NUDT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.45958085
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.35774692
3synaptic vesicle maturation (GO:0016188)5.21865086
4vocalization behavior (GO:0071625)5.20697906
5synaptic vesicle exocytosis (GO:0016079)5.07472357
6regulation of synaptic vesicle exocytosis (GO:2000300)4.94366512
7glutamate secretion (GO:0014047)4.93120103
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.92571332
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.84422277
10locomotory exploration behavior (GO:0035641)4.76519545
11pyrimidine nucleobase catabolic process (GO:0006208)4.68595347
12regulation of glutamate receptor signaling pathway (GO:1900449)4.49425224
13protein localization to synapse (GO:0035418)4.49161478
14neuronal action potential propagation (GO:0019227)4.46066199
15regulation of synaptic vesicle transport (GO:1902803)4.43169876
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.29215382
17neuron cell-cell adhesion (GO:0007158)4.28337691
18neurotransmitter-gated ion channel clustering (GO:0072578)4.26503247
19membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.25774233
20regulation of synapse structural plasticity (GO:0051823)4.12949593
21nucleobase catabolic process (GO:0046113)4.04821484
22neurotransmitter secretion (GO:0007269)4.02898024
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.01899154
24regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.94811055
25regulation of neuronal synaptic plasticity (GO:0048168)3.90782628
26exploration behavior (GO:0035640)3.79567442
27postsynaptic membrane organization (GO:0001941)3.77783996
28regulation of long-term neuronal synaptic plasticity (GO:0048169)3.70590292
29central nervous system projection neuron axonogenesis (GO:0021952)3.69385788
30negative regulation of cytosolic calcium ion concentration (GO:0051481)3.66634036
31activation of protein kinase A activity (GO:0034199)3.62427411
32synaptic transmission, glutamatergic (GO:0035249)3.62113861
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.62090411
34cell migration in hindbrain (GO:0021535)3.60280518
35cell communication by electrical coupling (GO:0010644)3.58910261
36positive regulation of synapse maturation (GO:0090129)3.58666115
37ionotropic glutamate receptor signaling pathway (GO:0035235)3.57021959
38negative regulation of dendrite morphogenesis (GO:0050774)3.54903481
39layer formation in cerebral cortex (GO:0021819)3.54596408
40neuron-neuron synaptic transmission (GO:0007270)3.48724313
41proline transport (GO:0015824)3.43819492
42establishment of mitochondrion localization (GO:0051654)3.42414326
43dendrite morphogenesis (GO:0048813)3.40643062
44startle response (GO:0001964)3.38610628
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.37646578
46presynaptic membrane assembly (GO:0097105)3.34432638
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30536639
48regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.30042527
49cerebellar granule cell differentiation (GO:0021707)3.25416179
50central nervous system neuron axonogenesis (GO:0021955)3.25264982
51membrane depolarization during action potential (GO:0086010)3.24871627
52glutamate receptor signaling pathway (GO:0007215)3.24577928
53dendritic spine morphogenesis (GO:0060997)3.23850544
54limb bud formation (GO:0060174)3.23564646
55negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.23462971
56positive regulation of membrane potential (GO:0045838)3.23122539
57presynaptic membrane organization (GO:0097090)3.19438402
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.19228422
59regulation of neurotransmitter secretion (GO:0046928)3.18225677
60regulation of postsynaptic membrane potential (GO:0060078)3.17402996
61regulation of synaptic plasticity (GO:0048167)3.17013168
62regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.16994898
63auditory behavior (GO:0031223)3.16577846
64regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.14671898
65synaptic vesicle endocytosis (GO:0048488)3.14136829
66regulation of dendritic spine development (GO:0060998)3.12911309
67neuron recognition (GO:0008038)3.11769377
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.11186042
69positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.11072237
70neurotransmitter transport (GO:0006836)3.10074271
71regulation of membrane repolarization (GO:0060306)3.08622019
72cerebral cortex radially oriented cell migration (GO:0021799)3.07204132
73regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.06467457
74long-term synaptic potentiation (GO:0060291)3.05190047
75G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.05026292
76positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02519905
77mechanosensory behavior (GO:0007638)3.02290595
78gamma-aminobutyric acid transport (GO:0015812)3.01889720
79innervation (GO:0060384)3.01743232
80cerebellar Purkinje cell differentiation (GO:0021702)3.01592912
81regulation of voltage-gated calcium channel activity (GO:1901385)3.01558700
82positive regulation of neurotransmitter secretion (GO:0001956)3.01193263
