NUDT19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)7.54306652
2drug transmembrane transport (GO:0006855)7.35463781
3lysine metabolic process (GO:0006553)7.24322434
4lysine catabolic process (GO:0006554)7.24322434
5drug transport (GO:0015893)6.44294247
6cysteine metabolic process (GO:0006534)6.26306808
7aminoglycoside antibiotic metabolic process (GO:0030647)6.16349201
8glyoxylate metabolic process (GO:0046487)5.81816761
9DNA deamination (GO:0045006)5.68915308
10phosphate ion transport (GO:0006817)5.39522713
11L-phenylalanine metabolic process (GO:0006558)5.30729897
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.30729897
13organic cation transport (GO:0015695)5.27425153
14aspartate family amino acid catabolic process (GO:0009068)5.21044951
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.08108689
16L-phenylalanine catabolic process (GO:0006559)5.08108689
17water-soluble vitamin biosynthetic process (GO:0042364)5.04590287
18phosphate ion transmembrane transport (GO:0035435)4.98824381
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.93966708
20drug catabolic process (GO:0042737)4.84405400
21tricarboxylic acid metabolic process (GO:0072350)4.82867764
22short-chain fatty acid metabolic process (GO:0046459)4.81900232
23serine family amino acid metabolic process (GO:0009069)4.75963671
24aromatic amino acid family catabolic process (GO:0009074)4.74969858
25serine family amino acid biosynthetic process (GO:0009070)4.72832165
26proteasome assembly (GO:0043248)4.71760600
27response to mercury ion (GO:0046689)4.69552242
28cellular ketone body metabolic process (GO:0046950)4.65816494
29exogenous drug catabolic process (GO:0042738)4.65812032
30branched-chain amino acid metabolic process (GO:0009081)4.62893841
31ATP synthesis coupled proton transport (GO:0015986)4.56464101
32energy coupled proton transport, down electrochemical gradient (GO:0015985)4.56464101
33valine metabolic process (GO:0006573)4.56126415
34response to pheromone (GO:0019236)4.47631686
35platelet dense granule organization (GO:0060155)4.41839755
36nonribosomal peptide biosynthetic process (GO:0019184)4.39218721
37respiratory chain complex IV assembly (GO:0008535)4.38150961
38tryptophan catabolic process (GO:0006569)4.37977199
39indole-containing compound catabolic process (GO:0042436)4.37977199
40indolalkylamine catabolic process (GO:0046218)4.37977199
412-oxoglutarate metabolic process (GO:0006103)4.37517313
42homocysteine metabolic process (GO:0050667)4.37489708
43branched-chain amino acid catabolic process (GO:0009083)4.35475257
44quaternary ammonium group transport (GO:0015697)4.31649448
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.27409166
46serine family amino acid catabolic process (GO:0009071)4.25271406
47amino-acid betaine metabolic process (GO:0006577)4.16284773
48glutathione biosynthetic process (GO:0006750)4.14939492
49protein complex biogenesis (GO:0070271)4.11399187
50acetyl-CoA metabolic process (GO:0006084)4.08559226
51tryptophan metabolic process (GO:0006568)4.08423203
52cytochrome complex assembly (GO:0017004)4.07911843
53NADH metabolic process (GO:0006734)4.06531351
54ketone body metabolic process (GO:1902224)4.05524020
55tricarboxylic acid cycle (GO:0006099)3.99735952
56oxidative phosphorylation (GO:0006119)3.99463811
57fatty acid beta-oxidation (GO:0006635)3.98239731
58respiratory electron transport chain (GO:0022904)3.93680612
59cellular modified amino acid catabolic process (GO:0042219)3.90542528
60sulfur amino acid catabolic process (GO:0000098)3.88097628
61proline metabolic process (GO:0006560)3.87313937
62succinate metabolic process (GO:0006105)3.84885336
63electron transport chain (GO:0022900)3.83786001
64mitochondrial respiratory chain complex assembly (GO:0033108)3.83308684
65protein K6-linked ubiquitination (GO:0085020)3.81128946
66cellular amino acid catabolic process (GO:0009063)3.78428854
67alpha-amino acid catabolic process (GO:1901606)3.76845369
68aldehyde catabolic process (GO:0046185)3.76832585
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.76734246
70kynurenine metabolic process (GO:0070189)3.76657635
71carnitine metabolic process (GO:0009437)3.68520382
72signal peptide processing (GO:0006465)3.68409112
73aromatic amino acid family metabolic process (GO:0009072)3.68039342
74fatty acid oxidation (GO:0019395)3.66081139
75mitochondrial respiratory chain complex I assembly (GO:0032981)3.62763863
76NADH dehydrogenase complex assembly (GO:0010257)3.62763863
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.62763863
78glutamate metabolic process (GO:0006536)3.62346708
79oxaloacetate metabolic process (GO:0006107)3.61549990
80glycine metabolic process (GO:0006544)3.60714850
81lipid oxidation (GO:0034440)3.58193860
82folic acid metabolic process (GO:0046655)3.57004191
83sulfur amino acid metabolic process (GO:0000096)3.55861573
84fructose metabolic process (GO:0006000)3.50281230
85protein deneddylation (GO:0000338)3.49066196
86fatty acid catabolic process (GO:0009062)3.47706750
87lactate metabolic process (GO:0006089)3.44287203
88carboxylic acid catabolic process (GO:0046395)3.43610856
89organic acid catabolic process (GO:0016054)3.43610856
90dicarboxylic acid metabolic process (GO:0043648)3.43453384
91cullin deneddylation (GO:0010388)3.39450057
92mannosylation (GO:0097502)3.36285716
93modified amino acid transport (GO:0072337)3.32236556
94renal absorption (GO:0070293)3.31020406
95preassembly of GPI anchor in ER membrane (GO:0016254)3.30661648
96toxin transport (GO:1901998)3.30014557
97glutathione metabolic process (GO:0006749)3.28470665
98monocarboxylic acid catabolic process (GO:0072329)3.28386231
99pseudouridine synthesis (GO:0001522)3.27177831
100cytidine deamination (GO:0009972)3.24873827
101cytidine metabolic process (GO:0046087)3.24873827
102cytidine catabolic process (GO:0006216)3.24873827
103replication fork processing (GO:0031297)3.24859343
104excretion (GO:0007588)3.23881059
105inositol phosphate catabolic process (GO:0071545)3.23760525
106aspartate family amino acid metabolic process (GO:0009066)3.23006309
