NUDT16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)4.86254382
2doxorubicin metabolic process (GO:0044598)4.86254382
3daunorubicin metabolic process (GO:0044597)4.86254382
4respiratory chain complex IV assembly (GO:0008535)4.83754703
5cytochrome complex assembly (GO:0017004)4.10359110
6regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.97988519
7presynaptic membrane assembly (GO:0097105)3.94527833
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88573294
9platelet dense granule organization (GO:0060155)3.78084533
10regulation of T cell mediated cytotoxicity (GO:0001914)3.67681653
11positive regulation of T cell mediated cytotoxicity (GO:0001916)3.66813847
12lymphoid progenitor cell differentiation (GO:0002320)3.62093864
13superoxide anion generation (GO:0042554)3.60940663
14response to interferon-beta (GO:0035456)3.57225311
15ribosomal small subunit assembly (GO:0000028)3.43531246
16presynaptic membrane organization (GO:0097090)3.35999239
17defense response to protozoan (GO:0042832)3.28289040
18neutrophil activation involved in immune response (GO:0002283)3.26370031
19mature B cell differentiation involved in immune response (GO:0002313)3.26176356
20GPI anchor biosynthetic process (GO:0006506)3.21273166
21cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18629666
22protein localization to endosome (GO:0036010)3.15819868
23mature B cell differentiation (GO:0002335)3.15166013
24preassembly of GPI anchor in ER membrane (GO:0016254)3.10710720
25sodium ion export (GO:0071436)3.10484956
26detection of bacterium (GO:0016045)3.09881771
27NADH metabolic process (GO:0006734)3.06782671
28alpha-linolenic acid metabolic process (GO:0036109)3.03469792
29epoxygenase P450 pathway (GO:0019373)3.02911390
30detection of molecule of bacterial origin (GO:0032490)3.02550372
31lymph node development (GO:0048535)3.00574894
32definitive hemopoiesis (GO:0060216)2.99238348
33detection of other organism (GO:0098543)2.98749516
34mannosylation (GO:0097502)2.97342671
35mast cell activation (GO:0045576)2.97248323
36GPI anchor metabolic process (GO:0006505)2.96674753
37ethanol oxidation (GO:0006069)2.95892649
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.94835508
39complement activation, alternative pathway (GO:0006957)2.92168930
40regulation of activation of Janus kinase activity (GO:0010533)2.90093105
41regulation of ARF protein signal transduction (GO:0032012)2.88977824
42type I interferon signaling pathway (GO:0060337)2.87255631
43cellular response to type I interferon (GO:0071357)2.87255631
44adhesion of symbiont to host (GO:0044406)2.85433713
45aminoglycoside antibiotic metabolic process (GO:0030647)2.85164887
46response to type I interferon (GO:0034340)2.84810260
47cell communication by electrical coupling (GO:0010644)2.83771777
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81689567
49response to protozoan (GO:0001562)2.81193590
50cellular response to interferon-beta (GO:0035458)2.78254399
51creatine metabolic process (GO:0006600)2.72522456
52regulation of B cell receptor signaling pathway (GO:0050855)2.71958811
53negative regulation of T cell mediated immunity (GO:0002710)2.71403077
54positive regulation of defense response to virus by host (GO:0002230)2.70752424
55detection of external biotic stimulus (GO:0098581)2.68740632
56negative regulation of dendrite morphogenesis (GO:0050774)2.68556672
57signal peptide processing (GO:0006465)2.67692640
58axon ensheathment in central nervous system (GO:0032291)2.67517915
59central nervous system myelination (GO:0022010)2.67517915
60cellular potassium ion homeostasis (GO:0030007)2.67299508
61positive regulation of gamma-delta T cell activation (GO:0046645)2.66800017
62adenosine metabolic process (GO:0046085)2.66774586
63negative regulation of osteoblast proliferation (GO:0033689)2.66621571
64positive regulation of receptor recycling (GO:0001921)2.66132126
65interferon-gamma production (GO:0032609)2.64277382
66urea metabolic process (GO:0019627)2.64052211
67postsynaptic membrane organization (GO:0001941)2.61753532
68protein complex biogenesis (GO:0070271)2.61247294
69regulation of antigen processing and presentation (GO:0002577)2.59523799
70cytoskeletal anchoring at plasma membrane (GO:0007016)2.59144048
71L-fucose catabolic process (GO:0042355)2.59136880
72fucose catabolic process (GO:0019317)2.59136880
73L-fucose metabolic process (GO:0042354)2.59136880
74C-terminal protein lipidation (GO:0006501)2.58776836
75CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.58178470
76myeloid dendritic cell activation (GO:0001773)2.56651407
77regulation of pigment cell differentiation (GO:0050932)2.56503350
78barbed-end actin filament capping (GO:0051016)2.55954544
79response to peptidoglycan (GO:0032494)2.55804566
80macrophage activation involved in immune response (GO:0002281)2.54952028
81cellular response to exogenous dsRNA (GO:0071360)2.54427427
82positive regulation of antigen processing and presentation (GO:0002579)2.52214117
83intracellular pH reduction (GO:0051452)2.51841328
84neutrophil activation (GO:0042119)2.51540813
85leukocyte aggregation (GO:0070486)2.51434739
86urea cycle (GO:0000050)2.51009709
87cellular response to monoamine stimulus (GO:0071868)2.50730307
88cellular response to catecholamine stimulus (GO:0071870)2.50730307
89modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.49985642
90positive regulation by organism of defense response of other organism involved in symbiotic interact2.49985642
91modulation by symbiont of host immune response (GO:0052553)2.49985642
92positive regulation by symbiont of host defense response (GO:0052509)2.49985642
93modulation by symbiont of host defense response (GO:0052031)2.49985642
94modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.49985642
95nitrogen cycle metabolic process (GO:0071941)2.49542410
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.49173625
97negative regulation of T-helper cell differentiation (GO:0045623)2.49173625
98regulation of metalloenzyme activity (GO:0048552)2.48690674
99negative regulation of fibrinolysis (GO:0051918)2.47799134
100regulation of T cell mediated immunity (GO:0002709)2.47316073
101negative regulation of execution phase of apoptosis (GO:1900118)2.46840153
102angiotensin maturation (GO:0002003)2.46816782
103positive regulation of interleukin-17 production (GO:0032740)2.44515103
104positive regulation of cellular amine metabolic process (GO:0033240)2.44370482
105megakaryocyte development (GO:0035855)2.43402586
106regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.43365992
107regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.43188732
108activation of protein kinase A activity (GO:0034199)2.43072808
109negative regulation of erythrocyte differentiation (GO:0045647)2.43065882
110DNA deamination (GO:0045006)2.42862015
111T cell lineage commitment (GO:0002360)2.42510333
112regulation of T-helper 1 cell differentiation (GO:0045625)2.41788911
113fucosylation (GO:0036065)2.41143741
