NUDT10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.72196427
2vocalization behavior (GO:0071625)5.15441784
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.03602376
4protein localization to synapse (GO:0035418)4.87711294
5presynaptic membrane assembly (GO:0097105)4.80159456
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.70347188
7synaptic vesicle exocytosis (GO:0016079)4.64970671
8neurotransmitter-gated ion channel clustering (GO:0072578)4.57980035
9regulation of glutamate receptor signaling pathway (GO:1900449)4.50999311
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.41032705
11presynaptic membrane organization (GO:0097090)4.38172680
12postsynaptic membrane organization (GO:0001941)4.36850566
13regulation of synaptic vesicle exocytosis (GO:2000300)4.36707707
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.22963416
15neuron recognition (GO:0008038)4.21610425
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.21267615
17negative regulation of synaptic transmission, GABAergic (GO:0032229)4.15817267
18glutamate secretion (GO:0014047)4.14865540
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.08069515
20glutamate receptor signaling pathway (GO:0007215)3.99175871
21neuronal action potential propagation (GO:0019227)3.91776005
22regulation of synaptic vesicle transport (GO:1902803)3.83916635
23synaptic transmission, glutamatergic (GO:0035249)3.83558707
24neurotransmitter secretion (GO:0007269)3.78706652
25neuron-neuron synaptic transmission (GO:0007270)3.75398041
26axonal fasciculation (GO:0007413)3.71784575
27gamma-aminobutyric acid signaling pathway (GO:0007214)3.66903743
28positive regulation of synapse assembly (GO:0051965)3.65798489
29locomotory exploration behavior (GO:0035641)3.65078653
30regulation of glutamate secretion (GO:0014048)3.63639498
31positive regulation of synapse maturation (GO:0090129)3.60340070
32DNA double-strand break processing (GO:0000729)3.54268966
33synaptic vesicle docking involved in exocytosis (GO:0016081)3.51549365
34exploration behavior (GO:0035640)3.49467817
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47523437
36pyrimidine nucleobase catabolic process (GO:0006208)3.47257990
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.46629906
38proline transport (GO:0015824)3.42712999
39synaptic vesicle maturation (GO:0016188)3.39320721
40cerebellar granule cell differentiation (GO:0021707)3.38747371
41behavioral response to nicotine (GO:0035095)3.37784415
42regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.36227371
43layer formation in cerebral cortex (GO:0021819)3.36146694
44regulation of neuronal synaptic plasticity (GO:0048168)3.35394898
45gamma-aminobutyric acid transport (GO:0015812)3.34311085
46synapse assembly (GO:0007416)3.33442292
47transmission of nerve impulse (GO:0019226)3.33419760
48cell migration in hindbrain (GO:0021535)3.31520937
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.28132425
50neurotransmitter transport (GO:0006836)3.27956806
51long-term synaptic potentiation (GO:0060291)3.27226010
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.26476738
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.25264410
54regulation of postsynaptic membrane potential (GO:0060078)3.22712439
55regulation of synapse structural plasticity (GO:0051823)3.21597338
56response to histamine (GO:0034776)3.20592849
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.19471062
58positive regulation of synaptic transmission, GABAergic (GO:0032230)3.17996202
59DNA damage response, detection of DNA damage (GO:0042769)3.17363259
60nonmotile primary cilium assembly (GO:0035058)3.16088064
61establishment of mitochondrion localization (GO:0051654)3.16061521
62dendritic spine morphogenesis (GO:0060997)3.12074106
63regulation of development, heterochronic (GO:0040034)3.11606283
64olfactory bulb development (GO:0021772)3.08237120
65startle response (GO:0001964)3.08110224
66regulation of respiratory system process (GO:0044065)3.07030643
67negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06806507
68chromatin remodeling at centromere (GO:0031055)3.06489976
69chaperone-mediated protein transport (GO:0072321)3.05678159
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.05382132
71innervation (GO:0060384)3.04988706
72regulation of synapse assembly (GO:0051963)3.04825221
73protein neddylation (GO:0045116)3.04577689
74sequestering of actin monomers (GO:0042989)3.04194005
75regulation of synapse maturation (GO:0090128)3.03549644
76seminiferous tubule development (GO:0072520)3.03452111
77female mating behavior (GO:0060180)3.02104438
78long-term memory (GO:0007616)3.01323449
79positive regulation of amino acid transport (GO:0051957)3.00486083
80regulation of synaptic plasticity (GO:0048167)3.00454433
81positive regulation of membrane potential (GO:0045838)2.99712212
82dendrite development (GO:0016358)2.99290855
83cerebral cortex radially oriented cell migration (GO:0021799)2.98193707
84auditory behavior (GO:0031223)2.97226513
85regulation of vesicle fusion (GO:0031338)2.95639184
86regulation of neurotransmitter secretion (GO:0046928)2.95278284
87mechanosensory behavior (GO:0007638)2.94916169
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94273519
89synaptic vesicle endocytosis (GO:0048488)2.93738207
90learning (GO:0007612)2.92941966
91nucleobase catabolic process (GO:0046113)2.92696937
92regulation of neurotransmitter levels (GO:0001505)2.91721318
93behavioral defense response (GO:0002209)2.90378999
94behavioral fear response (GO:0001662)2.90378999