83negative regulation of dendrite development (GO:2000171)3.01165036
84cellular potassium ion homeostasis (GO:0030007)2.97918489
85regulation of cell communication by electrical coupling (GO:0010649)2.97583457
86long-term memory (GO:0007616)2.94764965
87positive regulation of neurotransmitter transport (GO:0051590)2.94753468
88axonal fasciculation (GO:0007413)2.94441472
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.93811773
90neuromuscular process controlling balance (GO:0050885)2.93294464
91membrane depolarization (GO:0051899)2.92729090
92regulation of synaptic transmission, glutamatergic (GO:0051966)2.92672678
93regulation of neurotransmitter transport (GO:0051588)2.92190152
94regulation of dendritic spine morphogenesis (GO:0061001)2.90981505
95positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90330242
96glial cell proliferation (GO:0014009)2.90119186
97transmission of nerve impulse (GO:0019226)2.89331078
98regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.89153789
99establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.89008975
100mitochondrion transport along microtubule (GO:0047497)2.89008975
101regulation of synapse maturation (GO:0090128)2.86951563
102positive regulation of potassium ion transmembrane transport (GO:1901381)2.85736858
103negative regulation of microtubule polymerization (GO:0031115)2.85511616
104response to auditory stimulus (GO:0010996)2.85170873
105positive regulation of synaptic transmission, GABAergic (GO:0032230)2.84230659
106sodium ion export (GO:0071436)2.84175659
107regulation of neurotransmitter levels (GO:0001505)2.83880447
108glycosphingolipid biosynthetic process (GO:0006688)2.83481706
109positive regulation of dendritic spine development (GO:0060999)2.81318838
110synapse assembly (GO:0007416)2.81293099
111neuronal action potential (GO:0019228)2.77975728
112regulation of calcium ion transmembrane transporter activity (GO:1901019)2.77618260
113regulation of calcium ion transmembrane transport (GO:1903169)2.77618260
114cell communication involved in cardiac conduction (GO:0086065)2.76152318
115neuromuscular synaptic transmission (GO:0007274)2.76014153
116C4-dicarboxylate transport (GO:0015740)2.75845716
117regulation of ion transmembrane transporter activity (GO:0032412)2.74943396
118regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.74722680
119regulation of vesicle fusion (GO:0031338)2.73411789
120gamma-aminobutyric acid signaling pathway (GO:0007214)2.72530468
121detection of calcium ion (GO:0005513)2.72520546
122learning (GO:0007612)2.72346319
123regulation of respiratory system process (GO:0044065)2.71490331
124positive regulation of synapse assembly (GO:0051965)2.70409372
125regulation of timing of cell differentiation (GO:0048505)2.69576754
126response to pheromone (GO:0019236)2.69432587
127retinal ganglion cell axon guidance (GO:0031290)2.66766503
128positive regulation of dendritic spine morphogenesis (GO:0061003)2.65463818
129axon ensheathment in central nervous system (GO:0032291)2.64015251
130central nervous system myelination (GO:0022010)2.64015251
131righting reflex (GO:0060013)2.62457072
132behavioral fear response (GO:0001662)2.59844772
133behavioral defense response (GO:0002209)2.59844772
134positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.59668776
135spinal cord development (GO:0021510)2.56745618
136positive regulation of amino acid transport (GO:0051957)2.52963090
137neuronal ion channel clustering (GO:0045161)2.52719715
138membrane hyperpolarization (GO:0060081)2.51578605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.81876196
2GBX2_23144817_ChIP-Seq_PC3_Human3.38193738
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20282115
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11226287
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04795240
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.87157851
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82896379
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82896379
9REST_21632747_ChIP-Seq_MESCs_Mouse2.81645217
10IGF1R_20145208_ChIP-Seq_DFB_Human2.76240289
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69699837
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.63579849
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59804593
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52637043
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52034161
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49076473
17* REST_18959480_ChIP-ChIP_MESCs_Mouse2.45950228
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43615577
19* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41099050
20DROSHA_22980978_ChIP-Seq_HELA_Human2.38491693
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.35470168
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30261135
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.29554634
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27773148
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.27188906
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.25974834
