NUDT7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.56239991
2L-phenylalanine catabolic process (GO:0006559)7.56239991
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.21187831
4L-phenylalanine metabolic process (GO:0006558)7.21187831
5aromatic amino acid family catabolic process (GO:0009074)6.95261200
6indole-containing compound catabolic process (GO:0042436)6.49294384
7indolalkylamine catabolic process (GO:0046218)6.49294384
8tryptophan catabolic process (GO:0006569)6.49294384
9kynurenine metabolic process (GO:0070189)6.27812293
10bile acid biosynthetic process (GO:0006699)6.19592948
11tryptophan metabolic process (GO:0006568)6.08480240
12glyoxylate metabolic process (GO:0046487)5.82709873
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.82055610
14complement activation, alternative pathway (GO:0006957)5.78343766
15regulation of protein activation cascade (GO:2000257)5.65804491
16urea cycle (GO:0000050)5.60011201
17urea metabolic process (GO:0019627)5.60011201
18alpha-linolenic acid metabolic process (GO:0036109)5.58451476
19regulation of complement activation (GO:0030449)5.35238178
20negative regulation of fibrinolysis (GO:0051918)5.28532776
21protein carboxylation (GO:0018214)5.24068425
22peptidyl-glutamic acid carboxylation (GO:0017187)5.24068425
23cysteine metabolic process (GO:0006534)5.23684868
24sulfur amino acid catabolic process (GO:0000098)5.21808005
25regulation of fibrinolysis (GO:0051917)5.20621435
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.16056763
27nitrogen cycle metabolic process (GO:0071941)5.15457456
28bile acid metabolic process (GO:0008206)5.14034622
29high-density lipoprotein particle remodeling (GO:0034375)5.05548106
30aromatic amino acid family metabolic process (GO:0009072)5.03186828
31serine family amino acid catabolic process (GO:0009071)4.94908744
32regulation of triglyceride catabolic process (GO:0010896)4.82420739
33homocysteine metabolic process (GO:0050667)4.74861774
34lysine catabolic process (GO:0006554)4.71762262
35lysine metabolic process (GO:0006553)4.71762262
36tyrosine metabolic process (GO:0006570)4.70079355
37alpha-amino acid catabolic process (GO:1901606)4.63834828
38indolalkylamine metabolic process (GO:0006586)4.60554909
39acylglycerol homeostasis (GO:0055090)4.55980505
40triglyceride homeostasis (GO:0070328)4.55980505
41cellular biogenic amine catabolic process (GO:0042402)4.53674824
42amine catabolic process (GO:0009310)4.53674824
43amino-acid betaine metabolic process (GO:0006577)4.51711949
44reverse cholesterol transport (GO:0043691)4.43751956
45plasma lipoprotein particle remodeling (GO:0034369)4.40763994
46protein-lipid complex remodeling (GO:0034368)4.40763994
47macromolecular complex remodeling (GO:0034367)4.40763994
48bile acid and bile salt transport (GO:0015721)4.39255126
49ethanol oxidation (GO:0006069)4.36664535
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.35350730
51imidazole-containing compound metabolic process (GO:0052803)4.35160394
52cytolysis (GO:0019835)4.32839650
53glycine metabolic process (GO:0006544)4.30399346
54water-soluble vitamin biosynthetic process (GO:0042364)4.29049664
55regulation of cholesterol esterification (GO:0010872)4.28453509
56cellular amino acid catabolic process (GO:0009063)4.26113192
57cellular ketone body metabolic process (GO:0046950)4.18427501
58cellular glucuronidation (GO:0052695)4.18188928
59phospholipid efflux (GO:0033700)4.17410599
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.17154300
61glutamate metabolic process (GO:0006536)4.14322333
62benzene-containing compound metabolic process (GO:0042537)4.12716072
63negative regulation of sterol transport (GO:0032372)4.10146342
64negative regulation of cholesterol transport (GO:0032375)4.10146342
65serine family amino acid metabolic process (GO:0009069)4.08673869
66complement activation, classical pathway (GO:0006958)4.06816348
67protein complex biogenesis (GO:0070271)4.06093132
68plasma lipoprotein particle clearance (GO:0034381)4.05511346
69cellular modified amino acid catabolic process (GO:0042219)4.04849245
70respiratory chain complex IV assembly (GO:0008535)4.04198849
71dicarboxylic acid biosynthetic process (GO:0043650)3.98915681
72complement activation (GO:0006956)3.94574838
73* coenzyme catabolic process (GO:0009109)3.93129757
74cholesterol efflux (GO:0033344)3.90131642
75ATP synthesis coupled proton transport (GO:0015986)3.89270092
76energy coupled proton transport, down electrochemical gradient (GO:0015985)3.89270092
77arginine metabolic process (GO:0006525)3.88581047
78fibrinolysis (GO:0042730)3.88168082
79aldehyde catabolic process (GO:0046185)3.87973718
80protein activation cascade (GO:0072376)3.84012518
81regulation of bile acid biosynthetic process (GO:0070857)3.80827126
82serine family amino acid biosynthetic process (GO:0009070)3.80709203
83blood coagulation, intrinsic pathway (GO:0007597)3.78881060
84carboxylic acid catabolic process (GO:0046395)3.76902528
85organic acid catabolic process (GO:0016054)3.76902528
86uronic acid metabolic process (GO:0006063)3.70981872
87glucuronate metabolic process (GO:0019585)3.70981872
88cytochrome complex assembly (GO:0017004)3.68035716
89NAD biosynthetic process (GO:0009435)3.67562354
90phospholipid homeostasis (GO:0055091)3.66913926
91proteasome assembly (GO:0043248)3.66670301
92xenobiotic catabolic process (GO:0042178)3.65778554
93low-density lipoprotein particle remodeling (GO:0034374)3.65612146
94plasma lipoprotein particle assembly (GO:0034377)3.65528440
95short-chain fatty acid metabolic process (GO:0046459)3.65304413
96mitochondrial respiratory chain complex assembly (GO:0033108)3.63553848
97* acetyl-CoA metabolic process (GO:0006084)3.62861310
98establishment of protein localization to mitochondrial membrane (GO:0090151)3.62207926
99respiratory electron transport chain (GO:0022904)3.62092824
100nicotinamide nucleotide biosynthetic process (GO:0019359)3.61870131
101pyridine nucleotide biosynthetic process (GO:0019363)3.61870131
