NUDT14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.88063860
2viral transcription (GO:0019083)5.92935842
3ribosomal small subunit biogenesis (GO:0042274)5.75439137
4translational termination (GO:0006415)5.71265215
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.52686292
6cotranslational protein targeting to membrane (GO:0006613)5.43781804
7protein targeting to ER (GO:0045047)5.39468196
8DNA deamination (GO:0045006)5.21965267
9translational elongation (GO:0006414)5.12268221
10protein localization to endoplasmic reticulum (GO:0070972)5.10556572
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.08086964
12regulation of autophagic vacuole assembly (GO:2000785)4.78601690
13maturation of SSU-rRNA (GO:0030490)4.66803952
14histone arginine methylation (GO:0034969)4.60745045
15viral life cycle (GO:0019058)4.57459339
16cellular protein complex disassembly (GO:0043624)4.35375340
17translational initiation (GO:0006413)4.26459645
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.24994314
19deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.22301091
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.14224198
21regulation of vacuole organization (GO:0044088)4.06733009
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.04296375
23ATP synthesis coupled proton transport (GO:0015986)4.04296375
24telomere maintenance via semi-conservative replication (GO:0032201)3.96574290
25ribosomal large subunit biogenesis (GO:0042273)3.93028707
26translation (GO:0006412)3.92715928
27DNA strand elongation (GO:0022616)3.90258082
28DNA strand elongation involved in DNA replication (GO:0006271)3.87418002
29protein complex disassembly (GO:0043241)3.81779133
30energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.78341727
31ATP hydrolysis coupled proton transport (GO:0015991)3.78341727
32GTP biosynthetic process (GO:0006183)3.71970624
33macromolecular complex disassembly (GO:0032984)3.67480143
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.66718980
35NADH dehydrogenase complex assembly (GO:0010257)3.66718980
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.66718980
37regulation of cilium movement (GO:0003352)3.62599584
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.53864245
39formation of translation preinitiation complex (GO:0001731)3.47931993
40respiratory chain complex IV assembly (GO:0008535)3.47867667
41synaptic vesicle exocytosis (GO:0016079)3.47772803
42telomere maintenance via recombination (GO:0000722)3.45204316
43protein targeting to membrane (GO:0006612)3.45046913
44proteasome assembly (GO:0043248)3.44833579
45establishment of integrated proviral latency (GO:0075713)3.41969938
46mitochondrial respiratory chain complex assembly (GO:0033108)3.41263027
47response to misfolded protein (GO:0051788)3.39266656
48protein complex biogenesis (GO:0070271)3.39030932
49UTP biosynthetic process (GO:0006228)3.38228703
50ribonucleoprotein complex biogenesis (GO:0022613)3.36331523
51nuclear-transcribed mRNA catabolic process (GO:0000956)3.34932972
52axonemal dynein complex assembly (GO:0070286)3.31618374
53guanosine-containing compound biosynthetic process (GO:1901070)3.29215354
54protein polyglutamylation (GO:0018095)3.28170118
55axoneme assembly (GO:0035082)3.27337060
56protein insertion into membrane (GO:0051205)3.27190821
57chaperone-mediated protein transport (GO:0072321)3.26182220
58pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.23693406
59negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.22411989
60oxidative phosphorylation (GO:0006119)3.21710471
61CTP biosynthetic process (GO:0006241)3.21270052
62CTP metabolic process (GO:0046036)3.21270052
63mRNA catabolic process (GO:0006402)3.19908719
64regulation of microtubule-based movement (GO:0060632)3.19882566
65pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.18467368
66DNA replication initiation (GO:0006270)3.18124144
67pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.17317081
68pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.15925819
69transcription elongation from RNA polymerase III promoter (GO:0006385)3.13124612
70termination of RNA polymerase III transcription (GO:0006386)3.13124612
71protein deneddylation (GO:0000338)3.11842257
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.10769781
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10713396
74cellular component biogenesis (GO:0044085)3.10250234
75viral mRNA export from host cell nucleus (GO:0046784)3.10028326
76L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.09980569
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07326448
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07326448
79signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05923704
80signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05923704
81signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05923704
82UTP metabolic process (GO:0046051)3.02194289
83mitotic recombination (GO:0006312)3.01571593
84ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.00332843
85telomere maintenance via telomere lengthening (GO:0010833)3.00324673
86pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.99906015
87pseudouridine synthesis (GO:0001522)2.99865701
88transferrin transport (GO:0033572)2.99683824
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99590766
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99366623
91mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.98812175
92RNA catabolic process (GO:0006401)2.98532434
93respiratory electron transport chain (GO:0022904)2.97423195
94signal transduction involved in DNA damage checkpoint (GO:0072422)2.94472150
95signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94472150
96regulation of cellular amino acid metabolic process (GO:0006521)2.94425417
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.94205541
98electron transport chain (GO:0022900)2.94104458
99antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.91989493
100negative regulation of ligase activity (GO:0051352)2.91015622
101negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.91015622
102signal peptide processing (GO:0006465)2.90770154
103signal transduction involved in cell cycle checkpoint (GO:0072395)2.90710573
104positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.90308844
105pyrimidine nucleobase catabolic process (GO:0006208)2.90163014
106pyrimidine nucleoside biosynthetic process (GO:0046134)2.89759734
107metallo-sulfur cluster assembly (GO:0031163)2.89625540
108iron-sulfur cluster assembly (GO:0016226)2.89625540
109rRNA processing (GO:0006364)2.89271345
110nucleotide-excision repair, DNA gap filling (GO:0006297)2.88719061
111cullin deneddylation (GO:0010388)2.88671413
112regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.87950014
113dendritic spine morphogenesis (GO:0060997)2.87676191
114transcription-coupled nucleotide-excision repair (GO:0006283)2.87644628
115rRNA modification (GO:0000154)2.87484493
116response to interferon-beta (GO:0035456)2.85547484
117base-excision repair, AP site formation (GO:0006285)2.85167649
1187-methylguanosine mRNA capping (GO:0006370)2.82958714
119deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.82526873
120establishment of viral latency (GO:0019043)2.80725517
121pteridine-containing compound biosynthetic process (GO:0042559)2.80365763
122ferric iron transport (GO:0015682)2.77278539
123trivalent inorganic cation transport (GO:0072512)2.77278539
124positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.76927072
125behavioral response to nicotine (GO:0035095)2.76001889
126mannosylation (GO:0097502)2.75625414
127ubiquinone biosynthetic process (GO:0006744)2.72241511
128platelet dense granule organization (GO:0060155)2.71830387
129hydrogen ion transmembrane transport (GO:1902600)2.71260655
130cellular anion homeostasis (GO:0030002)2.68334786
131phosphatidylglycerol biosynthetic process (GO:0006655)2.65783279
132epithelial cilium movement (GO:0003351)2.64862867
133trivalent inorganic anion homeostasis (GO:0072506)2.63784236
134phosphate ion homeostasis (GO:0055062)2.63784236
135response to dietary excess (GO:0002021)2.63651635
136motile cilium assembly (GO:0044458)2.63531982
137cofactor catabolic process (GO:0051187)2.62754790
138positive regulation of prostaglandin secretion (GO:0032308)2.60428292
139positive regulation of mitochondrial fission (GO:0090141)2.60134484
140synaptic vesicle maturation (GO:0016188)2.59347296
141positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.59107348
142positive regulation of neurotransmitter secretion (GO:0001956)2.58096449
143arginine catabolic process (GO:0006527)2.57665802
144proton transport (GO:0015992)2.57256860
145nucleobase catabolic process (GO:0046113)2.57117203
146phagosome maturation (GO:0090382)2.57085149
147dendritic spine organization (GO:0097061)2.56703049
148nitric oxide biosynthetic process (GO:0006809)2.56531399
149glutathione biosynthetic process (GO:0006750)2.55304374
150hydrogen transport (GO:0006818)2.52154417
151purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.50367745
152glycerophospholipid catabolic process (GO:0046475)2.49635000
153C-terminal protein lipidation (GO:0006501)2.47925474
154purine nucleoside triphosphate biosynthetic process (GO:0009145)2.47603281
155collecting duct development (GO:0072044)2.47530038
156amyloid precursor protein catabolic process (GO:0042987)2.47222191
157cilium movement (GO:0003341)2.46365372
158nucleoside diphosphate phosphorylation (GO:0006165)2.45516217
159GDP-mannose metabolic process (GO:0019673)2.44103790
160purine ribonucleoside diphosphate metabolic process (GO:0009179)2.43892391
161purine nucleoside diphosphate metabolic process (GO:0009135)2.43892391
162positive regulation of neurotransmitter transport (GO:0051590)2.43233069
163peroxisome fission (GO:0016559)2.43090296
164nonribosomal peptide biosynthetic process (GO:0019184)2.40896829
165L-methionine salvage (GO:0071267)2.39756978
166L-methionine biosynthetic process (GO:0071265)2.39756978
167amino acid salvage (GO:0043102)2.39756978
168ubiquinone metabolic process (GO:0006743)2.37242486
169protein maturation by protein folding (GO:0022417)2.37011338
170neurotransmitter-gated ion channel clustering (GO:0072578)2.33900811
171tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.33571992
172RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.33571992
173positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.31915624
174ATP biosynthetic process (GO:0006754)2.30963195
175C-terminal protein amino acid modification (GO:0018410)2.28988871
176protein localization to cilium (GO:0061512)2.28956256
177quinone metabolic process (GO:1901661)2.28824772
178mitochondrial calcium ion homeostasis (GO:0051560)2.28551706
179cellular biogenic amine catabolic process (GO:0042402)2.27898438
180amine catabolic process (GO:0009310)2.27898438

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.82847892
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.05128512
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.02378159
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.88342090
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.60968067
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.59836746
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.54311780
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.47233552
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.14126641
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.13577633
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.01600345
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94379338
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.84570335
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82168339
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.81574997
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66316869
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.60247026
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57464657
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.54565859
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51303225
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44666239
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.43809483
23VDR_23849224_ChIP-Seq_CD4+_Human2.43590467
24XRN2_22483619_ChIP-Seq_HELA_Human2.42185697
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.41873055
26* SRF_21415370_ChIP-Seq_HL-1_Mouse2.30717227
27* LXR_22292898_ChIP-Seq_THP-1_Human2.29416453
