NUDT21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.86068901
2ribosomal small subunit assembly (GO:0000028)4.84684086
3DNA unwinding involved in DNA replication (GO:0006268)4.81880195
4maturation of SSU-rRNA (GO:0030490)4.81478648
5telomere maintenance via semi-conservative replication (GO:0032201)4.64130369
6DNA strand elongation (GO:0022616)4.62416705
7DNA replication initiation (GO:0006270)4.59541785
8mitotic sister chromatid cohesion (GO:0007064)4.55215667
9viral transcription (GO:0019083)4.39630950
10translational termination (GO:0006415)4.31397567
11telomere maintenance via recombination (GO:0000722)4.18807794
12protein localization to kinetochore (GO:0034501)4.17744058
13DNA replication-dependent nucleosome assembly (GO:0006335)4.16495521
14DNA replication-dependent nucleosome organization (GO:0034723)4.16495521
15CENP-A containing nucleosome assembly (GO:0034080)4.15575505
16chromatin remodeling at centromere (GO:0031055)4.15487916
17DNA replication checkpoint (GO:0000076)4.11518057
18DNA ligation (GO:0006266)4.11514430
19mitotic recombination (GO:0006312)4.07184546
20ribosomal large subunit biogenesis (GO:0042273)4.04000360
21ribosomal small subunit biogenesis (GO:0042274)4.00523147
22formation of translation preinitiation complex (GO:0001731)3.98476142
23double-strand break repair via nonhomologous end joining (GO:0006303)3.97291544
24non-recombinational repair (GO:0000726)3.97291544
25translational elongation (GO:0006414)3.95370065
26DNA deamination (GO:0045006)3.92691999
27pore complex assembly (GO:0046931)3.91021125
28mitotic metaphase plate congression (GO:0007080)3.90317805
29DNA replication-independent nucleosome assembly (GO:0006336)3.88125567
30DNA replication-independent nucleosome organization (GO:0034724)3.88125567
31nucleobase biosynthetic process (GO:0046112)3.85644535
32establishment of viral latency (GO:0019043)3.82584006
33translational initiation (GO:0006413)3.80899732
34mitotic nuclear envelope disassembly (GO:0007077)3.80308330
35DNA double-strand break processing (GO:0000729)3.80249980
36telomere maintenance via telomere lengthening (GO:0010833)3.79215912
37nucleotide-excision repair, DNA gap filling (GO:0006297)3.75371348
38kinetochore organization (GO:0051383)3.71990681
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.71744762
40ribonucleoprotein complex biogenesis (GO:0022613)3.70957299
41protein localization to chromosome, centromeric region (GO:0071459)3.70564734
42DNA topological change (GO:0006265)3.70322334
43purine nucleobase biosynthetic process (GO:0009113)3.65808426
44nuclear pore organization (GO:0006999)3.65191747
45folic acid-containing compound biosynthetic process (GO:0009396)3.62547147
46SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.61715031
47spliceosomal snRNP assembly (GO:0000387)3.56387672
48histone exchange (GO:0043486)3.55593684
49ribosome biogenesis (GO:0042254)3.54045107
50nuclear envelope disassembly (GO:0051081)3.53902340
51membrane disassembly (GO:0030397)3.53902340
52cotranslational protein targeting to membrane (GO:0006613)3.52001441
53protein targeting to ER (GO:0045047)3.50443326
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.47208378
55metaphase plate congression (GO:0051310)3.46406346
56somatic diversification of immune receptors via somatic mutation (GO:0002566)3.46296717
57somatic hypermutation of immunoglobulin genes (GO:0016446)3.46296717
58cellular protein complex disassembly (GO:0043624)3.45738655
59regulation of centriole replication (GO:0046599)3.39682882
60mitotic chromosome condensation (GO:0007076)3.38615015
61rRNA processing (GO:0006364)3.37159402
62viral life cycle (GO:0019058)3.36410029
63ribosome assembly (GO:0042255)3.34891199
64IMP biosynthetic process (GO:0006188)3.34338374
65mitotic sister chromatid segregation (GO:0000070)3.34266260
66regulation of mitotic sister chromatid separation (GO:0010965)3.32379768
67regulation of mitotic sister chromatid segregation (GO:0033047)3.32379768
68regulation of sister chromatid segregation (GO:0033045)3.32379768
69nuclear pore complex assembly (GO:0051292)3.32368027
70establishment of protein localization to endoplasmic reticulum (GO:0072599)3.31950297
71regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.31891912
72attachment of spindle microtubules to kinetochore (GO:0008608)3.31064559
73kinetochore assembly (GO:0051382)3.30892064
74regulation of sister chromatid cohesion (GO:0007063)3.30637552
75establishment of chromosome localization (GO:0051303)3.27752552
76rRNA metabolic process (GO:0016072)3.27288582
77negative regulation of DNA recombination (GO:0045910)3.27232381
78protein localization to endoplasmic reticulum (GO:0070972)3.26055359
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25639331
80establishment of integrated proviral latency (GO:0075713)3.23129139
81regulation of spindle organization (GO:0090224)3.23000178
82protein complex disassembly (GO:0043241)3.20128112
83spliceosomal complex assembly (GO:0000245)3.19010873
84sister chromatid segregation (GO:0000819)3.18354257
85L-serine metabolic process (GO:0006563)3.18182586
