NUDT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)4.84214480
2telomere maintenance via semi-conservative replication (GO:0032201)4.77006906
3DNA strand elongation involved in DNA replication (GO:0006271)4.62584913
4ribosomal small subunit assembly (GO:0000028)4.56432282
5DNA strand elongation (GO:0022616)4.45613223
6chaperone-mediated protein transport (GO:0072321)4.36485312
7DNA replication initiation (GO:0006270)4.34971601
8CENP-A containing nucleosome assembly (GO:0034080)4.31603087
9viral transcription (GO:0019083)4.27986485
10telomere maintenance via recombination (GO:0000722)4.26447582
11translational termination (GO:0006415)4.16040641
12chromatin remodeling at centromere (GO:0031055)4.15926808
13positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.13066592
14maturation of SSU-rRNA (GO:0030490)4.07821212
15cotranslational protein targeting to membrane (GO:0006613)4.05659337
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.02960378
17mitotic metaphase plate congression (GO:0007080)3.98948994
18protein targeting to ER (GO:0045047)3.97989342
19regulation of mitochondrial translation (GO:0070129)3.97687781
20mitotic recombination (GO:0006312)3.97027027
21establishment of integrated proviral latency (GO:0075713)3.95309589
22ribosomal large subunit biogenesis (GO:0042273)3.93505726
23proteasome assembly (GO:0043248)3.91347027
24kinetochore organization (GO:0051383)3.83376130
25nucleotide-excision repair, DNA gap filling (GO:0006297)3.80852686
26protein localization to kinetochore (GO:0034501)3.78081102
27protein localization to endoplasmic reticulum (GO:0070972)3.77102150
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.76447488
29purine nucleobase biosynthetic process (GO:0009113)3.72362218
30formation of translation preinitiation complex (GO:0001731)3.69093736
31respiratory electron transport chain (GO:0022904)3.68926496
32rRNA modification (GO:0000154)3.68387106
33regulation of cellular amino acid metabolic process (GO:0006521)3.64258324
34telomere maintenance via telomere lengthening (GO:0010833)3.63545261
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.63180353
36kinetochore assembly (GO:0051382)3.62913251
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.59244289
38termination of RNA polymerase III transcription (GO:0006386)3.59244289
39electron transport chain (GO:0022900)3.58989114
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.57897221
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.57897221
42signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.57897221
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.57887781
44transcription-coupled nucleotide-excision repair (GO:0006283)3.57375481
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.56879393
46positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.56208693
47intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54931529
48signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54931529
49metaphase plate congression (GO:0051310)3.54853204
50spliceosomal snRNP assembly (GO:0000387)3.54391309
51translational elongation (GO:0006414)3.53079606
52signal transduction involved in DNA damage checkpoint (GO:0072422)3.50320587
53signal transduction involved in DNA integrity checkpoint (GO:0072401)3.50320587
547-methylguanosine mRNA capping (GO:0006370)3.50067456
55RNA capping (GO:0036260)3.49595670
567-methylguanosine RNA capping (GO:0009452)3.49595670
57DNA replication-independent nucleosome organization (GO:0034724)3.48223760
58DNA replication-independent nucleosome assembly (GO:0006336)3.48223760
59ATP synthesis coupled proton transport (GO:0015986)3.47976483
60energy coupled proton transport, down electrochemical gradient (GO:0015985)3.47976483
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46154571
62DNA ligation (GO:0006266)3.45404443
63ribosome assembly (GO:0042255)3.44149926
64signal transduction involved in cell cycle checkpoint (GO:0072395)3.43625227
65positive regulation of ligase activity (GO:0051351)3.43536215
66spliceosomal complex assembly (GO:0000245)3.40209961
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37185779
68deoxyribonucleotide biosynthetic process (GO:0009263)3.34580995
69rRNA methylation (GO:0031167)3.34116789
70cellular protein complex disassembly (GO:0043624)3.33736290
71histone exchange (GO:0043486)3.33584126
72ribonucleoprotein complex biogenesis (GO:0022613)3.33271807
73protein localization to chromosome, centromeric region (GO:0071459)3.32910522
74translation (GO:0006412)3.32500392
75mitochondrial respiratory chain complex assembly (GO:0033108)3.32415272
76regulation of ubiquitin-protein transferase activity (GO:0051438)3.31207378
77protein complex biogenesis (GO:0070271)3.31055281
78IMP biosynthetic process (GO:0006188)3.31005895
79protein neddylation (GO:0045116)3.30832190
80DNA replication checkpoint (GO:0000076)3.30521840
81translational initiation (GO:0006413)3.29838723
