NUDT4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)9.82000035
2protoporphyrinogen IX biosynthetic process (GO:0006782)7.11751071
3hemoglobin metabolic process (GO:0020027)7.09218691
4oxygen transport (GO:0015671)7.04784567
5porphyrin-containing compound biosynthetic process (GO:0006779)6.98021287
6gas transport (GO:0015669)6.46143034
7erythrocyte maturation (GO:0043249)6.28546021
8erythrocyte development (GO:0048821)6.26832761
9regulation of RNA export from nucleus (GO:0046831)6.04981288
10tetrapyrrole biosynthetic process (GO:0033014)6.01851938
11porphyrin-containing compound metabolic process (GO:0006778)5.87268989
12heme biosynthetic process (GO:0006783)5.54970095
13regulation of nucleobase-containing compound transport (GO:0032239)4.89055783
143-UTR-mediated mRNA stabilization (GO:0070935)4.74020924
15heme metabolic process (GO:0042168)4.59099347
16myeloid cell development (GO:0061515)4.35542849
17nuclear pore complex assembly (GO:0051292)4.25185307
18definitive hemopoiesis (GO:0060216)4.13220698
19regulation of response to osmotic stress (GO:0047484)4.01754942
20mitotic chromosome condensation (GO:0007076)4.00706176
21negative regulation of erythrocyte differentiation (GO:0045647)3.90228868
22negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.71158000
23megakaryocyte development (GO:0035855)3.68659598
24positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.66232054
25embryonic process involved in female pregnancy (GO:0060136)3.64267824
26Golgi transport vesicle coating (GO:0048200)3.59182462
27COPI coating of Golgi vesicle (GO:0048205)3.59182462
28response to arsenic-containing substance (GO:0046685)3.58130592
29erythrocyte differentiation (GO:0030218)3.52401417
30modulation by symbiont of host cellular process (GO:0044068)3.50005380
31cellular response to virus (GO:0098586)3.49856505
32modulation by virus of host process (GO:0019054)3.42139535
33nuclear pore organization (GO:0006999)3.38200871
34tetrapyrrole metabolic process (GO:0033013)3.38132435
35DNA topological change (GO:0006265)3.32925209
36granulocyte differentiation (GO:0030851)3.23108482
37iron ion import (GO:0097286)3.19279988
38mitochondrial fusion (GO:0008053)3.14337886
39response to methylmercury (GO:0051597)3.12653830
40platelet formation (GO:0030220)3.11139682
41very-low-density lipoprotein particle assembly (GO:0034379)3.06872177
42protein localization to endosome (GO:0036010)3.03085367
43hepatocyte apoptotic process (GO:0097284)2.99152205
44proline biosynthetic process (GO:0006561)2.99074831
45positive regulation of erythrocyte differentiation (GO:0045648)2.98935964
46regulation of erythrocyte differentiation (GO:0045646)2.96887973
47cellular response to arsenic-containing substance (GO:0071243)2.93778656
48pore complex assembly (GO:0046931)2.86104684
49glycine transport (GO:0015816)2.86063326
50protein targeting to plasma membrane (GO:0072661)2.83779151
51RNA stabilization (GO:0043489)2.83688773
52mRNA stabilization (GO:0048255)2.83688773
53blood vessel maturation (GO:0001955)2.82931220
54protein export from nucleus (GO:0006611)2.76111986
55spliceosomal tri-snRNP complex assembly (GO:0000244)2.75937893
56positive regulation of protein homooligomerization (GO:0032464)2.74690479
57regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.71686045
58NIK/NF-kappaB signaling (GO:0038061)2.71411284
59negative regulation of execution phase of apoptosis (GO:1900118)2.70853728
60positive regulation of megakaryocyte differentiation (GO:0045654)2.61326149
61negative regulation of fatty acid biosynthetic process (GO:0045717)2.61277589
62regulation of chromatin binding (GO:0035561)2.58571258
63DNA unwinding involved in DNA replication (GO:0006268)2.58529182
64negative regulation of necroptotic process (GO:0060546)2.56240136
65embryonic hemopoiesis (GO:0035162)2.56094542
66positive regulation of granulocyte differentiation (GO:0030854)2.54213693
67determination of adult lifespan (GO:0008340)2.50171851
68positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.44387004
69cellular response to thyroid hormone stimulus (GO:0097067)2.44319896
70cellular protein complex localization (GO:0034629)2.42703199
