NUDT17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)7.97815757
2regulation of T-helper 1 cell differentiation (GO:0045625)6.32026413
3ribosomal small subunit biogenesis (GO:0042274)6.12277081
4regulation of dendritic cell antigen processing and presentation (GO:0002604)6.05933500
5viral transcription (GO:0019083)6.00455519
6positive regulation of natural killer cell differentiation (GO:0032825)5.84139786
7translational termination (GO:0006415)5.80801167
8maturation of SSU-rRNA (GO:0030490)5.79368738
9regulation of activation of Janus kinase activity (GO:0010533)5.51300080
10regulation of hypersensitivity (GO:0002883)5.51019634
11regulation of T-helper 2 cell differentiation (GO:0045628)5.39647640
12regulation of RIG-I signaling pathway (GO:0039535)5.23639078
13myeloid dendritic cell differentiation (GO:0043011)5.17051324
14positive regulation of T-helper cell differentiation (GO:0045624)5.12891238
15T-helper 1 type immune response (GO:0042088)5.10229664
16negative thymic T cell selection (GO:0045060)5.03878474
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.95341362
18ribosomal small subunit assembly (GO:0000028)4.95003244
19establishment of protein localization to mitochondrial membrane (GO:0090151)4.94922226
20positive regulation of antigen processing and presentation (GO:0002579)4.93980042
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.91409175
22cotranslational protein targeting to membrane (GO:0006613)4.91151840
23chaperone-mediated protein transport (GO:0072321)4.86598253
24positive regulation of interleukin-12 production (GO:0032735)4.86050057
25neutrophil activation involved in immune response (GO:0002283)4.85955303
26translational elongation (GO:0006414)4.83961928
27protein targeting to ER (GO:0045047)4.83597958
28positive regulation of protein homooligomerization (GO:0032464)4.78279435
29CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.74574672
30T-helper cell differentiation (GO:0042093)4.74574672
31protein complex biogenesis (GO:0070271)4.73743428
32neutrophil activation (GO:0042119)4.73733218
33natural killer cell mediated cytotoxicity (GO:0042267)4.72519554
34natural killer cell mediated immunity (GO:0002228)4.72519554
35negative T cell selection (GO:0043383)4.64973084
36ATP synthesis coupled proton transport (GO:0015986)4.62024647
37energy coupled proton transport, down electrochemical gradient (GO:0015985)4.62024647
38establishment of protein localization to endoplasmic reticulum (GO:0072599)4.61786198
39protein localization to endoplasmic reticulum (GO:0070972)4.61642017
40myeloid dendritic cell activation (GO:0001773)4.59646700
41positive regulation of type 2 immune response (GO:0002830)4.57359836
42behavioral response to nicotine (GO:0035095)4.55828269
43regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.54280235
44positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.50398773
45viral life cycle (GO:0019058)4.49369810
46granulocyte activation (GO:0036230)4.47964911
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.42590909
48mitochondrial respiratory chain complex I assembly (GO:0032981)4.42590909
49NADH dehydrogenase complex assembly (GO:0010257)4.42590909
50regulation of T cell tolerance induction (GO:0002664)4.40086711
51antigen processing and presentation of endogenous antigen (GO:0019883)4.39262702
52mitochondrial respiratory chain complex assembly (GO:0033108)4.36611830
53response to prostaglandin E (GO:0034695)4.36264826
54regulation of antigen processing and presentation (GO:0002577)4.36235114
55cellular protein complex disassembly (GO:0043624)4.34230491
56regulation of immunoglobulin secretion (GO:0051023)4.31597790
57regulation of memory T cell differentiation (GO:0043380)4.30359071
58mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.27540566
59RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.15035655
60tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.15035655
61dendritic cell differentiation (GO:0097028)4.14466990
62regulation of natural killer cell differentiation (GO:0032823)4.14112964
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.12935385
64alpha-beta T cell differentiation involved in immune response (GO:0002293)4.10875702
65alpha-beta T cell activation involved in immune response (GO:0002287)4.10875702
66T cell differentiation involved in immune response (GO:0002292)4.10875702
67positive regulation of alpha-beta T cell proliferation (GO:0046641)4.07839341
68regulation of T-helper cell differentiation (GO:0045622)4.03256436
69positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.02361245
70ribosomal large subunit biogenesis (GO:0042273)3.98814507
71positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.98008318
72positive regulation of T cell cytokine production (GO:0002726)3.95427470
73positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.94029500
74electron transport chain (GO:0022900)3.93363442
75respiratory electron transport chain (GO:0022904)3.92126162
76regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.90314453
77dendritic cell migration (GO:0036336)3.89866523
78dendritic cell chemotaxis (GO:0002407)3.88946326
79growth hormone receptor signaling pathway (GO:0060396)3.87105829
80cytochrome complex assembly (GO:0017004)3.86118243
81translational initiation (GO:0006413)3.84254353
82regulation of alpha-beta T cell proliferation (GO:0046640)3.83877941
83regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.81629656
84protein-cofactor linkage (GO:0018065)3.80858080
85positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.80783132
86protein complex disassembly (GO:0043241)3.80413139
87interferon-gamma secretion (GO:0072643)3.79301239
88respiratory chain complex IV assembly (GO:0008535)3.79039928
89type I interferon signaling pathway (GO:0060337)3.73373644
90cellular response to type I interferon (GO:0071357)3.73373644
91regulation of mitochondrial translation (GO:0070129)3.69130174
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.68797219
93antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.68797219
94response to type I interferon (GO:0034340)3.64810366
95pseudouridine synthesis (GO:0001522)3.64454789
96protein neddylation (GO:0045116)3.63955051
97T cell selection (GO:0045058)3.63937435
98response to muramyl dipeptide (GO:0032495)3.62054610
99positive regulation of monocyte chemotaxis (GO:0090026)3.60941243
100cellular response to zinc ion (GO:0071294)3.60250868
101transcription elongation from RNA polymerase III promoter (GO:0006385)3.58229471
102termination of RNA polymerase III transcription (GO:0006386)3.58229471
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.55959017
104positive regulation of protein oligomerization (GO:0032461)3.55912524
105regulation of interleukin-12 biosynthetic process (GO:0045075)3.54324388
106macromolecular complex disassembly (GO:0032984)3.52108817
107regulation of T-helper 1 type immune response (GO:0002825)3.51665285
108regulation of interleukin-12 production (GO:0032655)3.51391131
