

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | base-excision repair, AP site formation (GO:0006285) | 5.77148131 |
| 2 | ribosomal small subunit assembly (GO:0000028) | 5.76501215 |
| 3 | viral transcription (GO:0019083) | 5.32203038 |
| 4 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 5.11355991 |
| 5 | translational termination (GO:0006415) | 5.04863691 |
| 6 | ATP synthesis coupled proton transport (GO:0015986) | 5.00461012 |
| 7 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.00461012 |
| 8 | DNA deamination (GO:0045006) | 4.97675469 |
| 9 | ribosomal small subunit biogenesis (GO:0042274) | 4.94186675 |
| 10 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.91301074 |
| 11 | cotranslational protein targeting to membrane (GO:0006613) | 4.83627994 |
| 12 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.81942464 |
| 13 | protein targeting to ER (GO:0045047) | 4.73146356 |
| 14 | regulation of mitochondrial translation (GO:0070129) | 4.60237014 |
| 15 | protein localization to endoplasmic reticulum (GO:0070972) | 4.56934957 |
| 16 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.52460215 |
| 17 | translational elongation (GO:0006414) | 4.41918432 |
| 18 | pyrimidine nucleotide catabolic process (GO:0006244) | 4.41169847 |
| 19 | peptidyl-arginine omega-N-methylation (GO:0035247) | 4.37584179 |
| 20 | deoxyribonucleotide catabolic process (GO:0009264) | 4.36017337 |
| 21 | purine deoxyribonucleotide catabolic process (GO:0009155) | 4.32820653 |
| 22 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.24499928 |
| 23 | proteasome assembly (GO:0043248) | 4.24308081 |
| 24 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.16967922 |
| 25 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.14673490 |
| 26 | maturation of SSU-rRNA (GO:0030490) | 4.13367315 |
| 27 | viral life cycle (GO:0019058) | 4.13049998 |
| 28 | chaperone-mediated protein transport (GO:0072321) | 4.11719182 |
| 29 | termination of RNA polymerase III transcription (GO:0006386) | 4.05257191 |
| 30 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.05257191 |
| 31 | cellular protein complex disassembly (GO:0043624) | 4.00279605 |
| 32 | deoxyribose phosphate catabolic process (GO:0046386) | 3.96200666 |
| 33 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.92620845 |
| 34 | NADH dehydrogenase complex assembly (GO:0010257) | 3.92620845 |
| 35 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.92620845 |
| 36 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.91832315 |
| 37 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.91005310 |
| 38 | negative regulation of ligase activity (GO:0051352) | 3.91005310 |
| 39 | rRNA modification (GO:0000154) | 3.89922832 |
| 40 | protein complex biogenesis (GO:0070271) | 3.88960972 |
| 41 | translational initiation (GO:0006413) | 3.84957541 |
| 42 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.81299710 |
| 43 | respiratory electron transport chain (GO:0022904) | 3.80184445 |
| 44 | translation (GO:0006412) | 3.79768571 |
| 45 | establishment of integrated proviral latency (GO:0075713) | 3.78752981 |
| 46 | electron transport chain (GO:0022900) | 3.77896230 |
| 47 | amino acid salvage (GO:0043102) | 3.75413007 |
| 48 | L-methionine salvage (GO:0071267) | 3.75413007 |
| 49 | L-methionine biosynthetic process (GO:0071265) | 3.75413007 |
| 50 | histone arginine methylation (GO:0034969) | 3.74724531 |
| 51 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.74601874 |
| 52 | central nervous system myelination (GO:0022010) | 3.72307649 |
| 53 | axon ensheathment in central nervous system (GO:0032291) | 3.72307649 |
| 54 | protein insertion into membrane (GO:0051205) | 3.69700349 |
| 55 | cullin deneddylation (GO:0010388) | 3.67960673 |
| 56 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 3.65706357 |
| 57 | respiratory chain complex IV assembly (GO:0008535) | 3.65305727 |
| 58 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.64590106 |
| 59 | protein complex disassembly (GO:0043241) | 3.61102425 |
| 60 | DNA damage response, detection of DNA damage (GO:0042769) | 3.60606679 |
| 61 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.56477074 |
| 62 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.55411288 |
| 63 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.55255221 |
| 64 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.52521457 |
| 65 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.50798532 |
| 66 | protein deneddylation (GO:0000338) | 3.50665275 |
| 67 | protein maturation by protein folding (GO:0022417) | 3.49417041 |
| 68 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.47627732 |
| 69 | GTP biosynthetic process (GO:0006183) | 3.46717043 |
| 70 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.44802397 |
| 71 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.44802397 |
| 72 | macromolecular complex disassembly (GO:0032984) | 3.40337715 |
| 73 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 3.40039903 |
| 74 | peptidyl-arginine methylation (GO:0018216) | 3.39907325 |
| 75 | peptidyl-arginine N-methylation (GO:0035246) | 3.39907325 |
| 76 | 7-methylguanosine mRNA capping (GO:0006370) | 3.39538864 |
| 77 | protein localization to mitochondrion (GO:0070585) | 3.39322479 |
| 78 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.38873798 |
| 79 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.38873798 |
| 80 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.38873798 |
| 81 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.37055283 |
| 82 | metallo-sulfur cluster assembly (GO:0031163) | 3.36125393 |
| 83 | iron-sulfur cluster assembly (GO:0016226) | 3.36125393 |
| 84 | 7-methylguanosine RNA capping (GO:0009452) | 3.33502865 |
| 85 | RNA capping (GO:0036260) | 3.33502865 |
| 86 | establishment of viral latency (GO:0019043) | 3.33344400 |
| 87 | inner mitochondrial membrane organization (GO:0007007) | 3.29202017 |
| 88 | peptidyl-histidine modification (GO:0018202) | 3.28685684 |
| 89 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.27603049 |