102positive regulation of lipoprotein lipase activity (GO:0051006)3.61520704
103positive regulation of triglyceride lipase activity (GO:0061365)3.61520704
104ketone body metabolic process (GO:1902224)3.61361278
105electron transport chain (GO:0022900)3.61196932
106regulation of cholesterol homeostasis (GO:2000188)3.61076690
107cholesterol homeostasis (GO:0042632)3.60336067
108drug catabolic process (GO:0042737)3.59996184
109positive regulation of lipid catabolic process (GO:0050996)3.58888054
110lactate metabolic process (GO:0006089)3.57578068
111very-low-density lipoprotein particle assembly (GO:0034379)3.57133159
112fatty acid oxidation (GO:0019395)3.56461608
113fatty acid beta-oxidation (GO:0006635)3.55562826
114sterol homeostasis (GO:0055092)3.54419006
115negative regulation of lipase activity (GO:0060192)3.54191020
116exogenous drug catabolic process (GO:0042738)3.53325621
117mitochondrial respiratory chain complex I assembly (GO:0032981)3.52908195
118NADH dehydrogenase complex assembly (GO:0010257)3.52908195
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.52908195
120branched-chain amino acid catabolic process (GO:0009083)3.46511386
121L-methionine salvage (GO:0071267)3.42600236
122L-methionine biosynthetic process (GO:0071265)3.42600236
123amino acid salvage (GO:0043102)3.42600236
124regulation of glucokinase activity (GO:0033131)3.34292506
125regulation of hexokinase activity (GO:1903299)3.34292506
126oxidative phosphorylation (GO:0006119)3.28556312
127tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.23095905
128RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.23095905
129platelet dense granule organization (GO:0060155)3.21063020
130response to nitrosative stress (GO:0051409)3.19038698
131S-adenosylmethionine metabolic process (GO:0046500)3.15634106
132DNA double-strand break processing (GO:0000729)3.10589145
133L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.02861111
134epithelial cilium movement (GO:0003351)2.99849318
135preassembly of GPI anchor in ER membrane (GO:0016254)2.98264439
136mannosylation (GO:0097502)2.95537900
137phenylpropanoid metabolic process (GO:0009698)2.94958107
138chaperone-mediated protein transport (GO:0072321)2.89638763
139signal peptide processing (GO:0006465)2.87858149
140branched-chain amino acid metabolic process (GO:0009081)2.86651354
141intraciliary transport (GO:0042073)2.81745469
142regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.81533533
143omega-hydroxylase P450 pathway (GO:0097267)2.77172229
144C-terminal protein lipidation (GO:0006501)2.76703153
145hydrogen ion transmembrane transport (GO:1902600)2.76549787
146vitamin biosynthetic process (GO:0009110)2.76202690
147nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75332549
148response to pheromone (GO:0019236)2.73175124
149GPI anchor biosynthetic process (GO:0006506)2.72238601
150DNA deamination (GO:0045006)2.72079986
151heme transport (GO:0015886)2.71519163
152protein neddylation (GO:0045116)2.71349182
153GPI anchor metabolic process (GO:0006505)2.70455788
154positive regulation of glycolytic process (GO:0045821)2.69938947
155piRNA metabolic process (GO:0034587)2.65214056
156regulation of mitochondrial translation (GO:0070129)2.63755192
157cilium movement (GO:0003341)2.62165090
158ATP biosynthetic process (GO:0006754)2.60008261
159C-terminal protein amino acid modification (GO:0018410)2.58231158
160proton transport (GO:0015992)2.56917818
161oxidative demethylation (GO:0070989)2.56843911
162regulation of cilium movement (GO:0003352)2.52158593
163hydrogen transport (GO:0006818)2.52012645
164epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.51769993
165exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.50465106
166regulation of acyl-CoA biosynthetic process (GO:0050812)2.50108982
167cilium morphogenesis (GO:0060271)2.48921268
168intracellular protein transmembrane import (GO:0044743)2.48038869
169glutathione derivative biosynthetic process (GO:1901687)2.47768068
170glutathione derivative metabolic process (GO:1901685)2.47768068
171axonemal dynein complex assembly (GO:0070286)2.46682294
172phosphorylated carbohydrate dephosphorylation (GO:0046838)2.46618862
173inositol phosphate dephosphorylation (GO:0046855)2.46618862
174nonmotile primary cilium assembly (GO:0035058)2.46175168
175mitochondrial DNA replication (GO:0006264)2.46122261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.25525533
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.20202609
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.09768460
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.39996429
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.32138763
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.03007592
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.00398832
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.05852241
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.98767275
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.69641929
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.39547235
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.25697422
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.92096823
14VDR_22108803_ChIP-Seq_LS180_Human2.78097456
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.66528818
16ZNF274_21170338_ChIP-Seq_K562_Hela2.63603294
17IGF1R_20145208_ChIP-Seq_DFB_Human2.51240081
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31228625
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.30013975
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22126084
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16210075
22ELK1_19687146_ChIP-ChIP_HELA_Human2.10924616
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.00512855
24* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7359877
25GBX2_23144817_ChIP-Seq_PC3_Human1.99666904
26VDR_23849224_ChIP-Seq_CD4+_Human1.97104799
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.96885113
28EWS_26573619_Chip-Seq_HEK293_Human1.92901954
