NUFIP1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)5.34791505
2ATP synthesis coupled proton transport (GO:0015986)5.34791505
3tachykinin receptor signaling pathway (GO:0007217)5.23236418
4adaptation of signaling pathway (GO:0023058)5.05235363
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.79972054
6viral transcription (GO:0019083)4.58018008
7positive regulation of mitochondrial fission (GO:0090141)4.44408497
8dopamine biosynthetic process (GO:0042416)4.43021625
9glyoxylate metabolic process (GO:0046487)4.42196659
10translational termination (GO:0006415)4.38235946
11protein localization to cilium (GO:0061512)4.24726877
12heterochromatin organization (GO:0070828)4.18076062
13regulation of cilium movement (GO:0003352)4.06483897
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.92828417
15gamma-aminobutyric acid transport (GO:0015812)3.87368322
16nonmotile primary cilium assembly (GO:0035058)3.82887899
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.82114744
18cotranslational protein targeting to membrane (GO:0006613)3.80691124
19protein targeting to ER (GO:0045047)3.74756528
20detection of temperature stimulus (GO:0016048)3.72943805
21behavioral response to nicotine (GO:0035095)3.68802861
22translational elongation (GO:0006414)3.64287705
23establishment of protein localization to endoplasmic reticulum (GO:0072599)3.62035073
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.59632564
25auditory receptor cell differentiation (GO:0042491)3.53629725
26respiratory electron transport chain (GO:0022904)3.53079463
27ribosomal small subunit assembly (GO:0000028)3.52578285
28electron transport chain (GO:0022900)3.52531372
29substrate-independent telencephalic tangential migration (GO:0021826)3.49453148
30substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.49453148
31histone H2A monoubiquitination (GO:0035518)3.49159834
32ribosomal small subunit biogenesis (GO:0042274)3.48480862
33protein localization to endoplasmic reticulum (GO:0070972)3.48015028
34dopamine transport (GO:0015872)3.39010630
35catechol-containing compound biosynthetic process (GO:0009713)3.37945235
36catecholamine biosynthetic process (GO:0042423)3.37945235
37viral life cycle (GO:0019058)3.34454353
38negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.33422493
39detection of temperature stimulus involved in sensory perception (GO:0050961)3.31842208
40detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.31842208
41cellular protein complex disassembly (GO:0043624)3.31676974
42serine family amino acid catabolic process (GO:0009071)3.28785270
43transmission of nerve impulse (GO:0019226)3.22942981
44protein complex biogenesis (GO:0070271)3.21862333
45regulation of dopamine metabolic process (GO:0042053)3.16747631
46regulation of catecholamine metabolic process (GO:0042069)3.16747631
47cardiac right ventricle morphogenesis (GO:0003215)3.16067912
48protein-cofactor linkage (GO:0018065)3.14910635
49epithelial cilium movement (GO:0003351)3.14370440
50termination of RNA polymerase III transcription (GO:0006386)3.12911695
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.12911695
52receptor recycling (GO:0001881)3.12018897
53ATP biosynthetic process (GO:0006754)3.06692275
54somite development (GO:0061053)3.01893462
55mitochondrial respiratory chain complex assembly (GO:0033108)3.00350402
56neuronal action potential propagation (GO:0019227)2.97027916
57ovulation cycle (GO:0042698)2.93737720
58neuronal ion channel clustering (GO:0045161)2.92794898
59hydrogen ion transmembrane transport (GO:1902600)2.92311162
60organelle disassembly (GO:1903008)2.89937819
61histone H2A ubiquitination (GO:0033522)2.89658989
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.87033108
63parturition (GO:0007567)2.86073435
64regulation of mitochondrial fission (GO:0090140)2.84614447
65short-term memory (GO:0007614)2.81130933
66forebrain neuron differentiation (GO:0021879)2.79260348
67basic amino acid transport (GO:0015802)2.78273000
68protein polyglutamylation (GO:0018095)2.77464918
69protein localization to Golgi apparatus (GO:0034067)2.77032761
70maturation of SSU-rRNA (GO:0030490)2.75132107
71response to pheromone (GO:0019236)2.73552881
72protein complex disassembly (GO:0043241)2.73252208
73central nervous system myelination (GO:0022010)2.71858994
74axon ensheathment in central nervous system (GO:0032291)2.71858994
75intraciliary transport (GO:0042073)2.69306626
76somite rostral/caudal axis specification (GO:0032525)2.69294063
