ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	4.54892630
2	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.15431889
3	DNA methylation involved in gamete generation (GO:0043046)	4.01875527
4	signal peptide processing (GO:0006465)	3.96190134
5	regulation of meiosis I (GO:0060631)	3.74416054
6	platelet dense granule organization (GO:0060155)	3.71429459
7	photoreceptor cell maintenance (GO:0045494)	3.67554583
8	indolalkylamine metabolic process (GO:0006586)	3.60462528
9	synapsis (GO:0007129)	3.60316381
10	reciprocal DNA recombination (GO:0035825)	3.51997340
11	reciprocal meiotic recombination (GO:0007131)	3.51997340
12	indole-containing compound catabolic process (GO:0042436)	3.50446313
13	indolalkylamine catabolic process (GO:0046218)	3.50446313
14	tryptophan catabolic process (GO:0006569)	3.50446313
15	neural tube formation (GO:0001841)	3.33057663
16	kynurenine metabolic process (GO:0070189)	3.32496341
17	L-fucose catabolic process (GO:0042355)	3.32061338
18	fucose catabolic process (GO:0019317)	3.32061338
19	L-fucose metabolic process (GO:0042354)	3.32061338
20	regulation of protein glycosylation (GO:0060049)	3.32023233
21	proteasome assembly (GO:0043248)	3.31466747
22	cellular ketone body metabolic process (GO:0046950)	3.21451951
23	DNA double-strand break processing (GO:0000729)	3.20931675
24	branched-chain amino acid catabolic process (GO:0009083)	3.15113900
25	tryptophan metabolic process (GO:0006568)	3.13973135
26	respiratory chain complex IV assembly (GO:0008535)	3.10740054
27	drug catabolic process (GO:0042737)	3.07777721
28	regulation of hippo signaling (GO:0035330)	3.04192439
29	xenobiotic catabolic process (GO:0042178)	2.99795567
30	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.98242124
31	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.98242124
32	ketone body metabolic process (GO:1902224)	2.96548693
33	male meiosis (GO:0007140)	2.95923909
34	cilium or flagellum-dependent cell motility (GO:0001539)	2.95852391
35	oxidative demethylation (GO:0070989)	2.90523409
36	male meiosis I (GO:0007141)	2.82785363
37	cellular biogenic amine catabolic process (GO:0042402)	2.81191605
38	amine catabolic process (GO:0009310)	2.81191605
39	regulation of triglyceride catabolic process (GO:0010896)	2.79326180
40	gene silencing by RNA (GO:0031047)	2.77884383
41	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.76590542
42	double-strand break repair via homologous recombination (GO:0000724)	2.75621668
43	regulation of gene silencing by RNA (GO:0060966)	2.75195528
44	regulation of posttranscriptional gene silencing (GO:0060147)	2.75195528
45	regulation of gene silencing by miRNA (GO:0060964)	2.75195528
46	response to nitrosative stress (GO:0051409)	2.74738369
47	flavonoid metabolic process (GO:0009812)	2.74573868
48	recombinational repair (GO:0000725)	2.74206773
49	dopamine transport (GO:0015872)	2.73748111
50	aromatic amino acid family catabolic process (GO:0009074)	2.73683566
51	cellular glucuronidation (GO:0052695)	2.71883221
52	single strand break repair (GO:0000012)	2.71763050
53	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.71608709
54	replication fork processing (GO:0031297)	2.71475427
55	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.71142367
56	uronic acid metabolic process (GO:0006063)	2.69969019
57	glucuronate metabolic process (GO:0019585)	2.69969019
58	amino acid salvage (GO:0043102)	2.68425127
59	L-methionine salvage (GO:0071267)	2.68425127
60	L-methionine biosynthetic process (GO:0071265)	2.68425127
61	exogenous drug catabolic process (GO:0042738)	2.67956431
62	axoneme assembly (GO:0035082)	2.65781084
63	bile acid biosynthetic process (GO:0006699)	2.65775624
64	cytochrome complex assembly (GO:0017004)	2.65618118
65	regulation of memory T cell differentiation (GO:0043380)	2.63921430
66	monoubiquitinated protein deubiquitination (GO:0035520)	2.62195026
67	DNA integration (GO:0015074)	2.61155852
68	branched-chain amino acid metabolic process (GO:0009081)	2.59259141
69	anterograde synaptic vesicle transport (GO:0048490)	2.58260908
70	aromatic amino acid family metabolic process (GO:0009072)	2.57808668
71	drug metabolic process (GO:0017144)	2.57048747
72	aspartate family amino acid catabolic process (GO:0009068)	2.56855427
73	methionine metabolic process (GO:0006555)	2.56806702
74	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.55510815