95negative regulation of dendrite morphogenesis (GO:0050774)2.89072121
96regulation of synaptic transmission, GABAergic (GO:0032228)2.87728871
97forebrain neuron differentiation (GO:0021879)2.87232857
98regulation of female receptivity (GO:0045924)2.87148023
99intraciliary transport (GO:0042073)2.84916300
100response to auditory stimulus (GO:0010996)2.84805449
101negative regulation of dendrite development (GO:2000171)2.84690637
102fear response (GO:0042596)2.83633358
103synapse organization (GO:0050808)2.82831042
104positive regulation of male gonad development (GO:2000020)2.81866465
105CENP-A containing nucleosome assembly (GO:0034080)2.81306464
106negative regulation of neurotransmitter transport (GO:0051589)2.81084044
107limb bud formation (GO:0060174)2.79140536
108dendrite morphogenesis (GO:0048813)2.79028831
109regulation of neurotransmitter transport (GO:0051588)2.78735565
110striatum development (GO:0021756)2.78487871
111regulation of timing of cell differentiation (GO:0048505)2.77990238
112synaptic transmission (GO:0007268)2.77659053
113negative regulation of amino acid transport (GO:0051956)2.77270308
114membrane depolarization (GO:0051899)2.77178508
115negative regulation of DNA recombination (GO:0045910)2.76705735
116regulation of synapse organization (GO:0050807)2.75830341
117membrane hyperpolarization (GO:0060081)2.75330269
118ATP hydrolysis coupled proton transport (GO:0015991)2.75226292
119somite development (GO:0061053)2.74321260
120epithelial cilium movement (GO:0003351)2.74240504
121central nervous system projection neuron axonogenesis (GO:0021952)2.72168286
122calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.70887480
123somatic hypermutation of immunoglobulin genes (GO:0016446)2.66533617
124somatic diversification of immune receptors via somatic mutation (GO:0002566)2.66533617
125negative regulation of transcription regulatory region DNA binding (GO:2000678)2.62159957
126chaperone-mediated protein complex assembly (GO:0051131)2.61808871
127cullin deneddylation (GO:0010388)2.59609649
128retinal ganglion cell axon guidance (GO:0031290)2.57399846
129C4-dicarboxylate transport (GO:0015740)2.55185584
130neurofilament cytoskeleton organization (GO:0060052)2.54918497
131histone exchange (GO:0043486)2.52877912
132short-term memory (GO:0007614)2.48837923
133regulation of mitotic spindle checkpoint (GO:1903504)2.47512039
134regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.47512039
135DNA replication-independent nucleosome assembly (GO:0006336)2.44875259
136DNA replication-independent nucleosome organization (GO:0034724)2.44875259
137spinal cord development (GO:0021510)2.43534481
138hippocampus development (GO:0021766)2.43087286
139L-serine metabolic process (GO:0006563)2.41088803
140epithelial cell differentiation involved in kidney development (GO:0035850)2.37871388
141protein deneddylation (GO:0000338)2.37715682
142anterograde axon cargo transport (GO:0008089)2.37587011
143resolution of meiotic recombination intermediates (GO:0000712)2.35387597
144establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.35084260
145mitochondrion transport along microtubule (GO:0047497)2.35084260
146neuron fate determination (GO:0048664)2.34308476
147regulation of male gonad development (GO:2000018)2.32907956
148ubiquinone metabolic process (GO:0006743)2.32766927
149protein polyglutamylation (GO:0018095)2.32761208
150establishment of integrated proviral latency (GO:0075713)2.30506554
151regulation of meiosis I (GO:0060631)2.30429879
152positive regulation of dendritic spine morphogenesis (GO:0061003)2.29464172
153microtubule depolymerization (GO:0007019)2.28996874
154cell fate commitment involved in formation of primary germ layer (GO:0060795)2.28584098
155head development (GO:0060322)2.27858603
156establishment of protein localization to mitochondrial membrane (GO:0090151)2.24707775
157centriole replication (GO:0007099)2.24476316
158regulation of cilium movement (GO:0003352)2.24453333
159otic vesicle formation (GO:0030916)2.23296610
160negative regulation of DNA-dependent DNA replication (GO:2000104)2.21487964
161protein-cofactor linkage (GO:0018065)2.21323005
162histone H2A acetylation (GO:0043968)2.20934737
163regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.18775219
164DNA integration (GO:0015074)2.17811285
165DNA ligation (GO:0006266)2.16322667
166cilium movement (GO:0003341)2.15113506
167negative regulation of glial cell differentiation (GO:0045686)2.14362541
168regulation of feeding behavior (GO:0060259)2.14321741
169RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.14318206
170tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.14318206
171neuromuscular synaptic transmission (GO:0007274)2.13987894
172spermatid nucleus differentiation (GO:0007289)2.12883748
173mRNA splice site selection (GO:0006376)2.12426044

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.81004412
2GBX2_23144817_ChIP-Seq_PC3_Human4.13680358
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07767732
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96518680
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90349805
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.72873643
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56834326
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56368415
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56122046
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54740513
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54740513
12REST_21632747_ChIP-Seq_MESCs_Mouse2.48795794
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.48347473