82protein targeting to mitochondrion (GO:0006626)3.28354992
83viral life cycle (GO:0019058)3.25916200
84mitotic sister chromatid segregation (GO:0000070)3.25341502
85GTP biosynthetic process (GO:0006183)3.21665824
86regulation of ligase activity (GO:0051340)3.21598135
87DNA unwinding involved in DNA replication (GO:0006268)3.21219893
88deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.20589785
89establishment of viral latency (GO:0019043)3.17305087
90nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.16917637
91rRNA processing (GO:0006364)3.16682493
92DNA damage response, detection of DNA damage (GO:0042769)3.16379333
93DNA deamination (GO:0045006)3.12772715
94viral mRNA export from host cell nucleus (GO:0046784)3.11603897
95maturation of 5.8S rRNA (GO:0000460)3.11555554
96nucleobase-containing small molecule interconversion (GO:0015949)3.10374915
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09428582
98DNA replication-dependent nucleosome organization (GO:0034723)3.08773117
99DNA replication-dependent nucleosome assembly (GO:0006335)3.08773117
100termination of RNA polymerase I transcription (GO:0006363)3.04407185
101transcription elongation from RNA polymerase I promoter (GO:0006362)3.04226687
102rRNA metabolic process (GO:0016072)3.01007970
103UTP biosynthetic process (GO:0006228)2.99784007
104nucleobase biosynthetic process (GO:0046112)2.99648017
105respiratory chain complex IV assembly (GO:0008535)2.98986390
106negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.98888822
107L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97842083
108pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.95917617
109pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.93154170
110cellular component biogenesis (GO:0044085)2.92571782
111transcription from RNA polymerase I promoter (GO:0006360)2.92201111
112protein complex disassembly (GO:0043241)2.88902420
113regulation of nuclear cell cycle DNA replication (GO:0033262)2.88530185
114cullin deneddylation (GO:0010388)2.86131926
115establishment of protein localization to mitochondrial membrane (GO:0090151)2.85928772
116pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.85284393
117guanosine-containing compound biosynthetic process (GO:1901070)2.85225102
118mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83134200
119mitochondrial respiratory chain complex I assembly (GO:0032981)2.83134200
120NADH dehydrogenase complex assembly (GO:0010257)2.83134200
121pseudouridine synthesis (GO:0001522)2.82007633
122protein K6-linked ubiquitination (GO:0085020)2.81780415
123macromolecular complex disassembly (GO:0032984)2.80443515
124anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80123191
125protein-cofactor linkage (GO:0018065)2.79551983
126central nervous system myelination (GO:0022010)2.79515205
127axon ensheathment in central nervous system (GO:0032291)2.79515205
128negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79275545
129negative regulation of ligase activity (GO:0051352)2.79275545
130regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78817470
131peptidyl-histidine modification (GO:0018202)2.77529404
132cell cycle G1/S phase transition (GO:0044843)2.77158663
133G1/S transition of mitotic cell cycle (GO:0000082)2.77158663

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.10191136
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.73279140
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.54264000
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.97394025
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.75016324
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.66021198
7* GABP_17652178_ChIP-ChIP_JURKAT_Human3.62211971
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.26209575
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24911930
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.18122504
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.08469822
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.95517931
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.94550191
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.91945177
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84720102
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.77351320
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65727881
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62838629
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55528245
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54217925
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52892981
22* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47842589
23ELK1_19687146_ChIP-ChIP_HELA_Human2.38999837
24VDR_23849224_ChIP-Seq_CD4+_Human2.32863335
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.19422128
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16697695
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09025291
