NUDT18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)6.53299942
2acrosome reaction (GO:0007340)5.73354298
3sperm motility (GO:0030317)5.37161329
4cilium or flagellum-dependent cell motility (GO:0001539)5.30205348
5plasma membrane fusion (GO:0045026)5.25957741
6cell wall macromolecule metabolic process (GO:0044036)4.49368895
7cell wall macromolecule catabolic process (GO:0016998)4.49368895
8axonemal dynein complex assembly (GO:0070286)4.48314390
9epithelial cilium movement (GO:0003351)4.42044382
10multicellular organism reproduction (GO:0032504)4.40939583
11calcium ion-dependent exocytosis (GO:0017156)4.30885287
12motile cilium assembly (GO:0044458)4.19390965
13response to peptidoglycan (GO:0032494)4.17633348
14positive regulation of gamma-delta T cell activation (GO:0046645)4.17452020
15negative regulation of cell killing (GO:0031342)4.09973409
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.09973409
17modulation by symbiont of host defense response (GO:0052031)4.04179982
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.04179982
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.04179982
20positive regulation by organism of defense response of other organism involved in symbiotic interact4.04179982
21modulation by symbiont of host immune response (GO:0052553)4.04179982
22positive regulation by symbiont of host defense response (GO:0052509)4.04179982
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.03593622
24antigen processing and presentation of endogenous antigen (GO:0019883)4.00649781
25negative regulation of erythrocyte differentiation (GO:0045647)3.95732422
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.95223861
27acrosome assembly (GO:0001675)3.88360809
28regulation of cilium movement (GO:0003352)3.87306394
29sperm-egg recognition (GO:0035036)3.83694748
30NIK/NF-kappaB signaling (GO:0038061)3.82098020
31negative regulation of inclusion body assembly (GO:0090084)3.81879710
32cilium movement (GO:0003341)3.81795497
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.78889487
34reproduction (GO:0000003)3.75421459
35neutrophil activation involved in immune response (GO:0002283)3.69696567
36spermatid development (GO:0007286)3.60172845
37macrophage activation involved in immune response (GO:0002281)3.57527103
38immunoglobulin mediated immune response (GO:0016064)3.51001785
39sperm capacitation (GO:0048240)3.46437424
40cell-cell recognition (GO:0009988)3.45673148
41mannose metabolic process (GO:0006013)3.45473578
42detection of other organism (GO:0098543)3.41783023
43detection of bacterium (GO:0016045)3.40629764
44regulation of interferon-beta biosynthetic process (GO:0045357)3.40412120
45protein localization to cilium (GO:0061512)3.39293056
46epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.35993243
47negative regulation of interleukin-12 production (GO:0032695)3.35090839
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34455610
49synaptic vesicle exocytosis (GO:0016079)3.31330322
50negative regulation of phagocytosis (GO:0050765)3.31073186
51regulation of B cell receptor signaling pathway (GO:0050855)3.26966544
52single fertilization (GO:0007338)3.26194865
53cellular response to type I interferon (GO:0071357)3.26108551
54type I interferon signaling pathway (GO:0060337)3.26108551
55response to type I interferon (GO:0034340)3.24163844
56ATP hydrolysis coupled proton transport (GO:0015991)3.15781521
57energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.15781521
58binding of sperm to zona pellucida (GO:0007339)3.15662898
59positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12412620
60response to host immune response (GO:0052572)3.09288169
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.09288169
62respiratory burst (GO:0045730)3.02612775
63regulation of inclusion body assembly (GO:0090083)3.02131781
64presynaptic membrane assembly (GO:0097105)3.02073954
65response to muramyl dipeptide (GO:0032495)2.99910167
66positive thymic T cell selection (GO:0045059)2.97183699
67leukocyte aggregation (GO:0070486)2.95763078
68response to host (GO:0075136)2.95257941
69response to host defenses (GO:0052200)2.95257941
70response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.95257941
71lipopolysaccharide-mediated signaling pathway (GO:0031663)2.95021434
72regulation of gamma-delta T cell activation (GO:0046643)2.95005072
73regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.93776233
74B cell receptor signaling pathway (GO:0050853)2.93432765
75neuronal action potential propagation (GO:0019227)2.93068672
76detection of external biotic stimulus (GO:0098581)2.92167650
77regulation of microtubule-based movement (GO:0060632)2.90012802
78regulation of mast cell degranulation (GO:0043304)2.89044890
79pinocytosis (GO:0006907)2.86148929
80glutamate secretion (GO:0014047)2.86034705
81modulation by symbiont of host cellular process (GO:0044068)2.85074917
82regulation of protein kinase A signaling (GO:0010738)2.83344093
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.82845503
84positive regulation of B cell differentiation (GO:0045579)2.81963116
85mature B cell differentiation involved in immune response (GO:0002313)2.81034648
86regulation of short-term neuronal synaptic plasticity (GO:0048172)2.80602017
87regulation of leukocyte degranulation (GO:0043300)2.79828659
88piRNA metabolic process (GO:0034587)2.79570929
89regulation of antigen processing and presentation (GO:0002577)2.79089352
90regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.78842792
91negative regulation of innate immune response (GO:0045824)2.78688650
92organic cation transport (GO:0015695)2.77327139
93negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.77322377
94positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.77044699
95interferon-gamma-mediated signaling pathway (GO:0060333)2.75683855
96GDP-mannose metabolic process (GO:0019673)2.75357054
97regulation of synaptic vesicle exocytosis (GO:2000300)2.75179661
98vocalization behavior (GO:0071625)2.72859389
99regulation of dendritic cell antigen processing and presentation (GO:0002604)2.71508011
100negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.71081952
101regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70011604
102presynaptic membrane organization (GO:0097090)2.66950482
103myeloid dendritic cell differentiation (GO:0043011)2.66154706
104positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.66086244
105glycosphingolipid catabolic process (GO:0046479)2.65699687
106myeloid cell activation involved in immune response (GO:0002275)2.65566945
107germinal center formation (GO:0002467)2.65466445
108left/right pattern formation (GO:0060972)2.64568969
109detection of molecule of bacterial origin (GO:0032490)2.63542955
110regulation of myeloid leukocyte mediated immunity (GO:0002886)2.63420405
111thymic T cell selection (GO:0045061)2.63094574
112modulation by virus of host process (GO:0019054)2.61916760