75	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.55510815
76	mannosylation (GO:0097502)	2.55193299
77	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.55062546
78	nucleotide transmembrane transport (GO:1901679)	2.54913803
79	methionine biosynthetic process (GO:0009086)	2.53609614
80	meiotic chromosome segregation (GO:0045132)	2.51641512
81	benzene-containing compound metabolic process (GO:0042537)	2.51255040
82	prenylation (GO:0097354)	2.50977411
83	protein prenylation (GO:0018342)	2.50977411
84	indole-containing compound metabolic process (GO:0042430)	2.49435831
85	water-soluble vitamin biosynthetic process (GO:0042364)	2.48039982
86	cell wall macromolecule catabolic process (GO:0016998)	2.47082236
87	pseudouridine synthesis (GO:0001522)	2.45915352
88	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.43268657
89	detection of light stimulus involved in sensory perception (GO:0050962)	2.42250654
90	detection of light stimulus involved in visual perception (GO:0050908)	2.42250654
91	sphingoid metabolic process (GO:0046519)	2.41331964
92	DNA catabolic process, exonucleolytic (GO:0000738)	2.41265402
93	preassembly of GPI anchor in ER membrane (GO:0016254)	2.40998702
94	regulation of cilium movement (GO:0003352)	2.40973544
95	DNA deamination (GO:0045006)	2.39673354
96	protein K11-linked ubiquitination (GO:0070979)	2.38600736
97	retinal cone cell development (GO:0046549)	2.33734925
98	interleukin-6-mediated signaling pathway (GO:0070102)	2.33128977
99	sulfur amino acid biosynthetic process (GO:0000097)	2.33088707
100	auditory receptor cell stereocilium organization (GO:0060088)	2.32061914

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.22151226
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.18342114
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.69301844
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.64231801
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.47342611
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.45269260
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.43102972
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.31241958
9	P300_19829295_ChIP-Seq_ESCs_Human	2.20264901
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.19961838
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.13418696
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.05795847
13	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.02218861
14	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.01097559
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.95399480
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.94185341
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.91432207
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.90952712
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.90000072
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.89722176
21	EWS_26573619_Chip-Seq_HEK293_Human	1.89418577
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.87668252
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.87176198
24	FUS_26573619_Chip-Seq_HEK293_Human	1.76696717
25	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.72002505
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.65466058
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.62876371
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60372835
29	STAT3_23295773_ChIP-Seq_U87_Human	1.58897188
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.56990612
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.55224979
32	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.52691018
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.52145221
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52145221
35	TCF4_22108803_ChIP-Seq_LS180_Human	1.50045869
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49627652
37	NANOG_19829295_ChIP-Seq_ESCs_Human	1.49059996
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.49059996
39	CDX2_22108803_ChIP-Seq_LS180_Human	1.48777699
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46447031
41	SMAD4_21799915_ChIP-Seq_A2780_Human	1.44686434
42	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.42960791
43	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.40710053
44	* FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.38964607
45	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.36694123
