NUDT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.80184339
2viral transcription (GO:0019083)4.94955528
3DNA deamination (GO:0045006)4.78880419
4translational termination (GO:0006415)4.74962170
5ribosomal small subunit biogenesis (GO:0042274)4.46111355
6behavioral response to nicotine (GO:0035095)4.41973963
7maturation of SSU-rRNA (GO:0030490)4.26725684
8translational elongation (GO:0006414)4.25392527
9water-soluble vitamin biosynthetic process (GO:0042364)4.24311721
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.14058192
11cotranslational protein targeting to membrane (GO:0006613)4.04416820
12protein targeting to ER (GO:0045047)4.02017115
13protein localization to endoplasmic reticulum (GO:0070972)3.85864056
14metallo-sulfur cluster assembly (GO:0031163)3.83264728
15iron-sulfur cluster assembly (GO:0016226)3.83264728
16establishment of protein localization to endoplasmic reticulum (GO:0072599)3.82968064
17viral life cycle (GO:0019058)3.68657166
18ribosomal large subunit biogenesis (GO:0042273)3.61265290
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.57879853
20cellular protein complex disassembly (GO:0043624)3.51189886
21translational initiation (GO:0006413)3.47739863
22lysine catabolic process (GO:0006554)3.37680425
23lysine metabolic process (GO:0006553)3.37680425
24pseudouridine synthesis (GO:0001522)3.34132415
25piRNA metabolic process (GO:0034587)3.32980510
26platelet dense granule organization (GO:0060155)3.30657560
27indolalkylamine metabolic process (GO:0006586)3.27393682
28L-fucose catabolic process (GO:0042355)3.27371276
29fucose catabolic process (GO:0019317)3.27371276
30L-fucose metabolic process (GO:0042354)3.27371276
31respiratory chain complex IV assembly (GO:0008535)3.22679484
32kynurenine metabolic process (GO:0070189)3.22646040
33ribonucleoprotein complex biogenesis (GO:0022613)3.19684117
34proteasome assembly (GO:0043248)3.19463587
35protein polyglutamylation (GO:0018095)3.18590239
36tryptophan catabolic process (GO:0006569)3.15854934
37indole-containing compound catabolic process (GO:0042436)3.15854934
38indolalkylamine catabolic process (GO:0046218)3.15854934
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.11204116
40response to pheromone (GO:0019236)3.11096400
41oxidative phosphorylation (GO:0006119)3.09832297
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.07548373
43antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.06252024
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.06252024
45regulation of respiratory burst (GO:0060263)3.05066600
46cellular ketone body metabolic process (GO:0046950)3.04149890
47nonmotile primary cilium assembly (GO:0035058)3.02285769
48preassembly of GPI anchor in ER membrane (GO:0016254)3.02176622
49protein complex disassembly (GO:0043241)3.01444201
50mitochondrial DNA replication (GO:0006264)3.00778876
51DNA methylation involved in gamete generation (GO:0043046)3.00110255
52glycine metabolic process (GO:0006544)2.99799685
53response to interferon-beta (GO:0035456)2.99795159
54translation (GO:0006412)2.98468031
55fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.98210998
56GPI anchor metabolic process (GO:0006505)2.98101016
57replication fork processing (GO:0031297)2.93243184
58mannosylation (GO:0097502)2.90894694
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89778064
60protein K6-linked ubiquitination (GO:0085020)2.89091866
61mitochondrial RNA metabolic process (GO:0000959)2.88472295
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88354735
63cellular component biogenesis (GO:0044085)2.88170079
64L-phenylalanine metabolic process (GO:0006558)2.86856384
65erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.86856384
66telomere maintenance via semi-conservative replication (GO:0032201)2.86191599
67cell proliferation in forebrain (GO:0021846)2.86011523
68macromolecular complex disassembly (GO:0032984)2.84732926
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.84299652
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.84299652
71negative regulation of telomere maintenance (GO:0032205)2.83969421
72tryptophan metabolic process (GO:0006568)2.83616064
73branched-chain amino acid catabolic process (GO:0009083)2.83548537
74IMP metabolic process (GO:0046040)2.83097273
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.82999602
76RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.81756877
77valine metabolic process (GO:0006573)2.81542438
78protein-cofactor linkage (GO:0018065)2.80714322
79ketone body metabolic process (GO:1902224)2.80559892
80detection of light stimulus involved in visual perception (GO:0050908)2.80026141
81detection of light stimulus involved in sensory perception (GO:0050962)2.80026141
82axoneme assembly (GO:0035082)2.77546004
83intraciliary transport (GO:0042073)2.77537396
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.76862330
85male meiosis I (GO:0007141)2.76322089
86ethanol oxidation (GO:0006069)2.75990010
87ATP synthesis coupled proton transport (GO:0015986)2.75795990
88energy coupled proton transport, down electrochemical gradient (GO:0015985)2.75795990
89nuclear-transcribed mRNA catabolic process (GO:0000956)2.75224069
90fatty acid beta-oxidation (GO:0006635)2.74495810
91sulfation (GO:0051923)2.73359921
92branched-chain amino acid metabolic process (GO:0009081)2.72029390
93respiratory electron transport chain (GO:0022904)2.71442396
94mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.71128956
95regulation of nuclear cell cycle DNA replication (GO:0033262)2.71033752
96epithelial cilium movement (GO:0003351)2.70920117
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.69578445
98gamma-aminobutyric acid transport (GO:0015812)2.68121782
99cilium morphogenesis (GO:0060271)2.68117972
100reciprocal meiotic recombination (GO:0007131)2.67827441
101reciprocal DNA recombination (GO:0035825)2.67827441
102glyoxylate metabolic process (GO:0046487)2.67763615
103DNA strand elongation involved in DNA replication (GO:0006271)2.67537783
104transcription elongation from RNA polymerase III promoter (GO:0006385)2.66865389
105termination of RNA polymerase III transcription (GO:0006386)2.66865389
106pteridine-containing compound biosynthetic process (GO:0042559)2.66673892