| 90 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.27603049 |
| 91 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.23987766 |
| 92 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.23563950 |
| 93 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.23454672 |
| 94 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.23454672 |
| 95 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.21182589 |
| 96 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.20361931 |
| 97 | purine deoxyribonucleotide metabolic process (GO:0009151) | 3.20092863 |
| 98 | protein targeting to membrane (GO:0006612) | 3.16744609 |
| 99 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.14301516 |
| 100 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.14301516 |
| 101 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.13766202 |
| 102 | cellular component biogenesis (GO:0044085) | 3.12888377 |
| 103 | protein targeting to mitochondrion (GO:0006626) | 3.06643100 |
| 104 | deoxyribose phosphate metabolic process (GO:0019692) | 3.04671540 |
| 105 | sequestering of actin monomers (GO:0042989) | 3.04598814 |
| 106 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.04177636 |
| 107 | UTP biosynthetic process (GO:0006228) | 3.03519698 |
| 108 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.03240306 |
| 109 | GDP-mannose metabolic process (GO:0019673) | 3.01882157 |
| 110 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.01792489 |
| 111 | spliceosomal snRNP assembly (GO:0000387) | 3.01189915 |
| 112 | regulation of autophagic vacuole assembly (GO:2000785) | 3.00843860 |
| 113 | mannosylation (GO:0097502) | 3.00360543 |
| 114 | establishment of protein localization to mitochondrion (GO:0072655) | 3.00345750 |
| 115 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.99790368 |
| 116 | fatty acid elongation (GO:0030497) | 2.98338354 |
| 117 | rRNA processing (GO:0006364) | 2.98296120 |
| 118 | ribosomal large subunit biogenesis (GO:0042273) | 2.96425385 |
| 119 | cytochrome complex assembly (GO:0017004) | 2.96025581 |
| 120 | CTP metabolic process (GO:0046036) | 2.95288767 |
| 121 | CTP biosynthetic process (GO:0006241) | 2.95288767 |
| 122 | hydrogen ion transmembrane transport (GO:1902600) | 2.94952294 |
| 123 | oxidative phosphorylation (GO:0006119) | 2.94528421 |
| 124 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.94047910 |
| 125 | pentose metabolic process (GO:0019321) | 2.93689707 |
| 126 | positive regulation of TOR signaling (GO:0032008) | 2.93222661 |
| 127 | regulation of cellular amine metabolic process (GO:0033238) | 2.92287352 |
| 128 | protein neddylation (GO:0045116) | 2.91831234 |
| 129 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.91735735 |
| 130 | purine ribonucleotide transport (GO:0015868) | 2.89139765 |
| 131 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.88538906 |
| 132 | ATP biosynthetic process (GO:0006754) | 2.88344684 |
| 133 | GPI anchor biosynthetic process (GO:0006506) | 2.88115482 |
| 134 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.88039055 |
| 135 | adenine nucleotide transport (GO:0051503) | 2.87561099 |
| 136 | viral protein processing (GO:0019082) | 2.87520634 |
| 137 | protein localization to cilium (GO:0061512) | 2.86811052 |
| 138 | pseudouridine synthesis (GO:0001522) | 2.86154594 |
| 139 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.85401991 |
| 140 | C-terminal protein lipidation (GO:0006501) | 2.85288806 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 5.40832201 |
| 2 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 5.27027003 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.53775911 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.30355910 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.26901902 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.00325519 |
| 7 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.77085088 |
| 8 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.70578161 |
| 9 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.64672106 |
| 10 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.62087146 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.60156418 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.36038124 |
| 13 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.34687972 |
| 14 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.97721161 |
| 15 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.96944675 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.84461773 |
| 17 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.79460041 |
| 18 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.68902641 |
| 19 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.55201007 |
| 20 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.42021963 |
| 21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.39349711 |
| 22 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.37917248 |
| 23 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.37170301 |
| 24 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.36639316 |
| 25 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.32889791 |
| 26 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.20515947 |
| 27 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.16818515 |
| 28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.12873227 |
| 29 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.05953824 |
| 30 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.04594508 |
| 31 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.02538772 |
| 32 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.01134983 |
| 33 | LXR_22292898_ChIP-Seq_THP-1_Human | 2.00129419 |
| 34 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.95304522 |
| 35 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.93411360 |
| 36 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.92420024 |
| 37 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.91597675 |
| 38 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.90102644 |
| 39 | P68_20966046_ChIP-Seq_HELA_Human | 1.88876161 |
| 40 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.87314108 |