14TAF15_26573619_Chip-Seq_HEK293_Human2.48321864
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47747800
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.44536491
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39563979
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26488393
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25412605
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20991498
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20709455
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.19445014
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16212749
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.14131681
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13955184
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.09074562
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07230167
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06012227
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04940709
30BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03792532
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01353236
32REST_18959480_ChIP-ChIP_MESCs_Mouse2.00233623
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99102038
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.96701724
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86053924
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.85908369
37P300_19829295_ChIP-Seq_ESCs_Human1.84751074
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84375029
39AR_21572438_ChIP-Seq_LNCaP_Human1.81011371
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.80850497
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.78036925
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77416697
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76473003
44SMAD4_21799915_ChIP-Seq_A2780_Human1.74314201
45* RNF2_27304074_Chip-Seq_NSC_Mouse1.71931238
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70297607
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69703133
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.68923685
49ZNF274_21170338_ChIP-Seq_K562_Hela1.66923098
50SOX2_16153702_ChIP-ChIP_HESCs_Human1.64495044
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62684451
52MYC_18940864_ChIP-ChIP_HL60_Human1.62521985
53FUS_26573619_Chip-Seq_HEK293_Human1.59732947
54GATA1_26923725_Chip-Seq_HPCs_Mouse1.57608614
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57437151
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53983145
57DROSHA_22980978_ChIP-Seq_HELA_Human1.50644047
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49982475
59IGF1R_20145208_ChIP-Seq_DFB_Human1.49885862
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.49042394
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48423482
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.48411005
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47893959
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47546274
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45092235
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40386061
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.39963628
68ELK1_19687146_ChIP-ChIP_HELA_Human1.37069976
69VDR_22108803_ChIP-Seq_LS180_Human1.35855545
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35644542
71AR_25329375_ChIP-Seq_VCAP_Human1.35380303
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.35192916
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.33216920
74IRF1_19129219_ChIP-ChIP_H3396_Human1.33115758
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28142716
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27437138
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.26842895
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.24252349
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.23608171
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.23326412
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22175236
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21742544
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21316597
84STAT3_23295773_ChIP-Seq_U87_Human1.18651871
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18107018
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17445347
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17145077
88ER_23166858_ChIP-Seq_MCF-7_Human1.17129939
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16401059
90RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15977277
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15694661
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15155467
93* RUNX2_22187159_ChIP-Seq_PCA_Human1.13740768
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.13648571
95ETS1_20019798_ChIP-Seq_JURKAT_Human1.09846554
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09605466
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09096811
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08443844
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.08370422
100MYC_18555785_ChIP-Seq_MESCs_Mouse1.07328736
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06771262
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.06766704
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06275166
104TCF4_23295773_ChIP-Seq_U87_Human1.06186468
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05955169
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05210591
107AR_19668381_ChIP-Seq_PC3_Human1.04746028
108* JUN_21703547_ChIP-Seq_K562_Human1.04371061