107cysteine metabolic process (GO:0006534)2.66583760
1082-oxoglutarate metabolic process (GO:0006103)2.66503166
109mRNA catabolic process (GO:0006402)2.66334654
110negative regulation of transcription regulatory region DNA binding (GO:2000678)2.66103352
111centriole replication (GO:0007099)2.66073569
112nucleobase biosynthetic process (GO:0046112)2.64763316
113peptidyl-histidine modification (GO:0018202)2.64193937
114recombinational repair (GO:0000725)2.64110252
115negative regulation of response to food (GO:0032096)2.64064529
116negative regulation of appetite (GO:0032099)2.64064529
117quinone biosynthetic process (GO:1901663)2.64035598
118ubiquinone biosynthetic process (GO:0006744)2.64035598
119positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.63977195
120electron transport chain (GO:0022900)2.63269284
121synapsis (GO:0007129)2.63203680
122cilium organization (GO:0044782)2.62727147
123regulation of mitochondrial translation (GO:0070129)2.62352529
124ribosome biogenesis (GO:0042254)2.61454295
125L-phenylalanine catabolic process (GO:0006559)2.61435746
126erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.61435746
127disruption of cells of other organism (GO:0044364)2.60724014
128killing of cells of other organism (GO:0031640)2.60724014
129oxaloacetate metabolic process (GO:0006107)2.60394176
130protein targeting to membrane (GO:0006612)2.60392085
131positive regulation of respiratory burst (GO:0060267)2.60376138
132tricarboxylic acid cycle (GO:0006099)2.60104094
133cytochrome complex assembly (GO:0017004)2.59920873
134double-strand break repair via homologous recombination (GO:0000724)2.59864706
135aerobic respiration (GO:0009060)2.59636823
136mitochondrial respiratory chain complex I assembly (GO:0032981)2.58872360
137NADH dehydrogenase complex assembly (GO:0010257)2.58872360
138mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58872360
139somite development (GO:0061053)2.57958262
140rRNA processing (GO:0006364)2.57273258
141pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.57208618
142mitochondrial respiratory chain complex assembly (GO:0033108)2.57144740
143somatic hypermutation of immunoglobulin genes (GO:0016446)2.57043318
144somatic diversification of immune receptors via somatic mutation (GO:0002566)2.57043318
145protein complex biogenesis (GO:0070271)2.56343302
146RNA catabolic process (GO:0006401)2.56127656
147DNA strand elongation (GO:0022616)2.55849098
148tRNA processing (GO:0008033)2.55571340
149regulation of cilium movement (GO:0003352)2.55360093
150amino acid salvage (GO:0043102)2.54324562
151L-methionine salvage (GO:0071267)2.54324562
152DNA double-strand break processing (GO:0000729)2.54283237
153purine-containing compound salvage (GO:0043101)2.53853463
154deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.53641936
155tricarboxylic acid metabolic process (GO:0072350)2.53295582
156indole-containing compound metabolic process (GO:0042430)2.52365852
157regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.52034092
158cilium assembly (GO:0042384)2.51829881
159positive regulation of gamma-delta T cell activation (GO:0046645)2.51828948
160negative regulation of DNA-dependent DNA replication (GO:2000104)2.51387581
161serine family amino acid metabolic process (GO:0009069)2.49458197
162photoreceptor cell maintenance (GO:0045494)2.49316073
163aromatic amino acid family catabolic process (GO:0009074)2.48295670
164amino-acid betaine metabolic process (GO:0006577)2.47563941
165antigen processing and presentation of endogenous antigen (GO:0019883)2.47284506
166regulation of meiosis I (GO:0060631)2.47148076
167resolution of meiotic recombination intermediates (GO:0000712)2.46506195
168DNA unwinding involved in DNA replication (GO:0006268)2.46012702
169fatty acid catabolic process (GO:0009062)2.45556301
170serine family amino acid catabolic process (GO:0009071)2.45520437
171rRNA metabolic process (GO:0016072)2.45288284
172folic acid metabolic process (GO:0046655)2.44957579
173IMP biosynthetic process (GO:0006188)2.44117535
174retinal cone cell development (GO:0046549)2.42832912
175protein neddylation (GO:0045116)2.42227932
176L-methionine biosynthetic process (GO:0071265)2.42044521
177maturation of 5.8S rRNA (GO:0000460)2.41776092
178S-adenosylmethionine metabolic process (GO:0046500)2.39263275
179chaperone-mediated protein transport (GO:0072321)2.38800525
180purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.38798450
1813-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.38798450
182regulation of mitotic spindle checkpoint (GO:1903504)2.36685667
183regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.36685667

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.73812957
2ZNF274_21170338_ChIP-Seq_K562_Hela3.56187096
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.54763315
4E2F7_22180533_ChIP-Seq_HELA_Human3.54044524
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.45866795
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.96594566
7VDR_22108803_ChIP-Seq_LS180_Human2.81511685
8GBX2_23144817_ChIP-Seq_PC3_Human2.79869023
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.71018712
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68080282
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59478514
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.54996510
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53895671
14IGF1R_20145208_ChIP-Seq_DFB_Human2.53452153
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.49009699
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48099430
17FUS_26573619_Chip-Seq_HEK293_Human2.47727145
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47330878
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.42674402
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.38330130
21* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36104724
22EWS_26573619_Chip-Seq_HEK293_Human2.32969372
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31902545
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31813683
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.31419379
26TAF15_26573619_Chip-Seq_HEK293_Human2.30092072
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24143472