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26869928
29TET1_21451524_ChIP-Seq_MESCs_Mouse2.25738433
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.23183367
31DCP1A_22483619_ChIP-Seq_HELA_Human2.20711684
32FOXP3_21729870_ChIP-Seq_TREG_Human2.14351822
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.11065878
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04886870
35P68_20966046_ChIP-Seq_HELA_Human2.02541341
36NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01607538
37IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00609928
38E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00562066
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.00431186
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.98268241
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97932464
42GABP_19822575_ChIP-Seq_HepG2_Human1.96419676
43BCL6_27268052_Chip-Seq_Bcells_Human1.95692371
44TTF2_22483619_ChIP-Seq_HELA_Human1.95034295
45CTCF_27219007_Chip-Seq_Bcells_Human1.93562039
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.92000889
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.91949788
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.91124554
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.87757916
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84468345
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78406028
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.76947084
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73418724
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.68884259
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.65173221
56CTCF_20526341_ChIP-Seq_ESCs_Human1.64109693
57ELK1_19687146_ChIP-ChIP_HELA_Human1.63803242
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60919241
59PHF8_20622854_ChIP-Seq_HELA_Human1.59805204
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59478098
61BCOR_27268052_Chip-Seq_Bcells_Human1.57168381
62SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56137312
63E2F1_20622854_ChIP-Seq_HELA_Human1.55222467
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.54055982
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53076060
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.52761079
67SA1_27219007_Chip-Seq_Bcells_Human1.52581041
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52146508
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51619312
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.48318808
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.46641079
72* EZH2_27294783_Chip-Seq_ESCs_Mouse1.46040632
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45957421
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45422726
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.45365997
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45074862
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44640778
78FOXP1_21924763_ChIP-Seq_HESCs_Human1.43027321
79RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.43012424
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42675343
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.42660827
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42113796
83CTCF_26484167_Chip-Seq_Bcells_Mouse1.42057753
84SMC4_20622854_ChIP-Seq_HELA_Human1.40712762
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.37443505
86* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36881408
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.36866584
88CIITA_25753668_ChIP-Seq_RAJI_Human1.36767729
89RAD21_21589869_ChIP-Seq_MESCs_Mouse1.34473862
90STAT1_20625510_ChIP-Seq_HELA_Human1.33857129
91RARB_24833708_ChIP-Seq_LIVER_Mouse1.33086217
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32638856
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32092613
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.28554684
95REST_21632747_ChIP-Seq_MESCs_Mouse1.26102012
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24726827
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23235585
98NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22791401
99RACK7_27058665_Chip-Seq_MCF-7_Human1.22522630
100ERA_21632823_ChIP-Seq_H3396_Human1.20210093
101EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.20120450
102OCT4_20526341_ChIP-Seq_ESCs_Human1.19937926
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17998867
104* MYC_18940864_ChIP-ChIP_HL60_Human1.17719922
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16916037
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16257043
107TET1_21490601_ChIP-Seq_MESCs_Mouse1.16236200
108ELK1_22589737_ChIP-Seq_MCF10A_Human1.15728984
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.15668847
110SPI1_23547873_ChIP-Seq_NB4_Human1.15086066
111SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.14655434
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14006561
113* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13029458
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13014946
115TP63_17297297_ChIP-ChIP_HaCaT_Human1.12785327
116SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12777516
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12513695
118ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11450679
119KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11164170
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09894914
121RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08940616
122P300_27268052_Chip-Seq_Bcells_Human1.08913415
123RARA_24833708_ChIP-Seq_LIVER_Mouse1.07679341
124* TP63_22573176_ChIP-Seq_HFKS_Human1.07234443
125SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07135850
126TAF2_19829295_ChIP-Seq_ESCs_Human1.05997203
127BP1_19119308_ChIP-ChIP_Hs578T_Human1.05470604
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04457895
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04354848
130LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02965785
131RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02262788
132HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01578871
133SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00556645
134YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99862574
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99405341
136CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99330250
137TP53_20018659_ChIP-ChIP_R1E_Mouse0.98337451
138DROSHA_22980978_ChIP-Seq_HELA_Human0.98136988
139NANOG_20526341_ChIP-Seq_ESCs_Human0.97714478
140MYC_19829295_ChIP-Seq_ESCs_Human0.97683194
141FOXH1_21741376_ChIP-Seq_ESCs_Human0.97410924
142CREB1_26743006_Chip-Seq_LNCaP_Human0.97373341
143* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96599483
144SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96361334
145E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95601653
146CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95595497
147NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95312233
148MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95217050
149STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94728716
150FLI1_21867929_ChIP-Seq_CD8_Mouse0.94602664
151VDR_21846776_ChIP-Seq_THP-1_Human0.93775094
152ELK3_25401928_ChIP-Seq_HUVEC_Human0.93562878
153ZNF263_19887448_ChIP-Seq_K562_Human0.93425462
154CTCF_21964334_ChIP-Seq_BJAB-B_Human0.93392307
155SOX2_21211035_ChIP-Seq_LN229_Human0.93326891
156RAC3_21632823_ChIP-Seq_H3396_Human0.93243975
157E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92526996
158TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92438435
159STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92399836
160CTCF_21964334_Chip-Seq_Bcells_Human0.92298345
161ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91124937
162MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89848144
163LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89431405
164KDM5A_27292631_Chip-Seq_BREAST_Human0.88521725
165GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88409827
166EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84279740
167FOXM1_23109430_ChIP-Seq_U2OS_Human0.83354757
168PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80813423
169IRF1_19129219_ChIP-ChIP_H3396_Human0.80779463
170* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80044279
171ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79138226
172YY1_22570637_ChIP-Seq_MALME-3M_Human0.78875281
173MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.78718112
174PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77865115
175SCL_19346495_ChIP-Seq_HPC-7_Human0.77634908

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.61276297
2MP0005058_abnormal_lysosome_morphology3.51194260
3MP0003693_abnormal_embryo_hatching3.35270857
4MP0002653_abnormal_ependyma_morphology3.15813630
5MP0003806_abnormal_nucleotide_metabolis2.72244207
6MP0003186_abnormal_redox_activity2.58197021
7MP0004957_abnormal_blastocyst_morpholog2.51458274
8MP0003879_abnormal_hair_cell2.48644190
9MP0001984_abnormal_olfaction2.47847936
10MP0010094_abnormal_chromosome_stability2.38794384
11MP0006276_abnormal_autonomic_nervous2.28066003
12MP0009840_abnormal_foam_cell2.12671306
13MP0003172_abnormal_lysosome_physiology2.11678189
14MP0009046_muscle_twitch2.10930874
15MP0008058_abnormal_DNA_repair2.09310489
16MP0003763_abnormal_thymus_physiology2.06855966
17MP0001529_abnormal_vocalization2.01953315
18MP0001968_abnormal_touch/_nociception1.99419626
19MP0002132_abnormal_respiratory_system1.97546713
20MP0004270_analgesia1.97317606
21MP0003315_abnormal_perineum_morphology1.97216280
22MP0004859_abnormal_synaptic_plasticity1.93454141
23MP0003077_abnormal_cell_cycle1.92631616
24MP0003787_abnormal_imprinting1.92247546
25MP0002736_abnormal_nociception_after1.91311608
26MP0001905_abnormal_dopamine_level1.91220650
27MP0008057_abnormal_DNA_replication1.90885638
28MP0008007_abnormal_cellular_replicative1.88754993
29MP0002837_dystrophic_cardiac_calcinosis1.87515863
30MP0004264_abnormal_extraembryonic_tissu1.86473282
31MP0005220_abnormal_exocrine_pancreas1.85659504
32MP0001835_abnormal_antigen_presentation1.85326131
33MP0002909_abnormal_adrenal_gland1.83646376
34MP0010030_abnormal_orbit_morphology1.82880757
35MP0000490_abnormal_crypts_of1.81722731
36MP0005379_endocrine/exocrine_gland_phen1.81120434
37MP0003122_maternal_imprinting1.79059577
38MP0003880_abnormal_central_pattern1.76873638
39MP0005084_abnormal_gallbladder_morpholo1.74805827
40MP0003786_premature_aging1.73851260
41MP0002877_abnormal_melanocyte_morpholog1.72749468
42MP0009785_altered_susceptibility_to1.72536986
43MP0008932_abnormal_embryonic_tissue1.70588255
44MP0002396_abnormal_hematopoietic_system1.67611767
45MP0001986_abnormal_taste_sensitivity1.67304178
46MP0004782_abnormal_surfactant_physiolog1.63570936
47MP0001970_abnormal_pain_threshold1.58769129
48MP0003329_amyloid_beta_deposits1.58589301
49MP0002064_seizures1.56934272
50MP0003137_abnormal_impulse_conducting1.56166569
51MP0005499_abnormal_olfactory_system1.56081977
52MP0005394_taste/olfaction_phenotype1.56081977
53MP0000538_abnormal_urinary_bladder1.55751513
54MP0005377_hearing/vestibular/ear_phenot1.53684651
55MP0003878_abnormal_ear_physiology1.53684651
56MP0005408_hypopigmentation1.53618729
57MP0009745_abnormal_behavioral_response1.52832266
58MP0002876_abnormal_thyroid_physiology1.51439744
59MP0003111_abnormal_nucleus_morphology1.50913072
60MP0001502_abnormal_circadian_rhythm1.49805160
61MP0002272_abnormal_nervous_system1.49421333
62MP0002733_abnormal_thermal_nociception1.45305183
63MP0005083_abnormal_biliary_tract1.44612651
64MP0002572_abnormal_emotion/affect_behav1.44583299
65MP0009780_abnormal_chondrocyte_physiolo1.44482387
66MP0005075_abnormal_melanosome_morpholog1.44407744
67MP0004133_heterotaxia1.44059089
68MP0003635_abnormal_synaptic_transmissio1.43361690
69MP0005671_abnormal_response_to1.41775061
70MP0002277_abnormal_respiratory_mucosa1.41326628
71MP0003011_delayed_dark_adaptation1.40541842
72MP0009697_abnormal_copulation1.39856301
73MP0006036_abnormal_mitochondrial_physio1.39790254
74MP0000685_abnormal_immune_system1.38379012
75MP0002090_abnormal_vision1.38096742
76MP0008995_early_reproductive_senescence1.38046622
77MP0002148_abnormal_hypersensitivity_rea1.36801417
78MP0002734_abnormal_mechanical_nocicepti1.36255348
79MP0004510_myositis1.34197288
80MP0009333_abnormal_splenocyte_physiolog1.32473486
81MP0001727_abnormal_embryo_implantation1.32248345
82MP0005360_urolithiasis1.31543394
83MP0010155_abnormal_intestine_physiology1.30900410
84MP0005551_abnormal_eye_electrophysiolog1.30703084
