NUDT12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.27249365
2L-phenylalanine catabolic process (GO:0006559)7.27249365
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.96630212
4L-phenylalanine metabolic process (GO:0006558)6.96630212
5aromatic amino acid family catabolic process (GO:0009074)6.60374339
6tryptophan catabolic process (GO:0006569)6.02153862
7indole-containing compound catabolic process (GO:0042436)6.02153862
8indolalkylamine catabolic process (GO:0046218)6.02153862
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.99425592
10kynurenine metabolic process (GO:0070189)5.85904930
11bile acid biosynthetic process (GO:0006699)5.72541314
12glyoxylate metabolic process (GO:0046487)5.69784332
13tryptophan metabolic process (GO:0006568)5.66668023
14alpha-linolenic acid metabolic process (GO:0036109)5.60522565
15urea metabolic process (GO:0019627)5.43055946
16urea cycle (GO:0000050)5.43055946
17cysteine metabolic process (GO:0006534)5.38482974
18sulfur amino acid catabolic process (GO:0000098)5.19890000
19high-density lipoprotein particle remodeling (GO:0034375)5.13683590
20serine family amino acid catabolic process (GO:0009071)5.10527006
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.07799221
22negative regulation of fibrinolysis (GO:0051918)5.07158640
23nitrogen cycle metabolic process (GO:0071941)5.01882020
24lysine metabolic process (GO:0006553)4.99781548
25lysine catabolic process (GO:0006554)4.99781548
26complement activation, alternative pathway (GO:0006957)4.98016659
27peptidyl-glutamic acid carboxylation (GO:0017187)4.95527500
28protein carboxylation (GO:0018214)4.95527500
29regulation of fibrinolysis (GO:0051917)4.94995278
30regulation of protein activation cascade (GO:2000257)4.92764096
31bile acid metabolic process (GO:0008206)4.90891454
32homocysteine metabolic process (GO:0050667)4.89082991
33amino-acid betaine metabolic process (GO:0006577)4.87216626
34aromatic amino acid family metabolic process (GO:0009072)4.85058697
35regulation of triglyceride catabolic process (GO:0010896)4.82265666
36tyrosine metabolic process (GO:0006570)4.66797339
37alpha-amino acid catabolic process (GO:1901606)4.65042699
38regulation of complement activation (GO:0030449)4.60579704
39regulation of cholesterol esterification (GO:0010872)4.52372768
40acylglycerol homeostasis (GO:0055090)4.49670250
41triglyceride homeostasis (GO:0070328)4.49670250
42reverse cholesterol transport (GO:0043691)4.48522986
43macromolecular complex remodeling (GO:0034367)4.46106501
44plasma lipoprotein particle remodeling (GO:0034369)4.46106501
45protein-lipid complex remodeling (GO:0034368)4.46106501
46cellular ketone body metabolic process (GO:0046950)4.42108165
47cellular amino acid catabolic process (GO:0009063)4.32040538
48amine catabolic process (GO:0009310)4.29751481
49cellular biogenic amine catabolic process (GO:0042402)4.29751481
50indolalkylamine metabolic process (GO:0006586)4.29176432
51phospholipid efflux (GO:0033700)4.27497581
52glycine metabolic process (GO:0006544)4.25228419
53negative regulation of sterol transport (GO:0032372)4.24177594
54negative regulation of cholesterol transport (GO:0032375)4.24177594
55bile acid and bile salt transport (GO:0015721)4.22691590
56plasma lipoprotein particle clearance (GO:0034381)4.19775281
57cellular glucuronidation (GO:0052695)4.18660794
58serine family amino acid metabolic process (GO:0009069)4.17415505
59ethanol oxidation (GO:0006069)4.14950217
60glutamate metabolic process (GO:0006536)4.12384477
61imidazole-containing compound metabolic process (GO:0052803)4.07783593
62short-chain fatty acid metabolic process (GO:0046459)4.05644383
63benzene-containing compound metabolic process (GO:0042537)4.04870564
64drug catabolic process (GO:0042737)4.04015680
65cellular modified amino acid catabolic process (GO:0042219)4.00186884
66acetyl-CoA metabolic process (GO:0006084)3.99516868
67* coenzyme catabolic process (GO:0009109)3.99001126
68cholesterol efflux (GO:0033344)3.91934460
69organic acid catabolic process (GO:0016054)3.90029138
70carboxylic acid catabolic process (GO:0046395)3.90029138
71serine family amino acid biosynthetic process (GO:0009070)3.89517587
72dicarboxylic acid biosynthetic process (GO:0043650)3.88777883
73arginine metabolic process (GO:0006525)3.88036921
74fatty acid beta-oxidation (GO:0006635)3.86498523
75ketone body metabolic process (GO:1902224)3.84082814
76fatty acid oxidation (GO:0019395)3.80579036
772-oxoglutarate metabolic process (GO:0006103)3.78934410
78aldehyde catabolic process (GO:0046185)3.78145192
79positive regulation of lipid catabolic process (GO:0050996)3.77292356
80carnitine metabolic process (GO:0009437)3.76755449
81lipid oxidation (GO:0034440)3.73820968
82glucuronate metabolic process (GO:0019585)3.73629802
83uronic acid metabolic process (GO:0006063)3.73629802
84low-density lipoprotein particle remodeling (GO:0034374)3.73168280
85monocarboxylic acid catabolic process (GO:0072329)3.73038625
86plasma lipoprotein particle assembly (GO:0034377)3.72018212
87negative regulation of lipase activity (GO:0060192)3.70236819
88fatty acid catabolic process (GO:0009062)3.70028485
89aspartate family amino acid catabolic process (GO:0009068)3.69435565
90phospholipid homeostasis (GO:0055091)3.68691105
91drug transmembrane transport (GO:0006855)3.65496730
92fibrinolysis (GO:0042730)3.64412334
93regulation of bile acid biosynthetic process (GO:0070857)3.64372676
94urate metabolic process (GO:0046415)3.64322518
95positive regulation of fatty acid beta-oxidation (GO:0032000)3.63512161
96cholesterol homeostasis (GO:0042632)3.61496721
97very-low-density lipoprotein particle assembly (GO:0034379)3.59960802
98sterol homeostasis (GO:0055092)3.56878250
99exogenous drug catabolic process (GO:0042738)3.56532146
100positive regulation of lipoprotein lipase activity (GO:0051006)3.54394534
101branched-chain amino acid catabolic process (GO:0009083)3.38419549