107amino-acid betaine transport (GO:0015838)3.22534694
108carnitine transport (GO:0015879)3.22534694
109drug metabolic process (GO:0017144)3.22144432
110L-fucose catabolic process (GO:0042355)3.21498729
111fucose catabolic process (GO:0019317)3.21498729
112L-fucose metabolic process (GO:0042354)3.21498729
113regulation of hexokinase activity (GO:1903299)3.21237471
114regulation of glucokinase activity (GO:0033131)3.21237471
115metanephric tubule development (GO:0072170)3.18668092
116metanephric nephron tubule development (GO:0072234)3.18668092
117peptide biosynthetic process (GO:0043043)3.16844154
118maturation of 5.8S rRNA (GO:0000460)3.16616532
119regulation of cellular amino acid metabolic process (GO:0006521)3.14037907
120DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.12622904
121ethanol oxidation (GO:0006069)3.10739875
122glutathione derivative biosynthetic process (GO:1901687)3.10105394
123glutathione derivative metabolic process (GO:1901685)3.10105394
124nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09641840
125vitamin D metabolic process (GO:0042359)3.09272393
126benzene-containing compound metabolic process (GO:0042537)3.08565358
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08023886
128bile acid biosynthetic process (GO:0006699)3.07703552
129cellular biogenic amine catabolic process (GO:0042402)3.06519318
130amine catabolic process (GO:0009310)3.06519318
131inositol phosphate dephosphorylation (GO:0046855)3.05873963
132phosphorylated carbohydrate dephosphorylation (GO:0046838)3.05873963
133signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.04536623
134signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.04536623
135signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.04536623
136small molecule catabolic process (GO:0044282)3.03563809
137sulfur amino acid biosynthetic process (GO:0000097)3.03318579
138signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.02522838
139intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.02522838
140DNA double-strand break processing (GO:0000729)3.01912068
141glycoside metabolic process (GO:0016137)3.01774125
142indolalkylamine metabolic process (GO:0006586)3.01197459
143heme biosynthetic process (GO:0006783)3.00753317
144L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.96121084
145polyol catabolic process (GO:0046174)2.91139174
146establishment of protein localization to mitochondrial membrane (GO:0090151)2.90963349
147RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.88486525
148synapsis (GO:0007129)2.88029438
149S-adenosylmethionine metabolic process (GO:0046500)2.87489076
150signal transduction involved in DNA integrity checkpoint (GO:0072401)2.84792175
151signal transduction involved in DNA damage checkpoint (GO:0072422)2.84792175
152peptidyl-histidine modification (GO:0018202)2.82790055
153signal transduction involved in cell cycle checkpoint (GO:0072395)2.82679078
154dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.82348610
155rRNA modification (GO:0000154)2.81065758
156C-terminal protein lipidation (GO:0006501)2.80850926
157positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.80803013
158detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79232010
159somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.77514740
160isotype switching (GO:0045190)2.77514740
161somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.77514740
162keratinocyte development (GO:0003334)2.75823356
163behavioral response to nicotine (GO:0035095)2.71894587
164regulation of B cell apoptotic process (GO:0002902)2.71839730
165protein K11-linked deubiquitination (GO:0035871)2.70917010
166anterograde synaptic vesicle transport (GO:0048490)2.69725227
167negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67491653
168protein neddylation (GO:0045116)2.66915490
169rRNA methylation (GO:0031167)2.64483353
170regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.64458785
171regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.64269439
172C-terminal protein amino acid modification (GO:0018410)2.61288923
173piRNA metabolic process (GO:0034587)2.59874086
174double-strand break repair via homologous recombination (GO:0000724)2.59448934
175recombinational repair (GO:0000725)2.59408682
176L-methionine salvage (GO:0071267)2.59290741
177L-methionine biosynthetic process (GO:0071265)2.59290741
178amino acid salvage (GO:0043102)2.59290741
179pyrimidine ribonucleoside catabolic process (GO:0046133)2.58514738
180negative regulation of neurological system process (GO:0031645)2.58416873
181rRNA catabolic process (GO:0016075)2.56960202
182positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.56889165
183DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.53369595
184negative regulation of DNA-dependent DNA replication (GO:2000104)2.52910722
185positive regulation of ligase activity (GO:0051351)2.50264141
186GPI anchor metabolic process (GO:0006505)2.48719177
187transcription elongation from RNA polymerase III promoter (GO:0006385)2.46502646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.85596659
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.65309516
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.57059442
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.98987622
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.58385866
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.55246293
7* MYC_18555785_ChIP-Seq_MESCs_Mouse3.48447440
8ZNF274_21170338_ChIP-Seq_K562_Hela3.16476746
9VDR_22108803_ChIP-Seq_LS180_Human3.10305013
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02714462
11* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.99739980
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.85043357
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77604210
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67704338
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65457817
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63961335
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.61425123