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06007748
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04010818
30* XRN2_22483619_ChIP-Seq_HELA_Human2.02735729
31* SRF_21415370_ChIP-Seq_HL-1_Mouse1.96868815
32* FOXP3_21729870_ChIP-Seq_TREG_Human1.96602628
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93595707
34DCP1A_22483619_ChIP-Seq_HELA_Human1.92997242
35* TTF2_22483619_ChIP-Seq_HELA_Human1.91127908
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89015616
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86581883
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76156419
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.72855619
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72674983
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67265641
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62202576
43MYC_18940864_ChIP-ChIP_HL60_Human1.56398140
44IRF1_19129219_ChIP-ChIP_H3396_Human1.55868799
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54762364
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.54369551
47AR_21909140_ChIP-Seq_LNCAP_Human1.48003346
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46995566
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44545184
50* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44519947
51* GABP_19822575_ChIP-Seq_HepG2_Human1.43930115
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43127422
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42329091
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41734218
55* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36894987
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35098946
57* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.32785442
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32024452
59* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23834582
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21830667
61* ELK1_22589737_ChIP-Seq_MCF10A_Human1.16478044
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14909073
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13629274
64* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12592514
65EWS_26573619_Chip-Seq_HEK293_Human1.11420289
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10780254
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08094709
68FUS_26573619_Chip-Seq_HEK293_Human1.08077736
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04177834
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04177834
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04177834
72* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00539561
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97988753
74TFEB_21752829_ChIP-Seq_HELA_Human0.97427217
75ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96103749
76VDR_22108803_ChIP-Seq_LS180_Human0.96058979
77SOX17_20123909_ChIP-Seq_XEN_Mouse0.94872340
78SOX2_16153702_ChIP-ChIP_HESCs_Human0.94833877
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94784707
80TP63_19390658_ChIP-ChIP_HaCaT_Human0.93703328
81FLI1_27457419_Chip-Seq_LIVER_Mouse0.91091817
82* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90374693
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89987626
84PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88546951
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87693759
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86694779
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86181915
88KDM5A_27292631_Chip-Seq_BREAST_Human0.85393369
89KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83566996
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82999208
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81126451
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80993139
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80309033
94NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78294416
95SALL1_21062744_ChIP-ChIP_HESCs_Human0.78244633
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.75997503
97BMI1_23680149_ChIP-Seq_NPCS_Mouse0.75211774
98RBPJ_22232070_ChIP-Seq_NCS_Mouse0.74796038
99CIITA_25753668_ChIP-Seq_RAJI_Human0.74519001
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.72365775
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72126212
102SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71376788
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.70728149
104* NANOG_16153702_ChIP-ChIP_HESCs_Human0.70039454
105* ELF5_23300383_ChIP-Seq_T47D_Human0.69218165
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.69005173
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.67152475
108TBX5_21415370_ChIP-Seq_HL-1_Mouse0.65030298
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.64437689
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.64358613
111* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.63747820
112TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.62252611
113POU3F2_20337985_ChIP-ChIP_501MEL_Human0.61113974
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.60769086
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.58739132
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.57514881

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.28713134
2MP0009379_abnormal_foot_pigmentation3.92805341
3MP0010094_abnormal_chromosome_stability3.73591533
4MP0003136_yellow_coat_color3.69719499
5MP0003693_abnormal_embryo_hatching3.34830726
6MP0005409_darkened_coat_color3.18366540
7MP0004957_abnormal_blastocyst_morpholog2.90969082
8MP0008058_abnormal_DNA_repair2.83762237
9MP0003111_abnormal_nucleus_morphology2.78793901
10MP0003077_abnormal_cell_cycle2.76643243
11MP0006292_abnormal_olfactory_placode2.74813114
12MP0000566_synostosis2.66457048
13MP0008932_abnormal_embryonic_tissue2.56929001
14MP0008007_abnormal_cellular_replicative2.22217943
15MP0001986_abnormal_taste_sensitivity2.14323045
16MP0003718_maternal_effect2.05676510
17MP0001529_abnormal_vocalization2.05164992
18MP0008877_abnormal_DNA_methylation2.01644781
19MP0005408_hypopigmentation1.97551493
20MP0004147_increased_porphyrin_level1.92739628
21MP0001188_hyperpigmentation1.91346347
22MP0003786_premature_aging1.82363589
23MP0006035_abnormal_mitochondrial_morpho1.76166127
24MP0004381_abnormal_hair_follicle1.64571771
25MP0000372_irregular_coat_pigmentation1.63394354
26MP0001905_abnormal_dopamine_level1.60319201
27MP0003123_paternal_imprinting1.58930707
28MP0002102_abnormal_ear_morphology1.53619341
29MP0003315_abnormal_perineum_morphology1.52493956
30MP0002938_white_spotting1.48860180
31MP0005171_absent_coat_pigmentation1.48734448
32MP0002163_abnormal_gland_morphology1.43683835
33MP0004133_heterotaxia1.41711655
34MP0002396_abnormal_hematopoietic_system1.39560999
35MP0002160_abnormal_reproductive_system1.39466685
36MP0005379_endocrine/exocrine_gland_phen1.37098157
37MP0000015_abnormal_ear_pigmentation1.36451334
38MP0003121_genomic_imprinting1.32988776
39MP0000358_abnormal_cell_content/1.32753418
40MP0003186_abnormal_redox_activity1.31966066
41MP0002080_prenatal_lethality1.31186764
42MP0002095_abnormal_skin_pigmentation1.29422681
43MP0003937_abnormal_limbs/digits/tail_de1.27816195
44MP0001485_abnormal_pinna_reflex1.26912779
45MP0003806_abnormal_nucleotide_metabolis1.25081200
46MP0003567_abnormal_fetal_cardiomyocyte1.24323603
47MP0002638_abnormal_pupillary_reflex1.21649670
48MP0008789_abnormal_olfactory_epithelium1.20719935
49MP0005075_abnormal_melanosome_morpholog1.20133807
50MP0010307_abnormal_tumor_latency1.17631358
51MP0001346_abnormal_lacrimal_gland1.16909703
52MP0001764_abnormal_homeostasis1.16262220
53MP0002009_preneoplasia1.13678346
54MP0003984_embryonic_growth_retardation1.13502580
55MP0000350_abnormal_cell_proliferation1.11520492
56MP0000049_abnormal_middle_ear1.10034917
57MP0002088_abnormal_embryonic_growth/wei1.09836979
58MP0002210_abnormal_sex_determination1.09747318
59MP0004142_abnormal_muscle_tone1.09135923
60MP0002084_abnormal_developmental_patter1.08307861
61MP0002751_abnormal_autonomic_nervous1.08073663
62MP0003941_abnormal_skin_development1.05523989
63MP0002697_abnormal_eye_size1.03001978
64MP0005174_abnormal_tail_pigmentation1.00862467
65MP0009697_abnormal_copulation1.00553798
66MP0010030_abnormal_orbit_morphology0.99555732
67MP0005084_abnormal_gallbladder_morpholo0.99256350
68MP0003950_abnormal_plasma_membrane0.99078058
69MP0001881_abnormal_mammary_gland0.97846752
70MP0005395_other_phenotype0.96440090
71MP0005423_abnormal_somatic_nervous0.95357892
72MP0000490_abnormal_crypts_of0.94295086
73MP0001286_abnormal_eye_development0.93429045
74MP0002277_abnormal_respiratory_mucosa0.91637821
75MP0005389_reproductive_system_phenotype0.91407131
76MP0002111_abnormal_tail_morphology0.88464333
77MP0006276_abnormal_autonomic_nervous0.88299686
78MP0003938_abnormal_ear_development0.88134362
79MP0009672_abnormal_birth_weight0.87260770
80MP0001145_abnormal_male_reproductive0.86564796
81MP0006072_abnormal_retinal_apoptosis0.86448405
82MP0001186_pigmentation_phenotype0.85632933
83MP0004742_abnormal_vestibular_system0.85565326
84MP0003890_abnormal_embryonic-extraembry0.85157914
85MP0005332_abnormal_amino_acid0.85138443
86MP0001853_heart_inflammation0.83602398
87MP0002132_abnormal_respiratory_system0.83509229
88MP0000313_abnormal_cell_death0.82968092
89MP0003195_calcinosis0.82591476
90MP0001727_abnormal_embryo_implantation0.81820038
91MP0005501_abnormal_skin_physiology0.81523506
92MP0000920_abnormal_myelination0.81317084
93MP0000653_abnormal_sex_gland0.80706375
94MP0001730_embryonic_growth_arrest0.80676853
95MP0002249_abnormal_larynx_morphology0.80510702
96MP0001929_abnormal_gametogenesis0.79000826
97MP0000631_abnormal_neuroendocrine_gland0.78368016
98MP0006036_abnormal_mitochondrial_physio0.76465079
99MP0002233_abnormal_nose_morphology0.74007059