109translation (GO:0006412)3.51380668
110regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.49608726
111CD4-positive, alpha-beta T cell activation (GO:0035710)3.46626955
112positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.44140835
113water-soluble vitamin biosynthetic process (GO:0042364)3.43568687
114positive regulation of interleukin-2 production (GO:0032743)3.43424824
115cellular component biogenesis (GO:0044085)3.42902809
116resolution of meiotic recombination intermediates (GO:0000712)3.42888047
117pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.40957535
118long-chain fatty acid biosynthetic process (GO:0042759)3.40322161
119thymic T cell selection (GO:0045061)3.39878089
120T cell activation involved in immune response (GO:0002286)3.38875745
121monocyte chemotaxis (GO:0002548)3.38083398
122positive regulation of humoral immune response (GO:0002922)3.37479386
123positive regulation of activated T cell proliferation (GO:0042104)3.36594705
124positive regulation of pseudopodium assembly (GO:0031274)3.36211553
125negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.36006351
126rRNA modification (GO:0000154)3.35615182
127regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.35134576
128platelet dense granule organization (GO:0060155)3.33226151
129positive regulation of T-helper 1 type immune response (GO:0002827)3.32694529
130regulation of tolerance induction (GO:0002643)3.32379518
131eosinophil chemotaxis (GO:0048245)3.31174794
132leukocyte mediated cytotoxicity (GO:0001909)3.31151811
133response to pheromone (GO:0019236)3.30632514
134cellular response to growth hormone stimulus (GO:0071378)3.27127535
135tRNA processing (GO:0008033)3.27099091
136substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.25332382
137substrate-independent telencephalic tangential migration (GO:0021826)3.25332382
138interferon-gamma-mediated signaling pathway (GO:0060333)3.22275752
139exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22194591
140peptidyl-histidine modification (GO:0018202)3.21079782
141nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20627656
142base-excision repair, AP site formation (GO:0006285)3.20385716
143aggressive behavior (GO:0002118)3.18663429
144male meiosis I (GO:0007141)3.17089875
145response to prostaglandin (GO:0034694)3.16390437
146protein targeting to membrane (GO:0006612)3.16144022
147nuclear-transcribed mRNA catabolic process (GO:0000956)3.16091940
148ribonucleoprotein complex biogenesis (GO:0022613)3.15067746
149negative regulation of interleukin-17 production (GO:0032700)3.11306587
150lymphocyte migration (GO:0072676)3.10378680
151lymphocyte mediated immunity (GO:0002449)3.10072958
152negative regulation of necroptotic process (GO:0060546)3.09487282
153intracellular protein transmembrane import (GO:0044743)3.06538595
154CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.06162388
155alpha-beta T cell activation (GO:0046631)3.04750415
156negative regulation of viral genome replication (GO:0045071)3.04707153
157positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.04541026
158positive regulation of interleukin-17 production (GO:0032740)3.03259319
159desmosome organization (GO:0002934)3.02751827
160regulation of necroptotic process (GO:0060544)3.01789516
161pyrimidine nucleotide catabolic process (GO:0006244)3.00914184
162positive regulation of T cell apoptotic process (GO:0070234)3.00823705
163positive regulation of glycoprotein biosynthetic process (GO:0010560)2.99086074
164regulation of MHC class I biosynthetic process (GO:0045343)2.99082669
165striated muscle atrophy (GO:0014891)2.98516616
166mRNA catabolic process (GO:0006402)2.98160744
167hydrogen ion transmembrane transport (GO:1902600)2.92817486
168protein targeting to mitochondrion (GO:0006626)2.86662236
169meiosis I (GO:0007127)2.85695657
170meiotic chromosome segregation (GO:0045132)2.85120057
171negative regulation of response to food (GO:0032096)2.83532703
172negative regulation of appetite (GO:0032099)2.83532703
173DNA deamination (GO:0045006)2.83371808
174nephron tubule morphogenesis (GO:0072078)2.83243714
175nephron epithelium morphogenesis (GO:0072088)2.83243714
176rRNA processing (GO:0006364)2.80881982
177tRNA modification (GO:0006400)2.80612004
178preassembly of GPI anchor in ER membrane (GO:0016254)2.79120806
179rRNA methylation (GO:0031167)2.78076124
180RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.76917513
181nonmotile primary cilium assembly (GO:0035058)2.75456213
182establishment of protein localization to mitochondrion (GO:0072655)2.75423881
183RNA catabolic process (GO:0006401)2.74279533
184cellular response to ATP (GO:0071318)2.73422037
185positive regulation of gastrulation (GO:2000543)2.72738419
186ATP biosynthetic process (GO:0006754)2.72204825
187rRNA metabolic process (GO:0016072)2.69438504
188tRNA metabolic process (GO:0006399)2.69260597
189pattern specification involved in kidney development (GO:0061004)2.69101234
190mannosylation (GO:0097502)2.65630705
191protein localization to mitochondrion (GO:0070585)2.64668432
192proton transport (GO:0015992)2.62056514
193axoneme assembly (GO:0035082)2.61661971
194purine nucleoside triphosphate biosynthetic process (GO:0009145)2.61538828
195ubiquinone biosynthetic process (GO:0006744)2.61473177
196purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.60163109
197GPI anchor biosynthetic process (GO:0006506)2.59740918
198hydrogen transport (GO:0006818)2.59524855
199deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.59025625
200deoxyribonucleotide catabolic process (GO:0009264)2.58964812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.40142548
2IRF8_22096565_ChIP-ChIP_GC-B_Human7.34677240
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.69210278
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.66134002
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.86424760
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.51079128
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.35267982
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.12290596
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.06024609
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.00502361
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.99416523
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.59287315
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.45582016
14EST1_17652178_ChIP-ChIP_JURKAT_Human3.36775888
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.32990974
16ETS1_20019798_ChIP-Seq_JURKAT_Human3.22446942
17SMAD_19615063_ChIP-ChIP_OVARY_Human3.10889587
18EZH2_22144423_ChIP-Seq_EOC_Human3.03003032
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.78516954
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.74399642
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.72802100
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.61019363
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.58335359