109AHR_22903824_ChIP-Seq_MCF-7_Human1.03467409
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.03169813
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01423747
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01101171
113* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00476040
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00324689
115SOX9_26525672_Chip-Seq_HEART_Mouse1.00145056
116TP53_18474530_ChIP-ChIP_U2OS_Human1.00050776
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99043282
118CBP_20019798_ChIP-Seq_JUKART_Human0.99043282
119POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98369436
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97898050
121POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97534329
122EWS_26573619_Chip-Seq_HEK293_Human0.96977600
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96319122
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96319122
125YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95393463
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95340032
127KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95022533
128VDR_23849224_ChIP-Seq_CD4+_Human0.94331084
129YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94051342
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.93978973
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93861845
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92819655
133RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92476577
134SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92079078
135BCAT_22108803_ChIP-Seq_LS180_Human0.92061637
136E2F1_18555785_Chip-Seq_ESCs_Mouse0.91901219
137TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91510613
138MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90408291
139CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90158634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.27565699
2MP0004859_abnormal_synaptic_plasticity4.49633022
3MP0003635_abnormal_synaptic_transmissio3.52678906
4MP0004270_analgesia3.44871566
5MP0009745_abnormal_behavioral_response3.03694552
6MP0002063_abnormal_learning/memory/cond2.95318767
7MP0001968_abnormal_touch/_nociception2.89793693
8MP0006276_abnormal_autonomic_nervous2.84762222
9MP0002064_seizures2.79906519
10MP0005423_abnormal_somatic_nervous2.78010024
11MP0002572_abnormal_emotion/affect_behav2.66374344
12MP0009046_muscle_twitch2.56425748
13MP0008877_abnormal_DNA_methylation2.52199985
14MP0002736_abnormal_nociception_after2.48033794
15MP0002734_abnormal_mechanical_nocicepti2.42679616
16MP0002272_abnormal_nervous_system2.40998473
17MP0000778_abnormal_nervous_system2.35805517
18MP0001529_abnormal_vocalization2.34661796
19MP0003122_maternal_imprinting2.33064626
20MP0001440_abnormal_grooming_behavior2.29916788
21MP0001486_abnormal_startle_reflex2.27772583
22MP0002822_catalepsy2.24785418
23MP0003890_abnormal_embryonic-extraembry2.23607195
24MP0002735_abnormal_chemical_nociception2.18283082
25MP0005645_abnormal_hypothalamus_physiol2.12391196
26MP0002184_abnormal_innervation2.03734162
27MP0001501_abnormal_sleep_pattern1.99349644
28MP0002733_abnormal_thermal_nociception1.97363880
29MP0002067_abnormal_sensory_capabilities1.96386555
30MP0004133_heterotaxia1.88891801
31MP0002557_abnormal_social/conspecific_i1.86518612
32MP0001188_hyperpigmentation1.85652485
33MP0005646_abnormal_pituitary_gland1.83676997
34MP0001293_anophthalmia1.83203851
35MP0001970_abnormal_pain_threshold1.81422626
36MP0005386_behavior/neurological_phenoty1.72024026
37MP0004924_abnormal_behavior1.72024026
38MP0000049_abnormal_middle_ear1.71121291
39MP0008995_early_reproductive_senescence1.70949519
40MP0001984_abnormal_olfaction1.63163181
41MP0004858_abnormal_nervous_system1.62214224
42MP0003567_abnormal_fetal_cardiomyocyte1.61023763
43MP0003787_abnormal_imprinting1.56927944
44MP0004142_abnormal_muscle_tone1.55182163
45MP0008058_abnormal_DNA_repair1.53555130
46MP0003119_abnormal_digestive_system1.52828713
47MP0001905_abnormal_dopamine_level1.49799876
48MP0002638_abnormal_pupillary_reflex1.47504644
49MP0002882_abnormal_neuron_morphology1.45433297
50MP0000955_abnormal_spinal_cord1.44901159
51MP0002233_abnormal_nose_morphology1.40737808
52MP0004811_abnormal_neuron_physiology1.37987765
53MP0001502_abnormal_circadian_rhythm1.35552681
54MP0002066_abnormal_motor_capabilities/c1.33492465
55MP0004885_abnormal_endolymph1.32148303
56MP0002938_white_spotting1.30432476
57MP0003937_abnormal_limbs/digits/tail_de1.28394320
58MP0003329_amyloid_beta_deposits1.28194608
59MP0008569_lethality_at_weaning1.27779654
60MP0009780_abnormal_chondrocyte_physiolo1.27248384
61MP0003693_abnormal_embryo_hatching1.27032863
62MP0000631_abnormal_neuroendocrine_gland1.22726405
63MP0010030_abnormal_orbit_morphology1.22564220
64MP0002152_abnormal_brain_morphology1.21408301
65MP0002234_abnormal_pharynx_morphology1.18370394
66MP0005171_absent_coat_pigmentation1.18241553
67MP0004742_abnormal_vestibular_system1.14410772
68MP0001286_abnormal_eye_development1.14262973
69MP0010094_abnormal_chromosome_stability1.13686328
70MP0005394_taste/olfaction_phenotype1.13592253
71MP0005499_abnormal_olfactory_system1.13592253
72MP0000569_abnormal_digit_pigmentation1.12892879
73MP0002909_abnormal_adrenal_gland1.12138871
74MP0008932_abnormal_embryonic_tissue1.10940746
75MP0000751_myopathy1.09925181
76MP0003879_abnormal_hair_cell1.09707767
77MP0004145_abnormal_muscle_electrophysio1.06997826
78MP0003123_paternal_imprinting1.06709090
79MP0003121_genomic_imprinting1.06216557
80MP0002697_abnormal_eye_size1.03679486
