NUDCD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.63541555
2DNA strand elongation involved in DNA replication (GO:0006271)4.60674845
3DNA unwinding involved in DNA replication (GO:0006268)4.51742000
4DNA replication initiation (GO:0006270)4.42858118
5ribosomal small subunit biogenesis (GO:0042274)4.39949736
6DNA strand elongation (GO:0022616)4.33037964
7translational termination (GO:0006415)4.28607303
8viral transcription (GO:0019083)4.27514528
9establishment of integrated proviral latency (GO:0075713)4.26333664
10nucleobase biosynthetic process (GO:0046112)4.25821055
11telomere maintenance via semi-conservative replication (GO:0032201)4.23843652
12purine nucleobase biosynthetic process (GO:0009113)4.22972401
13formation of translation preinitiation complex (GO:0001731)4.16526788
14DNA replication checkpoint (GO:0000076)4.12081447
15ribosomal large subunit biogenesis (GO:0042273)4.10904550
16CENP-A containing nucleosome assembly (GO:0034080)4.02346297
17chromatin remodeling at centromere (GO:0031055)4.01757274
18ribosome assembly (GO:0042255)3.94871552
19telomere maintenance via recombination (GO:0000722)3.93371493
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.90356633
21cotranslational protein targeting to membrane (GO:0006613)3.89729997
22DNA ligation (GO:0006266)3.87788352
23cullin deneddylation (GO:0010388)3.84847574
24mitotic metaphase plate congression (GO:0007080)3.83973275
25protein targeting to ER (GO:0045047)3.83895945
26protein localization to kinetochore (GO:0034501)3.82608225
27ribosomal small subunit assembly (GO:0000028)3.81857838
28non-recombinational repair (GO:0000726)3.81118209
29double-strand break repair via nonhomologous end joining (GO:0006303)3.81118209
30translational elongation (GO:0006414)3.80173320
31translational initiation (GO:0006413)3.78663594
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.78603161
33mitotic recombination (GO:0006312)3.77805513
34ribonucleoprotein complex biogenesis (GO:0022613)3.71336021
35kinetochore organization (GO:0051383)3.70230850
36mitotic sister chromatid segregation (GO:0000070)3.67153642
37establishment of protein localization to endoplasmic reticulum (GO:0072599)3.66273526
38protein localization to endoplasmic reticulum (GO:0070972)3.63946188
39regulation of centriole replication (GO:0046599)3.63450288
40DNA replication-dependent nucleosome organization (GO:0034723)3.61373636
41DNA replication-dependent nucleosome assembly (GO:0006335)3.61373636
42DNA double-strand break processing (GO:0000729)3.61030369
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.60582836
44folic acid-containing compound biosynthetic process (GO:0009396)3.60053766
45nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.58987546
46proteasome assembly (GO:0043248)3.58641104
47nucleotide-excision repair, DNA gap filling (GO:0006297)3.57817899
48rRNA processing (GO:0006364)3.57353621
49DNA replication-independent nucleosome organization (GO:0034724)3.56511364
50DNA replication-independent nucleosome assembly (GO:0006336)3.56511364
51spindle checkpoint (GO:0031577)3.54141756
52spliceosomal snRNP assembly (GO:0000387)3.53337461
53protein deneddylation (GO:0000338)3.53336673
547-methylguanosine mRNA capping (GO:0006370)3.52400057
55sister chromatid segregation (GO:0000819)3.51619648
56anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.51085572
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.50591853
58telomere maintenance via telomere lengthening (GO:0010833)3.48789106
59establishment of protein localization to mitochondrial membrane (GO:0090151)3.48345651
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48340538
61establishment of chromosome localization (GO:0051303)3.48067712
627-methylguanosine RNA capping (GO:0009452)3.46496537
63RNA capping (GO:0036260)3.46496537
64cellular protein complex disassembly (GO:0043624)3.45281081
65mitotic spindle checkpoint (GO:0071174)3.44841154
66rRNA metabolic process (GO:0016072)3.44796177
67mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44758154
68histone exchange (GO:0043486)3.44644779
69establishment of viral latency (GO:0019043)3.44306862
70negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.43089146
71negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.43089146
72negative regulation of mitotic sister chromatid segregation (GO:0033048)3.43089146
73negative regulation of mitotic sister chromatid separation (GO:2000816)3.43089146
74negative regulation of sister chromatid segregation (GO:0033046)3.43089146
75metaphase plate congression (GO:0051310)3.42116628
76viral life cycle (GO:0019058)3.41637609
77transcription-coupled nucleotide-excision repair (GO:0006283)3.41275606
78DNA catabolic process, exonucleolytic (GO:0000738)3.40864767
79regulation of mitotic spindle checkpoint (GO:1903504)3.40419188
80regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.40419188
81negative regulation of chromosome segregation (GO:0051985)3.40139214
82IMP metabolic process (GO:0046040)3.39150730
83negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36963090
84negative regulation of ligase activity (GO:0051352)3.36963090
85pore complex assembly (GO:0046931)3.35101255
86ribosome biogenesis (GO:0042254)3.34838323
87transcription elongation from RNA polymerase III promoter (GO:0006385)3.34745107
88termination of RNA polymerase III transcription (GO:0006386)3.34745107
89translation (GO:0006412)3.33383553
90kinetochore assembly (GO:0051382)3.32909006
91IMP biosynthetic process (GO:0006188)3.32836841
92regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.31740529
93regulation of mitotic metaphase/anaphase transition (GO:0030071)3.31740529
94mitotic sister chromatid cohesion (GO:0007064)3.31292233
95mitotic chromosome condensation (GO:0007076)3.30053996
96regulation of chromosome segregation (GO:0051983)3.29024324
97transcription elongation from RNA polymerase I promoter (GO:0006362)3.28351275
98protein localization to chromosome, centromeric region (GO:0071459)3.27546004
99regulation of helicase activity (GO:0051095)3.27097504
100DNA damage response, detection of DNA damage (GO:0042769)3.26459220
101attachment of spindle microtubules to kinetochore (GO:0008608)3.25248032
102termination of RNA polymerase I transcription (GO:0006363)3.24511983
103mitotic nuclear envelope disassembly (GO:0007077)3.23116565
104nuclear pore organization (GO:0006999)3.22714470
105mitotic spindle assembly checkpoint (GO:0007094)3.21933348
106regulation of mitotic sister chromatid segregation (GO:0033047)3.20210101
107regulation of sister chromatid segregation (GO:0033045)3.20210101
108regulation of mitotic sister chromatid separation (GO:0010965)3.20210101
109DNA topological change (GO:0006265)3.19998035
110DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.19853919
111cell cycle G1/S phase transition (GO:0044843)3.18767141
112G1/S transition of mitotic cell cycle (GO:0000082)3.18767141
113spindle assembly checkpoint (GO:0071173)3.17731477
114maturation of 5.8S rRNA (GO:0000460)3.15913291
115signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.15909175
116intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.15909175
117membrane disassembly (GO:0030397)3.15448878
118nuclear envelope disassembly (GO:0051081)3.15448878
119somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.15409754
120somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.15409754
121isotype switching (GO:0045190)3.15409754
122energy coupled proton transport, down electrochemical gradient (GO:0015985)3.14707106
123ATP synthesis coupled proton transport (GO:0015986)3.14707106
124nuclear pore complex assembly (GO:0051292)3.13912344
125negative regulation of DNA-dependent DNA replication (GO:2000104)3.13807523
126signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13290778
127signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13290778
128signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13290778
129rRNA modification (GO:0000154)3.13275262
130spliceosomal complex assembly (GO:0000245)3.10942893
131regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.10652727
132signal transduction involved in DNA damage checkpoint (GO:0072422)3.10007411
133signal transduction involved in DNA integrity checkpoint (GO:0072401)3.10007411
134tRNA aminoacylation for protein translation (GO:0006418)3.08847615
135replication fork processing (GO:0031297)3.08776756
136cellular component biogenesis (GO:0044085)3.07067987
137tRNA aminoacylation (GO:0043039)3.06886177
138amino acid activation (GO:0043038)3.06886177
139regulation of cellular amino acid metabolic process (GO:0006521)3.06686541
140mitotic G2/M transition checkpoint (GO:0044818)3.05983961
141positive regulation of ligase activity (GO:0051351)3.05642884
142signal transduction involved in cell cycle checkpoint (GO:0072395)3.05304896
143transcription from RNA polymerase I promoter (GO:0006360)3.02771763
144protein complex disassembly (GO:0043241)3.00504859
145positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.00209799
146positive regulation of chromosome segregation (GO:0051984)2.99929253
147regulation of spindle organization (GO:0090224)2.99762228
148folic acid metabolic process (GO:0046655)2.99371139

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.55177622
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.58197927
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.15391607
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.80161417
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.66448751
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.58349443