102water-soluble vitamin biosynthetic process (GO:0042364)2.99637332
103L-serine metabolic process (GO:0006563)2.89150625
104regulation of glucokinase activity (GO:0033131)2.77783414
105regulation of hexokinase activity (GO:1903299)2.77783414
106regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.71078933
107response to nitrosative stress (GO:0051409)2.64380203
108cholesterol biosynthetic process (GO:0006695)2.61101234
109tricarboxylic acid cycle (GO:0006099)2.60584210
110branched-chain amino acid metabolic process (GO:0009081)2.59651663
111sterol biosynthetic process (GO:0016126)2.50891886
112intraciliary transport (GO:0042073)2.50003369
113positive regulation of glycolytic process (GO:0045821)2.48842521
114fatty acid homeostasis (GO:0055089)2.46315275
115phenylpropanoid metabolic process (GO:0009698)2.35997510
116paraxial mesoderm development (GO:0048339)2.35622195
117lactate metabolic process (GO:0006089)2.34964428
118polyketide metabolic process (GO:0030638)2.34669500
119doxorubicin metabolic process (GO:0044598)2.34669500
120daunorubicin metabolic process (GO:0044597)2.34669500
121cellular aldehyde metabolic process (GO:0006081)2.31707345
122COPII vesicle coating (GO:0048208)2.31048622
123pteridine-containing compound biosynthetic process (GO:0042559)2.31003119
124regulation of sulfur metabolic process (GO:0042762)2.30287720
125retinal metabolic process (GO:0042574)2.30071144
126epoxygenase P450 pathway (GO:0019373)2.27360959
127regulation of acyl-CoA biosynthetic process (GO:0050812)2.27324225
128protein prenylation (GO:0018342)2.26715500
129prenylation (GO:0097354)2.26715500
130aminoglycoside antibiotic metabolic process (GO:0030647)2.25088749
131peptidyl-cysteine modification (GO:0018198)2.24419126
132carnitine transport (GO:0015879)2.24189775
133amino-acid betaine transport (GO:0015838)2.24189775
134regulation of coenzyme metabolic process (GO:0051196)2.21221198
135regulation of cofactor metabolic process (GO:0051193)2.21221198
136carnitine shuttle (GO:0006853)2.18503236
137regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.17041304
138terpenoid biosynthetic process (GO:0016114)2.16702146
139isoprenoid biosynthetic process (GO:0008299)2.16177305
140glutamine metabolic process (GO:0006541)2.13709005
141DNA ligation (GO:0006266)2.11644385
142establishment of integrated proviral latency (GO:0075713)2.11471476
143mitotic metaphase plate congression (GO:0007080)2.11409249
144metaphase plate congression (GO:0051310)2.11361443
145L-alpha-amino acid transmembrane transport (GO:1902475)2.09776274
146DNA double-strand break processing (GO:0000729)2.06504929
147epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.06141111
148epithelial cilium movement (GO:0003351)2.05887578
149righting reflex (GO:0060013)2.05068573
150S-adenosylmethionine metabolic process (GO:0046500)2.03085619
151oxidative phosphorylation (GO:0006119)1.98578587
152presynaptic membrane assembly (GO:0097105)1.98462113
153omega-hydroxylase P450 pathway (GO:0097267)1.98017297
154sulfur amino acid biosynthetic process (GO:0000097)1.97661410
155regulation of type B pancreatic cell apoptotic process (GO:2000674)1.95935472
156hair cell differentiation (GO:0035315)1.95557226
157regulation of mitochondrial translation (GO:0070129)1.95252340
158zinc ion transport (GO:0006829)1.94377346
159primary alcohol catabolic process (GO:0034310)1.92110954
160amino acid salvage (GO:0043102)1.92064247
161L-methionine salvage (GO:0071267)1.92064247
162L-methionine biosynthetic process (GO:0071265)1.92064247
163vitamin biosynthetic process (GO:0009110)1.91667148
164protein localization to kinetochore (GO:0034501)1.91606264
165tRNA aminoacylation for protein translation (GO:0006418)1.91576325
166resolution of meiotic recombination intermediates (GO:0000712)1.90965739
167quinone metabolic process (GO:1901661)1.90364882
168response to redox state (GO:0051775)1.90097329
169regulation of protein glycosylation (GO:0060049)1.89145586
170aspartate family amino acid metabolic process (GO:0009066)1.89004593
171presynaptic membrane organization (GO:0097090)1.88803076
172biotin metabolic process (GO:0006768)1.88497453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.14590688
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.99245428
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.75535703
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.34614424
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.74897106
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.20652208
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.89847371
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.02130411
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.88240680
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80376315
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.72831022
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55171404
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45122125
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.40257642
15FUS_26573619_Chip-Seq_HEK293_Human2.21117704
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.08478464
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06469499
18IGF1R_20145208_ChIP-Seq_DFB_Human2.02684137
19* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4612425
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93498793
21AR_21909140_ChIP-Seq_LNCAP_Human1.92264114
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.90768090
23* ELK1_19687146_ChIP-ChIP_HELA_Human1.85579724
24* EWS_26573619_Chip-Seq_HEK293_Human1.82403271
25RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.81685649
26* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80602408
27GBX2_23144817_ChIP-Seq_PC3_Human1.79793252
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.75200217
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70854675
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64753963
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62881710