114cortical actin cytoskeleton organization (GO:0030866)2.41070402
115response to mercury ion (GO:0046689)2.40889236
116fructose metabolic process (GO:0006000)2.40265615
117negative regulation of myeloid cell apoptotic process (GO:0033033)2.40234095
118negative regulation of viral entry into host cell (GO:0046597)2.39676274
119respiratory burst (GO:0045730)2.39578275
120stress fiber assembly (GO:0043149)2.38672030
121cellular response to epinephrine stimulus (GO:0071872)2.37450908
122regulation of synaptic vesicle exocytosis (GO:2000300)2.37296961
123response to interferon-alpha (GO:0035455)2.36957456
124positive regulation of interleukin-1 beta secretion (GO:0050718)2.36817526
125ethanol metabolic process (GO:0006067)2.36571731
126detection of biotic stimulus (GO:0009595)2.35473287
127nucleotide transmembrane transport (GO:1901679)2.35248137
128adhesion of symbiont to host cell (GO:0044650)2.34772783
129virion attachment to host cell (GO:0019062)2.34772783
130low-density lipoprotein particle clearance (GO:0034383)2.33642462
131negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.32610739
132negative regulation of cell killing (GO:0031342)2.32610739
133negative regulation of fatty acid transport (GO:2000192)2.31957739
134centriole assembly (GO:0098534)2.31923528
135positive regulation of cellular amide metabolic process (GO:0034250)2.31718319
136cellular response to interleukin-15 (GO:0071350)2.30783228
137negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.30608988
138C-terminal protein amino acid modification (GO:0018410)2.30274490
139peptide catabolic process (GO:0043171)2.30217040
140negative regulation of viral genome replication (GO:0045071)2.30187054
141lipoprotein transport (GO:0042953)2.29989142
142T cell homeostasis (GO:0043029)2.29642716
143positive regulation of macrophage cytokine production (GO:0060907)2.29209653
144regulation of T cell receptor signaling pathway (GO:0050856)2.29093926
145secretory granule organization (GO:0033363)2.27929306
146energy homeostasis (GO:0097009)2.27634592
147negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.27481238
148regulation of relaxation of muscle (GO:1901077)2.27202773
149superoxide metabolic process (GO:0006801)2.27185789
150positive regulation of macrophage differentiation (GO:0045651)2.26592789
151hormone catabolic process (GO:0042447)2.26199226
152tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.25856789
153RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.25856789
154positive regulation of T cell migration (GO:2000406)2.25419213
155positive regulation of T-helper 1 type immune response (GO:0002827)2.25347890
156regulation of protein activation cascade (GO:2000257)2.24956031
157regulation of glucose import in response to insulin stimulus (GO:2001273)2.22877766
158positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.20395610
159cell-cell junction maintenance (GO:0045217)2.19425214
160regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.19125929
161regulation of complement activation (GO:0030449)2.18521528
162L-amino acid import (GO:0043092)2.18421413
163neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.17665662
164actin filament polymerization (GO:0030041)2.15375818
165positive regulation of Rap GTPase activity (GO:0032854)2.14720443
166synaptic vesicle docking involved in exocytosis (GO:0016081)2.13520039
167cardiac muscle contraction (GO:0060048)2.13074206
168positive regulation of lipid catabolic process (GO:0050996)2.12960696
169cortical cytoskeleton organization (GO:0030865)2.11484906
170regulation of early endosome to late endosome transport (GO:2000641)2.10889077
171negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.10055833
172regulation of fibrinolysis (GO:0051917)2.05815614
173mannose metabolic process (GO:0006013)2.05108617
174oxaloacetate metabolic process (GO:0006107)2.04821340
175regulation of macrophage cytokine production (GO:0010935)2.04783967
176response to monoamine (GO:0071867)2.04085065
177response to catecholamine (GO:0071869)2.04085065
178exogenous drug catabolic process (GO:0042738)2.03691943
179cerebellar granule cell differentiation (GO:0021707)2.03385891
180regulation of cholesterol homeostasis (GO:2000188)2.02222113
181diacylglycerol metabolic process (GO:0046339)2.02023761
182fat-soluble vitamin biosynthetic process (GO:0042362)2.02010959
183cell communication involved in cardiac conduction (GO:0086065)2.01397490
184omega-hydroxylase P450 pathway (GO:0097267)2.00157544
185cardiac myofibril assembly (GO:0055003)1.99391814
186positive regulation of triglyceride lipase activity (GO:0061365)1.99064804
187positive regulation of lipoprotein lipase activity (GO:0051006)1.99064804
188amyloid precursor protein catabolic process (GO:0042987)1.98302596
189negative regulation of potassium ion transmembrane transporter activity (GO:1901017)1.98217743
190endocytic recycling (GO:0032456)1.97591132
191modification by symbiont of host morphology or physiology (GO:0044003)1.96913502
192embryonic retina morphogenesis in camera-type eye (GO:0060059)1.96157739
193sarcoplasmic reticulum calcium ion transport (GO:0070296)1.94483173
194cell junction maintenance (GO:0034331)1.94190813
195glycosphingolipid catabolic process (GO:0046479)1.94160519

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.18737448
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.15929399
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.11355823
4GBX2_23144817_ChIP-Seq_PC3_Human3.11073927
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.10062794
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.85531851
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.75199023
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.72884269
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.55547260
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.46723916
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43555800
12LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.42342445
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37057956
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.35643183
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.27717669
16SCL_19346495_ChIP-Seq_HPC-7_Human2.26661161
17IGF1R_20145208_ChIP-Seq_DFB_Human2.26429618
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23874781
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.19437259
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.15036662
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.13334182
22LXR_22292898_ChIP-Seq_THP-1_Human2.12950817
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09926957
24CLOCK_20551151_ChIP-Seq_293T_Human2.06952870
25ESR2_21235772_ChIP-Seq_MCF-7_Human2.05829424
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.98852817
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96732469
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93994597
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.93695769