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.42067536
72mitotic sister chromatid segregation (GO:0000070)2.40313085
73intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.40223058
74response to insecticide (GO:0017085)2.40178661
75endothelium development (GO:0003158)2.39292570
76response to lead ion (GO:0010288)2.36572833
77dosage compensation (GO:0007549)2.34992123
78low-density lipoprotein particle clearance (GO:0034383)2.34715643
79protein localization to chromosome, centromeric region (GO:0071459)2.33773262
80retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.33392276
81N-terminal protein amino acid acetylation (GO:0006474)2.33314176
82modulation by virus of host morphology or physiology (GO:0019048)2.32996217
83DNA replication initiation (GO:0006270)2.32753663
84positive regulation of DNA-dependent DNA replication (GO:2000105)2.32520535
85regulation of transforming growth factor beta1 production (GO:0032908)2.31439076
86pentose-phosphate shunt (GO:0006098)2.30699534
87regulation of translational fidelity (GO:0006450)2.29778027
88cytoskeletal anchoring at plasma membrane (GO:0007016)2.29080571
89negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.28555315
90Arp2/3 complex-mediated actin nucleation (GO:0034314)2.28400684
91nuclear envelope disassembly (GO:0051081)2.26977367
92membrane disassembly (GO:0030397)2.26977367
93negative regulation of protein localization to plasma membrane (GO:1903077)2.26736767
94protein-DNA complex disassembly (GO:0032986)2.26363491
95nucleosome disassembly (GO:0006337)2.26363491
96mitotic nuclear envelope disassembly (GO:0007077)2.25587950
97mitochondrial DNA metabolic process (GO:0032042)2.24199410
98regulation of early endosome to late endosome transport (GO:2000641)2.23983246
99regulation of histone H3-K27 methylation (GO:0061085)2.23727271
100chromosome condensation (GO:0030261)2.19925981

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.33887416
2GATA1_22025678_ChIP-Seq_K562_Human4.03444830
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.86570892
4GATA1_19941826_ChIP-Seq_K562_Human3.61566838
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.39296742
6MYC_22102868_ChIP-Seq_BL_Human3.03696441
7ZNF263_19887448_ChIP-Seq_K562_Human2.94127496
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46786278
9TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.43002243
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.23104996
11GATA2_19941826_ChIP-Seq_K562_Human2.15963849
12SCL_19346495_ChIP-Seq_HPC-7_Human2.11079030
13VDR_21846776_ChIP-Seq_THP-1_Human2.05127762
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99844724
15NCOR1_26117541_ChIP-Seq_K562_Human1.97774643
16ELK3_25401928_ChIP-Seq_HUVEC_Human1.87713706
17TCF7_22412390_ChIP-Seq_EML_Mouse1.86183808
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85447878
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82833351
20GATA1_19941827_ChIP-Seq_MEL_Mouse1.77127592
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74461648
22CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.72960494
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69095173
24GATA1_22383799_ChIP-Seq_G1ME_Mouse1.68549532
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.61234379
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57993186
27MAF_26560356_Chip-Seq_TH1_Human1.57036833
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56769431
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55583249
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.54281359
31TFEB_21752829_ChIP-Seq_HELA_Human1.52781925
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50339483
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46117196
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45441946
35CIITA_25753668_ChIP-Seq_RAJI_Human1.45321569
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43342023
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43011009
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42762948
39AR_21909140_ChIP-Seq_LNCAP_Human1.42351120
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41516202