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.16745805
29RXR_22158963_ChIP-Seq_LIVER_Mouse2.13702162
30IRF8_22096565_ChIP-ChIP_GC-B_Human2.12325813
31PPARA_22158963_ChIP-Seq_LIVER_Mouse2.10661760
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.10548166
33FLI1_27457419_Chip-Seq_LIVER_Mouse2.05919717
34* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02417436
35* SRF_21415370_ChIP-Seq_HL-1_Mouse2.01879981
36CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01777942
37VDR_23849224_ChIP-Seq_CD4+_Human2.00038149
38P300_19829295_ChIP-Seq_ESCs_Human1.99346412
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.99182399
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.98555396
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96010138
42IRF1_19129219_ChIP-ChIP_H3396_Human1.94745370
43* FOXP3_21729870_ChIP-Seq_TREG_Human1.94432394
44ELK1_19687146_ChIP-ChIP_HELA_Human1.93876097
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93370018
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.92141737
47SCL_19346495_ChIP-Seq_HPC-7_Human1.91614544
48* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90211998
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90078055
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89834815
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.87905657
52DCP1A_22483619_ChIP-Seq_HELA_Human1.85913971
53XRN2_22483619_ChIP-Seq_HELA_Human1.85785022
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84819235
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81259759
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80641098
57EZH2_22144423_ChIP-Seq_EOC_Human1.80265216
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.79167895
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.78940508
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78079428
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.77731323
62ER_23166858_ChIP-Seq_MCF-7_Human1.77468619
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77009030
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.74823263
65CIITA_25753668_ChIP-Seq_RAJI_Human1.72334046
66GATA1_22025678_ChIP-Seq_K562_Human1.71293868
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70958608
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70780805
69* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70658047
70MYC_22102868_ChIP-Seq_BL_Human1.70445994
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65935045
72VDR_21846776_ChIP-Seq_THP-1_Human1.65156627
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64706725
74E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64705480
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61552645
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61529691
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58479956
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58363554
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55513359
80* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53261588
81GABP_19822575_ChIP-Seq_HepG2_Human1.52420439
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50429993
83TP53_22573176_ChIP-Seq_HFKS_Human1.49791274
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47961378
85SPI1_23547873_ChIP-Seq_NB4_Human1.45101409
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44663092
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42501658
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41094950
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.40624834
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40359832
91CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39516771
92SMAD4_21799915_ChIP-Seq_A2780_Human1.38444460
93STAT3_23295773_ChIP-Seq_U87_Human1.38276338
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36986004
95TTF2_22483619_ChIP-Seq_HELA_Human1.36924166
96* NANOG_19829295_ChIP-Seq_ESCs_Human1.36284938
97* SOX2_19829295_ChIP-Seq_ESCs_Human1.36284938
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35862703
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34783126
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33347371
101CBP_20019798_ChIP-Seq_JUKART_Human1.33347371
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31938009
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31769014
104BCAT_22108803_ChIP-Seq_LS180_Human1.31446538
105FOXA1_25329375_ChIP-Seq_VCAP_Human1.30984096
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30984096
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29723319
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.29377607
109STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29237272
110TCF4_23295773_ChIP-Seq_U87_Human1.29235549
111GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29015131
112* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26152244
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24062874
114AR_25329375_ChIP-Seq_VCAP_Human1.23836816
115EZH2_27294783_Chip-Seq_NPCs_Mouse1.23579845
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22937081
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22150464
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.20046200
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19844245
120GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18525216
121TCF4_22108803_ChIP-Seq_LS180_Human1.18180649
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17594594
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17593198
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16975301
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16845486
126POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16239931
127STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15349308
128TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14255747
129NCOR_22424771_ChIP-Seq_293T_Human1.13809814
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13770790
131TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13254629
132LXR_22158963_ChIP-Seq_LIVER_Mouse1.12538268
133FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12401097
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11915990
135PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11436986