81MP0002837_dystrophic_cardiac_calcinosis1.02970662
82MP0010386_abnormal_urinary_bladder1.00319194
83MP0005248_abnormal_Harderian_gland0.99725054
84MP0005551_abnormal_eye_electrophysiolog0.99689594
85MP0002751_abnormal_autonomic_nervous0.99516512
86MP0002752_abnormal_somatic_nervous0.99508600
87MP0003315_abnormal_perineum_morphology0.98344239
88MP0001963_abnormal_hearing_physiology0.95579194
89MP0002876_abnormal_thyroid_physiology0.95427844
90MP0006292_abnormal_olfactory_placode0.92712709
91MP0005391_vision/eye_phenotype0.92090023
92MP0003755_abnormal_palate_morphology0.91762579
93MP0002069_abnormal_eating/drinking_beha0.90464719
94MP0000566_synostosis0.90424667
95MP0003634_abnormal_glial_cell0.89169878
96MP0000026_abnormal_inner_ear0.89109880
97MP0001177_atelectasis0.89046687
98MP0002210_abnormal_sex_determination0.88826417
99MP0005195_abnormal_posterior_eye0.88807424
100MP0001485_abnormal_pinna_reflex0.87543249
101MP0001299_abnormal_eye_distance/0.87403781
102MP0002081_perinatal_lethality0.85146635
103MP0003011_delayed_dark_adaptation0.84236722
104MP0002102_abnormal_ear_morphology0.83225340
105MP0003938_abnormal_ear_development0.82913943
106MP0003633_abnormal_nervous_system0.82457859
107MP0002229_neurodegeneration0.82142265
108MP0004085_abnormal_heartbeat0.81607714
109MP0008789_abnormal_olfactory_epithelium0.81537232
110MP0003861_abnormal_nervous_system0.80043419
111MP0006072_abnormal_retinal_apoptosis0.79841364
112MP0003631_nervous_system_phenotype0.79576241
113MP0003942_abnormal_urinary_system0.78280163
114MP0005409_darkened_coat_color0.77698379
115MP0003115_abnormal_respiratory_system0.77476546
116MP0003221_abnormal_cardiomyocyte_apopto0.76827129
117MP0003698_abnormal_male_reproductive0.76101097
118MP0002653_abnormal_ependyma_morphology0.75889486
119MP0009672_abnormal_birth_weight0.75697582
120MP0005187_abnormal_penis_morphology0.75615405
121MP0001943_abnormal_respiration0.70048151
122MP0008872_abnormal_physiological_respon0.66606671
123MP0003137_abnormal_impulse_conducting0.66016995
124MP0000013_abnormal_adipose_tissue0.65904601
125MP0001986_abnormal_taste_sensitivity0.64578961
126MP0005535_abnormal_body_temperature0.64083224
127MP0005253_abnormal_eye_physiology0.63021119
128MP0004484_altered_response_of0.62927174
129MP0001664_abnormal_digestion0.62359921
130MP0003632_abnormal_nervous_system0.60579290
131MP0003183_abnormal_peptide_metabolism0.60207661
132MP0003385_abnormal_body_wall0.59192503
133MP0004215_abnormal_myocardial_fiber0.56629761
134MP0003136_yellow_coat_color0.55170613
135MP0002082_postnatal_lethality0.54643473
136MP0010770_preweaning_lethality0.54643473
137MP0004233_abnormal_muscle_weight0.52458592

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.30736196
2Myokymia (HP:0002411)4.87111123
3Atonic seizures (HP:0010819)4.56722630
4Focal seizures (HP:0007359)4.44737153
5Epileptic encephalopathy (HP:0200134)4.44048945
6Febrile seizures (HP:0002373)4.15113643
7Hyperventilation (HP:0002883)4.09196564
8Absence seizures (HP:0002121)3.48704206
9True hermaphroditism (HP:0010459)3.45317133
10Progressive cerebellar ataxia (HP:0002073)3.35887213
11Dialeptic seizures (HP:0011146)3.28962493
12Gait imbalance (HP:0002141)3.25643955
13Septo-optic dysplasia (HP:0100842)3.25031092
14Limb dystonia (HP:0002451)3.15824429
15Broad-based gait (HP:0002136)3.08041121
16Generalized tonic-clonic seizures (HP:0002069)3.05877251
17Colon cancer (HP:0003003)3.03886456
18Cortical dysplasia (HP:0002539)3.00744974
19Amblyopia (HP:0000646)2.98242299
20Visual hallucinations (HP:0002367)2.97483418
21Abnormal hair whorl (HP:0010721)2.90284656
22Medial flaring of the eyebrow (HP:0010747)2.90107286
23Polyphagia (HP:0002591)2.89030850
24Congenital primary aphakia (HP:0007707)2.82154774
25Retinal dysplasia (HP:0007973)2.71167243
26Abnormal eating behavior (HP:0100738)2.69721877
27Excessive salivation (HP:0003781)2.68345118
28Drooling (HP:0002307)2.68345118
29Nephrogenic diabetes insipidus (HP:0009806)2.65702616
30Abnormal ciliary motility (HP:0012262)2.63549941
31Pheochromocytoma (HP:0002666)2.63396371
32Hyperglycinemia (HP:0002154)2.63330804
33Failure to thrive in infancy (HP:0001531)2.62109146
34Abnormal lung lobation (HP:0002101)2.56072263
35Nephronophthisis (HP:0000090)2.53612818
36Volvulus (HP:0002580)2.50662713
37Anxiety (HP:0000739)2.48061145
38Genital tract atresia (HP:0001827)2.46921642
39Absent speech (HP:0001344)2.46863359
40Protruding tongue (HP:0010808)2.46844222
41Specific learning disability (HP:0001328)2.44851493
42Vaginal atresia (HP:0000148)2.44318654
43Acute necrotizing encephalopathy (HP:0006965)2.44208862
44Pancreatic fibrosis (HP:0100732)2.42558737
45Male pseudohermaphroditism (HP:0000037)2.42048148
46Epileptiform EEG discharges (HP:0011182)2.41976967
47Molar tooth sign on MRI (HP:0002419)2.41528258
48Abnormality of midbrain morphology (HP:0002418)2.41528258
49Dysdiadochokinesis (HP:0002075)2.39561454
50Impaired vibration sensation in the lower limbs (HP:0002166)2.38073574
51Abnormal respiratory motile cilium physiology (HP:0012261)2.37808968
52Abnormality of the corticospinal tract (HP:0002492)2.34410562
53Poor eye contact (HP:0000817)2.33908547
54Hypoplasia of the brainstem (HP:0002365)2.32612879
55Aplasia/Hypoplasia of the brainstem (HP:0007362)2.32612879
56Neuroendocrine neoplasm (HP:0100634)2.30726704
57Depression (HP:0000716)2.30058198
58Hyperthyroidism (HP:0000836)2.28598169
59Abnormal mitochondria in muscle tissue (HP:0008316)2.28587670
60Hypothermia (HP:0002045)2.28552603
61Diplopia (HP:0000651)2.27272104
62Abnormality of binocular vision (HP:0011514)2.27272104
