

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | maturation of SSU-rRNA (GO:0030490) | 4.63541555 |
| 2 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.60674845 |
| 3 | DNA unwinding involved in DNA replication (GO:0006268) | 4.51742000 |
| 4 | DNA replication initiation (GO:0006270) | 4.42858118 |
| 5 | ribosomal small subunit biogenesis (GO:0042274) | 4.39949736 |
| 6 | DNA strand elongation (GO:0022616) | 4.33037964 |
| 7 | translational termination (GO:0006415) | 4.28607303 |
| 8 | viral transcription (GO:0019083) | 4.27514528 |
| 9 | establishment of integrated proviral latency (GO:0075713) | 4.26333664 |
| 10 | nucleobase biosynthetic process (GO:0046112) | 4.25821055 |
| 11 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.23843652 |
| 12 | purine nucleobase biosynthetic process (GO:0009113) | 4.22972401 |
| 13 | formation of translation preinitiation complex (GO:0001731) | 4.16526788 |
| 14 | DNA replication checkpoint (GO:0000076) | 4.12081447 |
| 15 | ribosomal large subunit biogenesis (GO:0042273) | 4.10904550 |
| 16 | CENP-A containing nucleosome assembly (GO:0034080) | 4.02346297 |
| 17 | chromatin remodeling at centromere (GO:0031055) | 4.01757274 |
| 18 | ribosome assembly (GO:0042255) | 3.94871552 |
| 19 | telomere maintenance via recombination (GO:0000722) | 3.93371493 |
| 20 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.90356633 |
| 21 | cotranslational protein targeting to membrane (GO:0006613) | 3.89729997 |
| 22 | DNA ligation (GO:0006266) | 3.87788352 |
| 23 | cullin deneddylation (GO:0010388) | 3.84847574 |
| 24 | mitotic metaphase plate congression (GO:0007080) | 3.83973275 |
| 25 | protein targeting to ER (GO:0045047) | 3.83895945 |
| 26 | protein localization to kinetochore (GO:0034501) | 3.82608225 |
| 27 | ribosomal small subunit assembly (GO:0000028) | 3.81857838 |
| 28 | non-recombinational repair (GO:0000726) | 3.81118209 |
| 29 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.81118209 |
| 30 | translational elongation (GO:0006414) | 3.80173320 |
| 31 | translational initiation (GO:0006413) | 3.78663594 |
| 32 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.78603161 |
| 33 | mitotic recombination (GO:0006312) | 3.77805513 |
| 34 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.71336021 |
| 35 | kinetochore organization (GO:0051383) | 3.70230850 |
| 36 | mitotic sister chromatid segregation (GO:0000070) | 3.67153642 |
| 37 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.66273526 |
| 38 | protein localization to endoplasmic reticulum (GO:0070972) | 3.63946188 |
| 39 | regulation of centriole replication (GO:0046599) | 3.63450288 |
| 40 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.61373636 |
| 41 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.61373636 |
| 42 | DNA double-strand break processing (GO:0000729) | 3.61030369 |
| 43 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.60582836 |
| 44 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.60053766 |
| 45 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.58987546 |
| 46 | proteasome assembly (GO:0043248) | 3.58641104 |
| 47 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.57817899 |
| 48 | rRNA processing (GO:0006364) | 3.57353621 |
| 49 | DNA replication-independent nucleosome organization (GO:0034724) | 3.56511364 |
| 50 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.56511364 |
| 51 | spindle checkpoint (GO:0031577) | 3.54141756 |
| 52 | spliceosomal snRNP assembly (GO:0000387) | 3.53337461 |
| 53 | protein deneddylation (GO:0000338) | 3.53336673 |
| 54 | 7-methylguanosine mRNA capping (GO:0006370) | 3.52400057 |
| 55 | sister chromatid segregation (GO:0000819) | 3.51619648 |
| 56 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.51085572 |
| 57 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.50591853 |
| 58 | telomere maintenance via telomere lengthening (GO:0010833) | 3.48789106 |
| 59 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.48345651 |
| 60 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.48340538 |
| 61 | establishment of chromosome localization (GO:0051303) | 3.48067712 |
| 62 | 7-methylguanosine RNA capping (GO:0009452) | 3.46496537 |
| 63 | RNA capping (GO:0036260) | 3.46496537 |
| 64 | cellular protein complex disassembly (GO:0043624) | 3.45281081 |
| 65 | mitotic spindle checkpoint (GO:0071174) | 3.44841154 |
| 66 | rRNA metabolic process (GO:0016072) | 3.44796177 |
| 67 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.44758154 |
| 68 | histone exchange (GO:0043486) | 3.44644779 |
| 69 | establishment of viral latency (GO:0019043) | 3.44306862 |
| 70 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.43089146 |
| 71 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.43089146 |
| 72 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.43089146 |
| 73 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.43089146 |
| 74 | negative regulation of sister chromatid segregation (GO:0033046) | 3.43089146 |
| 75 | metaphase plate congression (GO:0051310) | 3.42116628 |
| 76 | viral life cycle (GO:0019058) | 3.41637609 |
| 77 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.41275606 |
| 78 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.40864767 |
| 79 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.40419188 |
| 80 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.40419188 |
| 81 | negative regulation of chromosome segregation (GO:0051985) | 3.40139214 |
| 82 | IMP metabolic process (GO:0046040) | 3.39150730 |
| 83 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.36963090 |
| 84 | negative regulation of ligase activity (GO:0051352) | 3.36963090 |