136RUNX1_22412390_ChIP-Seq_EML_Mouse1.11123950
137PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11079837
138GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10453821
139PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10094516
140CBX2_27304074_Chip-Seq_ESCs_Mouse1.09527434
141BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09461696
142GATA3_21878914_ChIP-Seq_MCF-7_Human1.08897691
143AR_20517297_ChIP-Seq_VCAP_Human1.08152288
144AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07595566
145GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07394815
146E2F1_21310950_ChIP-Seq_MCF-7_Human1.07361741
147SMAD3_21741376_ChIP-Seq_EPCs_Human1.07011251
148RNF2_27304074_Chip-Seq_NSC_Mouse1.06911976
149TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06602776
150MYB_26560356_Chip-Seq_TH1_Human1.05317044
151NANOG_18555785_Chip-Seq_ESCs_Mouse1.04590369
152MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03911316
153CRX_20693478_ChIP-Seq_RETINA_Mouse1.02658182
154FLI1_21867929_ChIP-Seq_TH2_Mouse1.02592883
155POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02015865
156TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02015865
157LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01917084
158MAF_26560356_Chip-Seq_TH1_Human1.01854609
159MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01435671
160EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00512608
161MYC_18940864_ChIP-ChIP_HL60_Human1.00397015
162NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00361640
163RUNX2_22187159_ChIP-Seq_PCA_Human1.00278791
164MYB_26560356_Chip-Seq_TH2_Human1.00127992
165UTX_26944678_Chip-Seq_JUKART_Human1.00047509
166CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99628777
167* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99360139
168OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99188113
169RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99118703
170SMAD4_21741376_ChIP-Seq_EPCs_Human0.97735235
171TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97466386
172CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97199425
173VDR_24763502_ChIP-Seq_THP-1_Human0.97030331
174CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95912956
175MAF_26560356_Chip-Seq_TH2_Human0.95583251
176BP1_19119308_ChIP-ChIP_Hs578T_Human0.95581193
177SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95048358
178ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94501929
179BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94280875
180FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94180062
181MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92928478

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.72276325
2MP0005360_urolithiasis3.69759927
3MP0003806_abnormal_nucleotide_metabolis3.40776848
4MP0003195_calcinosis3.28466561
5MP0009840_abnormal_foam_cell3.01314484
6MP0008877_abnormal_DNA_methylation2.88578389
7MP0005085_abnormal_gallbladder_physiolo2.83847858
8MP0002396_abnormal_hematopoietic_system2.77581614
9MP0005365_abnormal_bile_salt2.73784788
10MP0000569_abnormal_digit_pigmentation2.71542949
11MP0003136_yellow_coat_color2.50714944
12MP0009379_abnormal_foot_pigmentation2.49918410
13MP0003646_muscle_fatigue2.49457004
14MP0002102_abnormal_ear_morphology2.45957730
15MP0006292_abnormal_olfactory_placode2.44496821
16MP0006036_abnormal_mitochondrial_physio2.44458274
17MP0000372_irregular_coat_pigmentation2.36209463
18MP0006072_abnormal_retinal_apoptosis2.35304724
19MP0005551_abnormal_eye_electrophysiolog2.33851486
20MP0002938_white_spotting2.15624953
21MP0003763_abnormal_thymus_physiology2.14270743
22MP0001835_abnormal_antigen_presentation2.07226269
23MP0008875_abnormal_xenobiotic_pharmacok2.02982704
24MP0005646_abnormal_pituitary_gland2.00971425
25MP0003656_abnormal_erythrocyte_physiolo2.00444183
26MP0003186_abnormal_redox_activity1.97587209
27MP0005671_abnormal_response_to1.88673573
28MP0002166_altered_tumor_susceptibility1.86195536
29MP0003693_abnormal_embryo_hatching1.85161313
30MP0003718_maternal_effect1.76134963
31MP0001485_abnormal_pinna_reflex1.76113856
32MP0004145_abnormal_muscle_electrophysio1.76108473
33MP0002736_abnormal_nociception_after1.74602384
34MP0001968_abnormal_touch/_nociception1.74452245
35MP0003724_increased_susceptibility_to1.74322522
36MP0001853_heart_inflammation1.74158305
37MP0005253_abnormal_eye_physiology1.73304046
38MP0004808_abnormal_hematopoietic_stem1.70986616
39MP0009046_muscle_twitch1.69635107
40MP0005084_abnormal_gallbladder_morpholo1.69597631
41MP0002653_abnormal_ependyma_morphology1.66276309
42MP0000427_abnormal_hair_cycle1.65524547
43MP0002160_abnormal_reproductive_system1.64948629
44MP0003191_abnormal_cellular_cholesterol1.60349231
45MP0000490_abnormal_crypts_of1.59568925
46MP0008872_abnormal_physiological_respon1.57449214
47MP0004142_abnormal_muscle_tone1.55679747
48MP0005330_cardiomyopathy1.54816361
49MP0000685_abnormal_immune_system1.54439656
50MP0009785_altered_susceptibility_to1.53391302
51MP0003787_abnormal_imprinting1.53251068
52MP0004133_heterotaxia1.47840234
53MP0001986_abnormal_taste_sensitivity1.47668467
54MP0005319_abnormal_enzyme/_coenzyme1.47383650
55MP0000631_abnormal_neuroendocrine_gland1.47170890
56MP0002398_abnormal_bone_marrow1.45682982
57MP0005025_abnormal_response_to1.45526412
58MP0002638_abnormal_pupillary_reflex1.44815117
59MP0002837_dystrophic_cardiac_calcinosis1.44436401
60MP0001800_abnormal_humoral_immune1.43756340
61MP0005332_abnormal_amino_acid1.43340711
62MP0002876_abnormal_thyroid_physiology1.42444164
63MP0005464_abnormal_platelet_physiology1.41855812
64MP0006276_abnormal_autonomic_nervous1.41175355
65MP0001764_abnormal_homeostasis1.41080557
66MP0010094_abnormal_chromosome_stability1.39133241
67MP0001545_abnormal_hematopoietic_system1.36969684
68MP0005397_hematopoietic_system_phenotyp1.36969684
69MP0002272_abnormal_nervous_system1.36674478
70MP0000689_abnormal_spleen_morphology1.36627598
71MP0002006_tumorigenesis1.36303611
72MP0003890_abnormal_embryonic-extraembry1.35849012
73MP0005171_absent_coat_pigmentation1.35089244
74MP0003252_abnormal_bile_duct1.33898171
75MP0008058_abnormal_DNA_repair1.33752462
76MP0009333_abnormal_splenocyte_physiolog1.33268119