| 41 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.75827880 |
| 42 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.65659519 |
| 43 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.65172489 |
| 44 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.64762390 |
| 45 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.61940944 |
| 46 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.61012754 |
| 47 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.60918684 |
| 48 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.58175566 |
| 49 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.56040389 |
| 50 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.51208281 |
| 51 | * SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.50219136 |
| 52 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.49655201 |
| 53 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.48404412 |
| 54 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.44312634 |
| 55 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.42997287 |
| 56 | * MAF_26560356_Chip-Seq_TH2_Human | 1.40610526 |
| 57 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.40572618 |
| 58 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.40207958 |
| 59 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.38574227 |
| 60 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.37519676 |
| 61 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.37305081 |
| 62 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.36648422 |
| 63 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.36638276 |
| 64 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.35983466 |
| 65 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.35334257 |
| 66 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.35011131 |
| 67 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.33058917 |
| 68 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.31511865 |
| 69 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.29776888 |
| 70 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.29690974 |
| 71 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.29292310 |
| 72 | SA1_27219007_Chip-Seq_Bcells_Human | 1.29210824 |
| 73 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.28628625 |
| 74 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.28500419 |
| 75 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.28131564 |
| 76 | CTCF_21964334_Chip-Seq_Bcells_Human | 1.26291228 |
| 77 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.25758462 |
| 78 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.25503950 |
| 79 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.24024962 |
| 80 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.23252493 |
| 81 | * RARB_24833708_ChIP-Seq_LIVER_Mouse | 1.21229192 |
| 82 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.19912812 |
| 83 | CTCF_20526341_ChIP-Seq_ESCs_Human | 1.17926155 |
| 84 | UTX_26944678_Chip-Seq_JUKART_Human | 1.17481002 |
| 85 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.15226801 |
| 86 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.15058622 |
| 87 | MYC_22102868_ChIP-Seq_BL_Human | 1.14818584 |
| 88 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.14179225 |
| 89 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.13162539 |
| 90 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.12039827 |
| 91 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.12036835 |
| 92 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 1.10894873 |
| 93 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.10123123 |
| 94 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.09544781 |
| 95 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.09292129 |
| 96 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.09225478 |
| 97 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.09095003 |
| 98 | * RARA_24833708_ChIP-Seq_LIVER_Mouse | 1.08264086 |
| 99 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.08245075 |
| 100 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.08115832 |
| 101 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.08061725 |
| 102 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.07143209 |
| 103 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 1.07069025 |
| 104 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.05592051 |
| 105 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.05525113 |
| 106 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.05491291 |
| 107 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.04737723 |
| 108 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.04271793 |
| 109 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.04078750 |
| 110 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.03935179 |
| 111 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.03341761 |
| 112 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.02093329 |
| 113 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.98916800 |
| 114 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.98809936 |
| 115 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.98010839 |
| 116 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.94323517 |
| 117 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.91670559 |
| 118 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.91511479 |
| 119 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.90778786 |
| 120 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.85350669 |
| 121 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.84535625 |
| 122 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 0.83299952 |
| 123 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.82461657 |
| 124 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.82186939 |
| 125 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.81588015 |
| 126 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.81147356 |
| 127 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.80895210 |
| 128 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.80692469 |
