NUDT15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)5.65573844
2purine nucleobase biosynthetic process (GO:0009113)5.55354815
3chromatin remodeling at centromere (GO:0031055)4.99308708
4CENP-A containing nucleosome assembly (GO:0034080)4.85389789
5establishment of integrated proviral latency (GO:0075713)4.78108343
6DNA unwinding involved in DNA replication (GO:0006268)4.71632827
7folic acid metabolic process (GO:0046655)4.66771303
8ribosome assembly (GO:0042255)4.15036167
9histone exchange (GO:0043486)4.14081593
10DNA strand elongation involved in DNA replication (GO:0006271)4.08891129
11mitotic metaphase plate congression (GO:0007080)4.07651581
12mitotic nuclear envelope disassembly (GO:0007077)4.02588581
13maturation of SSU-rRNA (GO:0030490)3.97161996
14DNA replication checkpoint (GO:0000076)3.93358900
15somatic hypermutation of immunoglobulin genes (GO:0016446)3.90276186
16somatic diversification of immune receptors via somatic mutation (GO:0002566)3.90276186
17DNA replication-independent nucleosome organization (GO:0034724)3.87128576
18DNA replication-independent nucleosome assembly (GO:0006336)3.87128576
19DNA replication-dependent nucleosome organization (GO:0034723)3.86924747
20DNA replication-dependent nucleosome assembly (GO:0006335)3.86924747
21DNA strand elongation (GO:0022616)3.81556209
22regulation of translational termination (GO:0006449)3.78064126
23membrane disassembly (GO:0030397)3.77601109
24nuclear envelope disassembly (GO:0051081)3.77601109
25establishment of viral latency (GO:0019043)3.70290738
26DNA double-strand break processing (GO:0000729)3.66213143
27DNA damage response, detection of DNA damage (GO:0042769)3.62349823
28folic acid-containing compound biosynthetic process (GO:0009396)3.60569871
29DNA ligation (GO:0006266)3.56408865
30ribosome biogenesis (GO:0042254)3.55624306
31DNA replication initiation (GO:0006270)3.54925189
32metaphase plate congression (GO:0051310)3.54039400
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.51794898
34nuclear pore organization (GO:0006999)3.50960562
35protein localization to chromosome, centromeric region (GO:0071459)3.49515374
36cullin deneddylation (GO:0010388)3.45302865
37mitotic sister chromatid segregation (GO:0000070)3.44357010
38formation of translation preinitiation complex (GO:0001731)3.44233582
39protein localization to kinetochore (GO:0034501)3.40891879
40pre-miRNA processing (GO:0031054)3.40572364
41negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.38816544
42proteasome assembly (GO:0043248)3.37173268
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36486167
44regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.34382698
45regulation of mitotic spindle checkpoint (GO:1903504)3.34382698
46IMP biosynthetic process (GO:0006188)3.34131397
47kinetochore organization (GO:0051383)3.33637295
48anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.31494601
49chaperone-mediated protein transport (GO:0072321)3.30278259
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.29013152
51protein deneddylation (GO:0000338)3.28224537
52sister chromatid segregation (GO:0000819)3.28065763
53DNA catabolic process, exonucleolytic (GO:0000738)3.25823150
54positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.25763314
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.24704669
56mRNA cleavage (GO:0006379)3.24041395
57telomere maintenance via semi-conservative replication (GO:0032201)3.23490209
58regulation of helicase activity (GO:0051095)3.22378801
59mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.22269009
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.18904212
61L-serine metabolic process (GO:0006563)3.18806319
62regulation of mitochondrial translation (GO:0070129)3.17107662
63nuclear envelope organization (GO:0006998)3.16624793
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14615498
65postreplication repair (GO:0006301)3.11572057
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11376219
67IMP metabolic process (GO:0046040)3.11295087
68negative regulation of DNA-dependent DNA replication (GO:2000104)3.11184183
69ribonucleoprotein complex biogenesis (GO:0022613)3.10137481
70regulation of centriole replication (GO:0046599)3.09227474
71kinetochore assembly (GO:0051382)3.08499700
72regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.07139050
73regulation of mitotic metaphase/anaphase transition (GO:0030071)3.07139050
74non-recombinational repair (GO:0000726)3.06511213
75double-strand break repair via nonhomologous end joining (GO:0006303)3.06511213
76rRNA modification (GO:0000154)3.04724280
77replication fork processing (GO:0031297)3.02631107
78negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.02625382
79negative regulation of DNA-templated transcription, elongation (GO:0032785)3.02625382
80rRNA processing (GO:0006364)3.01550521
81peptidyl-arginine omega-N-methylation (GO:0035247)2.99903736
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.99108887
83telomere maintenance via telomere lengthening (GO:0010833)2.99050065
84nucleotide-excision repair, DNA gap filling (GO:0006297)2.97760598
85DNA strand renaturation (GO:0000733)2.97564313
86rRNA metabolic process (GO:0016072)2.96255714
87heterochromatin organization (GO:0070828)2.96097169
88regulation of cellular amino acid metabolic process (GO:0006521)2.95601586
89regulation of mitotic sister chromatid separation (GO:0010965)2.95527388