77MP0000609_abnormal_liver_physiology1.31910828
78MP0003436_decreased_susceptibility_to1.31665478
79MP0001873_stomach_inflammation1.31225692
80MP0005075_abnormal_melanosome_morpholog1.30728801
81MP0005584_abnormal_enzyme/coenzyme_acti1.30696084
82MP0008469_abnormal_protein_level1.30649303
83MP0005174_abnormal_tail_pigmentation1.30444473
84MP0004885_abnormal_endolymph1.30286155
85MP0001529_abnormal_vocalization1.30059398
86MP0010329_abnormal_lipoprotein_level1.29298053
87MP0004957_abnormal_blastocyst_morpholog1.29212568
88MP0010155_abnormal_intestine_physiology1.28684940
89MP0000749_muscle_degeneration1.28328048
90MP0002722_abnormal_immune_system1.27274904
91MP0001501_abnormal_sleep_pattern1.26845989
92MP0005389_reproductive_system_phenotype1.26361459
93MP0003880_abnormal_central_pattern1.26118354
94MP0009745_abnormal_behavioral_response1.25906840
95MP0005670_abnormal_white_adipose1.25764414
96MP0002723_abnormal_immune_serum1.25357980
97MP0005083_abnormal_biliary_tract1.24776636
98MP0000716_abnormal_immune_system1.23505818
99MP0003077_abnormal_cell_cycle1.22813902
100MP0006035_abnormal_mitochondrial_morpho1.21501486
101MP0002420_abnormal_adaptive_immunity1.20656739
102MP0002429_abnormal_blood_cell1.19912250
103MP0003221_abnormal_cardiomyocyte_apopto1.18195081
104MP0001819_abnormal_immune_cell1.17747125
105MP0008789_abnormal_olfactory_epithelium1.17119961
106MP0002452_abnormal_antigen_presenting1.14732820
107MP0009763_increased_sensitivity_to1.14675808
108MP0001293_anophthalmia1.13532934
109MP0000465_gastrointestinal_hemorrhage1.13281278
110MP0004147_increased_porphyrin_level1.12744302
111MP0003121_genomic_imprinting1.12179303
112MP0010368_abnormal_lymphatic_system1.11909058
113MP0001984_abnormal_olfaction1.11187892
114MP0005000_abnormal_immune_tolerance1.10769713
115MP0004043_abnormal_pH_regulation1.10572875
116MP0004084_abnormal_cardiac_muscle1.09368299
117MP0003937_abnormal_limbs/digits/tail_de1.08777466
118MP0001486_abnormal_startle_reflex1.08776941
119MP0009697_abnormal_copulation1.08715750
120MP0002928_abnormal_bile_duct1.08335786
121MP0009643_abnormal_urine_homeostasis1.06752557
122MP0003866_abnormal_defecation1.02829227
123MP0001845_abnormal_inflammatory_respons1.02546768
124MP0001666_abnormal_nutrient_absorption1.02137556
125MP0004215_abnormal_myocardial_fiber1.01512352
126MP0002132_abnormal_respiratory_system1.00888835
127MP0002405_respiratory_system_inflammati1.00355283
128MP0000598_abnormal_liver_morphology1.00350619
129MP0002419_abnormal_innate_immunity0.99296511
130MP0000703_abnormal_thymus_morphology0.97978826
131MP0002138_abnormal_hepatobiliary_system0.97537328
132MP0008007_abnormal_cellular_replicative0.96607824
133MP0005645_abnormal_hypothalamus_physiol0.95659430
134MP0002019_abnormal_tumor_incidence0.95504149
135MP0003137_abnormal_impulse_conducting0.95448405
136MP0005266_abnormal_metabolism0.95346089
137MP0006054_spinal_hemorrhage0.95166646
138MP0008995_early_reproductive_senescence0.95150529
139MP0000343_altered_response_to0.94760283
140MP0002148_abnormal_hypersensitivity_rea0.94671209
141MP0002557_abnormal_social/conspecific_i0.94515324
142MP0005195_abnormal_posterior_eye0.94397688
143MP0002163_abnormal_gland_morphology0.92606300
144MP0001929_abnormal_gametogenesis0.92060659
145MP0002751_abnormal_autonomic_nervous0.91863526
146MP0002277_abnormal_respiratory_mucosa0.91528578
147MP0004036_abnormal_muscle_relaxation0.90292776
148MP0002095_abnormal_skin_pigmentation0.89725589
149MP0005636_abnormal_mineral_homeostasis0.89658079
150MP0000049_abnormal_middle_ear0.88187074
151MP0002118_abnormal_lipid_homeostasis0.87712297
152MP0009764_decreased_sensitivity_to0.85854004
153MP0005379_endocrine/exocrine_gland_phen0.85737022
154MP0008775_abnormal_heart_ventricle0.85281972
155MP0002210_abnormal_sex_determination0.84883299
156MP0000751_myopathy0.84449173
157MP0004742_abnormal_vestibular_system0.84395505
158MP0002282_abnormal_trachea_morphology0.84045159
159MP0003786_premature_aging0.82930474
160MP0003011_delayed_dark_adaptation0.82821721
161MP0008057_abnormal_DNA_replication0.82400569
162MP0001324_abnormal_eye_pigmentation0.81776182
163MP0003868_abnormal_feces_composition0.81350577
164MP0001790_abnormal_immune_system0.81064870
165MP0002067_abnormal_sensory_capabilities0.80906054
166MP0000653_abnormal_sex_gland0.80773816
167MP0003698_abnormal_male_reproductive0.79317000
168MP0010386_abnormal_urinary_bladder0.79197296
169MP0002733_abnormal_thermal_nociception0.78950983
170MP0002572_abnormal_emotion/affect_behav0.78033221
171MP0001145_abnormal_male_reproductive0.77839605
172MP0001963_abnormal_hearing_physiology0.77416722
173MP0005410_abnormal_fertilization0.77414449
174MP0002234_abnormal_pharynx_morphology0.76662582
175MP0002064_seizures0.76012055
176MP0003119_abnormal_digestive_system0.75566830
177MP0005386_behavior/neurological_phenoty0.75130439
178MP0004924_abnormal_behavior0.75130439
179MP0002735_abnormal_chemical_nociception0.74794024

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.39244040
2Abnormality of cells of the erythroid lineage (HP:0012130)5.16395284
3Hepatic necrosis (HP:0002605)4.83317453
4Hepatocellular necrosis (HP:0001404)4.74373711
5Pancreatic cysts (HP:0001737)4.48643214
6Pancreatic fibrosis (HP:0100732)4.32596835
7True hermaphroditism (HP:0010459)4.24690153
8Increased muscle lipid content (HP:0009058)4.08774533
9Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.06058592
10Increased intramyocellular lipid droplets (HP:0012240)4.04740690
11Molar tooth sign on MRI (HP:0002419)4.03268685
12Abnormality of midbrain morphology (HP:0002418)4.03268685
13Thrombocytosis (HP:0001894)3.95618590
14Nephronophthisis (HP:0000090)3.69154101
15Lipid accumulation in hepatocytes (HP:0006561)3.65697189
16Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.53047078
17Mitochondrial inheritance (HP:0001427)3.52345656
18Increased hepatocellular lipid droplets (HP:0006565)3.47407023
19Abnormality of fatty-acid metabolism (HP:0004359)3.45097255
20Reticulocytopenia (HP:0001896)3.44426974
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.41945389
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.41945389
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.40703172