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.56549288
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.55751878
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.54069927
21* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.42762862
22LXR_22158963_ChIP-Seq_LIVER_Mouse2.41563733
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.39348330
24ELK1_19687146_ChIP-ChIP_HELA_Human2.36671791
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35946725
26AR_21909140_ChIP-Seq_LNCAP_Human2.33158770
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27715570
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.25943121
29FLI1_27457419_Chip-Seq_LIVER_Mouse2.17234667
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14902694
31EWS_26573619_Chip-Seq_HEK293_Human2.11232032
32ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10852123
33NOTCH1_21737748_ChIP-Seq_TLL_Human2.10457878
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09779804
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.08375007
36E2F7_22180533_ChIP-Seq_HELA_Human2.07802667
37* SRF_21415370_ChIP-Seq_HL-1_Mouse2.05582538
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02224098
39* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99873764
40FUS_26573619_Chip-Seq_HEK293_Human1.91437011
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.86791282
42IGF1R_20145208_ChIP-Seq_DFB_Human1.86097926
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85160493
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.83756267
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82800859
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.78627482
47DCP1A_22483619_ChIP-Seq_HELA_Human1.78037990
48MYC_18940864_ChIP-ChIP_HL60_Human1.76632980
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74985148
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73781541
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70527499
52GBX2_23144817_ChIP-Seq_PC3_Human1.67720093
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66847956
54XRN2_22483619_ChIP-Seq_HELA_Human1.66832097
55P300_19829295_ChIP-Seq_ESCs_Human1.66330909
56VDR_23849224_ChIP-Seq_CD4+_Human1.64316011
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61159810
58* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60091470
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.57565171
60GABP_19822575_ChIP-Seq_HepG2_Human1.56179785
61ER_23166858_ChIP-Seq_MCF-7_Human1.56121918
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52367511
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50388915
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50015967
65TP53_22573176_ChIP-Seq_HFKS_Human1.48412120
66FOXP3_21729870_ChIP-Seq_TREG_Human1.47780038
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.47762925
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47565431
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46553711
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.46242695
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45706903
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43891511
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43271747
74* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42765797
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42525240
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41885181
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40729038
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38571461
79CBP_20019798_ChIP-Seq_JUKART_Human1.38571461
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38299063
81NANOG_19829295_ChIP-Seq_ESCs_Human1.38231952
82SOX2_19829295_ChIP-Seq_ESCs_Human1.38231952
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.38129466
84CTCF_18555785_ChIP-Seq_MESCs_Mouse1.37777193
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36950928
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.36950928
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36685347
88IRF8_22096565_ChIP-ChIP_GC-B_Human1.36305009
89* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35761421
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35301894
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35166222
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32876907
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31861975
94CRX_20693478_ChIP-Seq_RETINA_Mouse1.29969370
95TAF15_26573619_Chip-Seq_HEK293_Human1.26978894
96AR_20517297_ChIP-Seq_VCAP_Human1.26706290
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25188798
98TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.21893147
99BCAT_22108803_ChIP-Seq_LS180_Human1.21043106
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20961928
101E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20433559
102FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18410204
103* NCOR_22424771_ChIP-Seq_293T_Human1.17324201
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17009155
105CDX2_22108803_ChIP-Seq_LS180_Human1.15842762
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15598549
107* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15200117
108GATA1_22025678_ChIP-Seq_K562_Human1.14508661
109HOXB7_26014856_ChIP-Seq_BT474_Human1.13547473
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13011559
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11416489
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10896026
113TCF4_22108803_ChIP-Seq_LS180_Human1.10623344
114STAT3_18555785_Chip-Seq_ESCs_Mouse1.08763103
115AR_25329375_ChIP-Seq_VCAP_Human1.06073368
116SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06023005
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05836374
118GATA3_26560356_Chip-Seq_TH2_Human1.05606817
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05370423
120SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05230592
121AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05017209
122P53_22387025_ChIP-Seq_ESCs_Mouse1.04924926
123TTF2_22483619_ChIP-Seq_HELA_Human1.04629889
124PHF8_20622853_ChIP-Seq_HELA_Human1.04523798
125PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03882312
126HTT_18923047_ChIP-ChIP_STHdh_Human1.02897641
127IRF1_19129219_ChIP-ChIP_H3396_Human1.02643337
128NANOG_18555785_Chip-Seq_ESCs_Mouse1.02565410
129MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02547463
130GATA3_21878914_ChIP-Seq_MCF-7_Human1.01425449
131SMAD4_21799915_ChIP-Seq_A2780_Human1.01363893
132CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01008513
133* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00921811
134PIAS1_25552417_ChIP-Seq_VCAP_Human1.00652379
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00099522
136STAT3_23295773_ChIP-Seq_U87_Human0.99756145
137RBPJ_21746931_ChIP-Seq_IB4_Human0.99739952
138ZNF263_19887448_ChIP-Seq_K562_Human0.99730830
139SMAD_19615063_ChIP-ChIP_OVARY_Human0.98865992
140EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98718961
141* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98439319
142OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97799194
143KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97736518
144TCF4_23295773_ChIP-Seq_U87_Human0.95492712
145P300_18555785_Chip-Seq_ESCs_Mouse0.95474452
146SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95389177
147TET1_21451524_ChIP-Seq_MESCs_Mouse0.95001631
148GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94352751
149SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92431640
150CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91510181
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.90888605
152RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90170489
153NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89300011
154POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88915744
155NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87643860
156NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87436997
157SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87003079
158POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.86342516
159* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85883429
160GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85816419
161TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84332997
162OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84208523
163POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83887099
164KDM5A_27292631_Chip-Seq_BREAST_Human0.83038123
165* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82511572
166SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82371029
167ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81528402
168LXR_22292898_ChIP-Seq_THP-1_Human0.79217975
169* CTCF_26484167_Chip-Seq_Bcells_Mouse0.78959819
170STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78095349
171PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77749776
172FOXP1_21924763_ChIP-Seq_HESCs_Human0.77645656
173GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76209317
174* HNF4A_19822575_ChIP-Seq_HepG2_Human0.74974125
175SOX2_22085726_ChIP-Seq_NPCs_Mouse0.72413120
176KLF4_18555785_ChIP-Seq_MESCs_Mouse0.72046344
177PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71505198

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.38464259
2MP0002139_abnormal_hepatobiliary_system5.78315227
3MP0004043_abnormal_pH_regulation4.79860916
4MP0005332_abnormal_amino_acid4.60300880
5MP0000372_irregular_coat_pigmentation4.03535181
6MP0003195_calcinosis3.97926937
7MP0003806_abnormal_nucleotide_metabolis3.81920457
8MP0008875_abnormal_xenobiotic_pharmacok3.57849984
9MP0005085_abnormal_gallbladder_physiolo3.55123585
10MP0004019_abnormal_vitamin_homeostasis3.46083040
11MP0005365_abnormal_bile_salt3.42990185
12MP0009643_abnormal_urine_homeostasis3.11755742
13MP0002102_abnormal_ear_morphology3.06036039
14MP0002138_abnormal_hepatobiliary_system3.02439815
15MP0005636_abnormal_mineral_homeostasis2.81065597
16MP0006036_abnormal_mitochondrial_physio2.81000492
17MP0003186_abnormal_redox_activity2.59229368
18MP0005174_abnormal_tail_pigmentation2.48163471
19MP0001765_abnormal_ion_homeostasis2.44442542
20MP0003252_abnormal_bile_duct2.40891785
21MP0004147_increased_porphyrin_level2.38294504
22MP0002163_abnormal_gland_morphology2.29438259
23MP0001756_abnormal_urination2.27748741
24MP0005645_abnormal_hypothalamus_physiol2.23785722
25MP0003786_premature_aging2.21269882
26MP0005646_abnormal_pituitary_gland2.10474702
27MP0000015_abnormal_ear_pigmentation2.10381817
28MP0005379_endocrine/exocrine_gland_phen2.09013393
29MP0005075_abnormal_melanosome_morpholog2.06173018
30MP0005584_abnormal_enzyme/coenzyme_acti2.03343673
31MP0006035_abnormal_mitochondrial_morpho1.99681118
32MP0002136_abnormal_kidney_physiology1.96098815
33MP0002938_white_spotting1.95821100
34MP0008877_abnormal_DNA_methylation1.86700557
35MP0000569_abnormal_digit_pigmentation1.84462082
36MP0001764_abnormal_homeostasis1.80971114
37MP0003656_abnormal_erythrocyte_physiolo1.80929080
38MP0008058_abnormal_DNA_repair1.79641928
39MP0005319_abnormal_enzyme/_coenzyme1.78964003
40MP0005377_hearing/vestibular/ear_phenot1.72885887
41MP0003878_abnormal_ear_physiology1.72885887
42MP0006072_abnormal_retinal_apoptosis1.72505663
43MP0000516_abnormal_urinary_system1.70769449
44MP0005367_renal/urinary_system_phenotyp1.70769449
45MP0005551_abnormal_eye_electrophysiolog1.69641116
46MP0005084_abnormal_gallbladder_morpholo1.67644153
47MP0003283_abnormal_digestive_organ1.66753161
48MP0001666_abnormal_nutrient_absorption1.66617741
49MP0005083_abnormal_biliary_tract1.64326463
50MP0009780_abnormal_chondrocyte_physiolo1.64288423
51MP0002160_abnormal_reproductive_system1.63796199
52MP0002166_altered_tumor_susceptibility1.58440731
53MP0003646_muscle_fatigue1.57953848
54MP0005389_reproductive_system_phenotype1.56652230
55MP0010329_abnormal_lipoprotein_level1.54703141
56MP0010234_abnormal_vibrissa_follicle1.53108934
57MP0000427_abnormal_hair_cycle1.52804206
58MP0005253_abnormal_eye_physiology1.45098364
59MP0008775_abnormal_heart_ventricle1.43041047
60MP0003950_abnormal_plasma_membrane1.39628244
61MP0004145_abnormal_muscle_electrophysio1.37269336