86chromatin assembly or disassembly (GO:0006333)3.18064007
87protein localization to chromosome (GO:0034502)3.15269882
88transcription-coupled nucleotide-excision repair (GO:0006283)3.14422258
89DNA duplex unwinding (GO:0032508)3.14381222
90regulation of helicase activity (GO:0051095)3.12234488
91DNA geometric change (GO:0032392)3.12211829
92regulation of centrosome cycle (GO:0046605)3.10509726
93nuclear-transcribed mRNA catabolic process (GO:0000956)3.07929428
94negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06621292
95negative regulation of chromosome segregation (GO:0051985)3.06581684
96spindle checkpoint (GO:0031577)3.06486788
97deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.06154995
98negative regulation of mitotic sister chromatid separation (GO:2000816)3.05787942
99negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05787942
100negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05787942
101negative regulation of sister chromatid segregation (GO:0033046)3.05787942
102macromolecular complex disassembly (GO:0032984)3.04862258
103ATP-dependent chromatin remodeling (GO:0043044)3.04411545
104negative regulation of RNA splicing (GO:0033119)3.03493401
105synapsis (GO:0007129)3.03439026
106pre-miRNA processing (GO:0031054)3.03175867
107positive regulation of chromosome segregation (GO:0051984)3.02813771
108spindle assembly checkpoint (GO:0071173)3.02503385
109* RNA splicing, via transesterification reactions (GO:0000375)3.01380685
110* mRNA splicing, via spliceosome (GO:0000398)3.00545947
111* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.00545947
112regulation of chromosome segregation (GO:0051983)2.99965673
113telomere maintenance (GO:0000723)2.98930270
114mitotic spindle assembly checkpoint (GO:0007094)2.98819158
115telomere organization (GO:0032200)2.98475763
116regulation of nuclear cell cycle DNA replication (GO:0033262)2.98067897
117regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97032462
118IMP metabolic process (GO:0046040)2.96389910
119translation (GO:0006412)2.96286874
120translesion synthesis (GO:0019985)2.95634951
121V(D)J recombination (GO:0033151)2.95442366
122negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.95323421
123DNA synthesis involved in DNA repair (GO:0000731)2.94974073
124postreplication repair (GO:0006301)2.94771448
125mitotic spindle checkpoint (GO:0071174)2.94138642
126negative regulation of mRNA processing (GO:0050686)2.92377034
127chromosome segregation (GO:0007059)2.91449575
128regulation of DNA endoreduplication (GO:0032875)2.89162851
129protein complex localization (GO:0031503)2.87374094
130somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.86574052
131somatic cell DNA recombination (GO:0016444)2.86574052
132heterochromatin organization (GO:0070828)2.84156059
133regulation of double-strand break repair via homologous recombination (GO:0010569)2.83389462
134meiotic chromosome segregation (GO:0045132)2.82009192
135regulation of mitotic spindle checkpoint (GO:1903504)2.81447762
136regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.81447762
137mitotic G2/M transition checkpoint (GO:0044818)2.80610309
138paraxial mesoderm development (GO:0048339)2.80477437
139somatic recombination of immunoglobulin gene segments (GO:0016447)2.78326252
140regulation of translational fidelity (GO:0006450)2.78316539
141regulation of histone H3-K9 methylation (GO:0051570)2.78038995
142positive regulation of cell cycle checkpoint (GO:1901978)2.77777046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.02205024
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.47485871
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.43744365
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.00821900
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.69337396
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.31634004
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.12780275
8* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98391307
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93156689
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.88028438
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85875581
12* GABP_17652178_ChIP-ChIP_JURKAT_Human2.77025762
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.66670762
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59605882
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59148121
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.51388778
17XRN2_22483619_ChIP-Seq_HELA_Human2.50507681
18* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48098862
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46829978
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35363328
21VDR_23849224_ChIP-Seq_CD4+_Human2.26842313
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.11069510
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.10956048
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09118818
25AR_21909140_ChIP-Seq_LNCAP_Human2.02746691
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99845605
27* FOXP3_21729870_ChIP-Seq_TREG_Human1.99592076