| 85 | pore complex assembly (GO:0046931) | 3.35101255 |
| 86 | ribosome biogenesis (GO:0042254) | 3.34838323 |
| 87 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.34745107 |
| 88 | termination of RNA polymerase III transcription (GO:0006386) | 3.34745107 |
| 89 | translation (GO:0006412) | 3.33383553 |
| 90 | kinetochore assembly (GO:0051382) | 3.32909006 |
| 91 | IMP biosynthetic process (GO:0006188) | 3.32836841 |
| 92 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.31740529 |
| 93 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.31740529 |
| 94 | mitotic sister chromatid cohesion (GO:0007064) | 3.31292233 |
| 95 | mitotic chromosome condensation (GO:0007076) | 3.30053996 |
| 96 | regulation of chromosome segregation (GO:0051983) | 3.29024324 |
| 97 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.28351275 |
| 98 | protein localization to chromosome, centromeric region (GO:0071459) | 3.27546004 |
| 99 | regulation of helicase activity (GO:0051095) | 3.27097504 |
| 100 | DNA damage response, detection of DNA damage (GO:0042769) | 3.26459220 |
| 101 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.25248032 |
| 102 | termination of RNA polymerase I transcription (GO:0006363) | 3.24511983 |
| 103 | mitotic nuclear envelope disassembly (GO:0007077) | 3.23116565 |
| 104 | nuclear pore organization (GO:0006999) | 3.22714470 |
| 105 | mitotic spindle assembly checkpoint (GO:0007094) | 3.21933348 |
| 106 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.20210101 |
| 107 | regulation of sister chromatid segregation (GO:0033045) | 3.20210101 |
| 108 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.20210101 |
| 109 | DNA topological change (GO:0006265) | 3.19998035 |
| 110 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.19853919 |
| 111 | cell cycle G1/S phase transition (GO:0044843) | 3.18767141 |
| 112 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.18767141 |
| 113 | spindle assembly checkpoint (GO:0071173) | 3.17731477 |
| 114 | maturation of 5.8S rRNA (GO:0000460) | 3.15913291 |
| 115 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.15909175 |
| 116 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.15909175 |
| 117 | membrane disassembly (GO:0030397) | 3.15448878 |
| 118 | nuclear envelope disassembly (GO:0051081) | 3.15448878 |
| 119 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.15409754 |
| 120 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.15409754 |
| 121 | isotype switching (GO:0045190) | 3.15409754 |
| 122 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.14707106 |
| 123 | ATP synthesis coupled proton transport (GO:0015986) | 3.14707106 |
| 124 | nuclear pore complex assembly (GO:0051292) | 3.13912344 |
| 125 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.13807523 |
| 126 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.13290778 |
| 127 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.13290778 |
| 128 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.13290778 |
| 129 | rRNA modification (GO:0000154) | 3.13275262 |
| 130 | spliceosomal complex assembly (GO:0000245) | 3.10942893 |
| 131 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.10652727 |
| 132 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.10007411 |
| 133 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.10007411 |
| 134 | tRNA aminoacylation for protein translation (GO:0006418) | 3.08847615 |
| 135 | replication fork processing (GO:0031297) | 3.08776756 |
| 136 | cellular component biogenesis (GO:0044085) | 3.07067987 |
| 137 | tRNA aminoacylation (GO:0043039) | 3.06886177 |
| 138 | amino acid activation (GO:0043038) | 3.06886177 |
| 139 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.06686541 |
| 140 | mitotic G2/M transition checkpoint (GO:0044818) | 3.05983961 |
| 141 | positive regulation of ligase activity (GO:0051351) | 3.05642884 |
| 142 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.05304896 |
| 143 | transcription from RNA polymerase I promoter (GO:0006360) | 3.02771763 |
| 144 | protein complex disassembly (GO:0043241) | 3.00504859 |
| 145 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.00209799 |
| 146 | positive regulation of chromosome segregation (GO:0051984) | 2.99929253 |
| 147 | regulation of spindle organization (GO:0090224) | 2.99762228 |
| 148 | folic acid metabolic process (GO:0046655) | 2.99371139 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.55177622 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.58197927 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.15391607 |
| 4 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.80161417 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.66448751 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.58349443 |
| 7 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.41482171 |
| 8 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.23230523 |
| 9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.19322765 |
| 10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.17667376 |
| 11 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.13878687 |
| 12 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.07079124 |
| 13 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 3.00746097 |
| 14 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.98870691 |
| 15 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.98019977 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.93839731 |
| 17 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.93724033 |
| 18 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.68709821 |