113cellular extravasation (GO:0045123)2.61268621
114protein localization to synapse (GO:0035418)2.58787351
115myeloid dendritic cell activation (GO:0001773)2.58111977
116neuromuscular process controlling posture (GO:0050884)2.57540018
117B cell mediated immunity (GO:0019724)2.56953690
118response to dietary excess (GO:0002021)2.54278956
119regulation of gamma-delta T cell differentiation (GO:0045586)2.53926510
120positive regulation of antigen processing and presentation (GO:0002579)2.53667434
121negative regulation of leukocyte mediated immunity (GO:0002704)2.53486031
122negative regulation of myeloid cell apoptotic process (GO:0033033)2.53444514
123positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.52317974
124male meiosis (GO:0007140)2.52033333
125positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.52021345
126regulation of mast cell activation involved in immune response (GO:0033006)2.50971787
127response to protozoan (GO:0001562)2.50960543
128fertilization (GO:0009566)2.50923193
129Arp2/3 complex-mediated actin nucleation (GO:0034314)2.50818786
130regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.50684213
131negative regulation of amino acid transport (GO:0051956)2.50616545
132fatty acid elongation (GO:0030497)2.50583948
133detection of biotic stimulus (GO:0009595)2.50422709
134negative regulation of lymphocyte mediated immunity (GO:0002707)2.49820689
135cellular response to epinephrine stimulus (GO:0071872)2.49297617
136defense response to protozoan (GO:0042832)2.49089605
137antigen processing and presentation via MHC class Ib (GO:0002475)2.48748916
138response to acidic pH (GO:0010447)2.48276132
139amino sugar catabolic process (GO:0046348)2.48014960
140regulation of superoxide anion generation (GO:0032928)2.47586430
141negative regulation of cytokine production involved in immune response (GO:0002719)2.47515862
142T cell selection (GO:0045058)2.47375167
143glycolipid catabolic process (GO:0019377)2.46493578
144negative regulation of T cell mediated immunity (GO:0002710)2.45503408
145negative regulation of interleukin-6 production (GO:0032715)2.44666017
146positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.43057104
147regulation of synaptic vesicle transport (GO:1902803)2.42580111
148neuron cell-cell adhesion (GO:0007158)2.42472143
149negative regulation of neurotransmitter transport (GO:0051589)2.42453803
150membrane depolarization during action potential (GO:0086010)2.42098212
151microtubule severing (GO:0051013)2.42029871
152negative thymic T cell selection (GO:0045060)2.41741217
153T-helper 1 type immune response (GO:0042088)2.41455885
154negative regulation of synaptic transmission, GABAergic (GO:0032229)2.41084706
155synaptic vesicle maturation (GO:0016188)2.40176775
156protein localization to endosome (GO:0036010)2.40108867
157macrophage activation (GO:0042116)2.39824028
158positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.39601471
159T cell migration (GO:0072678)2.39057690
160positive regulation of tumor necrosis factor production (GO:0032760)2.38700439
161ionotropic glutamate receptor signaling pathway (GO:0035235)2.38169275
162response to epinephrine (GO:0071871)2.38055441
163positive regulation of interferon-alpha production (GO:0032727)2.37200918
164ventricular system development (GO:0021591)2.36335388
165neurotransmitter secretion (GO:0007269)2.35122576
166response to methylmercury (GO:0051597)2.35092311
167hydrogen ion transmembrane transport (GO:1902600)2.34958245
168regulation of glutamate secretion (GO:0014048)2.33831849
169regulation of vesicle fusion (GO:0031338)2.31629196
170gamma-aminobutyric acid transport (GO:0015812)2.31139766
171transferrin transport (GO:0033572)2.30830675
172triglyceride catabolic process (GO:0019433)2.29292353
173glycerol metabolic process (GO:0006071)2.29007495
174electron transport chain (GO:0022900)2.27706253
175respiratory electron transport chain (GO:0022904)2.27628143
176negative regulation of neurotransmitter secretion (GO:0046929)2.25493527
177postsynaptic membrane organization (GO:0001941)2.24271914
178detection of calcium ion (GO:0005513)2.24098872
179proline transport (GO:0015824)2.23183148
180ferric iron transport (GO:0015682)2.22881815
181trivalent inorganic cation transport (GO:0072512)2.22881815
182long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.21472588
183long-chain fatty acid biosynthetic process (GO:0042759)2.20517149
184acylglycerol catabolic process (GO:0046464)2.20282945
185neutral lipid catabolic process (GO:0046461)2.20282945
186glycerol ether metabolic process (GO:0006662)2.19989601
187membrane assembly (GO:0071709)2.19184731
188alditol metabolic process (GO:0019400)2.18275197
189regulation of glutamate receptor signaling pathway (GO:1900449)2.18265878
190proton transport (GO:0015992)2.17730719
191transmission of nerve impulse (GO:0019226)2.17288205
192cell recognition (GO:0008037)2.17037361
193calcium ion import (GO:0070509)2.16641571
194phagosome maturation (GO:0090382)2.16295433
195mitochondrion degradation (GO:0000422)2.15652277
196glutamate receptor signaling pathway (GO:0007215)2.14783782
197hydrogen transport (GO:0006818)2.14535907
198fatty-acyl-CoA metabolic process (GO:0035337)2.12731636
199synaptonemal complex organization (GO:0070193)2.11810277
200mating behavior (GO:0007617)2.10421919

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.27328824
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.72238265
3VDR_21846776_ChIP-Seq_THP-1_Human3.47764850
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.98632874
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.76909472
6MYC_22102868_ChIP-Seq_BL_Human2.61331104
7* LXR_22292898_ChIP-Seq_THP-1_Human2.53493996
8VDR_24763502_ChIP-Seq_THP-1_Human2.47489638
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.45835844
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.28141497
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.19336061
12MAF_26560356_Chip-Seq_TH1_Human2.14675515
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10321146
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09126530
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08722005
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06346710
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04328782
18* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03231264
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03175204
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01795077
21REST_21632747_ChIP-Seq_MESCs_Mouse2.01025437
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.99911583
23GBX2_23144817_ChIP-Seq_PC3_Human1.92552445
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91750004
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91645314
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90999842
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90638697