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.18860971
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11618852
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11292015
30VDR_22108803_ChIP-Seq_LS180_Human2.06604709
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.05118076
32FUS_26573619_Chip-Seq_HEK293_Human1.99865495
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92773697
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92401973
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.88645901
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75305216
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71102647
38AR_21572438_ChIP-Seq_LNCaP_Human1.68262560
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66145030
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65884550
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61677850
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61677850
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56375056
44EWS_26573619_Chip-Seq_HEK293_Human1.55396909
45SMAD4_21799915_ChIP-Seq_A2780_Human1.51749497
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46779633
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.46224534
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45284573
49TAF15_26573619_Chip-Seq_HEK293_Human1.45017509
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44536147
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44401564
52ER_23166858_ChIP-Seq_MCF-7_Human1.43319435
53RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41400812
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39327409
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38796784
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37310294
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.37038225
58BCAT_22108803_ChIP-Seq_LS180_Human1.35277222
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34992044
60ZNF274_21170338_ChIP-Seq_K562_Hela1.34532536
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34226333
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34079215
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33810183
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32888961
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32226210
66* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30601433
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30350273
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29500518
69CBP_20019798_ChIP-Seq_JUKART_Human1.29382364
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29382364
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.28281610
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.26268886
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26034579
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25711727
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24545451
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23549259
77* RUNX2_22187159_ChIP-Seq_PCA_Human1.20834933
78KDM2B_26808549_Chip-Seq_K562_Human1.20766715
79AR_19668381_ChIP-Seq_PC3_Human1.19830846
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19806377
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.19800084
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19381745
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19289919
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.17619597
85P300_19829295_ChIP-Seq_ESCs_Human1.16490832
86* AR_25329375_ChIP-Seq_VCAP_Human1.16119773
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15827679
88SOX9_26525672_Chip-Seq_HEART_Mouse1.15699071
89* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15674834
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15353217
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15045299
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.14126733
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13783310
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13058607
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.12721560
96RNF2_27304074_Chip-Seq_NSC_Mouse1.11720607
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10568420
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.09957709
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09571102
100YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08929282
101AHR_22903824_ChIP-Seq_MCF-7_Human1.08147549
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08031372
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07790926
104P53_22387025_ChIP-Seq_ESCs_Mouse1.07405570
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07347727
106STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06905419
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.06582697
108* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06400470
109ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05911608
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05725163
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05111837
112STAT3_23295773_ChIP-Seq_U87_Human1.04832265
113TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04484668
114SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03064512
115KDM2B_26808549_Chip-Seq_REH_Human1.02908630
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.02890115
117PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02701460
118TCF4_22108803_ChIP-Seq_LS180_Human1.02445396
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01059926
120* SMAD3_21741376_ChIP-Seq_ESCs_Human0.98700097
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98488269
122TCF4_23295773_ChIP-Seq_U87_Human0.96925431
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96052505
124* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95025533
125TET1_21490601_ChIP-Seq_MESCs_Mouse0.94935938
126CTCF_27219007_Chip-Seq_Bcells_Human0.91557097
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91205611
128RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90376583
129* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89611467
130EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89533142
131* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89220750
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.88136016
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.87728896
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.86762366
135ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84943028
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84784966
137TP53_20018659_ChIP-ChIP_R1E_Mouse0.84124622
138GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84010294
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83454521
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83424884
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82500499
142ESR1_20079471_ChIP-ChIP_T-47D_Human0.81228036

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.66106275
2MP0003880_abnormal_central_pattern3.98841815
3MP0004270_analgesia3.77196587
4MP0003635_abnormal_synaptic_transmissio3.69436949
5MP0000569_abnormal_digit_pigmentation3.16254968
6MP0002063_abnormal_learning/memory/cond3.07194564
7MP0009745_abnormal_behavioral_response3.00980759
8MP0001968_abnormal_touch/_nociception2.89269379
9MP0009046_muscle_twitch2.89062470
10MP0002064_seizures2.79073707
11MP0002735_abnormal_chemical_nociception2.64047501
12MP0002734_abnormal_mechanical_nocicepti2.63633217
13MP0002572_abnormal_emotion/affect_behav2.48186782
14MP0002272_abnormal_nervous_system2.42722225
15MP0002736_abnormal_nociception_after2.40293347
16MP0000751_myopathy2.30453681
17MP0004858_abnormal_nervous_system2.24924395
18MP0001486_abnormal_startle_reflex2.15916721
19MP0002837_dystrophic_cardiac_calcinosis2.13270986
20MP0009780_abnormal_chondrocyte_physiolo2.12540758
21MP0005423_abnormal_somatic_nervous2.07449504
22MP0002822_catalepsy2.02940972
23MP0002733_abnormal_thermal_nociception1.94808923
24MP0008569_lethality_at_weaning1.93382212
25MP0002067_abnormal_sensory_capabilities1.92690751
26MP0001970_abnormal_pain_threshold1.90477916
27MP0004811_abnormal_neuron_physiology1.86407045
28MP0002184_abnormal_innervation1.80859986
29MP0003646_muscle_fatigue1.80626905
30MP0001440_abnormal_grooming_behavior1.80368574
31MP0000778_abnormal_nervous_system1.79168886
32MP0002102_abnormal_ear_morphology1.74732511
33MP0002638_abnormal_pupillary_reflex1.72214283
34MP0005646_abnormal_pituitary_gland1.71074051
35MP0008877_abnormal_DNA_methylation1.68876764
36MP0004924_abnormal_behavior1.67387174
37MP0005386_behavior/neurological_phenoty1.67387174
38MP0005551_abnormal_eye_electrophysiolog1.65623146
39MP0006276_abnormal_autonomic_nervous1.64317249
40MP0003787_abnormal_imprinting1.61780910
41MP0001501_abnormal_sleep_pattern1.61052327
42MP0004215_abnormal_myocardial_fiber1.60698291
43MP0002909_abnormal_adrenal_gland1.59975396
44MP0001984_abnormal_olfaction1.59820401
45MP0002557_abnormal_social/conspecific_i1.59503690
46MP0000955_abnormal_spinal_cord1.56011060
47MP0003121_genomic_imprinting1.53408946
48MP0000372_irregular_coat_pigmentation1.48643305
49MP0003879_abnormal_hair_cell1.47821362
50MP0004885_abnormal_endolymph1.40313196
51MP0002882_abnormal_neuron_morphology1.39460334
52MP0004084_abnormal_cardiac_muscle1.35874476
53MP0004145_abnormal_muscle_electrophysio1.33241983
54MP0002066_abnormal_motor_capabilities/c1.32279129
55MP0003122_maternal_imprinting1.32019048
56MP0003329_amyloid_beta_deposits1.31523392
57MP0005253_abnormal_eye_physiology1.30149045
58MP0004085_abnormal_heartbeat1.28618492
59MP0004036_abnormal_muscle_relaxation1.24891047
60MP0006072_abnormal_retinal_apoptosis1.18869349
61MP0001529_abnormal_vocalization1.18729544
62MP0003137_abnormal_impulse_conducting1.18582103
63MP0005645_abnormal_hypothalamus_physiol1.17587837
64MP0005174_abnormal_tail_pigmentation1.16341238
65MP0004142_abnormal_muscle_tone1.15850789
66MP0004484_altered_response_of1.15129744
67MP0003633_abnormal_nervous_system1.13669273
68MP0000015_abnormal_ear_pigmentation1.13255231
69MP0000749_muscle_degeneration1.13203590
70MP0005394_taste/olfaction_phenotype1.11750202
71MP0005499_abnormal_olfactory_system1.11750202
72MP0001905_abnormal_dopamine_level1.11230070