| 19 | * HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.66259921 |
| 20 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.47766626 |
| 21 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.46190777 |
| 22 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.45786511 |
| 23 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.45528645 |
| 24 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.39353492 |
| 25 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.32014620 |
| 26 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.28206572 |
| 27 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.25754951 |
| 28 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.21484000 |
| 29 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.17330969 |
| 30 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.16797141 |
| 31 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 2.15322201 |
| 32 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.11328827 |
| 33 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.09863818 |
| 34 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.06579524 |
| 35 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 2.06123195 |
| 36 | * MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.95907835 |
| 37 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.95869181 |
| 38 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.93675493 |
| 39 | * THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.91182140 |
| 40 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.84699507 |
| 41 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.83567266 |
| 42 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.82250094 |
| 43 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.81838072 |
| 44 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.79586664 |
| 45 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.77973697 |
| 46 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.75260299 |
| 47 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.74918453 |
| 48 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.66961679 |
| 49 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.65648300 |
| 50 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.55409337 |
| 51 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.54925005 |
| 52 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.53038483 |
| 53 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.51265146 |
| 54 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.49296107 |
| 55 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.48584410 |
| 56 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.39965413 |
| 57 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.31561191 |
| 58 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.24304885 |
| 59 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.22189320 |
| 60 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.22058596 |
| 61 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.21376750 |
| 62 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.20986144 |
| 63 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.20016513 |
| 64 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.18723757 |
| 65 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.18407745 |
| 66 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.16730146 |
| 67 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.12580340 |
| 68 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.10729695 |
| 69 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.10319962 |
| 70 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.09537786 |
| 71 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.08795960 |
| 72 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.07928710 |
| 73 | * SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.05429059 |
| 74 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.02034997 |
| 75 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.01054238 |
| 76 | * HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.99093747 |
| 77 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.97699990 |
| 78 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.96981279 |
| 79 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.96955379 |
| 80 | * SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.94949541 |
| 81 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.94788246 |
| 82 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.91785656 |
| 83 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.91565993 |
| 84 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.90901109 |
| 85 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.90366424 |
| 86 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87102106 |
| 87 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.86553133 |
| 88 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.86127188 |
| 89 | FUS_26573619_Chip-Seq_HEK293_Human | 0.84024371 |
| 90 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.83713764 |
| 91 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.81135780 |
| 92 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.79924248 |
| 93 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.79484059 |
| 94 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.78896793 |
| 95 | * VDR_22108803_ChIP-Seq_LS180_Human | 0.78010108 |
| 96 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.77728380 |
| 97 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.77269724 |
| 98 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.76985243 |
| 99 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.76581852 |
