NUDCD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.72840566
2ribosomal small subunit assembly (GO:0000028)4.68933116
3telomere maintenance via semi-conservative replication (GO:0032201)4.55948566
4DNA strand elongation (GO:0022616)4.52215244
5DNA replication initiation (GO:0006270)4.52147959
6maturation of SSU-rRNA (GO:0030490)4.30453591
7formation of translation preinitiation complex (GO:0001731)4.29767924
8nucleobase biosynthetic process (GO:0046112)4.26182260
9ribosomal small subunit biogenesis (GO:0042274)4.23554967
10DNA deamination (GO:0045006)4.23175295
11CENP-A containing nucleosome assembly (GO:0034080)4.21402457
12chromatin remodeling at centromere (GO:0031055)4.17801776
13telomere maintenance via recombination (GO:0000722)4.13458937
14mitotic metaphase plate congression (GO:0007080)4.13131528
15purine nucleobase biosynthetic process (GO:0009113)4.10183540
16viral transcription (GO:0019083)4.09709099
17DNA unwinding involved in DNA replication (GO:0006268)4.07779742
18translational termination (GO:0006415)4.05383580
19ribosomal large subunit biogenesis (GO:0042273)4.03350005
20DNA replication checkpoint (GO:0000076)4.01046287
21mitotic recombination (GO:0006312)3.92773616
22ribosome assembly (GO:0042255)3.90115365
23ribonucleoprotein complex biogenesis (GO:0022613)3.90032000
24kinetochore organization (GO:0051383)3.83105605
25ribosome biogenesis (GO:0042254)3.77425768
26telomere maintenance via telomere lengthening (GO:0010833)3.75969349
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.75268891
28DNA replication-independent nucleosome organization (GO:0034724)3.72145984
29DNA replication-independent nucleosome assembly (GO:0006336)3.72145984
30translational elongation (GO:0006414)3.68441453
31translational initiation (GO:0006413)3.66565036
32IMP biosynthetic process (GO:0006188)3.65162442
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.61556505
34protein localization to kinetochore (GO:0034501)3.60842345
35proteasome assembly (GO:0043248)3.60114674
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.59804981
37replication fork processing (GO:0031297)3.59698302
38DNA replication-dependent nucleosome assembly (GO:0006335)3.59530777
39DNA replication-dependent nucleosome organization (GO:0034723)3.59530777
40respiratory chain complex IV assembly (GO:0008535)3.58498559
41kinetochore assembly (GO:0051382)3.58046239
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56933534
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.56933534
44NADH dehydrogenase complex assembly (GO:0010257)3.56933534
45metaphase plate congression (GO:0051310)3.56683962
46protein complex biogenesis (GO:0070271)3.56646352
47folic acid-containing compound biosynthetic process (GO:0009396)3.55493043
48mitochondrial respiratory chain complex assembly (GO:0033108)3.54307304
49cotranslational protein targeting to membrane (GO:0006613)3.53861827
50spliceosomal snRNP assembly (GO:0000387)3.52053304
51protein targeting to ER (GO:0045047)3.51606565
52mitotic nuclear envelope disassembly (GO:0007077)3.49669389
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.46625087
54rRNA processing (GO:0006364)3.45880628
55negative regulation of DNA-dependent DNA replication (GO:2000104)3.44072662
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.43909196
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.42656113
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.41968044
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41789267
60nuclear pore organization (GO:0006999)3.39602755
61ATP synthesis coupled proton transport (GO:0015986)3.38072118
62energy coupled proton transport, down electrochemical gradient (GO:0015985)3.38072118
63histone exchange (GO:0043486)3.37875546
64rRNA metabolic process (GO:0016072)3.33337558
65DNA double-strand break processing (GO:0000729)3.33255450
66regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.33213041
67establishment of protein localization to endoplasmic reticulum (GO:0072599)3.31859657
68protein localization to endoplasmic reticulum (GO:0070972)3.30181419
69rRNA modification (GO:0000154)3.26040049
70pseudouridine synthesis (GO:0001522)3.25113916
71chaperone-mediated protein transport (GO:0072321)3.23578383
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23156026
73IMP metabolic process (GO:0046040)3.20823134
74protein neddylation (GO:0045116)3.20759428
75nuclear envelope disassembly (GO:0051081)3.20536791
76membrane disassembly (GO:0030397)3.20536791
77translation (GO:0006412)3.20405013
78cellular protein complex disassembly (GO:0043624)3.19757525
79protein localization to chromosome, centromeric region (GO:0071459)3.19594588
80establishment of chromosome localization (GO:0051303)3.19593182
81establishment of integrated proviral latency (GO:0075713)3.18640876
82transcription-coupled nucleotide-excision repair (GO:0006283)3.18463666
83viral life cycle (GO:0019058)3.17627131
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17358009
85peptidyl-histidine modification (GO:0018202)3.16658363
86nuclear pore complex assembly (GO:0051292)3.13714385
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13636343
88cullin deneddylation (GO:0010388)3.12894032
89cytochrome complex assembly (GO:0017004)3.11181828
90positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10315838
91attachment of spindle microtubules to kinetochore (GO:0008608)3.08290135
92regulation of mitotic spindle checkpoint (GO:1903504)3.07061379
93regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.07061379
94centriole replication (GO:0007099)3.05224316
95termination of RNA polymerase III transcription (GO:0006386)3.04858760