85MP0006292_abnormal_olfactory_placode1.30316142
86MP0003724_increased_susceptibility_to1.29716123
87MP0000372_irregular_coat_pigmentation1.28975663
88MP0002557_abnormal_social/conspecific_i1.27597787
89MP0002102_abnormal_ear_morphology1.26967080
90MP0002063_abnormal_learning/memory/cond1.25360872
91MP0002166_altered_tumor_susceptibility1.23943975
92MP0005167_abnormal_blood-brain_barrier1.23774592
93MP0002822_catalepsy1.22732833
94MP0002006_tumorigenesis1.22406305
95MP0005025_abnormal_response_to1.21558832
96MP0000678_abnormal_parathyroid_gland1.20858859
97MP0005174_abnormal_tail_pigmentation1.20549332
98MP0008789_abnormal_olfactory_epithelium1.19894054
99MP0006054_spinal_hemorrhage1.19484760
100MP0002229_neurodegeneration1.19173730
101MP0001764_abnormal_homeostasis1.19019855
102MP0003718_maternal_effect1.17591346
103MP0002938_white_spotting1.16048641
104MP0001501_abnormal_sleep_pattern1.15835055
105MP0004924_abnormal_behavior1.14907413
106MP0005386_behavior/neurological_phenoty1.14907413
107MP0001486_abnormal_startle_reflex1.12210832
108MP0004142_abnormal_muscle_tone1.11848858
109MP0006072_abnormal_retinal_apoptosis1.11498026
110MP0003075_altered_response_to1.08459447
111MP0002693_abnormal_pancreas_physiology1.07128935
112MP0003866_abnormal_defecation1.05797110
113MP0002098_abnormal_vibrissa_morphology1.05434287
114MP0000750_abnormal_muscle_regeneration1.05183189
115MP0001346_abnormal_lacrimal_gland1.04592443
116MP0004019_abnormal_vitamin_homeostasis1.04438977
117MP0005332_abnormal_amino_acid1.03655519
118MP0002009_preneoplasia1.03632363
119MP0002638_abnormal_pupillary_reflex1.02875565
120MP0003436_decreased_susceptibility_to1.02602716
121MP0005645_abnormal_hypothalamus_physiol1.02183250
122MP0000313_abnormal_cell_death1.00931426
123MP0002398_abnormal_bone_marrow1.00116008
124MP0001666_abnormal_nutrient_absorption0.99879411
125MP0002019_abnormal_tumor_incidence0.99611725
126MP0000604_amyloidosis0.98642939
127MP0003890_abnormal_embryonic-extraembry0.98331674
128MP0001853_heart_inflammation0.98289314
129MP0001800_abnormal_humoral_immune0.97065901
130MP0003121_genomic_imprinting0.96517790
131MP0004742_abnormal_vestibular_system0.96364277
132MP0001944_abnormal_pancreas_morphology0.96293489
133MP0002751_abnormal_autonomic_nervous0.96289854
134MP0005000_abnormal_immune_tolerance0.95771596
135MP0002405_respiratory_system_inflammati0.95336637
136MP0002723_abnormal_immune_serum0.95272250
137MP0002420_abnormal_adaptive_immunity0.95206889
138MP0001819_abnormal_immune_cell0.94873214
139MP0003943_abnormal_hepatobiliary_system0.94252366
140MP0000858_altered_metastatic_potential0.94025807
141MP0006082_CNS_inflammation0.93991335
142MP0000689_abnormal_spleen_morphology0.93881226
143MP0002722_abnormal_immune_system0.93380937
144MP0003633_abnormal_nervous_system0.93097835
145MP0002139_abnormal_hepatobiliary_system0.92713479
146MP0002429_abnormal_blood_cell0.92349904
147MP0001756_abnormal_urination0.92276274
148MP0004147_increased_porphyrin_level0.92023250
149MP0010234_abnormal_vibrissa_follicle0.91253852
150MP0005646_abnormal_pituitary_gland0.90468004
151MP0002067_abnormal_sensory_capabilities0.89896940
152MP0010386_abnormal_urinary_bladder0.89830360
153MP0001845_abnormal_inflammatory_respons0.89688890
154MP0008875_abnormal_xenobiotic_pharmacok0.89110419
155MP0000716_abnormal_immune_system0.88981573
156MP0000613_abnormal_salivary_gland0.88976468
157MP0000681_abnormal_thyroid_gland0.88919339
158MP0004381_abnormal_hair_follicle0.88896658
159MP0000343_altered_response_to0.88839730
160MP0002452_abnormal_antigen_presenting0.88650154
161MP0000566_synostosis0.87890885
162MP0002095_abnormal_skin_pigmentation0.87213238
163MP0009643_abnormal_urine_homeostasis0.87203100
164MP0002882_abnormal_neuron_morphology0.87167797
165MP0004043_abnormal_pH_regulation0.85406239
166MP0005253_abnormal_eye_physiology0.84913418
167MP0002163_abnormal_gland_morphology0.84568429
168MP0001963_abnormal_hearing_physiology0.84265794
169MP0005670_abnormal_white_adipose0.82692732
170MP0008872_abnormal_physiological_respon0.81441361
171MP0001664_abnormal_digestion0.80393786
172MP0005535_abnormal_body_temperature0.79179112
173MP0002735_abnormal_chemical_nociception0.78931838
174MP0006035_abnormal_mitochondrial_morpho0.78921930
175MP0000026_abnormal_inner_ear0.78836720
176MP0001119_abnormal_female_reproductive0.78656458
177MP0003136_yellow_coat_color0.78541046
178MP0002066_abnormal_motor_capabilities/c0.78015965
179MP0003123_paternal_imprinting0.77961324
180MP0000049_abnormal_middle_ear0.76951247
181MP0001663_abnormal_digestive_system0.76848892
182MP0000703_abnormal_thymus_morphology0.76655133
183MP0001873_stomach_inflammation0.75628622
184MP0005636_abnormal_mineral_homeostasis0.75377247
185MP0005266_abnormal_metabolism0.75025533

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.53805888
2Abnormal number of erythroid precursors (HP:0012131)5.16189920
3Reticulocytopenia (HP:0001896)4.73269252
4Abnormality of liposaccharide metabolism (HP:0010968)4.59259169
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.59259169
6Abnormality of glycolipid metabolism (HP:0010969)4.59259169
7Acute necrotizing encephalopathy (HP:0006965)4.03494624
8Mitochondrial inheritance (HP:0001427)4.02943702
9Hepatocellular necrosis (HP:0001404)3.92672456
10Hepatic necrosis (HP:0002605)3.70419257
11Abnormal mitochondria in muscle tissue (HP:0008316)3.66925209
12Increased cerebral lipofuscin (HP:0011813)3.62095607
13Increased neuronal autofluorescent lipopigment (HP:0002074)3.61830784
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.60093159
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.60093159
16Agitation (HP:0000713)3.55657137
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.54139143
18Increased hepatocellular lipid droplets (HP:0006565)3.48802497
19Acute encephalopathy (HP:0006846)3.42349419
20Macrocytic anemia (HP:0001972)3.41694546
21Lipid accumulation in hepatocytes (HP:0006561)3.39025982
22Increased CSF lactate (HP:0002490)3.38701730
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.33757830
24Polyphagia (HP:0002591)3.19954636
25Exertional dyspnea (HP:0002875)3.19636370
26Type I transferrin isoform profile (HP:0003642)3.14311739