62MP0005171_absent_coat_pigmentation1.37221487
63MP0002095_abnormal_skin_pigmentation1.37205661
64MP0002693_abnormal_pancreas_physiology1.36222753
65MP0003136_yellow_coat_color1.35107961
66MP0005058_abnormal_lysosome_morphology1.32706772
67MP0002638_abnormal_pupillary_reflex1.32500879
68MP0009046_muscle_twitch1.31027692
69MP0004381_abnormal_hair_follicle1.28293039
70MP0002118_abnormal_lipid_homeostasis1.23447053
71MP0002234_abnormal_pharynx_morphology1.20683053
72MP0002006_tumorigenesis1.19746690
73MP0001986_abnormal_taste_sensitivity1.16251981
74MP0001944_abnormal_pancreas_morphology1.15583615
75MP0002736_abnormal_nociception_after1.14946555
76MP0002277_abnormal_respiratory_mucosa1.14640017
77MP0005451_abnormal_body_composition1.14491343
78MP0000609_abnormal_liver_physiology1.14307617
79MP0001968_abnormal_touch/_nociception1.13968070
80MP0009840_abnormal_foam_cell1.12571155
81MP0005535_abnormal_body_temperature1.10963200
82MP0009697_abnormal_copulation1.09302840
83MP0001919_abnormal_reproductive_system1.07515898
84MP0010094_abnormal_chromosome_stability1.06134819
85MP0003191_abnormal_cellular_cholesterol1.04869511
86MP0000230_abnormal_systemic_arterial1.02388444
87MP0005410_abnormal_fertilization1.01432201
88MP0000747_muscle_weakness0.99855406
89MP0008995_early_reproductive_senescence0.99519249
90MP0002876_abnormal_thyroid_physiology0.98708373
91MP0000013_abnormal_adipose_tissue0.98052881
92MP0000371_diluted_coat_color0.97233751
93MP0004134_abnormal_chest_morphology0.91248127
94MP0008872_abnormal_physiological_respon0.90859211
95MP0000613_abnormal_salivary_gland0.90491068
96MP0004215_abnormal_myocardial_fiber0.89578141
97MP0009642_abnormal_blood_homeostasis0.89156529
98MP0000598_abnormal_liver_morphology0.87374362
99MP0005266_abnormal_metabolism0.87272656
100MP0001958_emphysema0.86744918
101MP0010678_abnormal_skin_adnexa0.86455226
102MP0000358_abnormal_cell_content/0.86383520
103MP0004957_abnormal_blastocyst_morpholog0.86127056
104MP0008469_abnormal_protein_level0.86119578
105MP0001324_abnormal_eye_pigmentation0.85482596
106MP0003221_abnormal_cardiomyocyte_apopto0.84732039
107MP0003638_abnormal_response/metabolism_0.84287514
108MP0005670_abnormal_white_adipose0.83318335
109MP0005220_abnormal_exocrine_pancreas0.83261360
110MP0006054_spinal_hemorrhage0.82732453
111MP0000538_abnormal_urinary_bladder0.81761899
112MP0000631_abnormal_neuroendocrine_gland0.81410759
113MP0009745_abnormal_behavioral_response0.78923963
114MP0008961_abnormal_basal_metabolism0.78714940
115MP0001984_abnormal_olfaction0.78369748
116MP0002751_abnormal_autonomic_nervous0.78231391
117MP0001661_extended_life_span0.77685230
118MP0001929_abnormal_gametogenesis0.77293249
119MP0002928_abnormal_bile_duct0.77217861
120MP0002909_abnormal_adrenal_gland0.77063455
121MP0003137_abnormal_impulse_conducting0.76166406
122MP0005376_homeostasis/metabolism_phenot0.75047222
123MP0002090_abnormal_vision0.74902461
124MP0003787_abnormal_imprinting0.73564956
125MP0009764_decreased_sensitivity_to0.73397675
126MP0002135_abnormal_kidney_morphology0.71505157
127MP0004885_abnormal_endolymph0.71024651
128MP0001119_abnormal_female_reproductive0.70634536
129MP0001529_abnormal_vocalization0.68574908
130MP0004233_abnormal_muscle_weight0.68354602
131MP0005671_abnormal_response_to0.68212272
132MP0005330_cardiomyopathy0.67489486
133MP0002078_abnormal_glucose_homeostasis0.67200978
134MP0003045_fibrosis0.66964711
135MP0003329_amyloid_beta_deposits0.65272914
136MP0000749_muscle_degeneration0.61922869
137MP0003868_abnormal_feces_composition0.61132882
138MP0002089_abnormal_postnatal_growth/wei0.59829301
139MP0001663_abnormal_digestive_system0.59801554
140MP0002396_abnormal_hematopoietic_system0.58775996
141MP0002269_muscular_atrophy0.55216150
142MP0000751_myopathy0.54429457
143MP0003693_abnormal_embryo_hatching0.54374824
144MP0009379_abnormal_foot_pigmentation0.53873032
145MP0004142_abnormal_muscle_tone0.53705101
146MP0002837_dystrophic_cardiac_calcinosis0.51173606
147MP0003959_abnormal_lean_body0.50565250
148MP0009765_abnormal_xenobiotic_induced0.49622296
149MP0005165_increased_susceptibility_to0.49562325
150MP0005666_abnormal_adipose_tissue0.48974088
151MP0003172_abnormal_lysosome_physiology0.48430363
152MP0003879_abnormal_hair_cell0.47861589
153MP0003953_abnormal_hormone_level0.46074280
154MP0008873_increased_physiological_sensi0.45906934
155MP0005408_hypopigmentation0.45868576
156MP0000490_abnormal_crypts_of0.45389882
157MP0001485_abnormal_pinna_reflex0.44653807
158MP0003718_maternal_effect0.42935474
159MP0009763_increased_sensitivity_to0.42208018
160MP0005395_other_phenotype0.41225430
161MP0002822_catalepsy0.41136036
162MP0001905_abnormal_dopamine_level0.40916084
163MP0004036_abnormal_muscle_relaxation0.40342215
164MP0005381_digestive/alimentary_phenotyp0.37338223
165MP0000604_amyloidosis0.36674735
166MP0008874_decreased_physiological_sensi0.35889393

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)5.92177399
2Increased circulating renin level (HP:0000848)5.20416412
3Hypomagnesemia (HP:0002917)4.96661101
4Metabolic alkalosis (HP:0200114)4.92606404
5Hypokalemic alkalosis (HP:0001949)4.91283182
6Proximal tubulopathy (HP:0000114)4.54538203
7Hyperglycinuria (HP:0003108)4.49178866
8Hyperactive renin-angiotensin system (HP:0000841)4.48290071
9Abnormality of magnesium homeostasis (HP:0004921)4.40917423
10Polyuria (HP:0000103)4.32951479
11Increased purine levels (HP:0004368)4.19936596
12Hyperuricemia (HP:0002149)4.19936596
13Abnormal urine output (HP:0012590)4.14100571
14Generalized aminoaciduria (HP:0002909)4.00524345
15Abnormality of glycine metabolism (HP:0010895)3.97035941
16Abnormality of serine family amino acid metabolism (HP:0010894)3.97035941
17Ketoacidosis (HP:0001993)3.97015219
18Abnormality of purine metabolism (HP:0004352)3.89041541
19Abnormality of chloride homeostasis (HP:0011422)3.88671163
20Abnormality of renal excretion (HP:0011036)3.87022089
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.86865670
22Ketosis (HP:0001946)3.85689010
23Abnormality of aromatic amino acid family metabolism (HP:0004338)3.84033165