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.35449018
47	TCF4_23295773_ChIP-Seq_U87_Human	1.33022777
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.32662363
49	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32123785
50	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32123785
51	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31038944
52	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30833329
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.29492954
54	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.27609397
55	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.27384801
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25825077
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25614712
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25614712
59	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.24076164
60	AR_20517297_ChIP-Seq_VCAP_Human	1.23649194
61	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.21176859
62	AR_25329375_ChIP-Seq_VCAP_Human	1.20245916
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19785537
64	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.19133018
65	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.18674325
66	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.18387459
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18108467
68	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17671253
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16123693
70	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16044515
71	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15410366
72	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.15201503
73	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.14689622
74	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13456865
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11550753
76	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10717085
77	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09321726
78	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.08054031
79	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.07119077
80	* FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.05776751
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05668482
82	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.05652942
83	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.03962478
84	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.03532750
85	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02613680
86	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.01744429
87	VDR_23849224_ChIP-Seq_CD4+_Human	1.01708911
88	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.01607228
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00630449
90	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.00538442
91	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.99579725
92	GATA3_26560356_Chip-Seq_TH2_Human	0.99115410
93	PHF8_20622853_ChIP-Seq_HELA_Human	0.97261478
94	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.97180200
95	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.96335275
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96040312
97	NCOR_22424771_ChIP-Seq_293T_Human	0.94867873
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94175552
99	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.94124713
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.93661881

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.97556391
2	MP0008877_abnormal_DNA_methylation	3.86868034
3	MP0005085_abnormal_gallbladder_physiolo	3.40963871
4	MP0004147_increased_porphyrin_level	2.65630383
5	MP0003718_maternal_effect	2.58981001
6	MP0008057_abnormal_DNA_replication	2.56529527
7	MP0005365_abnormal_bile_salt	2.51852908
8	MP0002138_abnormal_hepatobiliary_system	2.46771477
9	MP0000569_abnormal_digit_pigmentation	2.25779741
10	MP0000372_irregular_coat_pigmentation	2.21772634
11	MP0003136_yellow_coat_color	2.15204059
12	MP0008875_abnormal_xenobiotic_pharmacok	2.12085371
13	MP0005551_abnormal_eye_electrophysiolog	2.05361653
14	MP0005360_urolithiasis	2.01816745
15	MP0005670_abnormal_white_adipose	2.01778460
16	MP0002102_abnormal_ear_morphology	1.99845135
17	MP0008058_abnormal_DNA_repair	1.98878629
18	MP0002139_abnormal_hepatobiliary_system	1.96666281
19	MP0002254_reproductive_system_inflammat	1.95382034