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99301798
29DCP1A_22483619_ChIP-Seq_HELA_Human1.99146549
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92613000
31* TTF2_22483619_ChIP-Seq_HELA_Human1.91739179
32* GABP_19822575_ChIP-Seq_HepG2_Human1.81354842
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80901346
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80784613
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80081846
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79520568
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79381920
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78649207
39* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76399274
40ELK1_19687146_ChIP-ChIP_HELA_Human1.75890687
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.73808725
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69284364
43* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68854219
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64985246
45* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63328223
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62410525
47* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61882825
48CIITA_25753668_ChIP-Seq_RAJI_Human1.60555584
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57130590
50MYC_22102868_ChIP-Seq_BL_Human1.53346138
51EWS_26573619_Chip-Seq_HEK293_Human1.51812972
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51738608
53* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50497568
54FUS_26573619_Chip-Seq_HEK293_Human1.49443347
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46778369
56IGF1R_20145208_ChIP-Seq_DFB_Human1.46392012
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.44465406
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.43240107
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40141688
60KDM5A_27292631_Chip-Seq_BREAST_Human1.38839600
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38356479
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38132884
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36803872
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.36524971
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.36044214
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33664149
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32248200
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31141796
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29201479
70* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28324606
71* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28241690
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27216044
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24340625
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23440515
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22015064
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20770052
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19509443
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18604761
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18396294
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.13387872
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13345031
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12981924
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09869495
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.09819280
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09584869
86TFEB_21752829_ChIP-Seq_HELA_Human1.07984541
87* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07035184
88* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06795606
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06401232
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06392161
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.06377671
92SOX17_20123909_ChIP-Seq_XEN_Mouse1.06004482
93MYC_18940864_ChIP-ChIP_HL60_Human1.03894805
94TAF15_26573619_Chip-Seq_HEK293_Human1.02531460
95* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01003721
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99433528
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98311455
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95767460
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94403794
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93861788
101TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93701887
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93570240
103* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93249643
104NANOG_21062744_ChIP-ChIP_HESCs_Human0.90312982
105VDR_21846776_ChIP-Seq_THP-1_Human0.88980445
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88955969
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88695729
108IRF1_19129219_ChIP-ChIP_H3396_Human0.87702928
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87640116
110ZNF274_21170338_ChIP-Seq_K562_Hela0.87600134
111KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87593783
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87593783
113KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87593783