77translational initiation (GO:0006413)2.68653051
78ribosomal large subunit biogenesis (GO:0042273)2.67317805
79negative regulation of T-helper cell differentiation (GO:0045623)2.66691594
80negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.66691594
81positive regulation of protein homooligomerization (GO:0032464)2.64166418
82purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.64061008
83cerebellar Purkinje cell differentiation (GO:0021702)2.63461248
84negative regulation of transcription regulatory region DNA binding (GO:2000678)2.63226624
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.63194229
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.63194229
87macromolecular complex disassembly (GO:0032984)2.63098688
88purine nucleoside triphosphate biosynthetic process (GO:0009145)2.61420739
89positive regulation of gastrulation (GO:2000543)2.61137219
90axonal fasciculation (GO:0007413)2.60722973
91synaptic transmission, glutamatergic (GO:0035249)2.59917199
92regulation of female receptivity (GO:0045924)2.57040854
93serotonin metabolic process (GO:0042428)2.54071609
94mitochondrial respiratory chain complex I assembly (GO:0032981)2.53072885
95NADH dehydrogenase complex assembly (GO:0010257)2.53072885
96mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.53072885
97regulation of feeding behavior (GO:0060259)2.52486294
98water-soluble vitamin biosynthetic process (GO:0042364)2.50814261
99regulation of mitochondrial translation (GO:0070129)2.49083589
100negative regulation of alpha-beta T cell differentiation (GO:0046639)2.48687476

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.76682791
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.99077108
3VDR_22108803_ChIP-Seq_LS180_Human2.90020889
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83177720
5TAF15_26573619_Chip-Seq_HEK293_Human2.64122850
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.49438507
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47667225
8GBX2_23144817_ChIP-Seq_PC3_Human2.43052100
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40850011
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32928241
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30498740
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.29180693
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22872907
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.20392303
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.17440554
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16549124
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13591650
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13363034
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12387881
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96995677
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93172763
22REST_21632747_ChIP-Seq_MESCs_Mouse1.92921687
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89316442
24FUS_26573619_Chip-Seq_HEK293_Human1.88736454
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.87560488
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85815763
27MYC_18940864_ChIP-ChIP_HL60_Human1.84204905
28IGF1R_20145208_ChIP-Seq_DFB_Human1.84197787
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82737745
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.82737745
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.79176483
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.76226620
33EWS_26573619_Chip-Seq_HEK293_Human1.75968221
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73696665
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.71743946
36GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.69301924
37ZNF274_21170338_ChIP-Seq_K562_Hela1.68783867
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.59354071
39P300_19829295_ChIP-Seq_ESCs_Human1.57164544
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56842399
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.54159887
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51538622
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51441840
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50812812
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.49567582
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48576426
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47314246
48RNF2_27304074_Chip-Seq_NSC_Mouse1.44892492