20	MP0003252_abnormal_bile_duct	1.95213865
21	MP0000427_abnormal_hair_cycle	1.92126650
22	MP0009697_abnormal_copulation	1.76552936
23	MP0003806_abnormal_nucleotide_metabolis	1.75976752
24	MP0003646_muscle_fatigue	1.75463721
25	MP0001485_abnormal_pinna_reflex	1.75253749
26	MP0001764_abnormal_homeostasis	1.75166442
27	MP0005174_abnormal_tail_pigmentation	1.64133374
28	MP0005395_other_phenotype	1.60490937
29	MP0005253_abnormal_eye_physiology	1.53750044
30	MP0000015_abnormal_ear_pigmentation	1.52459010
31	MP0003950_abnormal_plasma_membrane	1.47098691
32	MP0003878_abnormal_ear_physiology	1.44907812
33	MP0005377_hearing/vestibular/ear_phenot	1.44907812
34	MP0005075_abnormal_melanosome_morpholog	1.43817075
35	MP0002090_abnormal_vision	1.43045136
36	MP0003724_increased_susceptibility_to	1.41251722
37	MP0008872_abnormal_physiological_respon	1.37199401
38	MP0010094_abnormal_chromosome_stability	1.33544578
39	MP0001501_abnormal_sleep_pattern	1.32814660
40	MP0002736_abnormal_nociception_after	1.31985307
41	MP0002837_dystrophic_cardiac_calcinosis	1.30045684
42	MP0002876_abnormal_thyroid_physiology	1.29394590
43	MP0005332_abnormal_amino_acid	1.28200996
44	MP0001929_abnormal_gametogenesis	1.25459791
45	MP0005084_abnormal_gallbladder_morpholo	1.24961411
46	MP0005410_abnormal_fertilization	1.21463297
47	MP0005647_abnormal_sex_gland	1.19332980
48	MP0006072_abnormal_retinal_apoptosis	1.17567938
49	MP0002132_abnormal_respiratory_system	1.17205142
50	MP0001324_abnormal_eye_pigmentation	1.16479777
51	MP0003890_abnormal_embryonic-extraembry	1.15346021
52	MP0006035_abnormal_mitochondrial_morpho	1.14532351
53	MP0003011_delayed_dark_adaptation	1.13311000
54	MP0004957_abnormal_blastocyst_morpholog	1.12426228
55	MP0001666_abnormal_nutrient_absorption	1.11965395
56	MP0003191_abnormal_cellular_cholesterol	1.11847670
57	MP0006082_CNS_inflammation	1.11673886
58	MP0003693_abnormal_embryo_hatching	1.10215866
59	MP0000371_diluted_coat_color	1.08249406
60	MP0006292_abnormal_olfactory_placode	1.07631724
61	MP0003186_abnormal_redox_activity	1.06313852
62	MP0004019_abnormal_vitamin_homeostasis	1.04826479
63	MP0003656_abnormal_erythrocyte_physiolo	1.04104377
64	MP0003787_abnormal_imprinting	1.03682128
65	MP0000383_abnormal_hair_follicle	1.03141097
66	MP0002168_other_aberrant_phenotype	1.00761614
67	MP0001986_abnormal_taste_sensitivity	1.00618043
68	MP0002938_white_spotting	1.00471661
69	MP0002095_abnormal_skin_pigmentation	0.99768236
70	MP0003943_abnormal_hepatobiliary_system	0.98282416
71	MP0003698_abnormal_male_reproductive	0.97610687
72	MP0001968_abnormal_touch/_nociception	0.95328858
73	MP0005408_hypopigmentation	0.94240689
74	MP0010329_abnormal_lipoprotein_level	0.94110239
75	MP0005636_abnormal_mineral_homeostasis	0.93754787
76	MP0000653_abnormal_sex_gland	0.91787484
77	MP0003786_premature_aging	0.90354182
78	MP0002210_abnormal_sex_determination	0.89743720
79	MP0005310_abnormal_salivary_gland	0.89613815
80	MP0005464_abnormal_platelet_physiology	0.87627421
81	MP0000358_abnormal_cell_content/	0.86863427
82	MP0009046_muscle_twitch	0.85437169
83	MP0006036_abnormal_mitochondrial_physio	0.84853178
84	MP0004215_abnormal_myocardial_fiber	0.84823883
85	MP0001529_abnormal_vocalization	0.82835754
86	MP0001145_abnormal_male_reproductive	0.82691801
87	MP0003183_abnormal_peptide_metabolism	0.82595153
88	MP0004264_abnormal_extraembryonic_tissu	0.81139785
89	MP0009764_decreased_sensitivity_to	0.78805770
90	MP0010678_abnormal_skin_adnexa	0.75633785
91	MP0003045_fibrosis	0.75047464
92	MP0005083_abnormal_biliary_tract	0.74214566
93	MP0005376_homeostasis/metabolism_phenot	0.74075570
94	MP0003111_abnormal_nucleus_morphology	0.72940159
95	MP0002148_abnormal_hypersensitivity_rea	0.72814974
96	MP0005319_abnormal_enzyme/_coenzyme	0.72723161
97	MP0005266_abnormal_metabolism	0.71484165
98	MP0002653_abnormal_ependyma_morphology	0.71106630
99	MP0006054_spinal_hemorrhage	0.68787578
100	MP0000647_abnormal_sebaceous_gland	0.68603712

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.01112763
2	Pancreatic fibrosis (HP:0100732)	3.47980730
3	True hermaphroditism (HP:0010459)	3.32927388
4	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.15031069
5	Molar tooth sign on MRI (HP:0002419)	2.96416285
6	Abnormality of midbrain morphology (HP:0002418)	2.96416285
7	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.73526094
8	Abnormality of alanine metabolism (HP:0010916)	2.73526094