24Increased CSF lactate (HP:0002490)3.38567970
25Increased serum lactate (HP:0002151)3.35439929
26Abnormality of the renal cortex (HP:0011035)3.24903450
27Abnormality of aromatic amino acid family metabolism (HP:0004338)3.24153433
28Progressive muscle weakness (HP:0003323)3.19315651
29Medial flaring of the eyebrow (HP:0010747)3.18605692
30Lactic acidosis (HP:0003128)3.18434063
31Congenital stationary night blindness (HP:0007642)3.15275615
32Abnormality of the renal medulla (HP:0100957)3.11371495
33Reduced antithrombin III activity (HP:0001976)2.98601264
34Type II lissencephaly (HP:0007260)2.97827249
35Ragged-red muscle fibers (HP:0003200)2.97671732
36Abnormal mitochondria in muscle tissue (HP:0008316)2.92487964
37Dicarboxylic aciduria (HP:0003215)2.92182043
38Abnormality of dicarboxylic acid metabolism (HP:0010995)2.92182043
39Prolonged partial thromboplastin time (HP:0003645)2.91269742
40Methylmalonic acidemia (HP:0002912)2.89359004
41Cerebral edema (HP:0002181)2.89008612
42Acute encephalopathy (HP:0006846)2.86578746
43Generalized aminoaciduria (HP:0002909)2.80907269
44Exertional dyspnea (HP:0002875)2.77218100
45Respiratory difficulties (HP:0002880)2.76835946
46Abnormality of the heme biosynthetic pathway (HP:0010472)2.74358191
47Acute necrotizing encephalopathy (HP:0006965)2.73940611
48Renal Fanconi syndrome (HP:0001994)2.73717259
49Cystic liver disease (HP:0006706)2.72323025
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.70449554
51Macrocytic anemia (HP:0001972)2.68303171
52Pallor (HP:0000980)2.67351595
53Ketosis (HP:0001946)2.66675323
54Hyperammonemia (HP:0001987)2.60910985
55Intrahepatic cholestasis (HP:0001406)2.58590319
56Pendular nystagmus (HP:0012043)2.54300167
57Aplastic anemia (HP:0001915)2.52915562
58Congenital primary aphakia (HP:0007707)2.52867208
59Microcytic anemia (HP:0001935)2.52220033
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.51985463
61Abnormality of monocarboxylic acid metabolism (HP:0010996)2.51826377
62IgM deficiency (HP:0002850)2.51502021
63Exercise intolerance (HP:0003546)2.51204919
64Type I transferrin isoform profile (HP:0003642)2.50725362
65Gait imbalance (HP:0002141)2.49747001
66Increased serum ferritin (HP:0003281)2.49085193
67Abolished electroretinogram (ERG) (HP:0000550)2.48807547
68Methylmalonic aciduria (HP:0012120)2.47911985
69Tubular atrophy (HP:0000092)2.46314158
70Rhabdomyolysis (HP:0003201)2.46251521
71Congenital, generalized hypertrichosis (HP:0004540)2.45593627
72Nephrogenic diabetes insipidus (HP:0009806)2.44062007
73Sclerocornea (HP:0000647)2.43947840
74Lethargy (HP:0001254)2.43024148
75Chronic hepatic failure (HP:0100626)2.42198467
76Hypoglycemic coma (HP:0001325)2.40870056
77Multiple enchondromatosis (HP:0005701)2.38913990
78Hyperglycinuria (HP:0003108)2.38787179
79Short tibia (HP:0005736)2.37860572
80Gaze-evoked nystagmus (HP:0000640)2.37571521
81Glycosuria (HP:0003076)2.34760553
82Abnormality of urine glucose concentration (HP:0011016)2.34760553
83Hypobetalipoproteinemia (HP:0003563)2.33498800
84CNS demyelination (HP:0007305)2.28877009
85Bile duct proliferation (HP:0001408)2.27451083
86Abnormal biliary tract physiology (HP:0012439)2.27451083
87Furrowed tongue (HP:0000221)2.27365977
88Myoglobinuria (HP:0002913)2.27312691
89Hyperbilirubinemia (HP:0002904)2.25544150
90Attenuation of retinal blood vessels (HP:0007843)2.24647573
91Anencephaly (HP:0002323)2.24579380
92Elevated erythrocyte sedimentation rate (HP:0003565)2.24536562
93Respiratory failure (HP:0002878)2.21289397
94Abnormality of iron homeostasis (HP:0011031)2.20573760
95Oral leukoplakia (HP:0002745)2.18001957
96Genital tract atresia (HP:0001827)2.17901141
97Congenital hepatic fibrosis (HP:0002612)2.17279600
98Metabolic acidosis (HP:0001942)2.16803784
99Prolonged bleeding time (HP:0003010)2.16706083
100Cerebellar dysplasia (HP:0007033)2.14685681
101Abnormal rod and cone electroretinograms (HP:0008323)2.14310425
102Hypoplasia of the thymus (HP:0000778)2.14153568
103Epistaxis (HP:0000421)2.14055175
104Abnormality of serine family amino acid metabolism (HP:0010894)2.13902922
105Abnormality of glycine metabolism (HP:0010895)2.13902922
106Aplasia/Hypoplasia of the uvula (HP:0010293)2.13901224
107Polydipsia (HP:0001959)2.12887785
108Abnormal drinking behavior (HP:0030082)2.12887785
109Type 2 muscle fiber atrophy (HP:0003554)2.11779019
110Microvesicular hepatic steatosis (HP:0001414)2.11496580
111Hyperglycinemia (HP:0002154)2.10870846
112Postaxial foot polydactyly (HP:0001830)2.10084636
113Vaginal atresia (HP:0000148)2.09388868
114Nausea (HP:0002018)2.08799527
115Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08544529
116Abnormality of alanine metabolism (HP:0010916)2.08544529
117Hyperalaninemia (HP:0003348)2.08544529
118Ketoacidosis (HP:0001993)2.07816851
119Proximal tubulopathy (HP:0000114)2.07656459
120Increased corneal curvature (HP:0100692)2.07375977
121Keratoconus (HP:0000563)2.07375977
122Progressive macrocephaly (HP:0004481)2.06207260
1233-Methylglutaconic aciduria (HP:0003535)2.04319970
124Deep venous thrombosis (HP:0002625)2.04170442
125Abnormality of pyrimidine metabolism (HP:0004353)2.03909774
126Progressive inability to walk (HP:0002505)2.02251479
127Male pseudohermaphroditism (HP:0000037)2.01776881
128Impaired platelet aggregation (HP:0003540)2.01325643
129Abnormal platelet function (HP:0011869)2.01325643
130Abnormality of serum amino acid levels (HP:0003112)1.99618106
131Microretrognathia (HP:0000308)1.99481126
132Chronic otitis media (HP:0000389)1.98967417
133Abnormality of the intrinsic pathway (HP:0010989)1.98886114
134Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98608364
135Abnormal protein N-linked glycosylation (HP:0012347)1.98608364
136Abnormal protein glycosylation (HP:0012346)1.98608364
137Abnormal glycosylation (HP:0012345)1.98608364
138Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98585232
139Abnormality of transition element cation homeostasis (HP:0011030)1.98461637
140Abnormality of the labia minora (HP:0012880)1.94967707
141Hypothermia (HP:0002045)1.93081484
142Petechiae (HP:0000967)1.92763683
143Muscle fiber atrophy (HP:0100295)1.92131750
144Renal cortical cysts (HP:0000803)1.92076674
145Delayed CNS myelination (HP:0002188)1.90071353