96transcription elongation from RNA polymerase III promoter (GO:0006385)3.04858760
97regulation of spindle organization (GO:0090224)3.03479478
98G1/S transition of mitotic cell cycle (GO:0000082)3.01093984
99cell cycle G1/S phase transition (GO:0044843)3.01093984
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99705695
101DNA damage response, detection of DNA damage (GO:0042769)2.98913291
102protein K6-linked ubiquitination (GO:0085020)2.97386827
103cellular component biogenesis (GO:0044085)2.97380267
104negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95827926
105negative regulation of ligase activity (GO:0051352)2.95827926
106water-soluble vitamin biosynthetic process (GO:0042364)2.95662625
107regulation of nuclear cell cycle DNA replication (GO:0033262)2.95032995
108mitotic sister chromatid segregation (GO:0000070)2.93787624
109viral mRNA export from host cell nucleus (GO:0046784)2.93147463
110resolution of meiotic recombination intermediates (GO:0000712)2.92868811
111spliceosomal complex assembly (GO:0000245)2.91743128
112telomere organization (GO:0032200)2.91393924
113telomere maintenance (GO:0000723)2.90357871
114rRNA methylation (GO:0031167)2.90043928
115maturation of 5.8S rRNA (GO:0000460)2.90023483
116respiratory electron transport chain (GO:0022904)2.89738752
117electron transport chain (GO:0022900)2.88717459
118spindle checkpoint (GO:0031577)2.88291889
119regulation of helicase activity (GO:0051095)2.87626901
120recombinational repair (GO:0000725)2.87085288
121protein-cofactor linkage (GO:0018065)2.86474883
122negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86211597
123negative regulation of sister chromatid segregation (GO:0033046)2.86211597
124negative regulation of mitotic sister chromatid separation (GO:2000816)2.86211597
125negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86211597
1267-methylguanosine mRNA capping (GO:0006370)2.86063433
127protein deneddylation (GO:0000338)2.85862091
128protein complex disassembly (GO:0043241)2.85555740
129negative regulation of chromosome segregation (GO:0051985)2.85155519
1307-methylguanosine RNA capping (GO:0009452)2.83193806
131RNA capping (GO:0036260)2.83193806
132double-strand break repair via homologous recombination (GO:0000724)2.82853799
133histone mRNA metabolic process (GO:0008334)2.81398798
134regulation of double-strand break repair via homologous recombination (GO:0010569)2.81279952
135regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.81237633
136nuclear-transcribed mRNA catabolic process (GO:0000956)2.81233597
137meiotic chromosome segregation (GO:0045132)2.81210215
138regulation of DNA endoreduplication (GO:0032875)2.80480552
139DNA catabolic process, exonucleolytic (GO:0000738)2.79768602
140mitochondrial RNA metabolic process (GO:0000959)2.77384231
141DNA ligation (GO:0006266)2.76886880
142RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.74588693
143mitotic spindle checkpoint (GO:0071174)2.73560483
144tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73226747
145RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73226747
146negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.72267861
147synapsis (GO:0007129)2.71726072
148sister chromatid segregation (GO:0000819)2.65233007
149regulation of mitochondrial translation (GO:0070129)2.64278905
150DNA-dependent DNA replication (GO:0006261)2.61232851
151somatic hypermutation of immunoglobulin genes (GO:0016446)2.59994425
152somatic diversification of immune receptors via somatic mutation (GO:0002566)2.59994425
153reciprocal DNA recombination (GO:0035825)2.59685325
154reciprocal meiotic recombination (GO:0007131)2.59685325
155transcription from mitochondrial promoter (GO:0006390)2.58641061
156tRNA processing (GO:0008033)2.58089853
157mitotic spindle assembly checkpoint (GO:0007094)2.57365461
158spindle assembly checkpoint (GO:0071173)2.55452868
159microtubule depolymerization (GO:0007019)2.50000562
160regulation of centriole replication (GO:0046599)2.49927232

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.16064359
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.58837063
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.63476556
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.60311258
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55651137
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.54379223
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.17811111
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.16547874
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.15925474
10* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05668554
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.01031851
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.99677792
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94569393
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.88142549
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.83205257
16VDR_22108803_ChIP-Seq_LS180_Human2.67788929
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57199908
18ZNF274_21170338_ChIP-Seq_K562_Hela2.55252257
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.52108020
20EWS_26573619_Chip-Seq_HEK293_Human2.52029566
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43789972
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.37585555
23* XRN2_22483619_ChIP-Seq_HELA_Human2.35566148
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31781310
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.29273319
26* VDR_23849224_ChIP-Seq_CD4+_Human2.27508821
27FUS_26573619_Chip-Seq_HEK293_Human2.24607358