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37975499
42* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37167370
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36808376
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36459203
45GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36386965
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36275109
47CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.36018135
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35417889
49CLOCK_20551151_ChIP-Seq_293T_Human1.35403010
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33816902
51KDM2B_26808549_Chip-Seq_DND41_Human1.32945813
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32030558
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31958742
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30629190
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29382002
56ATF3_27146783_Chip-Seq_COLON_Human1.28631747
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28370821
58UTX_26944678_Chip-Seq_JUKART_Human1.27650739
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26327734
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25288742
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.24675092
62VDR_24763502_ChIP-Seq_THP-1_Human1.23222359
63RACK7_27058665_Chip-Seq_MCF-7_Human1.22816508
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20892698
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20344051
66NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18963297
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17490512
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15863444
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15433285
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14898592
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13489661
72MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13463564
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.13298485
74KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.13057400
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12427301
76LXR_22292898_ChIP-Seq_THP-1_Human1.12022319
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11989053
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11657172
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11053316
80MAF_26560356_Chip-Seq_TH2_Human1.10410435
81DCP1A_22483619_ChIP-Seq_HELA_Human1.10357908
82* XRN2_22483619_ChIP-Seq_HELA_Human1.09800819
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08941930
84ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.05649351
85* MYB_26560356_Chip-Seq_TH1_Human1.03100850
86* CHD1_26751641_Chip-Seq_LNCaP_Human1.01815448
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01756489
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00578530
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00517062
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99823251
91KDM2B_26808549_Chip-Seq_JURKAT_Human0.99333201
92CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98344141
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98183338
94SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97175202
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97155116
96E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96990097
97KDM2B_26808549_Chip-Seq_K562_Human0.96540045
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94430480
99GATA4_21415370_ChIP-Seq_HL-1_Mouse0.93058149
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92278944

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.84301043
2MP0004147_increased_porphyrin_level6.28432866
3MP0005451_abnormal_body_composition4.19017995
4MP0005083_abnormal_biliary_tract3.58628577
5MP0008260_abnormal_autophagy3.00339529
6MP0001545_abnormal_hematopoietic_system2.59779316
7MP0005397_hematopoietic_system_phenotyp2.59779316
8MP0003303_peritoneal_inflammation2.43832200
9MP0005076_abnormal_cell_differentiation2.32237796
10MP0003111_abnormal_nucleus_morphology2.23809865
11MP0009278_abnormal_bone_marrow1.91277598
12MP0002009_preneoplasia1.82910109
13MP0004957_abnormal_blastocyst_morpholog1.77562910