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85781075
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85479831
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84902687
117TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84450246
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84233927
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83543376
120TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81935238
121NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.81843622
122SPI1_23547873_ChIP-Seq_NB4_Human0.81491537
123SOX9_26525672_Chip-Seq_HEART_Mouse0.80792325
124REST_19997604_ChIP-ChIP_NEURONS_Mouse0.79955758
125FLI1_27457419_Chip-Seq_LIVER_Mouse0.79904081
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79772617
127* ELK1_22589737_ChIP-Seq_MCF10A_Human0.79286758
128GATA1_26923725_Chip-Seq_HPCs_Mouse0.79049771
129SALL1_21062744_ChIP-ChIP_HESCs_Human0.78660640
130ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.77227210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.17338091
2MP0010094_abnormal_chromosome_stability4.86555165
3MP0004957_abnormal_blastocyst_morpholog4.49088420
4MP0003111_abnormal_nucleus_morphology4.46829399
5MP0003077_abnormal_cell_cycle4.11769682
6MP0008057_abnormal_DNA_replication3.66060862
7MP0008058_abnormal_DNA_repair3.47462546
8MP0008007_abnormal_cellular_replicative3.12106924
9MP0008932_abnormal_embryonic_tissue2.75045262
10MP0003123_paternal_imprinting2.39229774
11MP0001730_embryonic_growth_arrest2.39091753
12MP0000350_abnormal_cell_proliferation2.31813441
13MP0008877_abnormal_DNA_methylation2.25365010
14MP0002396_abnormal_hematopoietic_system2.15735588
15MP0010352_gastrointestinal_tract_polyps2.10645490
16MP0010307_abnormal_tumor_latency1.93867120
17MP0003786_premature_aging1.85854783
18MP0009697_abnormal_copulation1.83710466
19MP0001697_abnormal_embryo_size1.76802772
20MP0010030_abnormal_orbit_morphology1.74333269
21MP0001529_abnormal_vocalization1.71724069
22MP0000490_abnormal_crypts_of1.71304932
23MP0001672_abnormal_embryogenesis/_devel1.68737783
24MP0005380_embryogenesis_phenotype1.68737783
25MP0001188_hyperpigmentation1.66171578
26MP0003890_abnormal_embryonic-extraembry1.65829237
27MP0004808_abnormal_hematopoietic_stem1.59859741
28MP0002080_prenatal_lethality1.59851253
29MP0002085_abnormal_embryonic_tissue1.58409045
30MP0001293_anophthalmia1.56687402
31MP0009379_abnormal_foot_pigmentation1.53952042
32MP0002084_abnormal_developmental_patter1.51974757
33MP0003984_embryonic_growth_retardation1.51560036
34MP0000313_abnormal_cell_death1.49737898
35MP0002088_abnormal_embryonic_growth/wei1.48751241
36MP0002019_abnormal_tumor_incidence1.45730705
37MP0004197_abnormal_fetal_growth/weight/1.39690247
38MP0003121_genomic_imprinting1.37046960
39MP0002086_abnormal_extraembryonic_tissu1.36885820
40MP0006292_abnormal_olfactory_placode1.34532950
41MP0002210_abnormal_sex_determination1.31744953
42MP0002233_abnormal_nose_morphology1.31054978
43MP0006054_spinal_hemorrhage1.26873373
44MP0003567_abnormal_fetal_cardiomyocyte1.25990718
45MP0009333_abnormal_splenocyte_physiolog1.23343186
46MP0003763_abnormal_thymus_physiology1.22038009
47MP0005076_abnormal_cell_differentiation1.21607793
48MP0000703_abnormal_thymus_morphology1.21495148
49MP0003122_maternal_imprinting1.19268160
50MP0001145_abnormal_male_reproductive1.16901863
51MP0003880_abnormal_central_pattern1.11159819
52MP0000537_abnormal_urethra_morphology1.09080672
53MP0005499_abnormal_olfactory_system1.08427409
54MP0005394_taste/olfaction_phenotype1.08427409
55MP0001545_abnormal_hematopoietic_system1.07883401
56MP0005397_hematopoietic_system_phenotyp1.07883401
57MP0006035_abnormal_mitochondrial_morpho1.07735895
58MP0003119_abnormal_digestive_system1.07033486
59MP0002398_abnormal_bone_marrow1.06896096
60MP0003315_abnormal_perineum_morphology1.06893094
61MP0000778_abnormal_nervous_system1.06058287
62MP0003718_maternal_effect1.05742828
63MP0004133_heterotaxia1.05257900
64MP0001177_atelectasis1.04952579
65MP0001929_abnormal_gametogenesis1.03612653
66MP0003385_abnormal_body_wall1.03011072
67MP0003787_abnormal_imprinting0.99500974
68MP0002722_abnormal_immune_system0.97720589
69MP0002653_abnormal_ependyma_morphology0.97687177
70MP0005174_abnormal_tail_pigmentation0.97047720
71MP0009053_abnormal_anal_canal0.97026417
72MP0003755_abnormal_palate_morphology0.96904763
73MP0000653_abnormal_sex_gland0.96502506
74MP0003935_abnormal_craniofacial_develop0.95632226
75MP0000858_altered_metastatic_potential0.91502275
76MP0001346_abnormal_lacrimal_gland0.91137378
77MP0001299_abnormal_eye_distance/0.89776750
78MP0003941_abnormal_skin_development0.89413197
79MP0002234_abnormal_pharynx_morphology0.88953479
80MP0000689_abnormal_spleen_morphology0.88445824
81MP0002938_white_spotting0.88353922
82MP0002160_abnormal_reproductive_system0.86440182
83MP0001286_abnormal_eye_development0.85893026
84MP0002111_abnormal_tail_morphology0.84963650
85MP0002081_perinatal_lethality0.84232809
86MP0000358_abnormal_cell_content/0.84164120
87MP0009672_abnormal_birth_weight0.83721440