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52932977
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.43353539
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32771225
27XRN2_22483619_ChIP-Seq_HELA_Human2.27464772
28STAT4_19710469_ChIP-ChIP_TH1__Mouse2.20896319
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19465477
30CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.16707549
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.12035087
32VDR_23849224_ChIP-Seq_CD4+_Human2.11137809
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.09690873
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99943147
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99912333
36MYC_18940864_ChIP-ChIP_HL60_Human1.98820539
37TTF2_22483619_ChIP-Seq_HELA_Human1.98227273
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97091218
39FOXP3_21729870_ChIP-Seq_TREG_Human1.96424518
40GABP_19822575_ChIP-Seq_HepG2_Human1.92737301
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91778276
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.91070959
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89878391
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87463676
45ELK1_19687146_ChIP-ChIP_HELA_Human1.86276848
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85253922
47VDR_24787735_ChIP-Seq_THP-1_Human1.83273085
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.81556969
49ZNF274_21170338_ChIP-Seq_K562_Hela1.78446451
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77766283
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.75846726
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70773280
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.68575473
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.59680911
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55939288
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.54431788
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51713172
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51597931
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50593333
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.49930115
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48251579
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46138854
63DCP1A_22483619_ChIP-Seq_HELA_Human1.43954068
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36619183
65ZNF263_19887448_ChIP-Seq_K562_Human1.36479018
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32189420
67KDM5A_27292631_Chip-Seq_BREAST_Human1.31990517
68TP53_18474530_ChIP-ChIP_U2OS_Human1.31848174
69* FOXP1_21924763_ChIP-Seq_HESCs_Human1.31648729
70BCL6_27268052_Chip-Seq_Bcells_Human1.31499335
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30547105
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29909260
73TP53_22573176_ChIP-Seq_HFKS_Human1.29902868
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29413981
75GATA1_22025678_ChIP-Seq_K562_Human1.29143080
76SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28418869
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27112894
78MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26919424
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24944508
80NANOG_20526341_ChIP-Seq_ESCs_Human1.24322392
81ERA_21632823_ChIP-Seq_H3396_Human1.23999385
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23348185
83SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20531180
84CIITA_25753668_ChIP-Seq_RAJI_Human1.19973406
85CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19007246
86SMRT_27268052_Chip-Seq_Bcells_Human1.15905397
87* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15467669
88IGF1R_20145208_ChIP-Seq_DFB_Human1.15045410
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.14564395
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13871322
91SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13871322
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13616524
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13198646
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12711909
95TAF2_19829295_ChIP-Seq_ESCs_Human1.11556261
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10793925
97EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10276595
98P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10045864
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09966484
100* GATA3_26560356_Chip-Seq_TH2_Human1.09925070
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08967957
102BP1_19119308_ChIP-ChIP_Hs578T_Human1.08208184
103P68_20966046_ChIP-Seq_HELA_Human1.08088737
104EWS_26573619_Chip-Seq_HEK293_Human1.06063855
105TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05101301
106P53_21459846_ChIP-Seq_SAOS-2_Human1.05035852
107* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04980925
108SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04949589
109ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03055871
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03031982
111POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02217337
112GATA3_21878914_ChIP-Seq_MCF-7_Human1.01235269
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01226967
114E2F1_20622854_ChIP-Seq_HELA_Human1.00684038
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00394846
116SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99224469
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99118607
118SOX2_20726797_ChIP-Seq_SW620_Human0.99042345
119PHF8_20622854_ChIP-Seq_HELA_Human0.98232375
120* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98148117
121SOX2_16153702_ChIP-ChIP_HESCs_Human0.98038214
122MYC_19829295_ChIP-Seq_ESCs_Human0.97597394
123PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97591638
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96491474
125CBX2_27304074_Chip-Seq_ESCs_Mouse0.96472323
126ELK1_22589737_ChIP-Seq_MCF10A_Human0.96181317
127STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95940008
128IRF1_19129219_ChIP-ChIP_H3396_Human0.95905495
129NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94900550
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94900550
131KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94221240
132CTCF_20526341_ChIP-Seq_ESCs_Human0.94067734
133E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94020518
134MAF_26560356_Chip-Seq_TH1_Human0.93948047
135TP63_23658742_ChIP-Seq_EP156T_Human0.93185966
136SMAD3_21741376_ChIP-Seq_HESCs_Human0.92500599
137NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92063878
138MYB_26560356_Chip-Seq_TH2_Human0.91962066
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.91557807
140TET1_21451524_ChIP-Seq_MESCs_Mouse0.90875972
141* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90591616
142P300_19829295_ChIP-Seq_ESCs_Human0.90574198
143CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89903277
144HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89799837
145YY1_22570637_ChIP-Seq_MALME-3M_Human0.89108194
146KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89078799
147BCOR_27268052_Chip-Seq_Bcells_Human0.88476450
148GATA3_21867929_ChIP-Seq_TH1_Mouse0.87141621
149FLI1_27457419_Chip-Seq_LIVER_Mouse0.85927591
150PU1_27457419_Chip-Seq_LIVER_Mouse0.85676939
151EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85529021
152PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85296447
153LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84859376
154NCOR_22424771_ChIP-Seq_293T_Human0.84505323
155* CTCF_26484167_Chip-Seq_Bcells_Mouse0.84425462
156CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84126763
157EGR1_19032775_ChIP-ChIP_M12_Human0.83270130
158SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.82369034
159CMYC_18555785_Chip-Seq_ESCs_Mouse0.82273770
160FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82064858
161NANOG_18555785_Chip-Seq_ESCs_Mouse0.81481854
162FOXO3_23340844_ChIP-Seq_DLD1_Human0.81471797
163CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80376900
164RUNX_20019798_ChIP-Seq_JUKART_Human0.80348781
165NMYC_18555785_Chip-Seq_ESCs_Mouse0.80280154
166SOX2_18555785_Chip-Seq_ESCs_Mouse0.78861667
167PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78604653
168GATA3_27048872_Chip-Seq_THYMUS_Human0.76887642
169FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.75214381
170JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74654400
171CDX2_22108803_ChIP-Seq_LS180_Human0.73784297
172SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.73362742
173NR3C1_23031785_ChIP-Seq_PC12_Mouse0.73192069
174MYB_26560356_Chip-Seq_TH1_Human0.71838151
175* SPI1_23547873_ChIP-Seq_NB4_Human0.71757737
176PU_27001747_Chip-Seq_BMDM_Mouse0.71707667
177STAT3_18555785_Chip-Seq_ESCs_Mouse0.71400855
178* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71380960
179JARID2_20064375_ChIP-Seq_MESCs_Mouse0.70952447
180TCF4_22108803_ChIP-Seq_LS180_Human0.70631214
181EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.69863891
182AR_25329375_ChIP-Seq_VCAP_Human0.69554710
183EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.68315235
184PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.68199831
185IKZF1_21737484_ChIP-ChIP_HCT116_Human0.67756041
186BMI1_23680149_ChIP-Seq_NPCS_Mouse0.67351417
187CJUN_26792858_Chip-Seq_BT549_Human0.67344984
188VDR_22108803_ChIP-Seq_LS180_Human0.66871704
189* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.66572034
190ER_23166858_ChIP-Seq_MCF-7_Human0.65673220
191TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.64944854
192RXR_22108803_ChIP-Seq_LS180_Human0.64766311
193SUZ12_18555785_Chip-Seq_ESCs_Mouse0.64116384
194JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63741376
195EZH2_27294783_Chip-Seq_NPCs_Mouse0.63237018
196* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62849653
197P53_22387025_ChIP-Seq_ESCs_Mouse0.62562231
198CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62200450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology5.88931803
2MP0001348_abnormal_lacrimal_gland5.25607575
3MP0006292_abnormal_olfactory_placode4.91380884
4MP0001346_abnormal_lacrimal_gland4.67357983
5MP0002254_reproductive_system_inflammat4.51951691
6MP0002138_abnormal_hepatobiliary_system4.40300171
7MP0000685_abnormal_immune_system4.34075586
8MP0009379_abnormal_foot_pigmentation4.33311512
9MP0001835_abnormal_antigen_presentation4.32062766
10MP0002009_preneoplasia3.66727999
11MP0002148_abnormal_hypersensitivity_rea3.47735473
12MP0004510_myositis3.35097739
13MP0005379_endocrine/exocrine_gland_phen3.24417505
14MP0002166_altered_tumor_susceptibility3.13369308
15MP0001790_abnormal_immune_system2.91308505
16MP0005387_immune_system_phenotype2.91308505
17MP0002006_tumorigenesis2.77633858
18MP0005310_abnormal_salivary_gland2.72621455
19MP0001986_abnormal_taste_sensitivity2.49918956
20MP0009785_altered_susceptibility_to2.41592011
21MP0002653_abnormal_ependyma_morphology2.39388748
22MP0001905_abnormal_dopamine_level2.37362339
23MP0002736_abnormal_nociception_after2.32083178
24MP0002796_impaired_skin_barrier2.31045866
25MP0003436_decreased_susceptibility_to2.30390293
26MP0008789_abnormal_olfactory_epithelium2.25504228
27MP0004147_increased_porphyrin_level2.24767867
28MP0002638_abnormal_pupillary_reflex2.23954024
29MP0010234_abnormal_vibrissa_follicle2.20930277
30MP0002277_abnormal_respiratory_mucosa2.16897491
31MP0005000_abnormal_immune_tolerance2.13093614
32MP0005671_abnormal_response_to2.12906575
33MP0003941_abnormal_skin_development2.09729457
34MP0003136_yellow_coat_color2.09354655
35MP0002876_abnormal_thyroid_physiology2.06415370
36MP0008877_abnormal_DNA_methylation1.97546165
37MP0002837_dystrophic_cardiac_calcinosis1.97084419
38MP0004133_heterotaxia1.95042044
39MP0006072_abnormal_retinal_apoptosis1.90136947
40MP0008875_abnormal_xenobiotic_pharmacok1.89429273
41MP0003011_delayed_dark_adaptation1.88237388
42MP0001188_hyperpigmentation1.84874682
43MP0001800_abnormal_humoral_immune1.84136709
44MP0006036_abnormal_mitochondrial_physio1.76451581
45MP0000631_abnormal_neuroendocrine_gland1.74546565
46MP0005423_abnormal_somatic_nervous1.73504112
47MP0002095_abnormal_skin_pigmentation1.73262179
48MP0002723_abnormal_immune_serum1.72869549
49MP0002452_abnormal_antigen_presenting1.71716731
50MP0003806_abnormal_nucleotide_metabolis1.68467254
51MP0005025_abnormal_response_to1.67377457
52MP0001853_heart_inflammation1.64810815
53MP0004142_abnormal_muscle_tone1.63046740
54MP0004947_skin_inflammation1.62364498
55MP0001819_abnormal_immune_cell1.56253809
56MP0010386_abnormal_urinary_bladder1.55374177
57MP0003186_abnormal_redox_activity1.55218461
58MP0003693_abnormal_embryo_hatching1.55001378
59MP0005394_taste/olfaction_phenotype1.53377258
60MP0005499_abnormal_olfactory_system1.53377258
61MP0003718_maternal_effect1.52998018
62MP0005646_abnormal_pituitary_gland1.52850145
63MP0002877_abnormal_melanocyte_morpholog1.52153523
64MP0002160_abnormal_reproductive_system1.51062468
65MP0002420_abnormal_adaptive_immunity1.48668799
66MP0005551_abnormal_eye_electrophysiolog1.47933589
67MP0001293_anophthalmia1.46536149
68MP0002419_abnormal_innate_immunity1.40663158
69MP0003880_abnormal_central_pattern1.39057270
70MP0002938_white_spotting1.38316087
71MP0003453_abnormal_keratinocyte_physiol1.34759924
72MP0005645_abnormal_hypothalamus_physiol1.34399495
73MP0004885_abnormal_endolymph1.32217674
74MP0002132_abnormal_respiratory_system1.31710000
75MP0009278_abnormal_bone_marrow1.30002108
76MP0005253_abnormal_eye_physiology1.25754417
77MP0003121_genomic_imprinting1.24471949
78MP0010030_abnormal_orbit_morphology1.20522887
79MP0005501_abnormal_skin_physiology1.20258246
80MP0001764_abnormal_homeostasis1.19643747
81MP0003123_paternal_imprinting1.17179617
82MP0002735_abnormal_chemical_nociception1.16553142
83MP0006082_CNS_inflammation1.16099226
84MP0008058_abnormal_DNA_repair1.13237230
85MP0002210_abnormal_sex_determination1.13083890
86MP0000716_abnormal_immune_system1.13005287
87MP0005389_reproductive_system_phenotype1.09975241
88MP0000372_irregular_coat_pigmentation1.09917022