73MP0004233_abnormal_muscle_weight1.07286104
74MP0002152_abnormal_brain_morphology1.03727860
75MP0001188_hyperpigmentation1.02502845
76MP0002972_abnormal_cardiac_muscle1.00851008
77MP0001502_abnormal_circadian_rhythm1.00450786
78MP0002938_white_spotting0.98048196
79MP0005620_abnormal_muscle_contractility0.97129867
80MP0003136_yellow_coat_color0.96423358
81MP0003631_nervous_system_phenotype0.96367044
82MP0008872_abnormal_physiological_respon0.95451664
83MP0001986_abnormal_taste_sensitivity0.94662943
84MP0005623_abnormal_meninges_morphology0.93131143
85MP0000516_abnormal_urinary_system0.91172127
86MP0005367_renal/urinary_system_phenotyp0.91172127
87MP0002653_abnormal_ependyma_morphology0.85847580
88MP0005187_abnormal_penis_morphology0.85640392
89MP0006292_abnormal_olfactory_placode0.85379752
90MP0002229_neurodegeneration0.84399483
91MP0003634_abnormal_glial_cell0.83905829
92MP0004130_abnormal_muscle_cell0.83776752
93MP0002751_abnormal_autonomic_nervous0.81458150
94MP0001485_abnormal_pinna_reflex0.81345224
95MP0003890_abnormal_embryonic-extraembry0.80934450
96MP0000013_abnormal_adipose_tissue0.80862101
97MP0004133_heterotaxia0.80467291
98MP0002234_abnormal_pharynx_morphology0.80239311
99MP0002069_abnormal_eating/drinking_beha0.79112200
100MP0002095_abnormal_skin_pigmentation0.79021878
101MP0000631_abnormal_neuroendocrine_gland0.76273986
102MP0004087_abnormal_muscle_fiber0.76182431
103MP0001963_abnormal_hearing_physiology0.75689125
104MP0004742_abnormal_vestibular_system0.75218743
105MP0002090_abnormal_vision0.74773109
106MP0003283_abnormal_digestive_organ0.74275935
107MP0002106_abnormal_muscle_physiology0.73812349
108MP0005248_abnormal_Harderian_gland0.72566693
109MP0000747_muscle_weakness0.72501498
110MP0002752_abnormal_somatic_nervous0.72274375
111MP0003861_abnormal_nervous_system0.70093787
112MP0001177_atelectasis0.69501114
113MP0000759_abnormal_skeletal_muscle0.69435261
114MP0005171_absent_coat_pigmentation0.69216516
115MP0008874_decreased_physiological_sensi0.66770807
116MP0005330_cardiomyopathy0.66534089
117MP0005195_abnormal_posterior_eye0.66418959
118MP0000026_abnormal_inner_ear0.64761443
119MP0001943_abnormal_respiration0.64666012
120MP0005369_muscle_phenotype0.64255105
121MP0001348_abnormal_lacrimal_gland0.64024801
122MP0003195_calcinosis0.63694796
123MP0004043_abnormal_pH_regulation0.63686702
124MP0004147_increased_porphyrin_level0.63201148
125MP0003183_abnormal_peptide_metabolism0.62488881
126MP0008789_abnormal_olfactory_epithelium0.61739866
127MP0006138_congestive_heart_failure0.61503170
128MP0008775_abnormal_heart_ventricle0.60961487
129MP0005535_abnormal_body_temperature0.60631053
130MP0001299_abnormal_eye_distance/0.60455163

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.57756774
2Myokymia (HP:0002411)6.01386872
3Focal seizures (HP:0007359)4.59639481
4Visual hallucinations (HP:0002367)4.40737962
5Atonic seizures (HP:0010819)4.39846813
6Epileptic encephalopathy (HP:0200134)4.36094972
7Febrile seizures (HP:0002373)4.27165748
8Pheochromocytoma (HP:0002666)3.69076554
9Progressive cerebellar ataxia (HP:0002073)3.41011854
10Action tremor (HP:0002345)3.39606989
11Ankle clonus (HP:0011448)3.38167357
12Absence seizures (HP:0002121)3.35683549
13Neuroendocrine neoplasm (HP:0100634)3.28864622
14Hyperventilation (HP:0002883)3.06313223
15Generalized tonic-clonic seizures (HP:0002069)3.06230803
16Dialeptic seizures (HP:0011146)3.03252975
17Broad-based gait (HP:0002136)2.96503159
18Impaired vibration sensation in the lower limbs (HP:0002166)2.94625067
19Absent speech (HP:0001344)2.93107964
20Depression (HP:0000716)2.92105625
21Poor eye contact (HP:0000817)2.91716364
22Abnormality of the labia minora (HP:0012880)2.89724913
23Sudden death (HP:0001699)2.87419715
24Ventricular fibrillation (HP:0001663)2.78712765
25Gaze-evoked nystagmus (HP:0000640)2.78137660
26Bundle branch block (HP:0011710)2.78095298
27Amblyopia (HP:0000646)2.76747333
28Intestinal atresia (HP:0011100)2.69991435
29Urinary urgency (HP:0000012)2.69321183
30Termporal pattern (HP:0011008)2.69271850
31Insidious onset (HP:0003587)2.69271850
32Anxiety (HP:0000739)2.66805490
33Protruding tongue (HP:0010808)2.64841492
34Urinary bladder sphincter dysfunction (HP:0002839)2.62034124
35Neoplasm of the peripheral nervous system (HP:0100007)2.60374716
36Abnormal social behavior (HP:0012433)2.59447811
37Impaired social interactions (HP:0000735)2.59447811
38Hypothermia (HP:0002045)2.59357556
39Truncal ataxia (HP:0002078)2.58234838
40Supranuclear gaze palsy (HP:0000605)2.57164366
41Abnormality of the lower motor neuron (HP:0002366)2.55474312
42Fetal akinesia sequence (HP:0001989)2.51836474
43Dysmetric saccades (HP:0000641)2.51760066
44Exercise-induced myalgia (HP:0003738)2.51022729
45Dysdiadochokinesis (HP:0002075)2.47611159
46Myotonia (HP:0002486)2.45104513
47Abnormal eating behavior (HP:0100738)2.44254020
48Atrial fibrillation (HP:0005110)2.41350483
49Inability to walk (HP:0002540)2.41199806
50Failure to thrive in infancy (HP:0001531)2.39341049
51Primary atrial arrhythmia (HP:0001692)2.36941200
52Polyphagia (HP:0002591)2.36541235