9	Hyperalaninemia (HP:0003348)	2.73526094
10	Gaze-evoked nystagmus (HP:0000640)	2.69417959
11	Medial flaring of the eyebrow (HP:0010747)	2.66154513
12	Hyperglycinemia (HP:0002154)	2.63798562
13	Nephronophthisis (HP:0000090)	2.62286062
14	Hyperglycinuria (HP:0003108)	2.60101476
15	Type I transferrin isoform profile (HP:0003642)	2.55221507
16	Abnormality of the renal cortex (HP:0011035)	2.54370546
17	Albinism (HP:0001022)	2.53679304
18	Abolished electroretinogram (ERG) (HP:0000550)	2.53029820
19	Short tibia (HP:0005736)	2.51415936
20	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.51253766
21	Attenuation of retinal blood vessels (HP:0007843)	2.47804562
22	Abnormality of serine family amino acid metabolism (HP:0010894)	2.47415324
23	Abnormality of glycine metabolism (HP:0010895)	2.47415324
24	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.45812233
25	Congenital stationary night blindness (HP:0007642)	2.38864586
26	Abnormality of the renal medulla (HP:0100957)	2.38501278
27	Abnormality of the labia minora (HP:0012880)	2.34187489
28	Methylmalonic acidemia (HP:0002912)	2.33500321
29	Stomach cancer (HP:0012126)	2.32457805
30	Abnormality of serum amino acid levels (HP:0003112)	2.32248915
31	Amelogenesis imperfecta (HP:0000705)	2.30036060
32	Methylmalonic aciduria (HP:0012120)	2.28063302
33	Abnormality of methionine metabolism (HP:0010901)	2.27260554
34	Bile duct proliferation (HP:0001408)	2.27136376
35	Abnormal biliary tract physiology (HP:0012439)	2.27136376
36	Cystic liver disease (HP:0006706)	2.26036990
37	Congenital hepatic fibrosis (HP:0002612)	2.24922855
38	Pancreatic islet-cell hyperplasia (HP:0004510)	2.21229971
39	Intrahepatic cholestasis (HP:0001406)	2.16285166
40	Congenital sensorineural hearing impairment (HP:0008527)	2.15748002
41	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.15161724
42	Abnormal protein N-linked glycosylation (HP:0012347)	2.15161724
43	Abnormal protein glycosylation (HP:0012346)	2.15161724
44	Abnormal glycosylation (HP:0012345)	2.15161724
45	Congenital primary aphakia (HP:0007707)	2.13798582
46	Chronic hepatic failure (HP:0100626)	2.13720649
47	Oculomotor apraxia (HP:0000657)	2.11226054
48	Azoospermia (HP:0000027)	2.08913237
49	Abnormality of macular pigmentation (HP:0008002)	2.06931158
50	Median cleft lip (HP:0000161)	2.06086332
51	Renal cortical cysts (HP:0000803)	2.04108028
52	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.03087193
53	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.02869469
54	Decreased central vision (HP:0007663)	1.99874299
55	Enlarged kidneys (HP:0000105)	1.99803730
56	Postaxial foot polydactyly (HP:0001830)	1.98944411
57	Severe visual impairment (HP:0001141)	1.97207659
58	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.96483812
59	Central scotoma (HP:0000603)	1.95323688
60	Gait imbalance (HP:0002141)	1.94733576
61	Facial diplegia (HP:0001349)	1.93536903
62	Abnormality of vitamin B metabolism (HP:0004340)	1.89110928
63	Anencephaly (HP:0002323)	1.88660439
64	Genital tract atresia (HP:0001827)	1.86793982
65	Bifid tongue (HP:0010297)	1.85682922
66	Nephrogenic diabetes insipidus (HP:0009806)	1.85613698
67	Ileus (HP:0002595)	1.84641155
68	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.81675855
69	Fair hair (HP:0002286)	1.80578896
70	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.80377713
71	Abnormal respiratory motile cilium physiology (HP:0012261)	1.79469599
72	Male pseudohermaphroditism (HP:0000037)	1.78525283
73	Intestinal atresia (HP:0011100)	1.76621464
74	Abnormality of chromosome stability (HP:0003220)	1.76266078
75	Abnormal spermatogenesis (HP:0008669)	1.76186918
76	Vaginal atresia (HP:0000148)	1.75711072
77	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.75603853
78	Retinitis pigmentosa (HP:0000510)	1.75521637
79	Progressive inability to walk (HP:0002505)	1.75487417
80	Bony spicule pigmentary retinopathy (HP:0007737)	1.73459046
81	Stomatitis (HP:0010280)	1.73456467
82	Chronic bronchitis (HP:0004469)	1.72946337
83	Preaxial hand polydactyly (HP:0001177)	1.72943310
84	Reduced antithrombin III activity (HP:0001976)	1.72705410
85	Vacuolated lymphocytes (HP:0001922)	1.72410500
86	Asplenia (HP:0001746)	1.72117820
87	Constricted visual fields (HP:0001133)	1.71861890
88	Optic neuritis (HP:0100653)	1.71220840
89	Retrobulbar optic neuritis (HP:0100654)	1.71220840