14MP0004233_abnormal_muscle_weight1.74025578
15MP0003693_abnormal_embryo_hatching1.72323780
16MP0004808_abnormal_hematopoietic_stem1.69776423
17MP0003566_abnormal_cell_adhesion1.68859612
18MP0004185_abnormal_adipocyte_glucose1.56559349
19MP0002396_abnormal_hematopoietic_system1.54203236
20MP0003705_abnormal_hypodermis_morpholog1.53683552
21MP0010094_abnormal_chromosome_stability1.49043412
22MP0002877_abnormal_melanocyte_morpholog1.48461106
23MP0002822_catalepsy1.46461810
24MP0003221_abnormal_cardiomyocyte_apopto1.46405769
25MP0002166_altered_tumor_susceptibility1.44018157
26MP0001730_embryonic_growth_arrest1.41645643
27MP0003077_abnormal_cell_cycle1.40636390
28MP0010307_abnormal_tumor_latency1.40593133
29MP0004510_myositis1.39491779
30MP0005464_abnormal_platelet_physiology1.38967881
31MP0000747_muscle_weakness1.37922928
32MP0000685_abnormal_immune_system1.36844461
33MP0003191_abnormal_cellular_cholesterol1.27816561
34MP0000749_muscle_degeneration1.26789227
35MP0002398_abnormal_bone_marrow1.26313520
36MP0003984_embryonic_growth_retardation1.23239691
37MP0002086_abnormal_extraembryonic_tissu1.20304022
38MP0002138_abnormal_hepatobiliary_system1.17658696
39MP0002080_prenatal_lethality1.16652937
40MP0002088_abnormal_embryonic_growth/wei1.16156681
41MP0001672_abnormal_embryogenesis/_devel1.15435451
42MP0005380_embryogenesis_phenotype1.15435451
43MP0005636_abnormal_mineral_homeostasis1.14499812
44MP0003300_gastrointestinal_ulcer1.14025000
45MP0004087_abnormal_muscle_fiber1.13987488
46MP0000313_abnormal_cell_death1.12798150
47MP0010630_abnormal_cardiac_muscle1.12336665
48MP0009931_abnormal_skin_appearance1.12011091
49MP0002722_abnormal_immune_system1.11855365
50MP0005058_abnormal_lysosome_morphology1.11449952
51MP0005621_abnormal_cell_physiology1.08654779
52MP0001697_abnormal_embryo_size1.07283060
53MP0000350_abnormal_cell_proliferation1.07021208
54MP0010352_gastrointestinal_tract_polyps1.06700181
55MP0003453_abnormal_keratinocyte_physiol1.03256214
56MP0000689_abnormal_spleen_morphology1.02245444
57MP0002006_tumorigenesis1.01243927
58MP0001915_intracranial_hemorrhage1.01095306
59MP0003172_abnormal_lysosome_physiology1.00508855
60MP0004145_abnormal_muscle_electrophysio1.00128698
61MP0003828_pulmonary_edema0.99776324
62MP0000465_gastrointestinal_hemorrhage0.99517490
63MP0009333_abnormal_splenocyte_physiolog0.98036288
64MP0004264_abnormal_extraembryonic_tissu0.96798243
65MP0003186_abnormal_redox_activity0.96522117
66MP0005501_abnormal_skin_physiology0.95754164
67MP0008438_abnormal_cutaneous_collagen0.94851042
68MP0002429_abnormal_blood_cell0.94674520
69MP0000759_abnormal_skeletal_muscle0.92229415
70MP0004036_abnormal_muscle_relaxation0.90798321
71MP0005330_cardiomyopathy0.90091728
72MP0004084_abnormal_cardiac_muscle0.87877940
73MP0004947_skin_inflammation0.87604594
74MP0005384_cellular_phenotype0.87396023
75MP0003763_abnormal_thymus_physiology0.87181678
76MP0003950_abnormal_plasma_membrane0.86483194
77MP0002269_muscular_atrophy0.86453517
78MP0000703_abnormal_thymus_morphology0.86426211
79MP0009840_abnormal_foam_cell0.83882458
80MP0008004_abnormal_stomach_pH0.82934803
81MP0002019_abnormal_tumor_incidence0.82890961
82MP0003091_abnormal_cell_migration0.81974409
83MP0002332_abnormal_exercise_endurance0.81117343
84MP0009697_abnormal_copulation0.79786617
85MP0006138_congestive_heart_failure0.77466496
86MP0008775_abnormal_heart_ventricle0.76094884
87MP0000609_abnormal_liver_physiology0.72046113
88MP0001727_abnormal_embryo_implantation0.70715203
89MP0000490_abnormal_crypts_of0.69104822
90MP0005666_abnormal_adipose_tissue0.68051331
91MP0000598_abnormal_liver_morphology0.67690876
92MP0000266_abnormal_heart_morphology0.66957561
93MP0000750_abnormal_muscle_regeneration0.66922616
94MP0008995_early_reproductive_senescence0.66213389
95MP0002106_abnormal_muscle_physiology0.65919758
96MP0000358_abnormal_cell_content/0.64324472
97MP0001529_abnormal_vocalization0.63907216
98MP0004130_abnormal_muscle_cell0.63871509
99MP0000858_altered_metastatic_potential0.63143513
100MP0009384_cardiac_valve_regurgitation0.62568156

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)8.84286261
2Poikilocytosis (HP:0004447)7.06652918