88MP0008995_early_reproductive_senescence0.82570473
89MP0005187_abnormal_penis_morphology0.81835342
90MP0002095_abnormal_skin_pigmentation0.81450133
91MP0002132_abnormal_respiratory_system0.79804777
92MP0004811_abnormal_neuron_physiology0.79223949
93MP0002429_abnormal_blood_cell0.78974663
94MP0008789_abnormal_olfactory_epithelium0.77442197
95MP0000631_abnormal_neuroendocrine_gland0.77412866
96MP0002822_catalepsy0.77306326
97MP0000428_abnormal_craniofacial_morphol0.76854497
98MP0003937_abnormal_limbs/digits/tail_de0.76286867
99MP0001119_abnormal_female_reproductive0.75848202
100MP0000432_abnormal_head_morphology0.74823589
101MP0003115_abnormal_respiratory_system0.74710780
102MP0003943_abnormal_hepatobiliary_system0.74638475
103MP0005389_reproductive_system_phenotype0.74262148
104MP0000647_abnormal_sebaceous_gland0.74000037
105MP0010234_abnormal_vibrissa_follicle0.73248988
106MP0002092_abnormal_eye_morphology0.73065450
107MP0006072_abnormal_retinal_apoptosis0.73032509
108MP0002102_abnormal_ear_morphology0.72390183
109MP0002184_abnormal_innervation0.71926782
110MP0003942_abnormal_urinary_system0.70894564
111MP0005384_cellular_phenotype0.70267231
112MP0002152_abnormal_brain_morphology0.69933307
113MP0002177_abnormal_outer_ear0.69690245
114MP0001915_intracranial_hemorrhage0.68263810
115MP0004270_analgesia0.67643550
116MP0009703_decreased_birth_body0.67335489
117MP0000716_abnormal_immune_system0.66053592
118MP0005391_vision/eye_phenotype0.65971024
119MP0002751_abnormal_autonomic_nervous0.65903563
120MP0003938_abnormal_ear_development0.65836608
121MP0002161_abnormal_fertility/fecundity0.65682129
122MP0003221_abnormal_cardiomyocyte_apopto0.65675169
123MP0003186_abnormal_redox_activity0.64055737
124MP0003861_abnormal_nervous_system0.63838269
125MP0002697_abnormal_eye_size0.63819815
126MP0002006_tumorigenesis0.63113491
127MP0000049_abnormal_middle_ear0.62532843
128MP0003806_abnormal_nucleotide_metabolis0.62230767
129MP0002163_abnormal_gland_morphology0.61562422
130MP0001919_abnormal_reproductive_system0.60925101
131MP0005621_abnormal_cell_physiology0.60127798
132MP0000015_abnormal_ear_pigmentation0.59351265
133MP0002075_abnormal_coat/hair_pigmentati0.58274418
134MP0002166_altered_tumor_susceptibility0.57669430
135MP0002009_preneoplasia0.57635804
136MP0003705_abnormal_hypodermis_morpholog0.57109447
137MP0000477_abnormal_intestine_morphology0.57095291
138MP0003698_abnormal_male_reproductive0.56936451

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.09275240
2Birth length less than 3rd percentile (HP:0003561)4.55569662
3Abnormality of cells of the erythroid lineage (HP:0012130)4.41893767
4Abnormal number of erythroid precursors (HP:0012131)4.23135908
5Colon cancer (HP:0003003)4.12084903
6Cortical dysplasia (HP:0002539)3.64955875
7Chromsome breakage (HP:0040012)3.59702846
8Oral leukoplakia (HP:0002745)3.54281406
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.36341843
10Breast hypoplasia (HP:0003187)3.30574491
11Selective tooth agenesis (HP:0001592)3.28171853
12Degeneration of anterior horn cells (HP:0002398)3.28015516
13Abnormality of the anterior horn cell (HP:0006802)3.28015516
14Medulloblastoma (HP:0002885)3.25822925
15Meckel diverticulum (HP:0002245)3.17939615
16Pallor (HP:0000980)3.16848062
17Abnormality of chromosome stability (HP:0003220)3.15479133
18Patellar aplasia (HP:0006443)3.12423132
19Macrocytic anemia (HP:0001972)3.11566204
20Abnormality of the ileum (HP:0001549)3.04510163
21Absent thumb (HP:0009777)2.98873331
22Abnormality of the preputium (HP:0100587)2.97618218
23Aplastic anemia (HP:0001915)2.90998818
24Aplasia/Hypoplasia of the patella (HP:0006498)2.90773701
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.86340764
26Ependymoma (HP:0002888)2.75804658
2711 pairs of ribs (HP:0000878)2.68107069
28Neoplasm of the pancreas (HP:0002894)2.61695865
29Absent radius (HP:0003974)2.58871736
30Small intestinal stenosis (HP:0012848)2.57033950
31Duodenal stenosis (HP:0100867)2.57033950
32Myelodysplasia (HP:0002863)2.56833559
33Rough bone trabeculation (HP:0100670)2.56253925
34Abnormal number of incisors (HP:0011064)2.56066660
35Abnormal lung lobation (HP:0002101)2.54021490
36Supernumerary spleens (HP:0009799)2.50883202
37Premature graying of hair (HP:0002216)2.48600410
38Agnosia (HP:0010524)2.48543522
39Increased nuchal translucency (HP:0010880)2.47013726
40Rhabdomyosarcoma (HP:0002859)2.46311989
41Triphalangeal thumb (HP:0001199)2.43859888
42Microretrognathia (HP:0000308)2.42993491
43Atresia of the external auditory canal (HP:0000413)2.41107307
44Absent forearm bone (HP:0003953)2.40684019
45Aplasia involving forearm bones (HP:0009822)2.40684019
46Tracheoesophageal fistula (HP:0002575)2.39959801
47Basal cell carcinoma (HP:0002671)2.37319682
48Abnormality of the labia minora (HP:0012880)2.36551944
49Carpal bone hypoplasia (HP:0001498)2.36460457
50Abnormality of the carotid arteries (HP:0005344)2.36142087
51Shoulder girdle muscle weakness (HP:0003547)2.35496077
52Short 4th metacarpal (HP:0010044)2.29275592
53Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29275592
54Trismus (HP:0000211)2.27486657