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.90104326
29UTX_26944678_Chip-Seq_JUKART_Human1.85543885
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.84427932
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.84194250
32TCF7_22412390_ChIP-Seq_EML_Mouse1.82953974
33MAF_26560356_Chip-Seq_TH2_Human1.82165996
34KDM2B_26808549_Chip-Seq_DND41_Human1.81481264
35TAF15_26573619_Chip-Seq_HEK293_Human1.81017131
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.80747728
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80367482
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78078786
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.77805383
40RACK7_27058665_Chip-Seq_MCF-7_Human1.77239964
41SPI1_23547873_ChIP-Seq_NB4_Human1.77075031
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.74593892
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.74266136
44DROSHA_22980978_ChIP-Seq_HELA_Human1.74076919
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73008123
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70746217
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68905415
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66088657
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.65732992
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63999026
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62920403
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.62899989
53SPI1_23127762_ChIP-Seq_K562_Human1.60697619
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60514254
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58888886
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.57899338
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54547266
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54270457
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54270457
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54086048
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.51561712
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51073380
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50991177
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50952845
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.50816761
66VDR_22108803_ChIP-Seq_LS180_Human1.50200904
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.49482862
68RARB_27405468_Chip-Seq_BRAIN_Mouse1.48883038
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45732053
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44534224
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44184588
72SCL_19346495_ChIP-Seq_HPC-7_Human1.44042383
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43278377
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43173892
75P68_20966046_ChIP-Seq_HELA_Human1.41616499
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.41219869
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40605294
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40576180
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.39907023
80BCOR_27268052_Chip-Seq_Bcells_Human1.39690465
81BCL6_27268052_Chip-Seq_Bcells_Human1.39597170
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39462997
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38645204
84EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36165409
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34819657
86MYB_26560356_Chip-Seq_TH1_Human1.34705433
87ZNF274_21170338_ChIP-Seq_K562_Hela1.34631459
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.31048994
89PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30645295
90TET1_21451524_ChIP-Seq_MESCs_Mouse1.30166960
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28995672
92MYB_26560356_Chip-Seq_TH2_Human1.28611222
93* NCOR1_26117541_ChIP-Seq_K562_Human1.28271612
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27893209
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25020407
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.23810242
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23067831
98GATA1_19941827_ChIP-Seq_MEL_Mouse1.21646772
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20913889
100ZNF263_19887448_ChIP-Seq_K562_Human1.20778064
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20354680
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19976516
103SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19379384
104* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18216595
105TFEB_21752829_ChIP-Seq_HELA_Human1.18096164
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17614361
107* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17452026
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17119456
109ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16682226
110GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15352804
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15163874
112EED_16625203_ChIP-ChIP_MESCs_Mouse1.15090656
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14087958
114TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13976602
115ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13508469
116STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12315147
117GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11779504
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11164182
119FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09277322
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09088406
121CTCF_26484167_Chip-Seq_Bcells_Mouse1.08325021
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08018827
123* RXR_22158963_ChIP-Seq_LIVER_Mouse1.06602360
124ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06318663
125FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05903604
126GATA1_19941826_ChIP-Seq_K562_Human1.05859192
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05794585
128KDM2B_26808549_Chip-Seq_JURKAT_Human1.05647545
129GATA1_22025678_ChIP-Seq_K562_Human1.05447398
130* SMC4_20622854_ChIP-Seq_HELA_Human1.04676765
131CBX2_27304074_Chip-Seq_ESCs_Mouse1.04458937
132RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04304698
133KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04260278
134SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04258190
135RUNX_20019798_ChIP-Seq_JUKART_Human1.03921879
136Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02903686
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02192987
138RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01749167
139CBP_20019798_ChIP-Seq_JUKART_Human1.01578874
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01578874
141SMAD4_21799915_ChIP-Seq_A2780_Human1.01324469
142* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00003140
143CTCF_27219007_Chip-Seq_Bcells_Human0.98311037
144FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98034967
145KDM2B_26808549_Chip-Seq_REH_Human0.97297083
146SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92893680
147TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92819338
148RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92082439
149ELK4_26923725_Chip-Seq_MESODERM_Mouse0.91340764
150FLI1_21867929_ChIP-Seq_TH2_Mouse0.90637093
151ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90614210
152* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89705651
153ER_23166858_ChIP-Seq_MCF-7_Human0.87760689
154TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87656745
155BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86915373
156AR_25329375_ChIP-Seq_VCAP_Human0.85531612
157PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84286510
158NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83716575
159CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.83662308
160TAL1_26923725_Chip-Seq_HPCs_Mouse0.82062201
161GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.81729418
162PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81594375
163BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81481919
164CTCF_20526341_ChIP-Seq_ESCs_Human0.81220678
165* SMAD3_21741376_ChIP-Seq_EPCs_Human0.80568514
166TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80506096
167P300_19829295_ChIP-Seq_ESCs_Human0.80118199
168UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79634278
169P53_21459846_ChIP-Seq_SAOS-2_Human0.77513649
170ERG_21242973_ChIP-ChIP_JURKAT_Human0.76571774
171PIAS1_25552417_ChIP-Seq_VCAP_Human0.76548727
172PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.76431472
173GATA3_21867929_ChIP-Seq_TH1_Mouse0.76220998
174SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74354225
175VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.74047056
176MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.73577762
177TOP2B_26459242_ChIP-Seq_MCF-7_Human0.73286370
178* SMAD4_21741376_ChIP-Seq_EPCs_Human0.73283504
179ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.72881261
180AR_21572438_ChIP-Seq_LNCaP_Human0.72878999
181SMAD3_21741376_ChIP-Seq_ESCs_Human0.72803031
182TCF4_23295773_ChIP-Seq_U87_Human0.72394558
183TET1_21490601_ChIP-Seq_MESCs_Mouse0.71502131
184RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.70662285
185JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.70425757
186RING1B_27294783_Chip-Seq_ESCs_Mouse0.70399695
187SOX2_22085726_ChIP-Seq_NPCs_Mouse0.70006291
188KLF4_19829295_ChIP-Seq_ESCs_Human0.69957698
189THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.69717921
190DNAJC2_21179169_ChIP-ChIP_NT2_Human0.69258223
191BCAT_22108803_ChIP-Seq_LS180_Human0.69201185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.79300514
2MP0004859_abnormal_synaptic_plasticity3.36361631
3MP0003880_abnormal_central_pattern3.26864642
4MP0003303_peritoneal_inflammation3.26536911
5MP0003436_decreased_susceptibility_to3.20775035
6MP0005451_abnormal_body_composition3.08553999
7MP0003172_abnormal_lysosome_physiology3.03542223
8MP0001835_abnormal_antigen_presentation2.93069421
9MP0009840_abnormal_foam_cell2.87538901
10MP0003329_amyloid_beta_deposits2.76288437
11MP0000685_abnormal_immune_system2.67773691
12MP0001790_abnormal_immune_system2.51846958
13MP0005387_immune_system_phenotype2.51846958
14MP0003300_gastrointestinal_ulcer2.49432558
15MP0004270_analgesia2.47302596
16MP0003635_abnormal_synaptic_transmissio2.46919305
17MP0005025_abnormal_response_to2.44742772
18MP0002419_abnormal_innate_immunity2.43434122
19MP0005000_abnormal_immune_tolerance2.39826646
20MP0001968_abnormal_touch/_nociception2.39663654
21MP0009745_abnormal_behavioral_response2.35500243
22MP0002064_seizures2.31880439
23MP0006082_CNS_inflammation2.30526276
24MP0002822_catalepsy2.30294504
25MP0009046_muscle_twitch2.29651539
26MP0009785_altered_susceptibility_to2.22625271
27MP0002837_dystrophic_cardiac_calcinosis2.22480668
28MP0001501_abnormal_sleep_pattern2.21678414
29MP0005670_abnormal_white_adipose2.21459819
30MP0001800_abnormal_humoral_immune2.19760720
31MP0006276_abnormal_autonomic_nervous2.13445192
32MP0005671_abnormal_response_to2.12679113
33MP0002272_abnormal_nervous_system2.10623677
34MP0002148_abnormal_hypersensitivity_rea2.10401404
35MP0008260_abnormal_autophagy2.08871661
36MP0002452_abnormal_antigen_presenting2.06675215
37MP0002736_abnormal_nociception_after2.05929065
38MP0002723_abnormal_immune_serum2.04414808
39MP0002420_abnormal_adaptive_immunity1.98369067
40MP0001819_abnormal_immune_cell1.95890811
41MP0003698_abnormal_male_reproductive1.88142028
42MP0003763_abnormal_thymus_physiology1.88023482
43MP0005464_abnormal_platelet_physiology1.87860837
44MP0002063_abnormal_learning/memory/cond1.81568061
45MP0000920_abnormal_myelination1.80255858
46MP0004947_skin_inflammation1.78705407
47MP0002733_abnormal_thermal_nociception1.77686646
48MP0000604_amyloidosis1.75593115
49MP0002735_abnormal_chemical_nociception1.75486225
50MP0002572_abnormal_emotion/affect_behav1.75333677
51MP0009333_abnormal_splenocyte_physiolog1.74994707
52MP0001533_abnormal_skeleton_physiology1.73505711
53MP0001984_abnormal_olfaction1.73368657
54MP0001905_abnormal_dopamine_level1.71051606
55MP0003705_abnormal_hypodermis_morpholog1.70644782
56MP0004130_abnormal_muscle_cell1.66002991
57MP0002876_abnormal_thyroid_physiology1.65733532
58MP0009278_abnormal_bone_marrow1.64134684
59MP0001845_abnormal_inflammatory_respons1.64043368
60MP0010155_abnormal_intestine_physiology1.64001552
61MP0001440_abnormal_grooming_behavior1.63501136
62MP0000013_abnormal_adipose_tissue1.60279055
63MP0002405_respiratory_system_inflammati1.58246771
64MP0005397_hematopoietic_system_phenotyp1.57773674
65MP0001545_abnormal_hematopoietic_system1.57773674
66MP0005535_abnormal_body_temperature1.57672741
67MP0001486_abnormal_startle_reflex1.52978922
68MP0000716_abnormal_immune_system1.52560131
69MP0002398_abnormal_bone_marrow1.52488902
70MP0002734_abnormal_mechanical_nocicepti1.51328996
71MP0004142_abnormal_muscle_tone1.50909948
72MP0002067_abnormal_sensory_capabilities1.47528816
73MP0002909_abnormal_adrenal_gland1.45339332
74MP0008469_abnormal_protein_level1.44888394
75MP0001970_abnormal_pain_threshold1.43798108
76MP0000858_altered_metastatic_potential1.43518903
77MP0008438_abnormal_cutaneous_collagen1.38041707
78MP0003690_abnormal_glial_cell1.36111242
79MP0003646_muscle_fatigue1.35874372
80MP0003633_abnormal_nervous_system1.34624278
81MP0005310_abnormal_salivary_gland1.32555727
82MP0003806_abnormal_nucleotide_metabolis1.30784516
83MP0000689_abnormal_spleen_morphology1.30485345
84MP0005386_behavior/neurological_phenoty1.30176340
85MP0004924_abnormal_behavior1.30176340
86MP0002429_abnormal_blood_cell1.29212295
87MP0005423_abnormal_somatic_nervous1.28569372
88MP0002722_abnormal_immune_system1.27258422
89MP0008569_lethality_at_weaning1.26033731
90MP0005058_abnormal_lysosome_morphology1.25267847
91MP0001529_abnormal_vocalization1.25181272
92MP0003453_abnormal_keratinocyte_physiol1.24270791
93MP0002998_abnormal_bone_remodeling1.23630530