3Reticulocytosis (HP:0001923)6.76389347
4Cholelithiasis (HP:0001081)4.73872306
5Abnormality of reticulocytes (HP:0004312)4.55634418
6Polycythemia (HP:0001901)4.35185205
7Microcytic anemia (HP:0001935)4.29289136
8Abnormal gallbladder morphology (HP:0012437)4.16393416
9Hypochromic microcytic anemia (HP:0004840)3.92533006
10Cholecystitis (HP:0001082)3.85080227
11Abnormal gallbladder physiology (HP:0012438)3.85080227
12Paralysis (HP:0003470)3.84731943
13Acanthocytosis (HP:0001927)3.79365213
14Ileus (HP:0002595)3.24011767
15Abnormal hemoglobin (HP:0011902)3.16659028
16Abnormality of the fingertips (HP:0001211)3.08351706
17Abnormality of the gallbladder (HP:0005264)3.07135676
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.07027515
19Centrally nucleated skeletal muscle fibers (HP:0003687)3.05850989
20Hyperbilirubinemia (HP:0002904)3.01874865
21Diaphragmatic weakness (HP:0009113)2.93760552
22Increased connective tissue (HP:0009025)2.92321278
23Insomnia (HP:0100785)2.90852368
24Hypochromic anemia (HP:0001931)2.86098959
25Hypertensive crisis (HP:0100735)2.71170424
26Abnormality of iron homeostasis (HP:0011031)2.51029493
27Exercise-induced myalgia (HP:0003738)2.46726698
28Distal lower limb amyotrophy (HP:0008944)2.42215301
29Cellulitis (HP:0100658)2.40792314
30Progressive muscle weakness (HP:0003323)2.38059296
31Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.36328365
32Hemorrhage of the eye (HP:0011885)2.36163503
33Myopathic facies (HP:0002058)2.35853052
34Nemaline bodies (HP:0003798)2.35477143
35Rhabdomyolysis (HP:0003201)2.33334335
36Muscle fiber inclusion bodies (HP:0100299)2.32980690
37Increased serum ferritin (HP:0003281)2.31272297
38Hyperacusis (HP:0010780)2.25953994
39Fatigue (HP:0012378)2.18448437
40Prolonged bleeding time (HP:0003010)2.13065171
41Abnormality of transition element cation homeostasis (HP:0011030)2.07357531
42Autoimmune hemolytic anemia (HP:0001890)2.01194692
43Rectal prolapse (HP:0002035)2.01074076
44Osteomyelitis (HP:0002754)1.93450295
45Abnormality of the thoracic spine (HP:0100711)1.92888062
46Abnormal number of erythroid precursors (HP:0012131)1.92869506
47Toxemia of pregnancy (HP:0100603)1.91427297
48Orthostatic hypotension (HP:0001278)1.90162016
49Pelvic girdle muscle weakness (HP:0003749)1.88310805
50Recurrent viral infections (HP:0004429)1.87999383
51Hyperkalemia (HP:0002153)1.87394734
52Gastrointestinal carcinoma (HP:0002672)1.86306154
53Malignant gastrointestinal tract tumors (HP:0006749)1.86306154
54Abnormality of cells of the erythroid lineage (HP:0012130)1.84829734
55Long palpebral fissure (HP:0000637)1.83778581
56Truncus arteriosus (HP:0001660)1.83001888
57Myoglobinuria (HP:0002913)1.81354690
58Gastrointestinal stroma tumor (HP:0100723)1.80785351
59Abnormality of the tricuspid valve (HP:0001702)1.80453018
60Abnormality of skeletal muscle fiber size (HP:0012084)1.78390597
61Distal lower limb muscle weakness (HP:0009053)1.76453853
62Achilles tendon contracture (HP:0001771)1.76011862
63Agammaglobulinemia (HP:0004432)1.75817152
64Pallor (HP:0000980)1.75304945
65Hypertriglyceridemia (HP:0002155)1.74608206
66Cutaneous photosensitivity (HP:0000992)1.74036929
67EMG: myopathic abnormalities (HP:0003458)1.73567749
68Hepatocellular carcinoma (HP:0001402)1.72038331
69Type 1 muscle fiber predominance (HP:0003803)1.71887211
70Slow saccadic eye movements (HP:0000514)1.71025185
71Difficulty climbing stairs (HP:0003551)1.70343568
72Dysmetric saccades (HP:0000641)1.69916426
73Viral hepatitis (HP:0006562)1.69839940
74Tetraparesis (HP:0002273)1.69739200
75Spontaneous hematomas (HP:0007420)1.69314635
76Ankyloglossia (HP:0010296)1.69297085
77Gastrointestinal infarctions (HP:0005244)1.67225570
78Myocardial infarction (HP:0001658)1.67206258
79Seborrheic dermatitis (HP:0001051)1.66854519
80Difficulty running (HP:0009046)1.63943273
81Leiomyosarcoma (HP:0100243)1.63695704
82Uterine leiomyosarcoma (HP:0002891)1.63695704
83Bowel incontinence (HP:0002607)1.62781938
84Epistaxis (HP:0000421)1.62609801
85Increased variability in muscle fiber diameter (HP:0003557)1.62379298
86Vertebral compression fractures (HP:0002953)1.61496647