55Thrombocytosis (HP:0001894)2.26735077
56Bone marrow hypocellularity (HP:0005528)2.26336059
57Impulsivity (HP:0100710)2.23232374
58Facial hemangioma (HP:0000329)2.20806622
59Sloping forehead (HP:0000340)2.20056823
60Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18004132
61Cellular immunodeficiency (HP:0005374)2.17164700
62Horseshoe kidney (HP:0000085)2.17035258
63Multiple enchondromatosis (HP:0005701)2.15790521
64Hepatoblastoma (HP:0002884)2.15612805
65Proximal placement of thumb (HP:0009623)2.15125541
66Missing ribs (HP:0000921)2.15111988
67Cleft eyelid (HP:0000625)2.14971394
68Ectopic kidney (HP:0000086)2.14309065
69Atrophy/Degeneration involving motor neurons (HP:0007373)2.12804720
70Abnormality of the duodenum (HP:0002246)2.12732118
71Papillary thyroid carcinoma (HP:0002895)2.11984198
72Aplasia/Hypoplasia of the sternum (HP:0006714)2.09471079
73Deviation of the thumb (HP:0009603)2.07244937
74Cerebral hypomyelination (HP:0006808)2.06872545
75Embryonal neoplasm (HP:0002898)2.05539785
76Optic nerve coloboma (HP:0000588)2.04824980
77Duplicated collecting system (HP:0000081)2.04339513
78Abnormal hair whorl (HP:0010721)2.02537558
79Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.02514162
80Abdominal situs inversus (HP:0003363)2.02449562
81Abnormality of abdominal situs (HP:0011620)2.02449562
82Abnormality of reticulocytes (HP:0004312)2.01091158
83Glossoptosis (HP:0000162)2.00593547
84Short thumb (HP:0009778)1.98154788
85Biliary tract neoplasm (HP:0100574)1.96769117
86Abnormality of DNA repair (HP:0003254)1.93898532
87Neoplasm of the colon (HP:0100273)1.93825500
88Squamous cell carcinoma (HP:0002860)1.92801670
89Microvesicular hepatic steatosis (HP:0001414)1.90207229
90Intestinal atresia (HP:0011100)1.88320788
91Rectovaginal fistula (HP:0000143)1.87141732
92Rectal fistula (HP:0100590)1.87141732
93Skull defect (HP:0001362)1.86485604
94Lymphoma (HP:0002665)1.86003073
95Clitoromegaly (HP:0000057)1.85110405
96Neoplasm of the small intestine (HP:0100833)1.84386631
97Neoplasm of striated muscle (HP:0009728)1.84273474
98Cafe-au-lait spot (HP:0000957)1.84128928
99Abnormality of methionine metabolism (HP:0010901)1.83987448
100Postnatal microcephaly (HP:0005484)1.82699470
101Volvulus (HP:0002580)1.81960813
102Abnormality of the hip-girdle musculature (HP:0001445)1.81114151
103Abnormality of the musculature of the pelvis (HP:0001469)1.81114151
104Insidious onset (HP:0003587)1.80783696
105Termporal pattern (HP:0011008)1.80783696
106Facial cleft (HP:0002006)1.78729111
107Malignant gastrointestinal tract tumors (HP:0006749)1.78586495
108Gastrointestinal carcinoma (HP:0002672)1.78586495
109Astrocytoma (HP:0009592)1.78515192
110Abnormality of the astrocytes (HP:0100707)1.78515192
111Urinary urgency (HP:0000012)1.78094652
112Abnormal trabecular bone morphology (HP:0100671)1.77866776
113Slender long bone (HP:0003100)1.77666770
114Impaired vibration sensation in the lower limbs (HP:0002166)1.77430502
115Nephroblastoma (Wilms tumor) (HP:0002667)1.76751659
116Depressed nasal ridge (HP:0000457)1.76690438
117Glioma (HP:0009733)1.75987081
118Renal duplication (HP:0000075)1.75879068
119Absent eyebrow (HP:0002223)1.75285482
120Neuroblastic tumors (HP:0004376)1.75204006
121Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.75204006
122Neuroblastoma (HP:0003006)1.75204006
123Primitive neuroectodermal tumor (HP:0030065)1.75204006
124Overlapping toe (HP:0001845)1.74763493
125Clubbing of toes (HP:0100760)1.72719178
126Pancytopenia (HP:0001876)1.72129173
127Amaurosis fugax (HP:0100576)1.71989936
128Hypoplasia of the radius (HP:0002984)1.71719662
129Pelvic girdle muscle weakness (HP:0003749)1.71591909
130Spastic diplegia (HP:0001264)1.71552982
131Thyroid carcinoma (HP:0002890)1.69478560
132Cutaneous melanoma (HP:0012056)1.69176205
133Abnormality of glycolysis (HP:0004366)1.68295753
134Embryonal renal neoplasm (HP:0011794)1.68272814
135Progressive external ophthalmoplegia (HP:0000590)1.67144156
136Choanal atresia (HP:0000453)1.64750289
137Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.64649523
138Neoplasm of the oral cavity (HP:0100649)1.63946713
139Hyperglycinemia (HP:0002154)1.63684783
140Ovarian neoplasm (HP:0100615)1.63500642
141Vaginal fistula (HP:0004320)1.61686406
142Increased serum pyruvate (HP:0003542)1.60475133
143Drooling (HP:0002307)1.59312040
144Bifid tongue (HP:0010297)1.59045965
145Arteriovenous malformation (HP:0100026)1.58593848
146Abnormality of chromosome segregation (HP:0002916)1.58110454
147Breast carcinoma (HP:0003002)1.56924034
148High anterior hairline (HP:0009890)1.56875444
149Abnormality of the clitoris (HP:0000056)1.55832082
150Bilateral microphthalmos (HP:0007633)1.54846550
151Abnormality of cochlea (HP:0000375)1.54659684
152Megaloblastic anemia (HP:0001889)1.54415602
153Uterine neoplasm (HP:0010784)1.54378125
154Pancreatic islet-cell hyperplasia (HP:0004510)1.54367224

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.67022766
2CDC74.34424871
3WEE14.13819876
4EIF2AK13.28639188
5SRPK12.86111501
6NEK22.82722506
7TLK12.80489638
8ACVR1B2.65139724
9BCR2.57541754
10TRIM282.39072692
11NME22.32214155