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92972377
31KDM2B_26808549_Chip-Seq_K562_Human1.89561838
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89498663
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89420209
34TAF15_26573619_Chip-Seq_HEK293_Human1.89242278
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.89058074
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.87667425
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85589306
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83534104
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.80704857
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76335781
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75851031
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75292481
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73439460
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.69578812
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69479626
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.69361684
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69324578
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69082494
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67787475
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65623313
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64985997
52SUZ12_18555785_Chip-Seq_ESCs_Mouse1.64421002
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.63115132
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.61596202
55KDM2B_26808549_Chip-Seq_DND41_Human1.61189583
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60874313
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60656388
58DROSHA_22980978_ChIP-Seq_HELA_Human1.60049311
59VDR_21846776_ChIP-Seq_THP-1_Human1.59546672
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59493913
61P53_22387025_ChIP-Seq_ESCs_Mouse1.58821209
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.58383504
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57789589
64TCF7_22412390_ChIP-Seq_EML_Mouse1.57108045
65RACK7_27058665_Chip-Seq_MCF-7_Human1.53744823
66EZH2_22144423_ChIP-Seq_EOC_Human1.51642722
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.51348119
68RUNX1_27457419_Chip-Seq_LIVER_Mouse1.51163565
69SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50823976
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.49834161
71P300_18555785_Chip-Seq_ESCs_Mouse1.49421948
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.48328771
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47845716
74NMYC_18555785_Chip-Seq_ESCs_Mouse1.47311556
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46446133
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46009675
77VDR_22108803_ChIP-Seq_LS180_Human1.44264688
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.43389053
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.42789024
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.42222448
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41704975
82EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.41107251
83P300_19829295_ChIP-Seq_ESCs_Human1.40827336
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.40557896
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40279338
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.39117315
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39067016
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38581193
89RUNX_20019798_ChIP-Seq_JUKART_Human1.37363735
90TBX20_22080862_ChIP-Seq_HEART_Mouse1.37219513
91TBX20_22328084_ChIP-Seq_HEART_Mouse1.37219513
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.36206468
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.35243516
94GATA1_22025678_ChIP-Seq_K562_Human1.33900479
95SMAD1_18555785_Chip-Seq_ESCs_Mouse1.32794982
96OCT4_18555785_Chip-Seq_ESCs_Mouse1.32150144
97SPI1_23547873_ChIP-Seq_NB4_Human1.31650399
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.31501800
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31413382
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31283469
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31233081
102ER_23166858_ChIP-Seq_MCF-7_Human1.31132809
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.30021514
104PU1_27457419_Chip-Seq_LIVER_Mouse1.28688083
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28022587
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26327998
107ZFX_18555785_Chip-Seq_ESCs_Mouse1.26145573
108SOX2_18555785_Chip-Seq_ESCs_Mouse1.25367137
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25195404
110GATA1_19941827_ChIP-Seq_MEL_Mouse1.25006985
111VDR_24763502_ChIP-Seq_THP-1_Human1.24502904
112KDM2B_26808549_Chip-Seq_JURKAT_Human1.23070020
113RARB_27405468_Chip-Seq_BRAIN_Mouse1.21987509
114SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.21619111
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21243528
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20747052
117FUS_26573619_Chip-Seq_HEK293_Human1.20321436
118CTCF_18555785_Chip-Seq_ESCs_Mouse1.19355451
119OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19324275
120KLF4_18555785_Chip-Seq_ESCs_Mouse1.18696008
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18435608
122ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17903422
123EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17208686
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16509506
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16243374
126ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16193953
127ESRRB_18555785_Chip-Seq_ESCs_Mouse1.15717819
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14003947
129TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13833436
130ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13721265
131P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13430517
132SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13317174
133STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12220120
134HTT_18923047_ChIP-ChIP_STHdh_Human1.11387563
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10612839
136FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10582141
137SMC4_20622854_ChIP-Seq_HELA_Human1.09762109
138* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09707710
139* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09070174
140HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09058768
141ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08976288
142FOXA2_19822575_ChIP-Seq_HepG2_Human1.08703623
143KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08590454
144SPI1_23127762_ChIP-Seq_K562_Human1.08569671
145JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08448711
146PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07698743
147TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06554287
148TP63_17297297_ChIP-ChIP_HaCaT_Human1.05531305
149KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05096938