146Hypochromic anemia (HP:0001931)1.89169034
147Inability to walk (HP:0002540)1.89022925
148Thyroid-stimulating hormone excess (HP:0002925)1.87137906
149Xanthomatosis (HP:0000991)1.86538117
150Gliosis (HP:0002171)1.85827668
151Decreased central vision (HP:0007663)1.85719017
152Postaxial hand polydactyly (HP:0001162)1.84658832
153Optic disc pallor (HP:0000543)1.84335550
154Progressive cerebellar ataxia (HP:0002073)1.84051953
155Genetic anticipation (HP:0003743)1.80665877
156Colon cancer (HP:0003003)1.79681242
157Sloping forehead (HP:0000340)1.77676851
158Poor coordination (HP:0002370)1.77079973
159Meckel diverticulum (HP:0002245)1.77042211
160Abnormality of the ileum (HP:0001549)1.76812694
161Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76256200
162Preaxial hand polydactyly (HP:0001177)1.75959901
163Lissencephaly (HP:0001339)1.73529446
164Chromsome breakage (HP:0040012)1.72854904
165Small hand (HP:0200055)1.72661266
166Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69638875
167Astigmatism (HP:0000483)1.69608198
168Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69072399
169Oligohydramnios (HP:0001562)1.68947339
170Hemiparesis (HP:0001269)1.68834354
171Supernumerary spleens (HP:0009799)1.67585482
172Congenital sensorineural hearing impairment (HP:0008527)1.67563364
173Polyuria (HP:0000103)1.66534626
174Dandy-Walker malformation (HP:0001305)1.66495792

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.43869900
2BCKDK3.77975086
3EIF2AK13.51798253
4ZAK3.17061047
5BMPR1B3.11873331
6MAP4K13.06058324
7NUAK13.05908778
8NME22.90904450
9MAP4K22.72788796
10MUSK2.60986710
11FLT32.60663552
12KDR2.51359198
13ADRBK22.50354001
14GRK12.43998982
15WNK32.38583602
16TEC2.37266291
17BRSK22.16970184
18IRAK32.14376605
19PKN22.04324174
20TGFBR11.89749646
21BUB11.86437112
22WEE11.84718737
23INSRR1.80549772
24MAP2K31.78963481
25KIT1.77991219
26TGFBR21.74718681
27STK161.74628813
28TAOK31.73858130
29EIF2AK31.67824269
30IRAK41.63457200
31TXK1.62415534
32ZAP701.56944174
33TLK11.55996780
34VRK21.48017151
35BTK1.46971720
36MAP2K61.46685636
37STK38L1.45954803
38CDC71.43706237
39MAP3K111.43585609
40MAP3K41.39247182
41TBK11.36087292
42WNK41.35696257
43FGFR41.35061884
44ACVR1B1.33326416
45NME11.32975596
46LMTK21.31796722
47PLK31.25312086
48NEK11.24639165
49IKBKE1.24507746
50JAK31.23240966
51VRK11.22787972
52TYK21.21851040
53EEF2K1.21824998
54MAPK131.21290477
55PNCK1.19895454
56FGFR21.10985418
57TTN1.10543455
58CASK1.09650394
59PIM21.08380735
60OXSR11.08223969
61STK31.07101300
62TIE11.07099376
63RPS6KA41.06144584
64PLK21.05933460
65MYLK1.05887723
66TRIM281.05625448
67MST41.04085463
68EIF2AK21.03883545
69STK390.99447960
70RPS6KB20.98658277
71CSNK1G10.95757797
72CSNK1G20.95717215
73ERBB30.92502498
74TNIK0.92177209
75CSNK1G30.91806795
76SYK0.91008371
77LRRK20.90446923
78PAK30.89277211
79ADRBK10.89235682
80BLK0.88169007
81MAPKAPK30.87401991
82PRKCE0.87306441
83LATS10.85865855
84OBSCN0.84751398
85CSF1R0.84400836
86TAF10.83573366
87CSNK1A1L0.83005105
88NEK20.82540823
89CCNB10.81587751
90PRKG20.81082628
91TAOK20.80093343
92PTK2B0.79918615
93PINK10.79611527
94DAPK20.79560207
95MAPK110.79294090
96AURKB0.78361955
97STK100.76525359
98PRKCG0.76083860
99NLK0.74266676
100MAPKAPK50.72025665
101BRSK10.71618739
102MKNK10.70228155
103DYRK20.70209392
104PLK10.70130197
105CDK80.70068289
106JAK10.68293788
107PHKG10.66659917
108PHKG20.66659917
109LYN0.65603854
110CDK40.63345182
111DYRK30.62981817
112PASK0.62869179
113TTK0.62127384
114MAP3K30.61857788
115CHEK20.61811920
116PBK0.60861452
117GRK60.60639109
118RPS6KA50.60053601
119SCYL20.59790784
120PDK20.58926629
121IKBKB0.58811619
122ERN10.58524678
123PIM10.57546058
124NEK90.57321504
125ITK0.56447861
126EPHA40.55570914
127PIK3CG0.55056484
128STK40.54338786
129BCR0.53505262
130CAMKK20.53438304
131CAMK2A0.53331082
132MAP2K70.53095953
133TESK20.52987390
134PLK40.52770784
135ABL20.52148236
136LCK0.52093252
137CDK70.50324073
138MAP3K80.50247146
139MAP3K50.50034748
140MATK0.49001188
141JAK20.48265135
142MAPK40.47576460
143PDK30.47487853
144PDK40.47487853
145ATR0.46801068
146SRPK10.46683799
147PRKCI0.46107295
148MAP3K130.45003894
149PRKACA0.43603789
150PIK3CA0.43444429
151CDK190.42855953
152MAP3K120.42341355
153NTRK30.40717551
154MKNK20.40627445
155CAMK10.40523689
156TSSK60.39041860
157IRAK10.37597520
158PRKCQ0.37302025
159ATM0.36970555
160CSNK2A10.35456784
161PKN10.33483370
162CSNK1A10.33409805

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.90219858
2DNA replication_Homo sapiens_hsa030302.93237947
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.53308985
4Fatty acid degradation_Homo sapiens_hsa000712.39055162
5Propanoate metabolism_Homo sapiens_hsa006402.35103363
6Phototransduction_Homo sapiens_hsa047442.33829852
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.33161102
8RNA polymerase_Homo sapiens_hsa030202.26657777
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14990518
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.13390318
11Folate biosynthesis_Homo sapiens_hsa007902.12471853
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.09095688
13Nitrogen metabolism_Homo sapiens_hsa009101.89313222
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88913932
15Linoleic acid metabolism_Homo sapiens_hsa005911.87860714
16Pyrimidine metabolism_Homo sapiens_hsa002401.83699128
17Parkinsons disease_Homo sapiens_hsa050121.79946483
18Sulfur relay system_Homo sapiens_hsa041221.79640499
19Mismatch repair_Homo sapiens_hsa034301.75573538
20Proteasome_Homo sapiens_hsa030501.73998819
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73752755
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71548573
23Peroxisome_Homo sapiens_hsa041461.70865230
24Carbon metabolism_Homo sapiens_hsa012001.68362103
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.62878266
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59490838
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59200743
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56968201
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.56910086
30Pyruvate metabolism_Homo sapiens_hsa006201.56332057
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55362671
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.54328501