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61727426
33CLOCK_20551151_ChIP-Seq_293T_Human1.60971905
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.60797384
35* P300_19829295_ChIP-Seq_ESCs_Human1.60366660
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.59588940
37GATA1_22025678_ChIP-Seq_K562_Human1.56907249
38HTT_18923047_ChIP-ChIP_STHdh_Human1.56467897
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.54022125
40* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52773975
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49113052
42HNF4A_19822575_ChIP-Seq_HepG2_Human1.44021278
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39090957
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35787908
45* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35417601
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35276966
47SMAD4_21799915_ChIP-Seq_A2780_Human1.32319125
48* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30092280
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28235290
50CBP_20019798_ChIP-Seq_JUKART_Human1.24489512
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24489512
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22136223
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21852461
54* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20545598
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20245454
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.18788545
57VDR_22108803_ChIP-Seq_LS180_Human1.18054699
58ZNF274_21170338_ChIP-Seq_K562_Hela1.17404428
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16950488
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16856340
61* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16719535
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16486894
63MYC_18555785_ChIP-Seq_MESCs_Mouse1.16033883
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14655996
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14607040
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14468866
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14356881
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.12862502
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10614573
70RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09641973
71MYC_18940864_ChIP-ChIP_HL60_Human1.09289036
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08509025
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08210553
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.07508164
75P53_22387025_ChIP-Seq_ESCs_Mouse1.07473283
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.06373631
77WT1_19549856_ChIP-ChIP_CCG9911_Human1.05770265
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05762403
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05144622
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05047030
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04127766
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04085605
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03976208
84ER_23166858_ChIP-Seq_MCF-7_Human1.02509575
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02251758
86* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01764214
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01379282
88PHF8_20622853_ChIP-Seq_HELA_Human1.00172714
89TCF4_22108803_ChIP-Seq_LS180_Human0.99497663
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99272704
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98643727
92MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96163975
93TBL1_22424771_ChIP-Seq_293T_Human0.96163900
94E2F1_18555785_Chip-Seq_ESCs_Mouse0.95960694
95NFYB_21822215_ChIP-Seq_K562_Human0.95718124
96* STAT3_23295773_ChIP-Seq_U87_Human0.94973539
97CMYC_18555785_Chip-Seq_ESCs_Mouse0.94951371
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.94764145
99CBX2_27304074_Chip-Seq_ESCs_Mouse0.94678579
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94357473
101ETS1_20019798_ChIP-Seq_JURKAT_Human0.92752273
102RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92667767
103SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92589992
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92507985
105SOX2_18555785_Chip-Seq_ESCs_Mouse0.91512470
106ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91142524
107SOX2_16153702_ChIP-ChIP_HESCs_Human0.91053694
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90969928
109NFE2_27457419_Chip-Seq_LIVER_Mouse0.90768076
110NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90127780
111AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90099782
112P300_18555785_Chip-Seq_ESCs_Mouse0.90067916
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90067820
114SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89725484
115* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89617554
116* SOX9_26525672_Chip-Seq_HEART_Mouse0.89050170
117* GATA4_25053715_ChIP-Seq_YYC3_Human0.88643331
118KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84254042
119SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77882690
120ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77470310
121AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77032858
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76957089
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76957089
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76930197
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76924062
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76508757
127ESR2_21235772_ChIP-Seq_MCF-7_Human0.73574384
128E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.72630883
129TAF15_26573619_Chip-Seq_HEK293_Human0.72453693
130CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71288027
131GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.70975417
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69173109
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.67533207