24Glycosuria (HP:0003076)3.83151296
25Abnormality of urine glucose concentration (HP:0011016)3.83151296
26Alkalosis (HP:0001948)3.72735551
27Acute encephalopathy (HP:0006846)3.72268501
28Abnormality of fatty-acid metabolism (HP:0004359)3.54276626
29Hyperammonemia (HP:0001987)3.44914685
30Hyperphosphaturia (HP:0003109)3.43938269
31Hepatic necrosis (HP:0002605)3.40544696
32Abnormal drinking behavior (HP:0030082)3.36213934
33Polydipsia (HP:0001959)3.36213934
34Pancreatic cysts (HP:0001737)3.32024476
35Hyperglycinemia (HP:0002154)3.29196040
36Cerebral edema (HP:0002181)3.28993345
37Dicarboxylic aciduria (HP:0003215)3.28471355
38Abnormality of dicarboxylic acid metabolism (HP:0010995)3.28471355
39Abnormal mitochondria in muscle tissue (HP:0008316)3.26824058
40Delayed CNS myelination (HP:0002188)3.26081078
41Congenital stationary night blindness (HP:0007642)3.24612145
42Renal salt wasting (HP:0000127)3.23649292
43Abnormality of nucleobase metabolism (HP:0010932)3.23399036
44Abnormality of aspartate family amino acid metabolism (HP:0010899)3.22885736
45Hepatocellular necrosis (HP:0001404)3.19560716
46Acute necrotizing encephalopathy (HP:0006965)3.18716381
47Tetany (HP:0001281)3.18559624
48Methylmalonic acidemia (HP:0002912)3.16710987
49Cutaneous melanoma (HP:0012056)3.16361293
50Hyperaldosteronism (HP:0000859)3.14349166
51Lethargy (HP:0001254)3.12414854
52Abnormality of renin-angiotensin system (HP:0000847)3.10662247
53Metabolic acidosis (HP:0001942)3.03075784
54Pancreatic fibrosis (HP:0100732)2.99001697
55Mitochondrial inheritance (HP:0001427)2.96206959
56Abnormality of the renal cortex (HP:0011035)2.94093994
57Tongue fasciculations (HP:0001308)2.93690758
58Abnormal urine phosphate concentration (HP:0012599)2.91412839
59Neoplasm of the adrenal cortex (HP:0100641)2.89110057
60Increased CSF lactate (HP:0002490)2.89005727
61Conjunctival hamartoma (HP:0100780)2.88225546
62Vomiting (HP:0002013)2.88162879
63True hermaphroditism (HP:0010459)2.86693661
64Hypothermia (HP:0002045)2.84411325
65Abnormality of glycolysis (HP:0004366)2.81347200
66Increased serum pyruvate (HP:0003542)2.81347200
67Renal tubular acidosis (HP:0001947)2.79691591
68Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78157740
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78157740
70Renal cortical cysts (HP:0000803)2.75247066
71Abnormality of midbrain morphology (HP:0002418)2.73217560
72Molar tooth sign on MRI (HP:0002419)2.73217560
73Lactic acidosis (HP:0003128)2.72191183
74Hamartoma of the eye (HP:0010568)2.70488840
75Large for gestational age (HP:0001520)2.70161387
76Hypoplasia of the fovea (HP:0007750)2.65259588
77Aplasia/Hypoplasia of the fovea (HP:0008060)2.65259588
78Increased muscle lipid content (HP:0009058)2.62835141
79Increased intramyocellular lipid droplets (HP:0012240)2.59932387
80Methylmalonic aciduria (HP:0012120)2.59212547
81Neoplasm of the adrenal gland (HP:0100631)2.58734664
82Nausea (HP:0002018)2.53893041
83Hypercalciuria (HP:0002150)2.53555395
84Progressive macrocephaly (HP:0004481)2.53154016
85Abnormality of serum amino acid levels (HP:0003112)2.50558372
86Abnormality of sulfur amino acid metabolism (HP:0004339)2.49582760
87Abnormality of renal resorption (HP:0011038)2.49144690
88Congenital, generalized hypertrichosis (HP:0004540)2.48893869
89Albinism (HP:0001022)2.45275687
90Furrowed tongue (HP:0000221)2.43982805
91Increased serum lactate (HP:0002151)2.38401033
92Renal tubular dysfunction (HP:0000124)2.37052695
93Hypokalemia (HP:0002900)2.35876691
94Meningioma (HP:0002858)2.34930727
95Hypoglycemic coma (HP:0001325)2.33969667
96Nephronophthisis (HP:0000090)2.33426326
97Lipid accumulation in hepatocytes (HP:0006561)2.33078413
98Muscle fibrillation (HP:0010546)2.32524710
99Abnormality of vitamin B metabolism (HP:0004340)2.31878450
100Thyroiditis (HP:0100646)2.31339793
1013-Methylglutaconic aciduria (HP:0003535)2.31013447
102Intrahepatic cholestasis (HP:0001406)2.30812450
103Abnormality of monocarboxylic acid metabolism (HP:0010996)2.25123903
104Nephrolithiasis (HP:0000787)2.24724794
105Late onset (HP:0003584)2.23201477
106Abnormality of the heme biosynthetic pathway (HP:0010472)2.23176632
107Hyperbilirubinemia (HP:0002904)2.21024945
108Abnormality of the fovea (HP:0000493)2.19994947
109Attenuation of retinal blood vessels (HP:0007843)2.17756838
110Medial flaring of the eyebrow (HP:0010747)2.17041800
111Abnormal rod and cone electroretinograms (HP:0008323)2.13996518
112Xanthomatosis (HP:0000991)2.13881636
113CNS demyelination (HP:0007305)2.12612624
114Respiratory failure (HP:0002878)2.12552531
115Hyperglycemia (HP:0003074)2.11819128
116Pendular nystagmus (HP:0012043)2.10896422
117Abnormality of methionine metabolism (HP:0010901)2.10839204
118Congenital sensorineural hearing impairment (HP:0008527)2.10683113
119Intestinal atresia (HP:0011100)2.09155897
120Optic disc pallor (HP:0000543)2.08023796
121Type I transferrin isoform profile (HP:0003642)2.07868479
122Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.07125087
123Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07001377
124Hyperinsulinemic hypoglycemia (HP:0000825)2.05788364
125Abnormality of the renal medulla (HP:0100957)2.05089602
126Increased hepatocellular lipid droplets (HP:0006565)2.03991281
127Reticulocytopenia (HP:0001896)2.03727254
128Delayed epiphyseal ossification (HP:0002663)2.02119459
129Malnutrition (HP:0004395)1.99875694
130Confusion (HP:0001289)1.98432968
131Irritability (HP:0000737)1.98328134
132Abnormal number of erythroid precursors (HP:0012131)1.97424093
133Abnormality of the vitamin B12 metabolism (HP:0004341)1.95835069
134Nephrocalcinosis (HP:0000121)1.94822321
135Abnormality of cells of the erythroid lineage (HP:0012130)1.93903811
136Renal Fanconi syndrome (HP:0001994)1.93481183
137Absent thumb (HP:0009777)1.93455168
138Gaze-evoked nystagmus (HP:0000640)1.93284662
139Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92131363
140Abnormality of pyrimidine metabolism (HP:0004353)1.92114024
141Aplasia/hypoplasia of the uterus (HP:0008684)1.92092818