27Aplasia/Hypoplasia of the sacrum (HP:0008517)3.13605478
28Pallor (HP:0000980)3.11107235
29Progressive macrocephaly (HP:0004481)3.08246206
303-Methylglutaconic aciduria (HP:0003535)3.04817904
31Exercise intolerance (HP:0003546)3.02217806
32Renal Fanconi syndrome (HP:0001994)2.96569656
33Increased serum lactate (HP:0002151)2.92042090
34Concave nail (HP:0001598)2.91806301
35Aplastic anemia (HP:0001915)2.88759000
36Abnormal respiratory epithelium morphology (HP:0012253)2.85240421
37Abnormal respiratory motile cilium morphology (HP:0005938)2.85240421
38Myokymia (HP:0002411)2.80335641
39Mutism (HP:0002300)2.77382373
40Abnormality of polysaccharide metabolism (HP:0011012)2.74508632
41Abnormality of glycosaminoglycan metabolism (HP:0004371)2.74508632
42Abnormality of mucopolysaccharide metabolism (HP:0011020)2.74508632
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.71570115
44IgM deficiency (HP:0002850)2.71507620
45Prolonged neonatal jaundice (HP:0006579)2.67830667
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.67144746
47Absent/shortened dynein arms (HP:0200106)2.67144746
48Increased intramyocellular lipid droplets (HP:0012240)2.67128518
49Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.64104153
50Lactic acidosis (HP:0003128)2.64012839
51Respiratory failure (HP:0002878)2.61072191
52Colon cancer (HP:0003003)2.60082927
53Visual hallucinations (HP:0002367)2.57633308
54Hyperthyroidism (HP:0000836)2.55912161
5511 pairs of ribs (HP:0000878)2.52328491
56Dysostosis multiplex (HP:0000943)2.50739914
57J-shaped sella turcica (HP:0002680)2.48383210
58Increased muscle lipid content (HP:0009058)2.46889224
59Abnormal protein N-linked glycosylation (HP:0012347)2.46135544
60Abnormal protein glycosylation (HP:0012346)2.46135544
61Abnormal glycosylation (HP:0012345)2.46135544
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.46135544
63Microretrognathia (HP:0000308)2.45818160
64Loss of speech (HP:0002371)2.45100718
65Retinal atrophy (HP:0001105)2.42673653
66Retinal dysplasia (HP:0007973)2.38902163
67Microvesicular hepatic steatosis (HP:0001414)2.37720497
68Abnormal respiratory motile cilium physiology (HP:0012261)2.37419919
69Hypokinesia (HP:0002375)2.34260376
70Failure to thrive in infancy (HP:0001531)2.33633462
71Poor suck (HP:0002033)2.30552524
72Cerebral edema (HP:0002181)2.29753241
73Abnormal hemoglobin (HP:0011902)2.29258251
74Respiratory difficulties (HP:0002880)2.29219429
75Elevated erythrocyte sedimentation rate (HP:0003565)2.28742789
76Mucopolysacchariduria (HP:0008155)2.28486090
77Urinary glycosaminoglycan excretion (HP:0003541)2.28486090
78Reduced antithrombin III activity (HP:0001976)2.25084336
79Thrombocytosis (HP:0001894)2.24730686
80Hand muscle atrophy (HP:0009130)2.24682135
81Abnormal ciliary motility (HP:0012262)2.22763973
82Abnormality of dental color (HP:0011073)2.19336749
83Stridor (HP:0010307)2.17396146
84Medial flaring of the eyebrow (HP:0010747)2.17342472
85Gait imbalance (HP:0002141)2.16670377
86Occipital encephalocele (HP:0002085)2.16529505
87Delayed CNS myelination (HP:0002188)2.16123306
88Oral leukoplakia (HP:0002745)2.14772905
89Type II lissencephaly (HP:0007260)2.13668451
90Diminished motivation (HP:0000745)2.13334728
91Progressive neurologic deterioration (HP:0002344)2.10152700
92Trismus (HP:0000211)2.09356616
93Chronic bronchitis (HP:0004469)2.06013818
94Opisthotonus (HP:0002179)2.04329292
95Poor head control (HP:0002421)2.01752394
96Amblyopia (HP:0000646)2.00740161
97Apathy (HP:0000741)1.99307358
98Abnormality of the anterior horn cell (HP:0006802)1.99186179
99Degeneration of anterior horn cells (HP:0002398)1.99186179
100Abnormality of urine glucose concentration (HP:0011016)1.98668789
101Glycosuria (HP:0003076)1.98668789
102Birth length less than 3rd percentile (HP:0003561)1.98538952
103Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.98099708
104Congenital primary aphakia (HP:0007707)1.97882498
105Nuclear cataract (HP:0100018)1.97110751
106Carpal bone hypoplasia (HP:0001498)1.97107249
107Axonal loss (HP:0003447)1.96837600
108Delusions (HP:0000746)1.96676358
109Restlessness (HP:0000711)1.95902439
110Aplasia/hypoplasia of the uterus (HP:0008684)1.95154332
111Absent thumb (HP:0009777)1.92746075
112Abnormality of renal resorption (HP:0011038)1.92672079
113Late onset (HP:0003584)1.92650399
114Sclerocornea (HP:0000647)1.91453753
115Upper limb amyotrophy (HP:0009129)1.90125867
116Distal upper limb amyotrophy (HP:0007149)1.90125867
117Type 2 muscle fiber atrophy (HP:0003554)1.89834583
118True hermaphroditism (HP:0010459)1.89067837
119Neutropenia (HP:0001875)1.88932162
120Neoplasm of the pancreas (HP:0002894)1.88094778
121Nephrogenic diabetes insipidus (HP:0009806)1.87371265
122Rough bone trabeculation (HP:0100670)1.86923561
123Abnormality of midbrain morphology (HP:0002418)1.86597608
124Molar tooth sign on MRI (HP:0002419)1.86597608
125Rhinitis (HP:0012384)1.85572703
126Sparse eyelashes (HP:0000653)1.85564507
127Abnormality of the pancreatic islet cells (HP:0006476)1.85079216
128Abnormality of endocrine pancreas physiology (HP:0012093)1.85079216
129Progressive microcephaly (HP:0000253)1.84858695
130Multiple enchondromatosis (HP:0005701)1.83821079
131Hyperphosphaturia (HP:0003109)1.81903894
132Emotional lability (HP:0000712)1.81501209
133Bulbar palsy (HP:0001283)1.81129034
134Ketosis (HP:0001946)1.79670692
135Ketoacidosis (HP:0001993)1.79431125
136Muscle fiber atrophy (HP:0100295)1.79030468
137Petechiae (HP:0000967)1.77198691
138Double outlet right ventricle (HP:0001719)1.76988808
139Congenital malformation of the right heart (HP:0011723)1.76988808
140Abnormality of aromatic amino acid family metabolism (HP:0004338)1.76937204
141Neoplasm of the colon (HP:0100273)1.75140648
142Truncus arteriosus (HP:0001660)1.75056475
143Ankle clonus (HP:0011448)1.74090249
144Supranuclear gaze palsy (HP:0000605)1.73974675
145Hypoplasia of the uterus (HP:0000013)1.72410298
146Tongue fasciculations (HP:0001308)1.72274443
147Biliary tract neoplasm (HP:0100574)1.72008919
148Intestinal atresia (HP:0011100)1.71985712
149Abnormal pancreas size (HP:0012094)1.71625474
150Vacuolated lymphocytes (HP:0001922)1.70255986
151Premature graying of hair (HP:0002216)1.69998011
152Abnormality of the preputium (HP:0100587)1.69779554
153Cleft eyelid (HP:0000625)1.68896147