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20506056
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15550277
30* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13845373
31DCP1A_22483619_ChIP-Seq_HELA_Human2.12106096
32AR_21909140_ChIP-Seq_LNCAP_Human2.05526103
33POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05499050
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02458193
35IGF1R_20145208_ChIP-Seq_DFB_Human2.00323351
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00129258
37FOXP3_21729870_ChIP-Seq_TREG_Human1.98050187
38ELK1_19687146_ChIP-ChIP_HELA_Human1.89375936
39TTF2_22483619_ChIP-Seq_HELA_Human1.87550430
40* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87253895
41TAF15_26573619_Chip-Seq_HEK293_Human1.83844931
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.82832129
43* GABP_19822575_ChIP-Seq_HepG2_Human1.81581423
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77578701
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76417659
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74945149
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74545339
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.73577433
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73325038
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71461379
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70094323
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66797180
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65701879
54* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63611649
55P300_19829295_ChIP-Seq_ESCs_Human1.59790979
56* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56325323
57* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55365408
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.54004005
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53085765
60* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52427729
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51944114
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.51835773
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51560986
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51192921
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47362837
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.44739748
67IRF1_19129219_ChIP-ChIP_H3396_Human1.39948186
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39059780
69GBX2_23144817_ChIP-Seq_PC3_Human1.38660335
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38048886
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35117726
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33500018
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32427809
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31949804
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30356362
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30203004
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29688511
78KDM5A_27292631_Chip-Seq_BREAST_Human1.28644296
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27441216
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27216487
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24466709
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23961378
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23434311
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23167558
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22054248
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21895582
87* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21061448
88TP53_22573176_ChIP-Seq_HFKS_Human1.19338201
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19313280
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18943372
91CIITA_25753668_ChIP-Seq_RAJI_Human1.17583843
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17493715
93TFEB_21752829_ChIP-Seq_HELA_Human1.16743144
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16050808
95SOX2_16153702_ChIP-ChIP_HESCs_Human1.14747898
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.14184441
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13546820
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11473251
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11247362
100ER_23166858_ChIP-Seq_MCF-7_Human1.10545201
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09616675
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08769174
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08473448
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08473448
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08473448
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07748841
107TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05613847
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05057898
109ELK1_22589737_ChIP-Seq_MCF10A_Human1.04215568
110NANOG_16153702_ChIP-ChIP_HESCs_Human1.03649313
111MYC_18940864_ChIP-ChIP_HL60_Human1.03272533
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03175999
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00934952
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00220279
115CBP_20019798_ChIP-Seq_JUKART_Human1.00220279
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00013976
117NANOG_19829295_ChIP-Seq_ESCs_Human0.99623794
118SOX2_19829295_ChIP-Seq_ESCs_Human0.99623794
119NOTCH1_21737748_ChIP-Seq_TLL_Human0.96776207
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96657702
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96644044
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94473155
123SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93587055
