NUDT8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)6.18289753
2sarcomere organization (GO:0045214)6.04312084
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.40833870
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.32285901
5tricarboxylic acid cycle (GO:0006099)5.27967799
6cardiac myofibril assembly (GO:0055003)5.21194762
7respiratory electron transport chain (GO:0022904)5.15688307
8energy coupled proton transport, down electrochemical gradient (GO:0015985)5.10928031
9ATP synthesis coupled proton transport (GO:0015986)5.10928031
10electron transport chain (GO:0022900)5.01583123
11oxidative phosphorylation (GO:0006119)4.84650735
12heart contraction (GO:0060047)4.74584223
13heart process (GO:0003015)4.74584223
14myofibril assembly (GO:0030239)4.73688486
15regulation of mitochondrial translation (GO:0070129)4.56545716
16regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.53510781
17protein maturation by protein folding (GO:0022417)4.52985718
18fatty acid beta-oxidation (GO:0006635)4.49678272
19telomere maintenance via semi-conservative replication (GO:0032201)4.41864314
20actin-myosin filament sliding (GO:0033275)4.37566663
21muscle filament sliding (GO:0030049)4.37566663
22cardiac muscle contraction (GO:0060048)4.37500287
23DNA strand elongation involved in DNA replication (GO:0006271)4.36860227
24ribosomal small subunit biogenesis (GO:0042274)4.35974738
252-oxoglutarate metabolic process (GO:0006103)4.31436650
26bundle of His cell to Purkinje myocyte communication (GO:0086069)4.31345931
27lysine metabolic process (GO:0006553)4.29818209
28lysine catabolic process (GO:0006554)4.29818209
29branched-chain amino acid catabolic process (GO:0009083)4.29256176
30DNA strand elongation (GO:0022616)4.26333547
31nucleobase-containing small molecule interconversion (GO:0015949)4.25544846
32creatine metabolic process (GO:0006600)4.15637579
33regulation of actin filament-based movement (GO:1903115)4.14345965
34DNA unwinding involved in DNA replication (GO:0006268)4.13968990
35pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.11745753
36regulation of relaxation of muscle (GO:1901077)4.11356872
37carnitine shuttle (GO:0006853)4.09760513
38branched-chain amino acid metabolic process (GO:0009081)4.08563614
39proline biosynthetic process (GO:0006561)4.07632480
40ubiquinone biosynthetic process (GO:0006744)4.06200828
41quinone biosynthetic process (GO:1901663)4.06200828
42cardiac muscle tissue morphogenesis (GO:0055008)4.06182836
43ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.04712101
44aspartate family amino acid catabolic process (GO:0009068)4.03561337
452-deoxyribonucleotide biosynthetic process (GO:0009265)3.99545237
46deoxyribose phosphate biosynthetic process (GO:0046385)3.99545237
47regulation of acyl-CoA biosynthetic process (GO:0050812)3.98335903
48base-excision repair, AP site formation (GO:0006285)3.97718988
49glyoxylate metabolic process (GO:0046487)3.94036755
50cardiac muscle cell development (GO:0055013)3.92308579
51fatty acid catabolic process (GO:0009062)3.89889199
52pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.88372936
53pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.87580556
54negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.84103056
55GDP-mannose metabolic process (GO:0019673)3.83850588
56regulation of translational fidelity (GO:0006450)3.81692326
57fatty acid transmembrane transport (GO:1902001)3.78901916
58valine metabolic process (GO:0006573)3.76967506
59regulation of skeletal muscle contraction (GO:0014819)3.76337146
60adult heart development (GO:0007512)3.74959955
61fatty acid oxidation (GO:0019395)3.73377248
62viral transcription (GO:0019083)3.73168182
63ribosomal small subunit assembly (GO:0000028)3.72263053
64guanosine-containing compound biosynthetic process (GO:1901070)3.71077056
65folic acid metabolic process (GO:0046655)3.69534933
66cardiac cell development (GO:0055006)3.67468262
67short-chain fatty acid metabolic process (GO:0046459)3.66538772
68lipid oxidation (GO:0034440)3.66254503
69erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.65999960
70L-phenylalanine metabolic process (GO:0006558)3.65999960
71pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.64880463
72regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.64577909
73regulation of coenzyme metabolic process (GO:0051196)3.62769605
74regulation of cofactor metabolic process (GO:0051193)3.62769605
75tricarboxylic acid metabolic process (GO:0072350)3.62727757
76acetyl-CoA metabolic process (GO:0006084)3.62510722
77ubiquinone metabolic process (GO:0006743)3.61948486
78negative regulation of potassium ion transmembrane transport (GO:1901380)3.61429477
79muscle tissue morphogenesis (GO:0060415)3.61143995
80deoxyribonucleotide catabolic process (GO:0009264)3.60975834
81regulation of sequestering of triglyceride (GO:0010889)3.58738681
82purine deoxyribonucleotide catabolic process (GO:0009155)3.58252603
83regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.56853959
84cellular ketone body metabolic process (GO:0046950)3.56819108
85mitochondrial respiratory chain complex I assembly (GO:0032981)3.55847068
86NADH dehydrogenase complex assembly (GO:0010257)3.55847068
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55847068
88deoxyribose phosphate catabolic process (GO:0046386)3.55303250
89ventricular cardiac muscle cell action potential (GO:0086005)3.53046398
90response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.51021211
91translational termination (GO:0006415)3.50863688
92UTP biosynthetic process (GO:0006228)3.50581373
93actin-mediated cell contraction (GO:0070252)3.50385962
94aerobic respiration (GO:0009060)3.49245842
95telomere maintenance via recombination (GO:0000722)3.48958466
96GTP biosynthetic process (GO:0006183)3.47465073
97NADH metabolic process (GO:0006734)3.43716404
98monocarboxylic acid catabolic process (GO:0072329)3.43329725
99deoxyribonucleotide biosynthetic process (GO:0009263)3.42724550
100UTP metabolic process (GO:0046051)3.41175249
101chaperone-mediated protein transport (GO:0072321)3.39624348
102positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.38044883
103actomyosin structure organization (GO:0031032)3.36720631
104translational elongation (GO:0006414)3.36323769
105cardiac muscle hypertrophy (GO:0003300)3.36028040
106negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.35336385
107succinate metabolic process (GO:0006105)3.33389056
108protein complex biogenesis (GO:0070271)3.31934846
109pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.30259115
110oxaloacetate metabolic process (GO:0006107)3.29776056
111regulation of sarcomere organization (GO:0060297)3.28853427
112pseudouridine synthesis (GO:0001522)3.28170460
113CTP metabolic process (GO:0046036)3.26863947
114CTP biosynthetic process (GO:0006241)3.26863947
115regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.26426795
116erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.26259083
117L-phenylalanine catabolic process (GO:0006559)3.26259083
118pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.24397880
119pyrimidine nucleotide catabolic process (GO:0006244)3.22783650
120heart trabecula formation (GO:0060347)3.20771773
121mitotic recombination (GO:0006312)3.17481761
122striated muscle contraction (GO:0006941)3.17237692
123deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.14281263
124pentose metabolic process (GO:0019321)3.13283127
1252-deoxyribonucleotide metabolic process (GO:0009394)3.12057213
126amino-acid betaine transport (GO:0015838)3.10624248
127carnitine transport (GO:0015879)3.10624248
128striated muscle hypertrophy (GO:0014897)3.10459542
129mitochondrial calcium ion transport (GO:0006851)3.09503719
130purine nucleotide salvage (GO:0032261)3.09445322
131regulation of ATP catabolic process (GO:1903289)3.08712211
132regulation of ATPase activity (GO:0043462)3.08712211
133SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08454692
134mitochondrial respiratory chain complex assembly (GO:0033108)3.08347121
135regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.08096230
136negative regulation of B cell apoptotic process (GO:0002903)3.07944635
137carnitine transmembrane transport (GO:1902603)3.07933694
138gluconeogenesis (GO:0006094)3.07345658
139carnitine metabolic process (GO:0009437)3.06074451
140fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.05561263
141base-excision repair (GO:0006284)3.05417540
142negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.05115175
143negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.04946884
144regulation of striated muscle contraction (GO:0006942)3.03521527
145prostanoid biosynthetic process (GO:0046457)3.03464685
146prostaglandin biosynthetic process (GO:0001516)3.03464685
147quaternary ammonium group transport (GO:0015697)3.03295484
148ATP biosynthetic process (GO:0006754)3.02679428
149nucleotide salvage (GO:0043173)3.02367248
150biotin metabolic process (GO:0006768)3.02235808
151ketone body metabolic process (GO:1902224)3.01612821
152protein targeting to ER (GO:0045047)3.00229807
153deoxyribose phosphate metabolic process (GO:0019692)2.99425209
154cotranslational protein targeting to membrane (GO:0006613)2.98987554
155monosaccharide biosynthetic process (GO:0046364)2.98859874
156ethanol oxidation (GO:0006069)2.98265526
157proline metabolic process (GO:0006560)2.95671645
158hexose biosynthetic process (GO:0019319)2.94119946
159kynurenine metabolic process (GO:0070189)2.92889994
160protein retention in ER lumen (GO:0006621)2.92596403
161folic acid-containing compound biosynthetic process (GO:0009396)2.92372025
162protein localization to endoplasmic reticulum (GO:0070972)2.92205509
163regulation of sulfur metabolic process (GO:0042762)2.91459854
164viral life cycle (GO:0019058)2.91218142
165nucleotide-excision repair, DNA gap filling (GO:0006297)2.90374483
166maturation of SSU-rRNA (GO:0030490)2.87930366
167regulation of cell communication by electrical coupling (GO:0010649)2.87657593
168DNA replication initiation (GO:0006270)2.86282443
169establishment of protein localization to endoplasmic reticulum (GO:0072599)2.86273988
170pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.86155931
171mitochondrial fusion (GO:0008053)2.86110643
172pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.85340667
173ribonucleoprotein complex biogenesis (GO:0022613)2.84971525
174muscle hypertrophy (GO:0014896)2.84087497
175nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.83818499
176post-embryonic morphogenesis (GO:0009886)2.83068978
177protein targeting to mitochondrion (GO:0006626)2.82693208
178nucleoside diphosphate biosynthetic process (GO:0009133)2.79776298
179deoxyribonucleotide metabolic process (GO:0009262)2.79550700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.67570114
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.92285507
3E2F7_22180533_ChIP-Seq_HELA_Human4.45896755
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.31857633
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.20533059
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.03269541
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.94245730
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.86874010
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69128271
10* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.64306581
11SRF_21415370_ChIP-Seq_HL-1_Mouse2.61161924
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55049461
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.44466533
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28998745
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.22310755
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16895064
17CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.12500553
18EGR1_23403033_ChIP-Seq_LIVER_Mouse2.08710405
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.07837936
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.04465110
21GATA1_22025678_ChIP-Seq_K562_Human2.04449962
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97298944
23* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94168269
24MYC_22102868_ChIP-Seq_BL_Human1.93536034
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.93150459
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.90987630
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.90289927
28* LXR_22292898_ChIP-Seq_THP-1_Human1.85974248
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.84956912
30PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.84262144
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83097459
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81034971
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78425433
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.77436693
35* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77043013
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.74956232
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74125154
38* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.73700191
39GATA4_21415370_ChIP-Seq_HL-1_Mouse1.71470489
40GABP_19822575_ChIP-Seq_HepG2_Human1.70146019
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69843729
42DCP1A_22483619_ChIP-Seq_HELA_Human1.68563998
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67908076
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67418203
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67044525
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65787837
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64147674
48ZNF263_19887448_ChIP-Seq_K562_Human1.64132302
49TBX20_22328084_ChIP-Seq_HEART_Mouse1.62102462
50TBX20_22080862_ChIP-Seq_HEART_Mouse1.62102462
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60521735
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58288449
53RACK7_27058665_Chip-Seq_MCF-7_Human1.57747003
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.57447378
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57059738
56MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.54288121
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.52979617
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.52135569
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52053582
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51713853
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.50294568
62* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49778201
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48553891
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45934542
65P68_20966046_ChIP-Seq_HELA_Human1.45590768
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45528154
67CIITA_25753668_ChIP-Seq_RAJI_Human1.43498063
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42705483
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.42370701
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40764065
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.40179407
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40149596
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38296404
74VDR_21846776_ChIP-Seq_THP-1_Human1.37026351
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34244064
76TTF2_22483619_ChIP-Seq_HELA_Human1.33358431
77AR_21909140_ChIP-Seq_LNCAP_Human1.32931835
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30808977
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30598310
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.30015336
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.29712743
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29601100
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.29216831
84FOXP3_21729870_ChIP-Seq_TREG_Human1.29034574
85KDM5A_27292631_Chip-Seq_BREAST_Human1.28976115
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28668906
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28338966
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25267118
89MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25247758
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.24466907
91CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24376178
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.24277404
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22312120
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21930473
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21317348
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.20967995
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20764147
98XRN2_22483619_ChIP-Seq_HELA_Human1.20754779
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20541628
100E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20540047
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20516136
102TP63_17297297_ChIP-ChIP_HaCaT_Human1.20416416
103MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20092724
104NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.19858140
105* FOXP1_21924763_ChIP-Seq_HESCs_Human1.19679873
106* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.19502345
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18143681
108EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17793272
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17009913
110EP300_21415370_ChIP-Seq_HL-1_Mouse1.16253345
111GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15895620
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15607241
113BCL6_27268052_Chip-Seq_Bcells_Human1.15548895
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15048231
115* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14868129
116BCOR_27268052_Chip-Seq_Bcells_Human1.14279463
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13957611
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12855882
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11191370
120* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10020145
121LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08168707
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07079120
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06500302
124SCL_19346495_ChIP-Seq_HPC-7_Human1.05113233
125CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04351501
126* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03390272
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02542065
128* CTCF_21964334_Chip-Seq_Bcells_Human1.02347737
129ATF3_27146783_Chip-Seq_COLON_Human1.01922675
130HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01752991
131VDR_23849224_ChIP-Seq_CD4+_Human1.00700937
132* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00544851
133YY1_22570637_ChIP-Seq_MALME-3M_Human1.00086204
134ELK1_22589737_ChIP-Seq_MCF10A_Human0.99470989
135CTCF_26484167_Chip-Seq_Bcells_Mouse0.99169556
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.99113502
137MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98766063
138MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97633972
139CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96234469
140* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96183456
141GATA1_19941827_ChIP-Seq_MEL_Mouse0.95919558
142IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95871624
143MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94416528
144* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94144852
145SPI1_20517297_ChIP-Seq_HL60_Human0.93689532
146* TET1_21451524_ChIP-Seq_MESCs_Mouse0.93498693
147SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92328477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.55816116
2MP0003646_muscle_fatigue5.17340035
3MP0004084_abnormal_cardiac_muscle4.29122097
4MP0000751_myopathy4.06842705
5MP0004215_abnormal_myocardial_fiber3.82422163
6MP0005330_cardiomyopathy3.54917424
7MP0000749_muscle_degeneration3.41139122
8MP0004036_abnormal_muscle_relaxation3.18928149
9MP0003693_abnormal_embryo_hatching2.97994150
10MP0003806_abnormal_nucleotide_metabolis2.84504785
11MP0010094_abnormal_chromosome_stability2.82707524
12MP0003111_abnormal_nucleus_morphology2.78108176
13MP0006036_abnormal_mitochondrial_physio2.73424334
14MP0003137_abnormal_impulse_conducting2.73320044
15MP0002972_abnormal_cardiac_muscle2.46295699
16MP0005360_urolithiasis2.45816223
17MP0004185_abnormal_adipocyte_glucose2.44907663
18MP0002139_abnormal_hepatobiliary_system2.39890712
19MP0004087_abnormal_muscle_fiber2.35053005
20MP0005385_cardiovascular_system_phenoty2.25243137
21MP0001544_abnormal_cardiovascular_syste2.25243137
22MP0002234_abnormal_pharynx_morphology2.19525786
23MP0008775_abnormal_heart_ventricle2.14214697
24MP0005085_abnormal_gallbladder_physiolo2.13876659
25MP0003077_abnormal_cell_cycle2.05885714
26MP0004957_abnormal_blastocyst_morpholog2.04828820
27MP0004858_abnormal_nervous_system2.03242199
28MP0005365_abnormal_bile_salt2.00601728
29MP0010630_abnormal_cardiac_muscle1.99720432
30MP0003828_pulmonary_edema1.99413250
31MP0006138_congestive_heart_failure1.99118551
32MP0002269_muscular_atrophy1.98187916
33MP0005620_abnormal_muscle_contractility1.87824808
34MP0004130_abnormal_muscle_cell1.87282349
35MP0001661_extended_life_span1.82415524
36MP0002106_abnormal_muscle_physiology1.82250114
37MP0008058_abnormal_DNA_repair1.80321113
38MP0003950_abnormal_plasma_membrane1.80134476
39MP0000678_abnormal_parathyroid_gland1.79399885
40MP0000750_abnormal_muscle_regeneration1.73506404
41MP0004484_altered_response_of1.73478611
42MP0000747_muscle_weakness1.73017625
43MP0005451_abnormal_body_composition1.72294421
44MP0005501_abnormal_skin_physiology1.66583445
45MP0005332_abnormal_amino_acid1.64471867
46MP0003221_abnormal_cardiomyocyte_apopto1.62306901
47MP0003315_abnormal_perineum_morphology1.56521329
48MP0005083_abnormal_biliary_tract1.56299752
49MP0004043_abnormal_pH_regulation1.52691231
50MP0008932_abnormal_embryonic_tissue1.50989906
51MP0003195_calcinosis1.50274317
52MP0005670_abnormal_white_adipose1.47541796
53MP0002127_abnormal_cardiovascular_syste1.45640125
54MP0002796_impaired_skin_barrier1.44365111
55MP0004085_abnormal_heartbeat1.44311063
56MP0003186_abnormal_redox_activity1.41396401
57MP0008057_abnormal_DNA_replication1.39257007
58MP0009840_abnormal_foam_cell1.39226317
59MP0005369_muscle_phenotype1.38184404
60MP0000759_abnormal_skeletal_muscle1.38169345
61MP0004147_increased_porphyrin_level1.34234155
62MP0002132_abnormal_respiratory_system1.33639208
63MP0000350_abnormal_cell_proliferation1.31295553
64MP0006035_abnormal_mitochondrial_morpho1.30437880
65MP0008007_abnormal_cellular_replicative1.27577509
66MP0000490_abnormal_crypts_of1.27549607
67MP0002019_abnormal_tumor_incidence1.27207057
68MP0010234_abnormal_vibrissa_follicle1.24832711
69MP0005076_abnormal_cell_differentiation1.24695922
70MP0003123_paternal_imprinting1.23294198
71MP0005666_abnormal_adipose_tissue1.23188465
72MP0004233_abnormal_muscle_weight1.21205879
73MP0000343_altered_response_to1.19527445
74MP0008875_abnormal_xenobiotic_pharmacok1.18365809
75MP0002163_abnormal_gland_morphology1.18154328
76MP0009643_abnormal_urine_homeostasis1.18079819
77MP0005319_abnormal_enzyme/_coenzyme1.17705062
78MP0003786_premature_aging1.17551586
79MP0003567_abnormal_fetal_cardiomyocyte1.17510481
80MP0009278_abnormal_bone_marrow1.17155800
81MP0005266_abnormal_metabolism1.15180674
82MP0005220_abnormal_exocrine_pancreas1.13698020
83MP0000313_abnormal_cell_death1.13283619
84MP0000003_abnormal_adipose_tissue1.12372021
85MP0000858_altered_metastatic_potential1.11655040
86MP0000358_abnormal_cell_content/1.05501599
87MP0001881_abnormal_mammary_gland1.04847636
88MP0005165_increased_susceptibility_to1.04700975
89MP0000613_abnormal_salivary_gland1.04370970
90MP0005584_abnormal_enzyme/coenzyme_acti1.03595187
91MP0000681_abnormal_thyroid_gland1.03579030
92MP0003656_abnormal_erythrocyte_physiolo1.01995106
93MP0001730_embryonic_growth_arrest1.01482056
94MP0002332_abnormal_exercise_endurance1.01231259
95MP0001853_heart_inflammation1.01003756
96MP0005397_hematopoietic_system_phenotyp1.00785615
97MP0001545_abnormal_hematopoietic_system1.00785615
98MP0004510_myositis1.00688378
99MP0009333_abnormal_splenocyte_physiolog0.97578601
100MP0004145_abnormal_muscle_electrophysio0.97544213
101MP0002080_prenatal_lethality0.97187914
102MP0002396_abnormal_hematopoietic_system0.96273864
103MP0003252_abnormal_bile_duct0.94818502
104MP0001764_abnormal_homeostasis0.93786907
105MP0010030_abnormal_orbit_morphology0.93744431
106MP0002166_altered_tumor_susceptibility0.92506973
107MP0002118_abnormal_lipid_homeostasis0.90521703
108MP0003279_aneurysm0.90026736
109MP0002970_abnormal_white_adipose0.89623808
110MP0008260_abnormal_autophagy0.86949875
111MP0000230_abnormal_systemic_arterial0.84706491
112MP0002249_abnormal_larynx_morphology0.83909462
113MP0009697_abnormal_copulation0.83367894
114MP0002148_abnormal_hypersensitivity_rea0.83320468
115MP0002877_abnormal_melanocyte_morpholog0.82413511
116MP0003705_abnormal_hypodermis_morpholog0.81938424
117MP0001666_abnormal_nutrient_absorption0.81698706
118MP0009379_abnormal_foot_pigmentation0.81446206
119MP0001835_abnormal_antigen_presentation0.80424320
120MP0009785_altered_susceptibility_to0.79598423
121MP0000372_irregular_coat_pigmentation0.77434956
122MP0002138_abnormal_hepatobiliary_system0.77388729
123MP0001727_abnormal_embryo_implantation0.77165156
124MP0000266_abnormal_heart_morphology0.74831157
125MP0001346_abnormal_lacrimal_gland0.74806671
126MP0001348_abnormal_lacrimal_gland0.74100051
127MP0000685_abnormal_immune_system0.73039690
128MP0000627_abnormal_mammary_gland0.72855950
129MP0000733_abnormal_muscle_development0.72707093
130MP0001529_abnormal_vocalization0.72152264
131MP0009672_abnormal_birth_weight0.71910285
132MP0005636_abnormal_mineral_homeostasis0.71187378
133MP0010329_abnormal_lipoprotein_level0.70752379
134MP0002822_catalepsy0.69460379
135MP0005384_cellular_phenotype0.69020979
136MP0000609_abnormal_liver_physiology0.68703495
137MP0001672_abnormal_embryogenesis/_devel0.68220480
138MP0005380_embryogenesis_phenotype0.68220480
139MP0008469_abnormal_protein_level0.64307510
140MP0003724_increased_susceptibility_to0.61646851
141MP0009763_increased_sensitivity_to0.60209133
142MP0005376_homeostasis/metabolism_phenot0.59578255
143MP0002078_abnormal_glucose_homeostasis0.59262853
144MP0005409_darkened_coat_color0.56350202
145MP0003011_delayed_dark_adaptation0.55932322
146MP0005058_abnormal_lysosome_morphology0.54848448
147MP0005025_abnormal_response_to0.54620022
148MP0002128_abnormal_blood_circulation0.54479316
149MP0001986_abnormal_taste_sensitivity0.53346302
150MP0005535_abnormal_body_temperature0.52495888
151MP0005084_abnormal_gallbladder_morpholo0.51913946
152MP0000598_abnormal_liver_morphology0.51604964
153MP0001790_abnormal_immune_system0.51423153
154MP0005387_immune_system_phenotype0.51423153
155MP0009642_abnormal_blood_homeostasis0.51120339
156MP0003191_abnormal_cellular_cholesterol0.50775259
157MP0005375_adipose_tissue_phenotype0.50129127
158MP0001765_abnormal_ion_homeostasis0.47516140
159MP0004019_abnormal_vitamin_homeostasis0.46925752

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.16207776
2Ventricular tachycardia (HP:0004756)5.09660355
3Hepatic necrosis (HP:0002605)4.91138268
4Hepatocellular necrosis (HP:0001404)4.53232513
5Acute necrotizing encephalopathy (HP:0006965)4.38941686
6Abnormal mitochondria in muscle tissue (HP:0008316)4.33854671
7Atrial fibrillation (HP:0005110)4.31404055
8Calf muscle hypertrophy (HP:0008981)4.29715754
9Lipoatrophy (HP:0100578)4.23294946
10Mitochondrial inheritance (HP:0001427)4.10698443
11Acute encephalopathy (HP:0006846)4.07669667
12Supraventricular tachycardia (HP:0004755)3.99332143
13Primary atrial arrhythmia (HP:0001692)3.97570881
14Muscle hypertrophy of the lower extremities (HP:0008968)3.92808000
15Abnormality of dicarboxylic acid metabolism (HP:0010995)3.92007606
16Dicarboxylic aciduria (HP:0003215)3.92007606
17Supraventricular arrhythmia (HP:0005115)3.87607169
18Progressive muscle weakness (HP:0003323)3.81072160
19Centrally nucleated skeletal muscle fibers (HP:0003687)3.80583781
20Cerebral edema (HP:0002181)3.80129019
21Myoglobinuria (HP:0002913)3.79871302
22Abnormality of fatty-acid metabolism (HP:0004359)3.73290504
23Increased CSF lactate (HP:0002490)3.70917243
24Palpitations (HP:0001962)3.63630078
25Dilated cardiomyopathy (HP:0001644)3.63209346
26Generalized aminoaciduria (HP:0002909)3.59287430
27Increased muscle lipid content (HP:0009058)3.58580607
28Exercise-induced myalgia (HP:0003738)3.55434334
29Muscle fiber splitting (HP:0003555)3.49221520
30Muscle fiber inclusion bodies (HP:0100299)3.42663632
31Progressive macrocephaly (HP:0004481)3.41408871
32Exercise-induced muscle cramps (HP:0003710)3.40851769
33Abnormality of the calf musculature (HP:0001430)3.39831835
34Lactic acidosis (HP:0003128)3.35000619
35Nemaline bodies (HP:0003798)3.34282095
36Increased intramyocellular lipid droplets (HP:0012240)3.32001440
37Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.30286689
38Right ventricular cardiomyopathy (HP:0011663)3.30166369
39Abnormality of the left ventricular outflow tract (HP:0011103)3.29139413
40Subaortic stenosis (HP:0001682)3.29139413
41Hypoglycemic coma (HP:0001325)3.25505783
42Rhabdomyolysis (HP:0003201)3.22537957
43Ketoacidosis (HP:0001993)3.20546071
44Ketosis (HP:0001946)3.18954702
45Lipid accumulation in hepatocytes (HP:0006561)3.10185693
46Hyperammonemia (HP:0001987)3.08716013
47Respiratory failure (HP:0002878)3.04829361
48Syncope (HP:0001279)3.03364755
49Exercise intolerance (HP:0003546)3.00832112
50Type I transferrin isoform profile (HP:0003642)2.99891795
51Prolonged QT interval (HP:0001657)2.94903420
52Myopathic facies (HP:0002058)2.94207101
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.93238780
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.93238780
55Abnormality of alanine metabolism (HP:0010916)2.88059565
56Hyperalaninemia (HP:0003348)2.88059565
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88059565
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.84930459
59Increased serum pyruvate (HP:0003542)2.82657700
60Abnormality of glycolysis (HP:0004366)2.82657700
61Increased serum lactate (HP:0002151)2.82264540
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.78675704
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.77427403
64Achilles tendon contracture (HP:0001771)2.77214166
65Ventricular arrhythmia (HP:0004308)2.73954283
66Asymmetric septal hypertrophy (HP:0001670)2.73256760
67Lethargy (HP:0001254)2.69759623
68Hyperglycinuria (HP:0003108)2.69237159
69Ragged-red muscle fibers (HP:0003200)2.69169977
70Proximal tubulopathy (HP:0000114)2.69059733
71Increased hepatocellular lipid droplets (HP:0006565)2.65769441
72Reduced antithrombin III activity (HP:0001976)2.60773317
73Hyporeflexia of lower limbs (HP:0002600)2.60693453
74Abnormality of serine family amino acid metabolism (HP:0010894)2.60305725
75Abnormality of glycine metabolism (HP:0010895)2.60305725
76Muscle stiffness (HP:0003552)2.57545980
77Metabolic acidosis (HP:0001942)2.53443089
78Glycosuria (HP:0003076)2.53189828
79Abnormality of urine glucose concentration (HP:0011016)2.53189828
80Abnormal number of erythroid precursors (HP:0012131)2.53157537
81Abnormality of the Achilles tendon (HP:0005109)2.52504564
82Abnormality of aromatic amino acid family metabolism (HP:0004338)2.52167719
83EMG: myopathic abnormalities (HP:0003458)2.49421402
84Abnormality of cells of the erythroid lineage (HP:0012130)2.47631967
85Testicular atrophy (HP:0000029)2.47574747
86Atrioventricular block (HP:0001678)2.47155551
87Nausea (HP:0002018)2.43225877
88Microvesicular hepatic steatosis (HP:0001414)2.42967053
89Methylmalonic aciduria (HP:0012120)2.40194588
90Heart block (HP:0012722)2.39481319
91Abnormal gallbladder physiology (HP:0012438)2.37177539
92Cholecystitis (HP:0001082)2.37177539
93Ventricular fibrillation (HP:0001663)2.36634814
94Renal Fanconi syndrome (HP:0001994)2.35536233
95Hyperthyroidism (HP:0000836)2.32980253
96Vomiting (HP:0002013)2.30202320
97Cerebral palsy (HP:0100021)2.26626856
98Abnormal atrioventricular conduction (HP:0005150)2.25353917
99Microretrognathia (HP:0000308)2.23019883
100Optic disc pallor (HP:0000543)2.21101950
101Opisthotonus (HP:0002179)2.20954362
102Seborrheic dermatitis (HP:0001051)2.19401511
103Neck muscle weakness (HP:0000467)2.18825073
104Bundle branch block (HP:0011710)2.18662426
105Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18619323
106Abnormal protein N-linked glycosylation (HP:0012347)2.18619323
107Abnormal protein glycosylation (HP:0012346)2.18619323
108Abnormal glycosylation (HP:0012345)2.18619323
109Leukodystrophy (HP:0002415)2.18497732
110Abnormality of serum amino acid levels (HP:0003112)2.17968070
111Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17607888
112Type 1 muscle fiber predominance (HP:0003803)2.17217647
113Hypertensive crisis (HP:0100735)2.16354143
1143-Methylglutaconic aciduria (HP:0003535)2.16299019
115Esophageal neoplasm (HP:0100751)2.14605002
116Neoplasm of head and neck (HP:0012288)2.14605002
117Vertebral compression fractures (HP:0002953)2.13518474
118Exertional dyspnea (HP:0002875)2.10869984
119Abnormality of skeletal muscle fiber size (HP:0012084)2.10667664
120Abnormality of the tricuspid valve (HP:0001702)2.10256149
121Methylmalonic acidemia (HP:0002912)2.09805180
122Reticulocytopenia (HP:0001896)2.09002863
123Spastic paraparesis (HP:0002313)2.08815075
124Palmoplantar keratoderma (HP:0000982)2.04552185
125Bulbar palsy (HP:0001283)2.03873272
126Gout (HP:0001997)2.03167267
127CNS demyelination (HP:0007305)2.01254613
128Left ventricular hypertrophy (HP:0001712)1.99668953
129Truncus arteriosus (HP:0001660)1.96524685
130Abnormal EKG (HP:0003115)1.96031642
131Multiple enchondromatosis (HP:0005701)1.94840510
132Hyperglycinemia (HP:0002154)1.94730791
133Trismus (HP:0000211)1.91367749
134Tinnitus (HP:0000360)1.90751074
135Hypokinesia (HP:0002375)1.90409608
136Pancytopenia (HP:0001876)1.88476985
137Emotional lability (HP:0000712)1.87372555
138Distal lower limb muscle weakness (HP:0009053)1.86981962
139Cholelithiasis (HP:0001081)1.86535678
140Deformed tarsal bones (HP:0008119)1.86090112
141Myotonia (HP:0002486)1.85323965
142Areflexia of lower limbs (HP:0002522)1.83683318
143Calcaneovalgus deformity (HP:0001848)1.83626656
144Abnormality of reticulocytes (HP:0004312)1.82976967
145Rough bone trabeculation (HP:0100670)1.82770974
146Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82373388
147Increased connective tissue (HP:0009025)1.82280348
148Abnormality of the umbilical cord (HP:0010881)1.81752713
149Conjunctival hamartoma (HP:0100780)1.81424263
150Fasciculations (HP:0002380)1.78072984
151Reticulocytosis (HP:0001923)1.70648911
152Macrocytic anemia (HP:0001972)1.70107184
153Generalized amyotrophy (HP:0003700)1.69722201
154Hypoparathyroidism (HP:0000829)1.68329057
155Increased variability in muscle fiber diameter (HP:0003557)1.68011477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.33199088
2SCYL24.15319601
3VRK24.01255124
4TTN4.00014412
5MYLK3.68583281
6NME23.59815490
7OBSCN2.79220090
8SMG12.59867224
9BUB12.55616336
10ARAF2.48023076
11LMTK22.39988452
12PKN22.37466110
13TESK22.31840682
14TESK12.30966164
15PHKG22.27079349
16PHKG12.27079349
17IRAK32.17315492
18CDC72.12475366
19EPHA22.08753130
20TIE12.02001897
21MUSK2.00165627
22STK161.85678097
23WNK41.83459151
24PIM21.72509572
25PINK11.71062050
26FLT31.58611246
27PDK31.55657632
28PDK41.55657632
29STK41.55250345
30MAP4K11.51707597
31ICK1.50850439
32TRIB31.50170683
33KDR1.45368079
34EEF2K1.44061651
35PIK3CA1.43804759
36MAPKAPK31.41400431
37TLK11.40252413
38EIF2AK11.39024451
39RPS6KB21.36229208
40TBK11.34392140
41EPHB11.30865279
42ILK1.27234832
43CDK81.26029309
44STK241.25336477
45CDK71.24332317
46ZAK1.23340446
47STK391.21626429
48NLK1.20748415
49SIK11.19950118
50TRPM71.19749928
51AURKA1.18193692
52NEK11.17920728
53DMPK1.17688249
54MAP3K111.12565114
55PBK1.12460325
56GRK71.07026266
57PKN11.06186954
58ERN11.04585880
59PRKAA21.02328359
60BRAF1.01908339
61TAOK21.00552128
62LRRK21.00126907
63CAMK2D0.99861326
64MAP3K70.99502085
65PRPF4B0.99320296
66EIF2AK30.98240403
67DAPK30.95397662
68TYK20.95048007
69CHEK20.94599749
70TEC0.92432470
71PRKD10.87052434
72CCNB10.86655804
73MST40.85451545
74DAPK10.85403045
75PAK30.84497466
76MAP2K30.82724390
77MAP3K140.79398165
78PRKD30.79339417
79CLK10.78795611
80AURKB0.78716511
81NME10.75771249
82PRKCI0.75549083
83RAF10.74990480
84IRAK40.73969988
85BTK0.70785331
86MAPK110.69326554
87TNIK0.69015627
88ATR0.68575283
89MAPK120.68441996
90STK38L0.67969329
91AKT20.67590264
92ABL20.66315485
93MAP3K80.65105828
94BRSK10.63973761
95TTK0.62598114
96FGFR40.62492807
97PDK20.62379843
98LIMK10.62186634
99KIT0.62167241
100RPS6KL10.62067044
101RPS6KC10.62067044
102RPS6KA40.61757008
103MAP2K60.60020324
104MAP3K30.59466332
105RPS6KA60.58833195
106MST1R0.57007956
107PLK10.56747907
108TXK0.56267768
109JAK10.56061218
110WEE10.55710031
111IRAK20.52443380
112TNK20.52323333
113IKBKB0.52190540
114MAP3K50.51691605
115SRPK10.51202552
116ROCK20.50836393
117OXSR10.50520685
118PAK40.50361351
119GRK10.49922345
120PIK3CG0.49732826
121CAMK10.48934535
122CAMK2G0.48932255
123TAF10.48661719
124VRK10.48374491
125CDK40.47852473
126TGFBR20.46371955
127PRKAA10.45499369
128IRAK10.45129617
129INSRR0.44913236
130BLK0.43756396
131ITK0.43004852
132CSNK1G30.40956704
133GRK60.40662739
134PRKG20.40618189
135CSNK2A20.40472216
136PRKCQ0.40231062
137RPS6KA50.40078450
138ROCK10.39375623
139IKBKE0.39292459
140CAMK40.39282344
141PRKACA0.38477268
142CDK190.37795166
143CSF1R0.37750041
144CHEK10.37099071
145DYRK1B0.35760631
146PRKCD0.34024028
147CDK90.33189037
148ADRBK20.33074194
149PAK10.32917518
150CSNK2A10.32851825
151PRKACB0.31627059
152NEK20.31623037
153JAK30.31279117
154CDK20.28323976
155TAOK10.27271625
156EIF2AK20.26299963
157MTOR0.24649124
158MAPK40.23792846
159PRKD20.23742460
160CSNK1A1L0.22520886
161CDK11A0.22292187

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.82700745
2Propanoate metabolism_Homo sapiens_hsa006403.35693908
3Oxidative phosphorylation_Homo sapiens_hsa001903.25272852
4Parkinsons disease_Homo sapiens_hsa050123.17644782
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.16750045
6Fatty acid degradation_Homo sapiens_hsa000713.12155506
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.03243718
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.60292014
9Cardiac muscle contraction_Homo sapiens_hsa042602.47614600
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42874973
11Fatty acid elongation_Homo sapiens_hsa000622.40883526
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33904619
13Fatty acid metabolism_Homo sapiens_hsa012122.29538761
14Carbon metabolism_Homo sapiens_hsa012002.19404168
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.15239870
16Butanoate metabolism_Homo sapiens_hsa006502.14656950
17Alzheimers disease_Homo sapiens_hsa050102.14038985
18Peroxisome_Homo sapiens_hsa041461.94741501
19Ribosome_Homo sapiens_hsa030101.89888698
20Huntingtons disease_Homo sapiens_hsa050161.88122802
21Tryptophan metabolism_Homo sapiens_hsa003801.86567149
22Pyruvate metabolism_Homo sapiens_hsa006201.80865854
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72931235
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.51138404
25beta-Alanine metabolism_Homo sapiens_hsa004101.50663883
26Folate biosynthesis_Homo sapiens_hsa007901.43837092
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41671859
28Fanconi anemia pathway_Homo sapiens_hsa034601.39997599
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37278779
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.35772962
31Dilated cardiomyopathy_Homo sapiens_hsa054141.32934950
32DNA replication_Homo sapiens_hsa030301.31631250
33Biosynthesis of amino acids_Homo sapiens_hsa012301.28645115
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.28423730
35Arginine and proline metabolism_Homo sapiens_hsa003301.23049122
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20670745
37Spliceosome_Homo sapiens_hsa030401.18214553
38PPAR signaling pathway_Homo sapiens_hsa033201.15946959
39Vitamin B6 metabolism_Homo sapiens_hsa007501.15843640
40Protein export_Homo sapiens_hsa030601.14663114
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13241740
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07413138
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04310289
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02262096
45Sulfur metabolism_Homo sapiens_hsa009201.01850886
46Mismatch repair_Homo sapiens_hsa034300.99222977
47Sulfur relay system_Homo sapiens_hsa041220.97716280
48Starch and sucrose metabolism_Homo sapiens_hsa005000.96397232
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.96207156
50Arginine biosynthesis_Homo sapiens_hsa002200.89161666
51Metabolic pathways_Homo sapiens_hsa011000.88780810
52Selenocompound metabolism_Homo sapiens_hsa004500.88122309
53Pyrimidine metabolism_Homo sapiens_hsa002400.87973293
54Viral myocarditis_Homo sapiens_hsa054160.83259958
55RNA polymerase_Homo sapiens_hsa030200.83126885
56Phenylalanine metabolism_Homo sapiens_hsa003600.82913769
57Cell cycle_Homo sapiens_hsa041100.82799310
58Glutathione metabolism_Homo sapiens_hsa004800.82588674
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.78245189
60Pentose phosphate pathway_Homo sapiens_hsa000300.75553909
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74549110
62Histidine metabolism_Homo sapiens_hsa003400.73263511
63Proteasome_Homo sapiens_hsa030500.71314175
64Fructose and mannose metabolism_Homo sapiens_hsa000510.70778930
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70680464
66One carbon pool by folate_Homo sapiens_hsa006700.70148958
67N-Glycan biosynthesis_Homo sapiens_hsa005100.70115086
68Galactose metabolism_Homo sapiens_hsa000520.69423095
69Lysine degradation_Homo sapiens_hsa003100.69309548
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68771748
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67165265
72RNA transport_Homo sapiens_hsa030130.64865149
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.64860259
74Non-homologous end-joining_Homo sapiens_hsa034500.61934085
75Tyrosine metabolism_Homo sapiens_hsa003500.61746902
76Fat digestion and absorption_Homo sapiens_hsa049750.61349395
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60918837
78Base excision repair_Homo sapiens_hsa034100.59124996
79Chemical carcinogenesis_Homo sapiens_hsa052040.57964745
80Steroid biosynthesis_Homo sapiens_hsa001000.56657446
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52609667
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51792702
83Caffeine metabolism_Homo sapiens_hsa002320.51010406
84Arachidonic acid metabolism_Homo sapiens_hsa005900.49953617
85Homologous recombination_Homo sapiens_hsa034400.47800827
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46763151
87Nucleotide excision repair_Homo sapiens_hsa034200.46437294
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45948130
89Retinol metabolism_Homo sapiens_hsa008300.44677314
90Systemic lupus erythematosus_Homo sapiens_hsa053220.43741938
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.43067455
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42653539
93Linoleic acid metabolism_Homo sapiens_hsa005910.38850395
94Purine metabolism_Homo sapiens_hsa002300.38518910
95Bladder cancer_Homo sapiens_hsa052190.38274790
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.37871317
97Primary immunodeficiency_Homo sapiens_hsa053400.36961407
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36103900
99ABC transporters_Homo sapiens_hsa020100.35011126
100Vitamin digestion and absorption_Homo sapiens_hsa049770.32023181
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30988475
102Complement and coagulation cascades_Homo sapiens_hsa046100.28564577
103Glycerolipid metabolism_Homo sapiens_hsa005610.27845397
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.26077817
105Epstein-Barr virus infection_Homo sapiens_hsa051690.25951447
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.25753051
107Fatty acid biosynthesis_Homo sapiens_hsa000610.22817803
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19970863
109Other glycan degradation_Homo sapiens_hsa005110.19840209
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.19826249
111Insulin signaling pathway_Homo sapiens_hsa049100.19641849
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19286661
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18944917
114AMPK signaling pathway_Homo sapiens_hsa041520.17908602
115Alcoholism_Homo sapiens_hsa050340.17619178
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17608386
117Glucagon signaling pathway_Homo sapiens_hsa049220.16844901
118p53 signaling pathway_Homo sapiens_hsa041150.15278684
119Vibrio cholerae infection_Homo sapiens_hsa051100.13450441
120Acute myeloid leukemia_Homo sapiens_hsa052210.12097653
121Pancreatic cancer_Homo sapiens_hsa052120.12011004
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.11577255
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10959555
124Chronic myeloid leukemia_Homo sapiens_hsa052200.10907399
125Bile secretion_Homo sapiens_hsa049760.10540642
126Viral carcinogenesis_Homo sapiens_hsa052030.09668707
127mRNA surveillance pathway_Homo sapiens_hsa030150.08750923
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.08147844

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