154Pancytopenia (HP:0001876)1.68342243
155Optic disc pallor (HP:0000543)1.68108929
156Absent rod-and cone-mediated responses on ERG (HP:0007688)1.65637903
157Hypoplasia of the radius (HP:0002984)1.65220877
158Lymphoma (HP:0002665)1.64496301
159Generalized aminoaciduria (HP:0002909)1.63910194
160Bronchitis (HP:0012387)1.63127295
161Abnormality of T cell physiology (HP:0011840)1.62394629
162Stenosis of the external auditory canal (HP:0000402)1.62202107
163Abnormality of dicarboxylic acid metabolism (HP:0010995)1.60986986
164Dicarboxylic aciduria (HP:0003215)1.60986986
165Neoplasm of the rectum (HP:0100743)1.60475340
166Breast hypoplasia (HP:0003187)1.58993232
167Lethargy (HP:0001254)1.57138734
168Amniotic constriction ring (HP:0009775)1.56822852
169Abnormality of placental membranes (HP:0011409)1.56822852
170Hypochromic anemia (HP:0001931)1.55310458
171Pancreatic cysts (HP:0001737)1.55026527
172Autoimmune hemolytic anemia (HP:0001890)1.54021394
173Facial cleft (HP:0002006)1.53640541
174Hypoglycemic coma (HP:0001325)1.53336223

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.75857239
2MAP4K23.18487492
3NME23.16413424
4STK162.90113431
5WEE12.88798768
6VRK12.84734612
7BUB12.58733207
8PINK12.51677463
9ARAF2.51584654
10MAP2K72.49066771
11PASK2.44923104
12MAP3K32.14019161
13CSNK1G32.12779928
14LIMK12.04683306
15BCKDK1.96055963
16SRPK11.93916146
17RPS6KB21.92052049
18MAP4K11.88914550
19EIF2AK11.86130462
20MST41.85616397
21TESK21.85199992
22CSNK1G21.84951870
23CDK81.80409438
24CSNK1A1L1.78370335
25PIM21.77371384
26MAPKAPK31.76692132
27DYRK31.73955634
28ABL21.71493174
29TGFBR11.69730126
30VRK21.68189910
31FLT31.62583077
32IRAK41.56523810
33KDR1.55286587
34CASK1.53106095
35GRK71.52321821
36TAOK11.47753730
37PHKG21.44147436
38PHKG11.44147436
39RPS6KA41.42002960
40CSNK1G11.39817257
41BRSK21.39679978
42DAPK21.39678711
43TEC1.38220202
44MAPK151.37029887
45ACVR1B1.35375537
46PBK1.34412263
47PLK41.33499177
48BTK1.33300666
49NME11.32987146
50MARK11.28825726
51NLK1.28255339
52CAMKK21.26247034
53BMPR1B1.26156735
54TLK11.25106876
55CDC71.24799554
56PRKD31.22285555
57CDK71.19707254
58FRK1.18744734
59MYLK1.15261494
60MAP3K41.11428846
61ERN11.10842807
62DAPK11.07331457
63MAP3K111.06138510
64WNK31.04308476
65CAMKK11.01155364
66PRKD21.00115791
67EPHB20.98301940
68AURKB0.97273657
69CDK190.96855040
70MAP2K60.96800901
71KIT0.96186061
72ZAK0.93879182
73PLK10.93427509
74LRRK20.93415875
75DYRK20.93077226
76MAP2K30.91936663
77PKN20.91452051
78EIF2AK20.89818147
79ZAP700.88160429
80PAK30.87986904
81ATR0.87117850
82BMPR20.86510607
83TYK20.84466323
84MKNK10.81903473
85IRAK30.81644250
86ILK0.81420308
87CAMK2G0.80853479
88EEF2K0.80613451
89TXK0.77770193
90AURKA0.77391698
91CSNK1A10.77241897
92GRK50.75547778
93IKBKE0.75363503
94PAK60.75296594
95YES10.75214202
96MAP2K20.74953079
97NUAK10.74376995
98TESK10.73772390
99EPHB10.73109130
100PIK3CG0.72465809
101FER0.72323218
102GRK10.71055977
103PRKCG0.69572284
104CAMK10.68689728
105CSNK2A10.68143643
106WNK40.67746208
107MUSK0.67344901
108TNK20.66937308
109IKBKB0.66618681
110PIM10.65960300
111ADRBK20.65819638
112TBK10.64732825
113PRKCI0.64643486
114CDK140.64530270
115RPS6KA20.63367212
116PAK40.62277487
117MAPK130.62050533
118BRSK10.60663694
119CDK50.60391252
120PRKG20.60270757
121RPS6KA50.60095189
122STK38L0.59373529
123EPHA40.58023099
124IRAK20.57835097
125DYRK1B0.57175946
126MAP3K140.57128986
127DAPK30.56482718
128TRIB30.55135342
129TIE10.54544050
130HIPK20.54440338
131MAP3K120.54432157
132MAP2K40.53908359
133BRAF0.53303934
134TSSK60.53035362
135EPHA20.52533294
136NEK20.52524618
137INSRR0.52495168
138BLK0.51946242
139STK100.51914127
140CAMK2D0.50777469
141MAPKAPK20.50366235
142CDK11A0.49583664
143ITK0.49270772
144CDK150.48501356
145CHUK0.48155490
146SYK0.47186765
147ERBB30.47114449
148PRKCZ0.47020061
149MARK20.46666321
150CDK180.46335878
151CSNK2A20.46252689
152LYN0.46087088
153TNIK0.43677020
154CAMK2B0.43560690
155MATK0.43147847
156TGFBR20.42865453
157MAPKAPK50.42772467
158EPHA30.40473114
159GRK60.40271970
160LMTK20.38582871
161TRIM280.37639033
162STK380.35091111
163MINK10.34423607
164PKN10.34142781

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.02227516
2Mismatch repair_Homo sapiens_hsa034303.98685987
3DNA replication_Homo sapiens_hsa030303.64124143
4Proteasome_Homo sapiens_hsa030503.46954549
5Protein export_Homo sapiens_hsa030603.05994416
6RNA polymerase_Homo sapiens_hsa030202.98732453
7Collecting duct acid secretion_Homo sapiens_hsa049662.95716770
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.86469886
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.77488837
10Synaptic vesicle cycle_Homo sapiens_hsa047212.67863215
11Oxidative phosphorylation_Homo sapiens_hsa001902.61438196
12Pyrimidine metabolism_Homo sapiens_hsa002402.58754608
13Parkinsons disease_Homo sapiens_hsa050122.46354156
14Lysosome_Homo sapiens_hsa041422.45555681
15Homologous recombination_Homo sapiens_hsa034402.37465693
16Vibrio cholerae infection_Homo sapiens_hsa051102.22547269
17Spliceosome_Homo sapiens_hsa030402.15369496
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.14940265
19Base excision repair_Homo sapiens_hsa034102.06989008
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.02231728
21Nucleotide excision repair_Homo sapiens_hsa034201.95131465
22Huntingtons disease_Homo sapiens_hsa050161.90800048
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71785245
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70382520
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67523408
26One carbon pool by folate_Homo sapiens_hsa006701.65031862
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.59595517
28Alzheimers disease_Homo sapiens_hsa050101.58328339
29Sulfur relay system_Homo sapiens_hsa041221.56251243
30Sulfur metabolism_Homo sapiens_hsa009201.55272980
31Butanoate metabolism_Homo sapiens_hsa006501.51362872
32RNA degradation_Homo sapiens_hsa030181.43910452
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39042053
34Folate biosynthesis_Homo sapiens_hsa007901.38799346
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38572438
36Purine metabolism_Homo sapiens_hsa002301.33596177
37Glutathione metabolism_Homo sapiens_hsa004801.31795256
38Fanconi anemia pathway_Homo sapiens_hsa034601.31475004