90	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.69763695
91	Sclerocornea (HP:0000647)	1.69064095
92	Small hand (HP:0200055)	1.66933115
93	Abnormality of the preputium (HP:0100587)	1.66169434
94	Ketosis (HP:0001946)	1.65789365
95	Sloping forehead (HP:0000340)	1.65766231
96	Homocystinuria (HP:0002156)	1.65668438
97	Abnormality of homocysteine metabolism (HP:0010919)	1.65668438
98	Abnormal ciliary motility (HP:0012262)	1.64806560
99	Supernumerary spleens (HP:0009799)	1.63859173
100	Hypochromic microcytic anemia (HP:0004840)	1.63513246

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.96483718
2	ACVR1B	3.63124515
3	BMPR1B	3.38814312
4	MAP4K2	2.75466567
5	MST4	2.54050153
6	NUAK1	2.50045582
7	ZAK	2.42266891
8	WNK3	2.28389168
9	TRIM28	2.21449395
10	EIF2AK3	2.14234508
11	INSRR	1.96689574
12	BUB1	1.84988357
13	STK38L	1.83119434
14	STK3	1.79154393
15	ADRBK2	1.73004106
16	PDK2	1.66355375
17	GRK1	1.61115800
18	FER	1.59209743
19	LATS1	1.43207607
20	PBK	1.43002928
21	OXSR1	1.41854521
22	MKNK2	1.40843343
23	SIK3	1.37593145
24	PIK3CG	1.34784979
25	TNIK	1.32040064
26	PINK1	1.31322094
27	MET	1.25654668
28	PLK4	1.24292489
29	BRSK2	1.23348411
30	BCR	1.23163519
31	TAF1	1.19587349
32	MAP3K12	1.18808819
33	ERBB3	1.18291471
34	EIF2AK1	1.16868863
35	TEC	1.09030352
36	PAK3	1.07611950
37	PLK3	1.04366113
38	TNK2	1.02976768
39	TTK	1.00474957
40	STK39	1.00264459
41	BCKDK	0.98757548
42	MKNK1	0.98350033
43	TAOK3	0.98274637
44	PRKCE	0.92588225
45	STK16	0.92472131
46	CDK19	0.91860086
47	MAPK13	0.89549472
48	IRAK1	0.89249033
49	TGFBR1	0.85966745
50	NLK	0.85274300
51	MST1R	0.85221331
52	MAP3K4	0.84403069
53	PTK2B	0.81994499
54	PLK1	0.72580084
55	SRPK1	0.72401508
56	MAP3K2	0.69906331
57	CSNK1G1	0.69684085
58	STK38	0.67702717
59	PLK2	0.65464879
60	BMPR2	0.64538729
61	NME1	0.62527037
62	CSNK1G2	0.59998417
63	STK4	0.59422260
64	EIF2AK2	0.57196537
65	DYRK3	0.57182449
66	AKT3	0.57006815
67	YES1	0.56541404
68	LMTK2	0.56205876
69	ADRBK1	0.54709862
70	VRK1	0.49504599
71	NEK1	0.47146617
72	MARK3	0.47143302
73	CDC7	0.47091049
74	CSNK1G3	0.46896422
75	VRK2	0.45886019
76	CSNK1A1L	0.44573895
77	STK24	0.44166105
78	DAPK2	0.43615752
79	STK10	0.42132759
80	MUSK	0.40544444
81	TXK	0.38129286
82	FES	0.37592629
83	CSF1R	0.37162512
84	GRK7	0.36682438
85	WEE1	0.36319649
86	NTRK3	0.35383464
87	FGR	0.35282245
88	PRKCQ	0.35112316
89	MATK	0.34046724
90	PRKCI	0.33219376
91	RAF1	0.32453352
92	NEK2	0.31628827
93	PRKCG	0.31603832
94	EGFR	0.31033359
95	IGF1R	0.30713461
96	MAP2K7	0.30231367
97	TSSK6	0.28560781
98	ATM	0.28356056
99	PKN1	0.27919671
100	CASK	0.27896234

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.72077794
2	Homologous recombination_Homo sapiens_hsa03440	2.65024671
3	Butanoate metabolism_Homo sapiens_hsa00650	2.54849167
4	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.42443980
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.42004850
6	Caffeine metabolism_Homo sapiens_hsa00232	2.35050528
7	Propanoate metabolism_Homo sapiens_hsa00640	2.22955702
8	Proteasome_Homo sapiens_hsa03050	2.21303572
9	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.12071516
10	Tryptophan metabolism_Homo sapiens_hsa00380	2.04023219
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.96538751
12	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.94147322
13	Retinol metabolism_Homo sapiens_hsa00830	1.91800946
14	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.84698199
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.84420988
16	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.83995445
17	Chemical carcinogenesis_Homo sapiens_hsa05204	1.79988113
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.79937392
19	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.76591635
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.71799271
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.69341325
22	Peroxisome_Homo sapiens_hsa04146	1.67250993
23	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.64169451
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.59981421
25	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.55462061
26	Fatty acid elongation_Homo sapiens_hsa00062	1.55286918
27	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.52900946
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.51339484
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.50816686
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.42664356