63Truncal ataxia (HP:0002078)2.26278162
64Aplasia/Hypoplasia of the sternum (HP:0006714)2.25418534
65Progressive inability to walk (HP:0002505)2.23744899
66Lissencephaly (HP:0001339)2.23492101
67Optic nerve hypoplasia (HP:0000609)2.22612456
68Pancreatic cysts (HP:0001737)2.21712622
69EEG with generalized epileptiform discharges (HP:0011198)2.21388984
70Hemiparesis (HP:0001269)2.18893596
71Agitation (HP:0000713)2.18520266
72Action tremor (HP:0002345)2.17826400
73Progressive macrocephaly (HP:0004481)2.17534497
74Esotropia (HP:0000565)2.17350729
75Pendular nystagmus (HP:0012043)2.16882789
76Sleep apnea (HP:0010535)2.15864262
77Supranuclear gaze palsy (HP:0000605)2.15048083
78Gaze-evoked nystagmus (HP:0000640)2.14378238
79Gonadal dysgenesis (HP:0000133)2.13870043
80Termporal pattern (HP:0011008)2.12415488
81Insidious onset (HP:0003587)2.12415488
82Poor suck (HP:0002033)2.11732834
83Scanning speech (HP:0002168)2.11422770
84Anophthalmia (HP:0000528)2.10765470
85Hypsarrhythmia (HP:0002521)2.08516428
86Ankle clonus (HP:0011448)2.08388109
87Poor coordination (HP:0002370)2.07620919
88Dysmetria (HP:0001310)2.06442690
89Impaired social interactions (HP:0000735)2.05749881
90Abnormal social behavior (HP:0012433)2.05749881
91Fetal akinesia sequence (HP:0001989)2.05607238
92Chronic hepatic failure (HP:0100626)2.05431203
93Narrow nasal bridge (HP:0000446)2.05107383
94Degeneration of the lateral corticospinal tracts (HP:0002314)2.04623282
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.04623282
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04404511
97Inability to walk (HP:0002540)2.03625544
98Absent septum pellucidum (HP:0001331)2.01106308
99Birth length less than 3rd percentile (HP:0003561)2.00821020
100Urinary bladder sphincter dysfunction (HP:0002839)2.00757036
101Amyotrophic lateral sclerosis (HP:0007354)1.98554767
102Narrow forehead (HP:0000341)1.98343723
103Rib fusion (HP:0000902)1.97991809
104Stereotypic behavior (HP:0000733)1.96861705
105Neurofibrillary tangles (HP:0002185)1.96225295
106Blue irides (HP:0000635)1.95489358
107Generalized hypotonia (HP:0001290)1.94494388
108Abnormality of the labia minora (HP:0012880)1.92287215
109Micropenis (HP:0000054)1.91932804
110Sclerocornea (HP:0000647)1.91597361
111Abnormal respiratory epithelium morphology (HP:0012253)1.91395446
112Abnormal respiratory motile cilium morphology (HP:0005938)1.91395446
113Anencephaly (HP:0002323)1.91022870
114Abnormality of abdominal situs (HP:0011620)1.90014711
115Abdominal situs inversus (HP:0003363)1.90014711
116Hypoplastic left heart (HP:0004383)1.89709608
117Aplasia/Hypoplasia of the lens (HP:0008063)1.89517150
118Broad foot (HP:0001769)1.89434343
119Rhabdomyosarcoma (HP:0002859)1.89349844
120Postaxial hand polydactyly (HP:0001162)1.88831989
121Shoulder girdle muscle weakness (HP:0003547)1.88619699
122Type II lissencephaly (HP:0007260)1.87409638
123Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87141057
124Urinary urgency (HP:0000012)1.86996629
125Supernumerary spleens (HP:0009799)1.86919472
126Spastic gait (HP:0002064)1.86837636
127Intestinal atresia (HP:0011100)1.86682461
128Akinesia (HP:0002304)1.86017175
129Medulloblastoma (HP:0002885)1.85152856
130Rhinitis (HP:0012384)1.84460532
131Abnormality of the lower motor neuron (HP:0002366)1.83830664
132Cerebral inclusion bodies (HP:0100314)1.82428206
133Abnormality of salivation (HP:0100755)1.82327093
134Increased hepatocellular lipid droplets (HP:0006565)1.81692646
135Preaxial hand polydactyly (HP:0001177)1.81315311
136Megalencephaly (HP:0001355)1.81263207
137Occipital encephalocele (HP:0002085)1.81014064
138Oligodactyly (hands) (HP:0001180)1.80450066
139Decreased testicular size (HP:0008734)1.79679415
140Scrotal hypoplasia (HP:0000046)1.79591128
141Abnormality of the renal medulla (HP:0100957)1.78100316
142Atrophy/Degeneration involving motor neurons (HP:0007373)1.77172929
143Exotropia (HP:0000577)1.76599079
144Ependymoma (HP:0002888)1.74756901
145Genetic anticipation (HP:0003743)1.73645665
146Optic disc pallor (HP:0000543)1.72659059
147Lower limb muscle weakness (HP:0007340)1.72502827
148Bifid tongue (HP:0010297)1.70484848
149Large earlobe (HP:0009748)1.70424199
150Acute encephalopathy (HP:0006846)1.70121341
151Abnormality of the septum pellucidum (HP:0007375)1.69074864
152Optic nerve coloboma (HP:0000588)1.68933841
153Stenosis of the external auditory canal (HP:0000402)1.66924540
154Abnormal sex determination (HP:0012244)1.66786275
155Sex reversal (HP:0012245)1.66786275
156Renal hypoplasia (HP:0000089)1.66517739
157Labial hypoplasia (HP:0000066)1.65838119
158Aplasia/Hypoplasia of the uvula (HP:0010293)1.65549771
159Postaxial foot polydactyly (HP:0001830)1.65308267
160Dandy-Walker malformation (HP:0001305)1.64831535
161Chorioretinal coloboma (HP:0000567)1.62315989
162Split foot (HP:0001839)1.61399749
163Gastrointestinal atresia (HP:0002589)1.59040764
164Abnormal number of incisors (HP:0011064)1.58978524
165Absent eyebrow (HP:0002223)1.58677413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.86333733
2NTRK33.67584082
3MARK13.62714679
4EPHA43.06124310
5MAP3K42.73380143
6MAP2K72.70177767
7MAP3K92.66265012
8MAP3K122.63701354
9TRIM282.49452593
10MINK12.32791645
11NTRK22.17908980
12MAPK132.09811175
13SRPK12.08602830
14MKNK12.01997222
15MKNK21.95829307
16PLK21.92209854
17AKT31.90159197
18PLK41.85602608
19DYRK31.84002378
20PNCK1.76271108
21MAP2K41.71899415
22PINK11.65263422
23DAPK21.63288962
24SIK31.62557219
25PRPF4B1.57200940
26KSR11.56287985
27CDK191.56095551
28MAP4K21.53170450
29BUB11.50480575
30NUAK11.50044828
31TTK1.48944737