53Gait imbalance (HP:0002141)2.35208318
54Exotropia (HP:0000577)2.34793520
55Sleep apnea (HP:0010535)2.32511155
56Prolonged QT interval (HP:0001657)2.27694919
57Hip dysplasia (HP:0001385)2.26925650
58Limb dystonia (HP:0002451)2.26353925
59Supraventricular tachycardia (HP:0004755)2.25898733
60Abnormality of the corticospinal tract (HP:0002492)2.23524437
61Nephronophthisis (HP:0000090)2.22997619
62Supraventricular arrhythmia (HP:0005115)2.19807361
63Medial flaring of the eyebrow (HP:0010747)2.19708783
64Lower limb muscle weakness (HP:0007340)2.19245895
65Postural instability (HP:0002172)2.18699424
66Abnormal EKG (HP:0003115)2.18165926
67True hermaphroditism (HP:0010459)2.15973978
68Genetic anticipation (HP:0003743)2.14978502
69Pancreatic fibrosis (HP:0100732)2.14638496
70Megalencephaly (HP:0001355)2.14622736
71Abnormality of the astrocytes (HP:0100707)2.12045252
72Astrocytoma (HP:0009592)2.12045252
73Epileptiform EEG discharges (HP:0011182)2.11900343
74Exercise-induced muscle cramps (HP:0003710)2.11286509
75Resting tremor (HP:0002322)2.10871794
76Dysmetria (HP:0001310)2.10379068
77Spastic gait (HP:0002064)2.09927552
78Lissencephaly (HP:0001339)2.09506510
79Calf muscle hypertrophy (HP:0008981)2.09098422
80Lower limb amyotrophy (HP:0007210)2.08687921
81Pancreatic cysts (HP:0001737)2.08514483
82Molar tooth sign on MRI (HP:0002419)2.08253371
83Abnormality of midbrain morphology (HP:0002418)2.08253371
84Hypoventilation (HP:0002791)2.07837772
85Abnormality of the calf musculature (HP:0001430)2.07355431
86Annular pancreas (HP:0001734)2.05118088
87Hepatoblastoma (HP:0002884)2.05000882
88Progressive inability to walk (HP:0002505)2.04512477
89Torticollis (HP:0000473)2.03620946
90Blue irides (HP:0000635)2.03024683
91Impaired smooth pursuit (HP:0007772)2.02225801
92Aqueductal stenosis (HP:0002410)2.01787641
93Volvulus (HP:0002580)2.01627405
94Bradykinesia (HP:0002067)2.01376423
95Papilledema (HP:0001085)2.00686667
96Spinal muscular atrophy (HP:0007269)2.00670025
97Syncope (HP:0001279)1.98495051
98EEG with generalized epileptiform discharges (HP:0011198)1.97622051
99Muscle hypertrophy of the lower extremities (HP:0008968)1.97197811
100Pachygyria (HP:0001302)1.96309923
101Impaired pain sensation (HP:0007328)1.96214329
102Abnormality of pain sensation (HP:0010832)1.96214329
103Generalized hypotonia (HP:0001290)1.94569077
104Hypoplasia of the brainstem (HP:0002365)1.94483760
105Aplasia/Hypoplasia of the brainstem (HP:0007362)1.94483760
106Focal dystonia (HP:0004373)1.94235668
107Hypsarrhythmia (HP:0002521)1.94040653
108Excessive salivation (HP:0003781)1.92088838
109Drooling (HP:0002307)1.92088838
110Pointed chin (HP:0000307)1.90633311
111Spinal canal stenosis (HP:0003416)1.90597331
112Impaired vibratory sensation (HP:0002495)1.90273342
113Bradycardia (HP:0001662)1.87964115
114Abnormality of the renal medulla (HP:0100957)1.87011170
115Renal cortical cysts (HP:0000803)1.86960951
116Scanning speech (HP:0002168)1.86497513
117Retinal dysplasia (HP:0007973)1.86268469
118Status epilepticus (HP:0002133)1.85986572
119Hemiparesis (HP:0001269)1.85943841
120Abnormal hair whorl (HP:0010721)1.83271597
121Incomplete penetrance (HP:0003829)1.83234536
122Lower limb asymmetry (HP:0100559)1.82862559
123Genital tract atresia (HP:0001827)1.81898950
124Congenital primary aphakia (HP:0007707)1.81282916
125Stereotypic behavior (HP:0000733)1.81164239
126Degeneration of the lateral corticospinal tracts (HP:0002314)1.80442791
127Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80442791
128Nephrogenic diabetes insipidus (HP:0009806)1.80401730
129Hamartoma of the eye (HP:0010568)1.79947009
130Diplopia (HP:0000651)1.79608896
131Abnormality of binocular vision (HP:0011514)1.79608896
132Congenital stationary night blindness (HP:0007642)1.78114132
133Agitation (HP:0000713)1.77307720
134Heart block (HP:0012722)1.76823528
135Hypercortisolism (HP:0001578)1.76585564
136Specific learning disability (HP:0001328)1.76265696
137Abnormality of the renal cortex (HP:0011035)1.76037801
138Neoplasm of the adrenal cortex (HP:0100641)1.75880393
139Chronic hepatic failure (HP:0100626)1.75069911
140Amyotrophic lateral sclerosis (HP:0007354)1.74843933
141Mutism (HP:0002300)1.73792331
142Muscular hypotonia of the trunk (HP:0008936)1.73498001
143Spastic tetraplegia (HP:0002510)1.73142259
144Ependymoma (HP:0002888)1.72582945
145Akinesia (HP:0002304)1.72546796
146Widely spaced teeth (HP:0000687)1.70849002
147Vaginal atresia (HP:0000148)1.70729735
148Papillary thyroid carcinoma (HP:0002895)1.70196944
149Tubulointerstitial nephritis (HP:0001970)1.70156898
150Generalized hypopigmentation of hair (HP:0011358)1.66850365
151Tented upper lip vermilion (HP:0010804)1.66535028
152Long clavicles (HP:0000890)1.66371712
153Generalized myoclonic seizures (HP:0002123)1.66224612
154Abnormality of salivation (HP:0100755)1.65745223
155Ketoacidosis (HP:0001993)1.64019872
156Type II lissencephaly (HP:0007260)1.63703567

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.84735553
2CASK3.65355201
3NTRK33.42955883
4WNK33.22159287
5MARK13.11850971
6EPHA42.95360645