150CREB1_26743006_Chip-Seq_LNCaP_Human1.04921644
151IRF1_19129219_ChIP-ChIP_H3396_Human1.04351892
152SRF_21415370_ChIP-Seq_HL-1_Mouse1.04316955
153MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04277825
154KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03601290
155EWS_26573619_Chip-Seq_HEK293_Human1.03183997
156MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03149931
157NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02800928
158CBX2_27304074_Chip-Seq_ESCs_Mouse1.02581303
159EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02574561
160NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02517652
161KDM2B_26808549_Chip-Seq_REH_Human1.01836483
162PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01651338
163LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01276989
164STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01236274
165RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01132535
166CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00289538
167RNF2_27304074_Chip-Seq_NSC_Mouse0.99987266
168SMAD_19615063_ChIP-ChIP_OVARY_Human0.99514313
169GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99233195
170SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99116133
171RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99032949
172GATA2_21666600_ChIP-Seq_HMVEC_Human0.98690608
173TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97702922
174EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97352091
175RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97352091
176CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97016152
177* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96701534
178EP300_21415370_ChIP-Seq_HL-1_Mouse0.96629476
179SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96126188
180TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95197178
181MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94537197
182CTCF_27219007_Chip-Seq_Bcells_Human0.94450900
183TET1_21490601_ChIP-Seq_MESCs_Mouse0.91456766
184CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91070689
185ESR1_21235772_ChIP-Seq_MCF-7_Human0.89844935
186SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88147724
187SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87992860
188ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87947822
189CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86400721
190CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86299725
191SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85581241
192SA1_27219007_Chip-Seq_ERYTHROID_Human0.85409174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.30877930
2MP0005409_darkened_coat_color3.30273636
3MP0001188_hyperpigmentation3.15674133
4MP0001835_abnormal_antigen_presentation3.13605068
5MP0003705_abnormal_hypodermis_morpholog2.94720742
6MP0009785_altered_susceptibility_to2.70216317
7MP0002876_abnormal_thyroid_physiology2.69068909
8MP0005671_abnormal_response_to2.67272897
9MP0009697_abnormal_copulation2.64044976
10MP0004858_abnormal_nervous_system2.62243611
11MP0009379_abnormal_foot_pigmentation2.59357349
12MP0003690_abnormal_glial_cell2.59084198
13MP0004859_abnormal_synaptic_plasticity2.56759335
14MP0004147_increased_porphyrin_level2.53805813
15MP0002148_abnormal_hypersensitivity_rea2.51675857
16MP0003724_increased_susceptibility_to2.49709975
17MP0005174_abnormal_tail_pigmentation2.46776990
18MP0003303_peritoneal_inflammation2.46566207
19MP0005365_abnormal_bile_salt2.43162398
20MP0003329_amyloid_beta_deposits2.43091094
21MP0003183_abnormal_peptide_metabolism2.42709877
22MP0001986_abnormal_taste_sensitivity2.36928895
23MP0000015_abnormal_ear_pigmentation2.33529372
24MP0005360_urolithiasis2.31708032
25MP0003191_abnormal_cellular_cholesterol2.10121670
26MP0005025_abnormal_response_to2.09005135
27MP0002396_abnormal_hematopoietic_system2.08525009
28MP0005085_abnormal_gallbladder_physiolo2.05010485
29MP0004270_analgesia2.04274045
30MP0009840_abnormal_foam_cell2.02135732
31MP0000685_abnormal_immune_system1.99005116
32MP0001790_abnormal_immune_system1.98919492
33MP0005387_immune_system_phenotype1.98919492
34MP0005075_abnormal_melanosome_morpholog1.98391046
35MP0004130_abnormal_muscle_cell1.98376700
36MP0005000_abnormal_immune_tolerance1.98340660
37MP0002723_abnormal_immune_serum1.95690973
38MP0003879_abnormal_hair_cell1.95003118
39MP0000751_myopathy1.93484323
40MP0006292_abnormal_olfactory_placode1.93114909
41MP0004381_abnormal_hair_follicle1.92841510
42MP0002419_abnormal_innate_immunity1.91526523
43MP0003763_abnormal_thymus_physiology1.90305887
44MP0000372_irregular_coat_pigmentation1.90236178
45MP0001800_abnormal_humoral_immune1.89208613
46MP0001905_abnormal_dopamine_level1.82527956
47MP0002420_abnormal_adaptive_immunity1.82391492
48MP0002452_abnormal_antigen_presenting1.82019344
49MP0001819_abnormal_immune_cell1.80862359
50MP0000604_amyloidosis1.70543246
51MP0003136_yellow_coat_color1.69424022
52MP0005666_abnormal_adipose_tissue1.69241394
53MP0003868_abnormal_feces_composition1.68507514
54MP0005171_absent_coat_pigmentation1.68109441
55MP0002971_abnormal_brown_adipose1.65767860
56MP0005670_abnormal_white_adipose1.65566466
57MP0001958_emphysema1.62802707
58MP0003075_altered_response_to1.61171962
59MP0002095_abnormal_skin_pigmentation1.60889080
60MP0003828_pulmonary_edema1.60191667
61MP0003091_abnormal_cell_migration1.57597759
62MP0000465_gastrointestinal_hemorrhage1.56944022
63MP0003300_gastrointestinal_ulcer1.56090522
64MP0005464_abnormal_platelet_physiology1.55080102
65MP0008004_abnormal_stomach_pH1.54312523
66MP0003880_abnormal_central_pattern1.53815819
67MP0003172_abnormal_lysosome_physiology1.50778080
68MP0005451_abnormal_body_composition1.49919400
69MP0003436_decreased_susceptibility_to1.47966448
70MP0001348_abnormal_lacrimal_gland1.46070070
71MP0001529_abnormal_vocalization1.44708445
72MP0002132_abnormal_respiratory_system1.41463410
73MP0006082_CNS_inflammation1.40491354
74MP0000716_abnormal_immune_system1.40315097
75MP0005645_abnormal_hypothalamus_physiol1.38843565
76MP0002166_altered_tumor_susceptibility1.38290925
77MP0008260_abnormal_autophagy1.36370345
78MP0001873_stomach_inflammation1.36244425
79MP0010329_abnormal_lipoprotein_level1.36013093
80MP0002398_abnormal_bone_marrow1.34627278
81MP0000747_muscle_weakness1.33046737
82MP0005166_decreased_susceptibility_to1.32685567
83MP0004142_abnormal_muscle_tone1.28156962
84MP0002102_abnormal_ear_morphology1.27822910
85MP0003566_abnormal_cell_adhesion1.27622780
86MP0002933_joint_inflammation1.27604240
87MP0002332_abnormal_exercise_endurance1.26972351
88MP0004087_abnormal_muscle_fiber1.24815417
89MP0005646_abnormal_pituitary_gland1.23814185
90MP0000920_abnormal_myelination1.20796784
91MP0001851_eye_inflammation1.18097296
92MP0010155_abnormal_intestine_physiology1.16897256
93MP0002006_tumorigenesis1.16434587
94MP0006138_congestive_heart_failure1.16010483
95MP0000681_abnormal_thyroid_gland1.14360135
96MP0004185_abnormal_adipocyte_glucose1.14344492