94MP0002132_abnormal_respiratory_system1.22994858
95MP0003879_abnormal_hair_cell1.20802699
96MP0001502_abnormal_circadian_rhythm1.20381594
97MP0000343_altered_response_to1.19938127
98MP0001873_stomach_inflammation1.19389962
99MP0010234_abnormal_vibrissa_follicle1.17124075
100MP0003191_abnormal_cellular_cholesterol1.16678030
101MP0008875_abnormal_xenobiotic_pharmacok1.15708805
102MP0001929_abnormal_gametogenesis1.15481816
103MP0003866_abnormal_defecation1.15447063
104MP0001853_heart_inflammation1.15441644
105MP0003279_aneurysm1.14449253
106MP0003656_abnormal_erythrocyte_physiolo1.11991452
107MP0002229_neurodegeneration1.11140761
108MP0002971_abnormal_brown_adipose1.10095981
109MP0005666_abnormal_adipose_tissue1.09531780
110MP0000015_abnormal_ear_pigmentation1.08805111
111MP0009780_abnormal_chondrocyte_physiolo1.08565934
112MP0003631_nervous_system_phenotype1.08426013
113MP0008874_decreased_physiological_sensi1.07642596
114MP0010329_abnormal_lipoprotein_level1.06978974
115MP0004381_abnormal_hair_follicle1.06504821
116MP0005584_abnormal_enzyme/coenzyme_acti1.05946930
117MP0003091_abnormal_cell_migration1.05915881
118MP0003183_abnormal_peptide_metabolism1.05849773
119MP0002118_abnormal_lipid_homeostasis1.05319383
120MP0004885_abnormal_endolymph1.05298495
121MP0002066_abnormal_motor_capabilities/c1.04613340
122MP0001765_abnormal_ion_homeostasis1.04355381
123MP0005166_decreased_susceptibility_to1.04220815
124MP0000751_myopathy1.01498596
125MP0003448_altered_tumor_morphology1.01102067
126MP0005645_abnormal_hypothalamus_physiol1.00844467
127MP0004742_abnormal_vestibular_system1.00331826
128MP0001849_ear_inflammation0.99792645
129MP0002166_altered_tumor_susceptibility0.99571343
130MP0003634_abnormal_glial_cell0.96936285
131MP0002557_abnormal_social/conspecific_i0.96732542
132MP0000703_abnormal_thymus_morphology0.95987939
133MP0000955_abnormal_spinal_cord0.95315926
134MP0005375_adipose_tissue_phenotype0.94916396
135MP0001958_emphysema0.93700490
136MP0000465_gastrointestinal_hemorrhage0.92419500
137MP0000490_abnormal_crypts_of0.92351237
138MP0004858_abnormal_nervous_system0.91940884
139MP0002877_abnormal_melanocyte_morpholog0.89769589
140MP0006036_abnormal_mitochondrial_physio0.89653962
141MP0003724_increased_susceptibility_to0.89561936
142MP0002161_abnormal_fertility/fecundity0.89166441
143MP0005623_abnormal_meninges_morphology0.88992096
144MP0002933_joint_inflammation0.88465906
145MP0003075_altered_response_to0.88154372
146MP0004185_abnormal_adipocyte_glucose0.87863020
147MP0005076_abnormal_cell_differentiation0.86477569
148MP0002139_abnormal_hepatobiliary_system0.85413689
149MP0003566_abnormal_cell_adhesion0.85313549
150MP0002882_abnormal_neuron_morphology0.85172118
151MP0004811_abnormal_neuron_physiology0.85096549
152MP0001986_abnormal_taste_sensitivity0.84072267
153MP0005551_abnormal_eye_electrophysiolog0.83992412
154MP0009764_decreased_sensitivity_to0.83950283
155MP0005164_abnormal_response_to0.82278255
156MP0005390_skeleton_phenotype0.81667080
157MP0002396_abnormal_hematopoietic_system0.80604597
158MP0003795_abnormal_bone_structure0.80498474
159MP0000003_abnormal_adipose_tissue0.80416328
160MP0005646_abnormal_pituitary_gland0.80129348
161MP0000230_abnormal_systemic_arterial0.80068788
162MP0002693_abnormal_pancreas_physiology0.79812143
163MP0004883_abnormal_blood_vessel0.78438727
164MP0000609_abnormal_liver_physiology0.77974159
165MP0004036_abnormal_muscle_relaxation0.77403979
166MP0005365_abnormal_bile_salt0.77283557
167MP0004808_abnormal_hematopoietic_stem0.75961020
168MP0002184_abnormal_innervation0.75282392
169MP0005636_abnormal_mineral_homeostasis0.75211435
170MP0005084_abnormal_gallbladder_morpholo0.74077857
171MP0009763_increased_sensitivity_to0.73811564
172MP0002295_abnormal_pulmonary_circulatio0.73791321
173MP0001851_eye_inflammation0.72142150
174MP0004043_abnormal_pH_regulation0.72022261
175MP0005319_abnormal_enzyme/_coenzyme0.71939535
176MP0002638_abnormal_pupillary_reflex0.71797119
177MP0005075_abnormal_melanosome_morpholog0.71791624
178MP0003959_abnormal_lean_body0.71066787
179MP0009643_abnormal_urine_homeostasis0.70551396
180MP0002069_abnormal_eating/drinking_beha0.70469383
181MP0003632_abnormal_nervous_system0.69957931
182MP0005334_abnormal_fat_pad0.69701028
183MP0008004_abnormal_stomach_pH0.69459953
184MP0005023_abnormal_wound_healing0.68736758
185MP0004510_myositis0.68532652
186MP0001664_abnormal_digestion0.67599719
187MP0001542_abnormal_bone_strength0.67211861
188MP0002138_abnormal_hepatobiliary_system0.67063351
189MP0001963_abnormal_hearing_physiology0.66389270
190MP0010386_abnormal_urinary_bladder0.63028215

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)7.20219093
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.20219093
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.24040457
4Abnormal respiratory motile cilium physiology (HP:0012261)4.95696429
5Abnormal respiratory epithelium morphology (HP:0012253)4.84522159
6Abnormal respiratory motile cilium morphology (HP:0005938)4.84522159
7Eczematoid dermatitis (HP:0000976)4.52742529
8Abnormal ciliary motility (HP:0012262)4.26858725
9Abnormality of glycolipid metabolism (HP:0010969)4.25502373
10Abnormality of liposaccharide metabolism (HP:0010968)4.25502373
11Abnormality of glycosphingolipid metabolism (HP:0004343)4.25502373
12Abnormality of macrophages (HP:0004311)4.23381149
13Rhinitis (HP:0012384)4.13107773
14Recurrent abscess formation (HP:0002722)4.07558003
15Neurofibrillary tangles (HP:0002185)4.06748269
16Recurrent bacterial skin infections (HP:0005406)3.98533022
17Nasal polyposis (HP:0100582)3.58930749
18Infertility (HP:0000789)3.48142717
19Supranuclear gaze palsy (HP:0000605)3.38995865
20Cerebral inclusion bodies (HP:0100314)3.30968445
21Chronic bronchitis (HP:0004469)3.30528182
22Abnormality of mucopolysaccharide metabolism (HP:0011020)3.29243001
23Abnormality of polysaccharide metabolism (HP:0011012)3.29243001
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.29243001
25Mucopolysacchariduria (HP:0008155)3.27852035
26Urinary glycosaminoglycan excretion (HP:0003541)3.27852035
27Obstructive lung disease (HP:0006536)3.26990133
28Chronic obstructive pulmonary disease (HP:0006510)3.26990133
29Petechiae (HP:0000967)3.26252268
30Myokymia (HP:0002411)3.17930695
31Elevated erythrocyte sedimentation rate (HP:0003565)3.13194751
32Mediastinal lymphadenopathy (HP:0100721)3.08180505
33Focal motor seizures (HP:0011153)3.07463920
34Cellulitis (HP:0100658)3.06825943
35Recurrent gram-negative bacterial infections (HP:0005420)3.03355633
36Abnormality of the nasal mucosa (HP:0000433)3.01971206
37Myositis (HP:0100614)3.00592183
38Retinal dysplasia (HP:0007973)2.99769676
39Abnormal gallbladder physiology (HP:0012438)2.94117037
40Cholecystitis (HP:0001082)2.94117037
41Meningitis (HP:0001287)2.86529046
42Purpura (HP:0000979)2.81869788
43Vertebral compression fractures (HP:0002953)2.78136168
44Sensory axonal neuropathy (HP:0003390)2.74619337