100MP0009250_abnormal_appendicular_skeleto0.73435433
101MP0000647_abnormal_sebaceous_gland0.73179999
102MP0001293_anophthalmia0.71044840
103MP0000026_abnormal_inner_ear0.70901042
104MP0001119_abnormal_female_reproductive0.70812161
105MP0002086_abnormal_extraembryonic_tissu0.70246379
106MP0008875_abnormal_xenobiotic_pharmacok0.70135832
107MP0004197_abnormal_fetal_growth/weight/0.69975128
108MP0001697_abnormal_embryo_size0.68951020
109MP0005394_taste/olfaction_phenotype0.67909687
110MP0005499_abnormal_olfactory_system0.67909687
111MP0002177_abnormal_outer_ear0.67387235
112MP0009333_abnormal_splenocyte_physiolog0.67367282
113MP0003880_abnormal_central_pattern0.67336151
114MP0000762_abnormal_tongue_morphology0.67239266
115MP0005253_abnormal_eye_physiology0.65397022
116MP0002085_abnormal_embryonic_tissue0.65101019
117MP0003011_delayed_dark_adaptation0.64609199
118MP0001672_abnormal_embryogenesis/_devel0.64278678
119MP0005380_embryogenesis_phenotype0.64278678
120MP0008995_early_reproductive_senescence0.63668908
121MP0009053_abnormal_anal_canal0.63667976
122MP0002796_impaired_skin_barrier0.62419975
123MP0008260_abnormal_autophagy0.62220077
124MP0002019_abnormal_tumor_incidence0.62166461
125MP0003763_abnormal_thymus_physiology0.61788792
126MP0002234_abnormal_pharynx_morphology0.61698656
127MP0001963_abnormal_hearing_physiology0.61145934
128MP0002876_abnormal_thyroid_physiology0.58669840
129MP0006054_spinal_hemorrhage0.57811795
130MP0003724_increased_susceptibility_to0.57577913
131MP0002148_abnormal_hypersensitivity_rea0.56778380
132MP0005384_cellular_phenotype0.55574118
133MP0002092_abnormal_eye_morphology0.55084665
134MP0008873_increased_physiological_sensi0.53678016
135MP0003936_abnormal_reproductive_system0.52329568
136MP0000537_abnormal_urethra_morphology0.51752904
137MP0005391_vision/eye_phenotype0.51518986
138MP0000627_abnormal_mammary_gland0.51240734
139MP0002006_tumorigenesis0.51003893
140MP0003755_abnormal_palate_morphology0.49386136

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.27377454
2Duplicated collecting system (HP:0000081)4.20017211
3Abnormality of cells of the erythroid lineage (HP:0012130)4.02397336
4Abnormal number of erythroid precursors (HP:0012131)3.94894679
5Abnormality of the renal collecting system (HP:0004742)3.77885950
6Cerebral edema (HP:0002181)3.71887509
7Chromsome breakage (HP:0040012)3.67853829
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61328301
9Acute necrotizing encephalopathy (HP:0006965)3.47428538
10Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.35550444
11Mitochondrial inheritance (HP:0001427)3.30725074
12Abnormality of methionine metabolism (HP:0010901)3.16131355
13Increased hepatocellular lipid droplets (HP:0006565)3.14781572
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.10568768
15Macrocytic anemia (HP:0001972)3.10014808
16Hepatocellular necrosis (HP:0001404)3.04008237
173-Methylglutaconic aciduria (HP:0003535)3.02876197
18Breast hypoplasia (HP:0003187)3.00532145
19Type I transferrin isoform profile (HP:0003642)2.96162720
20Lactic acidosis (HP:0003128)2.95330028
21Abnormal mitochondria in muscle tissue (HP:0008316)2.92958690
22Increased CSF lactate (HP:0002490)2.91525463
23Birth length less than 3rd percentile (HP:0003561)2.90068983
24Progressive macrocephaly (HP:0004481)2.78280234
25Renal Fanconi syndrome (HP:0001994)2.76430801
26Colon cancer (HP:0003003)2.73135911
2711 pairs of ribs (HP:0000878)2.62868371
28Acute encephalopathy (HP:0006846)2.59608796
29Meckel diverticulum (HP:0002245)2.58349580
30Aplasia/Hypoplasia of the sacrum (HP:0008517)2.57179525
31Abnormality of the preputium (HP:0100587)2.55809803
32Lipid accumulation in hepatocytes (HP:0006561)2.53881786
33Cerebral hypomyelination (HP:0006808)2.53486835
34Parakeratosis (HP:0001036)2.53095584
35Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.52847707
36Abnormality of aspartate family amino acid metabolism (HP:0010899)2.52823842
37Aplastic anemia (HP:0001915)2.50710630
38Abnormality of chromosome stability (HP:0003220)2.49159588
39Pallor (HP:0000980)2.48464049
40Abnormality of the ileum (HP:0001549)2.48325908
41Hepatic necrosis (HP:0002605)2.47532845
42Exertional dyspnea (HP:0002875)2.47526920
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.45615251
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.45615251
45Increased serum pyruvate (HP:0003542)2.43334787
46Abnormality of glycolysis (HP:0004366)2.43334787
47Degeneration of anterior horn cells (HP:0002398)2.43112676
48Abnormality of the anterior horn cell (HP:0006802)2.43112676
49Increased serum lactate (HP:0002151)2.40911969
50Absent radius (HP:0003974)2.36791177
51Supernumerary spleens (HP:0009799)2.29936364
52Exercise intolerance (HP:0003546)2.29672212
53Triphalangeal thumb (HP:0001199)2.26994290
54Absent forearm bone (HP:0003953)2.25822044
55Aplasia involving forearm bones (HP:0009822)2.25822044
56Abnormal lung lobation (HP:0002101)2.25682146