97MP0000689_abnormal_spleen_morphology1.13679224
98MP0010630_abnormal_cardiac_muscle1.13414967
99MP0002277_abnormal_respiratory_mucosa1.11682852
100MP0005310_abnormal_salivary_gland1.10642407
101MP0002118_abnormal_lipid_homeostasis1.10617317
102MP0001533_abnormal_skeleton_physiology1.08740772
103MP0001666_abnormal_nutrient_absorption1.08242589
104MP0003634_abnormal_glial_cell1.07280317
105MP0009115_abnormal_fat_cell1.06551503
106MP0003866_abnormal_defecation1.06510174
107MP0002429_abnormal_blood_cell1.06020180
108MP0003011_delayed_dark_adaptation1.04635825
109MP0002909_abnormal_adrenal_gland1.04176502
110MP0001845_abnormal_inflammatory_respons1.03651135
111MP0005076_abnormal_cell_differentiation1.03516657
112MP0005375_adipose_tissue_phenotype1.03089769
113MP0004742_abnormal_vestibular_system1.02722449
114MP0002089_abnormal_postnatal_growth/wei1.02316791
115MP0005379_endocrine/exocrine_gland_phen1.02044190
116MP0004036_abnormal_muscle_relaxation1.02019239
117MP0002735_abnormal_chemical_nociception1.01434434
118MP0004233_abnormal_muscle_weight1.01193695
119MP0000490_abnormal_crypts_of1.00562633
120MP0008874_decreased_physiological_sensi0.98926795
121MP0004883_abnormal_blood_vessel0.98595791
122MP0002896_abnormal_bone_mineralization0.98526589
123MP0009764_decreased_sensitivity_to0.97723277
124MP0009333_abnormal_splenocyte_physiolog0.95140921
125MP0002722_abnormal_immune_system0.95082305
126MP0002972_abnormal_cardiac_muscle0.95037142
127MP0002638_abnormal_pupillary_reflex0.94632316
128MP0005535_abnormal_body_temperature0.94604638
129MP0002405_respiratory_system_inflammati0.93162885
130MP0005334_abnormal_fat_pad0.93131159
131MP0008469_abnormal_protein_level0.91497484
132MP0005084_abnormal_gallbladder_morpholo0.91275763
133MP0005248_abnormal_Harderian_gland0.91032064
134MP0008875_abnormal_xenobiotic_pharmacok0.90596893
135MP0008569_lethality_at_weaning0.90391958
136MP0001849_ear_inflammation0.90367069
137MP0001984_abnormal_olfaction0.89219148
138MP0004484_altered_response_of0.89131165
139MP0004084_abnormal_cardiac_muscle0.88613564
140MP0001502_abnormal_circadian_rhythm0.88464587
141MP0000750_abnormal_muscle_regeneration0.87741601
142MP0003279_aneurysm0.86957321
143MP0001486_abnormal_startle_reflex0.86765625
144MP0003635_abnormal_synaptic_transmissio0.85708237
145MP0010234_abnormal_vibrissa_follicle0.85471313
146MP0005397_hematopoietic_system_phenotyp0.84433191
147MP0001545_abnormal_hematopoietic_system0.84433191
148MP0004019_abnormal_vitamin_homeostasis0.83765442
149MP0001663_abnormal_digestive_system0.82139187
150MP0000749_muscle_degeneration0.81835584
151MP0002736_abnormal_nociception_after0.81567842
152MP0000759_abnormal_skeletal_muscle0.80982974
153MP0002063_abnormal_learning/memory/cond0.80426146
154MP0009780_abnormal_chondrocyte_physiolo0.79789804
155MP0002009_preneoplasia0.78809999
156MP0005330_cardiomyopathy0.78044175
157MP0002272_abnormal_nervous_system0.77922356
158MP0001440_abnormal_grooming_behavior0.77200983
159MP0010368_abnormal_lymphatic_system0.77150940
160MP0006276_abnormal_autonomic_nervous0.77022049
161MP0002064_seizures0.76729883
162MP0000609_abnormal_liver_physiology0.76572145
163MP0005584_abnormal_enzyme/coenzyme_acti0.76561033
164MP0001968_abnormal_touch/_nociception0.76383485
165MP0001501_abnormal_sleep_pattern0.74691753
166MP0005388_respiratory_system_phenotype0.74197351
167MP0002133_abnormal_respiratory_system0.74197351
168MP0000858_altered_metastatic_potential0.73973332
169MP0005164_abnormal_response_to0.73909764
170MP0005423_abnormal_somatic_nervous0.73681476
171MP0001853_heart_inflammation0.73366492
172MP0002249_abnormal_larynx_morphology0.72761848
173MP0005165_increased_susceptibility_to0.72353368
174MP0005319_abnormal_enzyme/_coenzyme0.72074990
175MP0000678_abnormal_parathyroid_gland0.72043363
176MP0004510_myositis0.71711590
177MP0005058_abnormal_lysosome_morphology0.71361005
178MP0003186_abnormal_redox_activity0.71018314
179MP0002067_abnormal_sensory_capabilities0.70636468
180MP0002269_muscular_atrophy0.69974102
181MP0003453_abnormal_keratinocyte_physiol0.69953361
182MP0010386_abnormal_urinary_bladder0.69546317
183MP0001664_abnormal_digestion0.67972581
184MP0001963_abnormal_hearing_physiology0.67168940
185MP0000703_abnormal_thymus_morphology0.65054323
186MP0002998_abnormal_bone_remodeling0.64783279

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)4.29340679
2Systemic lupus erythematosus (HP:0002725)3.97505389
3Complement deficiency (HP:0004431)3.78878449
4Abnormality of complement system (HP:0005339)3.47527601
5Recurrent abscess formation (HP:0002722)3.39112256
6Type I transferrin isoform profile (HP:0003642)3.32212689
7Patchy hypopigmentation of hair (HP:0011365)3.29562057
8Reduced antithrombin III activity (HP:0001976)3.25881820
9Aplastic anemia (HP:0001915)3.19741705
10Deep venous thrombosis (HP:0002625)3.16459004
11Neurofibrillary tangles (HP:0002185)3.15783410
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.13956423
13IgM deficiency (HP:0002850)3.08558467
14White forelock (HP:0002211)3.06871407
15Nonprogressive disorder (HP:0003680)3.02843746
16Type 2 muscle fiber atrophy (HP:0003554)3.02681685
17Elevated erythrocyte sedimentation rate (HP:0003565)2.99015063
18Recurrent bacterial skin infections (HP:0005406)2.98872636
19Bundle branch block (HP:0011710)2.97522761
20Increased hepatocellular lipid droplets (HP:0006565)2.96508439
21Myositis (HP:0100614)2.93200694
22Amyloidosis (HP:0011034)2.91564797
23Renal Fanconi syndrome (HP:0001994)2.87744107
24Obstructive sleep apnea (HP:0002870)2.82730735
25Thyroiditis (HP:0100646)2.82651050
26Abnormality of macrophages (HP:0004311)2.78297245
273-Methylglutaconic aciduria (HP:0003535)2.73938551
28Asymmetric septal hypertrophy (HP:0001670)2.72553148
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.71464498
30Abnormal protein N-linked glycosylation (HP:0012347)2.71464498
31Abnormal protein glycosylation (HP:0012346)2.71464498
32Abnormal glycosylation (HP:0012345)2.71464498
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.68892003
34Glomerulonephritis (HP:0000099)2.65622528
35Protrusio acetabuli (HP:0003179)2.63811128
36Muscle fiber atrophy (HP:0100295)2.63789742
37Cerebral inclusion bodies (HP:0100314)2.62985027
38Difficulty running (HP:0009046)2.58446456
39Centrally nucleated skeletal muscle fibers (HP:0003687)2.56654419
40Lipid accumulation in hepatocytes (HP:0006561)2.56122105
41Exertional dyspnea (HP:0002875)2.53821614
42Meningitis (HP:0001287)2.53482024
43Cerebral aneurysm (HP:0004944)2.52290131
44Petechiae (HP:0000967)2.50939952
45Recurrent skin infections (HP:0001581)2.48259229
46Chronic diarrhea (HP:0002028)2.47319777
47Increased variability in muscle fiber diameter (HP:0003557)2.45066356
48Retrobulbar optic neuritis (HP:0100654)2.44606293
49Optic neuritis (HP:0100653)2.44606293
50Thyroid-stimulating hormone excess (HP:0002925)2.42252003
51Recurrent fungal infections (HP:0002841)2.40537445
52Recurrent pneumonia (HP:0006532)2.40386729
53Distal lower limb muscle weakness (HP:0009053)2.40331918