134ESR1_21235772_ChIP-Seq_MCF-7_Human0.65575180
135ZNF263_19887448_ChIP-Seq_K562_Human0.65391756
136BCAT_22108803_ChIP-Seq_LS180_Human0.64496049
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.63315042
138PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.63200996
139RARA_24833708_ChIP-Seq_LIVER_Mouse0.62945644
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61433610
141IRF8_22096565_ChIP-ChIP_GC-B_Human0.60840152
142CEBPB_22108803_ChIP-Seq_LS180_Human0.59741711
143BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59597011
144AR_20517297_ChIP-Seq_VCAP_Human0.58833916
145PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.58320104
146FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58299736
147FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.57488600
148ESR1_20079471_ChIP-ChIP_T-47D_Human0.56453926
149CBP_21632823_ChIP-Seq_H3396_Human0.55504709
150* STAT1_17558387_ChIP-Seq_HELA_Human0.52750852
151FOXA1_25552417_ChIP-Seq_VCAP_Human0.52555446
152ESET_19884257_ChIP-Seq_ESCs_Mouse0.52366500
153STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52180287
154PIAS1_25552417_ChIP-Seq_VCAP_Human0.52161966
155* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.51975674
156CDX2_20551321_ChIP-Seq_CACO-2_Human0.50518035
157FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50475088
158RARB_24833708_ChIP-Seq_LIVER_Mouse0.50307987
159EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.49563351
160RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.49532510
161PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.47923947
162CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.47682938
163* CDX2_22108803_ChIP-Seq_LS180_Human0.47408036
164PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45987744
165SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.45158308
166MYC_19915707_ChIP-ChIP_AK7_Human0.44320650
167FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43849289
168FOXO3_23340844_ChIP-Seq_DLD1_Human0.43730662
169FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.43245140
170TAF2_19829295_ChIP-Seq_ESCs_Human0.43137619
171NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.42255414
172SOX2_20726797_ChIP-Seq_SW620_Human0.41999061
173P53_21459846_ChIP-Seq_SAOS-2_Human0.41918297
174PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.41806134
175ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.41715475
176* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.41349477
177ERG_20517297_ChIP-Seq_VCAP_Human0.41187302
178EGR1_19032775_ChIP-ChIP_M12_Human0.40514387
179FOXH1_21741376_ChIP-Seq_EPCs_Human0.40157108
180CRX_20693478_ChIP-Seq_RETINA_Mouse0.38840581
181GATA2_19941826_ChIP-Seq_K562_Human0.38103359
182NCOR_22424771_ChIP-Seq_293T_Human0.37571883
183OCT4_21477851_ChIP-Seq_ESCs_Mouse0.36905551
184GATA3_24758297_ChIP-Seq_MCF-7_Human0.36788949
185NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.36435387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.18605973
2MP0005360_urolithiasis7.44062734
3MP0005085_abnormal_gallbladder_physiolo6.29811646
4MP0005365_abnormal_bile_salt6.10263116
5MP0008875_abnormal_xenobiotic_pharmacok4.93945033
6MP0003806_abnormal_nucleotide_metabolis4.09293880
7MP0003252_abnormal_bile_duct3.98743620
8MP0010234_abnormal_vibrissa_follicle3.64598654
9MP0010329_abnormal_lipoprotein_level3.57508842
10MP0005332_abnormal_amino_acid3.00255053
11MP0009840_abnormal_foam_cell2.98437718
12MP0005083_abnormal_biliary_tract2.92484925
13MP0003195_calcinosis2.86219272
14MP0003136_yellow_coat_color2.68526645
15MP0001666_abnormal_nutrient_absorption2.57555289
16MP0003941_abnormal_skin_development2.33452582
17MP0004019_abnormal_vitamin_homeostasis2.32172532
18MP0002118_abnormal_lipid_homeostasis2.18172220
19MP0003191_abnormal_cellular_cholesterol2.15031183
20MP0002138_abnormal_hepatobiliary_system2.14017095
21MP0000609_abnormal_liver_physiology2.12696714
22MP0002938_white_spotting2.02958296
23MP0003868_abnormal_feces_composition1.95106914
24MP0006072_abnormal_retinal_apoptosis1.88745314
25MP0005319_abnormal_enzyme/_coenzyme1.84104669
26MP0009780_abnormal_chondrocyte_physiolo1.73669765
27MP0001764_abnormal_homeostasis1.72227593
28MP0010678_abnormal_skin_adnexa1.66156494
29MP0009697_abnormal_copulation1.66014252
30MP0001984_abnormal_olfaction1.63038053
31MP0005584_abnormal_enzyme/coenzyme_acti1.61148785
32MP0005670_abnormal_white_adipose1.60222646
33MP0001529_abnormal_vocalization1.51963557
34MP0000566_synostosis1.45221347
35MP0003283_abnormal_digestive_organ1.42776209
36MP0008058_abnormal_DNA_repair1.41065129
37MP0003186_abnormal_redox_activity1.40931275
38MP0009643_abnormal_urine_homeostasis1.40551239
39MP0002102_abnormal_ear_morphology1.40101207
40MP0005187_abnormal_penis_morphology1.37898917
41MP0005451_abnormal_body_composition1.35891644
42MP0003011_delayed_dark_adaptation1.35296162
43MP0002090_abnormal_vision1.33648416
44MP0003937_abnormal_limbs/digits/tail_de1.30747246
45MP0005253_abnormal_eye_physiology1.26350320
46MP0004215_abnormal_myocardial_fiber1.26224071
47MP0005647_abnormal_sex_gland1.18248016
48MP0001299_abnormal_eye_distance/1.16360780
49MP0003656_abnormal_erythrocyte_physiolo1.13422994
50MP0002234_abnormal_pharynx_morphology1.12707477
51MP0002233_abnormal_nose_morphology1.10066727
52MP0000598_abnormal_liver_morphology1.09919224
53MP0002909_abnormal_adrenal_gland1.09255810
54MP0004130_abnormal_muscle_cell1.08767893
55MP0003880_abnormal_central_pattern1.08531536
56MP0002876_abnormal_thyroid_physiology1.07818373
57MP0008057_abnormal_DNA_replication1.07689880
58MP0006036_abnormal_mitochondrial_physio1.07365028
59MP0008789_abnormal_olfactory_epithelium1.06102862
60MP0009764_decreased_sensitivity_to1.04330968
61MP0003693_abnormal_embryo_hatching1.04171853
62MP0000647_abnormal_sebaceous_gland1.04008535
63MP0001293_anophthalmia1.03959282
64MP0005636_abnormal_mineral_homeostasis1.02746902
65MP0000383_abnormal_hair_follicle1.02687474
66MP0005171_absent_coat_pigmentation1.02083949