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.92016027
125* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91397914
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89858250
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89626757
128RNF2_27304074_Chip-Seq_NSC_Mouse0.88696799
129* SOX17_20123909_ChIP-Seq_XEN_Mouse0.87907615
130FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86492535
131FOXA1_25329375_ChIP-Seq_VCAP_Human0.86492535
132GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86357081
133DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86230808
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85809511
135KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85356725
136SALL1_21062744_ChIP-ChIP_HESCs_Human0.84952790
137* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84754556
138CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84202806
139MYC_22102868_ChIP-Seq_BL_Human0.84122884
140OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83230594
141NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81411748
142CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79819244
143SPI1_23547873_ChIP-Seq_NB4_Human0.79675611

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.31457081
2MP0003111_abnormal_nucleus_morphology4.37610726
3MP0004957_abnormal_blastocyst_morpholog4.34890341
4MP0010094_abnormal_chromosome_stability4.30719757
5MP0003077_abnormal_cell_cycle3.85508364
6MP0008057_abnormal_DNA_replication3.80976436
7MP0008058_abnormal_DNA_repair3.38565092
8MP0008007_abnormal_cellular_replicative2.93326228
9MP0008932_abnormal_embryonic_tissue2.84489033
10MP0003806_abnormal_nucleotide_metabolis2.70723916
11MP0003123_paternal_imprinting2.24522379
12MP0006072_abnormal_retinal_apoptosis2.19654510
13MP0001730_embryonic_growth_arrest2.06944983
14MP0000350_abnormal_cell_proliferation2.03637040
15MP0003786_premature_aging2.00471576
16MP0002396_abnormal_hematopoietic_system1.93179686
17MP0004147_increased_porphyrin_level1.91802966
18MP0010352_gastrointestinal_tract_polyps1.87890634
19MP0010030_abnormal_orbit_morphology1.85467428
20MP0003718_maternal_effect1.84100922
21MP0000569_abnormal_digit_pigmentation1.70438492
22MP0001529_abnormal_vocalization1.69789188
23MP0002234_abnormal_pharynx_morphology1.64334177
24MP0000490_abnormal_crypts_of1.63940191
25MP0010307_abnormal_tumor_latency1.60550762
26MP0005253_abnormal_eye_physiology1.58432062
27MP0003186_abnormal_redox_activity1.58102898
28MP0003136_yellow_coat_color1.55728591
29MP0008789_abnormal_olfactory_epithelium1.55438601
30MP0005551_abnormal_eye_electrophysiolog1.55352546
31MP0002638_abnormal_pupillary_reflex1.55333214
32MP0003941_abnormal_skin_development1.53679055
33MP0005380_embryogenesis_phenotype1.51640450
34MP0001672_abnormal_embryogenesis/_devel1.51640450
35MP0001697_abnormal_embryo_size1.51183593
36MP0002736_abnormal_nociception_after1.49954341
37MP0000631_abnormal_neuroendocrine_gland1.44943166
38MP0003195_calcinosis1.43696935
39MP0005084_abnormal_gallbladder_morpholo1.43635384
40MP0005646_abnormal_pituitary_gland1.43197960
41MP0006035_abnormal_mitochondrial_morpho1.42637198
42MP0002837_dystrophic_cardiac_calcinosis1.41863181
43MP0004133_heterotaxia1.39375372
44MP0002080_prenatal_lethality1.39026050
45MP0002085_abnormal_embryonic_tissue1.38757114
46MP0006292_abnormal_olfactory_placode1.37988296
47MP0008877_abnormal_DNA_methylation1.36702388
48MP0003315_abnormal_perineum_morphology1.36409395
49MP0003880_abnormal_central_pattern1.35789715
50MP0000313_abnormal_cell_death1.34738530
51MP0004197_abnormal_fetal_growth/weight/1.30977649
52MP0003787_abnormal_imprinting1.29508140
53MP0003984_embryonic_growth_retardation1.27480166
54MP0002019_abnormal_tumor_incidence1.27304090
55MP0002088_abnormal_embryonic_growth/wei1.24080991
56MP0002084_abnormal_developmental_patter1.23910024
57MP0001485_abnormal_pinna_reflex1.22971626
58MP0009333_abnormal_splenocyte_physiolog1.22709906
59MP0009379_abnormal_foot_pigmentation1.20711205
60MP0003890_abnormal_embryonic-extraembry1.20545118
61MP0004142_abnormal_muscle_tone1.20131083
62MP0005394_taste/olfaction_phenotype1.19581615
63MP0005499_abnormal_olfactory_system1.19581615
64MP0001293_anophthalmia1.19202126
65MP0001968_abnormal_touch/_nociception1.19179278
66MP0002086_abnormal_extraembryonic_tissu1.15649566
67MP0001764_abnormal_homeostasis1.14034626
68MP0001984_abnormal_olfaction1.13034385
69MP0003567_abnormal_fetal_cardiomyocyte1.12596167
70MP0000427_abnormal_hair_cycle1.12558334
71MP0002210_abnormal_sex_determination1.12480437
72MP0000647_abnormal_sebaceous_gland1.10901666
73MP0002132_abnormal_respiratory_system1.10773555
74MP0009046_muscle_twitch1.10250145
75MP0003937_abnormal_limbs/digits/tail_de1.09389956
76MP0002095_abnormal_skin_pigmentation1.09167207
77MP0002751_abnormal_autonomic_nervous1.07479747
78MP0002160_abnormal_reproductive_system1.07241331
79MP0006054_spinal_hemorrhage1.07227353
80MP0006276_abnormal_autonomic_nervous1.05798493
81MP0002233_abnormal_nose_morphology1.03585756
82MP0000537_abnormal_urethra_morphology1.03443948
83MP0002111_abnormal_tail_morphology1.02624984
84MP0003121_genomic_imprinting1.01456007
85MP0000566_synostosis1.01329280
86MP0001145_abnormal_male_reproductive1.00896677
87MP0008872_abnormal_physiological_respon1.00186351
88MP0009053_abnormal_anal_canal0.96735514
89MP0005391_vision/eye_phenotype0.96364640
90MP0005645_abnormal_hypothalamus_physiol0.96190321
91MP0005174_abnormal_tail_pigmentation0.95296476
92MP0004885_abnormal_endolymph0.95153879
93MP0005187_abnormal_penis_morphology0.93566601
94MP0002938_white_spotting0.92505935
