenesis/_devel2.00551353
21MP0005380_embryogenesis_phenotype2.00551353
22MP0002653_abnormal_ependyma_morphology1.93498332
23MP0002080_prenatal_lethality1.89183311
24MP0010030_abnormal_orbit_morphology1.82809722
25MP0002085_abnormal_embryonic_tissue1.82131460
26MP0003984_embryonic_growth_retardation1.81386431
27MP0003786_premature_aging1.80925454
28MP0002084_abnormal_developmental_patter1.80288949
29MP0010307_abnormal_tumor_latency1.79343912
30MP0002088_abnormal_embryonic_growth/wei1.77346936
31MP0008789_abnormal_olfactory_epithelium1.66804085
32MP0000490_abnormal_crypts_of1.63284155
33MP0004197_abnormal_fetal_growth/weight/1.63215863
34MP0002086_abnormal_extraembryonic_tissu1.61228328
35MP0000313_abnormal_cell_death1.59690096
36MP0009697_abnormal_copulation1.52108596
37MP0008875_abnormal_xenobiotic_pharmacok1.51404386
38MP0000678_abnormal_parathyroid_gland1.51102898
39MP0003567_abnormal_fetal_cardiomyocyte1.47336280
40MP0002019_abnormal_tumor_incidence1.46444133
41MP0003718_maternal_effect1.45889493
42MP0000537_abnormal_urethra_morphology1.43533459
43MP0003705_abnormal_hypodermis_morpholog1.41138622
44MP0003119_abnormal_digestive_system1.40509220
45MP0004133_heterotaxia1.38598370
46MP0005501_abnormal_skin_physiology1.36231692
47MP0005076_abnormal_cell_differentiation1.35363051
48MP0005670_abnormal_white_adipose1.35335085
49MP0008260_abnormal_autophagy1.34566027
50MP0004808_abnormal_hematopoietic_stem1.31900135
51MP0005394_taste/olfaction_phenotype1.31540123
52MP0005499_abnormal_olfactory_system1.31540123
53MP0003890_abnormal_embryonic-extraembry1.31169224
54MP0003121_genomic_imprinting1.31005306
55MP0005623_abnormal_meninges_morphology1.29988227
56MP0002210_abnormal_sex_determination1.28283883
57MP0003283_abnormal_digestive_organ1.23476454
58MP0005397_hematopoietic_system_phenotyp1.22816105
59MP0001545_abnormal_hematopoietic_system1.22816105
60MP0000358_abnormal_cell_content/1.22660349
61MP0001293_anophthalmia1.20927304
62MP0001145_abnormal_male_reproductive1.19600581
63MP0001727_abnormal_embryo_implantation1.17983132
64MP0002160_abnormal_reproductive_system1.14246801
65MP0001529_abnormal_vocalization1.13031532
66MP0005330_cardiomyopathy1.10758533
67MP0003315_abnormal_perineum_morphology1.05280123
68MP0000751_myopathy1.03481601
69MP0001346_abnormal_lacrimal_gland1.02658555
70MP0001929_abnormal_gametogenesis1.01956559
71MP0009672_abnormal_birth_weight1.01850284
72MP0003221_abnormal_cardiomyocyte_apopto1.00881423
73MP0001849_ear_inflammation0.99028727
74MP0001661_extended_life_span0.98826175
75MP0000653_abnormal_sex_gland0.98303777
76MP0000566_synostosis0.97946087
77MP0000747_muscle_weakness0.94007376
78MP0000703_abnormal_thymus_morphology0.93878351
79MP0003186_abnormal_redox_activity0.93693951
80MP0005058_abnormal_lysosome_morphology0.92955620
81MP0009053_abnormal_anal_canal0.91273307
82MP0004233_abnormal_muscle_weight0.90055799
83MP0003656_abnormal_erythrocyte_physiolo0.89891375
84MP0009333_abnormal_splenocyte_physiolog0.89868242
85MP0005384_cellular_phenotype0.88470393
86MP0004147_increased_porphyrin_level0.88331353
87MP0009278_abnormal_bone_marrow0.87957640
88MP0005023_abnormal_wound_healing0.86953220
89MP0002111_abnormal_tail_morphology0.86803760
90MP0001915_intracranial_hemorrhage0.85466483
91MP0001881_abnormal_mammary_gland0.84701117
92MP0003566_abnormal_cell_adhesion0.84259081
93MP0006036_abnormal_mitochondrial_physio0.82869169
94MP0006054_spinal_hemorrhage0.82812785
95MP0009379_abnormal_foot_pigmentation0.82447257