67MP0002971_abnormal_brown_adipose0.98826196
68MP0010352_gastrointestinal_tract_polyps0.98483690
69MP0000013_abnormal_adipose_tissue0.96481175
70MP0004145_abnormal_muscle_electrophysio0.96066104
71MP0004133_heterotaxia0.95888858
72MP0004957_abnormal_blastocyst_morpholog0.94337433
73MP0009763_increased_sensitivity_to0.93202369
74MP0000462_abnormal_digestive_system0.92699399
75MP0008932_abnormal_embryonic_tissue0.91589158
76MP0004270_analgesia0.91093035
77MP0002697_abnormal_eye_size0.90586381
78MP0003705_abnormal_hypodermis_morpholog0.90523262
79MP0004885_abnormal_endolymph0.89728629
80MP0002254_reproductive_system_inflammat0.89012826
81MP0001661_extended_life_span0.88011889
82MP0002078_abnormal_glucose_homeostasis0.87705936
83MP0003122_maternal_imprinting0.87446800
84MP0005535_abnormal_body_temperature0.87239234
85MP0000604_amyloidosis0.86716720
86MP0001485_abnormal_pinna_reflex0.86354166
87MP0005666_abnormal_adipose_tissue0.86246933
88MP0009642_abnormal_blood_homeostasis0.85818401
89MP0005334_abnormal_fat_pad0.85034660
90MP0002084_abnormal_developmental_patter0.84418110
91MP0010368_abnormal_lymphatic_system0.84053966
92MP0003890_abnormal_embryonic-extraembry0.83904262
93MP0005379_endocrine/exocrine_gland_phen0.82753906
94MP0003119_abnormal_digestive_system0.82662066
95MP0006292_abnormal_olfactory_placode0.82460512
96MP0005220_abnormal_exocrine_pancreas0.82181680
97MP0010094_abnormal_chromosome_stability0.81931317
98MP0000427_abnormal_hair_cycle0.81698598
99MP0005391_vision/eye_phenotype0.81514754
100MP0005408_hypopigmentation0.81311630
101MP0003787_abnormal_imprinting0.80957050
102MP0008469_abnormal_protein_level0.80389114
103MP0001944_abnormal_pancreas_morphology0.78891090
104MP0005376_homeostasis/metabolism_phenot0.78518233
105MP0005084_abnormal_gallbladder_morpholo0.78170183
106MP0004272_abnormal_basement_membrane0.78109976
107MP0001756_abnormal_urination0.77846495
108MP0001188_hyperpigmentation0.76606622
109MP0000749_muscle_degeneration0.76603274
110MP0003755_abnormal_palate_morphology0.75538447
111MP0008877_abnormal_DNA_methylation0.74600343
112MP0002837_dystrophic_cardiac_calcinosis0.74384476
113MP0004085_abnormal_heartbeat0.74113787
114MP0000631_abnormal_neuroendocrine_gland0.73112147
115MP0005551_abnormal_eye_electrophysiolog0.73048500
116MP0001346_abnormal_lacrimal_gland0.72939918
117MP0009765_abnormal_xenobiotic_induced0.71736594
118MP0002638_abnormal_pupillary_reflex0.70471955
119MP0006035_abnormal_mitochondrial_morpho0.68658454
120MP0001286_abnormal_eye_development0.68531410
121MP0003137_abnormal_impulse_conducting0.68460643
122MP0005266_abnormal_metabolism0.68172466
123MP0002269_muscular_atrophy0.68156647
124MP0003690_abnormal_glial_cell0.68043356
125MP0000537_abnormal_urethra_morphology0.67169153
126MP0002177_abnormal_outer_ear0.66939356
127MP0000516_abnormal_urinary_system0.66676544
128MP0005448_abnormal_energy_balance0.61054607
129MP0003724_increased_susceptibility_to0.60881998
130MP0002136_abnormal_kidney_physiology0.57762138
131MP0005395_other_phenotype0.56090549
132MP0004043_abnormal_pH_regulation0.54650980
133MP0002822_catalepsy0.54395264
134MP0003718_maternal_effect0.53709259
135MP0002928_abnormal_bile_duct0.53565048
136MP0000639_abnormal_adrenal_gland0.53129990
137MP0003329_amyloid_beta_deposits0.51314833
138MP0009115_abnormal_fat_cell0.51169244
139MP0009053_abnormal_anal_canal0.49570212
140MP0003953_abnormal_hormone_level0.48335049
141MP0003638_abnormal_response/metabolism_0.47691340
142MP0004381_abnormal_hair_follicle0.46489701
143MP0002796_impaired_skin_barrier0.45482233
144MP0002970_abnormal_white_adipose0.45403760
145MP0000230_abnormal_systemic_arterial0.44701507
146MP0002168_other_aberrant_phenotype0.41778951
147MP0004782_abnormal_surfactant_physiolog0.41285080
148MP0005248_abnormal_Harderian_gland0.40152826
149MP0008874_decreased_physiological_sensi0.38877698
150MP0003959_abnormal_lean_body0.38640171
151MP0008872_abnormal_physiological_respon0.35327176
152MP0009384_cardiac_valve_regurgitation0.34528478
153MP0001881_abnormal_mammary_gland0.34095467
154MP0005375_adipose_tissue_phenotype0.33938046
155MP0009672_abnormal_birth_weight0.33387156
156MP0001765_abnormal_ion_homeostasis0.33013795
157MP0004185_abnormal_adipocyte_glucose0.32549289
158MP0008873_increased_physiological_sensi0.31985279
159MP0004147_increased_porphyrin_level0.31672869
160MP0005464_abnormal_platelet_physiology0.27844236
161MP0001853_heart_inflammation0.26665703
162MP0005452_abnormal_adipose_tissue0.25981476
163MP0005058_abnormal_lysosome_morphology0.24834267
164MP0002060_abnormal_skin_morphology0.24810331
165MP0005166_decreased_susceptibility_to0.24412850
166MP0000249_abnormal_blood_vessel0.24298989
167MP0000579_abnormal_nail_morphology0.23911968
168MP0002135_abnormal_kidney_morphology0.23355523

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.88765711
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.87041541
3Deep venous thrombosis (HP:0002625)6.71486524
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.20544637
5Xanthomatosis (HP:0000991)6.05277759
6Hypobetalipoproteinemia (HP:0003563)5.96442525
7Prolonged partial thromboplastin time (HP:0003645)5.95711444
8Hyperlipoproteinemia (HP:0010980)5.52744457
9Hyperglycinemia (HP:0002154)4.93024910
10Complement deficiency (HP:0004431)4.88426288
11Hyperammonemia (HP:0001987)4.86845718
12Hyperglycinuria (HP:0003108)4.65434794
13Hypolipoproteinemia (HP:0010981)4.59535254
14Abnormality of serine family amino acid metabolism (HP:0010894)4.54378871
15Abnormality of glycine metabolism (HP:0010895)4.54378871
16Ketosis (HP:0001946)4.53008816
17Epidermoid cyst (HP:0200040)4.43464004
18Joint hemorrhage (HP:0005261)4.33152060
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.32561857
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.32550322
21Hypoglycemic coma (HP:0001325)4.30140078
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.12396253
23Hypoalphalipoproteinemia (HP:0003233)4.10769451