| 129 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.79860397 |
| 130 | * VDR_21846776_ChIP-Seq_THP-1_Human | 0.78890526 |
| 131 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.77607567 |
| 132 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.77527281 |
| 133 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.76703933 |
| 134 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.74456791 |
| 135 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.74119577 |
| 136 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.73420701 |
| 137 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.73008575 |
| 138 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.71605416 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0006292_abnormal_olfactory_placode | 3.05861953 |
| 2 | MP0005423_abnormal_somatic_nervous | 2.78573377 |
| 3 | MP0001905_abnormal_dopamine_level | 2.72124608 |
| 4 | MP0005075_abnormal_melanosome_morpholog | 2.70490276 |
| 5 | MP0001529_abnormal_vocalization | 2.69654445 |
| 6 | MP0003880_abnormal_central_pattern | 2.44405609 |
| 7 | MP0005174_abnormal_tail_pigmentation | 2.35596643 |
| 8 | MP0009379_abnormal_foot_pigmentation | 2.33803257 |
| 9 | MP0004133_heterotaxia | 2.30634493 |
| 10 | MP0005409_darkened_coat_color | 2.29349972 |
| 11 | MP0001986_abnormal_taste_sensitivity | 2.15447892 |
| 12 | MP0000372_irregular_coat_pigmentation | 2.15323135 |
| 13 | MP0000015_abnormal_ear_pigmentation | 2.05028276 |
| 14 | MP0008789_abnormal_olfactory_epithelium | 1.98571725 |
| 15 | MP0005058_abnormal_lysosome_morphology | 1.96173187 |
| 16 | MP0003787_abnormal_imprinting | 1.95443060 |
| 17 | MP0000678_abnormal_parathyroid_gland | 1.90225463 |
| 18 | MP0003011_delayed_dark_adaptation | 1.88262805 |
| 19 | MP0009840_abnormal_foam_cell | 1.83452675 |
| 20 | MP0003315_abnormal_perineum_morphology | 1.80065101 |
| 21 | MP0000920_abnormal_myelination | 1.78842247 |
| 22 | MP0000049_abnormal_middle_ear | 1.76516743 |
| 23 | MP0005499_abnormal_olfactory_system | 1.76488153 |
| 24 | MP0005394_taste/olfaction_phenotype | 1.76488153 |
| 25 | MP0001849_ear_inflammation | 1.75790828 |
| 26 | MP0002822_catalepsy | 1.75514830 |
| 27 | MP0002938_white_spotting | 1.72008409 |
| 28 | MP0000750_abnormal_muscle_regeneration | 1.68050988 |
| 29 | MP0002653_abnormal_ependyma_morphology | 1.67380750 |
| 30 | MP0003136_yellow_coat_color | 1.66797709 |
| 31 | MP0003786_premature_aging | 1.66626967 |
| 32 | MP0003693_abnormal_embryo_hatching | 1.64157889 |
| 33 | MP0000681_abnormal_thyroid_gland | 1.60493421 |
| 34 | MP0005671_abnormal_response_to | 1.59787271 |
| 35 | MP0008058_abnormal_DNA_repair | 1.57975676 |
| 36 | MP0006036_abnormal_mitochondrial_physio | 1.56731114 |
| 37 | MP0005377_hearing/vestibular/ear_phenot | 1.52917423 |
| 38 | MP0003878_abnormal_ear_physiology | 1.52917423 |
| 39 | MP0008932_abnormal_embryonic_tissue | 1.51502668 |
| 40 | MP0002095_abnormal_skin_pigmentation | 1.50406221 |
| 41 | MP0002736_abnormal_nociception_after | 1.48898822 |
| 42 | MP0003806_abnormal_nucleotide_metabolis | 1.48294359 |
| 43 | MP0001968_abnormal_touch/_nociception | 1.47029657 |
| 44 | MP0002272_abnormal_nervous_system | 1.44939152 |
| 45 | MP0003763_abnormal_thymus_physiology | 1.44692059 |
| 46 | MP0002396_abnormal_hematopoietic_system | 1.42921376 |
| 47 | MP0002751_abnormal_autonomic_nervous | 1.42597914 |
| 48 | MP0004957_abnormal_blastocyst_morpholog | 1.42531740 |
| 49 | MP0004142_abnormal_muscle_tone | 1.42040252 |
| 50 | MP0001485_abnormal_pinna_reflex | 1.40048751 |
| 51 | MP0003122_maternal_imprinting | 1.39801926 |
| 52 | MP0001727_abnormal_embryo_implantation | 1.38792347 |
| 53 | MP0008057_abnormal_DNA_replication | 1.36650452 |
| 54 | MP0001764_abnormal_homeostasis | 1.33017482 |
| 55 | MP0010030_abnormal_orbit_morphology | 1.30600012 |
| 56 | MP0005083_abnormal_biliary_tract | 1.28721429 |
| 57 | MP0008260_abnormal_autophagy | 1.28003278 |
| 58 | MP0003866_abnormal_defecation | 1.25890589 |
| 59 | MP0003186_abnormal_redox_activity | 1.25778577 |
| 60 | MP0002163_abnormal_gland_morphology | 1.25220496 |
| 61 | MP0000358_abnormal_cell_content/ | 1.25011492 |
| 62 | MP0002102_abnormal_ear_morphology | 1.23307410 |
| 63 | MP0008995_early_reproductive_senescence | 1.22786915 |
| 64 | MP0005330_cardiomyopathy | 1.22460051 |
| 65 | MP0003137_abnormal_impulse_conducting | 1.22246627 |
| 66 | MP0002148_abnormal_hypersensitivity_rea | 1.21677203 |
| 67 | MP0005645_abnormal_hypothalamus_physiol | 1.21659068 |
| 68 | MP0003938_abnormal_ear_development | 1.20600376 |
| 69 | MP0009333_abnormal_splenocyte_physiolog | 1.18547810 |
| 70 | MP0000631_abnormal_neuroendocrine_gland | 1.18239206 |
| 71 | MP0001963_abnormal_hearing_physiology | 1.18161871 |
| 72 | MP0006072_abnormal_retinal_apoptosis | 1.16862512 |
| 73 | MP0000751_myopathy | 1.14542070 |
| 74 | MP0003718_maternal_effect | 1.12498956 |
| 75 | MP0006054_spinal_hemorrhage | 1.12085350 |
| 76 | MP0005451_abnormal_body_composition | 1.07831346 |
| 77 | MP0002160_abnormal_reproductive_system | 1.07659825 |
| 78 | MP0002909_abnormal_adrenal_gland | 1.07267778 |
| 79 | MP0001502_abnormal_circadian_rhythm | 1.05122795 |
| 80 | MP0003172_abnormal_lysosome_physiology | 1.04900350 |
| 81 | MP0000465_gastrointestinal_hemorrhage | 1.04174963 |
| 82 | MP0005408_hypopigmentation | 1.03724378 |
| 83 | MP0002638_abnormal_pupillary_reflex | 1.02371221 |
| 84 | MP0001919_abnormal_reproductive_system | 1.02150302 |
| 85 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.01383965 |
| 86 | MP0001661_extended_life_span | 1.01060742 |
| 87 | MP0003436_decreased_susceptibility_to | 1.00631898 |
| 88 | MP0004742_abnormal_vestibular_system | 1.00609847 |
| 89 | MP0008877_abnormal_DNA_methylation | 1.00227259 |
| 90 | MP0006035_abnormal_mitochondrial_morpho | 0.99702898 |
| 91 | MP0000538_abnormal_urinary_bladder | 0.98219419 |
| 92 | MP0002132_abnormal_respiratory_system | 0.97680594 |
| 93 | MP0004270_analgesia | 0.96875696 |
| 94 | MP0003077_abnormal_cell_cycle | 0.94888590 |
| 95 | MP0000685_abnormal_immune_system | 0.93480373 |