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.92688024
30FUS_26573619_Chip-Seq_HEK293_Human1.87329241
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85283978
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83716161
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82017889
34GATA1_22025678_ChIP-Seq_K562_Human1.77733001
35* P300_19829295_ChIP-Seq_ESCs_Human1.77508856
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76917519
37MYC_18940864_ChIP-ChIP_HL60_Human1.76434373
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.76412107
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76138501
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.70457981
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63697702
42ER_23166858_ChIP-Seq_MCF-7_Human1.63418319
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61861911
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61439370
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60376712
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59546947
47FOXP3_21729870_ChIP-Seq_TREG_Human1.56999511
48* FOXA2_19822575_ChIP-Seq_HepG2_Human1.54329010
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53861329
50* HTT_18923047_ChIP-ChIP_STHdh_Human1.52395058
51CLOCK_20551151_ChIP-Seq_293T_Human1.46646215
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43180402
53CBP_20019798_ChIP-Seq_JUKART_Human1.43180402
54TP53_22573176_ChIP-Seq_HFKS_Human1.38723789
55HNF4A_19822575_ChIP-Seq_HepG2_Human1.38262700
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37252492
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37035236
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36530946
59SOX2_19829295_ChIP-Seq_ESCs_Human1.35350412
60NANOG_19829295_ChIP-Seq_ESCs_Human1.35350412
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34494278
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33598708
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33396327
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.33007226
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33007226
66* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31224331
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30205801
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.29605511
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29475396
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27342576
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22644280
72TCF4_22108803_ChIP-Seq_LS180_Human1.22057807
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21426595
74NCOR_22424771_ChIP-Seq_293T_Human1.20556582
75RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19980658
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.19726328
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19389364
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.18692206
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17624329
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17194047
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16800698
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14650501
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13340881
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10521139
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10089102
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09891621
87SMAD4_21799915_ChIP-Seq_A2780_Human1.09116780
88IRF8_22096565_ChIP-ChIP_GC-B_Human1.08904301
89AR_25329375_ChIP-Seq_VCAP_Human1.05712081
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03269338
91* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02835214
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02430175
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.00178647
94SMAD3_21741376_ChIP-Seq_EPCs_Human0.99056989
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.98207884
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97993862
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97152977
98TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97136590
99PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96535304
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95179426
101PHF8_20622853_ChIP-Seq_HELA_Human0.95127001
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94465735
103* TCF4_23295773_ChIP-Seq_U87_Human0.94382665
104* RUNX2_22187159_ChIP-Seq_PCA_Human0.92983019
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92226938
106BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91388863
107SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90866117
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90261755
109PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90123811
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88748081
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87774948
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84934051
113AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84191899
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83424382
115GATA4_25053715_ChIP-Seq_YYC3_Human0.78745876
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76549317
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76545019
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76171189
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74439939
120TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.73751535
121RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72391898
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72116743
123RARA_24833708_ChIP-Seq_LIVER_Mouse0.70596279
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69938125
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.68455345
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.68455345
127SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68102756
128ESR1_15608294_ChIP-ChIP_MCF-7_Human0.62424389
129RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62359167
130RARB_24833708_ChIP-Seq_LIVER_Mouse0.62164886