90regulation of mitotic sister chromatid segregation (GO:0033047)2.95527388
91regulation of sister chromatid segregation (GO:0033045)2.95527388
92protein neddylation (GO:0045116)2.95137780
93regulation of translation in response to stress (GO:0043555)2.94498501
94nuclear pore complex assembly (GO:0051292)2.94317729
95negative regulation of ligase activity (GO:0051352)2.94100994
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94100994
97negative regulation of RNA splicing (GO:0033119)2.93180451
98negative regulation of mRNA processing (GO:0050686)2.92497343
99regulation of spindle organization (GO:0090224)2.92398731
100mitotic spindle assembly checkpoint (GO:0007094)2.92292257
101negative regulation of chromosome segregation (GO:0051985)2.91376782
102negative regulation of sister chromatid segregation (GO:0033046)2.89306680
103negative regulation of mitotic sister chromatid separation (GO:2000816)2.89306680
104negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89306680
105negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89306680
106signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89262074
107signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89262074
108signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89262074
109ribosomal large subunit biogenesis (GO:0042273)2.89191432
110regulation of ubiquitin-protein transferase activity (GO:0051438)2.89090427
111translesion synthesis (GO:0019985)2.88809588
112negative regulation of translational initiation (GO:0045947)2.87907497
113methionine biosynthetic process (GO:0009086)2.87236240
114DNA duplex unwinding (GO:0032508)2.86934599
115DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.85437333
116RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.84992635
117tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.84992635
118negative regulation of DNA recombination (GO:0045910)2.84559281
119establishment of chromosome localization (GO:0051303)2.83788279
120peptidyl-histidine modification (GO:0018202)2.83071235
121cell cycle G1/S phase transition (GO:0044843)2.82816705
122G1/S transition of mitotic cell cycle (GO:0000082)2.82816705
123spliceosomal snRNP assembly (GO:0000387)2.82746365
124transcription elongation from RNA polymerase III promoter (GO:0006385)2.82510731
125termination of RNA polymerase III transcription (GO:0006386)2.82510731
126negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.82143152
127regulation of chromosome segregation (GO:0051983)2.81718099
128spindle assembly checkpoint (GO:0071173)2.81710100
129DNA geometric change (GO:0032392)2.81316648
130telomere maintenance via recombination (GO:0000722)2.81014375
131positive regulation of cell cycle checkpoint (GO:1901978)2.80836871
132mitotic recombination (GO:0006312)2.79493283
133positive regulation of ligase activity (GO:0051351)2.79032526
134mitotic spindle checkpoint (GO:0071174)2.76296356
135regulation of centrosome cycle (GO:0046605)2.75763344
136mitotic G1/S transition checkpoint (GO:0044819)2.74196511
137transcription elongation from RNA polymerase I promoter (GO:0006362)2.73920571
138attachment of spindle microtubules to kinetochore (GO:0008608)2.73465404
139pseudouridine synthesis (GO:0001522)2.73064506
140spindle checkpoint (GO:0031577)2.72199761
141folic acid-containing compound metabolic process (GO:0006760)2.72181250
142positive regulation of chromosome segregation (GO:0051984)2.70206270
143S-adenosylmethionine metabolic process (GO:0046500)2.69270033
144signal transduction involved in cell cycle checkpoint (GO:0072395)2.68684194
145signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.67919856
146intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.67919856
147histone H2A monoubiquitination (GO:0035518)2.66605851
148signal transduction involved in DNA integrity checkpoint (GO:0072401)2.66288781
149signal transduction involved in DNA damage checkpoint (GO:0072422)2.66288781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.98168986
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.94941425
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.76573991
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.70638017
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33067433
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.19684525
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.12054363
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.09484455
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.06520870
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.95013441
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.94256663
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85112810
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.81780955
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72792028
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71828135
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53034551
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50147264
18XRN2_22483619_ChIP-Seq_HELA_Human2.45336464
19VDR_23849224_ChIP-Seq_CD4+_Human2.45274836
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36856636
21DCP1A_22483619_ChIP-Seq_HELA_Human2.24535155
22MYC_22102868_ChIP-Seq_BL_Human2.21262432
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19635886
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.19583441