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41482171
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.23230523
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.19322765
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17667376
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.13878687
12* ETS1_20019798_ChIP-Seq_JURKAT_Human3.07079124
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.00746097
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.98870691
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98019977
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.93839731
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93724033
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.68709821
19* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66259921
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.47766626
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.46190777
22* VDR_23849224_ChIP-Seq_CD4+_Human2.45786511
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45528645
24XRN2_22483619_ChIP-Seq_HELA_Human2.39353492
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32014620
26AR_21909140_ChIP-Seq_LNCAP_Human2.28206572
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.25754951
28ELK1_19687146_ChIP-ChIP_HELA_Human2.21484000
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17330969
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16797141
31* DCP1A_22483619_ChIP-Seq_HELA_Human2.15322201
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11328827
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09863818
34TTF2_22483619_ChIP-Seq_HELA_Human2.06579524
35* FOXP3_21729870_ChIP-Seq_TREG_Human2.06123195
36* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95907835
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95869181
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93675493
39* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91182140
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84699507
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83567266
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.82250094
43GABP_19822575_ChIP-Seq_HepG2_Human1.81838072
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79586664
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77973697
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75260299
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74918453
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66961679
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.65648300
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.55409337
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54925005
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53038483
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51265146
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49296107
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48584410
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39965413
57* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31561191
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.24304885
59KDM5A_27292631_Chip-Seq_BREAST_Human1.22189320
60MYC_18940864_ChIP-ChIP_HL60_Human1.22058596
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21376750
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20986144
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20016513
64ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18723757
65IRF1_19129219_ChIP-ChIP_H3396_Human1.18407745
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16730146
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.12580340
68* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10729695
69CIITA_25753668_ChIP-Seq_RAJI_Human1.10319962
70CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09537786
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08795960
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07928710
73* SOX17_20123909_ChIP-Seq_XEN_Mouse1.05429059
74CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02034997
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01054238
76* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99093747
77TFEB_21752829_ChIP-Seq_HELA_Human0.97699990
78POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96981279
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96955379
80* SALL1_21062744_ChIP-ChIP_HESCs_Human0.94949541
81KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94788246
82ZNF274_21170338_ChIP-Seq_K562_Hela0.91785656
83TP63_19390658_ChIP-ChIP_HaCaT_Human0.91565993
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90901109
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90366424
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87102106