24Abnormality of sulfur amino acid metabolism (HP:0004339)4.06548018
25Abnormality of the common coagulation pathway (HP:0010990)4.00765810
26Abnormality of methionine metabolism (HP:0010901)3.98241419
27Fat malabsorption (HP:0002630)3.95591495
28Abnormality of fatty-acid metabolism (HP:0004359)3.78727911
29Conjugated hyperbilirubinemia (HP:0002908)3.65789566
30Abnormality of pyrimidine metabolism (HP:0004353)3.63231035
31Ketoacidosis (HP:0001993)3.50441814
32Hypercholesterolemia (HP:0003124)3.49320623
33Abnormality of complement system (HP:0005339)3.49227589
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.45411244
35Abnormality of the intrinsic pathway (HP:0010989)3.45272493
36Abnormality of serum amino acid levels (HP:0003112)3.39737808
37Abnormality of nucleobase metabolism (HP:0010932)3.19955266
38Hyperbilirubinemia (HP:0002904)3.17104725
39Delayed CNS myelination (HP:0002188)3.15966591
40Dicarboxylic aciduria (HP:0003215)3.08382050
41Abnormality of dicarboxylic acid metabolism (HP:0010995)3.08382050
42Metabolic acidosis (HP:0001942)3.01491406
43Abnormality of purine metabolism (HP:0004352)2.98317382
44Steatorrhea (HP:0002570)2.97720330
45Lethargy (HP:0001254)2.92579965
46Gout (HP:0001997)2.87891983
47Hepatocellular carcinoma (HP:0001402)2.85089206
48Intestinal atresia (HP:0011100)2.75235606
49Myocardial infarction (HP:0001658)2.72463479
50Skin nodule (HP:0200036)2.71852845
51Cerebral edema (HP:0002181)2.67850349
52Generalized aminoaciduria (HP:0002909)2.64658402
53Exercise-induced muscle cramps (HP:0003710)2.64521818
54Vascular calcification (HP:0004934)2.61503961
55Hypoglycemic seizures (HP:0002173)2.59788789
56Spontaneous abortion (HP:0005268)2.55988443
57Hypochromic microcytic anemia (HP:0004840)2.54944228
58Double outlet right ventricle (HP:0001719)2.50211643
59Congenital malformation of the right heart (HP:0011723)2.50211643
60Calf muscle hypertrophy (HP:0008981)2.49487767
61Muscle hypertrophy of the lower extremities (HP:0008968)2.44579698
62Acanthocytosis (HP:0001927)2.43338260
63Pancreatic islet-cell hyperplasia (HP:0004510)2.41168817
64Proximal tubulopathy (HP:0000114)2.39184526
65Medial flaring of the eyebrow (HP:0010747)2.38854210
66Renal cortical cysts (HP:0000803)2.37253790
67Systemic lupus erythematosus (HP:0002725)2.36587502
68Irritability (HP:0000737)2.36191603
69Neonatal onset (HP:0003623)2.35147688
70Spastic diplegia (HP:0001264)2.34410814
71Enlarged kidneys (HP:0000105)2.34118535
72Abnormal gallbladder morphology (HP:0012437)2.32257698
73Vomiting (HP:0002013)2.31595079
74Cardiovascular calcification (HP:0011915)2.31298244
75Symptomatic seizures (HP:0011145)2.26961192
76Cholelithiasis (HP:0001081)2.25689561
77Malnutrition (HP:0004395)2.24118877
78Pancreatitis (HP:0001733)2.22955492
79Sensorimotor neuropathy (HP:0007141)2.22610960
80Abnormality of proline metabolism (HP:0010907)2.21545640
81Hydroxyprolinuria (HP:0003080)2.21545640
82Abnormal biliary tract morphology (HP:0012440)2.21379207
83Increased circulating renin level (HP:0000848)2.19430347
84Congenital primary aphakia (HP:0007707)2.16578771
85Brushfield spots (HP:0001088)2.15775120
86Abnormality of endocrine pancreas physiology (HP:0012093)2.15542333
87Abnormality of the pancreatic islet cells (HP:0006476)2.15542333
88Increased purine levels (HP:0004368)2.15326153
89Hyperuricemia (HP:0002149)2.15326153
90Papillary thyroid carcinoma (HP:0002895)2.14414585
91Mitral stenosis (HP:0001718)2.14112750
92Abnormal gallbladder physiology (HP:0012438)2.12941752
93Cholecystitis (HP:0001082)2.12941752
94Glycosuria (HP:0003076)2.12667394
95Abnormality of urine glucose concentration (HP:0011016)2.12667394
96Late onset (HP:0003584)2.10578900
97Hyperinsulinemic hypoglycemia (HP:0000825)2.09210045
98Nephrogenic diabetes insipidus (HP:0009806)2.05660661
99Glomerulonephritis (HP:0000099)2.05329700
100Esophageal varix (HP:0002040)2.04150385
101Alkalosis (HP:0001948)2.03693401
102Gait imbalance (HP:0002141)2.03310019
103Nausea (HP:0002018)2.01387099
104Rickets (HP:0002748)1.99695121
105Methylmalonic acidemia (HP:0002912)1.99004957
106Abnormality of vitamin B metabolism (HP:0004340)1.98585136
107Thyroid carcinoma (HP:0002890)1.97472706
108Colon cancer (HP:0003003)1.96281022
109Recurrent gram-negative bacterial infections (HP:0005420)1.94898959
110Menorrhagia (HP:0000132)1.94893397
111Gastrointestinal atresia (HP:0002589)1.94081364
112Hemorrhage of the eye (HP:0011885)1.93620804
113Pancreatic fibrosis (HP:0100732)1.93505280
114Increased serum pyruvate (HP:0003542)1.92683588
115Hyperphosphaturia (HP:0003109)1.92510354
116Genital tract atresia (HP:0001827)1.92247253
117Opisthotonus (HP:0002179)1.92178261
118Amyloidosis (HP:0011034)1.90919214
119Abnormality of vitamin metabolism (HP:0100508)1.87909073
120Lipid accumulation in hepatocytes (HP:0006561)1.87792430
121Vaginal atresia (HP:0000148)1.87628604
122Abnormal cartilage morphology (HP:0002763)1.87247185
123Hyperglycemia (HP:0003074)1.87035356
124Large for gestational age (HP:0001520)1.86775377
125Elevated hepatic transaminases (HP:0002910)1.85486046
126Hypomagnesemia (HP:0002917)1.85328226
127Abnormality of the gallbladder (HP:0005264)1.85215862
128Abnormality of glycolysis (HP:0004366)1.84939027
129Poikilocytosis (HP:0004447)1.84204791
130Neoplasm of the adrenal gland (HP:0100631)1.83875791
131Acute encephalopathy (HP:0006846)1.82880818
132Abnormal enzyme/coenzyme activity (HP:0012379)1.81571922
133Hypophosphatemic rickets (HP:0004912)1.81375763
134Increased hepatocellular lipid droplets (HP:0006565)1.79677504
135Hyperactive renin-angiotensin system (HP:0000841)1.73333660
136Megaloblastic anemia (HP:0001889)1.73289024
137Poor coordination (HP:0002370)1.72465297
138True hermaphroditism (HP:0010459)1.68387014
139Median cleft lip (HP:0000161)1.66524412
140Adrenal hypoplasia (HP:0000835)1.66438697
141Pheochromocytoma (HP:0002666)1.65858808
142Acute necrotizing encephalopathy (HP:0006965)1.64759352