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16670495
26CIITA_25753668_ChIP-Seq_RAJI_Human2.11487826
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.07438325
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06733266
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05467018
30FOXP3_21729870_ChIP-Seq_TREG_Human2.05263665
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.05253295
32* GABP_19822575_ChIP-Seq_HepG2_Human1.98362462
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96371272
34AR_21909140_ChIP-Seq_LNCAP_Human1.95250435
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95039612
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94175951
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86151676
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84464539
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80028642
40TTF2_22483619_ChIP-Seq_HELA_Human1.79596755
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72274801
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69721503
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.67695052
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64767781
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60947492
46KDM5A_27292631_Chip-Seq_BREAST_Human1.60792381
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57960375
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57821976
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55298416
50* NOTCH1_21737748_ChIP-Seq_TLL_Human1.53035744
51NANOG_16153702_ChIP-ChIP_HESCs_Human1.51779010
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49961113
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48816285
54ELK1_19687146_ChIP-ChIP_HELA_Human1.48759277
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48187176
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.47655841
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41501936
58EWS_26573619_Chip-Seq_HEK293_Human1.41466492
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.38230299
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36132792
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34923260
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33408558
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31438255
64SOX2_16153702_ChIP-ChIP_HESCs_Human1.30841800
65* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29843177
66ZNF263_19887448_ChIP-Seq_K562_Human1.29821642
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29467302
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29129741
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28578209
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28303008
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27911228
72* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.27701800
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27008597
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26519224
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26297707
76ZNF274_21170338_ChIP-Seq_K562_Hela1.26273774
77TFEB_21752829_ChIP-Seq_HELA_Human1.24928868
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23334623
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21895649
80VDR_21846776_ChIP-Seq_THP-1_Human1.18269110
81* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18197543
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17253351
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15991752
84FUS_26573619_Chip-Seq_HEK293_Human1.15306663
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14732467
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14519471
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13635218
88* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12833791
89VDR_22108803_ChIP-Seq_LS180_Human1.11943981
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05362098
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04366301
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04321588
93FLI1_27457419_Chip-Seq_LIVER_Mouse1.01190784
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00631605
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00352126
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99211646
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98247371
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98137932
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98137932
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98137932
101TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97663566
102SOX17_20123909_ChIP-Seq_XEN_Mouse0.97436397
103IRF1_19129219_ChIP-ChIP_H3396_Human0.94964344
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93361372
105MYC_18940864_ChIP-ChIP_HL60_Human0.86627799
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85201843
107STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84702693
108IGF1R_20145208_ChIP-Seq_DFB_Human0.83636637
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82712368
110UTX_26944678_Chip-Seq_JUKART_Human0.82187975
111* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81961046
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81089454
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80198280
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79801561
115* SPI1_23547873_ChIP-Seq_NB4_Human0.79591847
116NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.77179919
117ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.76054110
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75282647
119ELK1_22589737_ChIP-Seq_MCF10A_Human0.75207484
120MYB_26560356_Chip-Seq_TH2_Human0.74213180
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74032005
122TP63_19390658_ChIP-ChIP_HaCaT_Human0.73507411
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.71960439
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.71731739
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71447012
126MAF_26560356_Chip-Seq_TH2_Human0.71062416
127SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.70418958
128PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70309171
129TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.69915495
130MYB_21317192_ChIP-Seq_ERMYB_Mouse0.69833772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.77916164
2MP0003111_abnormal_nucleus_morphology4.30552267
3MP0010094_abnormal_chromosome_stability4.29570615
4MP0008057_abnormal_DNA_replication4.22150653
5MP0004957_abnormal_blastocyst_morpholog3.79559308
6MP0003077_abnormal_cell_cycle3.68480115
7MP0008058_abnormal_DNA_repair2.95979005
8MP0003941_abnormal_skin_development2.69133487
9MP0008877_abnormal_DNA_methylation2.64494138
10MP0003123_paternal_imprinting2.54117596
11MP0001730_embryonic_growth_arrest2.51310578
12MP0006292_abnormal_olfactory_placode2.47122432
13MP0009697_abnormal_copulation2.40496710
14MP0002396_abnormal_hematopoietic_system2.25063484
15MP0008932_abnormal_embryonic_tissue2.22491766
16MP0001293_anophthalmia2.18108056
17MP0010352_gastrointestinal_tract_polyps2.09737635
18MP0002938_white_spotting2.03062885
19MP0009333_abnormal_splenocyte_physiolog1.97187577
20MP0000350_abnormal_cell_proliferation1.93959012
21MP0003984_embryonic_growth_retardation1.91913391
22MP0002088_abnormal_embryonic_growth/wei1.85381603
23MP0001672_abnormal_embryogenesis/_devel1.81477354
24MP0005380_embryogenesis_phenotype1.81477354
25MP0001697_abnormal_embryo_size1.81283751
26MP0006036_abnormal_mitochondrial_physio1.80275566
27MP0002398_abnormal_bone_marrow1.79744475
28MP0010030_abnormal_orbit_morphology1.79555804
29MP0008007_abnormal_cellular_replicative1.78923938
30MP0001529_abnormal_vocalization1.77608141
31MP0003786_premature_aging1.77345479
32MP0006035_abnormal_mitochondrial_morpho1.76954497
33MP0003937_abnormal_limbs/digits/tail_de1.75914069
34MP0003806_abnormal_nucleotide_metabolis1.71486905
35MP0003646_muscle_fatigue1.69535188
36MP0003136_yellow_coat_color1.67452114
37MP0000703_abnormal_thymus_morphology1.65602443
38MP0002080_prenatal_lethality1.65127821
39MP0000689_abnormal_spleen_morphology1.64268384
40MP0002722_abnormal_immune_system1.61437171
41MP0004808_abnormal_hematopoietic_stem1.60835246
42MP0003718_maternal_effect1.57174255
43MP0002254_reproductive_system_inflammat1.55057731
44MP0003763_abnormal_thymus_physiology1.54357588
45MP0003221_abnormal_cardiomyocyte_apopto1.53729814
46MP0006072_abnormal_retinal_apoptosis1.52481811
47MP0001800_abnormal_humoral_immune1.51766304
48MP0003119_abnormal_digestive_system1.51212563
49MP0000358_abnormal_cell_content/1.43871705
50MP0010307_abnormal_tumor_latency1.41696494
51MP0004133_heterotaxia1.41112438
52MP0003186_abnormal_redox_activity1.40896890
53MP0008789_abnormal_olfactory_epithelium1.39514273
54MP0002429_abnormal_blood_cell1.36409945
55MP0000716_abnormal_immune_system1.36212142
56MP0002019_abnormal_tumor_incidence1.34667078
57MP0001727_abnormal_embryo_implantation1.31856476
58MP0003183_abnormal_peptide_metabolism1.31711293
59MP0000313_abnormal_cell_death1.31690529
60MP0004233_abnormal_muscle_weight1.29143087
61MP0004185_abnormal_adipocyte_glucose1.28927188
62MP0002269_muscular_atrophy1.27057682
63MP0009672_abnormal_birth_weight1.26483114
64MP0002086_abnormal_extraembryonic_tissu1.25548312
65MP0001286_abnormal_eye_development1.25035387
66MP0002697_abnormal_eye_size1.22759735
67MP0001188_hyperpigmentation1.22122089
68MP0002234_abnormal_pharynx_morphology1.19490855
69MP0002085_abnormal_embryonic_tissue1.18342162
70MP0000747_muscle_weakness1.18289811
71MP0002233_abnormal_nose_morphology1.16994033
72MP0000490_abnormal_crypts_of1.16384211
73MP0004197_abnormal_fetal_growth/weight/1.16362695
74MP0003121_genomic_imprinting1.16167851
75MP0005499_abnormal_olfactory_system1.15042725
76MP0005394_taste/olfaction_phenotype1.15042725
77MP0003656_abnormal_erythrocyte_physiolo1.14634634
78MP0002420_abnormal_adaptive_immunity1.11339745
79MP0004147_increased_porphyrin_level1.09599718
80MP0002452_abnormal_antigen_presenting1.08733604
81MP0002822_catalepsy1.08447027
82MP0001819_abnormal_immune_cell1.08424875
83MP0005384_cellular_phenotype1.08326677
84MP0003315_abnormal_perineum_morphology1.06993842
85MP0002111_abnormal_tail_morphology1.06309684
86MP0005666_abnormal_adipose_tissue1.06022028
87MP0002084_abnormal_developmental_patter1.05783673
88MP0003122_maternal_imprinting1.05658596
89MP0000372_irregular_coat_pigmentation1.05562759
90MP0002210_abnormal_sex_determination1.03429291
91MP0002723_abnormal_immune_serum1.03042186
92MP0008995_early_reproductive_senescence1.01531140
93MP0000537_abnormal_urethra_morphology1.01429884
94MP0005621_abnormal_cell_physiology1.00821799
95MP0002751_abnormal_autonomic_nervous1.00701111
96MP0005076_abnormal_cell_differentiation0.99324030
97MP0001929_abnormal_gametogenesis0.98947682
98MP0000049_abnormal_middle_ear0.98498264
99MP0003890_abnormal_embryonic-extraembry0.97121008