96MP0005083_abnormal_biliary_tract0.80618020
97MP0006035_abnormal_mitochondrial_morpho0.80184408
98MP0000372_irregular_coat_pigmentation0.79143119
99MP0005408_hypopigmentation0.79135582
100MP0005266_abnormal_metabolism0.77940407
101MP0005621_abnormal_cell_physiology0.77634310
102MP0000750_abnormal_muscle_regeneration0.77074570
103MP0005389_reproductive_system_phenotype0.76776444
104MP0002269_muscular_atrophy0.76683088
105MP0002796_impaired_skin_barrier0.74662578
106MP0002722_abnormal_immune_system0.74476894
107MP0003763_abnormal_thymus_physiology0.74213206
108MP0000477_abnormal_intestine_morphology0.74080671
109MP0000858_altered_metastatic_potential0.74024973
110MP0004264_abnormal_extraembryonic_tissu0.73378634
111MP0002161_abnormal_fertility/fecundity0.73314529
112MP0000428_abnormal_craniofacial_morphol0.73131940
113MP0001853_heart_inflammation0.72307717
114MP0005636_abnormal_mineral_homeostasis0.71259949
115MP0001119_abnormal_female_reproductive0.71065429
116MP0001764_abnormal_homeostasis0.70070336
117MP0000681_abnormal_thyroid_gland0.68212972
118MP0002249_abnormal_larynx_morphology0.66972762
119MP0008770_decreased_survivor_rate0.65539098
120MP0009703_decreased_birth_body0.65353067
121MP0001905_abnormal_dopamine_level0.64974433
122MP0000689_abnormal_spleen_morphology0.64782813
123MP0002398_abnormal_bone_marrow0.64276497
124MP0003698_abnormal_male_reproductive0.63760368
125MP0004858_abnormal_nervous_system0.62503991
126MP0002089_abnormal_postnatal_growth/wei0.62073701
127MP0002092_abnormal_eye_morphology0.61492172
128MP0004185_abnormal_adipocyte_glucose0.60120274
129MP0005257_abnormal_intraocular_pressure0.59374943
130MP0003115_abnormal_respiratory_system0.58548807
131MP0006292_abnormal_olfactory_placode0.57118556
132MP0005395_other_phenotype0.56818897
133MP0000749_muscle_degeneration0.55385108
134MP0002970_abnormal_white_adipose0.55248510
135MP0009840_abnormal_foam_cell0.54569926
136MP0003941_abnormal_skin_development0.54456710
137MP0003937_abnormal_limbs/digits/tail_de0.54280437
138MP0003861_abnormal_nervous_system0.54115599
139MP0004084_abnormal_cardiac_muscle0.53982248
140MP0002132_abnormal_respiratory_system0.53884460
141MP0003878_abnormal_ear_physiology0.53795432
142MP0005377_hearing/vestibular/ear_phenot0.53795432
143MP0002429_abnormal_blood_cell0.52815585

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.42539850
2Ependymoma (HP:0002888)4.26026048
3Birth length less than 3rd percentile (HP:0003561)4.23625387
4Abnormality of cells of the erythroid lineage (HP:0012130)4.12661524
5Selective tooth agenesis (HP:0001592)4.05777940
6Reticulocytopenia (HP:0001896)4.05589903
7Microvesicular hepatic steatosis (HP:0001414)3.93878523
8Abnormal number of erythroid precursors (HP:0012131)3.89014364
9Oral leukoplakia (HP:0002745)3.87727933
10Colon cancer (HP:0003003)3.84300892
11Abnormal mitochondria in muscle tissue (HP:0008316)3.81612437
12Abnormality of glycolysis (HP:0004366)3.78881138
13Cholecystitis (HP:0001082)3.67626606
14Abnormal gallbladder physiology (HP:0012438)3.67626606
15Breast hypoplasia (HP:0003187)3.60576777
16Increased serum pyruvate (HP:0003542)3.55659766
17Ragged-red muscle fibers (HP:0003200)3.50590315
18Acute necrotizing encephalopathy (HP:0006965)3.46727932
19Hepatocellular necrosis (HP:0001404)3.44719022
20Carpal bone hypoplasia (HP:0001498)3.42349572
21Degeneration of anterior horn cells (HP:0002398)3.40765256
22Abnormality of the anterior horn cell (HP:0006802)3.40765256