89MP0005623_abnormal_meninges_morphology1.09470303
90MP0006276_abnormal_autonomic_nervous1.07972504
91MP0003122_maternal_imprinting1.06674245
92MP0001216_abnormal_epidermal_layer1.06516970
93MP0001502_abnormal_circadian_rhythm1.05520402
94MP0005377_hearing/vestibular/ear_phenot1.04681857
95MP0003878_abnormal_ear_physiology1.04681857
96MP0001529_abnormal_vocalization1.02883529
97MP0000015_abnormal_ear_pigmentation1.02155319
98MP0010094_abnormal_chromosome_stability1.01608252
99MP0002272_abnormal_nervous_system1.01575603
100MP0005195_abnormal_posterior_eye1.00144402
101MP0000049_abnormal_middle_ear1.00065192
102MP0006035_abnormal_mitochondrial_morpho0.98276008
103MP0002398_abnormal_bone_marrow0.98224843
104MP0000569_abnormal_digit_pigmentation0.98155086
105MP0003091_abnormal_cell_migration0.97158177
106MP0005171_absent_coat_pigmentation0.96747075
107MP0003763_abnormal_thymus_physiology0.96618826
108MP0001929_abnormal_gametogenesis0.94188920
109MP0000026_abnormal_inner_ear0.93277767
110MP0002557_abnormal_social/conspecific_i0.92851882
111MP0002405_respiratory_system_inflammati0.92761753
112MP0005076_abnormal_cell_differentiation0.92544440
113MP0003938_abnormal_ear_development0.91610479
114MP0002234_abnormal_pharynx_morphology0.91256654
115MP0001145_abnormal_male_reproductive0.90263319
116MP0009764_decreased_sensitivity_to0.89784966
117MP0003724_increased_susceptibility_to0.89576963
118MP0001970_abnormal_pain_threshold0.89320110
119MP0000653_abnormal_sex_gland0.87893415
120MP0002572_abnormal_emotion/affect_behav0.87870988
121MP0000627_abnormal_mammary_gland0.86623887
122MP0005391_vision/eye_phenotype0.86096509
123MP0002822_catalepsy0.85991660
124MP0008872_abnormal_physiological_respon0.85747500
125MP0001286_abnormal_eye_development0.83434795
126MP0003698_abnormal_male_reproductive0.83132122
127MP0005332_abnormal_amino_acid0.82009079
128MP0001845_abnormal_inflammatory_respons0.81437030
129MP0003191_abnormal_cellular_cholesterol0.81187727
130MP0000538_abnormal_urinary_bladder0.81012581
131MP0005410_abnormal_fertilization0.80655577
132MP0004782_abnormal_surfactant_physiolog0.80435347
133MP0003315_abnormal_perineum_morphology0.80333156
134MP0001984_abnormal_olfaction0.80200824
135MP0002067_abnormal_sensory_capabilities0.79648371
136MP0004019_abnormal_vitamin_homeostasis0.79047802
137MP0001485_abnormal_pinna_reflex0.78787593
138MP0004381_abnormal_hair_follicle0.78045855
139MP0001881_abnormal_mammary_gland0.76497844
140MP0001873_stomach_inflammation0.76120485
141MP0004145_abnormal_muscle_electrophysio0.76114462
142MP0004742_abnormal_vestibular_system0.75983461
143MP0002429_abnormal_blood_cell0.74980138
144MP0000778_abnormal_nervous_system0.74931887
145MP0002752_abnormal_somatic_nervous0.74911838
146MP0001944_abnormal_pancreas_morphology0.74848975
147MP0003786_premature_aging0.74200476
148MP0010771_integument_phenotype0.71897271
149MP0005275_abnormal_skin_tensile0.69875664
150MP0009046_muscle_twitch0.68072881
151MP0001533_abnormal_skeleton_physiology0.68042170
152MP0003448_altered_tumor_morphology0.66814509
153MP0008469_abnormal_protein_level0.66809759
154MP0010678_abnormal_skin_adnexa0.65866553
155MP0001191_abnormal_skin_condition0.63819106
156MP0004185_abnormal_adipocyte_glucose0.63083405
157MP0000383_abnormal_hair_follicle0.60820192
158MP0002722_abnormal_immune_system0.60099340
159MP0002102_abnormal_ear_morphology0.59351341
160MP0003183_abnormal_peptide_metabolism0.58801906
161MP0004858_abnormal_nervous_system0.58214933
162MP0000613_abnormal_salivary_gland0.58107027
163MP0010155_abnormal_intestine_physiology0.57472238
164MP0003566_abnormal_cell_adhesion0.57102424
165MP0000858_altered_metastatic_potential0.52411013
166MP0003787_abnormal_imprinting0.52069110
167MP0001243_abnormal_dermal_layer0.50309260
168MP0000689_abnormal_spleen_morphology0.49414688
169MP0000367_abnormal_coat/_hair0.48657817
170MP0009745_abnormal_behavioral_response0.48546934
171MP0001968_abnormal_touch/_nociception0.47978058
172MP0004859_abnormal_synaptic_plasticity0.45904242
173MP0002295_abnormal_pulmonary_circulatio0.43908249
174MP0005174_abnormal_tail_pigmentation0.42853161
175MP0000681_abnormal_thyroid_gland0.42799901
176MP0000703_abnormal_thymus_morphology0.42331345
177MP0001765_abnormal_ion_homeostasis0.40177524
178MP0002060_abnormal_skin_morphology0.39466595
179MP0005367_renal/urinary_system_phenotyp0.38832010
180MP0000516_abnormal_urinary_system0.38832010
181MP0002098_abnormal_vibrissa_morphology0.37472967
182MP0009931_abnormal_skin_appearance0.37420390
183MP0000604_amyloidosis0.37304903
184MP0002998_abnormal_bone_remodeling0.34600413
185MP0001879_abnormal_lymphatic_vessel0.33905027
186MP0005084_abnormal_gallbladder_morpholo0.33731031

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)9.01157191
2Autoimmune thrombocytopenia (HP:0001973)7.03420588
3Optic neuritis (HP:0100653)5.00962756
4Retrobulbar optic neuritis (HP:0100654)5.00962756
5Hypergammaglobulinemia (HP:0010702)4.97123910
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.70555551
7Abnormal delayed hypersensitivity skin test (HP:0002963)4.64162469
8Autoimmune hemolytic anemia (HP:0001890)4.60369405
9Orchitis (HP:0100796)4.38171647
10Abnormality of cells of the erythroid lineage (HP:0012130)4.27808101
11Parakeratosis (HP:0001036)4.20393034
12Mitochondrial inheritance (HP:0001427)4.14674343
13Abnormal number of erythroid precursors (HP:0012131)4.14058022
14Hypochromic anemia (HP:0001931)4.11575938
15Eosinophilia (HP:0001880)4.07352857
16Reticulocytopenia (HP:0001896)3.96286566
17Recurrent bacterial skin infections (HP:0005406)3.95056158
18Acute necrotizing encephalopathy (HP:0006965)3.91559169
19Vasculitis (HP:0002633)3.88704461
20Increased IgE level (HP:0003212)3.83176323
21Congenital ichthyosiform erythroderma (HP:0007431)3.83097591
22Myositis (HP:0100614)3.77473116
23Renal Fanconi syndrome (HP:0001994)3.77276719
24Molar tooth sign on MRI (HP:0002419)3.76841514
25Abnormality of midbrain morphology (HP:0002418)3.76841514
26Abnormal mitochondria in muscle tissue (HP:0008316)3.74225091
27Hepatocellular necrosis (HP:0001404)3.73319489
28Increased hepatocellular lipid droplets (HP:0006565)3.72975529
29Recurrent fungal infections (HP:0002841)3.72030264
30Recurrent abscess formation (HP:0002722)3.64612494
31Eczematoid dermatitis (HP:0000976)3.63428425
32Anhidrosis (HP:0000970)3.61079608
33Elevated erythrocyte sedimentation rate (HP:0003565)3.59921958
34Mediastinal lymphadenopathy (HP:0100721)3.58418018
35Increased CSF lactate (HP:0002490)3.58124507
36Lipid accumulation in hepatocytes (HP:0006561)3.49596915
37Gastrointestinal infarctions (HP:0005244)3.48675360
38Lip pit (HP:0100267)3.46112488
39Acute encephalopathy (HP:0006846)3.41095529
40Tetraparesis (HP:0002273)3.39936263
41Granulocytopenia (HP:0001913)3.39079162
42Hepatic necrosis (HP:0002605)3.34153799
43Recurrent viral infections (HP:0004429)3.29327568
44Abnormality of T cell number (HP:0011839)3.27372414
45Chronic otitis media (HP:0000389)3.19298036