100MP0000647_abnormal_sebaceous_gland0.96533997
101MP0005451_abnormal_body_composition0.93020929
102MP0001661_extended_life_span0.92666030
103MP0001145_abnormal_male_reproductive0.92091279
104MP0002160_abnormal_reproductive_system0.91291261
105MP0002163_abnormal_gland_morphology0.89056506
106MP0009840_abnormal_foam_cell0.87815285
107MP0005670_abnormal_white_adipose0.86297494
108MP0003567_abnormal_fetal_cardiomyocyte0.84201420
109MP0005671_abnormal_response_to0.82681207
110MP0003303_peritoneal_inflammation0.81001810
111MP0000750_abnormal_muscle_regeneration0.80857167
112MP0001835_abnormal_antigen_presentation0.80825016
113MP0004084_abnormal_cardiac_muscle0.78030799
114MP0002090_abnormal_vision0.77692991
115MP0003755_abnormal_palate_morphology0.75464335
116MP0005084_abnormal_gallbladder_morpholo0.74412641
117MP0004130_abnormal_muscle_cell0.74230034
118MP0000685_abnormal_immune_system0.73372334
119MP0009703_decreased_birth_body0.73339898
120MP0002970_abnormal_white_adipose0.73179808
121MP0008770_decreased_survivor_rate0.72215591
122MP0001119_abnormal_female_reproductive0.70954946
123MP0005391_vision/eye_phenotype0.70940724
124MP0000579_abnormal_nail_morphology0.70867058
125MP0003861_abnormal_nervous_system0.70540771
126MP0000609_abnormal_liver_physiology0.70365029
127MP0004215_abnormal_myocardial_fiber0.69482138
128MP0000653_abnormal_sex_gland0.69207685
129MP0001485_abnormal_pinna_reflex0.68839123
130MP0000013_abnormal_adipose_tissue0.67669288
131MP0002092_abnormal_eye_morphology0.67667102
132MP0002736_abnormal_nociception_after0.66775694
133MP0005253_abnormal_eye_physiology0.65102679
134MP0001873_stomach_inflammation0.64522296
135MP0003698_abnormal_male_reproductive0.64004633
136MP0005395_other_phenotype0.62886960
137MP0000631_abnormal_neuroendocrine_gland0.62642257
138MP0005375_adipose_tissue_phenotype0.62187666
139MP0001853_heart_inflammation0.61744502
140MP0002102_abnormal_ear_morphology0.60755311
141MP0000465_gastrointestinal_hemorrhage0.60643100
142MP0005000_abnormal_immune_tolerance0.60076879
143MP0005387_immune_system_phenotype0.59934092
144MP0001790_abnormal_immune_system0.59934092
145MP0000428_abnormal_craniofacial_morphol0.59285838
146MP0001299_abnormal_eye_distance/0.59171754
147MP0005187_abnormal_penis_morphology0.58882139
148MP0001545_abnormal_hematopoietic_system0.58874871
149MP0005397_hematopoietic_system_phenotyp0.58874871
150MP0001177_atelectasis0.58439245
151MP0005367_renal/urinary_system_phenotyp0.58359185
152MP0000516_abnormal_urinary_system0.58359185
153MP0001984_abnormal_olfaction0.58211100
154MP0002106_abnormal_muscle_physiology0.56803075

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.22247140
2Birth length less than 3rd percentile (HP:0003561)4.08472256
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.95167074
4Carpal bone hypoplasia (HP:0001498)3.86333096
5Breast hypoplasia (HP:0003187)3.64796608
6Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.63400693
7Cerebral hypomyelination (HP:0006808)3.60317272
8Agnosia (HP:0010524)3.59163561
9Chromsome breakage (HP:0040012)3.58882714
10Irregular epiphyses (HP:0010582)3.51440790
11Meckel diverticulum (HP:0002245)3.35637942
12Hypoplasia of the capital femoral epiphysis (HP:0003090)3.20259025
13Abnormality of the ileum (HP:0001549)3.16904572
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.02569065
15Abnormality of chromosome stability (HP:0003220)2.96173122
16Small epiphyses (HP:0010585)2.95579641
17Abnormal lung lobation (HP:0002101)2.94835092
18Pancreatic islet-cell hyperplasia (HP:0004510)2.92838014
19Increased hepatocellular lipid droplets (HP:0006565)2.90466703
20Absent epiphyses (HP:0010577)2.89785402
21Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.89785402
22Abnormality of the preputium (HP:0100587)2.86502859
23IgM deficiency (HP:0002850)2.82412288
24Abnormality of the lower motor neuron (HP:0002366)2.66337274
25Progressive macrocephaly (HP:0004481)2.63534597
26Reticulocytopenia (HP:0001896)2.60687106
27Duodenal stenosis (HP:0100867)2.57913565
28Small intestinal stenosis (HP:0012848)2.57913565
29Lipid accumulation in hepatocytes (HP:0006561)2.56981469
30Shoulder girdle muscle weakness (HP:0003547)2.55985834
31Multiple enchondromatosis (HP:0005701)2.55614236
32Abnormality of the pancreatic islet cells (HP:0006476)2.50533757
33Abnormality of endocrine pancreas physiology (HP:0012093)2.50533757
34Hypoglycemic coma (HP:0001325)2.49348164
35Microvesicular hepatic steatosis (HP:0001414)2.49104176
36Cerebral edema (HP:0002181)2.48641872
37Hyperglycinemia (HP:0002154)2.48210759
38Abnormal mitochondria in muscle tissue (HP:0008316)2.47303237
39Patellar aplasia (HP:0006443)2.46772141
40Glossoptosis (HP:0000162)2.45212707
41Flattened epiphyses (HP:0003071)2.44598951
42Toxemia of pregnancy (HP:0100603)2.43967527
43Medulloblastoma (HP:0002885)2.40090463
44Abnormality of the duodenum (HP:0002246)2.35619950
45CNS hypomyelination (HP:0003429)2.35520348
46Abnormality of the astrocytes (HP:0100707)2.32109457
47Astrocytoma (HP:0009592)2.32109457
48Abnormality of serum amino acid levels (HP:0003112)2.32096130
49Abnormality of methionine metabolism (HP:0010901)2.31696702
50Absent radius (HP:0003974)2.30099718
51Neoplasm of the rectum (HP:0100743)2.29925163
52Nephroblastoma (Wilms tumor) (HP:0002667)2.28902862
53Aplasia/Hypoplasia of the patella (HP:0006498)2.27521248
54T lymphocytopenia (HP:0005403)2.26205428