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86553133
88ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86127188
89FUS_26573619_Chip-Seq_HEK293_Human0.84024371
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83713764
91PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81135780
92NANOG_16153702_ChIP-ChIP_HESCs_Human0.79924248
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.79484059
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.78896793
95* VDR_22108803_ChIP-Seq_LS180_Human0.78010108
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77728380
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77269724
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.76985243
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76581852
100EWS_26573619_Chip-Seq_HEK293_Human0.76454633
101SOX2_16153702_ChIP-ChIP_HESCs_Human0.76391989
102NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76239316
103ELF5_23300383_ChIP-Seq_T47D_Human0.75628607
104POU5F1_16153702_ChIP-ChIP_HESCs_Human0.75398855
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.73849330
106CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.73693167
107NANOG_21062744_ChIP-ChIP_HESCs_Human0.73364171
108TCF3_18692474_ChIP-Seq_MEFs_Mouse0.73362038
109NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71319817
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.69260365
111TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68654128
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68054393
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.67042081
114PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.66754009
115TAF15_26573619_Chip-Seq_HEK293_Human0.65712140

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.27115578
2MP0010094_abnormal_chromosome_stability4.75978389
3MP0004957_abnormal_blastocyst_morpholog4.74986473
4MP0003111_abnormal_nucleus_morphology4.06173481
5MP0008057_abnormal_DNA_replication4.04089957
6MP0003077_abnormal_cell_cycle3.81319174
7MP0008058_abnormal_DNA_repair3.33088233
8MP0008932_abnormal_embryonic_tissue3.21751268
9MP0008007_abnormal_cellular_replicative2.63952586
10MP0003123_paternal_imprinting2.62510833
11MP0008877_abnormal_DNA_methylation2.53269562
12MP0001730_embryonic_growth_arrest2.34374567
13MP0003806_abnormal_nucleotide_metabolis2.24601534
14MP0003718_maternal_effect2.17723409
15MP0000350_abnormal_cell_proliferation2.17222687
16MP0003786_premature_aging2.16291305
17MP0009379_abnormal_foot_pigmentation1.97140414
18MP0001529_abnormal_vocalization1.81196764
19MP0003890_abnormal_embryonic-extraembry1.80687415
20MP0000537_abnormal_urethra_morphology1.76322102
21MP0003121_genomic_imprinting1.75679754
22MP0009697_abnormal_copulation1.75379059
23MP0001697_abnormal_embryo_size1.69081514
24MP0003941_abnormal_skin_development1.61711231
25MP0003315_abnormal_perineum_morphology1.55507868
26MP0002396_abnormal_hematopoietic_system1.54148185
27MP0002080_prenatal_lethality1.50492019
28MP0002085_abnormal_embryonic_tissue1.49363309
29MP0010352_gastrointestinal_tract_polyps1.48601894
30MP0005380_embryogenesis_phenotype1.48421051
31MP0001672_abnormal_embryogenesis/_devel1.48421051
32MP0001293_anophthalmia1.45635497
33MP0003937_abnormal_limbs/digits/tail_de1.40950229
34MP0002084_abnormal_developmental_patter1.39411508
35MP0002102_abnormal_ear_morphology1.33789080
36MP0002938_white_spotting1.32817335
37MP0004197_abnormal_fetal_growth/weight/1.32499417
38MP0010307_abnormal_tumor_latency1.31810012
39MP0002210_abnormal_sex_determination1.30606194
40MP0006054_spinal_hemorrhage1.23343391
41MP0010030_abnormal_orbit_morphology1.21313269
42MP0003984_embryonic_growth_retardation1.20019597
43MP0001145_abnormal_male_reproductive1.19275224
44MP0009053_abnormal_anal_canal1.17878328
45MP0002088_abnormal_embryonic_growth/wei1.17772264
46MP0000313_abnormal_cell_death1.17247761
47MP0006035_abnormal_mitochondrial_morpho1.16395963
48MP0000358_abnormal_cell_content/1.15039588
49MP0009672_abnormal_birth_weight1.12739991
50MP0001929_abnormal_gametogenesis1.11300004
51MP0003567_abnormal_fetal_cardiomyocyte1.08773864
52MP0000490_abnormal_crypts_of1.08597450
53MP0002233_abnormal_nose_morphology1.08231442
54MP0004133_heterotaxia1.08137640
55MP0006292_abnormal_olfactory_placode1.07458607
56MP0003221_abnormal_cardiomyocyte_apopto1.06022141
57MP0002234_abnormal_pharynx_morphology1.05850230
58MP0000653_abnormal_sex_gland1.05245954
59MP0002160_abnormal_reproductive_system1.04904136
60MP0006072_abnormal_retinal_apoptosis1.04703617
61MP0001286_abnormal_eye_development1.04103586
62MP0005395_other_phenotype1.02831038
63MP0002019_abnormal_tumor_incidence0.99928719
64MP0002111_abnormal_tail_morphology0.99859573
65MP0000647_abnormal_sebaceous_gland0.98631615
66MP0005408_hypopigmentation0.98351894