46Pancreatic cysts (HP:0001737)3.16363676
47Progressive macrocephaly (HP:0004481)3.13154297
48Congenital stationary night blindness (HP:0007642)3.12490748
49Porencephaly (HP:0002132)3.11802756
50Increased intramyocellular lipid droplets (HP:0012240)3.11710508
51Pancreatic fibrosis (HP:0100732)3.10668894
52Decreased activity of mitochondrial respiratory chain (HP:0008972)3.06389895
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.06389895
54Macrocytic anemia (HP:0001972)3.06161447
55Abnormality of eosinophils (HP:0001879)3.06068161
56Gangrene (HP:0100758)3.04054142
57Medial flaring of the eyebrow (HP:0010747)3.03797418
58Hypothermia (HP:0002045)3.03596380
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.98366611
60Pulmonary infiltrates (HP:0002113)2.93605391
61Abnormality of macrophages (HP:0004311)2.90582693
62Nephronophthisis (HP:0000090)2.86216741
63Pallor (HP:0000980)2.85169105
64Arterial thrombosis (HP:0004420)2.84007810
65Leukocytosis (HP:0001974)2.83941900
66Basal ganglia calcification (HP:0002135)2.79944751
67Exertional dyspnea (HP:0002875)2.76702672
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.74611546
69Joint swelling (HP:0001386)2.74197529
70Chronic hepatic failure (HP:0100626)2.73801557
71Increased muscle lipid content (HP:0009058)2.72628010
72Septo-optic dysplasia (HP:0100842)2.72368072
73Agammaglobulinemia (HP:0004432)2.71765301
74Urticaria (HP:0001025)2.66300798
75Keratoconjunctivitis sicca (HP:0001097)2.64889424
76Keratoconjunctivitis (HP:0001096)2.62718401
77Absent thumb (HP:0009777)2.59777589
783-Methylglutaconic aciduria (HP:0003535)2.59178683
79Erythema (HP:0010783)2.55106356
80Fatigue (HP:0012378)2.54883684
81Increased serum lactate (HP:0002151)2.51047222
82Periodontitis (HP:0000704)2.50756547
83Premature loss of primary teeth (HP:0006323)2.49144367
84True hermaphroditism (HP:0010459)2.47607302
85Cortical dysplasia (HP:0002539)2.47458635
86Recurrent skin infections (HP:0001581)2.47433317
87Vertebral compression fractures (HP:0002953)2.46519738
88Nasal polyposis (HP:0100582)2.45228737
89Panhypogammaglobulinemia (HP:0003139)2.44855285
90Methylmalonic acidemia (HP:0002912)2.43913758
91Abnormal drinking behavior (HP:0030082)2.42957461
92Polydipsia (HP:0001959)2.42957461
93Pendular nystagmus (HP:0012043)2.42664889
94Abnormality of renal resorption (HP:0011038)2.42458798
95Adrenal hypoplasia (HP:0000835)2.42033563
96Chronic sinusitis (HP:0011109)2.41973303
97Gait imbalance (HP:0002141)2.39173695
98Lactic acidosis (HP:0003128)2.38116121
99Rib fusion (HP:0000902)2.36622768
100Abnormality of the renal medulla (HP:0100957)2.36601374
101Prostate neoplasm (HP:0100787)2.36536960
102Congenital primary aphakia (HP:0007707)2.36028637
103Chronic mucocutaneous candidiasis (HP:0002728)2.34788883
104Recurrent cutaneous fungal infections (HP:0011370)2.34788883
105Type I transferrin isoform profile (HP:0003642)2.34037336
106Hypohidrosis (HP:0000966)2.32887002
107Optic disc pallor (HP:0000543)2.32355824
108Methylmalonic aciduria (HP:0012120)2.31046058
109Exercise intolerance (HP:0003546)2.29914256
110Peritonitis (HP:0002586)2.29794669
111Hyperglycinemia (HP:0002154)2.26605537
112Asplenia (HP:0001746)2.26259735
113Nephrogenic diabetes insipidus (HP:0009806)2.25442364
114Sclerocornea (HP:0000647)2.22175364
115Myokymia (HP:0002411)2.21456428
116Congenital hepatic fibrosis (HP:0002612)2.21171797
117Respiratory difficulties (HP:0002880)2.20949701
118Thrombocytosis (HP:0001894)2.19103089
119Cerebral edema (HP:0002181)2.18811840
120Cleft eyelid (HP:0000625)2.18743676
121Aplasia/Hypoplasia of the spleen (HP:0010451)2.18563363
122Recurrent gram-negative bacterial infections (HP:0005420)2.18065216
123Hydroxyprolinuria (HP:0003080)2.15859330
124Abnormality of proline metabolism (HP:0010907)2.15859330
125Hypoplasia of the pons (HP:0012110)2.14870325
126Erythroderma (HP:0001019)2.11448918
127Conical tooth (HP:0000698)2.10218655
128Hyperthyroidism (HP:0000836)2.08773581
129Neutropenia (HP:0001875)2.08723498
130Encephalitis (HP:0002383)2.06488288
131Respiratory failure (HP:0002878)2.06305219
132Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03706782
133Abnormal protein N-linked glycosylation (HP:0012347)2.03706782
134Abnormal protein glycosylation (HP:0012346)2.03706782
135Abnormal glycosylation (HP:0012345)2.03706782
136Cerebral hemorrhage (HP:0001342)2.03021982
137B lymphocytopenia (HP:0010976)2.02086809
138Median cleft lip (HP:0000161)2.01261493
139Abnormality of the pons (HP:0007361)2.00355733
140Retinal dysplasia (HP:0007973)1.99574430
141Hemoptysis (HP:0002105)1.98896504
142Abnormality of B cell number (HP:0010975)1.98602688
143Hypertensive crisis (HP:0100735)1.97490270
144Colon cancer (HP:0003003)1.95489434
145Type 2 muscle fiber atrophy (HP:0003554)1.95412338
146Abnormality of T cell physiology (HP:0011840)1.95108230
147IgG deficiency (HP:0004315)1.94342150
148Meningitis (HP:0001287)1.92908765
149Obstructive lung disease (HP:0006536)1.92846403
150Chronic obstructive pulmonary disease (HP:0006510)1.92846403
151Vertigo (HP:0002321)1.91528285
152Bile duct proliferation (HP:0001408)1.91211286
153Abnormal biliary tract physiology (HP:0012439)1.91211286
154Ectropion (HP:0000656)1.90294014
155Muscle fiber atrophy (HP:0100295)1.89921986
156Limb dystonia (HP:0002451)1.88925643
157Lethargy (HP:0001254)1.88231915
158Polyuria (HP:0000103)1.87474714
159Testicular atrophy (HP:0000029)1.87055358
160Abnormality of DNA repair (HP:0003254)1.86981426
161Osteolytic defects of the phalanges of the hand (HP:0009771)1.85410654
162Osteolytic defects of the hand bones (HP:0009699)1.85410654
163Enlarged kidneys (HP:0000105)1.85088076
164Abnormality of cells of the lymphoid lineage (HP:0012140)1.85000845
165Anophthalmia (HP:0000528)1.84787910
166Abnormality of urine glucose concentration (HP:0011016)1.84450701
167Glycosuria (HP:0003076)1.84450701
168Cystic liver disease (HP:0006706)1.83910083
169Abnormality of the pericardium (HP:0001697)1.83723352
170IgA deficiency (HP:0002720)1.81047622
171Gingivitis (HP:0000230)1.80494406
172Abnormal hair whorl (HP:0010721)1.79804753
173Palpebral edema (HP:0100540)1.79269791
174Pruritus (HP:0000989)1.78645053
175Facial hemangioma (HP:0000329)1.77646881
176Hypercortisolism (HP:0001578)1.76532793
177Abnormality of the renal cortex (HP:0011035)1.76395723
178Abnormality of the nasal mucosa (HP:0000433)1.76091373
179Abnormal rod and cone electroretinograms (HP:0008323)1.75463895
180Abnormality of the gastric mucosa (HP:0004295)1.74990833
181Optic nerve hypoplasia (HP:0000609)1.74634045
182Alveolar cell carcinoma (HP:0006519)1.74384625
183Aplasia/Hypoplasia of the tongue (HP:0010295)1.74209427
184Colitis (HP:0002583)1.74098678
185Abnormality of the periventricular white matter (HP:0002518)1.74078201
186Sepsis (HP:0100806)1.72848868
187Male pseudohermaphroditism (HP:0000037)1.72817710
188Portal hypertension (HP:0001409)1.72796724
189CNS demyelination (HP:0007305)1.72465441
190Attenuation of retinal blood vessels (HP:0007843)1.72352686