131* AR_20517297_ChIP-Seq_VCAP_Human0.61539766
132CEBPB_22108803_ChIP-Seq_LS180_Human0.59890709
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.58934911
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58529175
135FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.58520139
136BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57456583
137PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.55379511
138* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55290205
139ESR2_21235772_ChIP-Seq_MCF-7_Human0.54795125
140* FOXA1_25552417_ChIP-Seq_VCAP_Human0.53780457
141PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.53440897
142TAF15_26573619_Chip-Seq_HEK293_Human0.52510430
143ZNF263_19887448_ChIP-Seq_K562_Human0.52113433
144ESET_19884257_ChIP-Seq_ESCs_Mouse0.51634582
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51537977
146CBP_21632823_ChIP-Seq_H3396_Human0.51422772
147* STAT1_17558387_ChIP-Seq_HELA_Human0.50758265
148STAT3_1855785_ChIP-Seq_MESCs_Mouse0.48989075
149CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.48874485
150MYC_19915707_ChIP-ChIP_AK7_Human0.48628013
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.48319374
152ERG_20517297_ChIP-Seq_VCAP_Human0.48193072
153EGR1_19032775_ChIP-ChIP_M12_Human0.47671718
154NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.47270416
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.46629238
156SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.45958256
157GATA1_19941827_ChIP-Seq_MEL_Mouse0.44782978
158ESR1_21235772_ChIP-Seq_MCF-7_Human0.44274438
159IRF1_19129219_ChIP-ChIP_H3396_Human0.43479183
160* P53_21459846_ChIP-Seq_SAOS-2_Human0.43298553
161PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43011281
162FOXO3_23340844_ChIP-Seq_DLD1_Human0.41705266
163TAF2_19829295_ChIP-Seq_ESCs_Human0.41648203
164BCAT_22108803_ChIP-Seq_LS180_Human0.40986436
165FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.40759525
166EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.40475869
167CDX2_20551321_ChIP-Seq_CACO-2_Human0.40340091
168GATA2_19941826_ChIP-Seq_K562_Human0.39671796
169CRX_20693478_ChIP-Seq_RETINA_Mouse0.39606144
170* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.39241415
171SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38644049
172STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37811469
173EZH2_27294783_Chip-Seq_NPCs_Mouse0.37680845
174CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.37497636
175SPI1_26923725_Chip-Seq_HPCs_Mouse0.37054270
176OCT4_21477851_ChIP-Seq_ESCs_Mouse0.37011180
177PPAR_26484153_Chip-Seq_NCI-H1993_Human0.36548644
178* FOXH1_21741376_ChIP-Seq_EPCs_Human0.35911018
179LXR_22292898_ChIP-Seq_THP-1_Human0.35455109
180CDX2_22108803_ChIP-Seq_LS180_Human0.35454504
181MYC_27129775_Chip-Seq_CORNEA_Mouse0.35321144
182GATA6_25053715_ChIP-Seq_YYC3_Human0.35025829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.15407652
2MP0005360_urolithiasis7.36810708
3MP0005085_abnormal_gallbladder_physiolo6.52750222
4MP0005365_abnormal_bile_salt6.21226579
5MP0008875_abnormal_xenobiotic_pharmacok4.86072565
6MP0003806_abnormal_nucleotide_metabolis4.27552544
7MP0003252_abnormal_bile_duct4.00154851
8MP0010329_abnormal_lipoprotein_level3.52940267
9MP0005083_abnormal_biliary_tract3.09443422
10MP0009840_abnormal_foam_cell2.95147811
11MP0003195_calcinosis2.80935205
12MP0002102_abnormal_ear_morphology2.76851601
13MP0005332_abnormal_amino_acid2.68522419
14MP0001666_abnormal_nutrient_absorption2.59283258
15MP0006072_abnormal_retinal_apoptosis2.58476636
16MP0008877_abnormal_DNA_methylation2.41744795
17MP0003191_abnormal_cellular_cholesterol2.25616896
18MP0000609_abnormal_liver_physiology2.18880087
19MP0006292_abnormal_olfactory_placode2.16919007
20MP0002118_abnormal_lipid_homeostasis2.14732628
21MP0002638_abnormal_pupillary_reflex2.08939768
22MP0001984_abnormal_olfaction2.07830169
23MP0003868_abnormal_feces_composition2.03546606
24MP0004019_abnormal_vitamin_homeostasis2.01723218
25MP0003136_yellow_coat_color1.96859971
26MP0002138_abnormal_hepatobiliary_system1.90456675
27MP0002938_white_spotting1.90119579
28MP0005551_abnormal_eye_electrophysiolog1.87366616
29MP0005319_abnormal_enzyme/_coenzyme1.86079553
30MP0008995_early_reproductive_senescence1.74560027
31MP0009697_abnormal_copulation1.74002175
32MP0008789_abnormal_olfactory_epithelium1.73269002
33MP0001764_abnormal_homeostasis1.71251725
34MP0005253_abnormal_eye_physiology1.65654799
35MP0005584_abnormal_enzyme/coenzyme_acti1.55078107
36MP0000372_irregular_coat_pigmentation1.54804270
37MP0008058_abnormal_DNA_repair1.51266899
38MP0005379_endocrine/exocrine_gland_phen1.44943043
39MP0003122_maternal_imprinting1.42314166
40MP0001529_abnormal_vocalization1.36678763
41MP0002909_abnormal_adrenal_gland1.36184914
42MP0002090_abnormal_vision1.35094979
43MP0000631_abnormal_neuroendocrine_gland1.34577928
44MP0003186_abnormal_redox_activity1.34481105
45MP0002234_abnormal_pharynx_morphology1.33606127
46MP0003880_abnormal_central_pattern1.32405078
47MP0003011_delayed_dark_adaptation1.32297336
48MP0005647_abnormal_sex_gland1.28967536
49MP0005451_abnormal_body_composition1.27827352
50MP0003656_abnormal_erythrocyte_physiolo1.27188305
51MP0006276_abnormal_autonomic_nervous1.26644994
52MP0003787_abnormal_imprinting1.25997134
53MP0003786_premature_aging1.25605309
54MP0009643_abnormal_urine_homeostasis1.23047562
55MP0005394_taste/olfaction_phenotype1.22901476
56MP0005499_abnormal_olfactory_system1.22901476
57MP0009046_muscle_twitch1.22509657
58MP0000598_abnormal_liver_morphology1.18096525
59MP0002277_abnormal_respiratory_mucosa1.15777446
60MP0005410_abnormal_fertilization1.15524567
61MP0001485_abnormal_pinna_reflex1.13031648
62MP0005174_abnormal_tail_pigmentation1.12687661
63MP0005670_abnormal_white_adipose1.10773880
64MP0004215_abnormal_myocardial_fiber1.09938963
65MP0009764_decreased_sensitivity_to1.08971926
66MP0010368_abnormal_lymphatic_system1.08530544
67MP0005646_abnormal_pituitary_gland1.05445752
68MP0001929_abnormal_gametogenesis1.04180144