55Cortical dysplasia (HP:0002539)2.26125087
56Horseshoe kidney (HP:0000085)2.26012003
57Acute necrotizing encephalopathy (HP:0006965)2.24682729
58Upper motor neuron abnormality (HP:0002127)2.24288871
59Areflexia of lower limbs (HP:0002522)2.23533231
60Methylmalonic acidemia (HP:0002912)2.22521250
61Embryonal renal neoplasm (HP:0011794)2.21343251
62Absent forearm bone (HP:0003953)2.20536856
63Aplasia involving forearm bones (HP:0009822)2.20536856
64Basal cell carcinoma (HP:0002671)2.20407833
65Rough bone trabeculation (HP:0100670)2.19205185
66Pelvic girdle muscle weakness (HP:0003749)2.19158773
67Rhabdomyosarcoma (HP:0002859)2.15405694
68Triphalangeal thumb (HP:0001199)2.14458540
69Type I transferrin isoform profile (HP:0003642)2.14059181
70Abnormality of cells of the erythroid lineage (HP:0012130)2.13640810
71Abnormality of serine family amino acid metabolism (HP:0010894)2.11743493
72Abnormality of glycine metabolism (HP:0010895)2.11743493
73Sloping forehead (HP:0000340)2.11591326
74Septo-optic dysplasia (HP:0100842)2.11436525
75Recurrent viral infections (HP:0004429)2.09079379
76Neoplasm of the small intestine (HP:0100833)2.06728576
77Neoplasm of the colon (HP:0100273)2.06315658
78Lactic acidosis (HP:0003128)2.06095340
79Hyperglycinuria (HP:0003108)2.05873470
80Angiofibromas (HP:0010615)2.05165506
81Adenoma sebaceum (HP:0009720)2.05165506
82Neoplasm of the adrenal gland (HP:0100631)2.04532233
83Hepatic necrosis (HP:0002605)2.04492048
84Increased CSF lactate (HP:0002490)2.03320472
85Chronic otitis media (HP:0000389)2.02099027
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01841850
87Abnormality of alanine metabolism (HP:0010916)2.01841850
88Hyperalaninemia (HP:0003348)2.01841850
89Microretrognathia (HP:0000308)2.00770537
90Abnormality of glycolysis (HP:0004366)2.00710958
91Increased serum pyruvate (HP:0003542)2.00710958
92Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98919202
93Colon cancer (HP:0003003)1.98814775
94Postnatal microcephaly (HP:0005484)1.97265014
95Irregular vertebral endplates (HP:0003301)1.97018438
96Hepatocellular necrosis (HP:0001404)1.96398430
97Hypoplasia of the pons (HP:0012110)1.96359898
98Abnormality of T cell number (HP:0011839)1.95570299
99Methylmalonic aciduria (HP:0012120)1.95472973
100Ectopic kidney (HP:0000086)1.95349656
101Megaloblastic anemia (HP:0001889)1.95000361
102IgG deficiency (HP:0004315)1.94444073
103Increased serum lactate (HP:0002151)1.94112632
104Hypoplastic pelvis (HP:0008839)1.93610151
105Amaurosis fugax (HP:0100576)1.93153587
106Abnormality of the pons (HP:0007361)1.92652961
107Stenosis of the external auditory canal (HP:0000402)1.91869305
108Abnormality of the calcaneus (HP:0008364)1.91818773
109Abnormality of T cells (HP:0002843)1.91605909
110Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90875253
111Neoplasm of the pancreas (HP:0002894)1.90844172
112Absent thumb (HP:0009777)1.89545196
113Acute encephalopathy (HP:0006846)1.89245064
114CNS demyelination (HP:0007305)1.88343057
115Panhypogammaglobulinemia (HP:0003139)1.87752015
116Abnormality of the labia minora (HP:0012880)1.87213171
117Abnormality of the hip-girdle musculature (HP:0001445)1.87133745
118Abnormality of the musculature of the pelvis (HP:0001469)1.87133745
119Rhabdomyolysis (HP:0003201)1.86988973
120Abnormality of homocysteine metabolism (HP:0010919)1.86882941
121Homocystinuria (HP:0002156)1.86882941
122Abnormality of the carotid arteries (HP:0005344)1.85744874
123Recurrent bronchitis (HP:0002837)1.84160442
124Degeneration of anterior horn cells (HP:0002398)1.83812798
125Abnormality of the anterior horn cell (HP:0006802)1.83812798
126Abnormal glycosylation (HP:0012345)1.83531020
127Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83531020
128Abnormal protein N-linked glycosylation (HP:0012347)1.83531020
129Abnormal protein glycosylation (HP:0012346)1.83531020
130Reduced antithrombin III activity (HP:0001976)1.83131661
131Exercise intolerance (HP:0003546)1.82420096
132Progressive muscle weakness (HP:0003323)1.82057778
133Emotional lability (HP:0000712)1.81825548
134Cafe-au-lait spot (HP:0000957)1.81142163
135Bilateral microphthalmos (HP:0007633)1.80105729
136Glioma (HP:0009733)1.79867534
137Biliary tract neoplasm (HP:0100574)1.79783327
138Supernumerary spleens (HP:0009799)1.79293363
139Renal Fanconi syndrome (HP:0001994)1.77738049
140Papilloma (HP:0012740)1.77406427
141Verrucae (HP:0200043)1.77406427
142Impulsivity (HP:0100710)1.76730109
143Abnormality of chromosome segregation (HP:0002916)1.76655705
144Myelodysplasia (HP:0002863)1.76046488
145Increased nuchal translucency (HP:0010880)1.75976132
146Leukodystrophy (HP:0002415)1.75697384
147Neoplasm of striated muscle (HP:0009728)1.75610267
148Macrocytic anemia (HP:0001972)1.75568977
149Facial hemangioma (HP:0000329)1.75518169
150Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75125263
151Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75125263
152Clubbing of toes (HP:0100760)1.74593082
153Mitochondrial inheritance (HP:0001427)1.74485308
154Cellular immunodeficiency (HP:0005374)1.73297963
155Absent septum pellucidum (HP:0001331)1.73297623
156Entropion (HP:0000621)1.73093700
157Abnormality of abdominal situs (HP:0011620)1.70682502
158Abdominal situs inversus (HP:0003363)1.70682502
159Agammaglobulinemia (HP:0004432)1.70665998
160Urinary urgency (HP:0000012)1.70569800
161Pancytopenia (HP:0001876)1.70529023