67MP0002086_abnormal_extraembryonic_tissu0.98298035
68MP0005501_abnormal_skin_physiology0.96457885
69MP0003186_abnormal_redox_activity0.96328897
70MP0005389_reproductive_system_phenotype0.93266882
71MP0009333_abnormal_splenocyte_physiolog0.88570271
72MP0003136_yellow_coat_color0.88478583
73MP0008789_abnormal_olfactory_epithelium0.88355135
74MP0003938_abnormal_ear_development0.88203107
75MP0003119_abnormal_digestive_system0.82895535
76MP0002796_impaired_skin_barrier0.82017210
77MP0009703_decreased_birth_body0.81385624
78MP0000762_abnormal_tongue_morphology0.81060701
79MP0000566_synostosis0.80004403
80MP0001188_hyperpigmentation0.78592267
81MP0003942_abnormal_urinary_system0.78270765
82MP0002092_abnormal_eye_morphology0.76916699
83MP0002282_abnormal_trachea_morphology0.76708124
84MP0006036_abnormal_mitochondrial_physio0.76378654
85MP0002751_abnormal_autonomic_nervous0.75561393
86MP0000049_abnormal_middle_ear0.74539660
87MP0003698_abnormal_male_reproductive0.74463024
88MP0000579_abnormal_nail_morphology0.73079804
89MP0001881_abnormal_mammary_gland0.72642200
90MP0001119_abnormal_female_reproductive0.72479443
91MP0004272_abnormal_basement_membrane0.69957957
92MP0003861_abnormal_nervous_system0.68918347
93MP0005410_abnormal_fertilization0.68078798
94MP0002006_tumorigenesis0.67019173
95MP0005384_cellular_phenotype0.66051066
96MP0001299_abnormal_eye_distance/0.65631500
97MP0000627_abnormal_mammary_gland0.64215601
98MP0005391_vision/eye_phenotype0.62327399
99MP0000432_abnormal_head_morphology0.61931804
100MP0000428_abnormal_craniofacial_morphol0.61833733
101MP0001905_abnormal_dopamine_level0.61442881
102MP0002254_reproductive_system_inflammat0.61362181
103MP0003950_abnormal_plasma_membrane0.61282727
104MP0003699_abnormal_female_reproductive0.61192397
105MP0001727_abnormal_embryo_implantation0.60890881
106MP0004233_abnormal_muscle_weight0.59621010
107MP0004808_abnormal_hematopoietic_stem0.59447393
108MP0002161_abnormal_fertility/fecundity0.59422193
109MP0005253_abnormal_eye_physiology0.59320916
110MP0002114_abnormal_axial_skeleton0.59279716
111MP0003935_abnormal_craniofacial_develop0.59200739
112MP0002697_abnormal_eye_size0.57323172
113MP0000749_muscle_degeneration0.57043556
114MP0010234_abnormal_vibrissa_follicle0.56617415
115MP0001542_abnormal_bone_strength0.56085474
116MP0000703_abnormal_thymus_morphology0.55905101
117MP0003755_abnormal_palate_morphology0.55772464
118MP0001177_atelectasis0.55521999
119MP0001243_abnormal_dermal_layer0.55006779
120MP0003936_abnormal_reproductive_system0.54801294
121MP0002177_abnormal_outer_ear0.54418598
122MP0001919_abnormal_reproductive_system0.54370722
123MP0005394_taste/olfaction_phenotype0.54265735
124MP0005499_abnormal_olfactory_system0.54265735
125MP0001764_abnormal_homeostasis0.53627599
126MP0005266_abnormal_metabolism0.52390704

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.42104291
2Reticulocytopenia (HP:0001896)4.34146166
3Breast hypoplasia (HP:0003187)4.18881470
4Abnormality of cells of the erythroid lineage (HP:0012130)4.08829519
5Increased serum pyruvate (HP:0003542)3.78615501
6Abnormality of glycolysis (HP:0004366)3.78615501
7Abnormal number of erythroid precursors (HP:0012131)3.43413712
8Acute necrotizing encephalopathy (HP:0006965)3.35888022
9Macrocytic anemia (HP:0001972)3.31121971
10Chromsome breakage (HP:0040012)3.24528114
11Colon cancer (HP:0003003)3.16043397
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.10742065
13Volvulus (HP:0002580)3.07280545
14Oral leukoplakia (HP:0002745)2.98503892
15Abnormal mitochondria in muscle tissue (HP:0008316)2.93562755
16Selective tooth agenesis (HP:0001592)2.87477362
17Pallor (HP:0000980)2.86729381
18Cerebral hypomyelination (HP:0006808)2.84794146
19Stenosis of the external auditory canal (HP:0000402)2.80493125
20Embryonal renal neoplasm (HP:0011794)2.80225897
21Abnormality of the preputium (HP:0100587)2.79592979
22Patellar aplasia (HP:0006443)2.76970894
23Mitochondrial inheritance (HP:0001427)2.76264530
24Absent radius (HP:0003974)2.71239393
25Abnormality of the anterior horn cell (HP:0006802)2.70490600
26Degeneration of anterior horn cells (HP:0002398)2.70490600
27Increased CSF lactate (HP:0002490)2.67778262
28Rough bone trabeculation (HP:0100670)2.66936991
29Hypoplasia of the capital femoral epiphysis (HP:0003090)2.66463601
30Abnormality of methionine metabolism (HP:0010901)2.66150155
31Glossoptosis (HP:0000162)2.65919355
32Abnormality of chromosome stability (HP:0003220)2.62721825
33Increased hepatocellular lipid droplets (HP:0006565)2.62096873
34Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.60013091
35Aplasia/Hypoplasia of the patella (HP:0006498)2.59400677
36Acute encephalopathy (HP:0006846)2.58251061
37Progressive macrocephaly (HP:0004481)2.57147775
38Abnormality of the labia minora (HP:0012880)2.54534812