95MP0001919_abnormal_reproductive_system0.92503984
96MP0003698_abnormal_male_reproductive0.92159131
97MP0002163_abnormal_gland_morphology0.91969783
98MP0000858_altered_metastatic_potential0.91842170
99MP0004808_abnormal_hematopoietic_stem0.91383950
100MP0003011_delayed_dark_adaptation0.90708620
101MP0004215_abnormal_myocardial_fiber0.89598643
102MP0000778_abnormal_nervous_system0.89009600
103MP0001986_abnormal_taste_sensitivity0.88762617
104MP0009697_abnormal_copulation0.87673882
105MP0005367_renal/urinary_system_phenotyp0.87325546
106MP0000516_abnormal_urinary_system0.87325546
107MP0001188_hyperpigmentation0.86663984
108MP0008995_early_reproductive_senescence0.86640074
109MP0005389_reproductive_system_phenotype0.86025149
110MP0000653_abnormal_sex_gland0.84018636
111MP0005195_abnormal_posterior_eye0.81447936
112MP0003122_maternal_imprinting0.80672078
113MP0004043_abnormal_pH_regulation0.78753252
114MP0001286_abnormal_eye_development0.78741684
115MP0001119_abnormal_female_reproductive0.78147548
116MP0005397_hematopoietic_system_phenotyp0.77117331
117MP0001545_abnormal_hematopoietic_system0.77117331
118MP0001929_abnormal_gametogenesis0.77067438
119MP0000358_abnormal_cell_content/0.76150411
120MP0003119_abnormal_digestive_system0.75494958
121MP0002272_abnormal_nervous_system0.75182966
122MP0005395_other_phenotype0.74360241
123MP0005023_abnormal_wound_healing0.74326055
124MP0001486_abnormal_startle_reflex0.73783324
125MP0002722_abnormal_immune_system0.72369274
126MP0009745_abnormal_behavioral_response0.72026036
127MP0005075_abnormal_melanosome_morpholog0.71162655
128MP0001853_heart_inflammation0.70708225
129MP0005408_hypopigmentation0.70390757
130MP0000372_irregular_coat_pigmentation0.70273611
131MP0002102_abnormal_ear_morphology0.69947729
132MP0002282_abnormal_trachea_morphology0.69804086
133MP0001915_intracranial_hemorrhage0.68926740
134MP0000689_abnormal_spleen_morphology0.68520179
135MP0000703_abnormal_thymus_morphology0.68372557
136MP0003763_abnormal_thymus_physiology0.66585663
137MP0009672_abnormal_birth_weight0.66208695
138MP0005384_cellular_phenotype0.64440055
139MP0005076_abnormal_cell_differentiation0.64241642
140MP0002398_abnormal_bone_marrow0.63450647
141MP0005266_abnormal_metabolism0.63209089
142MP0000049_abnormal_middle_ear0.62929795
143MP0002092_abnormal_eye_morphology0.61148656
144MP0002653_abnormal_ependyma_morphology0.60847750
145MP0000428_abnormal_craniofacial_morphol0.59281060
146MP0002429_abnormal_blood_cell0.57864995
147MP0000477_abnormal_intestine_morphology0.57706496
148MP0000432_abnormal_head_morphology0.57581557
149MP0006036_abnormal_mitochondrial_physio0.56589128
150MP0005621_abnormal_cell_physiology0.55291025
151MP0001186_pigmentation_phenotype0.55190173
152MP0005501_abnormal_skin_physiology0.54578844
153MP0002277_abnormal_respiratory_mucosa0.53618891
154MP0003755_abnormal_palate_morphology0.53487015
155MP0003936_abnormal_reproductive_system0.53443829
156MP0003221_abnormal_cardiomyocyte_apopto0.53205690

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.81398379
2Birth length less than 3rd percentile (HP:0003561)4.73494064
3Abnormality of cells of the erythroid lineage (HP:0012130)4.47356083
4Breast hypoplasia (HP:0003187)4.29144086
5Abnormal number of erythroid precursors (HP:0012131)4.21842986
6Chromsome breakage (HP:0040012)3.87957468
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.73076188
8Acute necrotizing encephalopathy (HP:0006965)3.68943299
9Pancreatic cysts (HP:0001737)3.53457352
10Oral leukoplakia (HP:0002745)3.46197697
11Molar tooth sign on MRI (HP:0002419)3.36303802
12Abnormality of midbrain morphology (HP:0002418)3.36303802
13Pancreatic fibrosis (HP:0100732)3.34712449
14Acute encephalopathy (HP:0006846)3.33250206
15Macrocytic anemia (HP:0001972)3.28515622
16Carpal bone hypoplasia (HP:0001498)3.26973648
17True hermaphroditism (HP:0010459)3.25212466
18Mitochondrial inheritance (HP:0001427)3.24543118
19Increased CSF lactate (HP:0002490)3.24070988
20Abnormal mitochondria in muscle tissue (HP:0008316)3.22446675
21Colon cancer (HP:0003003)3.18099906
22Rough bone trabeculation (HP:0100670)3.17522342
23Progressive macrocephaly (HP:0004481)3.14011935
24Meckel diverticulum (HP:0002245)3.09892360
25Patellar aplasia (HP:0006443)3.03467228
26Selective tooth agenesis (HP:0001592)3.02870148
27Aplastic anemia (HP:0001915)3.00141984
28Pallor (HP:0000980)2.99844120
29Abnormality of chromosome stability (HP:0003220)2.96900554
30Absent radius (HP:0003974)2.96514743
31Abnormality of the ileum (HP:0001549)2.94645948
32Lipid accumulation in hepatocytes (HP:0006561)2.87363765
33Aplasia/Hypoplasia of the patella (HP:0006498)2.86543078
34Abnormality of the preputium (HP:0100587)2.81254353
35Cerebral hypomyelination (HP:0006808)2.80239217
36Absent thumb (HP:0009777)2.79708217
37Hepatocellular necrosis (HP:0001404)2.79331717
38Aplasia involving forearm bones (HP:0009822)2.77651223
39Absent forearm bone (HP:0003953)2.77651223
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.75715144
41Duplicated collecting system (HP:0000081)2.74525218
42Nephronophthisis (HP:0000090)2.74384766
43Abnormality of the anterior horn cell (HP:0006802)2.70670618
44Degeneration of anterior horn cells (HP:0002398)2.70670618
45Hepatic necrosis (HP:0002605)2.69122357
4611 pairs of ribs (HP:0000878)2.65054162
473-Methylglutaconic aciduria (HP:0003535)2.61672916
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.59806884
49Medulloblastoma (HP:0002885)2.59250751
50Premature graying of hair (HP:0002216)2.58322834
51Abnormality of alanine metabolism (HP:0010916)2.58316803
52Hyperalaninemia (HP:0003348)2.58316803