57Optic disc pallor (HP:0000543)2.25589798
58Increased muscle lipid content (HP:0009058)2.23427552
59Lethargy (HP:0001254)2.21945288
60Multiple enchondromatosis (HP:0005701)2.21574459
61Reduced antithrombin III activity (HP:0001976)2.20019190
62True hermaphroditism (HP:0010459)2.19593055
63Congenital, generalized hypertrichosis (HP:0004540)2.19402383
64Sparse eyelashes (HP:0000653)2.19065963
65Megaloblastic anemia (HP:0001889)2.18657809
66Asplenia (HP:0001746)2.16867094
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.15608716
68Abnormality of serum amino acid levels (HP:0003112)2.14754828
69Absent thumb (HP:0009777)2.13674403
70Nephroblastoma (Wilms tumor) (HP:0002667)2.10749400
71Pancreatic cysts (HP:0001737)2.10680138
72Pancreatic fibrosis (HP:0100732)2.09732821
73Abnormality of the heme biosynthetic pathway (HP:0010472)2.09247845
74Abnormality of the pons (HP:0007361)2.07070668
75Patellar aplasia (HP:0006443)2.06250152
76Duplication of thumb phalanx (HP:0009942)2.05869619
77Microvesicular hepatic steatosis (HP:0001414)2.04147624
78Abnormality of the labia minora (HP:0012880)2.03701877
79Premature graying of hair (HP:0002216)2.00404148
80Bone marrow hypocellularity (HP:0005528)2.00223307
81Methylmalonic acidemia (HP:0002912)1.99626204
82Abnormality of secondary sexual hair (HP:0009888)1.99212796
83Abnormality of the axillary hair (HP:0100134)1.99212796
84CNS demyelination (HP:0007305)1.97297228
85Embryonal renal neoplasm (HP:0011794)1.96673217
86Small intestinal stenosis (HP:0012848)1.96213425
87Duodenal stenosis (HP:0100867)1.96213425
88Aplasia/Hypoplasia of the spleen (HP:0010451)1.96111081
89Hypoplasia of the pons (HP:0012110)1.95782977
90Respiratory difficulties (HP:0002880)1.94493439
91Rough bone trabeculation (HP:0100670)1.93479050
92Aplasia/hypoplasia of the uterus (HP:0008684)1.93250564
93Oral leukoplakia (HP:0002745)1.92649030
94Adrenal hypoplasia (HP:0000835)1.92512791
95Aplasia/Hypoplasia of the patella (HP:0006498)1.91476576
96Abnormal protein glycosylation (HP:0012346)1.89261062
97Abnormal glycosylation (HP:0012345)1.89261062
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89261062
99Abnormal protein N-linked glycosylation (HP:0012347)1.89261062
100Methylmalonic aciduria (HP:0012120)1.86970497
101Abnormality of the duodenum (HP:0002246)1.86294569
102Clubbing of toes (HP:0100760)1.86138965
103Horseshoe kidney (HP:0000085)1.85754988
104Leukodystrophy (HP:0002415)1.84922508
105Increased intramyocellular lipid droplets (HP:0012240)1.84887207
106Respiratory failure (HP:0002878)1.83537188
107Cleft eyelid (HP:0000625)1.82833492
108Abnormality of sulfur amino acid metabolism (HP:0004339)1.82785872
109Preaxial hand polydactyly (HP:0001177)1.81837642
110X-linked dominant inheritance (HP:0001423)1.79598953
111Abnormality of the septum pellucidum (HP:0007375)1.79239409
112Pancytopenia (HP:0001876)1.79148024
113Cellular immunodeficiency (HP:0005374)1.78172050
114Pancreatic islet-cell hyperplasia (HP:0004510)1.77600423
115Abnormal number of incisors (HP:0011064)1.77599415
116Congenital ichthyosiform erythroderma (HP:0007431)1.77105891
117Sensory axonal neuropathy (HP:0003390)1.76869902
118Septo-optic dysplasia (HP:0100842)1.76829564
119Abnormality of renal resorption (HP:0011038)1.76497034
120Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76336211
121Abnormality of alanine metabolism (HP:0010916)1.76336211
122Hyperalaninemia (HP:0003348)1.76336211
123Hyperphosphaturia (HP:0003109)1.74328339
124Aplasia/Hypoplasia of the tibia (HP:0005772)1.71892354
125Neoplasm of the adrenal gland (HP:0100631)1.70665266
126Facial cleft (HP:0002006)1.70625537
127Degeneration of the lateral corticospinal tracts (HP:0002314)1.70491384
128Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.70491384
129Hypoglycemic coma (HP:0001325)1.70256328
130Amniotic constriction ring (HP:0009775)1.70145141
131Abnormality of placental membranes (HP:0011409)1.70145141
132Abnormal respiratory motile cilium morphology (HP:0005938)1.69934436
133Abnormal respiratory epithelium morphology (HP:0012253)1.69934436
134Myelodysplasia (HP:0002863)1.69318647
135Abnormal trabecular bone morphology (HP:0100671)1.68856969
136Hyperglycinemia (HP:0002154)1.68749713
137Testicular atrophy (HP:0000029)1.68451667
138Ectopic kidney (HP:0000086)1.68153248
139Patchy hypopigmentation of hair (HP:0011365)1.67465378
140Sloping forehead (HP:0000340)1.66792167

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.64815717
2BUB13.33397228
3SRPK13.26229400
4STK163.09062659
5VRK12.90452258
6CDC72.76245224
7NEK12.71297432
8WEE12.55323163
9MKNK12.49491815
10PBK2.44601069
11CASK2.43216863
12EIF2AK32.22511177
13MKNK22.16509704
14TLK12.15970487
15EIF2AK12.15938341
16ZAK1.99263237
17PLK41.91436728
18MST41.88128776
19IRAK41.73837315
20CLK11.72484863
21MAP3K121.63269986
22TAF11.62657652
23STK391.60462641
24NME21.55021761
25NUAK11.53845898
26BMPR21.50673215
27TTK1.50206972
28CDK81.47878970