87Increased mean platelet volume (HP:0011877)1.61477005
88Exercise-induced muscle cramps (HP:0003710)1.61371656
89Colitis (HP:0002583)1.60823419
90Long eyelashes (HP:0000527)1.60714215
91Thoracic kyphosis (HP:0002942)1.60573181
92Hyponatremia (HP:0002902)1.59027646
93Peripheral hypomyelination (HP:0007182)1.58544366
94Hypoparathyroidism (HP:0000829)1.58290849
95Gastrointestinal dysmotility (HP:0002579)1.57309142
96Abnormal large intestine physiology (HP:0012700)1.56541599
97Decreased motor nerve conduction velocity (HP:0003431)1.56288851
98Abnormal platelet volume (HP:0011876)1.55061364
99Abnormality of the Achilles tendon (HP:0005109)1.53412460
100Muscle fiber splitting (HP:0003555)1.53130577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK15.03885316
2PRPF4B3.66565216
3CDK123.07417856
4SMG12.75447282
5TAOK22.62720306
6ICK2.51081609
7TIE12.47200100
8MAP2K32.41584327
9SCYL22.17399571
10TRIB32.13345306
11IRAK32.05255793
12TAOK12.04518200
13PIM11.81983444
14MAP3K101.80589553
15BMX1.77409519
16STK41.75857805
17EEF2K1.71177679
18ERN11.67064078
19WNK11.57921501
20MAP3K111.43626694
21OBSCN1.31914990
22MAP3K81.31149503
23TTN1.27771327
24SIK11.27042534
25PBK1.25553680
26TRPM71.24374688
27MAP3K11.20379169
28CAMK1D1.14555981
29MTOR1.13172313
30CLK11.11904402
31IKBKE1.06073889
32KSR21.05377072
33MAP3K31.04074175
34RPS6KA51.03218265
35TTK1.01915371
36NEK91.00727257
37DYRK30.97088798
38TESK20.92202835
39TBK10.90832138
40MAP2K20.88693843
41KDR0.87422182
42MAPK110.86245141
43DYRK1B0.82422172
44GRK60.82288540
45HIPK20.78333191
46PIM20.78282541
47CDK40.76478453
48CHUK0.75995895
49RPS6KL10.74046073
50RPS6KC10.74046073
51CDK70.73353192
52PRKAA20.72410281
53NEK10.71749588
54MAP2K10.71127929
55RIPK40.70201333
56AKT20.69537274
57FGFR40.67648711
58PKN20.67638089
59MAP3K50.67476792
60ZAK0.67010003
61CDC70.64348188
62RPS6KB20.63160383
63MAP3K140.62376938
64SYK0.60692754
65CCNB10.60237940
66CDK60.60062132
67SGK30.58806073
68LATS20.58593932
69CHEK20.57297275
70CHEK10.57242492
71AURKA0.56872917
72MARK30.56161721
73AURKB0.55290384
74NEK20.54841092
75BRAF0.53946920
76NME20.52203139
77IKBKB0.51106950
78DAPK30.51054410
79RPS6KA20.49251313
80RPS6KA60.48771469
81KSR10.48748158
82VRK10.47889837
83BCKDK0.47053945
84LMTK20.45939781
85PRKAA10.45879101
86PLK10.45475396
87RAF10.44860756
88JAK30.44769601
89PLK30.43132969
90IRAK40.42651397
91ZAP700.42619388
92JAK20.42387669
93CDK90.40723572
94CAMK1G0.40546139
95MAPKAPK20.39998263
96MARK20.38321705
97CDK80.37079912
98LRRK20.36762143
99TAF10.36729868
100CDK20.34258963

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.49656820
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.58085657
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34233890
4Chronic myeloid leukemia_Homo sapiens_hsa052202.34086029
5Systemic lupus erythematosus_Homo sapiens_hsa053222.18727819
6Non-small cell lung cancer_Homo sapiens_hsa052232.03868008
7Bladder cancer_Homo sapiens_hsa052192.00238769
8Acute myeloid leukemia_Homo sapiens_hsa052211.92858924
9DNA replication_Homo sapiens_hsa030301.87911505
10Pancreatic cancer_Homo sapiens_hsa052121.85539480
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72987742
12Viral carcinogenesis_Homo sapiens_hsa052031.68296454
13Cell cycle_Homo sapiens_hsa041101.62716998
14Renal cell carcinoma_Homo sapiens_hsa052111.62229249
15Thyroid cancer_Homo sapiens_hsa052161.61579603
16B cell receptor signaling pathway_Homo sapiens_hsa046621.60328508
17Pentose phosphate pathway_Homo sapiens_hsa000301.53325386
18Alcoholism_Homo sapiens_hsa050341.52896293
19Central carbon metabolism in cancer_Homo sapiens_hsa052301.52769259
20Malaria_Homo sapiens_hsa051441.47056908
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46611011
22Small cell lung cancer_Homo sapiens_hsa052221.46233059
23Endometrial cancer_Homo sapiens_hsa052131.44284277
24HIF-1 signaling pathway_Homo sapiens_hsa040661.36317503
25Apoptosis_Homo sapiens_hsa042101.31421943
26Biosynthesis of amino acids_Homo sapiens_hsa012301.29680676
27Hepatitis B_Homo sapiens_hsa051611.28975684
28Longevity regulating pathway - mammal_Homo sapiens_hsa042111.24202342
29Carbon metabolism_Homo sapiens_hsa012001.23851635