39Aplasia involving forearm bones (HP:0009822)2.54362031
40Absent forearm bone (HP:0003953)2.54362031
41Meckel diverticulum (HP:0002245)2.48614757
42Abnormality of aspartate family amino acid metabolism (HP:0010899)2.47401093
43Aplastic anemia (HP:0001915)2.45908920
44Increased nuchal translucency (HP:0010880)2.43376724
45Abnormality of the ileum (HP:0001549)2.38283949
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.38152693
47Medulloblastoma (HP:0002885)2.35021051
48Horseshoe kidney (HP:0000085)2.31708174
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31045266
50Agnosia (HP:0010524)2.29272422
51Hypoplasia of the pons (HP:0012110)2.27665767
52Lipid accumulation in hepatocytes (HP:0006561)2.27082944
53Multiple enchondromatosis (HP:0005701)2.25190470
54Abnormality of placental membranes (HP:0011409)2.23584801
55Amniotic constriction ring (HP:0009775)2.23584801
56Abnormality of the pons (HP:0007361)2.22446623
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.21890882
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.21890882
59Congenital ichthyosiform erythroderma (HP:0007431)2.20358875
60Neoplasm of the pancreas (HP:0002894)2.19551662
61Increased serum lactate (HP:0002151)2.18273766
62Hypoplastic pelvis (HP:0008839)2.17527694
63Triphalangeal thumb (HP:0001199)2.16703143
64Cortical dysplasia (HP:0002539)2.15582573
65Abnormality of the carotid arteries (HP:0005344)2.15540567
66Abnormality of serum amino acid levels (HP:0003112)2.15184555
67Type I transferrin isoform profile (HP:0003642)2.12670582
68Glioma (HP:0009733)2.11687310
69Absent thumb (HP:0009777)2.11418285
70Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.11136180
71Absent epiphyses (HP:0010577)2.11136180
72Premature graying of hair (HP:0002216)2.09170798
73Duplicated collecting system (HP:0000081)2.07691656
74Duodenal stenosis (HP:0100867)2.06738497
75Small intestinal stenosis (HP:0012848)2.06738497
76Proximal placement of thumb (HP:0009623)2.05935707
77Hepatocellular necrosis (HP:0001404)2.05763631
783-Methylglutaconic aciduria (HP:0003535)2.05107226
79Reduced antithrombin III activity (HP:0001976)2.03776581
80Atresia of the external auditory canal (HP:0000413)2.03638676
8111 pairs of ribs (HP:0000878)2.03412882
82Myelodysplasia (HP:0002863)2.02388403
83Microretrognathia (HP:0000308)1.99390150
84Supernumerary spleens (HP:0009799)1.99026662
85Microglossia (HP:0000171)1.97571837
86Clubbing of toes (HP:0100760)1.96985254
87Abnormal lung lobation (HP:0002101)1.96846286
88Carpal bone hypoplasia (HP:0001498)1.96159923
89Deviation of the thumb (HP:0009603)1.96077230
90Sparse lateral eyebrow (HP:0005338)1.96060597
91Microvesicular hepatic steatosis (HP:0001414)1.95414943
92Cellular immunodeficiency (HP:0005374)1.92929830
93Abnormal number of incisors (HP:0011064)1.91815702
94Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91804460
95Abnormality of the renal collecting system (HP:0004742)1.91715927
96Hepatic necrosis (HP:0002605)1.91591269
97Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90447582
98Rhabdomyosarcoma (HP:0002859)1.90400868
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89754331
100Abnormal protein N-linked glycosylation (HP:0012347)1.89754331
101Abnormal protein glycosylation (HP:0012346)1.89754331
102Abnormal glycosylation (HP:0012345)1.89754331
103Facial cleft (HP:0002006)1.89066907
104Sloping forehead (HP:0000340)1.88055474
105Exercise intolerance (HP:0003546)1.87862330
106Abnormality of the septum pellucidum (HP:0007375)1.87463085
107Cerebral edema (HP:0002181)1.86852637
108Abnormality of alanine metabolism (HP:0010916)1.86700518
109Hyperalaninemia (HP:0003348)1.86700518
110Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86700518
111Absent septum pellucidum (HP:0001331)1.86069038
112Bone marrow hypocellularity (HP:0005528)1.85526694
113Abnormal trabecular bone morphology (HP:0100671)1.85073792
114Ependymoma (HP:0002888)1.84907495
115Renal Fanconi syndrome (HP:0001994)1.84117799
116Trismus (HP:0000211)1.83631301
117Megaloblastic anemia (HP:0001889)1.81601941
118Irregular epiphyses (HP:0010582)1.81255701
119Neoplasm of the colon (HP:0100273)1.81008047
120Impulsivity (HP:0100710)1.80913102
121Abnormality of the duodenum (HP:0002246)1.80313083
122Septo-optic dysplasia (HP:0100842)1.79810797
123Leukodystrophy (HP:0002415)1.79332648
124Exertional dyspnea (HP:0002875)1.79217766
125Nephroblastoma (Wilms tumor) (HP:0002667)1.78374227
126Postnatal microcephaly (HP:0005484)1.77404853
127Fibular aplasia (HP:0002990)1.77110128
128Shoulder girdle muscle weakness (HP:0003547)1.77093406
129Bifid tongue (HP:0010297)1.76054045
130Lactic acidosis (HP:0003128)1.75776110
131Methylmalonic acidemia (HP:0002912)1.75090813
132Spastic diplegia (HP:0001264)1.73977382
133Abnormalities of placenta or umbilical cord (HP:0001194)1.71758159