45Progressive inability to walk (HP:0002505)2.73767281
46Recurrent skin infections (HP:0001581)2.73094166
47Systemic lupus erythematosus (HP:0002725)2.70599725
48Recurrent fungal infections (HP:0002841)2.68220910
49Atonic seizures (HP:0010819)2.67254835
50Increased IgE level (HP:0003212)2.65771181
51Acute necrotizing encephalopathy (HP:0006965)2.62821875
52Gastrointestinal infarctions (HP:0005244)2.61123933
53Oligomenorrhea (HP:0000876)2.57900821
54Epileptic encephalopathy (HP:0200134)2.55221913
55Visual hallucinations (HP:0002367)2.55078887
56Spontaneous hematomas (HP:0007420)2.52798007
57Gingivitis (HP:0000230)2.49809486
58Abnormal mitochondria in muscle tissue (HP:0008316)2.49259266
59Progressive neurologic deterioration (HP:0002344)2.47295704
60Recurrent viral infections (HP:0004429)2.45360678
61Gastrointestinal stroma tumor (HP:0100723)2.43900577
62Hypertensive crisis (HP:0100735)2.42516360
63Vasculitis (HP:0002633)2.42276107
64Orchitis (HP:0100796)2.41261027
65Mitochondrial inheritance (HP:0001427)2.38984388
66Bronchiectasis (HP:0002110)2.38386046
67Type II lissencephaly (HP:0007260)2.36750082
68Medial flaring of the eyebrow (HP:0010747)2.35513579
69Hepatocellular necrosis (HP:0001404)2.35094679
70Focal seizures (HP:0007359)2.33951340
71Colitis (HP:0002583)2.33643166
72Acute encephalopathy (HP:0006846)2.33496779
73Increased serum ferritin (HP:0003281)2.30160583
74Recurrent cutaneous fungal infections (HP:0011370)2.28535545
75Chronic mucocutaneous candidiasis (HP:0002728)2.28535545
76Hepatosplenomegaly (HP:0001433)2.28526274
77Thin bony cortex (HP:0002753)2.27608580
78J-shaped sella turcica (HP:0002680)2.27347743
79Progressive macrocephaly (HP:0004481)2.25796107
80Pheochromocytoma (HP:0002666)2.23408504
81Urticaria (HP:0001025)2.23366794
82Osteomyelitis (HP:0002754)2.23172508
83Agammaglobulinemia (HP:0004432)2.22685390
84Abnormal delayed hypersensitivity skin test (HP:0002963)2.22401356
85Gastrointestinal inflammation (HP:0004386)2.21995043
86Interstitial pulmonary disease (HP:0006530)2.21445053
87Stomatitis (HP:0010280)2.19207521
88Prolonged neonatal jaundice (HP:0006579)2.19200805
89Increased muscle lipid content (HP:0009058)2.18861569
90Thrombocytosis (HP:0001894)2.17935818
91Hyperventilation (HP:0002883)2.16427382
92Hypergammaglobulinemia (HP:0010702)2.15441252
93Inflammation of the large intestine (HP:0002037)2.14832570
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11897079
95Bronchitis (HP:0012387)2.11530898
96Epistaxis (HP:0000421)2.11468531
97Emphysema (HP:0002097)2.11466098
98Pulmonary infiltrates (HP:0002113)2.10905225
99Exercise-induced myalgia (HP:0003738)2.06194036
100Neuroendocrine neoplasm (HP:0100634)2.06077660
101Joint stiffness (HP:0001387)2.04248351
102Retrobulbar optic neuritis (HP:0100654)2.01068803
103Optic neuritis (HP:0100653)2.01068803
104Hemiparesis (HP:0001269)2.01006784
105Asymmetric septal hypertrophy (HP:0001670)2.00324375
106Hepatic necrosis (HP:0002605)2.00290510
107Cerebral hemorrhage (HP:0001342)1.99195457
108Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.98957401
109Abnormal eating behavior (HP:0100738)1.98616810
110Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95667871
111Degeneration of the lateral corticospinal tracts (HP:0002314)1.95667871
112Cervical subluxation (HP:0003308)1.93444298
113Inability to walk (HP:0002540)1.93386015
114Spondylolisthesis (HP:0003302)1.91477115
115Prolonged bleeding time (HP:0003010)1.90921234
116Increased CSF lactate (HP:0002490)1.90714377
117Malnutrition (HP:0004395)1.89966712
118Nephronophthisis (HP:0000090)1.89721396
119Loss of speech (HP:0002371)1.89705803
120Increased IgM level (HP:0003496)1.89600186
121Abnormal pupillary function (HP:0007686)1.89305442
122Lymphopenia (HP:0001888)1.88616899
123Encephalitis (HP:0002383)1.87617545
124Dysmetria (HP:0001310)1.87391567
125Increased intramyocellular lipid droplets (HP:0012240)1.87304682
126Tubulointerstitial nephritis (HP:0001970)1.87183944
127Absence seizures (HP:0002121)1.86422996
128Nuclear cataract (HP:0100018)1.86170255
129Gait imbalance (HP:0002141)1.85168928
130Restrictive lung disease (HP:0002091)1.84831469
131Amyloidosis (HP:0011034)1.84111248
132Pustule (HP:0200039)1.83657047
133Hemoptysis (HP:0002105)1.82941119
134Abnormality of saccadic eye movements (HP:0000570)1.82123169
135Gingival bleeding (HP:0000225)1.81342300
136Acute hepatic failure (HP:0006554)1.81092326
137Skin ulcer (HP:0200042)1.80559327
138Abnormality of aromatic amino acid family metabolism (HP:0004338)1.80291001
139Abnormality of iron homeostasis (HP:0011031)1.79133721
140Renal Fanconi syndrome (HP:0001994)1.78314945
141Chest pain (HP:0100749)1.77614306
142Optic disc pallor (HP:0000543)1.76472012
143Polyphagia (HP:0002591)1.74748103
144Increased neuronal autofluorescent lipopigment (HP:0002074)1.74548747
145Premature loss of primary teeth (HP:0006323)1.74504502
146Abnormality of cells of the lymphoid lineage (HP:0012140)1.74002956
147Abnormality of renal resorption (HP:0011038)1.73621982
148Vacuolated lymphocytes (HP:0001922)1.73197229
149Neuronal loss in central nervous system (HP:0002529)1.72776410
150Dialeptic seizures (HP:0011146)1.72746487
151Generalized tonic-clonic seizures (HP:0002069)1.72282298
152Granulocytopenia (HP:0001913)1.71612086
153Congenital primary aphakia (HP:0007707)1.71483290
154Anxiety (HP:0000739)1.71451924
155Bone pain (HP:0002653)1.70725600
156Poor suck (HP:0002033)1.69417426
157Polygenic inheritance (HP:0010982)1.69192696
158Cerebral edema (HP:0002181)1.68474106
159Increased cerebral lipofuscin (HP:0011813)1.67818525
160Intention tremor (HP:0002080)1.67330427
161Episodic fever (HP:0001954)1.66920196
162Splenomegaly (HP:0001744)1.66671859
163Recurrent lower respiratory tract infections (HP:0002783)1.66240216
164Broad face (HP:0000283)1.66112711
165Lactic acidosis (HP:0003128)1.65996343
166Recurrent pneumonia (HP:0006532)1.65889211
167Sepsis (HP:0100806)1.65862326
168Papilloma (HP:0012740)1.64519202
169Verrucae (HP:0200043)1.64519202
170Thoracic kyphosis (HP:0002942)1.64483324
171Abnormality of the vitreous humor (HP:0004327)1.63871970
172Hypothermia (HP:0002045)1.62744570
173Hemorrhage of the eye (HP:0011885)1.61924291
174Gaze-evoked nystagmus (HP:0000640)1.61132592
175Clumsiness (HP:0002312)1.60391825
176Delayed gross motor development (HP:0002194)1.60212071
177Amblyopia (HP:0000646)1.59774924
178Spastic gait (HP:0002064)1.58915824
179Ankle clonus (HP:0011448)1.58249544
180Respiratory failure (HP:0002878)1.58177923
181Myoglobinuria (HP:0002913)1.58028307
182Ketosis (HP:0001946)1.57265319
183Progressive cerebellar ataxia (HP:0002073)1.54974800
184Retinal atrophy (HP:0001105)1.54538297
185Delusions (HP:0000746)1.53528382
186Akinesia (HP:0002304)1.52438840
187Dysostosis multiplex (HP:0000943)1.51590286
188Leukodystrophy (HP:0002415)1.51185451
189Recurrent sinusitis (HP:0011108)1.50245304
190Truncal ataxia (HP:0002078)1.50127563