69MP0009763_increased_sensitivity_to1.03683347
70MP0000566_synostosis1.03378240
71MP0005645_abnormal_hypothalamus_physiol1.01721136
72MP0006036_abnormal_mitochondrial_physio0.98983042
73MP0005084_abnormal_gallbladder_morpholo0.97958758
74MP0003646_muscle_fatigue0.96279832
75MP0002254_reproductive_system_inflammat0.95100813
76MP0001293_anophthalmia0.94800064
77MP0005636_abnormal_mineral_homeostasis0.94066408
78MP0004142_abnormal_muscle_tone0.93745526
79MP0008469_abnormal_protein_level0.93402112
80MP0003283_abnormal_digestive_organ0.92486980
81MP0002163_abnormal_gland_morphology0.92348948
82MP0001986_abnormal_taste_sensitivity0.92314944
83MP0004130_abnormal_muscle_cell0.91629540
84MP0003705_abnormal_hypodermis_morpholog0.91016057
85MP0004133_heterotaxia0.89615354
86MP0005220_abnormal_exocrine_pancreas0.89583066
87MP0009642_abnormal_blood_homeostasis0.87956538
88MP0003698_abnormal_male_reproductive0.87515394
89MP0002653_abnormal_ependyma_morphology0.87353536
90MP0003121_genomic_imprinting0.86607669
91MP0000604_amyloidosis0.85845010
92MP0002095_abnormal_skin_pigmentation0.85715475
93MP0001324_abnormal_eye_pigmentation0.85493234
94MP0005408_hypopigmentation0.85378414
95MP0002078_abnormal_glucose_homeostasis0.85002286
96MP0002876_abnormal_thyroid_physiology0.84436019
97MP0002971_abnormal_brown_adipose0.84323419
98MP0000653_abnormal_sex_gland0.83028665
99MP0002272_abnormal_nervous_system0.81265613
100MP0002210_abnormal_sex_determination0.80048420
101MP0005376_homeostasis/metabolism_phenot0.79635109
102MP0005535_abnormal_body_temperature0.79473330
103MP0002160_abnormal_reproductive_system0.78511177
104MP0005334_abnormal_fat_pad0.78192210
105MP0009765_abnormal_xenobiotic_induced0.75969142
106MP0002693_abnormal_pancreas_physiology0.74952544
107MP0005389_reproductive_system_phenotype0.74858620
108MP0001501_abnormal_sleep_pattern0.74627569
109MP0004043_abnormal_pH_regulation0.74422242
110MP0001145_abnormal_male_reproductive0.74128968
111MP0002837_dystrophic_cardiac_calcinosis0.73352072
112MP0005266_abnormal_metabolism0.68824218
113MP0004381_abnormal_hair_follicle0.67193273
114MP0003724_increased_susceptibility_to0.66936160
115MP0006035_abnormal_mitochondrial_morpho0.63458852
116MP0001661_extended_life_span0.62201205
117MP0002928_abnormal_bile_duct0.60607282
118MP0000639_abnormal_adrenal_gland0.58139431
119MP0009384_cardiac_valve_regurgitation0.57703198
120MP0003690_abnormal_glial_cell0.57661552
121MP0005666_abnormal_adipose_tissue0.56726385
122MP0003718_maternal_effect0.55399782
123MP0005448_abnormal_energy_balance0.55126264
124MP0000579_abnormal_nail_morphology0.55084407
125MP0001756_abnormal_urination0.54380776
126MP0005464_abnormal_platelet_physiology0.51811490
127MP0004782_abnormal_surfactant_physiolog0.50616441
128MP0005395_other_phenotype0.48324737
129MP0009379_abnormal_foot_pigmentation0.47675340
130MP0003953_abnormal_hormone_level0.44509594
131MP0003436_decreased_susceptibility_to0.43968788
132MP0005166_decreased_susceptibility_to0.42839836
133MP0002136_abnormal_kidney_physiology0.41354584
134MP0003329_amyloid_beta_deposits0.40531356
135MP0008873_increased_physiological_sensi0.39651021
136MP0008874_decreased_physiological_sensi0.39594858
137MP0003638_abnormal_response/metabolism_0.39227101
138MP0002970_abnormal_white_adipose0.39211700
139MP0009053_abnormal_anal_canal0.38651907
140MP0009115_abnormal_fat_cell0.38487880
141MP0000230_abnormal_systemic_arterial0.37247391
142MP0001853_heart_inflammation0.36395779
143MP0002822_catalepsy0.35226789
144MP0003075_altered_response_to0.34198888
145MP0001881_abnormal_mammary_gland0.33640790
146MP0002796_impaired_skin_barrier0.32486524
147MP0005075_abnormal_melanosome_morpholog0.32419838
148MP0002132_abnormal_respiratory_system0.32366107
149MP0009672_abnormal_birth_weight0.32054255
150MP0001944_abnormal_pancreas_morphology0.30157387
151MP0001845_abnormal_inflammatory_respons0.29790281
152MP0000427_abnormal_hair_cycle0.29523606
153MP0004147_increased_porphyrin_level0.29153335
154MP0002060_abnormal_skin_morphology0.28646371
155MP0005248_abnormal_Harderian_gland0.28360841
156MP0000249_abnormal_blood_vessel0.28310552
157MP0008872_abnormal_physiological_respon0.26555741
158MP0003959_abnormal_lean_body0.26097113

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.50471075
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.27959118
3Deep venous thrombosis (HP:0002625)6.97925238
4Prolonged partial thromboplastin time (HP:0003645)6.46257264
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.35514594
6Xanthomatosis (HP:0000991)6.07958290
7Complement deficiency (HP:0004431)6.03841009
8Hypobetalipoproteinemia (HP:0003563)6.00823384
9Hyperlipoproteinemia (HP:0010980)5.31506077
10Joint hemorrhage (HP:0005261)4.62238714
11Epidermoid cyst (HP:0200040)4.56289078
12Hyperammonemia (HP:0001987)4.54620143
13Hypolipoproteinemia (HP:0010981)4.53951112
14Hyperglycinemia (HP:0002154)4.49167600
15Abnormality of the common coagulation pathway (HP:0010990)4.38710765
16Abnormality of complement system (HP:0005339)4.38481173
17Ketosis (HP:0001946)4.30986974
18Fat malabsorption (HP:0002630)4.24919533
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.17854516
20Hypoglycemic coma (HP:0001325)4.14800398
21Abnormality of methionine metabolism (HP:0010901)4.07376210
22Abnormality of sulfur amino acid metabolism (HP:0004339)4.02493468
23Hypoalphalipoproteinemia (HP:0003233)4.01870412
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.97775300
25Acute necrotizing encephalopathy (HP:0006965)3.97420531
26Hyperglycinuria (HP:0003108)3.97002739
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.95355500
28Abnormality of serine family amino acid metabolism (HP:0010894)3.94374595
29Abnormality of glycine metabolism (HP:0010895)3.94374595
30Abnormality of the intrinsic pathway (HP:0010989)3.86022865
31Hepatic necrosis (HP:0002605)3.85196771
32Conjugated hyperbilirubinemia (HP:0002908)3.82363132
33Acute encephalopathy (HP:0006846)3.80027096
34Mitochondrial inheritance (HP:0001427)3.72080760