162Metaphyseal cupping (HP:0003021)1.70495915
163Facial cleft (HP:0002006)1.68679264
164Cleft eyelid (HP:0000625)1.67052554
165Duplicated collecting system (HP:0000081)1.66436041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.11404802
2WEE13.96307478
3CDC73.84728357
4EIF2AK13.59987618
5TSSK63.53390668
6VRK23.30360311
7WNK33.20192655
8MAP4K12.72920291
9PBK2.66339127
10MKNK22.44133231
11BRSK22.39995153
12SRPK12.33472584
13TRIM282.29608167
14NEK22.22993266
15STK162.06976378
16CDK122.04419128
17GRK62.03783184
18EIF2AK32.03588908
19PDK42.03174276
20PDK32.03174276
21NUAK12.01735338
22NME21.89237165
23STK101.85896888
24TAF11.83384889
25NEK11.78193633
26MAP3K101.69618042
27CCNB11.67835779
28BRSK11.65376664
29PLK11.59491928
30SCYL21.59080753
31DYRK31.58551027
32BMPR1B1.55066081
33TESK21.43645372
34MAP3K81.42899497
35TTK1.40793099
36EEF2K1.39460435
37LRRK21.25505289
38STK31.22027373
39ATR1.17557629
40PASK1.16674880
41TLK11.15229599
42TNIK1.12014347
43CHEK11.11245000
44PLK31.11139850
45CSNK1G11.09993114
46NME11.08496024
47BCKDK1.05982251
48TYK21.05458144
49CDK41.03502689
50EIF2AK21.02432591
51AURKB1.01301199
52PDK20.99046300
53ALK0.96246846
54RPS6KB20.94382305
55TAOK10.93619808
56MKNK10.93441650
57CSNK1G30.93194150
58RPS6KA40.92915297
59VRK10.90692429
60ERBB40.88152485
61CDK70.87738408
62PNCK0.86374095
63EPHA20.85916210
64CSNK1G20.84982951
65PAK40.84638170
66AKT30.84264734
67DYRK20.84121735
68MAP3K120.82447111
69PKN20.82069539
70PLK20.80684193
71ERBB30.79055398
72ITK0.75484900
73PIM10.74939311
74STK240.74673082
75CDK190.74402530
76STK38L0.72692715
77STK40.72468069
78MAP4K20.71894432
79LATS10.71139439
80ACVR1B0.70999730
81CDK20.70634509
82CSF1R0.69661885
83TRIB30.69545116
84MAP2K30.69468083
85PLK40.69049252
86CSNK1A1L0.68956889
87MELK0.67370701
88CAMKK20.64369993
89TTN0.63371143
90BRD40.62801334
91MTOR0.61979795
92CLK10.61256647
93CHEK20.59115639
94ATM0.58581452
95AURKA0.57646962
96BRAF0.57514977
97BTK0.56334793
98OXSR10.56039353
99INSRR0.55731442
100ZAP700.55388198
101CDK10.55138501
102FGFR10.53790020
103SYK0.50763450
104MARK30.50591322
105CSNK2A20.49707414
106KSR10.46548575
107GRK10.44423274
108MAPKAPK50.44034992
109MAP3K110.43163977
110DAPK10.43044550
111PRKCI0.42839040
112MAP3K30.41457531
113TXK0.40544767
114FLT30.40363864
115STK390.39936874
116MINK10.39734669
117PAK10.38060375
118MAP3K40.37623022
119WNK40.37337225
120CDK80.33521583
121PRKCG0.33024879
122RIPK40.32360234
123TIE10.30569784
124LIMK10.29928428
125RPS6KA50.29847285
126TGFBR10.29370867
127CDK30.28836044
128MST40.28723968
129PRKDC0.28441334
130TBK10.28008876
131LCK0.27044895
132CDK180.26404221
133CDK140.25254926
134BCR0.25004018
135MAP2K70.24607707
136CSNK2A10.24085012
137CSNK1E0.23794379
138RAF10.22134862
139LYN0.20937178
140RPS6KA60.20162182
141ZAK0.18405399
142CSNK1D0.16963275
143RPS6KC10.16162273
144RPS6KL10.16162273

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.02914390
2DNA replication_Homo sapiens_hsa030304.02796206
3Mismatch repair_Homo sapiens_hsa034304.02210981
4Proteasome_Homo sapiens_hsa030503.62178126
5RNA polymerase_Homo sapiens_hsa030203.37395025
6RNA transport_Homo sapiens_hsa030133.20756720
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.17275381
8Spliceosome_Homo sapiens_hsa030403.01149363
9Cell cycle_Homo sapiens_hsa041102.56950081
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52060850
11Base excision repair_Homo sapiens_hsa034102.51250977
12Ribosome_Homo sapiens_hsa030102.38675727
13One carbon pool by folate_Homo sapiens_hsa006702.37263381
14Nucleotide excision repair_Homo sapiens_hsa034202.32433072
15Pyrimidine metabolism_Homo sapiens_hsa002402.17646377
16Vitamin B6 metabolism_Homo sapiens_hsa007502.17145369
17Homologous recombination_Homo sapiens_hsa034402.09186552
18RNA degradation_Homo sapiens_hsa030181.67668939
19Non-homologous end-joining_Homo sapiens_hsa034501.57569328
20Primary immunodeficiency_Homo sapiens_hsa053401.56613426
21Antigen processing and presentation_Homo sapiens_hsa046121.55682134
22Epstein-Barr virus infection_Homo sapiens_hsa051691.50715714
23Steroid biosynthesis_Homo sapiens_hsa001001.50453736
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49638215
25Carbon metabolism_Homo sapiens_hsa012001.49577377
26Fanconi anemia pathway_Homo sapiens_hsa034601.48071527
27mRNA surveillance pathway_Homo sapiens_hsa030151.41212792
28Pentose phosphate pathway_Homo sapiens_hsa000301.36981568
29Basal transcription factors_Homo sapiens_hsa030221.36666707
30Biosynthesis of amino acids_Homo sapiens_hsa012301.33147276
31Oocyte meiosis_Homo sapiens_hsa041141.26937745
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26809967
33Parkinsons disease_Homo sapiens_hsa050121.21480652
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21450118
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21075195
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17336607
37p53 signaling pathway_Homo sapiens_hsa041151.09860382
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.09683561
39Purine metabolism_Homo sapiens_hsa002301.07415435
40Glutathione metabolism_Homo sapiens_hsa004801.07139571
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07113027
42Viral carcinogenesis_Homo sapiens_hsa052031.02238373
43Legionellosis_Homo sapiens_hsa051340.98185935
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96733640
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95848362