191Methylmalonic aciduria (HP:0012120)1.49457059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK43.62916876
2PDK33.62916876
3MAP4K13.13125029
4STK393.12450334
5NME23.10879373
6TRIB32.94601325
7CDK192.92275020
8PRKD32.88238441
9TESK12.75409868
10WNK42.57373853
11MAP3K122.42723507
12MAP2K32.41430593
13TYK22.29325526
14TNIK2.27186182
15TESK22.27145621
16NTRK32.27120404
17RIPK42.23518138
18SMG12.15251596
19TBK12.10186078
20IRAK42.05107787
21PDK22.04815879
22ICK2.03241521
23IRAK32.02261077
24PTK2B1.97044190
25DAPK21.80868092
26OXSR11.80150620
27PNCK1.77629202
28MAP3K141.68861962
29ARAF1.67473190
30SIK11.65927787
31GRK61.64420123
32MAP3K91.64201882
33ZAP701.61880847
34PAK61.59738012
35MAP3K41.58033544
36EPHA41.56906884
37MAP2K71.56469114
38NTRK11.56129071
39IKBKE1.49941174
40CAMKK21.47835511
41CSK1.45589358
42MAP3K31.44463018
43JAK31.40879754
44MINK11.38461709
45MAP2K41.38409831
46TAOK21.36099809
47CASK1.34787488
48GRK51.29167288
49BTK1.26813725
50CAMK1G1.24239412
51BCKDK1.23259662
52MAP3K131.22367360
53PKN21.20539905
54WNK11.20161082
55KSR21.20097275
56EPHB11.19957838
57PIM21.16538917
58IKBKB1.15241799
59JAK11.14842137
60KDR1.13412850
61CSF1R1.10942485
62MAPK151.06135947
63PRPF4B1.04209257
64FES0.99647580
65PDPK10.97433434
66HCK0.96869777
67CDK50.96716546
68FGFR40.96227632
69DAPK30.95786626
70TAOK10.94944559
71PDK10.93562470
72MAPKAPK50.92105206
73MAP3K20.91552287
74LYN0.89515541
75IRAK20.86800276
76KIT0.86549745
77CAMK2A0.85484109
78MUSK0.85441854
79NME10.85134863
80MAP3K10.84105346
81BRAF0.81289031
82LIMK10.81198257
83MAP3K60.81120030
84CDC42BPA0.81014685
85LRRK20.80242683
86CAMKK10.79376144
87CAMK10.78578266
88TGFBR20.78057082
89PAK40.77361261
90LCK0.76632977
91MST1R0.76626735
92HIPK20.76289865
93STK380.74957881
94MYLK0.74919823
95PRKCG0.72963796
96CDK120.71080038
97PTK60.70154502
98LMTK20.69745538
99DAPK10.69484806
100PAK30.66535879
101CAMK2G0.66272257
102IRAK10.66136253
103ITK0.65819327
104CAMK2B0.65693629
105EEF2K0.65482652
106ADRBK20.65452739
107MAPK110.64486009
108SIK20.64223194
109CAMK2D0.63094580
110JAK20.62200735
111MAP2K10.61378614
112BMPR20.61281232
113BLK0.60474544
114RPS6KA20.59789938
115CDK140.59085671
116SIK30.58930050
117BMX0.58666556
118TRIM280.58542319
119MAPK120.58525227
120MAPKAPK30.58095149
121RPS6KL10.57709278
122RPS6KC10.57709278
123TTN0.57581390
124PLK20.57383986
125NEK90.56081983
126STK110.55983082
127SCYL20.55867798
128DDR20.55340065
129ERN10.54665332
130FGFR30.53565823
131GRK70.53225298
132MATK0.52134369
133PKN10.51628061
134PHKG10.51099604
135PHKG20.51099604
136NTRK20.50455605
137MARK20.50070731
138RIPK10.49651350
139ROCK20.48916859
140MAP3K80.48455412
141ABL20.46827436
142PRKCE0.46481865
143MOS0.45819184
144ADRBK10.45526605
145CSNK1G20.45403438
146CDK150.45300268
147CAMK1D0.44138498
148STK100.43078294
149CDK11A0.42921585
150PRKCH0.42649178
151FGR0.42435500
152MAPKAPK20.42394418
153CDK180.42059294
154MAP2K20.41874560
155PRKG20.40851189
156PRKCQ0.40790621
157TRPM70.40615967
158CHUK0.40466822
159DYRK1B0.40257810
160INSRR0.39917624
161MAP2K60.39601022
162RPS6KA60.38854312
163UHMK10.38694900
164TYRO30.38214029
165TEC0.37782904
166CSNK1G30.34855579
167MAP3K110.33862283
168FYN0.33163784
169TNK20.32328890
170SYK0.31991786
171PRKD20.30376985
172CCNB10.29344322

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.73958957
2Oxidative phosphorylation_Homo sapiens_hsa001902.82158330
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.74909971
4Synaptic vesicle cycle_Homo sapiens_hsa047212.74224110
5Leishmaniasis_Homo sapiens_hsa051402.41228392
6Osteoclast differentiation_Homo sapiens_hsa043802.40397242
7Collecting duct acid secretion_Homo sapiens_hsa049662.39712167
8B cell receptor signaling pathway_Homo sapiens_hsa046622.26406679
9Allograft rejection_Homo sapiens_hsa053302.18250113
10Staphylococcus aureus infection_Homo sapiens_hsa051502.08414676
11Parkinsons disease_Homo sapiens_hsa050122.05724825
12Propanoate metabolism_Homo sapiens_hsa006402.01104450
13Alzheimers disease_Homo sapiens_hsa050101.99249990
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98972993
15Autoimmune thyroid disease_Homo sapiens_hsa053201.97076030
16Primary immunodeficiency_Homo sapiens_hsa053401.90996697
17Graft-versus-host disease_Homo sapiens_hsa053321.90574072
18Pyruvate metabolism_Homo sapiens_hsa006201.85068775
19Acute myeloid leukemia_Homo sapiens_hsa052211.81762851
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.80065172
21Tuberculosis_Homo sapiens_hsa051521.75724140
22Type I diabetes mellitus_Homo sapiens_hsa049401.74478449
23Cardiac muscle contraction_Homo sapiens_hsa042601.68191528
24Nicotine addiction_Homo sapiens_hsa050331.68089983
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.63997980
26Huntingtons disease_Homo sapiens_hsa050161.58900000
27Amphetamine addiction_Homo sapiens_hsa050311.56974846
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56224353
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53847606
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53040412
31Circadian entrainment_Homo sapiens_hsa047131.52405342
32Renin secretion_Homo sapiens_hsa049241.52187016
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.50705471
34Fatty acid elongation_Homo sapiens_hsa000621.50105426
35Vibrio cholerae infection_Homo sapiens_hsa051101.49978167
36GABAergic synapse_Homo sapiens_hsa047271.47508273
37Sulfur metabolism_Homo sapiens_hsa009201.45841994
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45586887
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44526024
40Influenza A_Homo sapiens_hsa051641.43150716
41Long-term potentiation_Homo sapiens_hsa047201.42972876
42Fatty acid biosynthesis_Homo sapiens_hsa000611.42543204
43Asthma_Homo sapiens_hsa053101.41962057
44Toxoplasmosis_Homo sapiens_hsa051451.41391550
45Measles_Homo sapiens_hsa051621.40965189
46Antigen processing and presentation_Homo sapiens_hsa046121.40839774
47Morphine addiction_Homo sapiens_hsa050321.38593629
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38501197
49Malaria_Homo sapiens_hsa051441.37629898
50Salivary secretion_Homo sapiens_hsa049701.37084418
51PPAR signaling pathway_Homo sapiens_hsa033201.33785011
52Glutamatergic synapse_Homo sapiens_hsa047241.32430162
53Hematopoietic cell lineage_Homo sapiens_hsa046401.29616597
54Hepatitis C_Homo sapiens_hsa051601.29159186
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28039417
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27123614
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24302493
58Serotonergic synapse_Homo sapiens_hsa047261.22410202
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22347232
60Herpes simplex infection_Homo sapiens_hsa051681.22100651
61Dopaminergic synapse_Homo sapiens_hsa047281.18628047
62Olfactory transduction_Homo sapiens_hsa047401.18463399
63Fatty acid metabolism_Homo sapiens_hsa012121.17397313
64TNF signaling pathway_Homo sapiens_hsa046681.16862521
65Viral myocarditis_Homo sapiens_hsa054161.16538187