| 96 | MP0005379_endocrine/exocrine_gland_phen | 0.93447615 |
| 97 | MP0004043_abnormal_pH_regulation | 0.93052196 |
| 98 | MP0003123_paternal_imprinting | 0.92995313 |
| 99 | MP0001970_abnormal_pain_threshold | 0.92849522 |
| 100 | MP0000490_abnormal_crypts_of | 0.91739779 |
| 101 | MP0004885_abnormal_endolymph | 0.90648822 |
| 102 | MP0006276_abnormal_autonomic_nervous | 0.90377895 |
| 103 | MP0000749_muscle_degeneration | 0.89643294 |
| 104 | MP0001542_abnormal_bone_strength | 0.88990101 |
| 105 | MP0002064_seizures | 0.88979272 |
| 106 | MP0001984_abnormal_olfaction | 0.88918542 |
| 107 | MP0010094_abnormal_chromosome_stability | 0.88524304 |
| 108 | MP0000689_abnormal_spleen_morphology | 0.88444774 |
| 109 | MP0002398_abnormal_bone_marrow | 0.88133030 |
| 110 | MP0002752_abnormal_somatic_nervous | 0.87885717 |
| 111 | MP0002733_abnormal_thermal_nociception | 0.87637110 |
| 112 | MP0000026_abnormal_inner_ear | 0.87342267 |
| 113 | MP0002723_abnormal_immune_serum | 0.85091650 |
| 114 | MP0004858_abnormal_nervous_system | 0.84833485 |
| 115 | MP0002229_neurodegeneration | 0.82466288 |
| 116 | MP0002734_abnormal_mechanical_nocicepti | 0.81658241 |
| 117 | MP0005171_absent_coat_pigmentation | 0.81069091 |
| 118 | MP0005646_abnormal_pituitary_gland | 0.80896807 |
| 119 | MP0001188_hyperpigmentation | 0.80412729 |
| 120 | MP0009745_abnormal_behavioral_response | 0.80179023 |
| 121 | MP0004381_abnormal_hair_follicle | 0.79652044 |
| 122 | MP0002277_abnormal_respiratory_mucosa | 0.79637219 |
| 123 | MP0002420_abnormal_adaptive_immunity | 0.79620850 |
| 124 | MP0004859_abnormal_synaptic_plasticity | 0.78312495 |
| 125 | MP0003121_genomic_imprinting | 0.78186196 |
| 126 | MP0002837_dystrophic_cardiac_calcinosis | 0.77614858 |
| 127 | MP0002722_abnormal_immune_system | 0.77390868 |
| 128 | MP0009697_abnormal_copulation | 0.76422000 |
| 129 | MP0002234_abnormal_pharynx_morphology | 0.76385013 |
| 130 | MP0003879_abnormal_hair_cell | 0.76174728 |
| 131 | MP0005310_abnormal_salivary_gland | 0.75976472 |
| 132 | MP0000716_abnormal_immune_system | 0.75480799 |
| 133 | MP0001819_abnormal_immune_cell | 0.75160505 |
| 134 | MP0002249_abnormal_larynx_morphology | 0.74337744 |
| 135 | MP0005253_abnormal_eye_physiology | 0.74097983 |
| 136 | MP0009785_altered_susceptibility_to | 0.72427716 |
| 137 | MP0008007_abnormal_cellular_replicative | 0.71942830 |
| 138 | MP0005025_abnormal_response_to | 0.71214105 |
| 139 | MP0002882_abnormal_neuron_morphology | 0.71184762 |
| 140 | MP0002429_abnormal_blood_cell | 0.70682258 |
| 141 | MP0005332_abnormal_amino_acid | 0.70099901 |
| 142 | MP0002067_abnormal_sensory_capabilities | 0.69642283 |
| 143 | MP0008872_abnormal_physiological_respon | 0.69605480 |
| 144 | MP0005319_abnormal_enzyme/_coenzyme | 0.69070525 |
| 145 | MP0005551_abnormal_eye_electrophysiolog | 0.66279602 |
| 146 | MP0009643_abnormal_urine_homeostasis | 0.66202979 |
| 147 | MP0008875_abnormal_xenobiotic_pharmacok | 0.66118894 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Cerebral hypomyelination (HP:0006808) | 5.13159053 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 5.02130524 |
| 3 | Hepatocellular necrosis (HP:0001404) | 4.70179096 |
| 4 | Mitochondrial inheritance (HP:0001427) | 4.57449424 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.56863200 |
| 6 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.17612821 |
| 7 | Increased CSF lactate (HP:0002490) | 4.06602845 |
| 8 | Hepatic necrosis (HP:0002605) | 4.04823072 |
| 9 | Abnormal number of erythroid precursors (HP:0012131) | 3.98481389 |
| 10 | Acute encephalopathy (HP:0006846) | 3.96594202 |
| 11 | Stenosis of the external auditory canal (HP:0000402) | 3.84069775 |
| 12 | Progressive macrocephaly (HP:0004481) | 3.81431196 |
| 13 | Type I transferrin isoform profile (HP:0003642) | 3.69957784 |
| 14 | Testicular atrophy (HP:0000029) | 3.68860168 |
| 15 | Increased serum pyruvate (HP:0003542) | 3.62599574 |
| 16 | Abnormality of glycolysis (HP:0004366) | 3.62599574 |
| 17 | 3-Methylglutaconic aciduria (HP:0003535) | 3.53181586 |
| 18 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.50726088 |
| 19 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.50526484 |
| 20 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.50526484 |
| 21 | Leukodystrophy (HP:0002415) | 3.36419613 |
| 22 | CNS hypomyelination (HP:0003429) | 3.32342742 |
| 23 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.31297570 |
| 24 | Renal Fanconi syndrome (HP:0001994) | 3.24154489 |
| 25 | Increased hepatocellular lipid droplets (HP:0006565) | 3.19729432 |
| 26 | Increased serum lactate (HP:0002151) | 3.16728273 |
| 27 | Ragged-red muscle fibers (HP:0003200) | 2.99172251 |
| 28 | Hypothermia (HP:0002045) | 2.93549333 |
| 29 | Respiratory failure (HP:0002878) | 2.92391013 |
| 30 | Myokymia (HP:0002411) | 2.87398670 |
| 31 | Lactic acidosis (HP:0003128) | 2.86723359 |
| 32 | Reticulocytopenia (HP:0001896) | 2.85798277 |
| 33 | Severe visual impairment (HP:0001141) | 2.82539653 |
| 34 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.77810665 |
| 35 | Dicarboxylic aciduria (HP:0003215) | 2.77810665 |
| 36 | Macrocytic anemia (HP:0001972) | 2.76844610 |
| 37 | Lipid accumulation in hepatocytes (HP:0006561) | 2.76783946 |
| 38 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.76246881 |
| 39 | True hermaphroditism (HP:0010459) | 2.74405692 |
| 40 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.68874721 |
| 41 | Abnormal protein glycosylation (HP:0012346) | 2.68874721 |
| 42 | Abnormal glycosylation (HP:0012345) | 2.68874721 |
| 43 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.68874721 |
| 44 | Poor suck (HP:0002033) | 2.67060015 |
| 45 | Exercise intolerance (HP:0003546) | 2.65660924 |
| 46 | Hyperglycinemia (HP:0002154) | 2.65034487 |
| 47 | Morphological abnormality of the inner ear (HP:0011390) | 2.61374977 |
| 48 | Abnormality of cochlea (HP:0000375) | 2.51584680 |
| 49 | Aplastic anemia (HP:0001915) | 2.51102962 |
| 50 | Failure to thrive in infancy (HP:0001531) | 2.48249334 |
| 51 | Increased intramyocellular lipid droplets (HP:0012240) | 2.47177464 |