| 100 | EWS_26573619_Chip-Seq_HEK293_Human | 0.76454633 |
| 101 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.76391989 |
| 102 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.76239316 |
| 103 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.75628607 |
| 104 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.75398855 |
| 105 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.73849330 |
| 106 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.73693167 |
| 107 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.73364171 |
| 108 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.73362038 |
| 109 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.71319817 |
| 110 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.69260365 |
| 111 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.68654128 |
| 112 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.68054393 |
| 113 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.67042081 |
| 114 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.66754009 |
| 115 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.65712140 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.27115578 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.75978389 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.74986473 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.06173481 |
| 5 | MP0008057_abnormal_DNA_replication | 4.04089957 |
| 6 | MP0003077_abnormal_cell_cycle | 3.81319174 |
| 7 | MP0008058_abnormal_DNA_repair | 3.33088233 |
| 8 | MP0008932_abnormal_embryonic_tissue | 3.21751268 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.63952586 |
| 10 | MP0003123_paternal_imprinting | 2.62510833 |
| 11 | MP0008877_abnormal_DNA_methylation | 2.53269562 |
| 12 | MP0001730_embryonic_growth_arrest | 2.34374567 |
| 13 | MP0003806_abnormal_nucleotide_metabolis | 2.24601534 |
| 14 | MP0003718_maternal_effect | 2.17723409 |
| 15 | MP0000350_abnormal_cell_proliferation | 2.17222687 |
| 16 | MP0003786_premature_aging | 2.16291305 |
| 17 | MP0009379_abnormal_foot_pigmentation | 1.97140414 |
| 18 | MP0001529_abnormal_vocalization | 1.81196764 |
| 19 | MP0003890_abnormal_embryonic-extraembry | 1.80687415 |
| 20 | MP0000537_abnormal_urethra_morphology | 1.76322102 |
| 21 | MP0003121_genomic_imprinting | 1.75679754 |
| 22 | MP0009697_abnormal_copulation | 1.75379059 |
| 23 | MP0001697_abnormal_embryo_size | 1.69081514 |
| 24 | MP0003941_abnormal_skin_development | 1.61711231 |
| 25 | MP0003315_abnormal_perineum_morphology | 1.55507868 |
| 26 | MP0002396_abnormal_hematopoietic_system | 1.54148185 |
| 27 | MP0002080_prenatal_lethality | 1.50492019 |
| 28 | MP0002085_abnormal_embryonic_tissue | 1.49363309 |
| 29 | MP0010352_gastrointestinal_tract_polyps | 1.48601894 |
| 30 | MP0005380_embryogenesis_phenotype | 1.48421051 |
| 31 | MP0001672_abnormal_embryogenesis/_devel | 1.48421051 |
| 32 | MP0001293_anophthalmia | 1.45635497 |
| 33 | MP0003937_abnormal_limbs/digits/tail_de | 1.40950229 |
| 34 | MP0002084_abnormal_developmental_patter | 1.39411508 |
| 35 | MP0002102_abnormal_ear_morphology | 1.33789080 |
| 36 | MP0002938_white_spotting | 1.32817335 |
| 37 | MP0004197_abnormal_fetal_growth/weight/ | 1.32499417 |
| 38 | MP0010307_abnormal_tumor_latency | 1.31810012 |
| 39 | MP0002210_abnormal_sex_determination | 1.30606194 |
| 40 | MP0006054_spinal_hemorrhage | 1.23343391 |
| 41 | MP0010030_abnormal_orbit_morphology | 1.21313269 |
| 42 | MP0003984_embryonic_growth_retardation | 1.20019597 |
| 43 | MP0001145_abnormal_male_reproductive | 1.19275224 |
| 44 | MP0009053_abnormal_anal_canal | 1.17878328 |
| 45 | MP0002088_abnormal_embryonic_growth/wei | 1.17772264 |
| 46 | MP0000313_abnormal_cell_death | 1.17247761 |
| 47 | MP0006035_abnormal_mitochondrial_morpho | 1.16395963 |
| 48 | MP0000358_abnormal_cell_content/ | 1.15039588 |
| 49 | MP0009672_abnormal_birth_weight | 1.12739991 |
| 50 | MP0001929_abnormal_gametogenesis | 1.11300004 |
| 51 | MP0003567_abnormal_fetal_cardiomyocyte | 1.08773864 |
| 52 | MP0000490_abnormal_crypts_of | 1.08597450 |
| 53 | MP0002233_abnormal_nose_morphology | 1.08231442 |
| 54 | MP0004133_heterotaxia | 1.08137640 |
| 55 | MP0006292_abnormal_olfactory_placode | 1.07458607 |
| 56 | MP0003221_abnormal_cardiomyocyte_apopto | 1.06022141 |
| 57 | MP0002234_abnormal_pharynx_morphology | 1.05850230 |
| 58 | MP0000653_abnormal_sex_gland | 1.05245954 |
| 59 | MP0002160_abnormal_reproductive_system | 1.04904136 |
| 60 | MP0006072_abnormal_retinal_apoptosis | 1.04703617 |
| 61 | MP0001286_abnormal_eye_development | 1.04103586 |
| 62 | MP0005395_other_phenotype | 1.02831038 |
| 63 | MP0002019_abnormal_tumor_incidence | 0.99928719 |
| 64 | MP0002111_abnormal_tail_morphology | 0.99859573 |
| 65 | MP0000647_abnormal_sebaceous_gland | 0.98631615 |
| 66 | MP0005408_hypopigmentation | 0.98351894 |
| 67 | MP0002086_abnormal_extraembryonic_tissu | 0.98298035 |
| 68 | MP0005501_abnormal_skin_physiology | 0.96457885 |
| 69 | MP0003186_abnormal_redox_activity | 0.96328897 |
| 70 | MP0005389_reproductive_system_phenotype | 0.93266882 |
| 71 | MP0009333_abnormal_splenocyte_physiolog | 0.88570271 |
| 72 | MP0003136_yellow_coat_color | 0.88478583 |
| 73 | MP0008789_abnormal_olfactory_epithelium | 0.88355135 |
| 74 | MP0003938_abnormal_ear_development | 0.88203107 |
| 75 | MP0003119_abnormal_digestive_system | 0.82895535 |
| 76 | MP0002796_impaired_skin_barrier | 0.82017210 |
| 77 | MP0009703_decreased_birth_body | 0.81385624 |
| 78 | MP0000762_abnormal_tongue_morphology | 0.81060701 |
| 79 | MP0000566_synostosis | 0.80004403 |
| 80 | MP0001188_hyperpigmentation | 0.78592267 |