7MAP3K42.90451892
8MINK12.89875991
9MAP2K72.84732390
10MAP3K92.60602671
11DAPK22.41393934
12PRPF4B2.38153029
13MAP3K122.23806620
14CDK192.08621406
15PRKD31.93892307
16PAK61.86945236
17MAP4K21.85651395
18PHKG21.80727239
19PHKG11.80727239
20FGFR21.78596830
21DAPK11.77600317
22CAMKK11.76352396
23PLK21.74607890
24MAP2K41.71714008
25BMPR1B1.61168360
26NTRK21.60285360
27MAPK131.60202510
28KSR11.55297801
29TRIM281.54068571
30PNCK1.52974156
31NEK11.50739272
32SGK4941.46652270
33SGK2231.46652270
34LMTK21.43912894
35DYRK21.43873849
36KSR21.43872613
37SGK21.43779831
38SIK31.42311367
39CDK51.37321053
40MKNK21.31050310
41CSNK1G21.24991554
42UHMK11.24780476
43CCNB11.24340952
44PDK31.23351882
45PDK41.23351882
46PINK11.21832445
47NTRK11.19293245
48PRKCG1.19048111
49SGK31.16295621
50OBSCN1.15305180
51BCR1.14974235
52GRK51.14125888
53AKT31.12226178
54CAMKK21.06204302
55TYRO31.05261288
56PKN10.92643741
57PRKCH0.91980422
58CDK180.90829752
59STK380.89166237
60CSNK1G30.88336565
61NUAK10.88128428
62ARAF0.87914221
63ERBB30.86867595
64CAMK2A0.85650246
65CSNK1G10.85421959
66EPHA30.84260287
67RPS6KA20.84207430
68CAMK1G0.83987980
69TRIB30.81468859
70CDK150.81171311
71SIK20.80273110
72CDK140.78906998
73RET0.77996642
74PLK30.76416383
75INSRR0.74027917
76LATS20.73778566
77CSNK1A1L0.72762973
78CDK11A0.70839208
79LIMK10.70779725
80MAP3K20.70181753
81PTK2B0.69687621
82STK390.69137919
83DAPK30.68769526
84ACVR1B0.68638139
85FER0.68450351
86TNK20.67500563
87YES10.66539525
88MYLK0.65462062
89TAOK10.65053949
90PAK30.63431927
91WNK10.63038303
92OXSR10.61597324
93STK110.61565028
94BRSK10.60601975
95ADRBK20.60120875
96PKN20.60101235
97CAMK10.58815745
98RIPK40.58646811
99SGK10.58377957
100FES0.58174828
101MKNK10.58016606
102TNIK0.57792067
103CDC42BPA0.57609083
104PRKCE0.57062518
105CAMK40.56217644
106PDK10.55098089
107CAMK2B0.54254315
108WNK40.51612297
109CDK30.51219614
110CSNK1D0.51124955
111ALK0.50824259
112ROCK20.50670837
113ROCK10.50221856
114PRKAA10.48984717
115PDPK10.48820703
116GRK10.48287772
117CLK10.47572745
118MAP2K10.46314169
119CAMK2D0.45347382
120DYRK1A0.44839724
121DMPK0.44812263
122PRKG10.44741065
123CAMK1D0.43537341
124PRKACA0.42969682
125RPS6KA30.42941600
126PDK20.42056127
127CSNK1A10.41342066
128MAPK100.40292815
129BMPR20.39380631
130MUSK0.39353134
131NME10.39178951
132TSSK60.39006376
133CSNK1E0.38625652
134RPS6KB10.38595335
135PRKCZ0.37657343
136MAPK120.37148180
137EIF2AK30.36142020
138BRAF0.36041436
139CAMK2G0.36021983
140MARK20.35756198
141ADRBK10.34918748
142MAP3K70.34597541
143PRKDC0.34539237
144GSK3B0.33276594
145PRKACB0.30791782
146MAPK80.30555411
147WEE10.30400696

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.39553812
2Nicotine addiction_Homo sapiens_hsa050332.89172825
3Olfactory transduction_Homo sapiens_hsa047402.81338226
4Circadian entrainment_Homo sapiens_hsa047132.51204771
5Long-term potentiation_Homo sapiens_hsa047202.41888291
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.27110054
7GABAergic synapse_Homo sapiens_hsa047272.26360791
8Morphine addiction_Homo sapiens_hsa050322.20132110
9Glutamatergic synapse_Homo sapiens_hsa047242.17574684
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16969067
11Amphetamine addiction_Homo sapiens_hsa050312.14870507
12Dopaminergic synapse_Homo sapiens_hsa047282.10442859
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06208077
14Butanoate metabolism_Homo sapiens_hsa006501.91748311
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.91230135
16Insulin secretion_Homo sapiens_hsa049111.90852529
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.89669513
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79103211
19Salivary secretion_Homo sapiens_hsa049701.78610676
20Cholinergic synapse_Homo sapiens_hsa047251.78018182
21Gastric acid secretion_Homo sapiens_hsa049711.77568717
22Collecting duct acid secretion_Homo sapiens_hsa049661.72012245
23Taste transduction_Homo sapiens_hsa047421.67538123
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59709256
25Oxytocin signaling pathway_Homo sapiens_hsa049211.58407399
26Cardiac muscle contraction_Homo sapiens_hsa042601.57549032
27Renin secretion_Homo sapiens_hsa049241.51661723
28Propanoate metabolism_Homo sapiens_hsa006401.50063702
29Long-term depression_Homo sapiens_hsa047301.44306781
30Serotonergic synapse_Homo sapiens_hsa047261.43213167
31Calcium signaling pathway_Homo sapiens_hsa040201.43147597
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.42551298
33Gap junction_Homo sapiens_hsa045401.41204794
34Cocaine addiction_Homo sapiens_hsa050301.38881933
35GnRH signaling pathway_Homo sapiens_hsa049121.27574957
36Dilated cardiomyopathy_Homo sapiens_hsa054141.27442297
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20606739
38Vibrio cholerae infection_Homo sapiens_hsa051101.20164870
39Glioma_Homo sapiens_hsa052141.18672675
40cAMP signaling pathway_Homo sapiens_hsa040241.16861770
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14640841
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12677407
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11144827