23Abnormal respiratory motile cilium physiology (HP:0012261)3.29119691
24Medulloblastoma (HP:0002885)3.28775333
25Multiple enchondromatosis (HP:0005701)3.26262676
26Patellar aplasia (HP:0006443)3.21952749
27Acute encephalopathy (HP:0006846)3.20290394
28Mitochondrial inheritance (HP:0001427)3.16148805
29Hepatic necrosis (HP:0002605)3.07738998
30Increased intramyocellular lipid droplets (HP:0012240)3.05630949
31Microretrognathia (HP:0000308)3.05096913
32Aplasia/Hypoplasia of the patella (HP:0006498)3.04651306
33Rhinitis (HP:0012384)3.04605277
34Abnormal respiratory epithelium morphology (HP:0012253)3.03913236
35Abnormal respiratory motile cilium morphology (HP:0005938)3.03913236
36Increased CSF lactate (HP:0002490)3.03582048
37Chronic bronchitis (HP:0004469)2.91300587
38Cerebral hypomyelination (HP:0006808)2.89154214
39Exercise intolerance (HP:0003546)2.89002133
40Trismus (HP:0000211)2.88262828
41Rhabdomyosarcoma (HP:0002859)2.87817787
42Type I transferrin isoform profile (HP:0003642)2.81298512
43Aplastic anemia (HP:0001915)2.78959782
44Absent thumb (HP:0009777)2.76755473
45Increased serum lactate (HP:0002151)2.76685763
46Rough bone trabeculation (HP:0100670)2.75911825
47Neoplasm of the pancreas (HP:0002894)2.75566789
48Missing ribs (HP:0000921)2.74510188
49Premature ovarian failure (HP:0008209)2.73976510
5011 pairs of ribs (HP:0000878)2.73805943
51Abnormal ciliary motility (HP:0012262)2.70505819
52Agnosia (HP:0010524)2.69311173
53Increased muscle lipid content (HP:0009058)2.69153946
54Testicular atrophy (HP:0000029)2.66799104
55Abnormality of the astrocytes (HP:0100707)2.66348375
56Astrocytoma (HP:0009592)2.66348375
57Macrocytic anemia (HP:0001972)2.65270200
58Lactic acidosis (HP:0003128)2.61373915
59Cerebral edema (HP:0002181)2.61178074
60Chromsome breakage (HP:0040012)2.55311173
61Progressive muscle weakness (HP:0003323)2.52390592
62Basal cell carcinoma (HP:0002671)2.52188155
63Abnormal number of incisors (HP:0011064)2.51255040
64Absent radius (HP:0003974)2.50602115
65Atrophy/Degeneration involving motor neurons (HP:0007373)2.50248187
66Pallor (HP:0000980)2.49325145
67Increased nuchal translucency (HP:0010880)2.47578630
68Dynein arm defect of respiratory motile cilia (HP:0012255)2.45764252
69Absent/shortened dynein arms (HP:0200106)2.45764252
70Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.44533867
71Hypoplasia of the capital femoral epiphysis (HP:0003090)2.44390045
72Adenoma sebaceum (HP:0009720)2.44034765
73Angiofibromas (HP:0010615)2.44034765
74Meckel diverticulum (HP:0002245)2.43463187
75Progressive macrocephaly (HP:0004481)2.42667950
76Supernumerary spleens (HP:0009799)2.37042014
77Broad distal phalanx of finger (HP:0009836)2.36435269
78Glioma (HP:0009733)2.36162097
79Abnormality of the ileum (HP:0001549)2.35782923
80Insomnia (HP:0100785)2.34272088
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32934421
82Abnormal protein N-linked glycosylation (HP:0012347)2.32934421
83Abnormal protein glycosylation (HP:0012346)2.32934421
84Abnormal glycosylation (HP:0012345)2.32934421
85Absent forearm bone (HP:0003953)2.32182959
86Aplasia involving forearm bones (HP:0009822)2.32182959
87Hand muscle atrophy (HP:0009130)2.31619398
88Neoplasm of striated muscle (HP:0009728)2.30933862
89Abnormality of chromosome stability (HP:0003220)2.30469619
90Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28783043
91Upper limb muscle weakness (HP:0003484)2.28245284
92Emotional lability (HP:0000712)2.25054705
93Abnormality of the preputium (HP:0100587)2.23916786