134Choanal atresia (HP:0000453)1.70553642
135Astrocytoma (HP:0009592)1.70270212
136Abnormality of the astrocytes (HP:0100707)1.70270212
137Progressive external ophthalmoplegia (HP:0000590)1.69311270
138Short tibia (HP:0005736)1.68333628
139Abnormal auditory evoked potentials (HP:0006958)1.66431432
140Secondary amenorrhea (HP:0000869)1.66301535
141Ovarian neoplasm (HP:0100615)1.65899460
142Sparse eyelashes (HP:0000653)1.63769676

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.65462548
2BUB14.14452402
3CDC73.91009933
4SRPK13.26852652
5EIF2AK13.17105552
6VRK23.01880644
7STK162.59379381
8NME22.56912397
9BRSK22.55007470
10VRK12.53618438
11TSSK62.50443359
12ACVR1B2.32354138
13EIF2AK32.30792133
14TRIM282.05080911
15PNCK2.04759614
16MKNK12.01177861
17PLK31.98079211
18TAF11.93351004
19PLK41.92477578
20TTK1.89446799
21TLK11.84827030
22TESK21.84053230
23PASK1.82215794
24CCNB11.78969710
25PLK11.77486005
26MST41.68764809
27NUAK11.62835517
28AURKB1.60972979
29DYRK31.54676455
30NEK21.53160991
31NEK11.48021080
32PBK1.45399421
33AURKA1.37771382
34BRSK11.37415535
35ATR1.30773849
36RPS6KB21.29307684
37CDK71.27849409
38BCR1.26873411
39LIMK11.24509631
40CHEK21.23161769
41TNIK1.15987994
42TGFBR11.13480601
43EPHA21.13265856
44NME11.11158749
45PDK31.08859385
46PDK41.08859385
47WNK31.01683824
48ZAK0.99144122
49SCYL20.98027858
50CHEK10.95616463
51FLT30.93020679
52MKNK20.92309968
53MAP3K80.91694051
54CSNK1G30.89604725
55BRAF0.84095716
56TESK10.82552315
57CDK80.80851068
58CSNK2A20.79638280
59EIF2AK20.79462154
60TIE10.79253981
61ATM0.76605587
62MAP4K20.75773869
63RPS6KA50.75639796
64CSNK2A10.73693716
65BMPR1B0.73367760
66DYRK20.72572122
67MELK0.71021372
68ALK0.67787023
69RPS6KA40.66720697
70CDK40.63669581
71DAPK10.62988297
72CDK20.62330548
73STK100.61245688
74CLK10.60915148
75CSNK1G10.60711840
76LRRK20.60463496
77PAK10.59013715
78CASK0.58211229
79CDK10.56268438
80STK40.56195819
81PLK20.55842542
82ERBB40.55268863
83LATS10.55139842
84FGFR10.50985547
85ARAF0.49872823
86PRKCI0.48818736
87BRD40.48202067
88LATS20.47242458
89PAK40.47025850
90PDK20.46992903
91MET0.46591598
92CSNK1A1L0.44879567
93MAP3K40.42989308
94PIM20.42326045
95CDK140.41552959
96CSNK1E0.41352229
97NEK90.40431631
98MINK10.40354767
99CSNK1G20.40054952
100CDK180.39247750
101YES10.37699470
102CDK150.37591910
103CDK90.37299138
104MAP2K70.35981144
105CDK11A0.34780477
106STK38L0.32113048
107STK30.30861360
108ERBB30.30380217
109MST1R0.29384580
110CSNK1D0.27303561
111PRKDC0.27259316
112CDK190.24966652
113ILK0.24831809
114ADRBK10.24727257
115ABL20.23055829
116BCKDK0.22690350
117CDK60.21905448
118KDR0.21555908
119NEK60.21307257
120MAP3K120.21031933
121CDK30.20665381
122EGFR0.20211290
123UHMK10.19982864

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.39366831
2Proteasome_Homo sapiens_hsa030504.15112647
3Ribosome_Homo sapiens_hsa030104.11415544
4Mismatch repair_Homo sapiens_hsa034303.88466812
5RNA polymerase_Homo sapiens_hsa030203.71842924
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.45070468
7Spliceosome_Homo sapiens_hsa030403.17405094
8Nucleotide excision repair_Homo sapiens_hsa034202.96939120
9RNA transport_Homo sapiens_hsa030132.91450459
10Homologous recombination_Homo sapiens_hsa034402.81579073
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.60141979
12Pyrimidine metabolism_Homo sapiens_hsa002402.51995148
13One carbon pool by folate_Homo sapiens_hsa006702.51798671
14Protein export_Homo sapiens_hsa030602.44457743
15Cell cycle_Homo sapiens_hsa041102.38328794
16Base excision repair_Homo sapiens_hsa034102.33030492
17Basal transcription factors_Homo sapiens_hsa030222.08624579
18Oxidative phosphorylation_Homo sapiens_hsa001902.08142161
19Non-homologous end-joining_Homo sapiens_hsa034502.05427147
20Fanconi anemia pathway_Homo sapiens_hsa034602.04769573
21Parkinsons disease_Homo sapiens_hsa050121.89072575
22RNA degradation_Homo sapiens_hsa030181.83619712
23Huntingtons disease_Homo sapiens_hsa050161.65627609
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43357530
25Purine metabolism_Homo sapiens_hsa002301.41806998
26Propanoate metabolism_Homo sapiens_hsa006401.38352992
27mRNA surveillance pathway_Homo sapiens_hsa030151.35871957
28p53 signaling pathway_Homo sapiens_hsa041151.35741577
29Systemic lupus erythematosus_Homo sapiens_hsa053221.32426057
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17981244
31Alzheimers disease_Homo sapiens_hsa050101.16460266
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.04864718
33Vitamin B6 metabolism_Homo sapiens_hsa007500.98627373
34Epstein-Barr virus infection_Homo sapiens_hsa051690.98626421
35Oocyte meiosis_Homo sapiens_hsa041140.92572592
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91886598
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90465038