191Aganglionic megacolon (HP:0002251)1.72243839
192Febrile seizures (HP:0002373)1.70968683
193Cerebral ischemia (HP:0002637)1.70830987
194Vaginal atresia (HP:0000148)1.70669003
195Amaurosis fugax (HP:0100576)1.70617986
196Facial diplegia (HP:0001349)1.69954082
197Abnormality of the hepatic vasculature (HP:0006707)1.69929300
198Microretrognathia (HP:0000308)1.69113443
199Genital tract atresia (HP:0001827)1.68862746

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K147.20194587
2MAP3K135.19501067
3BCR4.63412465
4IKBKB3.62834688
5TLK13.57705467
6ARAF3.35036136
7TYK23.22488400
8PIM23.13076557
9BCKDK3.11565599
10STK162.98893696
11TBK12.92096774
12TAOK32.87172050
13CHUK2.73929274
14JAK32.69398544
15VRK22.53341500
16TESK22.48907970
17IKBKE2.20352102
18WNK42.15236511
19BMPR22.14104418
20NUAK12.11902898
21GRK12.09669044
22CDC72.02638476
23MUSK2.00069411
24MAPK151.98508506
25RIPK41.91261709
26JAK11.81571975
27BUB11.76431380
28TESK11.69506627
29DYRK21.69263649
30PKN11.66061214
31MAP3K91.63805421
32IRAK41.60734264
33MAP4K21.53565673
34VRK11.50475732
35MST41.42898456
36PINK11.41807594
37CASK1.40504544
38SYK1.39169438
39PDK21.37195696
40PHKG11.35188381
41PHKG21.35188381
42BMPR1B1.33275653
43BRAF1.28679763
44NME21.27735634
45GRK71.20939306
46WNK31.18402311
47BRSK11.15698368
48DYRK31.14411914
49EIF2AK21.13921661
50MAPKAPK31.13589507
51CHEK21.10510400
52NME11.08111434
53CSNK1G31.07733628
54MAP3K111.06082677
55MOS1.05165943
56CSNK1G21.03368653
57CSNK1G11.00639139
58MAP3K120.99121915
59NTRK30.98592922
60MAPK130.98423088
61MAPKAPK20.98161536
62CDK190.97640227
63EPHB10.97600421
64ACVR1B0.96947866
65ATR0.91596983
66FLT30.90446067
67RAF10.89250398
68STK240.88790569
69PLK10.88718113
70PRKCG0.85887994
71PRKCE0.83453428
72MKNK20.82620279
73CCNB10.82241288
74PIM10.81479050
75SIK30.80892649
76EIF2AK30.80491921
77FGFR40.80242095
78LIMK10.79205007
79AURKB0.75278741
80GRK50.74869297
81TRPM70.74866307
82PRKCQ0.74851926
83MAPKAPK50.73880928
84MARK30.73758854
85PRKCI0.73729449
86PNCK0.72316210
87PTK60.72093225
88ADRBK20.70512423
89PRKAA20.69807312
90NEK90.68848360
91AURKA0.68436614
92NEK20.68302230
93PTK2B0.66611077
94MAP3K40.66025125
95KIT0.65555670
96INSRR0.64540085
97TNK20.63930951
98FGFR30.62950330
99JAK20.62600900
100ADRBK10.62254530
101KSR20.61736791
102BMX0.61564058
103PLK30.61490159
104WEE10.61348519
105PRKCD0.60911909
106RPS6KA10.57681275
107MAP3K10.57128631
108PLK40.56533563
109RPS6KA50.56031661
110PBK0.55737387
111BLK0.54549007
112BRSK20.54037878
113TTK0.53612203
114MAP2K70.53438894
115SRPK10.52693886
116FRK0.52559545
117CSNK2A10.52156758
118PAK30.51680762
119CSNK2A20.49793538
120STK390.49404927
121ERBB30.48451219
122NTRK10.47250852
123IRAK30.46468810
124PRKACA0.46132957
125YES10.44684094
126MAP2K60.44629426
127TAF10.44305126
128PRKCZ0.43959995
129EPHA40.43191392
130CDK11A0.42703665
131SIK20.42662566
132PASK0.42057040
133MAP4K10.41915156
134ZAK0.40988882
135SGK10.40878622
136PIK3CA0.40246964
137STK110.39927019
138MST1R0.39246371
139MAP2K20.39219585
140LCK0.39182715
141ATM0.37158681
142CSF1R0.36699508
143MKNK10.36517339
144RPS6KB20.35984804
145PRKACB0.35697532
146TIE10.35620498
147EPHA30.35093444
148AKT10.33756998
149ABL20.33331748
150FER0.31752322
151DAPK30.31714905
152LRRK20.30377881
153BTK0.28895772
154TNIK0.28850239
155NTRK20.27200370
156HCK0.27134056
157MAP3K30.26535423
158MAP2K10.26490706
159MAP3K20.23746514
160EPHB20.23578325
161PAK10.23460193
162WNK10.22803203
163FGR0.22748791
164ABL10.22616841
165STK40.22276788
166DYRK1B0.21490229
167EGFR0.21398938
168GRK60.21114858
169PLK20.20925583
170PRKCB0.20054421
171MATK0.18932833
172IRAK10.17899040

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053305.35590876
2Graft-versus-host disease_Homo sapiens_hsa053324.41398421
3Autoimmune thyroid disease_Homo sapiens_hsa053203.81455214
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.50693034
5Type I diabetes mellitus_Homo sapiens_hsa049403.23768087
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.11731154
7RNA polymerase_Homo sapiens_hsa030202.91376769
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.54832533
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.46248115
10Homologous recombination_Homo sapiens_hsa034402.45044235
11Huntingtons disease_Homo sapiens_hsa050162.44407353
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.41754742
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.37522685
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25959889
15Sulfur relay system_Homo sapiens_hsa041222.22091354
16Toll-like receptor signaling pathway_Homo sapiens_hsa046202.02586461
17Base excision repair_Homo sapiens_hsa034102.02164463
18Fanconi anemia pathway_Homo sapiens_hsa034601.97720750
19TNF signaling pathway_Homo sapiens_hsa046681.95723840
20Protein export_Homo sapiens_hsa030601.89052343
21Fatty acid elongation_Homo sapiens_hsa000621.89051815
22Measles_Homo sapiens_hsa051621.84565414
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.83023209
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82016124
25Rheumatoid arthritis_Homo sapiens_hsa053231.79503751
26Proteasome_Homo sapiens_hsa030501.79238515
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76442905
28Leishmaniasis_Homo sapiens_hsa051401.76298544
29DNA replication_Homo sapiens_hsa030301.71265436
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.68117387
31Toxoplasmosis_Homo sapiens_hsa051451.59826756
32Pyrimidine metabolism_Homo sapiens_hsa002401.56863210
33Mismatch repair_Homo sapiens_hsa034301.55688143
34African trypanosomiasis_Homo sapiens_hsa051431.54402680
35Apoptosis_Homo sapiens_hsa042101.54018783
36Influenza A_Homo sapiens_hsa051641.49918713
37Viral myocarditis_Homo sapiens_hsa054161.49608613
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.47460096
39Basal transcription factors_Homo sapiens_hsa030221.44908036
40RNA degradation_Homo sapiens_hsa030181.44142344
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43567586
42Phenylalanine metabolism_Homo sapiens_hsa003601.42096806
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40992463
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40284456
45Chemokine signaling pathway_Homo sapiens_hsa040621.38124210
46Nucleotide excision repair_Homo sapiens_hsa034201.36683894
47Selenocompound metabolism_Homo sapiens_hsa004501.32708601
48One carbon pool by folate_Homo sapiens_hsa006701.31019383
49Osteoclast differentiation_Homo sapiens_hsa043801.28534070
50Herpes simplex infection_Homo sapiens_hsa051681.28299078
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.27312357
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26647474
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24255618
54Phototransduction_Homo sapiens_hsa047441.21311890
55Antigen processing and presentation_Homo sapiens_hsa046121.19348223
56Collecting duct acid secretion_Homo sapiens_hsa049661.18188618
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.11850253
58Pertussis_Homo sapiens_hsa051331.05231166
59Asthma_Homo sapiens_hsa053101.04043579