94Atresia of the external auditory canal (HP:0000413)2.23580786
95Gout (HP:0001997)2.22913996
96Reduced antithrombin III activity (HP:0001976)2.21419546
97Tracheoesophageal fistula (HP:0002575)2.19855298
98Atelectasis (HP:0100750)2.19333934
99Secondary amenorrhea (HP:0000869)2.18738778
100Premature graying of hair (HP:0002216)2.18698030
101Increased hepatocellular lipid droplets (HP:0006565)2.18532905
102Respiratory failure (HP:0002878)2.15269252
103Male infertility (HP:0003251)2.14787887
104Proximal placement of thumb (HP:0009623)2.14102987
105Neoplasm of the oral cavity (HP:0100649)2.11153544
106Horseshoe kidney (HP:0000085)2.09857256
107Cellular immunodeficiency (HP:0005374)2.09748974
108Myelodysplasia (HP:0002863)2.09315355
109Aplasia/Hypoplasia of the uvula (HP:0010293)2.09305522
110Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08228342
111Distal upper limb amyotrophy (HP:0007149)2.07985741
112Upper limb amyotrophy (HP:0009129)2.07985741
113Abnormality of the lower motor neuron (HP:0002366)2.07982400
114Truncus arteriosus (HP:0001660)2.07692506
115Abdominal situs inversus (HP:0003363)2.06370890
116Abnormality of abdominal situs (HP:0011620)2.06370890
117Renal duplication (HP:0000075)2.06260331
118Slender long bone (HP:0003100)2.06120321
119Deviation of the thumb (HP:0009603)2.05949508
120Hyperthyroidism (HP:0000836)2.04940510
121Abnormality of the labia minora (HP:0012880)2.04669151
122Facial cleft (HP:0002006)2.04334107
123Hyperacusis (HP:0010780)2.03858159
124Lipid accumulation in hepatocytes (HP:0006561)2.03049792
125Duodenal stenosis (HP:0100867)2.02775725
126Small intestinal stenosis (HP:0012848)2.02775725
127Opisthotonus (HP:0002179)2.01786263
128Impulsivity (HP:0100710)2.00660238
129Abnormality of reticulocytes (HP:0004312)1.99995701
130Aplasia/hypoplasia of the humerus (HP:0006507)1.99927463
131Sparse eyelashes (HP:0000653)1.95506392
132Nasal polyposis (HP:0100582)1.95186241
133Squamous cell carcinoma (HP:0002860)1.95097925
134Abnormal trabecular bone morphology (HP:0100671)1.94611237
135Neoplasm of the colon (HP:0100273)1.94257796
136Thrombocytosis (HP:0001894)1.93485883
137Abnormality of pyrimidine metabolism (HP:0004353)1.93015291
138Glossoptosis (HP:0000162)1.91237455
139Abnormality of the umbilical cord (HP:0010881)1.90772425
140Bone marrow hypocellularity (HP:0005528)1.90400611
141Progressive microcephaly (HP:0000253)1.90018982
142Cafe-au-lait spot (HP:0000957)1.89900010
143Sloping forehead (HP:0000340)1.89162578
144Biliary tract neoplasm (HP:0100574)1.88582751
145High pitched voice (HP:0001620)1.88228344
146Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.88074368
147Absent epiphyses (HP:0010577)1.88074368
148Ovarian neoplasm (HP:0100615)1.87137607
149Prominent nose (HP:0000448)1.86363726
150Bronchiectasis (HP:0002110)1.86180214
151Fasciculations (HP:0002380)1.85776285
152Centrally nucleated skeletal muscle fibers (HP:0003687)1.84541160
153Spastic diplegia (HP:0001264)1.84448821
154Abnormality of the motor neurons (HP:0002450)1.84273504
155Abnormal neuron morphology (HP:0012757)1.84273504
156Pancytopenia (HP:0001876)1.84179832
157Shoulder girdle muscle weakness (HP:0003547)1.82823832
158Spinal muscular atrophy (HP:0007269)1.82670469
159Hypertensive crisis (HP:0100735)1.82634437
160Entropion (HP:0000621)1.82525713
161Personality changes (HP:0000751)1.82129687
162Hypergonadotropic hypogonadism (HP:0000815)1.80648396
163Intestinal polyp (HP:0005266)1.80493374
164Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79978003