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58316803
54Medial flaring of the eyebrow (HP:0010747)2.56281507
55Cerebral edema (HP:0002181)2.52329353
56Trismus (HP:0000211)2.51588404
57Agnosia (HP:0010524)2.50925473
58Volvulus (HP:0002580)2.48743730
59Duodenal stenosis (HP:0100867)2.46788009
60Small intestinal stenosis (HP:0012848)2.46788009
61Bone marrow hypocellularity (HP:0005528)2.44293264
62Supernumerary spleens (HP:0009799)2.42978069
63Irregular epiphyses (HP:0010582)2.42624664
64Abnormal lung lobation (HP:0002101)2.41214830
65Abnormality of the renal collecting system (HP:0004742)2.37689500
66Abnormal trabecular bone morphology (HP:0100671)2.36848610
67Hyperglycinemia (HP:0002154)2.35748737
68Triphalangeal thumb (HP:0001199)2.34692288
69Microretrognathia (HP:0000308)2.32151213
70Renal Fanconi syndrome (HP:0001994)2.30914084
71Neoplasm of the pancreas (HP:0002894)2.30571803
72Multiple enchondromatosis (HP:0005701)2.30060397
73Sclerocornea (HP:0000647)2.29706411
74Myelodysplasia (HP:0002863)2.28943331
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.26846345
76Impulsivity (HP:0100710)2.25608251
77Glossoptosis (HP:0000162)2.25470092
78Abnormality of the renal medulla (HP:0100957)2.25122812
79Methylmalonic acidemia (HP:0002912)2.21414866
80Horseshoe kidney (HP:0000085)2.19606538
81Type I transferrin isoform profile (HP:0003642)2.18136962
82Stenosis of the external auditory canal (HP:0000402)2.17095279
83Abnormal number of incisors (HP:0011064)2.13780290
84Microvesicular hepatic steatosis (HP:0001414)2.13694755
85Abnormality of the renal cortex (HP:0011035)2.13298992
86Lactic acidosis (HP:0003128)2.13284340
87Abnormality of the duodenum (HP:0002246)2.10777902
88Sloping forehead (HP:0000340)2.10183821
89Aplasia/Hypoplasia of the tongue (HP:0010295)2.09517811
90Abnormal biliary tract physiology (HP:0012439)2.09430815
91Bile duct proliferation (HP:0001408)2.09430815
92Tracheoesophageal fistula (HP:0002575)2.08483613
93Abnormality of pyrimidine metabolism (HP:0004353)2.08242139
94Chronic hepatic failure (HP:0100626)2.07808273
95Congenital primary aphakia (HP:0007707)2.05846712
96Missing ribs (HP:0000921)2.02433259
97Anencephaly (HP:0002323)2.02222048
98Abnormality of the pons (HP:0007361)2.01415560
99Abnormality of serum amino acid levels (HP:0003112)2.01148123
100Aplasia/Hypoplasia of the tibia (HP:0005772)2.00981590
101Pancytopenia (HP:0001876)1.99988430
102Type II lissencephaly (HP:0007260)1.99494023
103Ectopic kidney (HP:0000086)1.98290892
104Renal cortical cysts (HP:0000803)1.97553531
105Cleft eyelid (HP:0000625)1.97239617
106Cystic liver disease (HP:0006706)1.96706162
107Pendular nystagmus (HP:0012043)1.96427945
108Cellular immunodeficiency (HP:0005374)1.96111793
109Gait imbalance (HP:0002141)1.95713987
110Poor head control (HP:0002421)1.95674524
111Atresia of the external auditory canal (HP:0000413)1.95306423
112Hypoplasia of the pons (HP:0012110)1.94940891
113Secondary amenorrhea (HP:0000869)1.94803312
114Megaloblastic anemia (HP:0001889)1.94517550
115Congenital, generalized hypertrichosis (HP:0004540)1.94140083
116Congenital stationary night blindness (HP:0007642)1.93805351
117Thrombocytosis (HP:0001894)1.93189885
118Optic disc pallor (HP:0000543)1.90736722
119Abnormality of the labia minora (HP:0012880)1.90300675
120Short thumb (HP:0009778)1.90254730
121Hypoplasia of the radius (HP:0002984)1.90180771
122Asplenia (HP:0001746)1.89496482
123Hyperglycinuria (HP:0003108)1.88959432
124Rhabdomyosarcoma (HP:0002859)1.88877162
125Increased serum lactate (HP:0002151)1.87152194
126Septo-optic dysplasia (HP:0100842)1.86799975
127Genital tract atresia (HP:0001827)1.86025272
128Nephrogenic diabetes insipidus (HP:0009806)1.86021754
129Preaxial hand polydactyly (HP:0001177)1.85627002
130Methylmalonic aciduria (HP:0012120)1.84772688
131Postaxial foot polydactyly (HP:0001830)1.84646238
132Abnormality of the umbilical cord (HP:0010881)1.84279262
133Exertional dyspnea (HP:0002875)1.83618257
134Ependymoma (HP:0002888)1.83391682
135Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83379829
136Abnormal protein N-linked glycosylation (HP:0012347)1.83379829
137Abnormal protein glycosylation (HP:0012346)1.83379829
138Abnormal glycosylation (HP:0012345)1.83379829
139Intestinal atresia (HP:0011100)1.82794833
140Vaginal atresia (HP:0000148)1.81592366
141Ureteral duplication (HP:0000073)1.81151591
142Leukodystrophy (HP:0002415)1.80220294
143Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79923474
144Abnormality of glycine metabolism (HP:0010895)1.79365333
145Abnormality of serine family amino acid metabolism (HP:0010894)1.79365333
146Abnormal umbilical cord blood vessels (HP:0011403)1.77682856
147Single umbilical artery (HP:0001195)1.77682856
148Abnormality of the fetal cardiovascular system (HP:0010948)1.77682856
149Premature ovarian failure (HP:0008209)1.77347385
150Sparse eyelashes (HP:0000653)1.76739612
151Increased hepatocellular lipid droplets (HP:0006565)1.75805827
152Abnormality of reticulocytes (HP:0004312)1.75497319
153Increased intramyocellular lipid droplets (HP:0012240)1.73807466
154Respiratory failure (HP:0002878)1.73799784
155Short tibia (HP:0005736)1.73552663
156Lethargy (HP:0001254)1.73388516
157Slender long bone (HP:0003100)1.73117271
158Dandy-Walker malformation (HP:0001305)1.72631145
159Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72439795
160Male pseudohermaphroditism (HP:0000037)1.72169453
161Squamous cell carcinoma (HP:0002860)1.72015389
162Abnormality of methionine metabolism (HP:0010901)1.71741256
163Aplasia/Hypoplasia of the spleen (HP:0010451)1.69986341