| 81 | MP0003942_abnormal_urinary_system | 0.78270765 |
| 82 | MP0002092_abnormal_eye_morphology | 0.76916699 |
| 83 | MP0002282_abnormal_trachea_morphology | 0.76708124 |
| 84 | MP0006036_abnormal_mitochondrial_physio | 0.76378654 |
| 85 | MP0002751_abnormal_autonomic_nervous | 0.75561393 |
| 86 | MP0000049_abnormal_middle_ear | 0.74539660 |
| 87 | MP0003698_abnormal_male_reproductive | 0.74463024 |
| 88 | MP0000579_abnormal_nail_morphology | 0.73079804 |
| 89 | MP0001881_abnormal_mammary_gland | 0.72642200 |
| 90 | MP0001119_abnormal_female_reproductive | 0.72479443 |
| 91 | MP0004272_abnormal_basement_membrane | 0.69957957 |
| 92 | MP0003861_abnormal_nervous_system | 0.68918347 |
| 93 | MP0005410_abnormal_fertilization | 0.68078798 |
| 94 | MP0002006_tumorigenesis | 0.67019173 |
| 95 | MP0005384_cellular_phenotype | 0.66051066 |
| 96 | MP0001299_abnormal_eye_distance/ | 0.65631500 |
| 97 | MP0000627_abnormal_mammary_gland | 0.64215601 |
| 98 | MP0005391_vision/eye_phenotype | 0.62327399 |
| 99 | MP0000432_abnormal_head_morphology | 0.61931804 |
| 100 | MP0000428_abnormal_craniofacial_morphol | 0.61833733 |
| 101 | MP0001905_abnormal_dopamine_level | 0.61442881 |
| 102 | MP0002254_reproductive_system_inflammat | 0.61362181 |
| 103 | MP0003950_abnormal_plasma_membrane | 0.61282727 |
| 104 | MP0003699_abnormal_female_reproductive | 0.61192397 |
| 105 | MP0001727_abnormal_embryo_implantation | 0.60890881 |
| 106 | MP0004233_abnormal_muscle_weight | 0.59621010 |
| 107 | MP0004808_abnormal_hematopoietic_stem | 0.59447393 |
| 108 | MP0002161_abnormal_fertility/fecundity | 0.59422193 |
| 109 | MP0005253_abnormal_eye_physiology | 0.59320916 |
| 110 | MP0002114_abnormal_axial_skeleton | 0.59279716 |
| 111 | MP0003935_abnormal_craniofacial_develop | 0.59200739 |
| 112 | MP0002697_abnormal_eye_size | 0.57323172 |
| 113 | MP0000749_muscle_degeneration | 0.57043556 |
| 114 | MP0010234_abnormal_vibrissa_follicle | 0.56617415 |
| 115 | MP0001542_abnormal_bone_strength | 0.56085474 |
| 116 | MP0000703_abnormal_thymus_morphology | 0.55905101 |
| 117 | MP0003755_abnormal_palate_morphology | 0.55772464 |
| 118 | MP0001177_atelectasis | 0.55521999 |
| 119 | MP0001243_abnormal_dermal_layer | 0.55006779 |
| 120 | MP0003936_abnormal_reproductive_system | 0.54801294 |
| 121 | MP0002177_abnormal_outer_ear | 0.54418598 |
| 122 | MP0001919_abnormal_reproductive_system | 0.54370722 |
| 123 | MP0005394_taste/olfaction_phenotype | 0.54265735 |
| 124 | MP0005499_abnormal_olfactory_system | 0.54265735 |
| 125 | MP0001764_abnormal_homeostasis | 0.53627599 |
| 126 | MP0005266_abnormal_metabolism | 0.52390704 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 5.42104291 |
| 2 | Reticulocytopenia (HP:0001896) | 4.34146166 |
| 3 | Breast hypoplasia (HP:0003187) | 4.18881470 |
| 4 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.08829519 |
| 5 | Increased serum pyruvate (HP:0003542) | 3.78615501 |
| 6 | Abnormality of glycolysis (HP:0004366) | 3.78615501 |
| 7 | Abnormal number of erythroid precursors (HP:0012131) | 3.43413712 |
| 8 | Acute necrotizing encephalopathy (HP:0006965) | 3.35888022 |
| 9 | Macrocytic anemia (HP:0001972) | 3.31121971 |
| 10 | Chromsome breakage (HP:0040012) | 3.24528114 |
| 11 | Colon cancer (HP:0003003) | 3.16043397 |
| 12 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.10742065 |
| 13 | Volvulus (HP:0002580) | 3.07280545 |
| 14 | Oral leukoplakia (HP:0002745) | 2.98503892 |
| 15 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.93562755 |
| 16 | Selective tooth agenesis (HP:0001592) | 2.87477362 |
| 17 | Pallor (HP:0000980) | 2.86729381 |
| 18 | Cerebral hypomyelination (HP:0006808) | 2.84794146 |
| 19 | Stenosis of the external auditory canal (HP:0000402) | 2.80493125 |
| 20 | Embryonal renal neoplasm (HP:0011794) | 2.80225897 |
| 21 | Abnormality of the preputium (HP:0100587) | 2.79592979 |
| 22 | Patellar aplasia (HP:0006443) | 2.76970894 |
| 23 | Mitochondrial inheritance (HP:0001427) | 2.76264530 |
| 24 | Absent radius (HP:0003974) | 2.71239393 |
| 25 | Abnormality of the anterior horn cell (HP:0006802) | 2.70490600 |
| 26 | Degeneration of anterior horn cells (HP:0002398) | 2.70490600 |
| 27 | Increased CSF lactate (HP:0002490) | 2.67778262 |
| 28 | Rough bone trabeculation (HP:0100670) | 2.66936991 |
| 29 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.66463601 |
| 30 | Abnormality of methionine metabolism (HP:0010901) | 2.66150155 |
| 31 | Glossoptosis (HP:0000162) | 2.65919355 |
| 32 | Abnormality of chromosome stability (HP:0003220) | 2.62721825 |
| 33 | Increased hepatocellular lipid droplets (HP:0006565) | 2.62096873 |
| 34 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.60013091 |
| 35 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.59400677 |
| 36 | Acute encephalopathy (HP:0006846) | 2.58251061 |
| 37 | Progressive macrocephaly (HP:0004481) | 2.57147775 |
| 38 | Abnormality of the labia minora (HP:0012880) | 2.54534812 |
| 39 | Aplasia involving forearm bones (HP:0009822) | 2.54362031 |
| 40 | Absent forearm bone (HP:0003953) | 2.54362031 |
| 41 | Meckel diverticulum (HP:0002245) | 2.48614757 |
| 42 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.47401093 |
| 43 | Aplastic anemia (HP:0001915) | 2.45908920 |
| 44 | Increased nuchal translucency (HP:0010880) | 2.43376724 |
| 45 | Abnormality of the ileum (HP:0001549) | 2.38283949 |
| 46 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.38152693 |
| 47 | Medulloblastoma (HP:0002885) | 2.35021051 |
| 48 | Horseshoe kidney (HP:0000085) | 2.31708174 |
| 49 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.31045266 |
| 50 | Agnosia (HP:0010524) | 2.29272422 |