31	beta-Alanine metabolism_Homo sapiens_hsa00410	1.42537693
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.36993031
33	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.36105794
34	Fatty acid degradation_Homo sapiens_hsa00071	1.34399661
35	Base excision repair_Homo sapiens_hsa03410	1.32921472
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.32596257
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.31570075
38	Phototransduction_Homo sapiens_hsa04744	1.31477003
39	ABC transporters_Homo sapiens_hsa02010	1.28994732
40	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.28603835
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.25787677
42	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.24789153
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.22763952
44	Mismatch repair_Homo sapiens_hsa03430	1.21986865
45	Fatty acid metabolism_Homo sapiens_hsa01212	1.19511647
46	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.18786794
47	Basal transcription factors_Homo sapiens_hsa03022	1.16924143
48	Histidine metabolism_Homo sapiens_hsa00340	1.16912344
49	Sphingolipid metabolism_Homo sapiens_hsa00600	1.11024711
50	Protein export_Homo sapiens_hsa03060	1.10694666
51	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.10534376
52	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.08543365
53	Sulfur metabolism_Homo sapiens_hsa00920	1.07308358
54	One carbon pool by folate_Homo sapiens_hsa00670	1.06813821
55	Selenocompound metabolism_Homo sapiens_hsa00450	1.06269114
56	Ether lipid metabolism_Homo sapiens_hsa00565	1.04211523
57	Fat digestion and absorption_Homo sapiens_hsa04975	1.03273364
58	Glutathione metabolism_Homo sapiens_hsa00480	1.02338251
59	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.00839791
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.92252983
61	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88133126
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.83751966
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80273574
64	Metabolic pathways_Homo sapiens_hsa01100	0.79848212
65	RNA polymerase_Homo sapiens_hsa03020	0.79095593
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.77202844
67	Arginine and proline metabolism_Homo sapiens_hsa00330	0.72811529
68	Steroid biosynthesis_Homo sapiens_hsa00100	0.69977385
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.69305585
70	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.68628629
71	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.68012555
72	RNA degradation_Homo sapiens_hsa03018	0.66209352
73	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.64420544
74	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.62020485
75	Pyrimidine metabolism_Homo sapiens_hsa00240	0.60165535
76	Folate biosynthesis_Homo sapiens_hsa00790	0.59890542
77	Circadian rhythm_Homo sapiens_hsa04710	0.59339483
78	Purine metabolism_Homo sapiens_hsa00230	0.59295433
79	Tyrosine metabolism_Homo sapiens_hsa00350	0.59039322
80	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.58766312
81	Olfactory transduction_Homo sapiens_hsa04740	0.57730971
82	Complement and coagulation cascades_Homo sapiens_hsa04610	0.57069551
83	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.54283230
84	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53467054
85	Mineral absorption_Homo sapiens_hsa04978	0.49631747
86	Regulation of autophagy_Homo sapiens_hsa04140	0.49158388
87	DNA replication_Homo sapiens_hsa03030	0.47582024
88	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.45723599
89	RNA transport_Homo sapiens_hsa03013	0.45431717
90	Nucleotide excision repair_Homo sapiens_hsa03420	0.41556318
91	Arginine biosynthesis_Homo sapiens_hsa00220	0.40670302
92	Legionellosis_Homo sapiens_hsa05134	0.39905207
93	Phenylalanine metabolism_Homo sapiens_hsa00360	0.39570144
94	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.39186126
95	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.38385489
96	PPAR signaling pathway_Homo sapiens_hsa03320	0.37867129
97	Taste transduction_Homo sapiens_hsa04742	0.37487001
98	Oocyte meiosis_Homo sapiens_hsa04114	0.37081935
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.32831401
100	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.31076237

NUDT16P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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