164Nephroblastoma (Wilms tumor) (HP:0002667)1.69504745
165Exercise intolerance (HP:0003546)1.68913117
166Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.68554469
167Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.68418104
168Decreased activity of mitochondrial respiratory chain (HP:0008972)1.68418104
169Adrenal hypoplasia (HP:0000835)1.68055346
170Lymphoma (HP:0002665)1.67777441
171Facial cleft (HP:0002006)1.67685726
172Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67364774
173Aplasia/Hypoplasia involving the musculature (HP:0001460)1.66781310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.72484774
2WEE14.09824355
3CDC73.24743830
4EIF2AK13.23383661
5SRPK12.98509035
6NME22.90280495
7STK162.87500263
8FRK2.76046289
9BMPR1B2.69289655
10VRK22.44370780
11TTK2.38622200
12PLK42.38064284
13NUAK12.35561402
14EIF2AK32.32176868
15NEK22.24690908
16BRSK22.16505314
17TRIM282.14494475
18MKNK12.09961426
19TNIK2.03985192
20TLK11.98675690
21VRK11.96461543
22PLK11.96164954
23TSSK61.93391700
24PBK1.85401452
25MAP4K21.84528498
26TESK21.84184043
27DYRK31.74700257
28ACVR1B1.73585559
29WNK31.72449463
30EPHA21.71586283
31ZAK1.68456663
32PASK1.67155886
33CDK71.64290300
34RPS6KB21.63632941
35NEK11.62642337
36AURKB1.62624484
37PLK31.57582583
38MKNK21.54716240
39ATR1.49263801
40SCYL21.45729162
41GRK11.43346982
42AURKA1.38051823
43PIM21.34701335
44CHEK21.33709716
45RPS6KA41.30560453
46PNCK1.24581042
47ADRBK21.21815878
48CASK1.20606122
49MAP3K81.19690666
50BRSK11.14674288
51MAP3K41.08895184
52PINK11.08412858
53EIF2AK21.08290448
54WNK41.06879844
55MAPK131.06597961
56INSRR1.06144278
57STK391.05079860
58TGFBR11.04700317
59STK41.04684634
60STK101.02293073
61CHEK11.02115106
62CDK41.01018343
63PDK20.98190421
64PLK20.96409332
65MST40.94844402
66PAK40.94740460
67OXSR10.94664301
68TAF10.89382272
69CSNK1G10.87721714
70CDK190.86988678
71CSNK1G20.83866786
72TESK10.81949622
73PIM10.76744748
74CCNB10.76201209
75FLT30.75781789
76TAOK30.75540160
77ATM0.74447487
78CSNK2A10.74145934
79CSNK2A20.73481519
80CDK120.72181667
81BRAF0.71904602
82RPS6KA50.70744502
83KDR0.69037269
84STK38L0.68476632
85CLK10.68182454
86CDK20.66687563
87PAK10.66284821
88MAP2K70.65371409
89EPHA40.65198696
90CSNK1A1L0.64718023
91DYRK20.64334309
92LIMK10.63698608
93CDK80.63462764
94BCKDK0.60896840
95PRKCG0.59895622
96TAOK20.57612374
97MELK0.56746560
98MAP3K30.56571305
99MAP2K30.56381605
100IRAK40.56055269
101PRKCI0.54115876
102PAK30.51744536
103CDK10.51583953
104CDK60.49232702
105MET0.48307137
106TEC0.47741078
107BRD40.46910675
108NME10.46685850
109STK30.46411253
110MAP3K110.45938025
111YES10.45163553
112PRKCE0.44748360
113PKN10.44418929
114LRRK20.42002195
115ADRBK10.41416659
116ABL20.41333518
117ALK0.40782955
118MAPKAPK30.39035215
119TIE10.38747171
120MAPKAPK50.37419837
121CDK30.35287672
122NEK90.34368696
123ERBB40.33527667
124IKBKB0.33192674
125FGFR10.31729138
126CSNK1A10.31179279
127ERBB30.31077672
128IRAK30.30662594
129CSNK1E0.27296361
130BTK0.27114921
131MINK10.25716177
132AKT20.24858311
133CSNK1G30.24603113
134CAMK2A0.24511726
135BLK0.23621996
136AKT30.21758267
137PRKDC0.21676505
138PAK20.18375871
139BCR0.17198432
140NLK0.16910821
141CSNK1D0.15461838
142MAPKAPK20.15382391

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.70514238
2Mismatch repair_Homo sapiens_hsa034303.99159258
3Ribosome_Homo sapiens_hsa030103.96949942
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.46856114
5Proteasome_Homo sapiens_hsa030503.45369327
6RNA polymerase_Homo sapiens_hsa030203.29213029
7Spliceosome_Homo sapiens_hsa030403.18291350
8Homologous recombination_Homo sapiens_hsa034402.97191951
9RNA transport_Homo sapiens_hsa030132.86794880
10Base excision repair_Homo sapiens_hsa034102.78377124
11Nucleotide excision repair_Homo sapiens_hsa034202.77551896
12One carbon pool by folate_Homo sapiens_hsa006702.73809583
13Pyrimidine metabolism_Homo sapiens_hsa002402.56037647
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.42123855
15Cell cycle_Homo sapiens_hsa041102.35087399
16Fanconi anemia pathway_Homo sapiens_hsa034602.20919329
17Non-homologous end-joining_Homo sapiens_hsa034502.09403892
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02739552
19Basal transcription factors_Homo sapiens_hsa030221.97659139
20Propanoate metabolism_Homo sapiens_hsa006401.92296964
21RNA degradation_Homo sapiens_hsa030181.76860017
22p53 signaling pathway_Homo sapiens_hsa041151.60123079
23Alzheimers disease_Homo sapiens_hsa050101.52285714
24Protein export_Homo sapiens_hsa030601.51145392
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50049392
26Butanoate metabolism_Homo sapiens_hsa006501.42907226
27mRNA surveillance pathway_Homo sapiens_hsa030151.37928101
28Purine metabolism_Homo sapiens_hsa002301.36236449
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32820440
30Systemic lupus erythematosus_Homo sapiens_hsa053221.24501853
31Folate biosynthesis_Homo sapiens_hsa007901.17765334
32Pyruvate metabolism_Homo sapiens_hsa006201.17633453
33Fatty acid elongation_Homo sapiens_hsa000621.10411341
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06112247
35Phototransduction_Homo sapiens_hsa047441.05021688
36Epstein-Barr virus infection_Homo sapiens_hsa051691.04144758
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.00909317
38Peroxisome_Homo sapiens_hsa041461.00901132
39Nitrogen metabolism_Homo sapiens_hsa009100.97801758
40Cardiac muscle contraction_Homo sapiens_hsa042600.96833049
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96184301
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.95572157
43Selenocompound metabolism_Homo sapiens_hsa004500.94628032
44Sulfur relay system_Homo sapiens_hsa041220.91475598