| 51 | Hypoplasia of the pons (HP:0012110) | 2.27665767 |
| 52 | Lipid accumulation in hepatocytes (HP:0006561) | 2.27082944 |
| 53 | Multiple enchondromatosis (HP:0005701) | 2.25190470 |
| 54 | Abnormality of placental membranes (HP:0011409) | 2.23584801 |
| 55 | Amniotic constriction ring (HP:0009775) | 2.23584801 |
| 56 | Abnormality of the pons (HP:0007361) | 2.22446623 |
| 57 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.21890882 |
| 58 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.21890882 |
| 59 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.20358875 |
| 60 | Neoplasm of the pancreas (HP:0002894) | 2.19551662 |
| 61 | Increased serum lactate (HP:0002151) | 2.18273766 |
| 62 | Hypoplastic pelvis (HP:0008839) | 2.17527694 |
| 63 | Triphalangeal thumb (HP:0001199) | 2.16703143 |
| 64 | Cortical dysplasia (HP:0002539) | 2.15582573 |
| 65 | Abnormality of the carotid arteries (HP:0005344) | 2.15540567 |
| 66 | Abnormality of serum amino acid levels (HP:0003112) | 2.15184555 |
| 67 | Type I transferrin isoform profile (HP:0003642) | 2.12670582 |
| 68 | Glioma (HP:0009733) | 2.11687310 |
| 69 | Absent thumb (HP:0009777) | 2.11418285 |
| 70 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 2.11136180 |
| 71 | Absent epiphyses (HP:0010577) | 2.11136180 |
| 72 | Premature graying of hair (HP:0002216) | 2.09170798 |
| 73 | Duplicated collecting system (HP:0000081) | 2.07691656 |
| 74 | Duodenal stenosis (HP:0100867) | 2.06738497 |
| 75 | Small intestinal stenosis (HP:0012848) | 2.06738497 |
| 76 | Proximal placement of thumb (HP:0009623) | 2.05935707 |
| 77 | Hepatocellular necrosis (HP:0001404) | 2.05763631 |
| 78 | 3-Methylglutaconic aciduria (HP:0003535) | 2.05107226 |
| 79 | Reduced antithrombin III activity (HP:0001976) | 2.03776581 |
| 80 | Atresia of the external auditory canal (HP:0000413) | 2.03638676 |
| 81 | 11 pairs of ribs (HP:0000878) | 2.03412882 |
| 82 | Myelodysplasia (HP:0002863) | 2.02388403 |
| 83 | Microretrognathia (HP:0000308) | 1.99390150 |
| 84 | Supernumerary spleens (HP:0009799) | 1.99026662 |
| 85 | Microglossia (HP:0000171) | 1.97571837 |
| 86 | Clubbing of toes (HP:0100760) | 1.96985254 |
| 87 | Abnormal lung lobation (HP:0002101) | 1.96846286 |
| 88 | Carpal bone hypoplasia (HP:0001498) | 1.96159923 |
| 89 | Deviation of the thumb (HP:0009603) | 1.96077230 |
| 90 | Sparse lateral eyebrow (HP:0005338) | 1.96060597 |
| 91 | Microvesicular hepatic steatosis (HP:0001414) | 1.95414943 |
| 92 | Cellular immunodeficiency (HP:0005374) | 1.92929830 |
| 93 | Abnormal number of incisors (HP:0011064) | 1.91815702 |
| 94 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.91804460 |
| 95 | Abnormality of the renal collecting system (HP:0004742) | 1.91715927 |
| 96 | Hepatic necrosis (HP:0002605) | 1.91591269 |
| 97 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.90447582 |
| 98 | Rhabdomyosarcoma (HP:0002859) | 1.90400868 |
| 99 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.89754331 |
| 100 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.89754331 |
| 101 | Abnormal protein glycosylation (HP:0012346) | 1.89754331 |
| 102 | Abnormal glycosylation (HP:0012345) | 1.89754331 |
| 103 | Facial cleft (HP:0002006) | 1.89066907 |
| 104 | Sloping forehead (HP:0000340) | 1.88055474 |
| 105 | Exercise intolerance (HP:0003546) | 1.87862330 |
| 106 | Abnormality of the septum pellucidum (HP:0007375) | 1.87463085 |
| 107 | Cerebral edema (HP:0002181) | 1.86852637 |
| 108 | Abnormality of alanine metabolism (HP:0010916) | 1.86700518 |
| 109 | Hyperalaninemia (HP:0003348) | 1.86700518 |
| 110 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.86700518 |
| 111 | Absent septum pellucidum (HP:0001331) | 1.86069038 |
| 112 | Bone marrow hypocellularity (HP:0005528) | 1.85526694 |
| 113 | Abnormal trabecular bone morphology (HP:0100671) | 1.85073792 |
| 114 | Ependymoma (HP:0002888) | 1.84907495 |
| 115 | Renal Fanconi syndrome (HP:0001994) | 1.84117799 |
| 116 | Trismus (HP:0000211) | 1.83631301 |
| 117 | Megaloblastic anemia (HP:0001889) | 1.81601941 |
| 118 | Irregular epiphyses (HP:0010582) | 1.81255701 |
| 119 | Neoplasm of the colon (HP:0100273) | 1.81008047 |
| 120 | Impulsivity (HP:0100710) | 1.80913102 |
| 121 | Abnormality of the duodenum (HP:0002246) | 1.80313083 |
| 122 | Septo-optic dysplasia (HP:0100842) | 1.79810797 |
| 123 | Leukodystrophy (HP:0002415) | 1.79332648 |
| 124 | Exertional dyspnea (HP:0002875) | 1.79217766 |
| 125 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.78374227 |
| 126 | Postnatal microcephaly (HP:0005484) | 1.77404853 |
| 127 | Fibular aplasia (HP:0002990) | 1.77110128 |
| 128 | Shoulder girdle muscle weakness (HP:0003547) | 1.77093406 |
| 129 | Bifid tongue (HP:0010297) | 1.76054045 |
| 130 | Lactic acidosis (HP:0003128) | 1.75776110 |
| 131 | Methylmalonic acidemia (HP:0002912) | 1.75090813 |
| 132 | Spastic diplegia (HP:0001264) | 1.73977382 |
| 133 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.71758159 |
| 134 | Choanal atresia (HP:0000453) | 1.70553642 |
| 135 | Astrocytoma (HP:0009592) | 1.70270212 |
| 136 | Abnormality of the astrocytes (HP:0100707) | 1.70270212 |
| 137 | Progressive external ophthalmoplegia (HP:0000590) | 1.69311270 |
| 138 | Short tibia (HP:0005736) | 1.68333628 |
| 139 | Abnormal auditory evoked potentials (HP:0006958) | 1.66431432 |
| 140 | Secondary amenorrhea (HP:0000869) | 1.66301535 |
| 141 | Ovarian neoplasm (HP:0100615) | 1.65899460 |
| 142 | Sparse eyelashes (HP:0000653) | 1.63769676 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | WEE1 | 4.65462548 |
| 2 | BUB1 | 4.14452402 |
| 3 | CDC7 | 3.91009933 |
| 4 | SRPK1 | 3.26852652 |