| 52 | Myopathic facies (HP:0002058) | 2.45263252 |
| 53 | Rib fusion (HP:0000902) | 2.42919798 |
| 54 | Emotional lability (HP:0000712) | 2.41488070 |
| 55 | Spastic paraparesis (HP:0002313) | 2.41304056 |
| 56 | Progressive microcephaly (HP:0000253) | 2.40740449 |
| 57 | CNS demyelination (HP:0007305) | 2.39300130 |
| 58 | Reduced antithrombin III activity (HP:0001976) | 2.38968546 |
| 59 | Chronic sinusitis (HP:0011109) | 2.37809399 |
| 60 | Abnormality of the renal collecting system (HP:0004742) | 2.35471932 |
| 61 | Pancreatic cysts (HP:0001737) | 2.32829784 |
| 62 | Cerebral edema (HP:0002181) | 2.32377929 |
| 63 | Pallor (HP:0000980) | 2.31551376 |
| 64 | Opisthotonus (HP:0002179) | 2.31385360 |
| 65 | Exertional dyspnea (HP:0002875) | 2.28776684 |
| 66 | Muscle fiber atrophy (HP:0100295) | 2.28211622 |
| 67 | Optic disc pallor (HP:0000543) | 2.27465822 |
| 68 | Delusions (HP:0000746) | 2.26391123 |
| 69 | Microretrognathia (HP:0000308) | 2.24717514 |
| 70 | Methylmalonic aciduria (HP:0012120) | 2.24679974 |
| 71 | Parakeratosis (HP:0001036) | 2.22998918 |
| 72 | Postnatal microcephaly (HP:0005484) | 2.22846346 |
| 73 | Abnormality of magnesium homeostasis (HP:0004921) | 2.22230338 |
| 74 | Retinal dysplasia (HP:0007973) | 2.21830378 |
| 75 | Pancreatic fibrosis (HP:0100732) | 2.21315161 |
| 76 | Lethargy (HP:0001254) | 2.10987548 |
| 77 | Asplenia (HP:0001746) | 2.08528524 |
| 78 | Polyphagia (HP:0002591) | 2.06507959 |
| 79 | Split foot (HP:0001839) | 2.05480458 |
| 80 | Respiratory difficulties (HP:0002880) | 2.04843402 |
| 81 | Neuroendocrine neoplasm (HP:0100634) | 2.03587755 |
| 82 | Cerebral palsy (HP:0100021) | 2.03449548 |
| 83 | Abnormality of renal resorption (HP:0011038) | 2.01814799 |
| 84 | Increased muscle lipid content (HP:0009058) | 2.01653235 |
| 85 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.01512790 |
| 86 | Medial flaring of the eyebrow (HP:0010747) | 1.99088347 |
| 87 | Thrombocytosis (HP:0001894) | 1.98431927 |
| 88 | Type 2 muscle fiber atrophy (HP:0003554) | 1.98280521 |
| 89 | Hypomagnesemia (HP:0002917) | 1.98017217 |
| 90 | Dry hair (HP:0011359) | 1.96441576 |
| 91 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.96423970 |
| 92 | Congenital malformation of the right heart (HP:0011723) | 1.95477257 |
| 93 | Double outlet right ventricle (HP:0001719) | 1.95477257 |
| 94 | Recurrent bronchitis (HP:0002837) | 1.95352952 |
| 95 | Nasolacrimal duct obstruction (HP:0000579) | 1.92743991 |
| 96 | Hypoplasia of the thymus (HP:0000778) | 1.92430692 |
| 97 | Prolonged neonatal jaundice (HP:0006579) | 1.91701576 |
| 98 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.90762448 |
| 99 | Rhabdomyolysis (HP:0003201) | 1.89309224 |
| 100 | Increased IgM level (HP:0003496) | 1.88469525 |
| 101 | Hyperglycinuria (HP:0003108) | 1.87127177 |
| 102 | Myotonia (HP:0002486) | 1.85836484 |
| 103 | Abnormal gallbladder physiology (HP:0012438) | 1.83650095 |
| 104 | Cholecystitis (HP:0001082) | 1.83650095 |
| 105 | Concave nail (HP:0001598) | 1.83626014 |
| 106 | Microvesicular hepatic steatosis (HP:0001414) | 1.83172382 |
| 107 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.82525830 |
| 108 | Abnormality of glycine metabolism (HP:0010895) | 1.82525830 |
| 109 | Nephrogenic diabetes insipidus (HP:0009806) | 1.80645420 |
| 110 | Unsteady gait (HP:0002317) | 1.80474465 |
| 111 | Optic nerve coloboma (HP:0000588) | 1.77935921 |
| 112 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.77052730 |
| 113 | Anencephaly (HP:0002323) | 1.75788607 |
| 114 | Congenital primary aphakia (HP:0007707) | 1.73613264 |
| 115 | Pheochromocytoma (HP:0002666) | 1.72928867 |
| 116 | Gait imbalance (HP:0002141) | 1.72132661 |
| 117 | IgM deficiency (HP:0002850) | 1.72103840 |
| 118 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.71779928 |
| 119 | Renal salt wasting (HP:0000127) | 1.70851077 |
| 120 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.70346051 |
| 121 | Anomalous pulmonary venous return (HP:0010772) | 1.69499678 |
| 122 | Partial duplication of thumb phalanx (HP:0009944) | 1.68716120 |
| 123 | 11 pairs of ribs (HP:0000878) | 1.68664955 |
| 124 | Ketosis (HP:0001946) | 1.68416200 |
| 125 | Progressive neurologic deterioration (HP:0002344) | 1.68176298 |
| 126 | Gliosis (HP:0002171) | 1.67752286 |
| 127 | Vomiting (HP:0002013) | 1.67495792 |
| 128 | Hyperphosphaturia (HP:0003109) | 1.66618096 |
| 129 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.66376918 |
| 130 | Absent thumb (HP:0009777) | 1.65518285 |
| 131 | Chronic otitis media (HP:0000389) | 1.65266035 |
| 132 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.64368748 |
| 133 | Broad distal phalanx of finger (HP:0009836) | 1.64349831 |
| 134 | Progressive muscle weakness (HP:0003323) | 1.64103751 |
| 135 | Annular pancreas (HP:0001734) | 1.63644724 |
| 136 | Hypoplastic pelvis (HP:0008839) | 1.63143242 |
| 137 | Obstructive lung disease (HP:0006536) | 1.62616777 |
| 138 | Chronic obstructive pulmonary disease (HP:0006510) | 1.62616777 |
| 139 | Renal tubular dysfunction (HP:0000124) | 1.60966765 |
| 140 | Renal cortical cysts (HP:0000803) | 1.60591431 |
| 141 | Hepatosplenomegaly (HP:0001433) | 1.60327859 |
| 142 | Pancytopenia (HP:0001876) | 1.60287993 |
| 143 | Truncus arteriosus (HP:0001660) | 1.58260040 |
| 144 | Severe global developmental delay (HP:0011344) | 1.57259332 |
| 145 | Abnormal urine phosphate concentration (HP:0012599) | 1.57090045 |
| 146 | Hypoplastic heart (HP:0001961) | 1.57047230 |
| 147 | Sclerocornea (HP:0000647) | 1.56776551 |
| 148 | Generalized aminoaciduria (HP:0002909) | 1.55928986 |
| 149 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 1.54419415 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | STK16 | 4.42679773 |
| 2 | VRK2 | 3.33322898 |
| 3 | BCR | 3.26225942 |
| 4 | BUB1 | 3.01190787 |
| 5 | TNIK | 2.88811439 |
| 6 | PASK | 2.82413023 |
| 7 | CDK19 | 2.69463903 |
| 8 | STK39 | 2.53015108 |
| 9 | TESK2 | 2.50397054 |
| 10 | MAPKAPK5 | 2.50016407 |
| 11 | NME2 | 2.35169207 |
| 12 | VRK1 | 2.31381006 |
| 13 | MKNK1 | 2.12079733 |
| 14 | NME1 | 1.92461341 |