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49039775
34One carbon pool by folate_Homo sapiens_hsa006701.48051686
35Sulfur metabolism_Homo sapiens_hsa009201.47801470
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47203119
37Tryptophan metabolism_Homo sapiens_hsa003801.46273745
38Oxidative phosphorylation_Homo sapiens_hsa001901.45395116
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44575071
40Fatty acid metabolism_Homo sapiens_hsa012121.43738339
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.42466851
42Base excision repair_Homo sapiens_hsa034101.41991807
43Nicotine addiction_Homo sapiens_hsa050331.41659534
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41492418
45Caffeine metabolism_Homo sapiens_hsa002321.41133456
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.40537308
47Homologous recombination_Homo sapiens_hsa034401.39998146
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37603757
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36765199
50Biosynthesis of amino acids_Homo sapiens_hsa012301.33468338
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32711270
52Pentose phosphate pathway_Homo sapiens_hsa000301.32195385
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29808139
54beta-Alanine metabolism_Homo sapiens_hsa004101.27610956
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22026272
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.21247534
57Fatty acid elongation_Homo sapiens_hsa000621.20112797
58Spliceosome_Homo sapiens_hsa030401.18958684
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13615691
60Primary immunodeficiency_Homo sapiens_hsa053401.13390327
61Ether lipid metabolism_Homo sapiens_hsa005651.10571957
62Huntingtons disease_Homo sapiens_hsa050161.10538100
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02769106
64Selenocompound metabolism_Homo sapiens_hsa004501.02739084
65Butanoate metabolism_Homo sapiens_hsa006501.00378526
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00283817
67Arginine biosynthesis_Homo sapiens_hsa002200.99071540
68Alzheimers disease_Homo sapiens_hsa050100.98570841
69Purine metabolism_Homo sapiens_hsa002300.96956997
70Nucleotide excision repair_Homo sapiens_hsa034200.94985378
71Olfactory transduction_Homo sapiens_hsa047400.94769944
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92663202
73Taste transduction_Homo sapiens_hsa047420.92540948
74RNA degradation_Homo sapiens_hsa030180.92316273
75Starch and sucrose metabolism_Homo sapiens_hsa005000.90745187
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89099216
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88287738
78PPAR signaling pathway_Homo sapiens_hsa033200.85986446
79Chemical carcinogenesis_Homo sapiens_hsa052040.85598079
80Protein export_Homo sapiens_hsa030600.85305903
81Complement and coagulation cascades_Homo sapiens_hsa046100.85288572
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83764071
83Arachidonic acid metabolism_Homo sapiens_hsa005900.83071184
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80293838
85Glutathione metabolism_Homo sapiens_hsa004800.79748320
86Retinol metabolism_Homo sapiens_hsa008300.78901343
87RNA transport_Homo sapiens_hsa030130.76315326
88Steroid biosynthesis_Homo sapiens_hsa001000.74251578
89Morphine addiction_Homo sapiens_hsa050320.71718214
90Histidine metabolism_Homo sapiens_hsa003400.71695087
91Herpes simplex infection_Homo sapiens_hsa051680.71037027
92Galactose metabolism_Homo sapiens_hsa000520.70961399
93Metabolic pathways_Homo sapiens_hsa011000.70943541
94Regulation of autophagy_Homo sapiens_hsa041400.69958081
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69404969
96Fat digestion and absorption_Homo sapiens_hsa049750.68275713
97Cell cycle_Homo sapiens_hsa041100.66973919
98Fanconi anemia pathway_Homo sapiens_hsa034600.64984011
99Non-homologous end-joining_Homo sapiens_hsa034500.64812302
100Arginine and proline metabolism_Homo sapiens_hsa003300.64692252
101ABC transporters_Homo sapiens_hsa020100.63782209
102Circadian rhythm_Homo sapiens_hsa047100.63772605
103Glycerolipid metabolism_Homo sapiens_hsa005610.58772432
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56976648
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55396733
106Insulin secretion_Homo sapiens_hsa049110.54077409
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.53480929
108Staphylococcus aureus infection_Homo sapiens_hsa051500.52965195
109GABAergic synapse_Homo sapiens_hsa047270.52772806
110Collecting duct acid secretion_Homo sapiens_hsa049660.52624429
111Serotonergic synapse_Homo sapiens_hsa047260.52569301
112Cardiac muscle contraction_Homo sapiens_hsa042600.50876074
113Sphingolipid metabolism_Homo sapiens_hsa006000.50559814
114Tyrosine metabolism_Homo sapiens_hsa003500.49656701
115N-Glycan biosynthesis_Homo sapiens_hsa005100.49557042
116Measles_Homo sapiens_hsa051620.48571098
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.47760194
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46962033
119Vitamin B6 metabolism_Homo sapiens_hsa007500.45921545
120Glutamatergic synapse_Homo sapiens_hsa047240.45005569
121Circadian entrainment_Homo sapiens_hsa047130.44490894
122Lysine degradation_Homo sapiens_hsa003100.43420096
123Vitamin digestion and absorption_Homo sapiens_hsa049770.42903770
124Ovarian steroidogenesis_Homo sapiens_hsa049130.42588451
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41390199
126Antigen processing and presentation_Homo sapiens_hsa046120.40550356
127Epstein-Barr virus infection_Homo sapiens_hsa051690.40299572
128Basal transcription factors_Homo sapiens_hsa030220.40206424
129Phenylalanine metabolism_Homo sapiens_hsa003600.38356542
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37342567
131NF-kappa B signaling pathway_Homo sapiens_hsa040640.34866214
132Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34710847
133Fructose and mannose metabolism_Homo sapiens_hsa000510.34387329
134p53 signaling pathway_Homo sapiens_hsa041150.31498734
135Systemic lupus erythematosus_Homo sapiens_hsa053220.30344508
136Other glycan degradation_Homo sapiens_hsa005110.30306091
137Hematopoietic cell lineage_Homo sapiens_hsa046400.29862827

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