165Death in infancy (HP:0001522)1.79840450
166Abnormal lung lobation (HP:0002101)1.78654031
167Abnormality of the calcaneus (HP:0008364)1.77881433
168Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77389764
169Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77389764
170Reticulocytosis (HP:0001923)1.76684661
171Abnormality of the duodenum (HP:0002246)1.76477930
172Amaurosis fugax (HP:0100576)1.76385132

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.66045821
2VRK24.58357408
3WEE14.26546207
4CDC74.07953997
5NEK12.84675774
6NEK22.84126626
7TTK2.41060197
8EIF2AK12.40002617
9PBK2.32095116
10TESK22.31298992
11SMG12.25490392
12EEF2K2.23753190
13TSSK62.23749875
14SCYL22.19956636
15RPS6KB22.06065578
16ACVR1B1.94993023
17PLK41.92522092
18ARAF1.87571794
19CDK121.82464041
20MAP3K101.80375224
21* PLK11.78775790
22PKN21.74962362
23CDK71.74648968
24PASK1.73784229
25SRPK11.68616804
26NME21.67115336
27EPHA21.66054305
28PAK41.59150076
29DYRK31.56153481
30MAP3K81.52388034
31AURKB1.51198777
32ATR1.49011035
33BRSK21.46595543
34MST41.45488390
35RPS6KA41.42577278
36CDK41.39281369
37AURKA1.38666263
38STK161.37946142
39MAP3K111.32391213
40EIF2AK31.28864645
41MAPKAPK31.28618249
42TRIB31.27208129
43VRK11.24830851
44BRSK11.24253396
45TESK11.23431015
46CHEK21.20803425
47STK101.19823932
48KDR1.15917362
49CHEK11.14643107
50IRAK31.13941900
51BCKDK1.12452881
52LRRK21.12106192
53TGFBR11.10043938
54PLK31.06098065
55FLT31.03051529
56TLK11.01854505
57PDK21.00189078
58MKNK10.97769445
59ALK0.97461913
60LATS20.95895270
61ABL20.93377898
62* CDK20.83838986
63CSNK1G30.81950622
64CCNB10.80812766
65PAK10.78160864
66MAPK150.72061229
67MAP2K30.71558455
68STK40.71477840
69ATM0.71472255
70CDK140.69141718
71PIM20.68970054
72CSNK2A20.68085669
73CLK10.65395388
74BRAF0.65116255
75CSNK1A1L0.64342895
76CDK180.63978325
77MTOR0.63612566
78MST1R0.63023087
79PNCK0.61279022
80PIM10.60520590
81PRKCI0.60124606
82AKT20.59438741
83MAP3K120.58805163
84CSNK2A10.57112836
85GRK60.54822056
86CDK80.54794450
87ILK0.53784040
88TAOK10.53753151
89CDK10.53613889
90CDK60.52163480
91DAPK10.52154579
92LMTK20.49981322
93LIMK10.48564071
94CSNK1E0.47935304
95MAPKAPK50.47680170
96PRKD30.46456665
97NTRK10.45903052
98ZAK0.44941847
99CSNK1G20.44773248
100PDK30.44036978
101PDK40.44036978
102CDK90.43874670
103MAP4K10.42855791
104CDK190.41920506
105CAMK2G0.41843789
106PAK60.41339013
107RAF10.39747035
108ERBB40.39345430
109MKNK20.37950608
110ERN10.37764974
111CSNK1G10.37744960
112BRD40.37549708
113ICK0.37015042
114TAOK20.36622824
115MAP2K20.35564489
116MAP2K70.35253785
117PAK20.34935297
118MELK0.32882201
119PTK20.31824814
120PRKDC0.30545771
121DAPK30.30365616
122RPS6KA10.28313163
123BMX0.28184432
124CDK11A0.27424493
125FGFR10.27421162
126STK38L0.26984784
127MAP3K30.26350054
128KSR20.24391161
129RPS6KA50.24256861
130MAPK110.23239599
131NME10.22673536
132CDK150.20632259

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.32629131
2Mismatch repair_Homo sapiens_hsa034304.41401748
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.64796695
4Spliceosome_Homo sapiens_hsa030403.53049802
5Ribosome_Homo sapiens_hsa030103.48136768
6RNA transport_Homo sapiens_hsa030133.25831713
7Proteasome_Homo sapiens_hsa030503.20120102
8Base excision repair_Homo sapiens_hsa034103.18004508
9One carbon pool by folate_Homo sapiens_hsa006702.86721088
10RNA polymerase_Homo sapiens_hsa030202.85641016
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.78357940