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.62438758
36Abnormality of pyrimidine metabolism (HP:0004353)3.61650952
37Abnormal mitochondria in muscle tissue (HP:0008316)3.58933141
38Hepatocellular necrosis (HP:0001404)3.57846662
39Abnormality of fatty-acid metabolism (HP:0004359)3.56401936
40Progressive macrocephaly (HP:0004481)3.51728267
41Increased CSF lactate (HP:0002490)3.38693654
42Hypercholesterolemia (HP:0003124)3.36786967
43True hermaphroditism (HP:0010459)3.33601371
44Hyperbilirubinemia (HP:0002904)3.28657279
45Steatorrhea (HP:0002570)3.28214796
46Abnormality of serum amino acid levels (HP:0003112)3.16356634
47Pancreatic fibrosis (HP:0100732)3.14757285
48Ketoacidosis (HP:0001993)3.13130042
49Pancreatic cysts (HP:0001737)3.01863089
50Myocardial infarction (HP:0001658)3.01039418
51Spontaneous abortion (HP:0005268)2.99708756
52Lipid accumulation in hepatocytes (HP:0006561)2.99216421
53Delayed CNS myelination (HP:0002188)2.99028850
54Systemic lupus erythematosus (HP:0002725)2.98354769
55Abnormality of nucleobase metabolism (HP:0010932)2.95980540
56Medial flaring of the eyebrow (HP:0010747)2.95401047
57Increased hepatocellular lipid droplets (HP:0006565)2.87581182
58Hepatocellular carcinoma (HP:0001402)2.86969905
59Recurrent gram-negative bacterial infections (HP:0005420)2.85443381
60Hypochromic microcytic anemia (HP:0004840)2.84802125
61Skin nodule (HP:0200036)2.82649646
62Metabolic acidosis (HP:0001942)2.77818123
63Dicarboxylic aciduria (HP:0003215)2.75571972
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.75571972
65Glycosuria (HP:0003076)2.69428671
66Abnormality of urine glucose concentration (HP:0011016)2.69428671
67Hypoglycemic seizures (HP:0002173)2.69129149
68Lethargy (HP:0001254)2.67462985
69Nephronophthisis (HP:0000090)2.65776531
70Abnormality of purine metabolism (HP:0004352)2.63145333
71Abnormality of midbrain morphology (HP:0002418)2.61909057
72Molar tooth sign on MRI (HP:0002419)2.61909057
73Abnormality of the labia minora (HP:0012880)2.60692704
74Large for gestational age (HP:0001520)2.59663235
75Type I transferrin isoform profile (HP:0003642)2.58320164
76Renal Fanconi syndrome (HP:0001994)2.58189326
77Cerebral edema (HP:0002181)2.57271852
78Methylmalonic acidemia (HP:0002912)2.55758602
79Acanthocytosis (HP:0001927)2.54271079
80Abnormal gallbladder morphology (HP:0012437)2.49999071
81Intestinal atresia (HP:0011100)2.46392530
82Congenital primary aphakia (HP:0007707)2.46248356
83Lactic acidosis (HP:0003128)2.42039349
84Cholelithiasis (HP:0001081)2.40759711
85Pancreatic islet-cell hyperplasia (HP:0004510)2.40345767
86Gout (HP:0001997)2.40016757
87Hypothermia (HP:0002045)2.39728540
88Vascular calcification (HP:0004934)2.36017164
89Mitral stenosis (HP:0001718)2.34612436
903-Methylglutaconic aciduria (HP:0003535)2.34601378
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34426883
92Abnormality of alanine metabolism (HP:0010916)2.34426883
93Hyperalaninemia (HP:0003348)2.34426883
94Neonatal onset (HP:0003623)2.34380399
95Gait imbalance (HP:0002141)2.33895170
96Generalized aminoaciduria (HP:0002909)2.31879821
97Nephrogenic diabetes insipidus (HP:0009806)2.31580972
98Cholecystitis (HP:0001082)2.28973952
99Abnormal gallbladder physiology (HP:0012438)2.28973952
100Short tibia (HP:0005736)2.27597289
101Irritability (HP:0000737)2.27173483
102Abnormality of the renal cortex (HP:0011035)2.24776351
103Spastic diplegia (HP:0001264)2.24335931
104Brushfield spots (HP:0001088)2.23799624
105Hyperinsulinemic hypoglycemia (HP:0000825)2.22580032
106Sensorimotor neuropathy (HP:0007141)2.20387898
107Increased serum lactate (HP:0002151)2.19889630
108Gingival bleeding (HP:0000225)2.19669558
109Respiratory failure (HP:0002878)2.19417506
110Renal cortical cysts (HP:0000803)2.18413489
111Pancreatitis (HP:0001733)2.18229599
112CNS demyelination (HP:0007305)2.17768092
113Male pseudohermaphroditism (HP:0000037)2.16734782
114Late onset (HP:0003584)2.16180152
115Enlarged kidneys (HP:0000105)2.15502213
116Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13319026
117Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13319026
118Aplasia/Hypoplasia of the tibia (HP:0005772)2.13034704
119Amyloidosis (HP:0011034)2.12295955
120Glomerulonephritis (HP:0000099)2.11474600
121Methylmalonic aciduria (HP:0012120)2.10306904
122Vomiting (HP:0002013)2.09549014
123Increased intramyocellular lipid droplets (HP:0012240)2.08841815
124Reduced antithrombin III activity (HP:0001976)2.08751682
125Cardiovascular calcification (HP:0011915)2.07478966
126Abnormal protein glycosylation (HP:0012346)2.06908897
127Abnormal glycosylation (HP:0012345)2.06908897
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06908897
129Abnormal protein N-linked glycosylation (HP:0012347)2.06908897
130Menorrhagia (HP:0000132)2.06526053
131Abolished electroretinogram (ERG) (HP:0000550)2.06023892
132Genital tract atresia (HP:0001827)2.04089558
133Abnormality of the gallbladder (HP:0005264)2.03659107
134Opisthotonus (HP:0002179)2.03209561
135Esophageal varix (HP:0002040)2.03030131
136Malnutrition (HP:0004395)2.01725555
137Abnormality of the renal medulla (HP:0100957)2.01095264
138Hyperglycemia (HP:0003074)1.99548822
139Thrombophlebitis (HP:0004418)1.99292195
140Increased serum pyruvate (HP:0003542)1.99198632
141Increased muscle lipid content (HP:0009058)1.97524260
142Abnormality of the pancreatic islet cells (HP:0006476)1.97362792
143Abnormality of endocrine pancreas physiology (HP:0012093)1.97362792
144Aplasia/Hypoplasia of the tongue (HP:0010295)1.97092632
145Colon cancer (HP:0003003)1.95676029
146Elevated hepatic transaminases (HP:0002910)1.94393143
147Leukodystrophy (HP:0002415)1.93655164
148Hyperphosphaturia (HP:0003109)1.93572061
149Hemorrhage of the eye (HP:0011885)1.93523762
150Optic disc pallor (HP:0000543)1.91841535
151Vaginal atresia (HP:0000148)1.91203006
152Poikilocytosis (HP:0004447)1.90684470
153Abnormality of iron homeostasis (HP:0011031)1.87515442
154Abnormal enzyme/coenzyme activity (HP:0012379)1.87501763