29PLK31.47281063
30PASK1.41760366
31IRAK31.38178744
32NEK61.30594518
33PDK21.22434999
34PLK11.21384471
35CHEK21.18461544
36EIF2AK21.18101036
37PAK41.16659586
38PIM21.15116233
39MAPKAPK51.14983717
40BMPR1B1.14901233
41BCR1.13996119
42CDK71.11332670
43TSSK61.10956129
44TNIK1.10655232
45AURKA1.10633256
46YES11.09057555
47AURKB1.08001438
48ATR1.06314104
49BRSK21.05929148
50BRAF1.02916259
51BCKDK1.00601561
52TRIM280.99986227
53TESK20.98345412
54DYRK20.97422131
55LIMK10.97011968
56NME10.96970614
57RPS6KA50.96716223
58ADRBK20.94062652
59PRPF4B0.93846059
60WNK30.90074375
61OXSR10.89818441
62PNCK0.86585565
63NEK20.86585495
64AKT30.85161258
65KDR0.85127945
66IRAK20.84206612
67DYRK30.81687977
68MAP4K20.80081747
69RPS6KB20.79537332
70CSNK1G30.79133626
71CSNK2A10.74181801
72CDK30.73864678
73STK40.73658182
74CCNB10.72154805
75CSNK2A20.70407337
76PLK20.67560468
77OBSCN0.67005360
78IRAK10.66360679
79TEC0.66085856
80CHEK10.64813777
81DAPK10.63790581
82ATM0.61845092
83CSNK1G10.58521598
84TXK0.57839211
85SCYL20.55837695
86ILK0.55101726
87ABL20.54360954
88ALK0.53545582
89BRD40.53444331
90MUSK0.53204164
91MAPK130.50408637
92ACVR1B0.49772618
93NEK90.49762097
94UHMK10.49060313
95LRRK20.48492829
96CAMK2B0.48180588
97STK30.47613718
98MYLK0.47269018
99ERBB30.46320780
100ERBB40.46273343
101PIM10.46160128
102MAP3K140.45283033
103CDK190.45161470
104FGFR10.44694722
105BRSK10.44588363
106PAK10.43791944
107MELK0.43549032
108RPS6KA40.42932096
109CDK10.42838953
110GRK10.41225091
111TGFBR10.39615778
112ROCK20.39538293
113PRKCI0.36209039
114CDK20.36054633
115MAP3K80.35196997
116CAMK2D0.35023502
117CDK40.34955359
118PKN10.34423708
119MAPKAPK20.34036713
120NLK0.33614401
121STK38L0.33470380
122CSNK1A1L0.33042978
123IKBKB0.33018353
124SMG10.32117752
125STK100.32030160
126CSNK1E0.31895635
127CDK90.28104980
128DAPK30.27103211
129TESK10.25064152
130MST1R0.22677091
131STK240.22435855
132PRKDC0.22318934
133CSNK1G20.19607223
134ARAF0.19595143
135INSRR0.18870703
136AKT20.17913975

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.33876263
2DNA replication_Homo sapiens_hsa030304.26966630
3Mismatch repair_Homo sapiens_hsa034303.86662147
4RNA polymerase_Homo sapiens_hsa030203.51186630
5Proteasome_Homo sapiens_hsa030503.30894961
6Homologous recombination_Homo sapiens_hsa034403.23907245
7Protein export_Homo sapiens_hsa030603.05968248
8Oxidative phosphorylation_Homo sapiens_hsa001902.76612840
9Nucleotide excision repair_Homo sapiens_hsa034202.72261897
10Spliceosome_Homo sapiens_hsa030402.71984399
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61339817
12Fanconi anemia pathway_Homo sapiens_hsa034602.49036786
13Pyrimidine metabolism_Homo sapiens_hsa002402.47956305
14Parkinsons disease_Homo sapiens_hsa050122.42806070
15Non-homologous end-joining_Homo sapiens_hsa034502.37783942
16Base excision repair_Homo sapiens_hsa034102.31937536
17Basal transcription factors_Homo sapiens_hsa030221.99642431
18Huntingtons disease_Homo sapiens_hsa050161.96673105
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.93333456
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92160556
21RNA transport_Homo sapiens_hsa030131.89365192
22Cell cycle_Homo sapiens_hsa041101.86627640
23RNA degradation_Homo sapiens_hsa030181.85459283
24One carbon pool by folate_Homo sapiens_hsa006701.77349756
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66551947
26Alzheimers disease_Homo sapiens_hsa050101.58444608
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53426838
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49971977
29* Purine metabolism_Homo sapiens_hsa002301.46328335
30Pyruvate metabolism_Homo sapiens_hsa006201.38710493
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27695275
32Arachidonic acid metabolism_Homo sapiens_hsa005901.18031548
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17927046
34Propanoate metabolism_Homo sapiens_hsa006401.17276953
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12976747
36Biosynthesis of amino acids_Homo sapiens_hsa012301.09704646
37Ether lipid metabolism_Homo sapiens_hsa005651.09571504
38Fatty acid elongation_Homo sapiens_hsa000621.07569671
39Carbon metabolism_Homo sapiens_hsa012000.99671826
40Systemic lupus erythematosus_Homo sapiens_hsa053220.98704290
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96763126
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96651288
43mRNA surveillance pathway_Homo sapiens_hsa030150.93214059
44Linoleic acid metabolism_Homo sapiens_hsa005910.92814144
45Glutathione metabolism_Homo sapiens_hsa004800.92660946
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87608931
47p53 signaling pathway_Homo sapiens_hsa041150.87194209
48Selenocompound metabolism_Homo sapiens_hsa004500.84155562
49Sphingolipid metabolism_Homo sapiens_hsa006000.79883425
50Epstein-Barr virus infection_Homo sapiens_hsa051690.76894768
51Steroid biosynthesis_Homo sapiens_hsa001000.75132391