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.91083589
46Glutathione metabolism_Homo sapiens_hsa004800.88535595
47Tryptophan metabolism_Homo sapiens_hsa003800.84734529
48Caffeine metabolism_Homo sapiens_hsa002320.83594103
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81562694
50Pentose phosphate pathway_Homo sapiens_hsa000300.81444195
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80552975
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80323843
53Biosynthesis of amino acids_Homo sapiens_hsa012300.78107882
54Sulfur metabolism_Homo sapiens_hsa009200.77038049
55Herpes simplex infection_Homo sapiens_hsa051680.77000357
56Vitamin B6 metabolism_Homo sapiens_hsa007500.76550893
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76337345
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74448275
59Viral carcinogenesis_Homo sapiens_hsa052030.73722503
60Nicotine addiction_Homo sapiens_hsa050330.73444342
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72964416
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72177155
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.71168940
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.70499547
65Huntingtons disease_Homo sapiens_hsa050160.68836792
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67466492
67Chemical carcinogenesis_Homo sapiens_hsa052040.64618442
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64585673
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63276812
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63116587
71Legionellosis_Homo sapiens_hsa051340.62638518
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61618695
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61326768
74Olfactory transduction_Homo sapiens_hsa047400.61041274
75beta-Alanine metabolism_Homo sapiens_hsa004100.60959653
76Fatty acid metabolism_Homo sapiens_hsa012120.60110760
77Antigen processing and presentation_Homo sapiens_hsa046120.60029615
78Parkinsons disease_Homo sapiens_hsa050120.58569720
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56117033
80Regulation of autophagy_Homo sapiens_hsa041400.54117637
81Oocyte meiosis_Homo sapiens_hsa041140.53945971
82Steroid biosynthesis_Homo sapiens_hsa001000.51391278
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51343151
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.51139854
85HTLV-I infection_Homo sapiens_hsa051660.50908657
86Fatty acid degradation_Homo sapiens_hsa000710.50806483
87Oxidative phosphorylation_Homo sapiens_hsa001900.50702204
88Arachidonic acid metabolism_Homo sapiens_hsa005900.49359432
89Arginine and proline metabolism_Homo sapiens_hsa003300.44180865
90Carbon metabolism_Homo sapiens_hsa012000.43757346
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42821037
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42370331
93Metabolic pathways_Homo sapiens_hsa011000.41314074
94Taste transduction_Homo sapiens_hsa047420.41064487
95N-Glycan biosynthesis_Homo sapiens_hsa005100.40977489
96Ether lipid metabolism_Homo sapiens_hsa005650.39624100
97Small cell lung cancer_Homo sapiens_hsa052220.38128828
98MicroRNAs in cancer_Homo sapiens_hsa052060.36891270
99Hedgehog signaling pathway_Homo sapiens_hsa043400.36217607
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35463672
101TGF-beta signaling pathway_Homo sapiens_hsa043500.34984431
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34053530
103Linoleic acid metabolism_Homo sapiens_hsa005910.33628079
104Thyroid cancer_Homo sapiens_hsa052160.32980801
105Apoptosis_Homo sapiens_hsa042100.32632608
106Basal cell carcinoma_Homo sapiens_hsa052170.31220681
107Fat digestion and absorption_Homo sapiens_hsa049750.31183649
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30999708
109Collecting duct acid secretion_Homo sapiens_hsa049660.30930129
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30794899
111Hippo signaling pathway_Homo sapiens_hsa043900.28988357
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28579239
113Alcoholism_Homo sapiens_hsa050340.28230562
114Asthma_Homo sapiens_hsa053100.27312886
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26233484
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.23760205
117Measles_Homo sapiens_hsa051620.23604548
118Renin-angiotensin system_Homo sapiens_hsa046140.22365574
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22291355
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20588728
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20584210
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20519144
123Other glycan degradation_Homo sapiens_hsa005110.19014134
124Galactose metabolism_Homo sapiens_hsa000520.18959524
125Shigellosis_Homo sapiens_hsa051310.18458873
126Fructose and mannose metabolism_Homo sapiens_hsa000510.18163209
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18085221
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17714025
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17117945
130Hematopoietic cell lineage_Homo sapiens_hsa046400.16577210
131Bladder cancer_Homo sapiens_hsa052190.15929797
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15875405
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.14433719
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14085266
135Vitamin digestion and absorption_Homo sapiens_hsa049770.13924946
136Hepatitis B_Homo sapiens_hsa051610.13544306
137Primary immunodeficiency_Homo sapiens_hsa053400.12974911
138Allograft rejection_Homo sapiens_hsa053300.12369722
139Retinol metabolism_Homo sapiens_hsa008300.11959135

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