12Nucleotide excision repair_Homo sapiens_hsa034202.77200992
13Homologous recombination_Homo sapiens_hsa034402.75515187
14Cell cycle_Homo sapiens_hsa041102.66319473
15Pyrimidine metabolism_Homo sapiens_hsa002402.44917673
16Oxidative phosphorylation_Homo sapiens_hsa001902.07321041
17Fanconi anemia pathway_Homo sapiens_hsa034601.79107982
18RNA degradation_Homo sapiens_hsa030181.78812153
19mRNA surveillance pathway_Homo sapiens_hsa030151.78270654
20Fatty acid elongation_Homo sapiens_hsa000621.52860460
21Non-homologous end-joining_Homo sapiens_hsa034501.50186258
22Biosynthesis of amino acids_Homo sapiens_hsa012301.46681208
23p53 signaling pathway_Homo sapiens_hsa041151.45134670
24Basal transcription factors_Homo sapiens_hsa030221.42927548
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.31776151
26Phenylalanine metabolism_Homo sapiens_hsa003601.30727906
27Alzheimers disease_Homo sapiens_hsa050101.20847237
28Purine metabolism_Homo sapiens_hsa002301.18706914
29Sulfur relay system_Homo sapiens_hsa041221.17281985
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.16171079
31Pentose phosphate pathway_Homo sapiens_hsa000301.14159461
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13273116
33Oocyte meiosis_Homo sapiens_hsa041141.11254194
34Selenocompound metabolism_Homo sapiens_hsa004501.09785464
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07652736
36Epstein-Barr virus infection_Homo sapiens_hsa051691.07084722
37Folate biosynthesis_Homo sapiens_hsa007901.03182204
38Carbon metabolism_Homo sapiens_hsa012001.01201454
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96949278
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96869656
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93002684
42Systemic lupus erythematosus_Homo sapiens_hsa053220.92478973
43Tyrosine metabolism_Homo sapiens_hsa003500.92249112
44Thyroid cancer_Homo sapiens_hsa052160.90883933
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89712267
46Viral carcinogenesis_Homo sapiens_hsa052030.88736899
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86151019
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85280604
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.81796386
50Antigen processing and presentation_Homo sapiens_hsa046120.80757869
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78083886
52Vibrio cholerae infection_Homo sapiens_hsa051100.74723168
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73980011
54HTLV-I infection_Homo sapiens_hsa051660.71915399
55Fructose and mannose metabolism_Homo sapiens_hsa000510.69083194
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.65678014
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65544480
58Cardiac muscle contraction_Homo sapiens_hsa042600.65485295
59Bladder cancer_Homo sapiens_hsa052190.62274196
60Herpes simplex infection_Homo sapiens_hsa051680.60668530
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57821090
62Galactose metabolism_Homo sapiens_hsa000520.57171171
63Glutathione metabolism_Homo sapiens_hsa004800.56168138
64Hippo signaling pathway_Homo sapiens_hsa043900.55684368
65Huntingtons disease_Homo sapiens_hsa050160.54465546
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52458231
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51451695
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50777554
69Fatty acid metabolism_Homo sapiens_hsa012120.50470709
70Small cell lung cancer_Homo sapiens_hsa052220.48511945
71Synaptic vesicle cycle_Homo sapiens_hsa047210.48216224