155Abnormality of vitamin B metabolism (HP:0004340)1.86220182
156Abnormality of transition element cation homeostasis (HP:0011030)1.84700093
157Exercise intolerance (HP:0003546)1.83875169
158Sclerocornea (HP:0000647)1.83740885
159Rickets (HP:0002748)1.83564906
160Cerebral hypomyelination (HP:0006808)1.83341398
161Symptomatic seizures (HP:0011145)1.82490773
162Abnormal ciliary motility (HP:0012262)1.82271401
163Exertional dyspnea (HP:0002875)1.81879460
164Hydroxyprolinuria (HP:0003080)1.81683951
165Abnormality of proline metabolism (HP:0010907)1.81683951
166Postaxial foot polydactyly (HP:0001830)1.81280919
167Abnormal cartilage morphology (HP:0002763)1.80635083
168Abnormality of renal resorption (HP:0011038)1.80077642
169Hypomagnesemia (HP:0002917)1.77517219
170Polydipsia (HP:0001959)1.74109305
171Abnormal drinking behavior (HP:0030082)1.74109305
172Hypophosphatemic rickets (HP:0004912)1.73550128
173Acute hepatic failure (HP:0006554)1.73338591
174Abnormality of vitamin metabolism (HP:0100508)1.72647855
175Proximal tubulopathy (HP:0000114)1.71631992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.77963772
2ERN14.57645298
3MAP4K24.28511791
4FGFR44.24327332
5SIK14.18485428
6TAOK33.76167229
7ERBB43.72426407
8INSRR3.60028265
9ZAK2.68689309
10TRIM282.65054845
11WNK32.64688861
12VRK22.46578355
13BMPR1B2.25165109
14MAPK112.21944935
15VRK12.14987292
16MAP3K42.12080829
17MAP2K42.06652918
18FLT31.88643282
19MST1R1.86548039
20MST41.86031152
21PIK3CG1.82075178
22LATS11.80248027
23NUAK11.74511554
24TNIK1.70146645
25TRIB31.65679282
26TXK1.64130193
27TYK21.62475097
28STK161.57542782
29PKN21.55983088
30NEK91.53883006
31FRK1.53589661
32MUSK1.48440013
33CASK1.48371206
34EIF2AK31.47902696
35ADRBK21.44275051
36PINK11.40227873
37PASK1.39597179
38BRSK21.35148611
39ABL21.35064681
40PLK31.33294682
41PRKAA21.32653717
42JAK21.30538461
43KDR1.26809013
44MAP3K71.25574836
45STK38L1.24149656
46LIMK11.23897946
47MAPK151.20612206
48IRAK31.19660190
49FGFR21.18694665
50TLK11.13600701
51PTK61.12634799
52MAP3K141.12322525
53STK31.11417047
54TIE11.09020955
55ERBB21.08228195
56ACVR1B1.08104788
57JAK11.07817184
58TBK11.07573108
59EPHA30.96655562
60DAPK20.95484377
61MARK30.95455658
62MAP2K30.92894825
63MAPK40.92734396
64ERBB30.91671413
65RPS6KA40.88633082
66CSNK1G30.84898816
67BCR0.84363367
68CDK190.84345787
69TGFBR10.84058114
70MAP3K30.82035590
71WEE10.81553301
72WNK40.80549692
73PRKAA10.77878956
74MAP2K70.77342234
75TTK0.77220451
76NEK10.77088620
77GRK60.76739067
78MAPK120.76658519
79PLK10.76447418
80NME10.76226837
81CAMK2G0.75371473
82CAMK1D0.75162403
83CDK30.73398717
84PAK30.72954154
85EPHB10.72370269
86DYRK20.71745456
87STK40.71576858
88PRKCZ0.70300737
89CSNK1G20.70251731
90PRKCG0.68976403
91PDK20.68631065
92TESK20.68508300
93PRKACG0.68413212
94MAP3K60.67748710
95PKN10.67082209
96PRKCE0.66219919
97BUB10.65683879
98MAPK130.63066704
99FGFR30.62943207
100IKBKE0.62357981
101OXSR10.60874815
102TGFBR20.60258052
103SGK30.59330413
104GRK70.59315926
105CDK60.58902677
106MINK10.57778524
107RPS6KA50.57129429
108MET0.57053311
109CSF1R0.56919565
110SGK20.56587838
111PLK20.56513319
112MAP3K130.55697835
113GSK3A0.55148234
114CAMKK20.54177621
115ADRBK10.53432977
116CAMK2D0.53025047
117MAP2K60.52347955
118MAP3K110.50934628
119NEK20.50679266
120PHKG10.50406935
121PHKG20.50406935
122MAP3K100.50099113
123PRKCQ0.49854153
124GRK10.49771847
125DYRK1B0.49721981
126MAP3K120.48917828
127CSNK1A1L0.48848456
128MKNK20.48427126
129STK390.48247816
130MAPK70.48069748
131PIK3CA0.46915609
132MAP3K50.46278068
133PRKACA0.46235883
134IGF1R0.45901983
135PDPK10.45901697
136SRPK10.45537909
137KIT0.45414270
138CSK0.45334279
139CSNK1G10.44201712
140CSNK2A10.42128138
141ATR0.41937800
142PDK30.41647782
143PDK40.41647782
144CSNK1A10.40563755
145PRKG10.40056852
146NTRK30.40024522
147CAMK10.39736094
148EPHA40.39717037
149IRAK10.38197934
150RIPK10.36801917
151CSNK2A20.36772922
152ATM0.36392853
153CDK40.35681326
154MAP3K10.35480997
155TAOK20.34991105
156TESK10.34637993
157OBSCN0.34300637
158SGK4940.34282167
159SGK2230.34282167
160PBK0.33415791
161MYLK0.32058632
162MAP2K10.30914814
163NLK0.30535333
164CAMK40.28517721
165RET0.27283165
166EGFR0.26839450
167ABL10.26273579
168BTK0.25869551
169ITK0.25324893
170PDK10.24400163
171PTK20.23802501
172TEC0.23608872
173IRAK20.22989326
174PRKCA0.22432112
175JAK30.21612272
176MTOR0.21418875

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.75296509
2Nitrogen metabolism_Homo sapiens_hsa009103.35634751
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27997457
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15141042
5Oxidative phosphorylation_Homo sapiens_hsa001902.98959586
6Arginine biosynthesis_Homo sapiens_hsa002202.94574933
7Complement and coagulation cascades_Homo sapiens_hsa046102.81124939
8Tryptophan metabolism_Homo sapiens_hsa003802.77937717
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61441549
10Fatty acid degradation_Homo sapiens_hsa000712.59644413
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55309048
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48913186
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48181876
14Parkinsons disease_Homo sapiens_hsa050122.34950059
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.14746982
16* Peroxisome_Homo sapiens_hsa041462.13922220
17Butanoate metabolism_Homo sapiens_hsa006502.11238081
18Propanoate metabolism_Homo sapiens_hsa006402.06834374
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04412877
20Proteasome_Homo sapiens_hsa030501.96793484
21PPAR signaling pathway_Homo sapiens_hsa033201.92239781
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.91549977
23Histidine metabolism_Homo sapiens_hsa003401.88818581
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88012360
25Fatty acid metabolism_Homo sapiens_hsa012121.87129703
26Caffeine metabolism_Homo sapiens_hsa002321.87101073
27Chemical carcinogenesis_Homo sapiens_hsa052041.84767408
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.81295437