12VRK12.08780450
13NEK12.04815753
14PLK12.03982992
15TTK2.00616911
16TSSK61.96230506
17MKNK11.92119260
18BRSK21.92087984
19TESK21.91703261
20DYRK31.85111872
21ATR1.76535050
22AURKB1.74630568
23CDK71.72925929
24PASK1.71587193
25RPS6KA41.71556380
26STK161.69218836
27PLK41.67837402
28EIF2AK31.66419212
29ERBB31.57141214
30SCYL21.54889480
31TAF11.52461331
32PLK31.50995568
33MAP3K41.48785771
34RPS6KB21.48655157
35BRSK11.47814977
36MKNK21.41662418
37PNCK1.40487328
38CHEK21.37075949
39AURKA1.33427306
40WNK31.33007409
41MAP3K101.32045367
42CDK121.31416642
43MAP3K81.23277899
44STK101.22077142
45STK41.22034644
46CDK41.21092293
47CHEK11.20210131
48ZAK1.17347057
49MST41.15476608
50EEF2K1.10832314
51PAK41.10769268
52CDK191.10640932
53FLT31.07309485
54TGFBR11.06927501
55TESK11.05524448
56LATS11.02985808
57CCNB11.02794565
58PBK0.97409731
59VRK20.95997146
60PIM10.92298269
61CASK0.92268820
62MAP2K70.91176623
63ATM0.89825334
64CSNK1G10.86986480
65STK38L0.86160707
66CDK20.85690823
67LRRK20.83375728
68MINK10.81087874
69PKN20.79058289
70PIM20.78977505
71ALK0.77629091
72EPHA20.72931562
73CDK60.72668782
74CSNK1G30.72538881
75EIF2AK20.72521452
76CSNK2A20.71521784
77TNIK0.71481687
78CSNK1G20.70762314
79EPHA40.70566776
80NUAK10.69302956
81UHMK10.68278442
82MELK0.68138213
83MARK10.68062314
84CDK140.67929356
85CSNK1A1L0.67737099
86ERBB40.66439141
87PAK10.66311987
88CSNK2A10.66285585
89CDK10.66239503
90MAP4K10.65953159
91CDK80.65839206
92RPS6KA50.64459280
93CDK30.61765948
94PLK20.59880520
95KSR10.59825303
96BRD40.58892001
97DYRK20.57666847
98CLK10.57017783
99YES10.55096160
100LIMK10.54232536
101PRKCI0.54087783
102KDR0.53623932
103NME10.47213301
104ILK0.45468519
105BMPR1B0.41361785
106AKT20.40136972
107BRAF0.36507866
108PRKDC0.35717260
109SIK30.35148561
110BTK0.33695085
111CSNK1D0.32831471
112STK240.31889896
113TEC0.31621187
114NEK90.31530244
115FGFR10.31311301
116CDK90.30992899
117PDGFRA0.30313704
118MAPK130.30093433
119GSK3B0.29535635
120STK30.28625156
121MAP3K110.28301075
122IRAK40.27659361
123CSNK1E0.27313836
124GRK60.26886592
125DYRK1B0.26252664
126CDK11A0.25714386
127ABL20.24496684
128RPS6KA10.22195122
129CDK180.20923772
130CDK150.20264461
131AKT10.19947010
132PDK40.19722503
133PDK30.19722503
134ZAP700.19496077
135TAOK20.19486945
136RPS6KB10.18610893
137LATS20.18535708
138MAPK140.18460860

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.12827694
2Mismatch repair_Homo sapiens_hsa034304.37755845
3Ribosome_Homo sapiens_hsa030103.90719744
4Spliceosome_Homo sapiens_hsa030403.56116506
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.52191749
6Homologous recombination_Homo sapiens_hsa034403.10640256
7RNA polymerase_Homo sapiens_hsa030203.08481241
8RNA transport_Homo sapiens_hsa030133.05123503
9Base excision repair_Homo sapiens_hsa034103.04358665
10Nucleotide excision repair_Homo sapiens_hsa034203.01247260
11Proteasome_Homo sapiens_hsa030503.00744796
12Cell cycle_Homo sapiens_hsa041102.76324213
13One carbon pool by folate_Homo sapiens_hsa006702.61882183
14Pyrimidine metabolism_Homo sapiens_hsa002402.40619270
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.35784239
16Fanconi anemia pathway_Homo sapiens_hsa034602.31870716
17Non-homologous end-joining_Homo sapiens_hsa034502.02784894
18Basal transcription factors_Homo sapiens_hsa030221.94306709
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85701173
20RNA degradation_Homo sapiens_hsa030181.85171564
21* mRNA surveillance pathway_Homo sapiens_hsa030151.79114117
22Systemic lupus erythematosus_Homo sapiens_hsa053221.78433804
23p53 signaling pathway_Homo sapiens_hsa041151.58148342
24Steroid biosynthesis_Homo sapiens_hsa001001.53992980
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41843347
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27197437
27Purine metabolism_Homo sapiens_hsa002301.23872705
28Epstein-Barr virus infection_Homo sapiens_hsa051691.20118913
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16604051
30Propanoate metabolism_Homo sapiens_hsa006401.12578255
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08578341
32Viral carcinogenesis_Homo sapiens_hsa052031.08549407
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07135916
34Pyruvate metabolism_Homo sapiens_hsa006201.06413772
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06162735
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02641199
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02296024
38Oocyte meiosis_Homo sapiens_hsa041140.99288520
39Antigen processing and presentation_Homo sapiens_hsa046120.98585950
40Herpes simplex infection_Homo sapiens_hsa051680.98165327
41Alcoholism_Homo sapiens_hsa050340.86297801
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85621064
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84448583
44HTLV-I infection_Homo sapiens_hsa051660.83534469
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82431620
46Nicotine addiction_Homo sapiens_hsa050330.76364968
47Pentose phosphate pathway_Homo sapiens_hsa000300.74006393
48Thyroid cancer_Homo sapiens_hsa052160.73589072
49MicroRNAs in cancer_Homo sapiens_hsa052060.68890815
50Legionellosis_Homo sapiens_hsa051340.67309889
51Lysine degradation_Homo sapiens_hsa003100.60397111
52Protein export_Homo sapiens_hsa030600.58732202
53Selenocompound metabolism_Homo sapiens_hsa004500.58656437
54Biosynthesis of amino acids_Homo sapiens_hsa012300.58540923
55Primary immunodeficiency_Homo sapiens_hsa053400.57845035
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.57645703
57Colorectal cancer_Homo sapiens_hsa052100.57598704
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.57551845
59Folate biosynthesis_Homo sapiens_hsa007900.57164558
60Huntingtons disease_Homo sapiens_hsa050160.57134106
61Basal cell carcinoma_Homo sapiens_hsa052170.56178058
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56175082
63Small cell lung cancer_Homo sapiens_hsa052220.55413218
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55108676
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53009167
66Hippo signaling pathway_Homo sapiens_hsa043900.49634257
67Sulfur relay system_Homo sapiens_hsa041220.48188953
68Chronic myeloid leukemia_Homo sapiens_hsa052200.47032021
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45836201
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45511573
71Apoptosis_Homo sapiens_hsa042100.45498065
72TGF-beta signaling pathway_Homo sapiens_hsa043500.45467079
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44835128
74Measles_Homo sapiens_hsa051620.44261754
75Tight junction_Homo sapiens_hsa045300.43737855
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.42928568
77Shigellosis_Homo sapiens_hsa051310.42208383
78Hepatitis B_Homo sapiens_hsa051610.41908092
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41730641
80Bladder cancer_Homo sapiens_hsa052190.40101421
81N-Glycan biosynthesis_Homo sapiens_hsa005100.39915736
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38984748
83Notch signaling pathway_Homo sapiens_hsa043300.37895941
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36449407
85Fatty acid elongation_Homo sapiens_hsa000620.36161233
86Parkinsons disease_Homo sapiens_hsa050120.34308074
87GABAergic synapse_Homo sapiens_hsa047270.33489105
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.32106013
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31714415
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30143381
91Viral myocarditis_Homo sapiens_hsa054160.29557114
92Pathways in cancer_Homo sapiens_hsa052000.28836634
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.28398996
94Taste transduction_Homo sapiens_hsa047420.27750448
95Butanoate metabolism_Homo sapiens_hsa006500.27545806
96Hedgehog signaling pathway_Homo sapiens_hsa043400.27298179
97Non-small cell lung cancer_Homo sapiens_hsa052230.25539313
98Acute myeloid leukemia_Homo sapiens_hsa052210.24991817
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24919403
100HIF-1 signaling pathway_Homo sapiens_hsa040660.24867445
101Dopaminergic synapse_Homo sapiens_hsa047280.24865869
102Gap junction_Homo sapiens_hsa045400.24711832
103Metabolic pathways_Homo sapiens_hsa011000.24171299
104Carbon metabolism_Homo sapiens_hsa012000.23457944
105Adherens junction_Homo sapiens_hsa045200.23408554
106Influenza A_Homo sapiens_hsa051640.23267150
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22512275
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21943378
109Glutathione metabolism_Homo sapiens_hsa004800.21537578
110Fatty acid metabolism_Homo sapiens_hsa012120.21012596
111Axon guidance_Homo sapiens_hsa043600.20688804
112Wnt signaling pathway_Homo sapiens_hsa043100.19077917
113Circadian rhythm_Homo sapiens_hsa047100.18557786
114AMPK signaling pathway_Homo sapiens_hsa041520.18271219
115Glioma_Homo sapiens_hsa052140.17501951
116Prostate cancer_Homo sapiens_hsa052150.17456667
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.16652072
118Arginine and proline metabolism_Homo sapiens_hsa003300.16633797
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.16083545
120Hematopoietic cell lineage_Homo sapiens_hsa046400.15716254
121Vitamin B6 metabolism_Homo sapiens_hsa007500.15223142
122Melanogenesis_Homo sapiens_hsa049160.15118018
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14635558
124Allograft rejection_Homo sapiens_hsa053300.14499661
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14358915
126Graft-versus-host disease_Homo sapiens_hsa053320.14246023
127ErbB signaling pathway_Homo sapiens_hsa040120.14102988
128Melanoma_Homo sapiens_hsa052180.13985834
129Endometrial cancer_Homo sapiens_hsa052130.13896073
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.13821959
131Asthma_Homo sapiens_hsa053100.12827214
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.11842229
133T cell receptor signaling pathway_Homo sapiens_hsa046600.11762354
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.11093778
135Pancreatic cancer_Homo sapiens_hsa052120.10584788
136mTOR signaling pathway_Homo sapiens_hsa041500.10113853
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.09526827
138FoxO signaling pathway_Homo sapiens_hsa040680.08338759

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