39Vitamin B6 metabolism_Homo sapiens_hsa007501.29042627
40Tryptophan metabolism_Homo sapiens_hsa003801.26743080
41Basal transcription factors_Homo sapiens_hsa030221.25015880
42Non-homologous end-joining_Homo sapiens_hsa034501.22712953
43Other glycan degradation_Homo sapiens_hsa005111.22578462
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.22507787
45RNA transport_Homo sapiens_hsa030131.21814863
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.21377392
47Cell cycle_Homo sapiens_hsa041101.20985039
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20420867
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19153748
50Rheumatoid arthritis_Homo sapiens_hsa053231.14812867
51Selenocompound metabolism_Homo sapiens_hsa004501.10438780
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07936085
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07285706
54Steroid biosynthesis_Homo sapiens_hsa001001.01502491
55Regulation of autophagy_Homo sapiens_hsa041400.98506796
56Phototransduction_Homo sapiens_hsa047440.97703787
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96380614
58Arachidonic acid metabolism_Homo sapiens_hsa005900.96376411
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95376360
60Sphingolipid metabolism_Homo sapiens_hsa006000.94191833
61Ether lipid metabolism_Homo sapiens_hsa005650.92115912
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91724354
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90299028
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87639248
65N-Glycan biosynthesis_Homo sapiens_hsa005100.86720965
66Nicotine addiction_Homo sapiens_hsa050330.83255741
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83129493
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80150209
69Chemical carcinogenesis_Homo sapiens_hsa052040.78732354
70Fatty acid elongation_Homo sapiens_hsa000620.78358113
71Insulin secretion_Homo sapiens_hsa049110.77790581
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77584227
73Galactose metabolism_Homo sapiens_hsa000520.76755369
74p53 signaling pathway_Homo sapiens_hsa041150.71637254
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71031787
76Metabolic pathways_Homo sapiens_hsa011000.70900802
77Linoleic acid metabolism_Homo sapiens_hsa005910.70855325
78Fatty acid metabolism_Homo sapiens_hsa012120.70842299
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69786235
80Epstein-Barr virus infection_Homo sapiens_hsa051690.68452965
81Histidine metabolism_Homo sapiens_hsa003400.68371847
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67999253
83Fructose and mannose metabolism_Homo sapiens_hsa000510.66357595
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.66308205
85Herpes simplex infection_Homo sapiens_hsa051680.65537489
86GABAergic synapse_Homo sapiens_hsa047270.65135655
87Phagosome_Homo sapiens_hsa041450.64956943
88Pentose phosphate pathway_Homo sapiens_hsa000300.64668966
89Peroxisome_Homo sapiens_hsa041460.63816807
90Primary immunodeficiency_Homo sapiens_hsa053400.63558921
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63024698
92Antigen processing and presentation_Homo sapiens_hsa046120.62952134
93Dopaminergic synapse_Homo sapiens_hsa047280.62516741
94Salmonella infection_Homo sapiens_hsa051320.61384666
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59301655
96Salivary secretion_Homo sapiens_hsa049700.58545863
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55572963
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53692119
99Mineral absorption_Homo sapiens_hsa049780.52157561
100Legionellosis_Homo sapiens_hsa051340.50319962
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49895359
102Tyrosine metabolism_Homo sapiens_hsa003500.49855677
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49148309
104Circadian entrainment_Homo sapiens_hsa047130.47894051
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47842465
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47687885
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47414455
108Systemic lupus erythematosus_Homo sapiens_hsa053220.47175559
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46604589
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46349484
111Morphine addiction_Homo sapiens_hsa050320.45730982
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45029992
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44473672
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44135852
115Phenylalanine metabolism_Homo sapiens_hsa003600.39458469
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38731885
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38670984
118Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37500269
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.36890739
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.36577068
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.34961035
122mRNA surveillance pathway_Homo sapiens_hsa030150.34913734
123Carbon metabolism_Homo sapiens_hsa012000.34113163
124Retinol metabolism_Homo sapiens_hsa008300.34030600
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32820194
126Hematopoietic cell lineage_Homo sapiens_hsa046400.32305905
127Fat digestion and absorption_Homo sapiens_hsa049750.30744375
128Biosynthesis of amino acids_Homo sapiens_hsa012300.30190213
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29331480
130Axon guidance_Homo sapiens_hsa043600.29198578
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.28263417
132Pyruvate metabolism_Homo sapiens_hsa006200.26471829
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.26285487
134beta-Alanine metabolism_Homo sapiens_hsa004100.26189396
135Cardiac muscle contraction_Homo sapiens_hsa042600.25490379
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24967840
137Measles_Homo sapiens_hsa051620.24333967
138Graft-versus-host disease_Homo sapiens_hsa053320.23711148
139Fatty acid degradation_Homo sapiens_hsa000710.22044759
140Arginine and proline metabolism_Homo sapiens_hsa003300.19189802
141Thyroid cancer_Homo sapiens_hsa052160.18502173
142Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17950205
143Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16864912

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