143Biliary tract neoplasm (HP:0100574)1.63711031
144Abnormality of the calf musculature (HP:0001430)1.63315910
145Abnormality of the metopic suture (HP:0005556)1.63102274
146Progressive macrocephaly (HP:0004481)1.60841654
147Patchy hypopigmentation of hair (HP:0011365)1.60095331
148Increased CSF lactate (HP:0002490)1.59295330
149Abnormality of the renal cortex (HP:0011035)1.58959277
150Shoulder girdle muscle weakness (HP:0003547)1.58727944
151Abnormality of the vitamin B12 metabolism (HP:0004341)1.57314660
152Prominent metopic ridge (HP:0005487)1.54535745
153Pancreatic cysts (HP:0001737)1.53751801
154Hypothermia (HP:0002045)1.53738116
155Type II lissencephaly (HP:0007260)1.53208212
156Chorioretinal atrophy (HP:0000533)1.53052148
157Nephronophthisis (HP:0000090)1.52839182
158Abnormal biliary tract physiology (HP:0012439)1.52487074
159Bile duct proliferation (HP:0001408)1.52487074
160Esophageal atresia (HP:0002032)1.52442659
161Bifid tongue (HP:0010297)1.52389672
162Right ventricular cardiomyopathy (HP:0011663)1.52108477
163Rhinitis (HP:0012384)1.51911318
164Hepatoblastoma (HP:0002884)1.51783224
165Hemivertebrae (HP:0002937)1.51444894
166Insulin-resistant diabetes mellitus (HP:0000831)1.51076907
167Abnormality of the labia minora (HP:0012880)1.51001326

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.73708693
2SIK14.64698774
3FGFR43.95229163
4ERN13.71232969
5INSRR3.34629010
6TAOK32.63432457
7ERBB42.62149496
8MST1R2.58417432
9ERBB32.26240795
10MAP2K42.15490681
11MST42.08215030
12TTK2.06294254
13PBK2.05387859
14EIF2AK12.00128055
15CASK1.94992294
16FLT31.90527056
17STK391.79661807
18PASK1.78558787
19LATS11.78505978
20STK38L1.76153626
21PLK31.74661393
22MAPK111.74157406
23TSSK61.70996265
24TAF11.69923326
25FRK1.69657415
26PINK11.66703632
27PNCK1.64057703
28PIK3CG1.63127005
29MAP3K41.58900882
30BCR1.58473894
31TNIK1.52323391
32TRIB31.51584880
33BRSK21.49068619
34BUB11.48118075
35MAP4K21.47331879
36PRKAA21.46940156
37PLK21.44022194
38NEK91.43649977
39PKN21.42567026
40MKNK11.42424806
41EPHA41.38962139
42ABL21.37731484
43EIF2AK31.35603881
44PDK41.34710364
45PDK31.34710364
46MKNK21.29421810
47STK161.24738660
48VRK21.24213025
49SRPK11.24026573
50KDR1.23408387
51WEE11.23316118
52TRIM281.19098000
53CSNK1G31.19077176
54BMPR1B1.18347205
55PHKG21.17918028
56PHKG11.17918028
57VRK11.17392270
58TYK21.16624192
59CAMK1D1.15401679
60CSNK1G21.15197107
61PTK61.15152444
62DAPK21.14223645
63CDC71.10017850
64IRAK31.05732478
65FGFR21.03488891
66ACVR1B1.02091438
67JAK21.01897471
68MET1.00360132
69MAPK151.00062494
70CSNK1A1L1.00002098
71TIE10.98693331
72JAK10.97697973
73EPHA30.97169011
74SCYL20.96576947
75PLK10.94263984
76MAP3K70.94152759
77PRKAA10.92457544
78PLK40.91942005
79PRKCE0.87716234
80DYRK30.86593819
81MAPK40.86242885
82ERBB20.85817217
83CCNB10.84868195
84CAMK2D0.82416922
85MAP2K30.81836746
86WNK30.81768782
87PRKCZ0.80908978
88SGK30.80582794
89PRKACG0.79351883
90MAP3K140.75904832
91SGK20.75879040
92ZAK0.74311194
93PDK20.71389331
94MAP3K120.71269598
95CDK60.71220220
96CDK190.70942387
97GSK3A0.70429337
98MAPK120.69418647
99STK240.68979077
100MAP3K30.68681825
101FGFR30.67059598
102SGK4940.65846345
103SGK2230.65846345
104IRAK10.65473627
105NEK10.65008650
106GRK10.64869901
107CAMK2G0.63322917
108TGFBR20.62586708
109MAP3K20.61329890
110AKT20.61253062
111GRK60.60196176
112WNK40.59728957
113FGFR10.59008413
114MUSK0.58566446
115TBK10.58208313
116PDPK10.56839665
117ATM0.56585539
118IGF1R0.54326306
119MAP2K10.53434164
120YES10.52264056
121NME10.51586764
122PIK3CA0.51373099
123EPHB10.51182522
124FER0.51048109
125CSNK1E0.49877323
126AURKB0.49843686
127MAP3K110.49662579
128LATS20.49330303
129NTRK30.48976365
130CSNK1G10.48316472
131CAMK1G0.47255230
132MAP2K70.47146757
133IRAK20.45666133
134AKT30.45343596
135MAPKAPK50.44417406
136EIF2AK20.44409538
137OBSCN0.44206317
138MAP3K50.44162516
139MAPK70.43822389
140NLK0.42567639
141PRKCQ0.42089842
142EPHA20.41503652
143PRKCG0.40302957
144MAP2K60.40028858
145RPS6KB10.38820306
146LMTK20.38330050
147EPHB20.37464414
148LIMK10.37448076
149CSK0.36964049
150CSNK1A10.36629907
151STK30.36096794
152PTK20.35612572
153MTOR0.33883148
154DYRK1B0.33018902
155CDK40.32341632
156OXSR10.31666476
157PAK30.29911697
158PDK10.29717740
159PRKCA0.29698119
160MAP3K100.26164553
161RET0.25944244
162PRKACA0.25828394
163NUAK10.24278416
164MYLK0.24274850
165CSF1R0.22502055
166PRKACB0.21945275

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.19456024
2Nitrogen metabolism_Homo sapiens_hsa009103.37777245
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19171767
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18496300
5Arginine biosynthesis_Homo sapiens_hsa002202.90338876
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.74938470
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.73336982
8Fatty acid degradation_Homo sapiens_hsa000712.72900974
9Tryptophan metabolism_Homo sapiens_hsa003802.66722386
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.65077347
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44995179
12Complement and coagulation cascades_Homo sapiens_hsa046102.44187883
13Propanoate metabolism_Homo sapiens_hsa006402.35251599
14Butanoate metabolism_Homo sapiens_hsa006502.27558071
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23814522
16* Peroxisome_Homo sapiens_hsa041462.12754275
17Fatty acid metabolism_Homo sapiens_hsa012122.08404516
18PPAR signaling pathway_Homo sapiens_hsa033202.01891831
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.01480274
20beta-Alanine metabolism_Homo sapiens_hsa004101.85289981
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84738243
22Chemical carcinogenesis_Homo sapiens_hsa052041.81898763
23Histidine metabolism_Homo sapiens_hsa003401.80979748
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.80841232
25Protein export_Homo sapiens_hsa030601.80139729
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.79821401
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72944194
28Caffeine metabolism_Homo sapiens_hsa002321.68176495
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67971504
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.67743876
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67478027
32Retinol metabolism_Homo sapiens_hsa008301.67349821
33Pyruvate metabolism_Homo sapiens_hsa006201.57030423
34Phenylalanine metabolism_Homo sapiens_hsa003601.56847319
35Fatty acid elongation_Homo sapiens_hsa000621.52523925
36Staphylococcus aureus infection_Homo sapiens_hsa051501.50215540
37Selenocompound metabolism_Homo sapiens_hsa004501.45048491
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44897889
39Tyrosine metabolism_Homo sapiens_hsa003501.44443693
40Bile secretion_Homo sapiens_hsa049761.44384051
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37556657
42Carbon metabolism_Homo sapiens_hsa012001.31279764
43Sulfur metabolism_Homo sapiens_hsa009201.30734063
44Starch and sucrose metabolism_Homo sapiens_hsa005001.30574806
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.27093260
46Biosynthesis of amino acids_Homo sapiens_hsa012301.22983317
47Fat digestion and absorption_Homo sapiens_hsa049751.18292860
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18227918
49Folate biosynthesis_Homo sapiens_hsa007901.17080927
50ABC transporters_Homo sapiens_hsa020101.16060473
51Non-homologous end-joining_Homo sapiens_hsa034501.11676079
52Steroid biosynthesis_Homo sapiens_hsa001001.10333773
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.10222217
54Mismatch repair_Homo sapiens_hsa034301.06229061
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03722005
56Arginine and proline metabolism_Homo sapiens_hsa003301.01850547
57Vitamin B6 metabolism_Homo sapiens_hsa007501.01631340
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97192082
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.95887646
60Vitamin digestion and absorption_Homo sapiens_hsa049770.95638530
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93668244
62Lysine degradation_Homo sapiens_hsa003100.84884994
63Glycerolipid metabolism_Homo sapiens_hsa005610.83438729
64Sulfur relay system_Homo sapiens_hsa041220.81691084
65Parkinsons disease_Homo sapiens_hsa050120.80685029
66Fatty acid biosynthesis_Homo sapiens_hsa000610.76710750
67* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75695943
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74271193
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72165347
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71298540
71Cardiac muscle contraction_Homo sapiens_hsa042600.69050318
72Glutathione metabolism_Homo sapiens_hsa004800.68122862
73Insulin secretion_Homo sapiens_hsa049110.67574550
74One carbon pool by folate_Homo sapiens_hsa006700.66323337
75Basal transcription factors_Homo sapiens_hsa030220.66125043
76RNA degradation_Homo sapiens_hsa030180.63721631
77Huntingtons disease_Homo sapiens_hsa050160.63397190
78Homologous recombination_Homo sapiens_hsa034400.62237189
79Fanconi anemia pathway_Homo sapiens_hsa034600.61795689
80Nucleotide excision repair_Homo sapiens_hsa034200.60995026
81Pentose phosphate pathway_Homo sapiens_hsa000300.60903747
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59914201
83Proteasome_Homo sapiens_hsa030500.59889602
84Alzheimers disease_Homo sapiens_hsa050100.59453637
85RNA transport_Homo sapiens_hsa030130.57500520
86Tight junction_Homo sapiens_hsa045300.55548470
87* Metabolic pathways_Homo sapiens_hsa011000.52124541
88Oocyte meiosis_Homo sapiens_hsa041140.44291610
89Purine metabolism_Homo sapiens_hsa002300.41144980
90TGF-beta signaling pathway_Homo sapiens_hsa043500.40670600
91Pancreatic secretion_Homo sapiens_hsa049720.39474296
92Hippo signaling pathway_Homo sapiens_hsa043900.36861206
93RNA polymerase_Homo sapiens_hsa030200.36656664
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34392648
95Sphingolipid metabolism_Homo sapiens_hsa006000.33787791
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31355849
97Fructose and mannose metabolism_Homo sapiens_hsa000510.30753611
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.29497560
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28759326
100Galactose metabolism_Homo sapiens_hsa000520.26564564
101Insulin resistance_Homo sapiens_hsa049310.24417746
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23962366
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.22757296
104Prion diseases_Homo sapiens_hsa050200.21179867
105Linoleic acid metabolism_Homo sapiens_hsa005910.19895542
106Glucagon signaling pathway_Homo sapiens_hsa049220.13666313
107AMPK signaling pathway_Homo sapiens_hsa041520.08671641
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08471539
109Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2346194
110Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2333932
111Circadian rhythm_Homo sapiens_hsa04710-0.2301821
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2296714
113Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2268974
114Hepatitis C_Homo sapiens_hsa05160-0.2183555
115Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2118295
116Protein digestion and absorption_Homo sapiens_hsa04974-0.2018138
117Oxidative phosphorylation_Homo sapiens_hsa00190-0.2005546
118Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1873382
119Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1807701
120Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1778331
121Mineral absorption_Homo sapiens_hsa04978-0.1620598
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1426857
123Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0986537
124Renin-angiotensin system_Homo sapiens_hsa04614-0.0831232
125Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0662867
126Insulin signaling pathway_Homo sapiens_hsa04910-0.0621954
127Regulation of autophagy_Homo sapiens_hsa04140-0.0451644
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0190594

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