38Cyanoamino acid metabolism_Homo sapiens_hsa004600.87815486
39Glutathione metabolism_Homo sapiens_hsa004800.86160724
40Folate biosynthesis_Homo sapiens_hsa007900.82364150
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82258716
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82011791
43Viral carcinogenesis_Homo sapiens_hsa052030.76083139
44Biosynthesis of amino acids_Homo sapiens_hsa012300.76044067
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71440598
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69532689
47Selenocompound metabolism_Homo sapiens_hsa004500.68134360
48Alcoholism_Homo sapiens_hsa050340.67514823
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64416472
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64306864
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57035584
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56310716
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55564459
54Metabolic pathways_Homo sapiens_hsa011000.54525667
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.53706627
56Steroid biosynthesis_Homo sapiens_hsa001000.52427236
57Pentose phosphate pathway_Homo sapiens_hsa000300.51362069
58Carbon metabolism_Homo sapiens_hsa012000.48962394
59Pyruvate metabolism_Homo sapiens_hsa006200.48516075
60N-Glycan biosynthesis_Homo sapiens_hsa005100.47760697
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46816006
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44714567
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40377376
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38740664
65TGF-beta signaling pathway_Homo sapiens_hsa043500.37367972
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36717641
67Vibrio cholerae infection_Homo sapiens_hsa051100.36424790
68HTLV-I infection_Homo sapiens_hsa051660.36204132
69Sulfur relay system_Homo sapiens_hsa041220.35085420
70Thyroid cancer_Homo sapiens_hsa052160.32001191
71Linoleic acid metabolism_Homo sapiens_hsa005910.31208937
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30801690
73Antigen processing and presentation_Homo sapiens_hsa046120.30465118
74Peroxisome_Homo sapiens_hsa041460.30434660
75Arachidonic acid metabolism_Homo sapiens_hsa005900.30168374
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28627271
77Fatty acid elongation_Homo sapiens_hsa000620.27117864
78Tyrosine metabolism_Homo sapiens_hsa003500.26847234
79Arginine and proline metabolism_Homo sapiens_hsa003300.26256371
80Fatty acid metabolism_Homo sapiens_hsa012120.25608003
81Herpes simplex infection_Homo sapiens_hsa051680.24338106
82Legionellosis_Homo sapiens_hsa051340.22288356
83MicroRNAs in cancer_Homo sapiens_hsa052060.22060522
84Renin-angiotensin system_Homo sapiens_hsa046140.19963725
85Adherens junction_Homo sapiens_hsa045200.19945758
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.19288840
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18358645
88Hippo signaling pathway_Homo sapiens_hsa043900.18332399
89Caffeine metabolism_Homo sapiens_hsa002320.17855542
90Phototransduction_Homo sapiens_hsa047440.17078770
91Basal cell carcinoma_Homo sapiens_hsa052170.14932943
92Hedgehog signaling pathway_Homo sapiens_hsa043400.14723385
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.13710532
94Cardiac muscle contraction_Homo sapiens_hsa042600.13499775
95Ether lipid metabolism_Homo sapiens_hsa005650.13374073
96Phenylalanine metabolism_Homo sapiens_hsa003600.13303290
97Collecting duct acid secretion_Homo sapiens_hsa049660.12672782
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11762545
99Vitamin digestion and absorption_Homo sapiens_hsa049770.10929803
100Bladder cancer_Homo sapiens_hsa052190.10522336
101Tight junction_Homo sapiens_hsa045300.10071901
102Retinol metabolism_Homo sapiens_hsa008300.09378584
103Galactose metabolism_Homo sapiens_hsa000520.08531375
104Butanoate metabolism_Homo sapiens_hsa006500.07115754
105Lysine degradation_Homo sapiens_hsa003100.06466835
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.06446216
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.05299253
108Wnt signaling pathway_Homo sapiens_hsa043100.04272150
109Small cell lung cancer_Homo sapiens_hsa052220.04074593
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.03985219
111Regulation of autophagy_Homo sapiens_hsa041400.03699718
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.03563493
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.03202691
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.03077602
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.02994342
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02191361
117Shigellosis_Homo sapiens_hsa051310.01139950
118Sulfur metabolism_Homo sapiens_hsa009200.00951537

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »