NUDT22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.60555204
2exocrine pancreas development (GO:0031017)4.72571508
3L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.56613129
4protein complex biogenesis (GO:0070271)4.43764914
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.38863278
6oxidative phosphorylation (GO:0006119)4.37102514
7protein retention in ER lumen (GO:0006621)4.36567743
8proteasome assembly (GO:0043248)4.25873129
9amino acid salvage (GO:0043102)4.18264479
10L-methionine salvage (GO:0071267)4.18264479
11L-methionine biosynthetic process (GO:0071265)4.18264479
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.16774217
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.03399086
14ATP synthesis coupled proton transport (GO:0015986)4.03399086
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.01457469
16mitochondrial respiratory chain complex assembly (GO:0033108)3.99274768
17proline biosynthetic process (GO:0006561)3.98924317
18formation of translation preinitiation complex (GO:0001731)3.96728338
19cotranslational protein targeting to membrane (GO:0006613)3.96400309
20protein targeting to ER (GO:0045047)3.95050356
21branched-chain amino acid catabolic process (GO:0009083)3.94650719
22GDP-mannose metabolic process (GO:0019673)3.92656323
23intestinal cholesterol absorption (GO:0030299)3.91102930
24protein localization to endoplasmic reticulum (GO:0070972)3.82780950
25establishment of protein localization to endoplasmic reticulum (GO:0072599)3.77295094
26viral transcription (GO:0019083)3.76999337
27ribosomal small subunit assembly (GO:0000028)3.74119718
28maturation of SSU-rRNA (GO:0030490)3.73426484
29valine metabolic process (GO:0006573)3.69799887
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.69107400
31translational termination (GO:0006415)3.68857125
32proline metabolic process (GO:0006560)3.68048031
33cytochrome complex assembly (GO:0017004)3.63794026
34purine deoxyribonucleotide catabolic process (GO:0009155)3.60103482
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.56115768
36mannosylation (GO:0097502)3.55293056
37translation (GO:0006412)3.55132071
38sulfur amino acid biosynthetic process (GO:0000097)3.51670453
39branched-chain amino acid metabolic process (GO:0009081)3.51602129
40base-excision repair, AP site formation (GO:0006285)3.49822620
41transcription elongation from RNA polymerase III promoter (GO:0006385)3.47666907
42termination of RNA polymerase III transcription (GO:0006386)3.47666907
43translational elongation (GO:0006414)3.47460075
44galactose catabolic process (GO:0019388)3.43382762
45response to interferon-beta (GO:0035456)3.39036923
46respiratory chain complex IV assembly (GO:0008535)3.37941959
47respiratory electron transport chain (GO:0022904)3.37628487
48NADH metabolic process (GO:0006734)3.34995458
49deoxyribonucleotide catabolic process (GO:0009264)3.33773355
50regulation of mitochondrial translation (GO:0070129)3.32717453
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32547216
52ribosomal small subunit biogenesis (GO:0042274)3.31404198
53regulation of cellular amino acid metabolic process (GO:0006521)3.31202611
54cysteine metabolic process (GO:0006534)3.28793909
55electron transport chain (GO:0022900)3.28764349
56negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.22220663
57serine family amino acid biosynthetic process (GO:0009070)3.21756989
58pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.21492207
59translational initiation (GO:0006413)3.20147676
60deoxyribose phosphate catabolic process (GO:0046386)3.19047734
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.18720948
62mitochondrial calcium ion transport (GO:0006851)3.17072883
63methionine biosynthetic process (GO:0009086)3.16815839
64digestion (GO:0007586)3.16619581
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14859327
66aspartate family amino acid biosynthetic process (GO:0009067)3.14351664
67negative regulation of B cell apoptotic process (GO:0002903)3.11354185
68quinone biosynthetic process (GO:1901663)3.10242482
69ubiquinone biosynthetic process (GO:0006744)3.10242482
70cellular response to interferon-beta (GO:0035458)3.07563436
71peptidyl-histidine modification (GO:0018202)3.06641483
72Golgi transport vesicle coating (GO:0048200)3.06240114
73COPI coating of Golgi vesicle (GO:0048205)3.06240114
74autophagic vacuole fusion (GO:0000046)3.05866397
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.03044381
76negative regulation of ligase activity (GO:0051352)3.03044381
77cytidine deamination (GO:0009972)3.02757290
78cytidine metabolic process (GO:0046087)3.02757290
79cytidine catabolic process (GO:0006216)3.02757290
80transcytosis (GO:0045056)3.02199114
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01714437
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01510619
83metallo-sulfur cluster assembly (GO:0031163)3.01381160
84iron-sulfur cluster assembly (GO:0016226)3.01381160
85antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.98763169
86ribosomal large subunit biogenesis (GO:0042273)2.98361136
87L-serine metabolic process (GO:0006563)2.98118687
88nucleobase biosynthetic process (GO:0046112)2.96842758
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96223075
90mitochondrial respiratory chain complex I assembly (GO:0032981)2.96223075
91NADH dehydrogenase complex assembly (GO:0010257)2.96223075
92signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.95932126
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.95932126
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.95932126
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.95752129
96intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.95752129
97rRNA modification (GO:0000154)2.95582615
98GTP biosynthetic process (GO:0006183)2.95196241
99signal peptide processing (GO:0006465)2.93610415
100heme biosynthetic process (GO:0006783)2.93515497
101glycine metabolic process (GO:0006544)2.92225221
102purine nucleobase biosynthetic process (GO:0009113)2.91977776
103aspartate family amino acid catabolic process (GO:0009068)2.90259961
104anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.89404037
105viral life cycle (GO:0019058)2.89014567
106signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88103766
107signal transduction involved in DNA damage checkpoint (GO:0072422)2.88103766
108cobalamin metabolic process (GO:0009235)2.88032671
109methionine metabolic process (GO:0006555)2.87856409
110protein-cofactor linkage (GO:0018065)2.86906102
111RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85201726
112tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85201726
113aspartate family amino acid metabolic process (GO:0009066)2.85168698
114erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.83901059
115L-phenylalanine metabolic process (GO:0006558)2.83901059
116signal transduction involved in cell cycle checkpoint (GO:0072395)2.82049776
117cellular protein complex disassembly (GO:0043624)2.81624477
1184-hydroxyproline metabolic process (GO:0019471)2.81316535
119folic acid metabolic process (GO:0046655)2.80131329
120regulation of translation in response to stress (GO:0043555)2.80051071
121chaperone-mediated protein transport (GO:0072321)2.77335572
122C-terminal protein lipidation (GO:0006501)2.75960901
123regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.73814771
124ubiquinone metabolic process (GO:0006743)2.72758177
125immunoglobulin mediated immune response (GO:0016064)2.72341637
126establishment of protein localization to mitochondrial membrane (GO:0090151)2.68858196
127purine deoxyribonucleotide metabolic process (GO:0009151)2.67846852
128organelle membrane fusion (GO:0090174)2.67028572
129positive regulation of prostaglandin secretion (GO:0032308)2.66548280
130negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.66508655
131antigen processing and presentation of endogenous antigen (GO:0019883)2.63526223
132regulation of B cell apoptotic process (GO:0002902)2.63479883
133positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.61873740
134pyrimidine nucleotide catabolic process (GO:0006244)2.61852098
135preassembly of GPI anchor in ER membrane (GO:0016254)2.61795291
136purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.58317567
137purine nucleoside triphosphate biosynthetic process (GO:0009145)2.56694235
138pentose metabolic process (GO:0019321)2.55648533
139rRNA methylation (GO:0031167)2.54220480
140Arp2/3 complex-mediated actin nucleation (GO:0034314)2.53993817
141NIK/NF-kappaB signaling (GO:0038061)2.52907991
142positive regulation of protein homooligomerization (GO:0032464)2.51984250
143GPI anchor biosynthetic process (GO:0006506)2.51750512
144pyrimidine ribonucleoside catabolic process (GO:0046133)2.50954684
145UTP biosynthetic process (GO:0006228)2.50394694
146nucleotide salvage (GO:0043173)2.48786032
147pseudouridine synthesis (GO:0001522)2.48071298
148guanosine-containing compound biosynthetic process (GO:1901070)2.47970606
149negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.46772843
150ATP biosynthetic process (GO:0006754)2.46671670
151protein targeting to mitochondrion (GO:0006626)2.45692620
1522-deoxyribonucleotide metabolic process (GO:0009394)2.44554736
153positive regulation of T cell mediated cytotoxicity (GO:0001916)2.44381894
154UV protection (GO:0009650)2.41674091
155viral protein processing (GO:0019082)2.41085878
156establishment of protein localization to mitochondrion (GO:0072655)2.39959257
157hydrogen ion transmembrane transport (GO:1902600)2.38870812
158regulation of defense response to virus by host (GO:0050691)2.36819495
159deoxyribose phosphate metabolic process (GO:0019692)2.36810493
160positive regulation of defense response to virus by host (GO:0002230)2.36513805
161regulation of interferon-beta biosynthetic process (GO:0045357)2.36087388
162regulation of autophagic vacuole assembly (GO:2000785)2.34969146
163tRNA modification (GO:0006400)2.34426240
164virion assembly (GO:0019068)2.34109615
165positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.33450051
166mature B cell differentiation involved in immune response (GO:0002313)2.33019774
167response to misfolded protein (GO:0051788)2.32690369
168platelet dense granule organization (GO:0060155)2.31315025
169positive regulation of lymphocyte apoptotic process (GO:0070230)2.31114315
170antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.30986200
171positive regulation of T cell apoptotic process (GO:0070234)2.29866628
172protein insertion into membrane (GO:0051205)2.29686199
173purinergic nucleotide receptor signaling pathway (GO:0035590)2.27977547
174negative regulation of telomere maintenance (GO:0032205)2.27613896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91717965
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65462586
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.49074164
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.42224274
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.38339388
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.34339629
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.29194548
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.07786298
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.96153063
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.90911463
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74788727
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.62436885
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.47317220
14VDR_21846776_ChIP-Seq_THP-1_Human2.46171162
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.45542933
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41056559
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.27722845
18E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23626396
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22482498
20BCL6_27268052_Chip-Seq_Bcells_Human2.17711807
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17254931
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16638732
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.14694794
24DCP1A_22483619_ChIP-Seq_HELA_Human2.11832309
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08314088
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06379912
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04817612
28VDR_23849224_ChIP-Seq_CD4+_Human1.99900771
29XRN2_22483619_ChIP-Seq_HELA_Human1.99817830
30LXR_22292898_ChIP-Seq_THP-1_Human1.99428549
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.98715645
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98579104
33ELF1_20517297_ChIP-Seq_JURKAT_Human1.96506367
34P68_20966046_ChIP-Seq_HELA_Human1.91443764
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88802929
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87372733
37BCOR_27268052_Chip-Seq_Bcells_Human1.87016809
38GABP_19822575_ChIP-Seq_HepG2_Human1.83371478
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83146774
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82070775
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81737584
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.75943553
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.75664198
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72071218
45FOXP3_21729870_ChIP-Seq_TREG_Human1.69812664
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67305083
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66810381
48MAF_26560356_Chip-Seq_TH2_Human1.65425994
49E2F1_20622854_ChIP-Seq_HELA_Human1.63609467
50BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.60177466
51E2F7_22180533_ChIP-Seq_HELA_Human1.57532324
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.53769066
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52171425
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51598675
55* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50698401
56PHF8_20622854_ChIP-Seq_HELA_Human1.50458181
57CTCF_26484167_Chip-Seq_Bcells_Mouse1.50164668
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48622703
59RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47822195
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47716662
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45927488
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.45903465
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44844932
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44067125
65CTCF_20526341_ChIP-Seq_ESCs_Human1.43527623
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43047088
67VDR_24763502_ChIP-Seq_THP-1_Human1.41734488
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41695340
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.40715016
70P300_27268052_Chip-Seq_Bcells_Human1.40117456
71MAF_26560356_Chip-Seq_TH1_Human1.39728575
72SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38716680
73RXR_22158963_ChIP-Seq_LIVER_Mouse1.38427427
74TTF2_22483619_ChIP-Seq_HELA_Human1.37803949
75GATA1_22025678_ChIP-Seq_K562_Human1.37514098
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37185833
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36970946
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36567168
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35574196
80UTX_26944678_Chip-Seq_JUKART_Human1.35274735
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35042329
82CIITA_25753668_ChIP-Seq_RAJI_Human1.34855431
83IRF8_21731497_ChIP-ChIP_J774_Mouse1.32359762
84* SA1_27219007_Chip-Seq_ERYTHROID_Human1.30429783
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30266261
86SPI1_23547873_ChIP-Seq_NB4_Human1.29514383
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29277514
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28704860
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27195522
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26634168
91MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26255499
92MYC_22102868_ChIP-Seq_BL_Human1.26060432
93ERA_21632823_ChIP-Seq_H3396_Human1.25753962
94SA1_27219007_Chip-Seq_Bcells_Human1.24520012
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.23987888
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23055033
97RARB_24833708_ChIP-Seq_LIVER_Mouse1.22488975
98CTCF_21964334_Chip-Seq_Bcells_Human1.22411573
99RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22095975
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21691882
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21416000
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20973945
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20770578
104HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20729318
105SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19438615
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18708961
107CTCF_21964334_ChIP-Seq_BJAB-B_Human1.17772904
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16032158
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16029811
110CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15294568
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15071720
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14003261
113LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13553020
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13521302
115SPI1_20517297_ChIP-Seq_HL60_Human1.13369831
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12923792
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12042220
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11645047
119ELK1_19687146_ChIP-ChIP_HELA_Human1.10752223
120RACK7_27058665_Chip-Seq_MCF-7_Human1.09947667
121BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.09805531
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08989364
123* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08985843
124TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08086820
125SMC4_20622854_ChIP-Seq_HELA_Human1.07771686
126NANOG_20526341_ChIP-Seq_ESCs_Human1.07548707
127RARA_24833708_ChIP-Seq_LIVER_Mouse1.06850951
128* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06317962
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05309431
130MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04481305
131KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04170971
132GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04004881
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02593620
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01812469
135POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01663780
136AR_21909140_ChIP-Seq_LNCAP_Human1.00804380
137KDM5A_27292631_Chip-Seq_BREAST_Human0.99547929
138CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99154429
139KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97402234
140SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97273320
141KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96493323
142KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96493323
143KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96493323
144OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96221568
145FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95336482
146SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94789633
147TFEB_21752829_ChIP-Seq_HELA_Human0.94775041
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.93813986
149DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91011028
150FOXP1_21924763_ChIP-Seq_HESCs_Human0.90474222
151CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90152584
152TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88705567
153EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88003508
154TET1_21451524_ChIP-Seq_MESCs_Mouse0.87664898

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.42700915
2MP0005083_abnormal_biliary_tract4.02916853
3MP0001666_abnormal_nutrient_absorption3.95838492
4MP0005365_abnormal_bile_salt3.71056780
5MP0003693_abnormal_embryo_hatching3.27507858
6MP0003186_abnormal_redox_activity3.14205816
7MP0005451_abnormal_body_composition2.83162201
8MP0009840_abnormal_foam_cell2.82628323
9MP0005220_abnormal_exocrine_pancreas2.68437252
10MP0003436_decreased_susceptibility_to2.66288263
11MP0005671_abnormal_response_to2.61637633
12MP0001835_abnormal_antigen_presentation2.51399460
13MP0006036_abnormal_mitochondrial_physio2.49723016
14MP0005332_abnormal_amino_acid2.47806658
15MP0005084_abnormal_gallbladder_morpholo2.45475949
16MP0003656_abnormal_erythrocyte_physiolo2.44428971
17MP0000685_abnormal_immune_system2.43760829
18MP0002837_dystrophic_cardiac_calcinosis2.29419447
19MP0002148_abnormal_hypersensitivity_rea2.25824498
20MP0005085_abnormal_gallbladder_physiolo2.21900357
21MP0005387_immune_system_phenotype2.19768149
22MP0001790_abnormal_immune_system2.19768149
23MP0001800_abnormal_humoral_immune2.18230911
24MP0005025_abnormal_response_to2.12408081
25MP0004957_abnormal_blastocyst_morpholog2.08702834
26MP0000372_irregular_coat_pigmentation2.08688501
27MP0002723_abnormal_immune_serum2.05690119
28MP0009785_altered_susceptibility_to2.01885317
29MP0001764_abnormal_homeostasis2.00135845
30MP0002139_abnormal_hepatobiliary_system1.99215047
31MP0000749_muscle_degeneration1.97356817
32MP0005000_abnormal_immune_tolerance1.95551507
33MP0004147_increased_porphyrin_level1.88386493
34MP0000015_abnormal_ear_pigmentation1.85919885
35MP0002420_abnormal_adaptive_immunity1.85393602
36MP0001819_abnormal_immune_cell1.84473129
37MP0002452_abnormal_antigen_presenting1.83798635
38MP0006035_abnormal_mitochondrial_morpho1.77627435
39MP0005330_cardiomyopathy1.76465492
40MP0003172_abnormal_lysosome_physiology1.75559097
41MP0004084_abnormal_cardiac_muscle1.74268942
42MP0000750_abnormal_muscle_regeneration1.72674893
43MP0009643_abnormal_urine_homeostasis1.69110697
44MP0002653_abnormal_ependyma_morphology1.62526339
45MP0003763_abnormal_thymus_physiology1.61038958
46MP0002419_abnormal_innate_immunity1.59874106
47MP0008875_abnormal_xenobiotic_pharmacok1.59493569
48MP0002138_abnormal_hepatobiliary_system1.57255806
49MP0005058_abnormal_lysosome_morphology1.48279534
50MP0003718_maternal_effect1.47107761
51MP0005360_urolithiasis1.45536139
52MP0003191_abnormal_cellular_cholesterol1.44437504
53MP0009333_abnormal_splenocyte_physiolog1.44101678
54MP0000716_abnormal_immune_system1.43374048
55MP0002269_muscular_atrophy1.40506751
56MP0010155_abnormal_intestine_physiology1.40469575
57MP0002163_abnormal_gland_morphology1.37585655
58MP0005464_abnormal_platelet_physiology1.37102595
59MP0005319_abnormal_enzyme/_coenzyme1.36803916
60MP0005174_abnormal_tail_pigmentation1.36800315
61MP0004381_abnormal_hair_follicle1.32701453
62MP0003195_calcinosis1.30377783
63MP0000358_abnormal_cell_content/1.29583483
64MP0000689_abnormal_spleen_morphology1.28592403
65MP0000678_abnormal_parathyroid_gland1.28584139
66MP0002398_abnormal_bone_marrow1.27141161
67MP0009278_abnormal_bone_marrow1.26617595
68MP0004036_abnormal_muscle_relaxation1.26412910
69MP0002405_respiratory_system_inflammati1.24669404
70MP0003011_delayed_dark_adaptation1.23842167
71MP0002429_abnormal_blood_cell1.23730479
72MP0002277_abnormal_respiratory_mucosa1.21545787
73MP0002132_abnormal_respiratory_system1.21287988
74MP0005410_abnormal_fertilization1.20513007
75MP0001756_abnormal_urination1.20000555
76MP0002722_abnormal_immune_system1.19183454
77MP0001968_abnormal_touch/_nociception1.18569298
78MP0001905_abnormal_dopamine_level1.17699899
79MP0009764_decreased_sensitivity_to1.16791677
80MP0003724_increased_susceptibility_to1.15986925
81MP0005636_abnormal_mineral_homeostasis1.14839439
82MP0005408_hypopigmentation1.13608270
83MP0004215_abnormal_myocardial_fiber1.12879449
84MP0005645_abnormal_hypothalamus_physiol1.12041524
85MP0000747_muscle_weakness1.08196348
86MP0001663_abnormal_digestive_system1.07292652
87MP0003303_peritoneal_inflammation1.06859262
88MP0004043_abnormal_pH_regulation1.06595992
89MP0003868_abnormal_feces_composition1.04424277
90MP0003111_abnormal_nucleus_morphology1.02942477
91MP0002933_joint_inflammation1.02176288
92MP0006082_CNS_inflammation1.01722406
93MP0002118_abnormal_lipid_homeostasis1.00064639
94MP0008438_abnormal_cutaneous_collagen0.99952772
95MP0008260_abnormal_autophagy0.98643345
96MP0000598_abnormal_liver_morphology0.98439777
97MP0000538_abnormal_urinary_bladder0.97825629
98MP0008872_abnormal_physiological_respon0.97493459
99MP0003941_abnormal_skin_development0.97409873
100MP0003077_abnormal_cell_cycle0.97173449
101MP0002396_abnormal_hematopoietic_system0.96518012
102MP0000609_abnormal_liver_physiology0.96273417
103MP0001533_abnormal_skeleton_physiology0.95769559
104MP0002736_abnormal_nociception_after0.95412593
105MP0000703_abnormal_thymus_morphology0.95144592
106MP0005165_increased_susceptibility_to0.95076794
107MP0001664_abnormal_digestion0.94567534
108MP0005367_renal/urinary_system_phenotyp0.91500498
109MP0000516_abnormal_urinary_system0.91500498
110MP0002972_abnormal_cardiac_muscle0.91233938
111MP0002876_abnormal_thyroid_physiology0.91078310
112MP0008469_abnormal_protein_level0.90920694
113MP0003646_muscle_fatigue0.90481421
114MP0000490_abnormal_crypts_of0.90048983
115MP0000681_abnormal_thyroid_gland0.87926378
116MP0010094_abnormal_chromosome_stability0.86974996
117MP0002234_abnormal_pharynx_morphology0.85904638
118MP0003075_altered_response_to0.84746565
119MP0004264_abnormal_extraembryonic_tissu0.83986067
120MP0008932_abnormal_embryonic_tissue0.83707265
121MP0005584_abnormal_enzyme/coenzyme_acti0.82950420
122MP0003638_abnormal_response/metabolism_0.81742890
123MP0005376_homeostasis/metabolism_phenot0.81493410
124MP0005266_abnormal_metabolism0.81449173
125MP0010329_abnormal_lipoprotein_level0.81169423
126MP0003137_abnormal_impulse_conducting0.80491095
127MP0002693_abnormal_pancreas_physiology0.79745900
128MP0004233_abnormal_muscle_weight0.79495993
129MP0009384_cardiac_valve_regurgitation0.79254793
130MP0004019_abnormal_vitamin_homeostasis0.78584571
131MP0003866_abnormal_defecation0.78506881
132MP0003878_abnormal_ear_physiology0.77458286
133MP0005377_hearing/vestibular/ear_phenot0.77458286
134MP0000343_altered_response_to0.77162538
135MP0005166_decreased_susceptibility_to0.76773388
136MP0002136_abnormal_kidney_physiology0.76630007
137MP0000858_altered_metastatic_potential0.76233950
138MP0002019_abnormal_tumor_incidence0.75506945
139MP0002095_abnormal_skin_pigmentation0.75166680
140MP0001986_abnormal_taste_sensitivity0.75143709
141MP0005670_abnormal_white_adipose0.72447845
142MP0001853_heart_inflammation0.70875222
143MP0005023_abnormal_wound_healing0.69879306
144MP0008058_abnormal_DNA_repair0.69701453
145MP0001544_abnormal_cardiovascular_syste0.68810794
146MP0005385_cardiovascular_system_phenoty0.68810794
147MP0005075_abnormal_melanosome_morpholog0.67723561
148MP0010630_abnormal_cardiac_muscle0.67120925
149MP0003950_abnormal_plasma_membrane0.65984475
150MP0006054_spinal_hemorrhage0.65963256
151MP0004087_abnormal_muscle_fiber0.65867979
152MP0003221_abnormal_cardiomyocyte_apopto0.65813224
153MP0003786_premature_aging0.65117832
154MP0009765_abnormal_xenobiotic_induced0.64368576
155MP0001845_abnormal_inflammatory_respons0.63863379
156MP0008775_abnormal_heart_ventricle0.62494165
157MP0005310_abnormal_salivary_gland0.61948387
158MP0001661_extended_life_span0.61432714
159MP0003123_paternal_imprinting0.60852606
160MP0003828_pulmonary_edema0.60499249
161MP0003959_abnormal_lean_body0.59410989
162MP0001873_stomach_inflammation0.58343499

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)4.44227680
2Acute necrotizing encephalopathy (HP:0006965)4.21312462
3Hepatocellular necrosis (HP:0001404)4.11704646
4Mitochondrial inheritance (HP:0001427)4.02463683
5Acute encephalopathy (HP:0006846)4.02391552
6Abnormal mitochondria in muscle tissue (HP:0008316)3.94498736
7Increased CSF lactate (HP:0002490)3.75036941
8Hyperglycinuria (HP:0003108)3.73786172
9Dicarboxylic aciduria (HP:0003215)3.53363174
10Abnormality of dicarboxylic acid metabolism (HP:0010995)3.53363174
11Hypoglycemic coma (HP:0001325)3.46858852
12Abnormality of serine family amino acid metabolism (HP:0010894)3.44619050
13Abnormality of glycine metabolism (HP:0010895)3.44619050
14Abnormality of cells of the erythroid lineage (HP:0012130)3.43083290
15Carpal bone hypoplasia (HP:0001498)3.39142086
16Hyperglycinemia (HP:0002154)3.34088329
17Cerebral edema (HP:0002181)3.32580260
18Generalized aminoaciduria (HP:0002909)3.32190016
19Abnormal number of erythroid precursors (HP:0012131)3.29633059
20Cerebral hypomyelination (HP:0006808)3.22974185
21Progressive macrocephaly (HP:0004481)3.20265085
22Lactic acidosis (HP:0003128)3.20133506
23Abnormality of fatty-acid metabolism (HP:0004359)3.15352329
24Elevated erythrocyte sedimentation rate (HP:0003565)3.13513332
25Abnormality of aromatic amino acid family metabolism (HP:0004338)3.12945213
26Multiple enchondromatosis (HP:0005701)3.10171480
27Decreased activity of mitochondrial respiratory chain (HP:0008972)3.07393132
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.07393132
29Lethargy (HP:0001254)2.93688363
30Methylmalonic aciduria (HP:0012120)2.91313848
31Respiratory failure (HP:0002878)2.89723353
32Increased serum pyruvate (HP:0003542)2.89485037
33Abnormality of glycolysis (HP:0004366)2.89485037
34Increased serum lactate (HP:0002151)2.88229620
35Vacuolated lymphocytes (HP:0001922)2.87345818
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.72128288
37CNS demyelination (HP:0007305)2.68610576
38Nausea (HP:0002018)2.68221219
39Ketosis (HP:0001946)2.67023187
40Progressive muscle weakness (HP:0003323)2.64436890
41Exercise intolerance (HP:0003546)2.63626508
42Steatorrhea (HP:0002570)2.63425857
433-Methylglutaconic aciduria (HP:0003535)2.61026342
44Ketoacidosis (HP:0001993)2.59866765
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.59104208
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.56326637
47Abnormality of alanine metabolism (HP:0010916)2.56326637
48Hyperalaninemia (HP:0003348)2.56326637
49Ileus (HP:0002595)2.55485332
50Increased muscle lipid content (HP:0009058)2.54426919
51Abnormality of T cell physiology (HP:0011840)2.50691312
52Chronic obstructive pulmonary disease (HP:0006510)2.50419026
53Obstructive lung disease (HP:0006536)2.50419026
54Hyperammonemia (HP:0001987)2.47778952
55Exertional dyspnea (HP:0002875)2.45503500
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.45491066
57Proximal tubulopathy (HP:0000114)2.45404638
58Panhypogammaglobulinemia (HP:0003139)2.44917717
59Recurrent fungal infections (HP:0002841)2.44036007
60Cerebral palsy (HP:0100021)2.43967609
61Lipid accumulation in hepatocytes (HP:0006561)2.41100959
62Gout (HP:0001997)2.40073901
63Absent rod-and cone-mediated responses on ERG (HP:0007688)2.39637290
64Increased intramyocellular lipid droplets (HP:0012240)2.35442210
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34186491
66Agammaglobulinemia (HP:0004432)2.33782517
67Abnormality of serum amino acid levels (HP:0003112)2.32653830
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.29083014
69Macrocytic anemia (HP:0001972)2.28587824
70Abnormality of the heme biosynthetic pathway (HP:0010472)2.28075584
71Degeneration of anterior horn cells (HP:0002398)2.26262362
72Abnormality of the anterior horn cell (HP:0006802)2.26262362
73Recurrent cutaneous fungal infections (HP:0011370)2.25640769
74Chronic mucocutaneous candidiasis (HP:0002728)2.25640769
75Hypoplasia of the pons (HP:0012110)2.24922484
76Renal Fanconi syndrome (HP:0001994)2.23722104
77Diaphragmatic weakness (HP:0009113)2.23011107
78Emotional lability (HP:0000712)2.22897407
79Hypertensive crisis (HP:0100735)2.22798402
80Recurrent bacterial skin infections (HP:0005406)2.22298834
81Fat malabsorption (HP:0002630)2.21986250
82Prolonged neonatal jaundice (HP:0006579)2.19319967
83Mediastinal lymphadenopathy (HP:0100721)2.18930792
84Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.17039096
85Respiratory difficulties (HP:0002880)2.16932629
86Abnormality of liposaccharide metabolism (HP:0010968)2.14559748
87Abnormality of glycosphingolipid metabolism (HP:0004343)2.14559748
88Abnormality of glycolipid metabolism (HP:0010969)2.14559748
89Stomatitis (HP:0010280)2.14391231
90Ventricular tachycardia (HP:0004756)2.14373335
91Severe visual impairment (HP:0001141)2.14233338
92Pustule (HP:0200039)2.13697004
93Abnormality of the intrinsic pathway (HP:0010989)2.13226818
94Type I transferrin isoform profile (HP:0003642)2.12253354
95Abnormal rod and cone electroretinograms (HP:0008323)2.11853724
96Vomiting (HP:0002013)2.11068211
97Progressive microcephaly (HP:0000253)2.10379675
98Reduced antithrombin III activity (HP:0001976)2.10321010
99Recurrent abscess formation (HP:0002722)2.10319036
100Hypoglycemic seizures (HP:0002173)2.09867832
101Abnormal protein glycosylation (HP:0012346)2.08710241
102Abnormal glycosylation (HP:0012345)2.08710241
103Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08710241
104Abnormal protein N-linked glycosylation (HP:0012347)2.08710241
105Abnormality of the pons (HP:0007361)2.08329102
106Testicular atrophy (HP:0000029)2.08144404
107Myoglobinuria (HP:0002913)2.07327206
108Glycosuria (HP:0003076)2.06497280
109Abnormality of urine glucose concentration (HP:0011016)2.06497280
110Increased IgM level (HP:0003496)2.04734362
111Breast hypoplasia (HP:0003187)2.02554146
112Increased hepatocellular lipid droplets (HP:0006565)2.01636532
113Rhabdomyolysis (HP:0003201)2.01465697
114Opisthotonus (HP:0002179)2.00059411
115Metabolic acidosis (HP:0001942)1.99120259
116Abnormality of subcutaneous fat tissue (HP:0001001)1.98252307
117Increased neuronal autofluorescent lipopigment (HP:0002074)1.97442106
118Optic disc pallor (HP:0000543)1.96631806
119Microretrognathia (HP:0000308)1.96357669
120Congenital, generalized hypertrichosis (HP:0004540)1.95667020
121Petechiae (HP:0000967)1.95234360
122Leukodystrophy (HP:0002415)1.94444201
123Poor head control (HP:0002421)1.94241245
124Bulbar palsy (HP:0001283)1.94182290
125Aplastic anemia (HP:0001915)1.92425862
126Ragged-red muscle fibers (HP:0003200)1.92040382
127CNS hypomyelination (HP:0003429)1.91186208
128Abnormality of renal resorption (HP:0011038)1.90978662
129Birth length less than 3rd percentile (HP:0003561)1.90297116
130Delayed CNS myelination (HP:0002188)1.89917555
131Spastic paraparesis (HP:0002313)1.89883479
132Pancreatic islet-cell hyperplasia (HP:0004510)1.89422269
133Palpitations (HP:0001962)1.88213577
134Unsteady gait (HP:0002317)1.88103615
135Meningitis (HP:0001287)1.87865266
136Muscle fiber splitting (HP:0003555)1.86699087
137Granulocytopenia (HP:0001913)1.86496860
138Absent/shortened dynein arms (HP:0200106)1.84957604
139Dynein arm defect of respiratory motile cilia (HP:0012255)1.84957604
140Mesangial abnormality (HP:0001966)1.84467028
141Myositis (HP:0100614)1.83167286
142Abnormality of T cells (HP:0002843)1.82443042
143Recurrent skin infections (HP:0001581)1.82239835
144Increased serum ferritin (HP:0003281)1.78983265
145Neutropenia (HP:0001875)1.75550784
146Prostate neoplasm (HP:0100787)1.72332258
147IgG deficiency (HP:0004315)1.72084763
148Dysostosis multiplex (HP:0000943)1.71233861
149Muscle fiber atrophy (HP:0100295)1.71061050
150Myopathic facies (HP:0002058)1.69645571
151Hyperthyroidism (HP:0000836)1.68986875
152Abnormality of glycosaminoglycan metabolism (HP:0004371)1.66781136
153Abnormality of mucopolysaccharide metabolism (HP:0011020)1.66781136

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.90482684
2VRK24.79345305
3NME24.52666489
4BUB13.18452027
5MAP4K12.98175250
6EIF2AK32.72885286
7WEE12.67358023
8ERN12.64941509
9STK162.61325641
10EIF2AK12.46779687
11MYLK2.36535134
12SMG12.29306911
13MAPKAPK32.25023495
14TESK22.15827689
15IRAK32.10580778
16PRKD32.03717348
17AKT31.90060152
18TNK21.89431345
19PIM21.89415046
20MAP2K21.88113281
21INSRR1.82511592
22MST41.71422149
23KDR1.71212285
24EPHA21.69972659
25RPS6KB21.68045699
26NUAK11.58299207
27BRSK21.57551069
28GRK61.57168358
29TSSK61.52221613
30PINK11.50315691
31FLT31.47635059
32MAP4K21.43085784
33BRAF1.36910189
34NME11.34757697
35TAOK31.34563466
36STK38L1.31369867
37PRKD21.29724542
38TXK1.28809648
39TYK21.25150184
40TAF11.24116435
41ZAK1.20922118
42ARAF1.17754760
43CSNK1G31.15399186
44SCYL21.11695631
45TESK11.11649326
46TTN1.10629916
47VRK11.10435336
48FRK1.07157674
49ZAP701.05905848
50MAP2K31.05020596
51PIK3CG1.04735209
52LRRK21.04203810
53TRIB31.03855952
54DAPK11.01027209
55ADRBK21.00932014
56RIPK41.00107615
57PDK20.96884817
58CCNB10.95967756
59MAP3K80.95843361
60BTK0.95254811
61ILK0.94136952
62LIMK10.92623881
63PIK3CA0.91000982
64MARK30.89222599
65EEF2K0.87127129
66OBSCN0.85208828
67SYK0.85199993
68TRPM70.83218526
69MAP3K110.81523361
70RPS6KA40.81065633
71CSNK1A1L0.81055101
72MAPK110.79635446
73IRAK20.79413744
74AURKA0.78308714
75TLK10.73822575
76MAP2K60.73114706
77SRPK10.73010119
78KIT0.72947306
79GRK10.72747501
80NEK10.71872606
81IRAK40.71806496
82MAP3K50.70623917
83PRKCQ0.68195177
84TAOK10.67233837
85MAPK120.66999538
86LYN0.65465253
87FES0.65356592
88HIPK20.64553639
89STK100.63613826
90MATK0.63519642
91PRKCI0.63098589
92CDK190.62581802
93CSNK1G10.62561316
94PLK10.60951898
95TBK10.60797233
96TEC0.60525951
97PKN20.60005789
98AURKB0.59955912
99CSNK1G20.59807168
100BRSK10.59399151
101MAPKAPK50.56994335
102GRK50.56662772
103DAPK30.56537991
104PHKG20.55709472
105PHKG10.55709472
106TAOK20.54873934
107BLK0.53502906
108PAK20.52369311
109PASK0.51611455
110MAPKAPK20.50615819
111MAP3K30.47718649
112PAK10.47415608
113PAK40.46856860
114MAP2K10.45855009
115LCK0.43484260
116PDPK10.43417865
117WNK40.43094554
118CSNK2A10.42942604
119SIK20.42931957
120IKBKB0.40880175
121NEK90.40769321
122CSNK2A20.40110244
123PLK40.39977274
124ADRBK10.39752841
125ITK0.39686495
126RPS6KA20.39463404
127LMTK20.38576364
128STK240.37880554
129PTK2B0.37722121
130MAP3K10.37432613
131IKBKE0.36487334
132EIF2AK20.35933991
133ROCK20.35034718
134CDK70.34380573
135TTK0.34337865
136DYRK20.34171174
137STK390.32686779
138PBK0.32358703
139EPHB10.32225652
140ABL20.31321369
141RPS6KA50.31137440
142JAK30.30393694
143PLK30.29497492
144RPS6KA60.27580636
145MUSK0.27097534
146SIK10.26158247
147RPS6KL10.25293355
148RPS6KC10.25293355

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.36283834
2Ribosome_Homo sapiens_hsa030103.29222594
3Protein export_Homo sapiens_hsa030603.09044998
4Primary immunodeficiency_Homo sapiens_hsa053402.68655333
5Oxidative phosphorylation_Homo sapiens_hsa001902.67876296
6RNA polymerase_Homo sapiens_hsa030202.51765352
7Parkinsons disease_Homo sapiens_hsa050122.46498388
8Folate biosynthesis_Homo sapiens_hsa007902.30914781
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13442771
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09356045
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08600127
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.07837654
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03823898
14Allograft rejection_Homo sapiens_hsa053301.96894188
15Graft-versus-host disease_Homo sapiens_hsa053321.85051637
16Autoimmune thyroid disease_Homo sapiens_hsa053201.84732655
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83965563
18Fat digestion and absorption_Homo sapiens_hsa049751.79931497
19Propanoate metabolism_Homo sapiens_hsa006401.79709191
20Asthma_Homo sapiens_hsa053101.77602449
21DNA replication_Homo sapiens_hsa030301.77542714
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73982283
23Caffeine metabolism_Homo sapiens_hsa002321.69349318
24Pyrimidine metabolism_Homo sapiens_hsa002401.66657643
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66476407
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.65359920
27Huntingtons disease_Homo sapiens_hsa050161.59212508
28Type I diabetes mellitus_Homo sapiens_hsa049401.58165530
29Mismatch repair_Homo sapiens_hsa034301.56719419
30Carbon metabolism_Homo sapiens_hsa012001.55854854
31Alzheimers disease_Homo sapiens_hsa050101.50494505
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.48368921
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.48318215
34Biosynthesis of amino acids_Homo sapiens_hsa012301.47341390
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46021128
36Fatty acid degradation_Homo sapiens_hsa000711.45089997
37Glutathione metabolism_Homo sapiens_hsa004801.44938841
38Pancreatic secretion_Homo sapiens_hsa049721.44576267
39Pyruvate metabolism_Homo sapiens_hsa006201.41734272
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.40587313
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.40567399
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38956243
43Sulfur metabolism_Homo sapiens_hsa009201.31938288
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30852006
45Arginine and proline metabolism_Homo sapiens_hsa003301.30433750
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30231669
47Sulfur relay system_Homo sapiens_hsa041221.25305600
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23475576
49Antigen processing and presentation_Homo sapiens_hsa046121.23262582
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19774415
51Peroxisome_Homo sapiens_hsa041461.19595989
52Fructose and mannose metabolism_Homo sapiens_hsa000511.17261633
53Fatty acid elongation_Homo sapiens_hsa000621.17048886
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16663508
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.15403778
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12657906
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12257212
58Selenocompound metabolism_Homo sapiens_hsa004501.11135872
59One carbon pool by folate_Homo sapiens_hsa006701.08212763
60Base excision repair_Homo sapiens_hsa034101.07584186
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06886380
62Pentose phosphate pathway_Homo sapiens_hsa000301.01729132
63Rheumatoid arthritis_Homo sapiens_hsa053231.00708215
64Vitamin B6 metabolism_Homo sapiens_hsa007500.99270521
65Collecting duct acid secretion_Homo sapiens_hsa049660.97026645
66Metabolic pathways_Homo sapiens_hsa011000.96920749
67Regulation of autophagy_Homo sapiens_hsa041400.96133938
68Galactose metabolism_Homo sapiens_hsa000520.95711697
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.95345941
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95049964
71Cardiac muscle contraction_Homo sapiens_hsa042600.94166201
72Fatty acid metabolism_Homo sapiens_hsa012120.93937552
73RNA transport_Homo sapiens_hsa030130.93626800
74Other glycan degradation_Homo sapiens_hsa005110.92789280
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92241404
76Protein digestion and absorption_Homo sapiens_hsa049740.92028869
77Nucleotide excision repair_Homo sapiens_hsa034200.89086288
78Arachidonic acid metabolism_Homo sapiens_hsa005900.88548543
79beta-Alanine metabolism_Homo sapiens_hsa004100.87530961
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86056565
81N-Glycan biosynthesis_Homo sapiens_hsa005100.85666520
82Hematopoietic cell lineage_Homo sapiens_hsa046400.84754464
83Linoleic acid metabolism_Homo sapiens_hsa005910.84188186
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.83980565
85Homologous recombination_Homo sapiens_hsa034400.82296555
86Spliceosome_Homo sapiens_hsa030400.81776949
87Purine metabolism_Homo sapiens_hsa002300.81422450
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80262407
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80156865
90Steroid biosynthesis_Homo sapiens_hsa001000.79654722
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79489454
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79130097
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.78989594
94Chemical carcinogenesis_Homo sapiens_hsa052040.78799231
95Tryptophan metabolism_Homo sapiens_hsa003800.78781555
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77504473
97Staphylococcus aureus infection_Homo sapiens_hsa051500.76881865
98Fanconi anemia pathway_Homo sapiens_hsa034600.74568554
99Leishmaniasis_Homo sapiens_hsa051400.73842293
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70439249
101Viral myocarditis_Homo sapiens_hsa054160.69964881
102Histidine metabolism_Homo sapiens_hsa003400.69126459
103Vitamin digestion and absorption_Homo sapiens_hsa049770.65986786
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65927658
105Glycerolipid metabolism_Homo sapiens_hsa005610.65435414
106Butanoate metabolism_Homo sapiens_hsa006500.64193089
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63070421
108Renin-angiotensin system_Homo sapiens_hsa046140.61979088
109Herpes simplex infection_Homo sapiens_hsa051680.58873029
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58729416
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57599293
112Systemic lupus erythematosus_Homo sapiens_hsa053220.56438434
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54097003
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53486331
115Starch and sucrose metabolism_Homo sapiens_hsa005000.52898205
116Tyrosine metabolism_Homo sapiens_hsa003500.52775304
117Phenylalanine metabolism_Homo sapiens_hsa003600.52221718
118Tuberculosis_Homo sapiens_hsa051520.51743635
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47647481
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.47319815
121Lysosome_Homo sapiens_hsa041420.45552674
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45441616
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44338967
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.41797799
125Epstein-Barr virus infection_Homo sapiens_hsa051690.41733086
126Non-homologous end-joining_Homo sapiens_hsa034500.39129836
127PPAR signaling pathway_Homo sapiens_hsa033200.36544724
128Retinol metabolism_Homo sapiens_hsa008300.34256897
129Nitrogen metabolism_Homo sapiens_hsa009100.32526823
130Arginine biosynthesis_Homo sapiens_hsa002200.32244927
131Measles_Homo sapiens_hsa051620.32122724
132Vibrio cholerae infection_Homo sapiens_hsa051100.32099749
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.31128490
134Ether lipid metabolism_Homo sapiens_hsa005650.30960902
135p53 signaling pathway_Homo sapiens_hsa041150.30850354
136Phagosome_Homo sapiens_hsa041450.30324117

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