46Selenocompound metabolism_Homo sapiens_hsa004500.93469588
47Oxidative phosphorylation_Homo sapiens_hsa001900.88908585
48Huntingtons disease_Homo sapiens_hsa050160.87507595
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83304252
50B cell receptor signaling pathway_Homo sapiens_hsa046620.79794127
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79726756
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78412672
53Pyruvate metabolism_Homo sapiens_hsa006200.75017901
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.72792261
55Systemic lupus erythematosus_Homo sapiens_hsa053220.71754410
56Herpes simplex infection_Homo sapiens_hsa051680.70711205
57T cell receptor signaling pathway_Homo sapiens_hsa046600.68436126
58mTOR signaling pathway_Homo sapiens_hsa041500.67662195
59Sulfur metabolism_Homo sapiens_hsa009200.65251941
60HTLV-I infection_Homo sapiens_hsa051660.64989829
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62953319
62Arginine and proline metabolism_Homo sapiens_hsa003300.61169378
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59377761
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58727137
65Fatty acid elongation_Homo sapiens_hsa000620.58300265
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.56159848
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54408592
68Basal cell carcinoma_Homo sapiens_hsa052170.51839441
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51693102
70Caffeine metabolism_Homo sapiens_hsa002320.51126410
71Peroxisome_Homo sapiens_hsa041460.50435792
72N-Glycan biosynthesis_Homo sapiens_hsa005100.50388247
73Vitamin digestion and absorption_Homo sapiens_hsa049770.50338563
74Colorectal cancer_Homo sapiens_hsa052100.49164260
75Hippo signaling pathway_Homo sapiens_hsa043900.48077131
76TGF-beta signaling pathway_Homo sapiens_hsa043500.45338880
77Alzheimers disease_Homo sapiens_hsa050100.45095623
78FoxO signaling pathway_Homo sapiens_hsa040680.43922942
79Fatty acid degradation_Homo sapiens_hsa000710.42436494
80Phototransduction_Homo sapiens_hsa047440.41671436
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41590852
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41005151
83Hedgehog signaling pathway_Homo sapiens_hsa043400.39808567
84Apoptosis_Homo sapiens_hsa042100.39321340
85Regulation of autophagy_Homo sapiens_hsa041400.37716975
86Fatty acid metabolism_Homo sapiens_hsa012120.37386968
87Folate biosynthesis_Homo sapiens_hsa007900.37136909
88HIF-1 signaling pathway_Homo sapiens_hsa040660.36890593
89Insulin signaling pathway_Homo sapiens_hsa049100.36812020
90Tryptophan metabolism_Homo sapiens_hsa003800.36212093
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35160111
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34448311
93Propanoate metabolism_Homo sapiens_hsa006400.34342626
94Wnt signaling pathway_Homo sapiens_hsa043100.34220963
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33113318
96beta-Alanine metabolism_Homo sapiens_hsa004100.32999303
97Measles_Homo sapiens_hsa051620.32900120
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32109087
99Acute myeloid leukemia_Homo sapiens_hsa052210.31763684
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30887138
101Hepatitis B_Homo sapiens_hsa051610.30775326
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30436019
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28533259
104Lysine degradation_Homo sapiens_hsa003100.28011068
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27545709
106MicroRNAs in cancer_Homo sapiens_hsa052060.27328989
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26858977
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26698226
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25986428
110Metabolic pathways_Homo sapiens_hsa011000.25596794
111Protein export_Homo sapiens_hsa030600.24964045
112Insulin resistance_Homo sapiens_hsa049310.24807722
113AMPK signaling pathway_Homo sapiens_hsa041520.24172415
114Chronic myeloid leukemia_Homo sapiens_hsa052200.23704501
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.23626778
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23540612
117Cardiac muscle contraction_Homo sapiens_hsa042600.23034297
118Retinol metabolism_Homo sapiens_hsa008300.22028448
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.20315902
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19970211
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19257492
122Sulfur relay system_Homo sapiens_hsa041220.19042110
123Renal cell carcinoma_Homo sapiens_hsa052110.18305706
124Galactose metabolism_Homo sapiens_hsa000520.17882246
125Thyroid cancer_Homo sapiens_hsa052160.17600034
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.16767350
127Fat digestion and absorption_Homo sapiens_hsa049750.16575527
128Viral myocarditis_Homo sapiens_hsa054160.16408505
129Chemical carcinogenesis_Homo sapiens_hsa052040.15735537
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.15714030
131Shigellosis_Homo sapiens_hsa051310.15570774
132Hematopoietic cell lineage_Homo sapiens_hsa046400.15372924
133Tyrosine metabolism_Homo sapiens_hsa003500.15296713
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14565519
135Nitrogen metabolism_Homo sapiens_hsa009100.14559495
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14409392
137Butanoate metabolism_Homo sapiens_hsa006500.14408842

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