| 15 | MAP3K12 | 1.85118896 |
| 16 | WEE1 | 1.84689512 |
| 17 | OXSR1 | 1.81671802 |
| 18 | MAPK15 | 1.80086740 |
| 19 | SIK3 | 1.78398063 |
| 20 | GRK6 | 1.66369392 |
| 21 | CCNB1 | 1.59583733 |
| 22 | CSNK1G3 | 1.55202327 |
| 23 | ADRBK2 | 1.51109300 |
| 24 | EIF2AK1 | 1.47310360 |
| 25 | ARAF | 1.42616272 |
| 26 | SRPK1 | 1.39873070 |
| 27 | UHMK1 | 1.39612289 |
| 28 | WNK4 | 1.30419279 |
| 29 | TSSK6 | 1.29178789 |
| 30 | BRSK2 | 1.25521158 |
| 31 | EIF2AK3 | 1.24162786 |
| 32 | TRIB3 | 1.23174463 |
| 33 | LIMK1 | 1.22579154 |
| 34 | BCKDK | 1.18437893 |
| 35 | TNK2 | 1.16994250 |
| 36 | MUSK | 1.15939207 |
| 37 | ERN1 | 1.15466369 |
| 38 | MAP4K1 | 1.15351047 |
| 39 | KDR | 1.14567598 |
| 40 | FLT3 | 1.12692493 |
| 41 | SMG1 | 1.11953713 |
| 42 | KIT | 1.11840419 |
| 43 | DYRK2 | 1.11144206 |
| 44 | DYRK1B | 1.10509125 |
| 45 | TLK1 | 1.07029097 |
| 46 | TRIM28 | 1.05974345 |
| 47 | PLK4 | 1.05555146 |
| 48 | PIM2 | 1.04669965 |
| 49 | TAOK1 | 1.03775668 |
| 50 | MAP2K2 | 1.03675555 |
| 51 | CSNK1A1L | 1.03018008 |
| 52 | TBK1 | 1.02341899 |
| 53 | ABL2 | 1.02273196 |
| 54 | TGFBR1 | 1.01253196 |
| 55 | MAP4K2 | 0.99695892 |
| 56 | PDK2 | 0.99232413 |
| 57 | MST4 | 0.97723273 |
| 58 | PINK1 | 0.97342149 |
| 59 | BTK | 0.91567782 |
| 60 | PBK | 0.91124827 |
| 61 | RPS6KB2 | 0.88680090 |
| 62 | MAP2K6 | 0.87530376 |
| 63 | IRAK4 | 0.86347589 |
| 64 | DAPK3 | 0.85425979 |
| 65 | NEK6 | 0.84838477 |
| 66 | BRSK1 | 0.84560710 |
| 67 | CASK | 0.84504272 |
| 68 | IRAK2 | 0.84242650 |
| 69 | MAPK13 | 0.83012242 |
| 70 | TESK1 | 0.82336198 |
| 71 | PRKCI | 0.82197123 |
| 72 | CLK1 | 0.82031454 |
| 73 | CSNK1G2 | 0.81499564 |
| 74 | PNCK | 0.81075954 |
| 75 | TAOK2 | 0.79521878 |
| 76 | PRKD2 | 0.78156319 |
| 77 | SYK | 0.77108589 |
| 78 | CSNK1G1 | 0.77036315 |
| 79 | DYRK3 | 0.75129394 |
| 80 | ILK | 0.73895193 |
| 81 | CAMKK1 | 0.72172669 |
| 82 | SIK1 | 0.70653624 |
| 83 | PRKD3 | 0.70014091 |
| 84 | TIE1 | 0.69052189 |
| 85 | MKNK2 | 0.67406425 |
| 86 | IKBKE | 0.66919985 |
| 87 | MAP3K11 | 0.64746870 |
| 88 | SIK2 | 0.64465698 |
| 89 | RPS6KA4 | 0.64343826 |
| 90 | YES1 | 0.63734278 |
| 91 | LRRK2 | 0.62916034 |
| 92 | DAPK1 | 0.62146304 |
| 93 | BLK | 0.61927742 |
| 94 | ZAP70 | 0.61429010 |
| 95 | RPS6KA5 | 0.61425981 |
| 96 | MYLK | 0.60025611 |
| 97 | TXK | 0.59649753 |
| 98 | CAMK2B | 0.58799133 |
| 99 | PKN1 | 0.58689027 |
| 100 | BRAF | 0.58632233 |
| 101 | SCYL2 | 0.58257970 |
| 102 | AURKA | 0.57359292 |
| 103 | FES | 0.56703948 |
| 104 | WNK3 | 0.56643123 |
| 105 | TEC | 0.54799184 |
| 106 | PRPF4B | 0.52626602 |
| 107 | PRKCQ | 0.51987983 |
| 108 | RPS6KA2 | 0.50239299 |
| 109 | PAK1 | 0.50191783 |
| 110 | PAK4 | 0.49528490 |
| 111 | MAP2K3 | 0.47918379 |
| 112 | LYN | 0.47337499 |
| 113 | PRKD1 | 0.46787400 |
| 114 | MAP2K4 | 0.46023480 |
| 115 | CSF1R | 0.45552524 |
| 116 | IKBKB | 0.45537555 |
| 117 | CSNK2A1 | 0.45080240 |
| 118 | ROCK2 | 0.44829510 |
| 119 | CDK11A | 0.43500423 |
| 120 | EPHA2 | 0.43162693 |
| 121 | CDK14 | 0.42854694 |
| 122 | MATK | 0.41584006 |
| 123 | CDK18 | 0.41369137 |
| 124 | MAP3K4 | 0.39784240 |
| 125 | PRKCZ | 0.39697595 |
| 126 | LCK | 0.38179362 |
| 127 | MAPK12 | 0.37675121 |
| 128 | EPHA4 | 0.37190380 |
| 129 | NTRK1 | 0.36760432 |
| 130 | CDK15 | 0.36738127 |
| 131 | CSNK2A2 | 0.36610352 |
| 132 | ITK | 0.36107622 |
| 133 | CAMK2D | 0.35859182 |
| 134 | MINK1 | 0.35821858 |
| 135 | EPHB1 | 0.35332715 |
| 136 | CAMK1 | 0.35228720 |
| 137 | CDC7 | 0.34904229 |
| 138 | PRKCD | 0.33639231 |
| 139 | RPS6KC1 | 0.32864074 |
| 140 | RPS6KL1 | 0.32864074 |
| 141 | MAP3K5 | 0.32384702 |
| 142 | MARK2 | 0.32204041 |
| 143 | CSNK1A1 | 0.32192025 |
| 144 | MAP2K7 | 0.29591692 |
| 145 | CAMK2G | 0.29536255 |
| 146 | MARK3 | 0.29444093 |
| 147 | BMPR2 | 0.29054178 |
| 148 | MAPKAPK2 | 0.28531168 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 5.09748079 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.46327447 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.80619025 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.47663621 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.44777985 |
| 6 | Protein export_Homo sapiens_hsa03060 | 3.13424508 |
| 7 | DNA replication_Homo sapiens_hsa03030 | 2.99600164 |
| 8 | Spliceosome_Homo sapiens_hsa03040 | 2.53547881 |
| 9 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.50552093 |
| 10 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.42966211 |
| 11 | Alzheimers disease_Homo sapiens_hsa05010 | 2.40626167 |
| 12 | Mismatch repair_Homo sapiens_hsa03430 | 2.40262246 |
| 13 | Huntingtons disease_Homo sapiens_hsa05016 | 2.31803966 |
| 14 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.12601672 |
| 15 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 2.07188672 |
| 16 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.03879785 |
| 17 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.84833423 |
| 18 | Homologous recombination_Homo sapiens_hsa03440 | 1.77757233 |
| 19 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.71619764 |
| 20 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.70316884 |
| 21 | Base excision repair_Homo sapiens_hsa03410 | 1.69882855 |
| 22 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.69779674 |
| 23 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.64372196 |
| 24 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.61697271 |
| 25 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.58134887 |
| 26 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.56799795 |
| 27 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.52535155 |
| 28 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.39325681 |
| 29 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.38306912 |
| 30 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.36167170 |
| 31 | Purine metabolism_Homo sapiens_hsa00230 | 1.33428280 |
| 32 | RNA degradation_Homo sapiens_hsa03018 | 1.24817918 |
| 33 | RNA transport_Homo sapiens_hsa03013 | 1.24803544 |
| 34 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.24116801 |
| 35 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.23090207 |