142Progressive inability to walk (HP:0002505)1.91441789
143Vascular calcification (HP:0004934)1.90087005
144Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89416276
145Abnormality of alanine metabolism (HP:0010916)1.89416276
146Hyperalaninemia (HP:0003348)1.89416276
147Hydroxyprolinuria (HP:0003080)1.89088012
148Abnormal protein glycosylation (HP:0012346)1.88406986
149Abnormal glycosylation (HP:0012345)1.88406986
150Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88406986
151Abnormal protein N-linked glycosylation (HP:0012347)1.88406986
152Abolished electroretinogram (ERG) (HP:0000550)1.86694664
153Adrenal hypoplasia (HP:0000835)1.83163112
154Sclerocornea (HP:0000647)1.81892083
155Decreased central vision (HP:0007663)1.80394449
156Tubular atrophy (HP:0000092)1.77552181
157Type II lissencephaly (HP:0007260)1.76711338
158Aplasia/Hypoplasia of the macula (HP:0008059)1.76527053
159Male pseudohermaphroditism (HP:0000037)1.74506833
160Abnormal biliary tract physiology (HP:0012439)1.74241016
161Bile duct proliferation (HP:0001408)1.74241016
162Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.74199340
163Aplasia/Hypoplasia of the uvula (HP:0010293)1.72360639
164Stomatitis (HP:0010280)1.72236888
165Pancytopenia (HP:0001876)1.70796611
166Melanoma (HP:0002861)1.69572459
167Hypoproteinemia (HP:0003075)1.68974741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.50511600
2WNK36.22102975
3WNK46.01587440
4BCKDK5.71594770
5OXSR15.58859633
6NME23.62708699
7NEK13.09764694
8NUAK12.84727126
9STK392.77432795
10BMPR1B2.71758518
11EIF2AK12.57008357
12STK162.49464366
13GRK12.19277349
14TRIM282.13826007
15ADRBK22.10941125
16PDK32.01959343
17PDK42.01959343
18VRK22.01618858
19WEE11.85775240
20MKNK21.84884007
21SCYL21.79715710
22MAP4K21.72235465
23BUB11.69974340
24FGFR21.66284221
25ZAK1.61036769
26ACVR1B1.60765234
27MAP3K111.56026157
28ERBB31.52693698
29PLK21.48390794
30PLK31.47188936
31MAPKAPK31.46907235
32NME11.45894468
33INSRR1.41439524
34EIF2AK31.34102630
35PAK31.33786545
36TESK21.32056994
37GRK61.30221826
38PINK11.29803468
39FER1.29710477
40TAOK31.18455006
41STK38L1.18319573
42CSNK1G11.15804390
43CSNK1G31.13099475
44LRRK21.12590423
45ABL21.04301286
46FLT31.03257878
47MKNK11.01084810
48CSNK1G20.95602063
49PDK20.95068415
50STK240.94811265
51KDR0.94154958
52MYLK0.92976180
53BCR0.89997770
54MAP2K30.89806865
55TXK0.89714267
56MAP2K60.89494208
57TAF10.88014385
58TLK10.87436703
59VRK10.87239511
60EIF2AK20.87040704
61CDK190.86433039
62CSNK1A1L0.85354357
63IKBKB0.84802158
64TRPM70.83446097
65MAPKAPK50.82283722
66MAPK130.80638186
67PIM20.79296807
68MAPK110.77683173
69STK30.77644694
70ADRBK10.76643491
71MST40.75716662
72MAP3K120.75336887
73MST1R0.73567649
74SIK30.72254074
75ARAF0.71980597
76BRSK10.71862811
77PIK3CA0.70899300
78CASK0.70613027
79PRKCE0.69112878
80SGK4940.69025250
81SGK2230.69025250
82MUSK0.67164217
83DAPK10.66923048
84BRSK20.65456300
85BMPR20.64445152
86AURKA0.64286594
87MAP2K40.62425000
88PTK2B0.60565179
89MINK10.57857607
90TEC0.57777449
91AKT30.57652089
92DAPK20.56586941
93CCNB10.56058049
94TGFBR10.55998683
95OBSCN0.51500364
96PKN20.51105279
97GRK50.49589401
98CDC70.48732500
99PRKCQ0.48657408
100MAP4K10.46007203
101PLK40.45645783
102EPHA40.42363925
103PBK0.40863865
104TESK10.39986291
105STK100.39209393
106RPS6KA50.37821428
107CSNK1A10.36598984
108CSNK2A20.36319555
109LMTK20.36115653
110MAP2K10.35037012
111LIMK10.34843233
112PRKAA20.34385677
113KIT0.34175435
114CDK80.34154683
115MARK30.33991433
116MAP3K70.33764584
117BRAF0.33180640
118DYRK30.32765440
119ABL10.32597021
120ILK0.31864717
121DAPK30.31618225
122MAP3K80.31007746
123MAPK40.30916637
124ATM0.30859120
125TNIK0.30668276
126PAK40.30625045
127PRKCD0.30412752
128WNK10.30205196
129CSNK1D0.30044702
130CSNK2A10.29871778
131MAPK120.28643225
132AURKB0.28273265
133RAF10.28131021
134TTK0.27812935
135CAMK2G0.27575104
136IGF1R0.26582112
137TNK20.26070859
138ITK0.25610996
139AKT20.25332433
140ZAP700.25213712
141PIK3CG0.25020446
142ATR0.24980195
143TSSK60.24203529
144PRKCG0.24024921
145TYK20.23185017
146PRKACG0.22998387
147CDK40.22063262
148FGFR40.21167330
149PRKG20.21144130
150PHKG20.21078273
151PHKG10.21078273
152PRKCI0.20522529
153PRKACA0.18696200
154CAMKK20.18571092
155MAP2K20.18197682
156PRKCA0.16991619
157PLK10.16832686
158PRKAA10.16448790
159GSK3A0.16257013
160NEK90.15875256
161ERN10.15872116
162PRKCZ0.15853186
163STK380.15602294

Predicted pathways (KEGG)

RankGene SetZ-score
1Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.14600001
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.05216087
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.04363830
4Butanoate metabolism_Homo sapiens_hsa006503.02597333
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.93234566
6Propanoate metabolism_Homo sapiens_hsa006402.92846089
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.90347967
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.77615610
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.62183754
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.56521902
11Pyruvate metabolism_Homo sapiens_hsa006202.39246711
12Fatty acid degradation_Homo sapiens_hsa000712.36827670
13Oxidative phosphorylation_Homo sapiens_hsa001902.29531882
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26794013
15* Peroxisome_Homo sapiens_hsa041462.22334030
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.12829630
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.11690989
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.09491070
19Carbon metabolism_Homo sapiens_hsa012002.04187293
20Parkinsons disease_Homo sapiens_hsa050122.03076595
21Tryptophan metabolism_Homo sapiens_hsa003801.97921853
22Homologous recombination_Homo sapiens_hsa034401.83880270
23Folate biosynthesis_Homo sapiens_hsa007901.83239876
24beta-Alanine metabolism_Homo sapiens_hsa004101.81440122
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79566729
26Non-homologous end-joining_Homo sapiens_hsa034501.77376160
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.75928324
28Sulfur metabolism_Homo sapiens_hsa009201.74501724