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75114702
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70553137
54Phototransduction_Homo sapiens_hsa047440.69661676
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66273706
56Metabolic pathways_Homo sapiens_hsa011000.61711587
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60886445
58Peroxisome_Homo sapiens_hsa041460.59918857
59Folate biosynthesis_Homo sapiens_hsa007900.58533990
60Autoimmune thyroid disease_Homo sapiens_hsa053200.57535575
61Cardiac muscle contraction_Homo sapiens_hsa042600.55868920
62Vitamin B6 metabolism_Homo sapiens_hsa007500.53974697
63Allograft rejection_Homo sapiens_hsa053300.50014842
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48510090
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45179711
66Asthma_Homo sapiens_hsa053100.45093927
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44695486
68Alcoholism_Homo sapiens_hsa050340.44199606
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43236813
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42769743
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37749152
72Chemical carcinogenesis_Homo sapiens_hsa052040.37633092
73Viral carcinogenesis_Homo sapiens_hsa052030.36400128
74Butanoate metabolism_Homo sapiens_hsa006500.35787861
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35502150
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35405641
77Caffeine metabolism_Homo sapiens_hsa002320.35024011
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34852446
79Fatty acid degradation_Homo sapiens_hsa000710.34716577
80Galactose metabolism_Homo sapiens_hsa000520.33973638
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.32974408
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32749141
83Graft-versus-host disease_Homo sapiens_hsa053320.32591288
84Herpes simplex infection_Homo sapiens_hsa051680.32384720
85Oocyte meiosis_Homo sapiens_hsa041140.32355796
86Fatty acid metabolism_Homo sapiens_hsa012120.32349723
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32186952
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32075650
89Retinol metabolism_Homo sapiens_hsa008300.31174418
90Arginine and proline metabolism_Homo sapiens_hsa003300.30709220
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30337011
92Hematopoietic cell lineage_Homo sapiens_hsa046400.30335808
93Vibrio cholerae infection_Homo sapiens_hsa051100.28745339
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.27412850
95Primary immunodeficiency_Homo sapiens_hsa053400.26037062
96beta-Alanine metabolism_Homo sapiens_hsa004100.25997091
97Regulation of autophagy_Homo sapiens_hsa041400.24851463
98Serotonergic synapse_Homo sapiens_hsa047260.23176614
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.23092986
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22752569
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22700333
102Tyrosine metabolism_Homo sapiens_hsa003500.21963646
103Tryptophan metabolism_Homo sapiens_hsa003800.21449395
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20641443
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.20434528
106Arginine biosynthesis_Homo sapiens_hsa002200.20304134
107Sulfur metabolism_Homo sapiens_hsa009200.19064975
108Other glycan degradation_Homo sapiens_hsa005110.18179386
109Phenylalanine metabolism_Homo sapiens_hsa003600.16793648
110N-Glycan biosynthesis_Homo sapiens_hsa005100.16407809
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15989901
112HTLV-I infection_Homo sapiens_hsa051660.15970233
113Histidine metabolism_Homo sapiens_hsa003400.15881292
114Basal cell carcinoma_Homo sapiens_hsa052170.14365820
115Thyroid cancer_Homo sapiens_hsa052160.14154647
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.13677204
117TGF-beta signaling pathway_Homo sapiens_hsa043500.13552961
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.13376345
119Rheumatoid arthritis_Homo sapiens_hsa053230.11973939
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.11735667
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.10811177
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.10705276
123Phagosome_Homo sapiens_hsa041450.10413566
124Sulfur relay system_Homo sapiens_hsa041220.09841015
125Vitamin digestion and absorption_Homo sapiens_hsa049770.09840856
126Collecting duct acid secretion_Homo sapiens_hsa049660.09093377
127Fructose and mannose metabolism_Homo sapiens_hsa000510.08891058
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.08418543
129MicroRNAs in cancer_Homo sapiens_hsa052060.08143521
130Hedgehog signaling pathway_Homo sapiens_hsa043400.07439375
131Maturity onset diabetes of the young_Homo sapiens_hsa049500.07201245
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.07027676
133Pentose phosphate pathway_Homo sapiens_hsa000300.06901283
134Renin-angiotensin system_Homo sapiens_hsa046140.06026520

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