| 36 | Basal transcription factors_Homo sapiens_hsa03022 | 1.21586866 |
| 37 | Sulfur relay system_Homo sapiens_hsa04122 | 1.18467452 |
| 38 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.13974804 |
| 39 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.09194624 |
| 40 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.07814849 |
| 41 | Galactose metabolism_Homo sapiens_hsa00052 | 1.04091276 |
| 42 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.00288711 |
| 43 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.99717477 |
| 44 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.93214000 |
| 45 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.91244269 |
| 46 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.90344127 |
| 47 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.86991382 |
| 48 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.83757053 |
| 49 | Other glycan degradation_Homo sapiens_hsa00511 | 0.83604613 |
| 50 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.82366598 |
| 51 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.82016770 |
| 52 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.75976048 |
| 53 | Lysosome_Homo sapiens_hsa04142 | 0.68994152 |
| 54 | Metabolic pathways_Homo sapiens_hsa01100 | 0.68820715 |
| 55 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.64901326 |
| 56 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.64121300 |
| 57 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.63640353 |
| 58 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.63562086 |
| 59 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.63546883 |
| 60 | Cell cycle_Homo sapiens_hsa04110 | 0.63372868 |
| 61 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.62254436 |
| 62 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.58968242 |
| 63 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.58248741 |
| 64 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.57207800 |
| 65 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.56487384 |
| 66 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.53449988 |
| 67 | Shigellosis_Homo sapiens_hsa05131 | 0.50959422 |
| 68 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.49802280 |
| 69 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.46936646 |
| 70 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.46633384 |
| 71 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.45046711 |
| 72 | Alcoholism_Homo sapiens_hsa05034 | 0.43606345 |
| 73 | Allograft rejection_Homo sapiens_hsa05330 | 0.42033646 |
| 74 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.41021125 |
| 75 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.40890723 |
| 76 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.39605642 |
| 77 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.39185565 |
| 78 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.39037955 |
| 79 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.38877417 |
| 80 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.38169460 |
| 81 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.37884366 |
| 82 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.37235289 |
| 83 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.37076469 |
| 84 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.36092459 |
| 85 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.34947420 |
| 86 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.32861063 |
| 87 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.30776160 |
| 88 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.30293445 |
| 89 | Endocytosis_Homo sapiens_hsa04144 | 0.29868426 |
| 90 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.29474275 |
| 91 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.29332126 |
| 92 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.29244643 |
| 93 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.27869780 |
| 94 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.26077555 |
| 95 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.25431897 |
| 96 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.24603251 |
| 97 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.24262616 |
| 98 | Histidine metabolism_Homo sapiens_hsa00340 | 0.24017378 |
| 99 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.23627499 |
| 100 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.23508137 |
| 101 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.22414146 |
| 102 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.21679424 |
| 103 | Phagosome_Homo sapiens_hsa04145 | 0.20215040 |
| 104 | Salmonella infection_Homo sapiens_hsa05132 | 0.19885250 |
| 105 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.19352173 |
| 106 | Carbon metabolism_Homo sapiens_hsa01200 | 0.17990452 |
| 107 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.17247464 |
| 108 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.17176650 |
| 109 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.15531143 |
| 110 | Phototransduction_Homo sapiens_hsa04744 | 0.15388200 |
| 111 | Peroxisome_Homo sapiens_hsa04146 | 0.14322110 |
| 112 | Thyroid cancer_Homo sapiens_hsa05216 | 0.12596646 |
| 113 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.11734152 |
| 114 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.11495728 |
| 115 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.11133298 |
| 116 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.11028815 |
| 117 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.10244570 |
| 118 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.09072416 |
| 119 | Axon guidance_Homo sapiens_hsa04360 | 0.08600597 |
| 120 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.08310038 |
| 121 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.08287673 |
| 122 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.07362298 |
| 123 | Pertussis_Homo sapiens_hsa05133 | 0.06289542 |
| 124 | Platelet activation_Homo sapiens_hsa04611 | 0.06232715 |
| 125 | Apoptosis_Homo sapiens_hsa04210 | 0.06061621 |