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.71855714
30beta-Alanine metabolism_Homo sapiens_hsa004101.71193546
31Staphylococcus aureus infection_Homo sapiens_hsa051501.70786206
32Retinol metabolism_Homo sapiens_hsa008301.69676156
33RNA polymerase_Homo sapiens_hsa030201.69626797
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64784356
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64028830
36Selenocompound metabolism_Homo sapiens_hsa004501.63456365
37Ribosome_Homo sapiens_hsa030101.60134053
38Huntingtons disease_Homo sapiens_hsa050161.59412487
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57624513
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54550632
41Phenylalanine metabolism_Homo sapiens_hsa003601.53824888
42Tyrosine metabolism_Homo sapiens_hsa003501.49236488
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43882300
44Bile secretion_Homo sapiens_hsa049761.41197658
45Pyruvate metabolism_Homo sapiens_hsa006201.41036248
46Fatty acid elongation_Homo sapiens_hsa000621.40711091
47Sulfur metabolism_Homo sapiens_hsa009201.40017568
48Alzheimers disease_Homo sapiens_hsa050101.37455601
49Starch and sucrose metabolism_Homo sapiens_hsa005001.31123982
50Folate biosynthesis_Homo sapiens_hsa007901.30653188
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.29267873
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.23660540
53ABC transporters_Homo sapiens_hsa020101.22293646
54Basal transcription factors_Homo sapiens_hsa030221.20178237
55Fanconi anemia pathway_Homo sapiens_hsa034601.20174563
56Homologous recombination_Homo sapiens_hsa034401.19525039
57Steroid biosynthesis_Homo sapiens_hsa001001.18191386
58Vitamin B6 metabolism_Homo sapiens_hsa007501.15629160
59Carbon metabolism_Homo sapiens_hsa012001.14835578
60Biosynthesis of amino acids_Homo sapiens_hsa012301.12943287
61Fat digestion and absorption_Homo sapiens_hsa049751.10264771
62Cardiac muscle contraction_Homo sapiens_hsa042601.09538367
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05173439
64RNA degradation_Homo sapiens_hsa030181.03445762
65Sulfur relay system_Homo sapiens_hsa041220.99428039
66Phototransduction_Homo sapiens_hsa047440.98271749
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97475853
68Non-homologous end-joining_Homo sapiens_hsa034500.96832680
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94458099
70Mismatch repair_Homo sapiens_hsa034300.92760485
71Arginine and proline metabolism_Homo sapiens_hsa003300.90006650
72Collecting duct acid secretion_Homo sapiens_hsa049660.88934618
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.82336435
74Purine metabolism_Homo sapiens_hsa002300.82084382
75Lysine degradation_Homo sapiens_hsa003100.80442437
76Vitamin digestion and absorption_Homo sapiens_hsa049770.79231137
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78280651
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74312019
79One carbon pool by folate_Homo sapiens_hsa006700.73833803
80Pyrimidine metabolism_Homo sapiens_hsa002400.73822765
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69793175
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67891437
83Glycerolipid metabolism_Homo sapiens_hsa005610.66798450
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63511072
85Glutathione metabolism_Homo sapiens_hsa004800.63082244
86Fatty acid biosynthesis_Homo sapiens_hsa000610.62093111
87Olfactory transduction_Homo sapiens_hsa047400.60973676
88Nucleotide excision repair_Homo sapiens_hsa034200.60730371
89Pentose phosphate pathway_Homo sapiens_hsa000300.53735264
90DNA replication_Homo sapiens_hsa030300.53656301
91Prion diseases_Homo sapiens_hsa050200.52872838
92Metabolic pathways_Homo sapiens_hsa011000.49516958
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47313855
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45278497
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42715458
96Primary immunodeficiency_Homo sapiens_hsa053400.35232439
97Insulin secretion_Homo sapiens_hsa049110.32775065
98RNA transport_Homo sapiens_hsa030130.32403773
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32263029
100Galactose metabolism_Homo sapiens_hsa000520.30481580
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29213452
102Insulin resistance_Homo sapiens_hsa049310.27474402
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.27009521
104Linoleic acid metabolism_Homo sapiens_hsa005910.23268858
105Fructose and mannose metabolism_Homo sapiens_hsa000510.22139692
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.18918646
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14744954
108Glucagon signaling pathway_Homo sapiens_hsa049220.14635130
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07220207
110AMPK signaling pathway_Homo sapiens_hsa041520.05232086
111Ovarian steroidogenesis_Homo sapiens_hsa049130.01610010
112Protein export_Homo sapiens_hsa03060-0.2266232
113Circadian rhythm_Homo sapiens_hsa04710-0.2247748
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2238570
115Amoebiasis_Homo sapiens_hsa05146-0.2206551
116Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2206486
117Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2166719
118Ether lipid metabolism_Homo sapiens_hsa00565-0.2078001
119African trypanosomiasis_Homo sapiens_hsa05143-0.2077006
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1966036
121Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1577873
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1449202
123Hepatitis C_Homo sapiens_hsa05160-0.1446896
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1370631
125Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1182735
126Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1105188
127Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1076752
128Insulin signaling pathway_Homo sapiens_hsa04910-0.0701663
129Regulation of autophagy_Homo sapiens_hsa04140-0.0466117
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0391955

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