54Chronic mucocutaneous candidiasis (HP:0002728)2.38717686
55Recurrent cutaneous fungal infections (HP:0011370)2.38717686
56Thrombocytosis (HP:0001894)2.37510038
57Eczematoid dermatitis (HP:0000976)2.37502338
58Mitochondrial inheritance (HP:0001427)2.36883040
59Obstructive lung disease (HP:0006536)2.36470253
60Chronic obstructive pulmonary disease (HP:0006510)2.36470253
61Ankle clonus (HP:0011448)2.36113803
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34226385
63Type 1 muscle fiber predominance (HP:0003803)2.32633762
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.32516794
65Hyporeflexia of lower limbs (HP:0002600)2.31958230
66Sudden death (HP:0001699)2.31704416
67Abnormality of B cell number (HP:0010975)2.29120360
68B lymphocytopenia (HP:0010976)2.29120360
69Congenital sensorineural hearing impairment (HP:0008527)2.28512824
70Vasculitis (HP:0002633)2.28431564
71Prolonged bleeding time (HP:0003010)2.28408572
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28358675
73Abnormality of skeletal muscle fiber size (HP:0012084)2.26186773
74Chromsome breakage (HP:0040012)2.24898690
75Hepatocellular necrosis (HP:0001404)2.24840699
76Stomatitis (HP:0010280)2.24472361
77Vacuolated lymphocytes (HP:0001922)2.23060112
78Heart block (HP:0012722)2.22588582
79Panhypogammaglobulinemia (HP:0003139)2.21001678
80Abnormal atrioventricular conduction (HP:0005150)2.20779269
81Chronic otitis media (HP:0000389)2.20350370
82Atrioventricular block (HP:0001678)2.19698236
83Peritonitis (HP:0002586)2.17917617
84Hemorrhage of the eye (HP:0011885)2.17343709
85Supranuclear gaze palsy (HP:0000605)2.16786807
86Abnormality of the prostate (HP:0008775)2.13642297
87Pancytopenia (HP:0001876)2.12570412
88Purpura (HP:0000979)2.12149982
89Abnormal delayed hypersensitivity skin test (HP:0002963)2.11725182
90Muscle fiber splitting (HP:0003555)2.11523984
91IgG deficiency (HP:0004315)2.11125525
92Agammaglobulinemia (HP:0004432)2.08765386
93Mediastinal lymphadenopathy (HP:0100721)2.07396036
94Severe combined immunodeficiency (HP:0004430)2.05895095
95Aneurysm (HP:0002617)2.05051040
96Vascular tortuosity (HP:0004948)2.04963465
97Hepatic necrosis (HP:0002605)2.03047386
98Febrile seizures (HP:0002373)2.02603711
99Medial flaring of the eyebrow (HP:0010747)2.02081343
100Increased intramyocellular lipid droplets (HP:0012240)2.01871235
101Exercise-induced myalgia (HP:0003738)2.01778651
102Abnormality of T cell physiology (HP:0011840)2.00668976
103Respiratory difficulties (HP:0002880)2.00066128
104Gingivitis (HP:0000230)1.99996672
105Recurrent viral infections (HP:0004429)1.99703836
106Orchitis (HP:0100796)1.98275560
107Abnormality of renal resorption (HP:0011038)1.97207059
108Recurrent sinusitis (HP:0011108)1.96346573
109Foot dorsiflexor weakness (HP:0009027)1.96104989
110Gastrointestinal stroma tumor (HP:0100723)1.95949849
111Neuronal loss in central nervous system (HP:0002529)1.94556370
112Nephritis (HP:0000123)1.93861651
113Increased connective tissue (HP:0009025)1.93447920
114Subaortic stenosis (HP:0001682)1.92860202
115Abnormality of the left ventricular outflow tract (HP:0011103)1.92860202
116Arterial tortuosity (HP:0005116)1.91289035
117Decreased central vision (HP:0007663)1.91247973
118Renal cortical cysts (HP:0000803)1.90967253
119Increased CSF lactate (HP:0002490)1.90890196
120Reticulocytopenia (HP:0001896)1.90095894
121Recurrent lower respiratory tract infections (HP:0002783)1.88612859
122Acute necrotizing encephalopathy (HP:0006965)1.87848446
123Mitral stenosis (HP:0001718)1.87611496
124Albinism (HP:0001022)1.87291490
125Dysostosis multiplex (HP:0000943)1.87001733
126Onion bulb formation (HP:0003383)1.86151885
127Prolonged neonatal jaundice (HP:0006579)1.86052108
128Hypoproteinemia (HP:0003075)1.85708734
129Abnormality of the foot musculature (HP:0001436)1.85474386
130Segmental peripheral demyelination/remyelination (HP:0003481)1.85403303
131Prostate neoplasm (HP:0100787)1.84784535
132Joint hemorrhage (HP:0005261)1.84685136
133Epistaxis (HP:0000421)1.84045888
134Gingival bleeding (HP:0000225)1.83725574
135Weak cry (HP:0001612)1.83459582
136Distal lower limb amyotrophy (HP:0008944)1.83041976
137Polygenic inheritance (HP:0010982)1.82793302
138Xanthomatosis (HP:0000991)1.82739335
139Abnormal rod and cone electroretinograms (HP:0008323)1.82362638
140Ventricular tachycardia (HP:0004756)1.82178529
141Lower limb amyotrophy (HP:0007210)1.80304884
142Neutropenia (HP:0001875)1.80100822
143Severe visual impairment (HP:0001141)1.80025313
144Recurrent gram-negative bacterial infections (HP:0005420)1.78689663
145Abnormality of T cells (HP:0002843)1.78457823
146Abnormality of the Achilles tendon (HP:0005109)1.77760868
147Growth hormone excess (HP:0000845)1.77094671
148Ventricular fibrillation (HP:0001663)1.76845007
149Spontaneous hematomas (HP:0007420)1.76636540
150Microvesicular hepatic steatosis (HP:0001414)1.75612089
151Abnormality of cells of the erythroid lineage (HP:0012130)1.75287481
152Neonatal hypoglycemia (HP:0001998)1.74746930
153Apathy (HP:0000741)1.74709948
154Action tremor (HP:0002345)1.74658902
155Encephalitis (HP:0002383)1.74395312
156Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73776878
157Mucopolysacchariduria (HP:0008155)1.73692245
158Urinary glycosaminoglycan excretion (HP:0003541)1.73692245
159Abnormality of eosinophils (HP:0001879)1.73044573
160Skin nodule (HP:0200036)1.72686888
161Autoimmune hemolytic anemia (HP:0001890)1.72405463
162Abnormality of aromatic amino acid family metabolism (HP:0004338)1.72291389
163Myopathic facies (HP:0002058)1.72083074
164Rapidly progressive (HP:0003678)1.71713050
165Ventricular arrhythmia (HP:0004308)1.71348951
166Malnutrition (HP:0004395)1.71091077
167Aortic aneurysm (HP:0004942)1.70255302
168Thin bony cortex (HP:0002753)1.69979932
169Achilles tendon contracture (HP:0001771)1.68728569
170Turricephaly (HP:0000262)1.68686853
171Hyperparathyroidism (HP:0000843)1.67994526
172Cellulitis (HP:0100658)1.67871588
173Disinhibition (HP:0000734)1.66725234
174Mildly elevated creatine phosphokinase (HP:0008180)1.66176474
175Depression (HP:0000716)1.65563445
176Axonal loss (HP:0003447)1.63980312
177Syncope (HP:0001279)1.61989617
178Myokymia (HP:0002411)1.60947292
179Hypercholesterolemia (HP:0003124)1.59544574
180Hammertoe (HP:0001765)1.58712874
181Decreased motor nerve conduction velocity (HP:0003431)1.56858644
182Mitral regurgitation (HP:0001653)1.56725779
183Increased cerebral lipofuscin (HP:0011813)1.55927537
184Nuclear cataract (HP:0100018)1.55560148
185Upper limb amyotrophy (HP:0009129)1.54351725
186Distal upper limb amyotrophy (HP:0007149)1.54351725
187Peripheral demyelination (HP:0011096)1.54284266
188Abnormality of glutamine family amino acid metabolism (HP:0010902)1.54185302
189Mutism (HP:0002300)1.54131324
190Stroke (HP:0001297)1.53638956
191Polycythemia (HP:0001901)1.53367899
192Diminished motivation (HP:0000745)1.53109086
193Papilledema (HP:0001085)1.52407031

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.37358220