| 5 | EIF2AK1 | 3.17105552 |
| 6 | VRK2 | 3.01880644 |
| 7 | STK16 | 2.59379381 |
| 8 | NME2 | 2.56912397 |
| 9 | BRSK2 | 2.55007470 |
| 10 | VRK1 | 2.53618438 |
| 11 | TSSK6 | 2.50443359 |
| 12 | ACVR1B | 2.32354138 |
| 13 | EIF2AK3 | 2.30792133 |
| 14 | TRIM28 | 2.05080911 |
| 15 | PNCK | 2.04759614 |
| 16 | MKNK1 | 2.01177861 |
| 17 | PLK3 | 1.98079211 |
| 18 | TAF1 | 1.93351004 |
| 19 | PLK4 | 1.92477578 |
| 20 | TTK | 1.89446799 |
| 21 | TLK1 | 1.84827030 |
| 22 | TESK2 | 1.84053230 |
| 23 | PASK | 1.82215794 |
| 24 | CCNB1 | 1.78969710 |
| 25 | PLK1 | 1.77486005 |
| 26 | MST4 | 1.68764809 |
| 27 | NUAK1 | 1.62835517 |
| 28 | AURKB | 1.60972979 |
| 29 | DYRK3 | 1.54676455 |
| 30 | NEK2 | 1.53160991 |
| 31 | NEK1 | 1.48021080 |
| 32 | PBK | 1.45399421 |
| 33 | AURKA | 1.37771382 |
| 34 | BRSK1 | 1.37415535 |
| 35 | ATR | 1.30773849 |
| 36 | RPS6KB2 | 1.29307684 |
| 37 | CDK7 | 1.27849409 |
| 38 | BCR | 1.26873411 |
| 39 | LIMK1 | 1.24509631 |
| 40 | CHEK2 | 1.23161769 |
| 41 | TNIK | 1.15987994 |
| 42 | TGFBR1 | 1.13480601 |
| 43 | EPHA2 | 1.13265856 |
| 44 | NME1 | 1.11158749 |
| 45 | PDK3 | 1.08859385 |
| 46 | PDK4 | 1.08859385 |
| 47 | WNK3 | 1.01683824 |
| 48 | ZAK | 0.99144122 |
| 49 | SCYL2 | 0.98027858 |
| 50 | CHEK1 | 0.95616463 |
| 51 | FLT3 | 0.93020679 |
| 52 | MKNK2 | 0.92309968 |
| 53 | MAP3K8 | 0.91694051 |
| 54 | CSNK1G3 | 0.89604725 |
| 55 | BRAF | 0.84095716 |
| 56 | TESK1 | 0.82552315 |
| 57 | CDK8 | 0.80851068 |
| 58 | CSNK2A2 | 0.79638280 |
| 59 | EIF2AK2 | 0.79462154 |
| 60 | TIE1 | 0.79253981 |
| 61 | ATM | 0.76605587 |
| 62 | MAP4K2 | 0.75773869 |
| 63 | RPS6KA5 | 0.75639796 |
| 64 | CSNK2A1 | 0.73693716 |
| 65 | BMPR1B | 0.73367760 |
| 66 | DYRK2 | 0.72572122 |
| 67 | MELK | 0.71021372 |
| 68 | ALK | 0.67787023 |
| 69 | RPS6KA4 | 0.66720697 |
| 70 | CDK4 | 0.63669581 |
| 71 | DAPK1 | 0.62988297 |
| 72 | CDK2 | 0.62330548 |
| 73 | STK10 | 0.61245688 |
| 74 | CLK1 | 0.60915148 |
| 75 | CSNK1G1 | 0.60711840 |
| 76 | LRRK2 | 0.60463496 |
| 77 | PAK1 | 0.59013715 |
| 78 | CASK | 0.58211229 |
| 79 | CDK1 | 0.56268438 |
| 80 | STK4 | 0.56195819 |
| 81 | PLK2 | 0.55842542 |
| 82 | ERBB4 | 0.55268863 |
| 83 | LATS1 | 0.55139842 |
| 84 | FGFR1 | 0.50985547 |
| 85 | ARAF | 0.49872823 |
| 86 | PRKCI | 0.48818736 |
| 87 | BRD4 | 0.48202067 |
| 88 | LATS2 | 0.47242458 |
| 89 | PAK4 | 0.47025850 |
| 90 | PDK2 | 0.46992903 |
| 91 | MET | 0.46591598 |
| 92 | CSNK1A1L | 0.44879567 |
| 93 | MAP3K4 | 0.42989308 |
| 94 | PIM2 | 0.42326045 |
| 95 | CDK14 | 0.41552959 |
| 96 | CSNK1E | 0.41352229 |
| 97 | NEK9 | 0.40431631 |
| 98 | MINK1 | 0.40354767 |
| 99 | CSNK1G2 | 0.40054952 |
| 100 | CDK18 | 0.39247750 |
| 101 | YES1 | 0.37699470 |
| 102 | CDK15 | 0.37591910 |
| 103 | CDK9 | 0.37299138 |
| 104 | MAP2K7 | 0.35981144 |
| 105 | CDK11A | 0.34780477 |
| 106 | STK38L | 0.32113048 |
| 107 | STK3 | 0.30861360 |
| 108 | ERBB3 | 0.30380217 |
| 109 | MST1R | 0.29384580 |
| 110 | CSNK1D | 0.27303561 |
| 111 | PRKDC | 0.27259316 |
| 112 | CDK19 | 0.24966652 |
| 113 | ILK | 0.24831809 |
| 114 | ADRBK1 | 0.24727257 |
| 115 | ABL2 | 0.23055829 |
| 116 | BCKDK | 0.22690350 |
| 117 | CDK6 | 0.21905448 |
| 118 | KDR | 0.21555908 |
| 119 | NEK6 | 0.21307257 |
| 120 | MAP3K12 | 0.21031933 |
| 121 | CDK3 | 0.20665381 |
| 122 | EGFR | 0.20211290 |
| 123 | UHMK1 | 0.19982864 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.39366831 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.15112647 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 4.11415544 |
| 4 | Mismatch repair_Homo sapiens_hsa03430 | 3.88466812 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.71842924 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.45070468 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 3.17405094 |
| 8 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.96939120 |
| 9 | RNA transport_Homo sapiens_hsa03013 | 2.91450459 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.81579073 |
| 11 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.60141979 |
| 12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.51995148 |
| 13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.51798671 |
| 14 | Protein export_Homo sapiens_hsa03060 | 2.44457743 |
| 15 | Cell cycle_Homo sapiens_hsa04110 | 2.38328794 |
| 16 | Base excision repair_Homo sapiens_hsa03410 | 2.33030492 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 2.08624579 |
| 18 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.08142161 |
| 19 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.05427147 |
| 20 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.04769573 |
| 21 | Parkinsons disease_Homo sapiens_hsa05012 | 1.89072575 |
| 22 | RNA degradation_Homo sapiens_hsa03018 | 1.83619712 |
| 23 | Huntingtons disease_Homo sapiens_hsa05016 | 1.65627609 |
| 24 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.43357530 |
| 25 | Purine metabolism_Homo sapiens_hsa00230 | 1.41806998 |
| 26 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.38352992 |
| 27 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.35871957 |
| 28 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.35741577 |
| 29 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.32426057 |
| 30 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.17981244 |
| 31 | Alzheimers disease_Homo sapiens_hsa05010 | 1.16460266 |
| 32 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.04864718 |
| 33 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.98627373 |
| 34 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.98626421 |
| 35 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.92572592 |