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43879045
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43042865
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40987317
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39376246
53AR_21572438_ChIP-Seq_LNCaP_Human1.38627884
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33435031
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33435031
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32281420
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31235168
58IRF1_19129219_ChIP-ChIP_H3396_Human1.29438409
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25267562
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.22224016
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.21235813
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.19200211
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.17429688
64AR_25329375_ChIP-Seq_VCAP_Human1.17304570
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14023884
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14018983
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13428867
68BCAT_22108803_ChIP-Seq_LS180_Human1.13221869
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11014857
70LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10398272
71TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07476537
72TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07027332
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06496760
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04656369
75TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01725283
76NCOR_22424771_ChIP-Seq_293T_Human1.01395574
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00835495
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00652750
79ER_23166858_ChIP-Seq_MCF-7_Human0.98835294
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98403100
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97529746
82CBP_20019798_ChIP-Seq_JUKART_Human0.97529746
83TP53_22573176_ChIP-Seq_HFKS_Human0.97144038
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97130068
85SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97034796
86SMAD3_21741376_ChIP-Seq_EPCs_Human0.95862081
87ETS1_20019798_ChIP-Seq_JURKAT_Human0.95782115
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94898731
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94599033
90STAT3_23295773_ChIP-Seq_U87_Human0.94419780
91MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93932509
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93758515
93SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93739026
94TP53_20018659_ChIP-ChIP_R1E_Mouse0.93000828
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91948492
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91688108
97ELK1_19687146_ChIP-ChIP_HELA_Human0.91282728
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90932674
99TAF2_19829295_ChIP-Seq_ESCs_Human0.90158909
100RING1B_27294783_Chip-Seq_ESCs_Mouse0.90008731

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous3.90569442
2MP0004858_abnormal_nervous_system3.07018863
3MP0004145_abnormal_muscle_electrophysio3.03666132
4MP0009379_abnormal_foot_pigmentation2.93543574
5MP0003787_abnormal_imprinting2.79861855
6MP0002736_abnormal_nociception_after2.59143496
7MP0003890_abnormal_embryonic-extraembry2.56296488
8MP0001968_abnormal_touch/_nociception2.54332657
9MP0004142_abnormal_muscle_tone2.44762327
10MP0003136_yellow_coat_color2.40373542
11MP0004885_abnormal_endolymph2.40247791
12MP0003011_delayed_dark_adaptation2.37981582
13MP0003880_abnormal_central_pattern2.27010527
14MP0006292_abnormal_olfactory_placode2.20842350
15MP0001440_abnormal_grooming_behavior2.17929986
16MP0000778_abnormal_nervous_system2.06577097
17MP0002272_abnormal_nervous_system2.00381374
18MP0002184_abnormal_innervation1.92976743
19MP0009745_abnormal_behavioral_response1.88228238
20MP0003121_genomic_imprinting1.83842021
21MP0003122_maternal_imprinting1.79700844
22MP0002063_abnormal_learning/memory/cond1.71674532
23MP0001727_abnormal_embryo_implantation1.70101266
24MP0000569_abnormal_digit_pigmentation1.69423145
25MP0002572_abnormal_emotion/affect_behav1.68090947
26MP0005551_abnormal_eye_electrophysiolog1.66505986
27MP0001905_abnormal_dopamine_level1.64338551
28MP0003878_abnormal_ear_physiology1.60216611
29MP0005377_hearing/vestibular/ear_phenot1.60216611
30MP0004742_abnormal_vestibular_system1.58451293
31MP0002938_white_spotting1.54171888