2STK163.75925597
3RIPK13.44739154
4TRIB33.14500473
5CASK2.96440352
6TXK2.91920065
7IRAK42.71032249
8ERN12.55207321
9MUSK2.32920595
10NME22.28860871
11TEC2.25530573
12BLK2.22436257
13CDK192.18307542
14MAP3K142.17325266
15ADRBK22.11542732
16KIT2.09013175
17MAP4K12.05519795
18IRAK31.94594613
19TTN1.69027212
20DMPK1.67831220
21IKBKE1.67528171
22NTRK11.62178069
23KSR21.56280767
24LATS21.48405933
25NLK1.47350310
26MAP3K121.47317519
27MAP2K71.45731034
28RIPK41.45404028
29SIK11.44992159
30ICK1.44168401
31FES1.42879591
32MARK21.42600527
33PDGFRA1.42031110
34MAP2K31.38589671
35FRK1.34822854
36CDC42BPA1.33176795
37PAK61.31713233
38EIF2AK21.31432240
39MKNK21.30345956
40BTK1.30053891
41MAP3K131.29368737
42IRAK11.28564585
43STK391.27875582
44FGFR41.26358300
45TNK21.24894103
46CLK11.24240258
47YES11.23621358
48SYK1.23167193
49ARAF1.22792896
50GRK71.19765524
51BMPR1B1.19060529
52PDPK11.19030533
53PKN21.18422583
54EPHA41.14600189
55SGK31.14466624
56CAMKK21.13492020
57TAOK21.12741700
58TAOK11.12567974
59MAP3K11.10755535
60OXSR11.09326349
61IKBKB1.08275073
62LYN1.06720899
63GRK11.06409560
64CSF1R1.04155985
65MAPKAPK51.03829194
66BMPR21.03728441
67MAP3K91.03718639
68PRPF4B1.03620546
69MOS1.03210135
70EEF2K1.01129478
71DDR21.00726233
72CAMK1G1.00433435
73MAP3K60.99600821
74CAMKK10.98406935
75CAMK1D0.96913250
76DYRK1B0.96856778
77VRK10.96607327
78TBK10.94980207
79CDK120.94753121
80PRKD30.94635920
81PIK3CG0.93378403
82MARK10.92582458
83MAP3K110.91337227
84MKNK10.90421715
85ZAP700.90079079
86IRAK20.89520070
87PTK60.88355032
88LCK0.87176361
89PDK10.86936629
90LRRK20.86389912
91NEK60.85863304
92TAOK30.85373141
93MAPK120.85317289
94EPHB20.84874097
95MAP3K30.84716819
96PIM20.84511806
97SGK20.84463787
98ZAK0.84312216
99EIF2AK30.83472807
100ROCK20.83043824
101TGFBR20.82974301
102SGK2230.82485370
103SGK4940.82485370
104TLK10.82054055
105NUAK10.81666047
106RET0.81574999
107SIK30.80990401
108MAPK130.80717997
109TYK20.80356736
110PRKD20.79628481
111PTK20.79050908
112MAP3K20.78120988
113NEK90.77819500
114MAPK150.77729770
115JAK20.77025130
116MAP2K40.76745378
117RPS6KA20.74103576
118NTRK30.74010491
119CDK30.72848285
120NTRK20.72595805
121PRKG20.72502572
122DAPK20.72208467
123FGR0.71821191
124JAK10.71469675
125FLT30.70234464
126TRPM70.69458184
127MYLK0.68381252
128MAPK70.68375908
129JAK30.67210395
130OBSCN0.66082150
131MTOR0.65984187
132PDGFRB0.65817848
133WNK10.65671088
134MAP3K70.65474552
135PRKCH0.65464700
136INSRR0.64484965
137ABL20.63425121
138CAMK10.62614295
139BCR0.61328019
140STK380.61220600
141PKN10.60891678
142PRKCQ0.60668462
143UHMK10.60347344
144KSR10.60016123
145PRKD10.57742943
146CDK50.57379472
147CSNK1G30.56705005
148FGFR30.56493461
149MST40.55532962
150WNK40.55508406
151SMG10.54397512
152HCK0.54231766
153STK110.53815783
154TYRO30.52884460
155RPS6KL10.52657722
156RPS6KC10.52657722
157PRKAA20.52013685
158PLK40.51936618
159ERBB20.51802126
160PIK3CA0.51647666
161CSK0.50480378
162CAMK2B0.49414963
163CSNK1G10.46240298
164MAP2K60.46164056
165PRKCE0.45766502
166ITK0.45066266
167PBK0.44476449
168SRPK10.44190961
169CSNK1A1L0.43478125
170MATK0.43114163
171CHUK0.40648714
172CAMK2D0.39182877
173PRKCD0.37897942
174EPHB10.37803534
175TIE10.37740797
176EIF2AK10.36823871
177CAMK2G0.36777611
178MAP2K20.36762807
179BRAF0.35365856
180STK240.34375620

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.96226816
2Primary immunodeficiency_Homo sapiens_hsa053402.77106059
3Protein export_Homo sapiens_hsa030602.74592261
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.69782943
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.45187817
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.42638276
7Ribosome_Homo sapiens_hsa030102.09635540
8Autoimmune thyroid disease_Homo sapiens_hsa053201.97542585
9Hematopoietic cell lineage_Homo sapiens_hsa046401.95980033
10Allograft rejection_Homo sapiens_hsa053301.93486573
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90674260
12Other glycan degradation_Homo sapiens_hsa005111.86218453
13SNARE interactions in vesicular transport_Homo sapiens_hsa041301.84013146
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.82822553
15Sphingolipid metabolism_Homo sapiens_hsa006001.82766123
16Graft-versus-host disease_Homo sapiens_hsa053321.72992287
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.71345443
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64813990
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.62776043
20Complement and coagulation cascades_Homo sapiens_hsa046101.61657722
21Bile secretion_Homo sapiens_hsa049761.61515698
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59349496
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57871935
24Oxidative phosphorylation_Homo sapiens_hsa001901.56372046
25PPAR signaling pathway_Homo sapiens_hsa033201.54510515
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51606053
27Prion diseases_Homo sapiens_hsa050201.51283063
28Phenylalanine metabolism_Homo sapiens_hsa003601.50968359
29Non-homologous end-joining_Homo sapiens_hsa034501.50934268
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48157197
31Fatty acid elongation_Homo sapiens_hsa000621.46412557
32Measles_Homo sapiens_hsa051621.45231630
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.44419728
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43598735
35Arginine biosynthesis_Homo sapiens_hsa002201.42617609
36Ether lipid metabolism_Homo sapiens_hsa005651.40676960
37Arachidonic acid metabolism_Homo sapiens_hsa005901.40033578
38Asthma_Homo sapiens_hsa053101.38016735
39Folate biosynthesis_Homo sapiens_hsa007901.35938590
40Parkinsons disease_Homo sapiens_hsa050121.33212588
41Leishmaniasis_Homo sapiens_hsa051401.30119251
42Fatty acid degradation_Homo sapiens_hsa000711.26124912
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25739517
44Steroid biosynthesis_Homo sapiens_hsa001001.23579276
45Homologous recombination_Homo sapiens_hsa034401.21448500
46Regulation of autophagy_Homo sapiens_hsa041401.20201814
47Linoleic acid metabolism_Homo sapiens_hsa005911.19989219
48Long-term potentiation_Homo sapiens_hsa047201.17769835
49RNA polymerase_Homo sapiens_hsa030201.17531823
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16572704
51Rheumatoid arthritis_Homo sapiens_hsa053231.14566887
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.14323567
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13622471
54Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11815484
55Fanconi anemia pathway_Homo sapiens_hsa034601.10903736
56B cell receptor signaling pathway_Homo sapiens_hsa046621.09795846
57Cyanoamino acid metabolism_Homo sapiens_hsa004601.09483134
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09159962
59Primary bile acid biosynthesis_Homo sapiens_hsa001201.09093460
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08374553
61Malaria_Homo sapiens_hsa051441.08229117
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08068928
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06917584