| 36 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.91886598 |
| 37 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.90465038 |
| 38 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.87815486 |
| 39 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.86160724 |
| 40 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.82364150 |
| 41 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.82258716 |
| 42 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.82011791 |
| 43 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.76083139 |
| 44 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.76044067 |
| 45 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.71440598 |
| 46 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.69532689 |
| 47 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.68134360 |
| 48 | Alcoholism_Homo sapiens_hsa05034 | 0.67514823 |
| 49 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.64416472 |
| 50 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.64306864 |
| 51 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.57035584 |
| 52 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.56310716 |
| 53 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.55564459 |
| 54 | Metabolic pathways_Homo sapiens_hsa01100 | 0.54525667 |
| 55 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.53706627 |
| 56 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.52427236 |
| 57 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.51362069 |
| 58 | Carbon metabolism_Homo sapiens_hsa01200 | 0.48962394 |
| 59 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.48516075 |
| 60 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.47760697 |
| 61 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.46816006 |
| 62 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.44714567 |
| 63 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.40377376 |
| 64 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.38740664 |
| 65 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.37367972 |
| 66 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.36717641 |
| 67 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.36424790 |
| 68 | HTLV-I infection_Homo sapiens_hsa05166 | 0.36204132 |
| 69 | Sulfur relay system_Homo sapiens_hsa04122 | 0.35085420 |
| 70 | Thyroid cancer_Homo sapiens_hsa05216 | 0.32001191 |
| 71 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.31208937 |
| 72 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.30801690 |
| 73 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.30465118 |
| 74 | Peroxisome_Homo sapiens_hsa04146 | 0.30434660 |
| 75 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.30168374 |
| 76 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.28627271 |
| 77 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.27117864 |
| 78 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.26847234 |
| 79 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.26256371 |
| 80 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.25608003 |
| 81 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.24338106 |
| 82 | Legionellosis_Homo sapiens_hsa05134 | 0.22288356 |
| 83 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.22060522 |
| 84 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.19963725 |
| 85 | Adherens junction_Homo sapiens_hsa04520 | 0.19945758 |
| 86 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.19288840 |
| 87 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.18358645 |
| 88 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.18332399 |
| 89 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.17855542 |
| 90 | Phototransduction_Homo sapiens_hsa04744 | 0.17078770 |
| 91 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.14932943 |
| 92 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.14723385 |
| 93 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.13710532 |
| 94 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.13499775 |
| 95 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.13374073 |
| 96 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.13303290 |
| 97 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.12672782 |
| 98 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.11762545 |
| 99 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.10929803 |
| 100 | Bladder cancer_Homo sapiens_hsa05219 | 0.10522336 |
| 101 | Tight junction_Homo sapiens_hsa04530 | 0.10071901 |
| 102 | Retinol metabolism_Homo sapiens_hsa00830 | 0.09378584 |
| 103 | Galactose metabolism_Homo sapiens_hsa00052 | 0.08531375 |
| 104 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.07115754 |
| 105 | Lysine degradation_Homo sapiens_hsa00310 | 0.06466835 |
| 106 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.06446216 |
| 107 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.05299253 |
| 108 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.04272150 |
| 109 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.04074593 |
| 110 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.03985219 |
| 111 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.03699718 |
| 112 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.03563493 |
| 113 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.03202691 |
| 114 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.03077602 |
| 115 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.02994342 |
| 116 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.02191361 |
| 117 | Shigellosis_Homo sapiens_hsa05131 | 0.01139950 |
| 118 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.00951537 |