32CDC71.48041627
33BCR1.45085215
34UHMK11.39640740
35ZAK1.39439460
36ARAF1.34453993
37OXSR11.32482508
38NEK11.32403954
39TNIK1.32342948
40WEE11.29995985
41SGK2231.29522360
42SGK4941.29522360
43CDK51.27997164
44PRKCG1.27311782
45PLK11.23588184
46PAK61.23105126
47GRK51.22547192
48SGK21.21107019
49WNK31.17682532
50DAPK11.14380827
51RPS6KA41.11010236
52PHKG11.10190329
53PHKG21.10190329
54NTRK11.09946116
55CAMK2A1.09413059
56RIPK41.04567434
57DYRK21.04099327
58GRK71.03002549
59CSNK1G21.01451140
60VRK10.99406811
61KSR20.97324441
62CAMK2B0.97059738
63BRAF0.96064652
64LATS10.94324913
65STK38L0.93094098
66CCNB10.92476952
67NME10.92324225
68BMPR20.91752056
69CDK180.89436721
70DYRK1B0.87666231
71SIK20.87060376
72DYRK1A0.86481040
73BCKDK0.85652988
74STK390.85602783
75CDK140.83354133
76YES10.80231388
77PRKCE0.79951421
78STK160.79908949
79CDK150.78816852
80BRD40.78683814
81BRSK20.77749399
82CSNK1G30.77707602
83NEK20.77533162
84ATR0.73666416
85PBK0.73206294
86FGR0.72810224
87CDK11A0.68145838
88ADRBK10.67222710
89PAK30.66178531
90INSRR0.64993773
91WNK40.64895484
92PTK2B0.64723923
93TSSK60.64589734
94TYRO30.63948021
95ADRBK20.63945852
96ACVR1B0.63249507
97SGK30.61839940
98FES0.60729435
99VRK20.57959840
100CAMKK10.57142651
101FER0.55732828
102SGK10.55322151
103BMPR1B0.54145728
104CSNK1E0.53620813
105LIMK10.53176952
106CHEK20.52908780
107PASK0.52620456
108ERBB30.52524889
109RPS6KA20.52040168
110BRSK10.51407122
111CAMK2D0.51212713
112ROCK20.50834421
113PKN10.49444251
114MUSK0.49209832
115ATM0.49197565
116AURKB0.48673800
117GRK10.48390311
118STK110.48294740
119CAMK2G0.46602435
120CSNK1G10.46126560
121TGFBR10.45915095
122CSNK1A1L0.45143510
123PRKCZ0.43771567
124CDK30.42627764
125MAP2K10.39430265
126PRKACA0.39234069
127CAMKK20.39025963
128EPHB20.38905275
129EIF2AK30.38225330
130PRKDC0.38192639
131ERBB40.38046231
132MAP3K20.38024575
133AURKA0.37730734
134CDK10.37031455
135TNK20.36859805
136NEK60.35801257
137MAPK150.35726367
138CSNK1A10.35201686
139PRKD30.35157692
140MAPK120.33983943
141MAPK100.33559817
142MARK20.33519470
143RPS6KA30.32290345
144PLK30.30719934
145CAMK10.30613960

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.40467020
2Synaptic vesicle cycle_Homo sapiens_hsa047213.37721533
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85938419
4GABAergic synapse_Homo sapiens_hsa047272.83246056
5Protein export_Homo sapiens_hsa030602.65131008
6Morphine addiction_Homo sapiens_hsa050322.52943574
7Amphetamine addiction_Homo sapiens_hsa050312.47594102
8Circadian entrainment_Homo sapiens_hsa047132.47241270
9Glutamatergic synapse_Homo sapiens_hsa047242.44752038
10Collecting duct acid secretion_Homo sapiens_hsa049662.44531211
11Long-term potentiation_Homo sapiens_hsa047202.44367317
12Olfactory transduction_Homo sapiens_hsa047402.36667484
13Mismatch repair_Homo sapiens_hsa034302.27825732
14Steroid biosynthesis_Homo sapiens_hsa001002.26293618
15Dopaminergic synapse_Homo sapiens_hsa047282.23764117
16Oxidative phosphorylation_Homo sapiens_hsa001902.08471577
17Non-homologous end-joining_Homo sapiens_hsa034502.07803672
18Serotonergic synapse_Homo sapiens_hsa047262.07640241
19Taste transduction_Homo sapiens_hsa047422.05996823
20Cocaine addiction_Homo sapiens_hsa050301.92377181
21Insulin secretion_Homo sapiens_hsa049111.90835385
22Salivary secretion_Homo sapiens_hsa049701.87930977
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84049836
24Propanoate metabolism_Homo sapiens_hsa006401.82095389
25Fanconi anemia pathway_Homo sapiens_hsa034601.81935305
26Renin secretion_Homo sapiens_hsa049241.80056557
27RNA polymerase_Homo sapiens_hsa030201.77889994
28Long-term depression_Homo sapiens_hsa047301.75735791
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71170101
30Spliceosome_Homo sapiens_hsa030401.70318549
31Vibrio cholerae infection_Homo sapiens_hsa051101.64687571
32Cholinergic synapse_Homo sapiens_hsa047251.64264533
33Parkinsons disease_Homo sapiens_hsa050121.61875685
34Basal transcription factors_Homo sapiens_hsa030221.58509167
35Axon guidance_Homo sapiens_hsa043601.57946520
36Alzheimers disease_Homo sapiens_hsa050101.55046983
37Homologous recombination_Homo sapiens_hsa034401.54632579
38Gastric acid secretion_Homo sapiens_hsa049711.54458082
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52428628
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48126517
41Cardiac muscle contraction_Homo sapiens_hsa042601.46955833
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46104623
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.44541411
44Calcium signaling pathway_Homo sapiens_hsa040201.43503145
45Oxytocin signaling pathway_Homo sapiens_hsa049211.42584374
46Gap junction_Homo sapiens_hsa045401.41339706
47Base excision repair_Homo sapiens_hsa034101.39575798
48RNA degradation_Homo sapiens_hsa030181.38541321
49Proteasome_Homo sapiens_hsa030501.37557606
50DNA replication_Homo sapiens_hsa030301.37236641
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37209079
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36357807
53RNA transport_Homo sapiens_hsa030131.35835729
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32647331
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31120627
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.27970640
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26528181
58Phototransduction_Homo sapiens_hsa047441.22127256
59Huntingtons disease_Homo sapiens_hsa050161.18266342
60Cell cycle_Homo sapiens_hsa041101.18005940
61Fatty acid elongation_Homo sapiens_hsa000621.16030356
62Ribosome_Homo sapiens_hsa030101.15100148