72N-Glycan biosynthesis_Homo sapiens_hsa005100.47837355
73Colorectal cancer_Homo sapiens_hsa052100.46635370
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46508513
75Arginine biosynthesis_Homo sapiens_hsa002200.46473023
76MicroRNAs in cancer_Homo sapiens_hsa052060.46357049
77Notch signaling pathway_Homo sapiens_hsa043300.46256905
78Basal cell carcinoma_Homo sapiens_hsa052170.46195183
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44151719
80Peroxisome_Homo sapiens_hsa041460.42886114
81Steroid biosynthesis_Homo sapiens_hsa001000.40728843
82Pyruvate metabolism_Homo sapiens_hsa006200.39714737
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39459909
84Legionellosis_Homo sapiens_hsa051340.38916721
85Vitamin B6 metabolism_Homo sapiens_hsa007500.37410626
86mTOR signaling pathway_Homo sapiens_hsa041500.37343446
87Alcoholism_Homo sapiens_hsa050340.35057455
88Apoptosis_Homo sapiens_hsa042100.34393248
89Shigellosis_Homo sapiens_hsa051310.34264645
90HIF-1 signaling pathway_Homo sapiens_hsa040660.33907620
91Parkinsons disease_Homo sapiens_hsa050120.33253869
92Prion diseases_Homo sapiens_hsa050200.32726110
93TGF-beta signaling pathway_Homo sapiens_hsa043500.32553964
94beta-Alanine metabolism_Homo sapiens_hsa004100.32303651
95Chronic myeloid leukemia_Homo sapiens_hsa052200.31503240
96Propanoate metabolism_Homo sapiens_hsa006400.31066003
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30978765
98Hedgehog signaling pathway_Homo sapiens_hsa043400.29294762
99Acute myeloid leukemia_Homo sapiens_hsa052210.27409297
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27120255
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24833299
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23898870
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22176066
104Arginine and proline metabolism_Homo sapiens_hsa003300.20989143
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20197179
106Pathways in cancer_Homo sapiens_hsa052000.20085272
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19481527
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17835980
109Metabolic pathways_Homo sapiens_hsa011000.17302432
110Fatty acid degradation_Homo sapiens_hsa000710.17223863
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17083737
112Tight junction_Homo sapiens_hsa045300.14824907
113Non-small cell lung cancer_Homo sapiens_hsa052230.14820749
114Adherens junction_Homo sapiens_hsa045200.14488869
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.14357382
116Collecting duct acid secretion_Homo sapiens_hsa049660.13920925
117Hepatitis B_Homo sapiens_hsa051610.13735899
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13330289
119Lysine degradation_Homo sapiens_hsa003100.11320425
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.09432329
121Protein export_Homo sapiens_hsa030600.09429005
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.09043746
123Chemical carcinogenesis_Homo sapiens_hsa052040.06912645
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.06724151
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.05242383
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.04449373
127Wnt signaling pathway_Homo sapiens_hsa043100.03614435
128AMPK signaling pathway_Homo sapiens_hsa041520.03374236
129Endometrial cancer_Homo sapiens_hsa052130.03358049
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.03005548
131Sulfur metabolism_Homo sapiens_hsa009200.01467365

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