64Sulfur metabolism_Homo sapiens_hsa009201.06366594
65Histidine metabolism_Homo sapiens_hsa003401.06049368
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04989717
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03576255
68Amoebiasis_Homo sapiens_hsa051461.02916816
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02697864
70Vitamin digestion and absorption_Homo sapiens_hsa049771.01492435
71Alzheimers disease_Homo sapiens_hsa050101.01024471
72Insulin signaling pathway_Homo sapiens_hsa049101.00108007
73Insulin resistance_Homo sapiens_hsa049310.98701768
74Pertussis_Homo sapiens_hsa051330.98301520
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98065133
76Pyrimidine metabolism_Homo sapiens_hsa002400.97920179
77ABC transporters_Homo sapiens_hsa020100.97434534
78GnRH signaling pathway_Homo sapiens_hsa049120.96305123
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.95653425
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95069088
81Herpes simplex infection_Homo sapiens_hsa051680.93997716
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90722416
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.90325404
84* Purine metabolism_Homo sapiens_hsa002300.90114803
85Base excision repair_Homo sapiens_hsa034100.89428153
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88612007
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87754281
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.87598834
89Starch and sucrose metabolism_Homo sapiens_hsa005000.85416297
90Renal cell carcinoma_Homo sapiens_hsa052110.85326103
91DNA replication_Homo sapiens_hsa030300.85177318
92VEGF signaling pathway_Homo sapiens_hsa043700.83758267
93Basal transcription factors_Homo sapiens_hsa030220.83384860
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.83282236
95African trypanosomiasis_Homo sapiens_hsa051430.82247758
96Dilated cardiomyopathy_Homo sapiens_hsa054140.82205578
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82021154
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.81040090
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78421965
100Arginine and proline metabolism_Homo sapiens_hsa003300.76937751
101Adherens junction_Homo sapiens_hsa045200.76843493
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76756756
103Tyrosine metabolism_Homo sapiens_hsa003500.76457512
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75501529
105Osteoclast differentiation_Homo sapiens_hsa043800.75429038
106Estrogen signaling pathway_Homo sapiens_hsa049150.75181906
107Serotonergic synapse_Homo sapiens_hsa047260.72542777
108Endometrial cancer_Homo sapiens_hsa052130.72329790
109Tuberculosis_Homo sapiens_hsa051520.70146739
110Fructose and mannose metabolism_Homo sapiens_hsa000510.69136188
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69107236
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69087713
113Gastric acid secretion_Homo sapiens_hsa049710.67949876
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67340215
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67125072
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66184513
117Chemical carcinogenesis_Homo sapiens_hsa052040.65832474
118Staphylococcus aureus infection_Homo sapiens_hsa051500.65631154
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.65507970
120Nicotine addiction_Homo sapiens_hsa050330.65313210
121Renin-angiotensin system_Homo sapiens_hsa046140.65218162
122AMPK signaling pathway_Homo sapiens_hsa041520.65177797
123Morphine addiction_Homo sapiens_hsa050320.64990728
124Renin secretion_Homo sapiens_hsa049240.64970763
125Notch signaling pathway_Homo sapiens_hsa043300.64898263
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64878781
127T cell receptor signaling pathway_Homo sapiens_hsa046600.64762258
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64377435
129Choline metabolism in cancer_Homo sapiens_hsa052310.64183490
130N-Glycan biosynthesis_Homo sapiens_hsa005100.63253597
131Huntingtons disease_Homo sapiens_hsa050160.63171045
132Type II diabetes mellitus_Homo sapiens_hsa049300.63162776
133ErbB signaling pathway_Homo sapiens_hsa040120.63110536
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62740925
135Chemokine signaling pathway_Homo sapiens_hsa040620.62700866
136Proteasome_Homo sapiens_hsa030500.62513037
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61302563
138Peroxisome_Homo sapiens_hsa041460.60997173
139Cholinergic synapse_Homo sapiens_hsa047250.60813016
140Influenza A_Homo sapiens_hsa051640.60694625
141Acute myeloid leukemia_Homo sapiens_hsa052210.59773115
142Caffeine metabolism_Homo sapiens_hsa002320.59593928
143Galactose metabolism_Homo sapiens_hsa000520.58296397
144Non-small cell lung cancer_Homo sapiens_hsa052230.57826394
145Chronic myeloid leukemia_Homo sapiens_hsa052200.57515479
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56715707
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.56321180
148Oxytocin signaling pathway_Homo sapiens_hsa049210.55656508
149Fatty acid metabolism_Homo sapiens_hsa012120.55155766
150Fat digestion and absorption_Homo sapiens_hsa049750.55145525
151Lysosome_Homo sapiens_hsa041420.54080909
152Thyroid hormone synthesis_Homo sapiens_hsa049180.53183152
153Hepatitis C_Homo sapiens_hsa051600.53170428
154Phagosome_Homo sapiens_hsa041450.53125015
155Type I diabetes mellitus_Homo sapiens_hsa049400.53057319
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52730973
157Protein digestion and absorption_Homo sapiens_hsa049740.52491097
158Focal adhesion_Homo sapiens_hsa045100.52328840
159Maturity onset diabetes of the young_Homo sapiens_hsa049500.52104067
160Carbon metabolism_Homo sapiens_hsa012000.51860489
161Endocytosis_Homo sapiens_hsa041440.51842753
162Glucagon signaling pathway_Homo sapiens_hsa049220.51658949
163Prolactin signaling pathway_Homo sapiens_hsa049170.51650057
164Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51628709
165Gap junction_Homo sapiens_hsa045400.51580740
166Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51192332
167Taste transduction_Homo sapiens_hsa047420.49843051
168Phototransduction_Homo sapiens_hsa047440.49228738
169Metabolic pathways_Homo sapiens_hsa011000.48496093
170Olfactory transduction_Homo sapiens_hsa047400.48108694
171Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47677482
172Retinol metabolism_Homo sapiens_hsa008300.46314692
173Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44410652
174Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43883214
175Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41876654
176TNF signaling pathway_Homo sapiens_hsa046680.39905677
177Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37715388
178Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37381045
179Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36128765
180Hepatitis B_Homo sapiens_hsa051610.36060763
181Legionellosis_Homo sapiens_hsa051340.35117168

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