60Propanoate metabolism_Homo sapiens_hsa006401.02066498
61Shigellosis_Homo sapiens_hsa051311.01849324
62Spliceosome_Homo sapiens_hsa030401.01662824
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00818793
64Steroid biosynthesis_Homo sapiens_hsa001001.00415570
65Primary immunodeficiency_Homo sapiens_hsa053401.00277084
66p53 signaling pathway_Homo sapiens_hsa041150.99461502
67RNA transport_Homo sapiens_hsa030130.97773152
68Legionellosis_Homo sapiens_hsa051340.97358076
69Purine metabolism_Homo sapiens_hsa002300.97260644
70Pyruvate metabolism_Homo sapiens_hsa006200.96952598
71Tuberculosis_Homo sapiens_hsa051520.96005082
72Peroxisome_Homo sapiens_hsa041460.94598825
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93037933
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92322155
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90492533
76Epstein-Barr virus infection_Homo sapiens_hsa051690.89569444
77Metabolic pathways_Homo sapiens_hsa011000.89564847
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87340495
79Tryptophan metabolism_Homo sapiens_hsa003800.86626812
80Vitamin B6 metabolism_Homo sapiens_hsa007500.85525210
81Butanoate metabolism_Homo sapiens_hsa006500.81476242
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80936245
83Prolactin signaling pathway_Homo sapiens_hsa049170.78123483
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78037167
85Non-homologous end-joining_Homo sapiens_hsa034500.77812100
86Hepatitis C_Homo sapiens_hsa051600.77737044
87Glutathione metabolism_Homo sapiens_hsa004800.76401667
88T cell receptor signaling pathway_Homo sapiens_hsa046600.75979448
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75754113
90B cell receptor signaling pathway_Homo sapiens_hsa046620.73385650
91Nitrogen metabolism_Homo sapiens_hsa009100.71746673
92Chemical carcinogenesis_Homo sapiens_hsa052040.70125286
93Hepatitis B_Homo sapiens_hsa051610.70116326
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69392954
95Regulation of autophagy_Homo sapiens_hsa041400.69047530
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68623839
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67766427
98Serotonergic synapse_Homo sapiens_hsa047260.67490264
99Acute myeloid leukemia_Homo sapiens_hsa052210.66713096
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.65535337
101Small cell lung cancer_Homo sapiens_hsa052220.63252204
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63096191
103Salmonella infection_Homo sapiens_hsa051320.60684131
104Oxidative phosphorylation_Homo sapiens_hsa001900.60532319
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60512062
106Ether lipid metabolism_Homo sapiens_hsa005650.60415903
107Hedgehog signaling pathway_Homo sapiens_hsa043400.60292034
108Folate biosynthesis_Homo sapiens_hsa007900.60071851
109Cocaine addiction_Homo sapiens_hsa050300.58222990
110Basal cell carcinoma_Homo sapiens_hsa052170.56696626
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56530042
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55063889
113Synaptic vesicle cycle_Homo sapiens_hsa047210.54062858
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53241301
115ErbB signaling pathway_Homo sapiens_hsa040120.52938068
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.51573600
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50904435
118Vibrio cholerae infection_Homo sapiens_hsa051100.49942332
119Parkinsons disease_Homo sapiens_hsa050120.49873798
120Tyrosine metabolism_Homo sapiens_hsa003500.49582965
121Olfactory transduction_Homo sapiens_hsa047400.49273112
122Phagosome_Homo sapiens_hsa041450.47705802
123MAPK signaling pathway_Homo sapiens_hsa040100.46224999
124Malaria_Homo sapiens_hsa051440.46064849
125Glutamatergic synapse_Homo sapiens_hsa047240.45978175
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45555470
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.45390764
128Renin secretion_Homo sapiens_hsa049240.45123878
129Sphingolipid metabolism_Homo sapiens_hsa006000.44980839
130VEGF signaling pathway_Homo sapiens_hsa043700.44919483
131Ribosome_Homo sapiens_hsa030100.44777714
132Caffeine metabolism_Homo sapiens_hsa002320.44752726
133Fatty acid degradation_Homo sapiens_hsa000710.44371958
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.43516730
135Alzheimers disease_Homo sapiens_hsa050100.43367498
136Cholinergic synapse_Homo sapiens_hsa047250.43014756
137Dorso-ventral axis formation_Homo sapiens_hsa043200.41812417
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41454370
139Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40795435
140Taste transduction_Homo sapiens_hsa047420.40651118
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39553201
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39310395
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.39160045
144Viral carcinogenesis_Homo sapiens_hsa052030.38727533
145Nicotine addiction_Homo sapiens_hsa050330.38720038
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36824936
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.36683636
148Type II diabetes mellitus_Homo sapiens_hsa049300.36426098
149Morphine addiction_Homo sapiens_hsa050320.36320907
150Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36062756
151HTLV-I infection_Homo sapiens_hsa051660.33738075
152Arachidonic acid metabolism_Homo sapiens_hsa005900.32651870
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32439417
154Fatty acid metabolism_Homo sapiens_hsa012120.31225583
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30592978
156Vitamin digestion and absorption_Homo sapiens_hsa049770.30199584
157Ras signaling pathway_Homo sapiens_hsa040140.29251161
158Chronic myeloid leukemia_Homo sapiens_hsa052200.28969110
159Circadian entrainment_Homo sapiens_hsa047130.28220604
160beta-Alanine metabolism_Homo sapiens_hsa004100.27847376
161Retinol metabolism_Homo sapiens_hsa008300.27646136
162Oxytocin signaling pathway_Homo sapiens_hsa049210.26264248
163Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25621247
164Linoleic acid metabolism_Homo sapiens_hsa005910.25502199
165Fat digestion and absorption_Homo sapiens_hsa049750.25448941
166Cardiac muscle contraction_Homo sapiens_hsa042600.25325316
167Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24569539
168Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24424054
169Amoebiasis_Homo sapiens_hsa051460.24359797
170Sphingolipid signaling pathway_Homo sapiens_hsa040710.23118162
171Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22652815
172Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22300138
173GABAergic synapse_Homo sapiens_hsa047270.22143246
174HIF-1 signaling pathway_Homo sapiens_hsa040660.21903149
175Glycerolipid metabolism_Homo sapiens_hsa005610.20306371
176Arginine and proline metabolism_Homo sapiens_hsa003300.20017024
177Ovarian steroidogenesis_Homo sapiens_hsa049130.18362718
178Glycosaminoglycan degradation_Homo sapiens_hsa005310.17754091

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