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16218779
67Taste transduction_Homo sapiens_hsa047421.15269734
68T cell receptor signaling pathway_Homo sapiens_hsa046601.14193851
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13393316
70Insulin secretion_Homo sapiens_hsa049111.13236730
71Protein export_Homo sapiens_hsa030601.12524834
72Pertussis_Homo sapiens_hsa051331.12119036
73Cocaine addiction_Homo sapiens_hsa050301.11646136
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11602555
75Galactose metabolism_Homo sapiens_hsa000521.09909019
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09453044
77Glycerolipid metabolism_Homo sapiens_hsa005611.09369462
78Shigellosis_Homo sapiens_hsa051311.08072478
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07987282
80Non-small cell lung cancer_Homo sapiens_hsa052231.07008708
81Hepatitis B_Homo sapiens_hsa051611.06087528
82Fatty acid degradation_Homo sapiens_hsa000711.04728571
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04081862
84NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03921663
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03712452
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02022846
87Chronic myeloid leukemia_Homo sapiens_hsa052200.98767472
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96097001
89Salmonella infection_Homo sapiens_hsa051320.95870977
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95398139
91Chemokine signaling pathway_Homo sapiens_hsa040620.94900914
92Butanoate metabolism_Homo sapiens_hsa006500.93038931
93Legionellosis_Homo sapiens_hsa051340.92397795
94Pentose phosphate pathway_Homo sapiens_hsa000300.92057746
95Calcium signaling pathway_Homo sapiens_hsa040200.91768326
96Pancreatic cancer_Homo sapiens_hsa052120.91559128
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89558778
98Apoptosis_Homo sapiens_hsa042100.89311925
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.88918332
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87090132
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86809350
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84988090
103Bladder cancer_Homo sapiens_hsa052190.84880241
104Ether lipid metabolism_Homo sapiens_hsa005650.84568768
105Long-term depression_Homo sapiens_hsa047300.84397624
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84148539
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84109437
108Cholinergic synapse_Homo sapiens_hsa047250.83743804
109Gastric acid secretion_Homo sapiens_hsa049710.83712857
110mTOR signaling pathway_Homo sapiens_hsa041500.83162598
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.83064523
112Systemic lupus erythematosus_Homo sapiens_hsa053220.82096263
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81022752
114Rheumatoid arthritis_Homo sapiens_hsa053230.80776021
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79964565
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.79628263
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.79623685
118Oxytocin signaling pathway_Homo sapiens_hsa049210.78809689
119Glucagon signaling pathway_Homo sapiens_hsa049220.77768071
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75680174
121Linoleic acid metabolism_Homo sapiens_hsa005910.75332992
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72933819
123Lysosome_Homo sapiens_hsa041420.72803284
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.71313795
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70874316
126African trypanosomiasis_Homo sapiens_hsa051430.70700394
127Vitamin B6 metabolism_Homo sapiens_hsa007500.69795877
128Phenylalanine metabolism_Homo sapiens_hsa003600.69009823
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.68715828
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68643538
131Prolactin signaling pathway_Homo sapiens_hsa049170.68278767
132cAMP signaling pathway_Homo sapiens_hsa040240.67745073
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.66123715
134Viral carcinogenesis_Homo sapiens_hsa052030.65019802
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64474800
136Platelet activation_Homo sapiens_hsa046110.64406939
137Peroxisome_Homo sapiens_hsa041460.64343607
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63453988
139Pancreatic secretion_Homo sapiens_hsa049720.63197813
140Insulin resistance_Homo sapiens_hsa049310.63110067
141Sphingolipid metabolism_Homo sapiens_hsa006000.62895198
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62862168
143Phagosome_Homo sapiens_hsa041450.62530330
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62410942
145Amoebiasis_Homo sapiens_hsa051460.61224668
146Epstein-Barr virus infection_Homo sapiens_hsa051690.60382483
147Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57483518
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57299601
149Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56907647
150Prion diseases_Homo sapiens_hsa050200.56354828
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55018408
152Sulfur relay system_Homo sapiens_hsa041220.54155331
153Carbon metabolism_Homo sapiens_hsa012000.53749275
154Central carbon metabolism in cancer_Homo sapiens_hsa052300.53707977
155Glycosaminoglycan degradation_Homo sapiens_hsa005310.52018955
156HTLV-I infection_Homo sapiens_hsa051660.51577782
157Histidine metabolism_Homo sapiens_hsa003400.49992084
158Tyrosine metabolism_Homo sapiens_hsa003500.49784361
159Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49036219
160cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48270884
161Notch signaling pathway_Homo sapiens_hsa043300.47941188
162Maturity onset diabetes of the young_Homo sapiens_hsa049500.47772222
163Renal cell carcinoma_Homo sapiens_hsa052110.47691452
164VEGF signaling pathway_Homo sapiens_hsa043700.46125909
165Inositol phosphate metabolism_Homo sapiens_hsa005620.44200487
166Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44064676
167Primary bile acid biosynthesis_Homo sapiens_hsa001200.43842800
168Estrogen signaling pathway_Homo sapiens_hsa049150.43671891
169Endocytosis_Homo sapiens_hsa041440.43411327
170Dorso-ventral axis formation_Homo sapiens_hsa043200.43106502
171Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42843570
172Type II diabetes mellitus_Homo sapiens_hsa049300.41407422
173Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41395039
174Insulin signaling pathway_Homo sapiens_hsa049100.41368483
175GnRH signaling pathway_Homo sapiens_hsa049120.40180628
176HIF-1 signaling pathway_Homo sapiens_hsa040660.39872626
177Fat digestion and absorption_Homo sapiens_hsa049750.39199330
178Steroid biosynthesis_Homo sapiens_hsa001000.39186813
179Chemical carcinogenesis_Homo sapiens_hsa052040.38999901
180Fructose and mannose metabolism_Homo sapiens_hsa000510.38942507
181Endometrial cancer_Homo sapiens_hsa052130.37872087

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »