NUF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.09004936
2kinetochore organization (GO:0051383)5.76168028
3attachment of spindle microtubules to kinetochore (GO:0008608)5.61158794
4mitotic chromosome condensation (GO:0007076)5.49118676
5protein localization to chromosome, centromeric region (GO:0071459)5.45184058
6mitotic metaphase plate congression (GO:0007080)5.44532158
7mitotic sister chromatid segregation (GO:0000070)5.44140117
8CENP-A containing nucleosome assembly (GO:0034080)5.34150282
9chromatin remodeling at centromere (GO:0031055)5.21766043
10sister chromatid segregation (GO:0000819)5.21420427
11metaphase plate congression (GO:0051310)5.01150852
12meiotic chromosome segregation (GO:0045132)4.97496720
13kinetochore assembly (GO:0051382)4.80556385
14regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.79078722
15DNA replication-independent nucleosome assembly (GO:0006336)4.76846350
16DNA replication-independent nucleosome organization (GO:0034724)4.76846350
17establishment of chromosome localization (GO:0051303)4.76407469
18DNA unwinding involved in DNA replication (GO:0006268)4.69164275
19DNA strand elongation involved in DNA replication (GO:0006271)4.68530393
20telomere maintenance via semi-conservative replication (GO:0032201)4.60704126
21regulation of spindle organization (GO:0090224)4.53219050
22histone exchange (GO:0043486)4.50617340
23DNA strand elongation (GO:0022616)4.45359435
24DNA replication initiation (GO:0006270)4.43014558
25mitotic recombination (GO:0006312)4.40161749
26telomere maintenance via recombination (GO:0000722)4.38053414
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.19016917
28DNA replication checkpoint (GO:0000076)4.16835725
29mitotic nuclear envelope disassembly (GO:0007077)4.07940626
30mitotic sister chromatid cohesion (GO:0007064)4.06825939
31DNA replication-dependent nucleosome assembly (GO:0006335)4.06482838
32DNA replication-dependent nucleosome organization (GO:0034723)4.06482838
33spindle checkpoint (GO:0031577)4.05733588
34protein localization to chromosome (GO:0034502)4.00259153
35establishment of integrated proviral latency (GO:0075713)3.98811891
36regulation of chromosome segregation (GO:0051983)3.96253737
37* chromosome segregation (GO:0007059)3.93127755
38regulation of mitotic spindle organization (GO:0060236)3.90723954
39positive regulation of chromosome segregation (GO:0051984)3.80615357
40nucleotide-excision repair, DNA gap filling (GO:0006297)3.79466708
41telomere maintenance via telomere lengthening (GO:0010833)3.78424136
42nuclear pore organization (GO:0006999)3.77926422
43spindle assembly checkpoint (GO:0071173)3.77593982
44chromatin assembly or disassembly (GO:0006333)3.76335165
45nuclear envelope disassembly (GO:0051081)3.76197495
46membrane disassembly (GO:0030397)3.76197495
47regulation of centrosome cycle (GO:0046605)3.74601930
48chromosome condensation (GO:0030261)3.74282998
49DNA topological change (GO:0006265)3.72828502
50regulation of mitotic metaphase/anaphase transition (GO:0030071)3.71850511
51negative regulation of chromosome segregation (GO:0051985)3.70882974
52negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.69667984
53negative regulation of sister chromatid segregation (GO:0033046)3.69667984
54negative regulation of mitotic sister chromatid separation (GO:2000816)3.69667984
55negative regulation of mitotic sister chromatid segregation (GO:0033048)3.69667984
56regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.68434370
57nuclear pore complex assembly (GO:0051292)3.67754467
58positive regulation of mitotic sister chromatid separation (GO:1901970)3.66395271
59positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.66395271
60positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.66395271
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.65311287
62regulation of sister chromatid cohesion (GO:0007063)3.59997753
63mitotic spindle assembly checkpoint (GO:0007094)3.59804941
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.58396335
65mitotic spindle checkpoint (GO:0071174)3.56825419
66microtubule depolymerization (GO:0007019)3.56705617
67regulation of sister chromatid segregation (GO:0033045)3.54720754
68regulation of mitotic sister chromatid separation (GO:0010965)3.54720754
69regulation of mitotic sister chromatid segregation (GO:0033047)3.54720754
70centriole replication (GO:0007099)3.48212315
71ATP-dependent chromatin remodeling (GO:0043044)3.44760965
72regulation of centriole replication (GO:0046599)3.44345095
73DNA packaging (GO:0006323)3.39983525
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.37965759
75microtubule polymerization or depolymerization (GO:0031109)3.37391736
76protein K6-linked ubiquitination (GO:0085020)3.35140291
77DNA ligation (GO:0006266)3.30814580
78regulation of double-strand break repair via homologous recombination (GO:0010569)3.30250002
79mitotic spindle organization (GO:0007052)3.29212199
80histone-serine phosphorylation (GO:0035404)3.29185052
81mitotic G2 DNA damage checkpoint (GO:0007095)3.26977013
82DNA geometric change (GO:0032392)3.21934320
83DNA duplex unwinding (GO:0032508)3.21224494
84DNA conformation change (GO:0071103)3.19378136
85* mitotic cell cycle (GO:0000278)3.18973656
86ventricular cardiac muscle cell development (GO:0055015)3.17548498
87mismatch repair (GO:0006298)3.17001866
88negative regulation of cell division (GO:0051782)3.14790412
89spindle assembly involved in mitosis (GO:0090307)3.14291782
90DNA double-strand break processing (GO:0000729)3.13870863
91resolution of meiotic recombination intermediates (GO:0000712)3.12245436
92establishment of mitotic spindle localization (GO:0040001)3.12013202
93telomere maintenance (GO:0000723)3.11505427
94negative regulation of nuclear division (GO:0051784)3.10912873
95non-recombinational repair (GO:0000726)3.10397433
96double-strand break repair via nonhomologous end joining (GO:0006303)3.10397433
97telomere organization (GO:0032200)3.08086587
98regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.07739923
99negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.07336179
100DNA synthesis involved in DNA repair (GO:0000731)3.04741555
101regulation of centrosome duplication (GO:0010824)3.03630444
102replication fork processing (GO:0031297)3.01338601
103translesion synthesis (GO:0019985)3.00743919
104chromosome organization (GO:0051276)3.00650447
105maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99402030
106regulation of DNA endoreduplication (GO:0032875)2.98582678
107nuclear envelope organization (GO:0006998)2.96240646
108regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.96012026
109regulation of mitotic spindle checkpoint (GO:1903504)2.96012026
110negative regulation of mitosis (GO:0045839)2.95104419
111ribosomal small subunit assembly (GO:0000028)2.91594629
112regulation of histone H3-K9 methylation (GO:0051570)2.90148990
113regulation of spindle checkpoint (GO:0090231)2.88130637
114mitotic G2/M transition checkpoint (GO:0044818)2.87039734
115* mitotic nuclear division (GO:0007067)2.86053382
116regulation of exit from mitosis (GO:0007096)2.84596128
117pore complex assembly (GO:0046931)2.84418270
118negative regulation of DNA-dependent DNA replication (GO:2000104)2.81275074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human7.10910380
2E2F4_17652178_ChIP-ChIP_JURKAT_Human5.17942619
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.66243339
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.56333390
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.13516364
6AR_21909140_ChIP-Seq_LNCAP_Human3.05763624
7* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94834508
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.84427535
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.52237993
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.51162214
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45114967
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41755873
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30290530
14* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.26895530
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.26210556
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.22918105
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21909800
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13403333
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.12231949
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.05064134
21* ETS1_20019798_ChIP-Seq_JURKAT_Human2.02637784
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.01527799
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01076429
24E2F7_22180533_ChIP-Seq_HELA_Human10.9373040
25* XRN2_22483619_ChIP-Seq_HELA_Human1.98243618
26* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94519173
27* VDR_23849224_ChIP-Seq_CD4+_Human1.94115715
28* FOXP3_21729870_ChIP-Seq_TREG_Human1.81285916
29ELK1_19687146_ChIP-ChIP_HELA_Human1.78341451
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76900320
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76521715
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71456627
33* DCP1A_22483619_ChIP-Seq_HELA_Human1.69267467
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66504353
35* TTF2_22483619_ChIP-Seq_HELA_Human1.63175162
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61917598
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59149541
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51652746
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51159020
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49470077
41CIITA_25753668_ChIP-Seq_RAJI_Human1.48535040
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47934311
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45938567
44* GABP_19822575_ChIP-Seq_HepG2_Human1.45868762
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44992782
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44761136
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40865652
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.37327512
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31683929
50* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29388564
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29084107
52KDM5A_27292631_Chip-Seq_BREAST_Human1.28136055
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27654371
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26480569
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23303992
56* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22573162
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20976061
58MYC_22102868_ChIP-Seq_BL_Human1.19132751
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.18551759
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14182347
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11666408
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11507977
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11220991
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08083040
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08068131
66MYC_18940864_ChIP-ChIP_HL60_Human1.07922196
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.02359893
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01382061
69EWS_26573619_Chip-Seq_HEK293_Human1.00472976
70CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99099548
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97606240
72NANOG_16153702_ChIP-ChIP_HESCs_Human0.96406304
73* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91895500
74SPI1_23547873_ChIP-Seq_NB4_Human0.89298029
75* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88858526
76TFEB_21752829_ChIP-Seq_HELA_Human0.88391167
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.87704596
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87145546
79* YY1_21170310_ChIP-Seq_MESCs_Mouse0.86938855
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86487090
81POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85864588
82VDR_21846776_ChIP-Seq_THP-1_Human0.83859150
83* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83589599
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82524975
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82369203
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80647950
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78963373
88NANOG_21062744_ChIP-ChIP_HESCs_Human0.78251786
89SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77616076
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75416054
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.72804577
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71878474
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.70959422
94FUS_26573619_Chip-Seq_HEK293_Human0.70457542
95* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69550782
96TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.69488690
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.69056063
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.68366338
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.67710472
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.66548032
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.64869153
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.64744375
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.64213938
104MYB_26560356_Chip-Seq_TH2_Human0.64059711
105SOX2_16153702_ChIP-ChIP_HESCs_Human0.63504219
106CHD1_26751641_Chip-Seq_LNCaP_Human0.62786598
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.62525416
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.61667712
109MYB_21317192_ChIP-Seq_ERMYB_Mouse0.61016217
110WT1_19549856_ChIP-ChIP_CCG9911_Human0.59513593
111IRF1_19129219_ChIP-ChIP_H3396_Human0.56796544
112NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.56062894

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.59400497
2MP0010094_abnormal_chromosome_stability5.31284755
3MP0003111_abnormal_nucleus_morphology4.74227535
4MP0003077_abnormal_cell_cycle4.22269480
5MP0004957_abnormal_blastocyst_morpholog4.02813163
6MP0008057_abnormal_DNA_replication3.84575752
7MP0008058_abnormal_DNA_repair3.21612412
8MP0008007_abnormal_cellular_replicative2.91974425
9MP0008932_abnormal_embryonic_tissue2.74446551
10MP0008877_abnormal_DNA_methylation2.70336792
11MP0002396_abnormal_hematopoietic_system2.42633799
12MP0000350_abnormal_cell_proliferation2.14088347
13MP0003123_paternal_imprinting2.07610043
14MP0010307_abnormal_tumor_latency2.06103871
15MP0001730_embryonic_growth_arrest1.99211871
16MP0003786_premature_aging1.73779488
17MP0004808_abnormal_hematopoietic_stem1.69632846
18MP0003718_maternal_effect1.68983722
19MP0000490_abnormal_crypts_of1.68712652
20MP0003121_genomic_imprinting1.60971560
21MP0001697_abnormal_embryo_size1.59879603
22MP0003136_yellow_coat_color1.59836220
23MP0001672_abnormal_embryogenesis/_devel1.58878307
24MP0005380_embryogenesis_phenotype1.58878307
25MP0002210_abnormal_sex_determination1.54504885
26MP0002085_abnormal_embryonic_tissue1.45685028
27MP0002019_abnormal_tumor_incidence1.44923085
28MP0002102_abnormal_ear_morphology1.43599300
29MP0001929_abnormal_gametogenesis1.43268387
30MP0000566_synostosis1.39533838
31MP0000313_abnormal_cell_death1.38109729
32MP0002080_prenatal_lethality1.37242909
33MP0003984_embryonic_growth_retardation1.37191759
34MP0010352_gastrointestinal_tract_polyps1.36191097
35MP0002697_abnormal_eye_size1.34032475
36MP0002088_abnormal_embryonic_growth/wei1.32918862
37MP0002084_abnormal_developmental_patter1.27966194
38MP0001145_abnormal_male_reproductive1.27691123
39MP0005076_abnormal_cell_differentiation1.20965486
40MP0000653_abnormal_sex_gland1.20780612
41MP0002086_abnormal_extraembryonic_tissu1.20369663
42MP0006054_spinal_hemorrhage1.19796583
43MP0009379_abnormal_foot_pigmentation1.19316992
44MP0008789_abnormal_olfactory_epithelium1.18560382
45MP0002234_abnormal_pharynx_morphology1.18322210
46MP0010030_abnormal_orbit_morphology1.17345256
47MP0001346_abnormal_lacrimal_gland1.16137649
48MP0001119_abnormal_female_reproductive1.13401556
49MP0004197_abnormal_fetal_growth/weight/1.12904703
50MP0000703_abnormal_thymus_morphology1.12355380
51MP0003937_abnormal_limbs/digits/tail_de1.10106147
52MP0001529_abnormal_vocalization1.09881033
53MP0003315_abnormal_perineum_morphology1.08776666
54MP0003890_abnormal_embryonic-extraembry1.07917878
55MP0003567_abnormal_fetal_cardiomyocyte1.07641594
56MP0003763_abnormal_thymus_physiology1.07482820
57MP0002398_abnormal_bone_marrow1.06888012
58MP0005397_hematopoietic_system_phenotyp1.05731422
59MP0001545_abnormal_hematopoietic_system1.05731422
60MP0006292_abnormal_olfactory_placode1.04224903
61MP0002233_abnormal_nose_morphology1.03324074
62MP0000372_irregular_coat_pigmentation0.99631914
63MP0000049_abnormal_middle_ear0.96560316
64MP0001293_anophthalmia0.95090209
65MP0002722_abnormal_immune_system0.93374035
66MP0006072_abnormal_retinal_apoptosis0.92801965
67MP0000358_abnormal_cell_content/0.91736821
68MP0000689_abnormal_spleen_morphology0.90406798
69MP0006035_abnormal_mitochondrial_morpho0.89556213
70MP0005171_absent_coat_pigmentation0.88636803
71MP0003119_abnormal_digestive_system0.87717577
72MP0002095_abnormal_skin_pigmentation0.85657637
73MP0003861_abnormal_nervous_system0.84859678
74MP0005394_taste/olfaction_phenotype0.84053262
75MP0005499_abnormal_olfactory_system0.84053262
76MP0003787_abnormal_imprinting0.82650024
77MP0009333_abnormal_splenocyte_physiolog0.82456917
78MP0000858_altered_metastatic_potential0.81976022
79MP0003698_abnormal_male_reproductive0.79202372
80MP0003385_abnormal_body_wall0.79200970
81MP0002877_abnormal_melanocyte_morpholog0.77112839
82MP0002429_abnormal_blood_cell0.76605964
83MP0009278_abnormal_bone_marrow0.76476027
84MP0001915_intracranial_hemorrhage0.76297102
85MP0002160_abnormal_reproductive_system0.75443215
86MP0000647_abnormal_sebaceous_gland0.74095656
87MP0005389_reproductive_system_phenotype0.74089825
88MP0005391_vision/eye_phenotype0.73320161
89MP0000569_abnormal_digit_pigmentation0.71529310
90MP0003699_abnormal_female_reproductive0.71287031
91MP0009703_decreased_birth_body0.70881883
92MP0009053_abnormal_anal_canal0.70480247
93MP0002111_abnormal_tail_morphology0.69857795
94MP0009672_abnormal_birth_weight0.69833361
95MP0005395_other_phenotype0.68987878
96MP0005621_abnormal_cell_physiology0.68757422
97MP0009697_abnormal_copulation0.68721817
98MP0005384_cellular_phenotype0.68335962
99MP0002161_abnormal_fertility/fecundity0.67547718
100MP0000015_abnormal_ear_pigmentation0.66692184
101MP0003941_abnormal_skin_development0.66677006
102MP0003806_abnormal_nucleotide_metabolis0.66577638
103MP0003656_abnormal_erythrocyte_physiolo0.66450441
104MP0002009_preneoplasia0.65548639
105MP0000432_abnormal_head_morphology0.65460578
106MP0000716_abnormal_immune_system0.65420348
107MP0005023_abnormal_wound_healing0.65081000
108MP0008995_early_reproductive_senescence0.63985414
109MP0002751_abnormal_autonomic_nervous0.63305771
110MP0005174_abnormal_tail_pigmentation0.62990827
111MP0004147_increased_porphyrin_level0.62843186
112MP0001919_abnormal_reproductive_system0.62682637
113MP0003186_abnormal_redox_activity0.62188631
114MP0002938_white_spotting0.62182743
115MP0000428_abnormal_craniofacial_morphol0.61692657
116MP0009250_abnormal_appendicular_skeleto0.61405635
117MP0005408_hypopigmentation0.60170117
118MP0003566_abnormal_cell_adhesion0.60123808
119MP0001286_abnormal_eye_development0.59597643
120MP0000762_abnormal_tongue_morphology0.59229142
121MP0003705_abnormal_hypodermis_morpholog0.59086350
122MP0000631_abnormal_neuroendocrine_gland0.57885073
123MP0002282_abnormal_trachea_morphology0.56564629
124MP0002932_abnormal_joint_morphology0.56287281
125MP0003755_abnormal_palate_morphology0.56200739
126MP0000537_abnormal_urethra_morphology0.54527019
127MP0002092_abnormal_eye_morphology0.54436161
128MP0001800_abnormal_humoral_immune0.54104841
129MP0002420_abnormal_adaptive_immunity0.54053043
130MP0003935_abnormal_craniofacial_develop0.53984562
131MP0003950_abnormal_plasma_membrane0.53372145
132MP0000383_abnormal_hair_follicle0.52618221

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.92667592
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.73252960
3Abnormality of chromosome stability (HP:0003220)4.12013816
4Birth length less than 3rd percentile (HP:0003561)4.07698229
5Cortical dysplasia (HP:0002539)3.93771408
6Meckel diverticulum (HP:0002245)3.86371367
7Reticulocytopenia (HP:0001896)3.81684684
8Abnormality of the preputium (HP:0100587)3.80646502
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.67374109
10Abnormality of the ileum (HP:0001549)3.65848901
11Duodenal stenosis (HP:0100867)3.51030647
12Small intestinal stenosis (HP:0012848)3.51030647
13Volvulus (HP:0002580)3.30408571
14Patellar aplasia (HP:0006443)3.25895426
15Breast hypoplasia (HP:0003187)3.22198181
16Myelodysplasia (HP:0002863)3.18335081
17Ectopic kidney (HP:0000086)3.16116642
18Aplasia/Hypoplasia of the patella (HP:0006498)3.01755123
19Selective tooth agenesis (HP:0001592)3.00393339
20Abnormal lung lobation (HP:0002101)2.98596043
21Increased nuchal translucency (HP:0010880)2.98363105
22Impulsivity (HP:0100710)2.96257809
23Sloping forehead (HP:0000340)2.90033897
24Duplicated collecting system (HP:0000081)2.88208712
25Nephroblastoma (Wilms tumor) (HP:0002667)2.83321862
26Abnormality of the duodenum (HP:0002246)2.80306673
27Colon cancer (HP:0003003)2.74449896
28Abnormality of the carotid arteries (HP:0005344)2.73838824
29Medulloblastoma (HP:0002885)2.67673143
30Abnormality of the renal collecting system (HP:0004742)2.67110910
31Embryonal renal neoplasm (HP:0011794)2.64355119
32Bone marrow hypocellularity (HP:0005528)2.59008747
33Absent radius (HP:0003974)2.58267361
34Clubbing of toes (HP:0100760)2.56738917
3511 pairs of ribs (HP:0000878)2.53951066
36Oral leukoplakia (HP:0002745)2.50220506
37Absent forearm bone (HP:0003953)2.45211279
38Aplasia involving forearm bones (HP:0009822)2.45211279
39Degeneration of anterior horn cells (HP:0002398)2.44387551
40Abnormality of the anterior horn cell (HP:0006802)2.44387551
41Absent thumb (HP:0009777)2.43643558
42Short 4th metacarpal (HP:0010044)2.40553396
43Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.40553396
44Short thumb (HP:0009778)2.33400005
45Carpal bone hypoplasia (HP:0001498)2.33395485
46Aplastic anemia (HP:0001915)2.32872083
47Supernumerary spleens (HP:0009799)2.29274843
48Hypoplasia of the capital femoral epiphysis (HP:0003090)2.28280944
49High pitched voice (HP:0001620)2.27620206
50Abnormality of DNA repair (HP:0003254)2.25680573
51Triphalangeal thumb (HP:0001199)2.25605163
52Embryonal neoplasm (HP:0002898)2.23757895
53Agnosia (HP:0010524)2.23492685
54Hypoplastic pelvis (HP:0008839)2.21451379
55Tracheoesophageal fistula (HP:0002575)2.18902784
56Abnormality of cells of the erythroid lineage (HP:0012130)2.16459711
57Rhabdomyosarcoma (HP:0002859)2.16000633
58Aplasia/Hypoplasia of the sternum (HP:0006714)2.14930568
59Septo-optic dysplasia (HP:0100842)2.14443223
60Abnormal number of erythroid precursors (HP:0012131)2.14096776
61Proximal placement of thumb (HP:0009623)2.13954518
62Cafe-au-lait spot (HP:0000957)2.13464916
63Deviation of the thumb (HP:0009603)2.12728021
64Facial hemangioma (HP:0000329)2.08831601
65Horseshoe kidney (HP:0000085)2.07920423
66Atresia of the external auditory canal (HP:0000413)2.07843146
67Abnormality of the labia minora (HP:0012880)2.06115719
68Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02217680
69Absent septum pellucidum (HP:0001331)2.01671756
70Duplication of thumb phalanx (HP:0009942)2.01278623
71Single umbilical artery (HP:0001195)2.01194067
72Abnormality of the fetal cardiovascular system (HP:0010948)2.01194067
73Abnormal umbilical cord blood vessels (HP:0011403)2.01194067
74Abnormal number of incisors (HP:0011064)2.01162650
75Overlapping toe (HP:0001845)2.00076441
76Thrombocytosis (HP:0001894)1.93743924
77Short middle phalanx of the 5th finger (HP:0004220)1.92383847
78Abnormality of the septum pellucidum (HP:0007375)1.92026750
79Premature graying of hair (HP:0002216)1.91803512
80Neoplasm of the pancreas (HP:0002894)1.90992283
81Squamous cell carcinoma (HP:0002860)1.87467684
82Macrocytic anemia (HP:0001972)1.85441755
83Abnormality of cochlea (HP:0000375)1.84790943
84Neoplasm of the colon (HP:0100273)1.84563235
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83758539
86Arteriovenous malformation (HP:0100026)1.82750379
87Prominent nose (HP:0000448)1.82725228
88Pallor (HP:0000980)1.81694860
89Acute myeloid leukemia (HP:0004808)1.80399453
90Oligodactyly (hands) (HP:0001180)1.79887554
91Abnormality of abdominal situs (HP:0011620)1.78899161
92Abdominal situs inversus (HP:0003363)1.78899161
93Abnormality of chromosome segregation (HP:0002916)1.77585256
94Deep philtrum (HP:0002002)1.75625885
95Slender long bone (HP:0003100)1.74023058
96Aplasia/Hypoplasia of the earlobes (HP:0009906)1.73855344
97Rough bone trabeculation (HP:0100670)1.73677127
98Increased serum pyruvate (HP:0003542)1.72099407
99Hypoplasia of the pons (HP:0012110)1.71598486
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.71463696
101Microvesicular hepatic steatosis (HP:0001414)1.70991008
102Abnormality of the calcaneus (HP:0008364)1.70186605
103Basal cell carcinoma (HP:0002671)1.69429956
104Abnormality of the umbilical cord (HP:0010881)1.68268348
105Abnormality of the fingertips (HP:0001211)1.67832132
106Microtia (HP:0008551)1.67774942
107Cellular immunodeficiency (HP:0005374)1.66895899
108Abnormal spermatogenesis (HP:0008669)1.66860387
109Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.66369723
110Absent epiphyses (HP:0010577)1.66369723
111Abnormality of glycolysis (HP:0004366)1.66311457
112Ependymoma (HP:0002888)1.65812486
113Abnormal auditory evoked potentials (HP:0006958)1.65085398
114Holoprosencephaly (HP:0001360)1.64743364
115Ovarian neoplasm (HP:0100615)1.64660541
116Choanal atresia (HP:0000453)1.64457848
117Morphological abnormality of the inner ear (HP:0011390)1.64423217
118Intestinal atresia (HP:0011100)1.64045568
119Cleft eyelid (HP:0000625)1.63976936
120Small hand (HP:0200055)1.63743490
121Irregular epiphyses (HP:0010582)1.63538550
122Increased hepatocellular lipid droplets (HP:0006565)1.63273100
123Oligodactyly (HP:0012165)1.62829683
124Acute necrotizing encephalopathy (HP:0006965)1.62506835
125Microretrognathia (HP:0000308)1.62371224
126Missing ribs (HP:0000921)1.61560239
127Abnormality of the pons (HP:0007361)1.61019511
128Multiple enchondromatosis (HP:0005701)1.60858767
129Blepharitis (HP:0000498)1.59920137
130Hemivertebrae (HP:0002937)1.59290518
131Acute encephalopathy (HP:0006846)1.58860071
132Facial cleft (HP:0002006)1.55538486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.03868931
2BUB14.88779970
3WEE13.94971460
4NEK23.59121875
5TTK3.14849110
6BRSK22.84371628
7PLK42.80751620
8EIF2AK12.72081575
9SRPK12.46244099
10PLK12.37254294
11NEK12.29964012
12CCNB12.27643806
13VRK22.23331840
14AURKB2.21306708
15VRK11.96850990
16ACVR1B1.93468585
17STK101.84315714
18BRSK11.83525283
19MKNK11.81618390
20PLK31.79493762
21ATR1.79102091
22STK41.77094218
23CHEK21.74774484
24TLK11.59612243
25EEF2K1.59087293
26MAP3K81.58490047
27RPS6KA41.56177103
28TESK21.51051965
29CDK71.49535551
30CDK41.46337142
31ZAK1.36481531
32PNCK1.35562969
33PASK1.31318095
34AURKA1.30777570
35DYRK31.26566314
36CHEK11.25084058
37CDK121.25008275
38MKNK21.23779986
39MELK1.20210613
40TAF11.18514047
41RPS6KB21.16794026
42PBK1.09445182
43EIF2AK31.08847897
44STK161.08202804
45CDK61.05307177
46STK31.05301183
47MST41.05288477
48ATM1.02803206
49TRIM281.00866902
50EIF2AK20.92029438
51TSSK60.87418122
52NME20.85031474
53CLK10.83929521
54CDK20.81481192
55TGFBR10.81402061
56BRAF0.80902672
57LATS10.79886669
58PIM10.76648628
59CDK10.76118169
60TESK10.74490513
61BRD40.73885609
62CDK80.72702957
63NME10.66652289
64PAK40.64754392
65NUAK10.60385348
66MAP4K10.58529541
67CDK90.57194444
68CDK30.56758732
69MAP3K100.56389624
70PAK10.56072835
71RPS6KA50.55871907
72LATS20.54832444
73CSNK2A10.53899943
74SCYL20.52888308
75TRPM70.51807001
76NEK90.51032017
77UHMK10.50203154
78PLK20.49390058
79BCR0.49388607
80LRRK20.45242616
81CSNK2A20.43325678
82MET0.42879631
83CDK140.42846517
84TNIK0.42146769
85TEC0.40810786
86WNK30.39970706
87FGFR10.39164547
88IRAK40.38460419
89BMPR1B0.37852835
90ERBB40.37357824
91FLT30.36734467
92ALK0.35681224
93YES10.34345007
94BTK0.32943337
95DMPK0.32941137
96RAF10.32912662
97PRKDC0.31723123
98CSNK1E0.30830246
99MAP3K60.29419554
100STK38L0.28339298
101MARK30.28096461
102MAPK140.27125781
103MST1R0.26960562
104KSR10.26192543
105TXK0.24096112
106AKT10.23474772
107CDK11A0.23070010
108PDK20.22776432
109ILK0.22064298
110PKN20.21983627
111CDK150.21308773
112MINK10.20341458
113ERBB30.20123706
114CDK180.20013862
115AKT20.19158029
116PDK40.18988229
117PDK30.18988229
118MOS0.18547714
119PRKCI0.17695097
120SMG10.17661581
121LYN0.17298556
122MAPKAPK20.17222184
123BLK0.16368709
124JAK30.15029206
125MAPK10.14970221
126CSF1R0.14537612
127CSNK1D0.14295801
128GSK3B0.13707360

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.27933826
2Mismatch repair_Homo sapiens_hsa034304.57255893
3Cell cycle_Homo sapiens_hsa041103.55460968
4Homologous recombination_Homo sapiens_hsa034403.50008547
5Base excision repair_Homo sapiens_hsa034103.31250364
6Fanconi anemia pathway_Homo sapiens_hsa034603.12646721
7Spliceosome_Homo sapiens_hsa030403.06846622
8Nucleotide excision repair_Homo sapiens_hsa034203.04530230
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93750887
10RNA transport_Homo sapiens_hsa030132.86963416
11Non-homologous end-joining_Homo sapiens_hsa034502.67295436
12One carbon pool by folate_Homo sapiens_hsa006702.35843133
13Ribosome_Homo sapiens_hsa030102.31550816
14RNA polymerase_Homo sapiens_hsa030202.23722883
15RNA degradation_Homo sapiens_hsa030182.21128851
16Proteasome_Homo sapiens_hsa030502.14047167
17Pyrimidine metabolism_Homo sapiens_hsa002402.12289059
18Basal transcription factors_Homo sapiens_hsa030222.02764609
19p53 signaling pathway_Homo sapiens_hsa041151.91485455
20Systemic lupus erythematosus_Homo sapiens_hsa053221.90529001
21mRNA surveillance pathway_Homo sapiens_hsa030151.80285790
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73954939
23Oocyte meiosis_Homo sapiens_hsa041141.39536487
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27035750
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23921710
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23801863
27Viral carcinogenesis_Homo sapiens_hsa052031.21249876
28Pyruvate metabolism_Homo sapiens_hsa006201.15560168
29Purine metabolism_Homo sapiens_hsa002301.14362092
30Parkinsons disease_Homo sapiens_hsa050121.13989933
31Epstein-Barr virus infection_Homo sapiens_hsa051691.13879293
32Herpes simplex infection_Homo sapiens_hsa051681.06610239
33Oxidative phosphorylation_Homo sapiens_hsa001901.06445166
34Steroid biosynthesis_Homo sapiens_hsa001001.04786215
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01073225
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00624431
37MicroRNAs in cancer_Homo sapiens_hsa052060.99186715
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97040035
39HTLV-I infection_Homo sapiens_hsa051660.95809565
40Small cell lung cancer_Homo sapiens_hsa052220.89930069
41Antigen processing and presentation_Homo sapiens_hsa046120.89860745
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83911313
43Vitamin B6 metabolism_Homo sapiens_hsa007500.82116659
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81803978
45Carbon metabolism_Homo sapiens_hsa012000.80832713
46Alcoholism_Homo sapiens_hsa050340.79566410
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78793923
48Propanoate metabolism_Homo sapiens_hsa006400.78482443
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76698127
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73503089
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72661991
52Fatty acid elongation_Homo sapiens_hsa000620.70207246
53Primary immunodeficiency_Homo sapiens_hsa053400.63457872
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60819472
55TGF-beta signaling pathway_Homo sapiens_hsa043500.59659380
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58410991
57Apoptosis_Homo sapiens_hsa042100.57445917
58Protein export_Homo sapiens_hsa030600.56978165
59Alzheimers disease_Homo sapiens_hsa050100.56583697
60Hepatitis B_Homo sapiens_hsa051610.55687639
61Colorectal cancer_Homo sapiens_hsa052100.55242798
62Measles_Homo sapiens_hsa051620.52899942
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51623900
64Pentose phosphate pathway_Homo sapiens_hsa000300.49878084
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.49157249
66Pancreatic cancer_Homo sapiens_hsa052120.48810336
67Chronic myeloid leukemia_Homo sapiens_hsa052200.48678807
68Thyroid cancer_Homo sapiens_hsa052160.48068597
69Legionellosis_Homo sapiens_hsa051340.46834203
70Shigellosis_Homo sapiens_hsa051310.46352033
71Viral myocarditis_Homo sapiens_hsa054160.45422566
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43992294
73Hematopoietic cell lineage_Homo sapiens_hsa046400.43465773
74Hippo signaling pathway_Homo sapiens_hsa043900.43387198
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42076016
76Basal cell carcinoma_Homo sapiens_hsa052170.42055319
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41741962
78Selenocompound metabolism_Homo sapiens_hsa004500.40291044
79Glutathione metabolism_Homo sapiens_hsa004800.38966619
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.36768938
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36218797
82Metabolic pathways_Homo sapiens_hsa011000.35529462
83Pathways in cancer_Homo sapiens_hsa052000.34996912
84Influenza A_Homo sapiens_hsa051640.34992979
85Adherens junction_Homo sapiens_hsa045200.33712443
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33647806
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.32635640
88Notch signaling pathway_Homo sapiens_hsa043300.30557726
89Sulfur relay system_Homo sapiens_hsa041220.30099109
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29864111
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29731318
92N-Glycan biosynthesis_Homo sapiens_hsa005100.29478362
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29432035
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28689820
95Leishmaniasis_Homo sapiens_hsa051400.28526048
96Prostate cancer_Homo sapiens_hsa052150.28038236
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27778973
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26198509
99Bladder cancer_Homo sapiens_hsa052190.24779542
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24209764
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23984159
102FoxO signaling pathway_Homo sapiens_hsa040680.23547398
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.23339663
104B cell receptor signaling pathway_Homo sapiens_hsa046620.23126714
105Allograft rejection_Homo sapiens_hsa053300.22960633
106Huntingtons disease_Homo sapiens_hsa050160.22907976
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.22478241
108Fatty acid metabolism_Homo sapiens_hsa012120.22361637
109Non-small cell lung cancer_Homo sapiens_hsa052230.22126872
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.21881269
111Autoimmune thyroid disease_Homo sapiens_hsa053200.21525435
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21244227
113Melanoma_Homo sapiens_hsa052180.19770887
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19293810
115Arachidonic acid metabolism_Homo sapiens_hsa005900.18856465
116Lysine degradation_Homo sapiens_hsa003100.18520588
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18473978
118Biosynthesis of amino acids_Homo sapiens_hsa012300.17991627
119Folate biosynthesis_Homo sapiens_hsa007900.17868130
120Asthma_Homo sapiens_hsa053100.17652447
121Hedgehog signaling pathway_Homo sapiens_hsa043400.17287321
122Toxoplasmosis_Homo sapiens_hsa051450.14667767
123Arginine and proline metabolism_Homo sapiens_hsa003300.14101786
124Wnt signaling pathway_Homo sapiens_hsa043100.13923139
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.13793954
126HIF-1 signaling pathway_Homo sapiens_hsa040660.13622655
127Renin-angiotensin system_Homo sapiens_hsa046140.13201130
128Graft-versus-host disease_Homo sapiens_hsa053320.12924294
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.07987402
130Cardiac muscle contraction_Homo sapiens_hsa042600.06782727
131Gap junction_Homo sapiens_hsa045400.04284190
132Olfactory transduction_Homo sapiens_hsa047400.02357883
133Butanoate metabolism_Homo sapiens_hsa006500.01034792

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