63GnRH signaling pathway_Homo sapiens_hsa049121.13858382
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13685805
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13645619
66Pyruvate metabolism_Homo sapiens_hsa006201.11863363
67Melanogenesis_Homo sapiens_hsa049161.09429904
68mRNA surveillance pathway_Homo sapiens_hsa030151.07744922
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07636678
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06541941
71cAMP signaling pathway_Homo sapiens_hsa040241.03015196
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98569221
73Nucleotide excision repair_Homo sapiens_hsa034200.98511261
74ErbB signaling pathway_Homo sapiens_hsa040120.96909033
75Vitamin B6 metabolism_Homo sapiens_hsa007500.95795967
76Sulfur relay system_Homo sapiens_hsa041220.92605200
77Hippo signaling pathway_Homo sapiens_hsa043900.91945429
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91937668
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91613738
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89026537
81Estrogen signaling pathway_Homo sapiens_hsa049150.89020811
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83564986
83Selenocompound metabolism_Homo sapiens_hsa004500.83367530
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82919279
85Oocyte meiosis_Homo sapiens_hsa041140.82817495
86Purine metabolism_Homo sapiens_hsa002300.75574515
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75148280
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73858888
89Pyrimidine metabolism_Homo sapiens_hsa002400.73675201
90Glioma_Homo sapiens_hsa052140.73065644
91beta-Alanine metabolism_Homo sapiens_hsa004100.71325795
92Wnt signaling pathway_Homo sapiens_hsa043100.70660720
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.70361556
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70309994
95Peroxisome_Homo sapiens_hsa041460.69974922
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69967059
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69555337
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69516648
99Alcoholism_Homo sapiens_hsa050340.69198978
100Ether lipid metabolism_Homo sapiens_hsa005650.66049927
101MAPK signaling pathway_Homo sapiens_hsa040100.65739575
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64444333
103Type II diabetes mellitus_Homo sapiens_hsa049300.62896425
104Type I diabetes mellitus_Homo sapiens_hsa049400.62765769
105Hedgehog signaling pathway_Homo sapiens_hsa043400.62518165
106Linoleic acid metabolism_Homo sapiens_hsa005910.61546482
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59791866
108Arginine and proline metabolism_Homo sapiens_hsa003300.59711843
109Pancreatic secretion_Homo sapiens_hsa049720.59690359
110Dilated cardiomyopathy_Homo sapiens_hsa054140.59303667
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58836737
112Metabolic pathways_Homo sapiens_hsa011000.58802882
113Thyroid hormone synthesis_Homo sapiens_hsa049180.58490950
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56359200
115Folate biosynthesis_Homo sapiens_hsa007900.54567721
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53508154
117Ras signaling pathway_Homo sapiens_hsa040140.52713686
118Rheumatoid arthritis_Homo sapiens_hsa053230.49707322
119One carbon pool by folate_Homo sapiens_hsa006700.49397413
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49069849
121Butanoate metabolism_Homo sapiens_hsa006500.48749483
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47248113
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46545576
124Biosynthesis of amino acids_Homo sapiens_hsa012300.46441260
125TGF-beta signaling pathway_Homo sapiens_hsa043500.45494471
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45375340
127Tryptophan metabolism_Homo sapiens_hsa003800.45229604
128Phagosome_Homo sapiens_hsa041450.44070721
129Glucagon signaling pathway_Homo sapiens_hsa049220.43498568
130Dorso-ventral axis formation_Homo sapiens_hsa043200.43394910
131Choline metabolism in cancer_Homo sapiens_hsa052310.41627473
132Carbon metabolism_Homo sapiens_hsa012000.40326355
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39842051
134Prion diseases_Homo sapiens_hsa050200.38953748
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38323639
136Fatty acid metabolism_Homo sapiens_hsa012120.38308757
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.36824766
138Renal cell carcinoma_Homo sapiens_hsa052110.36588306
139Nitrogen metabolism_Homo sapiens_hsa009100.36237608
140Rap1 signaling pathway_Homo sapiens_hsa040150.35405833
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35310376
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34416719
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33909274
144Neurotrophin signaling pathway_Homo sapiens_hsa047220.33293255
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31648139
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.31471623
147Ovarian steroidogenesis_Homo sapiens_hsa049130.31314825
148Regulation of autophagy_Homo sapiens_hsa041400.31158071
149SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31020795
150Melanoma_Homo sapiens_hsa052180.27248126
151Circadian rhythm_Homo sapiens_hsa047100.26984898
152Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24693002
153Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22797042
154Inositol phosphate metabolism_Homo sapiens_hsa005620.22674112
155Tight junction_Homo sapiens_hsa045300.22241211
156Basal cell carcinoma_Homo sapiens_hsa052170.21192042

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