29Basal transcription factors_Homo sapiens_hsa030221.71718448
30Biosynthesis of amino acids_Homo sapiens_hsa012301.66634202
31Fatty acid metabolism_Homo sapiens_hsa012121.66499632
32Fanconi anemia pathway_Homo sapiens_hsa034601.66358004
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.61119082
34Phototransduction_Homo sapiens_hsa047441.56717928
35RNA degradation_Homo sapiens_hsa030181.56643776
36Glutathione metabolism_Homo sapiens_hsa004801.55692546
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50580215
38Linoleic acid metabolism_Homo sapiens_hsa005911.48846304
39Arginine biosynthesis_Homo sapiens_hsa002201.48281158
40Sulfur relay system_Homo sapiens_hsa041221.40078065
41Ribosome_Homo sapiens_hsa030101.38871063
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38398574
43Selenocompound metabolism_Homo sapiens_hsa004501.37740621
44Arginine and proline metabolism_Homo sapiens_hsa003301.37515434
45Nitrogen metabolism_Homo sapiens_hsa009101.37454422
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33956472
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31529437
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29734927
49Alzheimers disease_Homo sapiens_hsa050101.24599540
50Vitamin digestion and absorption_Homo sapiens_hsa049771.21715767
51Proteasome_Homo sapiens_hsa030501.17607215
52Huntingtons disease_Homo sapiens_hsa050161.17244947
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15321362
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15010271
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13695644
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.13102909
57Bile secretion_Homo sapiens_hsa049761.13028784
58Fatty acid elongation_Homo sapiens_hsa000621.12214736
59Pentose phosphate pathway_Homo sapiens_hsa000301.11516676
60PPAR signaling pathway_Homo sapiens_hsa033201.09640311
61DNA replication_Homo sapiens_hsa030301.08969897
62Ether lipid metabolism_Homo sapiens_hsa005651.07237288
63Type I diabetes mellitus_Homo sapiens_hsa049401.06258611
64SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05520624
65Histidine metabolism_Homo sapiens_hsa003401.04976630
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01450019
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01261918
68Regulation of autophagy_Homo sapiens_hsa041401.00550822
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99731348
70Starch and sucrose metabolism_Homo sapiens_hsa005000.99337938
71Phenylalanine metabolism_Homo sapiens_hsa003600.97087396
72Collecting duct acid secretion_Homo sapiens_hsa049660.95088803
73Metabolic pathways_Homo sapiens_hsa011000.89054120
74One carbon pool by folate_Homo sapiens_hsa006700.87810243
75Fructose and mannose metabolism_Homo sapiens_hsa000510.87714521
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86731558
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.86604612
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84544136
79Chemical carcinogenesis_Homo sapiens_hsa052040.82004599
80Pyrimidine metabolism_Homo sapiens_hsa002400.81966541
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78955456
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77419310
83RNA transport_Homo sapiens_hsa030130.75935579
84Cardiac muscle contraction_Homo sapiens_hsa042600.75207862
85Sphingolipid metabolism_Homo sapiens_hsa006000.69488896
86Asthma_Homo sapiens_hsa053100.65448514
87p53 signaling pathway_Homo sapiens_hsa041150.65304383
88Tyrosine metabolism_Homo sapiens_hsa003500.64693954
89Primary immunodeficiency_Homo sapiens_hsa053400.64515983
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64288046
91Mismatch repair_Homo sapiens_hsa034300.64126410
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.59848537
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.58473285
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56890312
95Glycerolipid metabolism_Homo sapiens_hsa005610.56492847
96Lysine degradation_Homo sapiens_hsa003100.53448936
97RNA polymerase_Homo sapiens_hsa030200.52684511
98Other glycan degradation_Homo sapiens_hsa005110.52230161
99Renin-angiotensin system_Homo sapiens_hsa046140.48134075
100Allograft rejection_Homo sapiens_hsa053300.47272336
101Protein export_Homo sapiens_hsa030600.45097543
102Retinol metabolism_Homo sapiens_hsa008300.44121423
103Insulin secretion_Homo sapiens_hsa049110.43234533
104Autoimmune thyroid disease_Homo sapiens_hsa053200.41948899
105Graft-versus-host disease_Homo sapiens_hsa053320.41449901
106Galactose metabolism_Homo sapiens_hsa000520.41181122
107Ovarian steroidogenesis_Homo sapiens_hsa049130.40897251
108Protein digestion and absorption_Homo sapiens_hsa049740.38629767
109Rheumatoid arthritis_Homo sapiens_hsa053230.36805504
110Mineral absorption_Homo sapiens_hsa049780.30937693
111Purine metabolism_Homo sapiens_hsa002300.30873255
112Olfactory transduction_Homo sapiens_hsa047400.30566323
113Nucleotide excision repair_Homo sapiens_hsa034200.30522579
114Steroid biosynthesis_Homo sapiens_hsa001000.30111982
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30071766
116Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29663830
117Fat digestion and absorption_Homo sapiens_hsa049750.29016150
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.22331687
119Caffeine metabolism_Homo sapiens_hsa002320.22147470
120Complement and coagulation cascades_Homo sapiens_hsa046100.20352179
121Base excision repair_Homo sapiens_hsa034100.17971802
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17391606
123Vitamin B6 metabolism_Homo sapiens_hsa007500.16464514
124ABC transporters_Homo sapiens_hsa020100.15552541
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14144548
126Arachidonic acid metabolism_Homo sapiens_hsa005900.12338801
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.05568522
128Spliceosome_Homo sapiens_hsa030400.05558146
129N-Glycan biosynthesis_Homo sapiens_hsa005100.04206993
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03918437
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.03252688

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