44ErbB signaling pathway_Homo sapiens_hsa040121.10096690
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09939842
46Axon guidance_Homo sapiens_hsa043601.09840099
47Type II diabetes mellitus_Homo sapiens_hsa049301.06478861
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06110813
49Estrogen signaling pathway_Homo sapiens_hsa049151.05925831
50Regulation of autophagy_Homo sapiens_hsa041401.04626508
51Melanogenesis_Homo sapiens_hsa049161.00257565
52Protein export_Homo sapiens_hsa030600.97631549
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92578818
54Oocyte meiosis_Homo sapiens_hsa041140.90491035
55Parkinsons disease_Homo sapiens_hsa050120.90200652
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89817943
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.89572726
58Nitrogen metabolism_Homo sapiens_hsa009100.87129628
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86955900
60Alzheimers disease_Homo sapiens_hsa050100.86657128
61Oxidative phosphorylation_Homo sapiens_hsa001900.85880003
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85721237
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84379159
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83533676
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82873631
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81858782
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.81226438
68Endometrial cancer_Homo sapiens_hsa052130.79796029
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79407022
70Steroid biosynthesis_Homo sapiens_hsa001000.79235629
71Glucagon signaling pathway_Homo sapiens_hsa049220.77422929
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77338123
73MAPK signaling pathway_Homo sapiens_hsa040100.75983705
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74313526
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74225224
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73943629
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73792538
78Insulin signaling pathway_Homo sapiens_hsa049100.73699762
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72785529
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72483653
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71562804
82Tryptophan metabolism_Homo sapiens_hsa003800.69732579
83Fatty acid metabolism_Homo sapiens_hsa012120.69639864
84Ether lipid metabolism_Homo sapiens_hsa005650.67951702
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.67336077
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66670277
87beta-Alanine metabolism_Homo sapiens_hsa004100.65158237
88Non-homologous end-joining_Homo sapiens_hsa034500.63409351
89Dorso-ventral axis formation_Homo sapiens_hsa043200.63212607
90VEGF signaling pathway_Homo sapiens_hsa043700.62889521
91mTOR signaling pathway_Homo sapiens_hsa041500.62698449
92Fatty acid elongation_Homo sapiens_hsa000620.61380812
93Phototransduction_Homo sapiens_hsa047440.58070030
94Non-small cell lung cancer_Homo sapiens_hsa052230.57742974
95Ras signaling pathway_Homo sapiens_hsa040140.57701002
96Thyroid hormone synthesis_Homo sapiens_hsa049180.56069492
97Alcoholism_Homo sapiens_hsa050340.55735087
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55174609
99Pancreatic secretion_Homo sapiens_hsa049720.54730951
100Huntingtons disease_Homo sapiens_hsa050160.54450374
101Rap1 signaling pathway_Homo sapiens_hsa040150.54368081
102Endocytosis_Homo sapiens_hsa041440.53503975
103Basal transcription factors_Homo sapiens_hsa030220.52912748
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52720852
105Choline metabolism in cancer_Homo sapiens_hsa052310.52639082
106Vitamin B6 metabolism_Homo sapiens_hsa007500.50585868
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50126784
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49348440
109Colorectal cancer_Homo sapiens_hsa052100.49177577
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48157993
111Circadian rhythm_Homo sapiens_hsa047100.47878696
112Inositol phosphate metabolism_Homo sapiens_hsa005620.47177565
113Renal cell carcinoma_Homo sapiens_hsa052110.46567502
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.45522985
115ABC transporters_Homo sapiens_hsa020100.45301739
116Wnt signaling pathway_Homo sapiens_hsa043100.45275824
117RNA degradation_Homo sapiens_hsa030180.44601122
118Melanoma_Homo sapiens_hsa052180.43349858
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.43004243
120Prolactin signaling pathway_Homo sapiens_hsa049170.42963503
121Type I diabetes mellitus_Homo sapiens_hsa049400.40933393
122AMPK signaling pathway_Homo sapiens_hsa041520.40690022
123Peroxisome_Homo sapiens_hsa041460.40590991
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40036258
125Ovarian steroidogenesis_Homo sapiens_hsa049130.39935943
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38951388
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37838361
128Hedgehog signaling pathway_Homo sapiens_hsa043400.36110762
129Phagosome_Homo sapiens_hsa041450.34583481
130Tight junction_Homo sapiens_hsa045300.32282188

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