30MicroRNAs in cancer_Homo sapiens_hsa052061.23814377
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20065988
32Mismatch repair_Homo sapiens_hsa034301.15430093
33Prostate cancer_Homo sapiens_hsa052151.14128898
34Fructose and mannose metabolism_Homo sapiens_hsa000511.14087055
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13787446
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12777837
37mTOR signaling pathway_Homo sapiens_hsa041501.12136846
38AMPK signaling pathway_Homo sapiens_hsa041521.10632891
39Adipocytokine signaling pathway_Homo sapiens_hsa049201.08726878
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08535271
41Shigellosis_Homo sapiens_hsa051311.08347726
42Herpes simplex infection_Homo sapiens_hsa051681.03757420
43HTLV-I infection_Homo sapiens_hsa051661.03155205
44FoxO signaling pathway_Homo sapiens_hsa040680.98997976
45Insulin signaling pathway_Homo sapiens_hsa049100.98471931
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94843854
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94114542
48One carbon pool by folate_Homo sapiens_hsa006700.93916736
49p53 signaling pathway_Homo sapiens_hsa041150.93819255
50Epstein-Barr virus infection_Homo sapiens_hsa051690.93577188
51Spliceosome_Homo sapiens_hsa030400.93398524
52Nucleotide excision repair_Homo sapiens_hsa034200.92856243
53Influenza A_Homo sapiens_hsa051640.91931307
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91661073
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90880861
56Inositol phosphate metabolism_Homo sapiens_hsa005620.90328181
57Hepatitis C_Homo sapiens_hsa051600.89630974
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88932434
59Measles_Homo sapiens_hsa051620.87465568
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87075126
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.86018964
62Insulin resistance_Homo sapiens_hsa049310.85944977
63Prolactin signaling pathway_Homo sapiens_hsa049170.85689484
64Regulation of autophagy_Homo sapiens_hsa041400.84612094
65Glioma_Homo sapiens_hsa052140.80679293
66Galactose metabolism_Homo sapiens_hsa000520.80588073
67mRNA surveillance pathway_Homo sapiens_hsa030150.78445547
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.77854626
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77756572
70Base excision repair_Homo sapiens_hsa034100.76898397
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74964797
72ErbB signaling pathway_Homo sapiens_hsa040120.74533387
73RNA transport_Homo sapiens_hsa030130.74049344
74VEGF signaling pathway_Homo sapiens_hsa043700.73985046
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73580978
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.72412157
77Primary immunodeficiency_Homo sapiens_hsa053400.71394509
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71391014
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68972502
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66622959
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.65614383
82Adherens junction_Homo sapiens_hsa045200.65363229
83Colorectal cancer_Homo sapiens_hsa052100.62992979
84Notch signaling pathway_Homo sapiens_hsa043300.60054682
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59655902
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59386352
87N-Glycan biosynthesis_Homo sapiens_hsa005100.59037399
88Proteoglycans in cancer_Homo sapiens_hsa052050.58707083
89Leishmaniasis_Homo sapiens_hsa051400.58337472
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58152393
91Toxoplasmosis_Homo sapiens_hsa051450.56429780
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55721366
93Focal adhesion_Homo sapiens_hsa045100.55139884
94Melanoma_Homo sapiens_hsa052180.50573309
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49994460
96T cell receptor signaling pathway_Homo sapiens_hsa046600.49370500
97TNF signaling pathway_Homo sapiens_hsa046680.46813071
98Other glycan degradation_Homo sapiens_hsa005110.46279194
99Non-homologous end-joining_Homo sapiens_hsa034500.43584396
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41662725

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