32MP0001485_abnormal_pinna_reflex1.53054811
33MP0002163_abnormal_gland_morphology1.50700746
34MP0005084_abnormal_gallbladder_morpholo1.49186407
35MP0000372_irregular_coat_pigmentation1.48426731
36MP0003123_paternal_imprinting1.48079170
37MP0002160_abnormal_reproductive_system1.47650779
38MP0009046_muscle_twitch1.46780928
39MP0001293_anophthalmia1.42592155
40MP0002752_abnormal_somatic_nervous1.41506386
41MP0002557_abnormal_social/conspecific_i1.40985213
42MP0000955_abnormal_spinal_cord1.40964541
43MP0006276_abnormal_autonomic_nervous1.40697072
44MP0001529_abnormal_vocalization1.40500982
45MP0003635_abnormal_synaptic_transmissio1.40492482
46MP0001502_abnormal_circadian_rhythm1.35201108
47MP0004133_heterotaxia1.33598654
48MP0002234_abnormal_pharynx_morphology1.32683915
49MP0008872_abnormal_physiological_respon1.29966388
50MP0008789_abnormal_olfactory_epithelium1.26658218
51MP0006072_abnormal_retinal_apoptosis1.20458804
52MP0002067_abnormal_sensory_capabilities1.20445361
53MP0002928_abnormal_bile_duct1.19619309
54MP0003567_abnormal_fetal_cardiomyocyte1.15686508
55MP0002653_abnormal_ependyma_morphology1.14530702
56MP0002882_abnormal_neuron_morphology1.13796854
57MP0000631_abnormal_neuroendocrine_gland1.10701063
58MP0005195_abnormal_posterior_eye1.10678720
59MP0000427_abnormal_hair_cycle1.09275512
60MP0005379_endocrine/exocrine_gland_phen1.09020138
61MP0002733_abnormal_thermal_nociception1.08905019
62MP0006035_abnormal_mitochondrial_morpho1.06291099
63MP0003119_abnormal_digestive_system1.04836421
64MP0008875_abnormal_xenobiotic_pharmacok1.01109287
65MP0003942_abnormal_urinary_system1.01103084
66MP0000026_abnormal_inner_ear0.98682477
67MP0005253_abnormal_eye_physiology0.98292446
68MP0001486_abnormal_startle_reflex0.98137017
69MP0001986_abnormal_taste_sensitivity0.95690212
70MP0002064_seizures0.95013550
71MP0005389_reproductive_system_phenotype0.94177376
72MP0003861_abnormal_nervous_system0.92305465
73MP0002751_abnormal_autonomic_nervous0.91625965
74MP0004811_abnormal_neuron_physiology0.91587365
75MP0002102_abnormal_ear_morphology0.91137398
76MP0009053_abnormal_anal_canal0.91068562
77MP0009697_abnormal_copulation0.90075488
78MP0002229_neurodegeneration0.89833275
79MP0001286_abnormal_eye_development0.85935590
80MP0002152_abnormal_brain_morphology0.85861429
81MP0005499_abnormal_olfactory_system0.84861209
82MP0005394_taste/olfaction_phenotype0.84861209
83MP0002210_abnormal_sex_determination0.83085579
84MP0001984_abnormal_olfaction0.83020394
85MP0002282_abnormal_trachea_morphology0.82528992
86MP0003937_abnormal_limbs/digits/tail_de0.80391102
87MP0002090_abnormal_vision0.79900668
88MP0003186_abnormal_redox_activity0.79893980
89MP0001919_abnormal_reproductive_system0.79808201
90MP0005391_vision/eye_phenotype0.79736986
91MP0005410_abnormal_fertilization0.79260032
92MP0005386_behavior/neurological_phenoty0.79119148
93MP0004924_abnormal_behavior0.79119148
94MP0002734_abnormal_mechanical_nocicepti0.78650652
95MP0002876_abnormal_thyroid_physiology0.78629825
96MP0008058_abnormal_DNA_repair0.78374123
97MP0001348_abnormal_lacrimal_gland0.76834153
98MP0005187_abnormal_penis_morphology0.75781570
99MP0006036_abnormal_mitochondrial_physio0.75323474
100MP0005646_abnormal_pituitary_gland0.75264481

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)4.33713990
2Abnormality of midbrain morphology (HP:0002418)4.14965572
3Molar tooth sign on MRI (HP:0002419)4.14965572
4Diastasis recti (HP:0001540)3.98648822
5Reticulocytopenia (HP:0001896)3.90389969
6Medial flaring of the eyebrow (HP:0010747)3.60716305
7Pancreatic fibrosis (HP:0100732)3.57955684
8Acute necrotizing encephalopathy (HP:0006965)3.43871497
9Pendular nystagmus (HP:0012043)3.37308924
10Poor coordination (HP:0002370)3.36213236
11Abnormality of the corticospinal tract (HP:0002492)3.35886923
12Nephronophthisis (HP:0000090)3.35822955
13Gait imbalance (HP:0002141)3.32977175
14Abnormality of cells of the erythroid lineage (HP:0012130)3.27692066
15Congenital primary aphakia (HP:0007707)3.18473023
16Pancreatic cysts (HP:0001737)3.13334258
17Sclerocornea (HP:0000647)3.11977257
18Nephrogenic diabetes insipidus (HP:0009806)3.02009852
19Abnormality of the labia minora (HP:0012880)3.01599169
20Increased hepatocellular lipid droplets (HP:0006565)3.00302321
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99364822
22Mitochondrial inheritance (HP:0001427)2.98735961
23Aplastic anemia (HP:0001915)2.98310806
24Abnormality of the renal medulla (HP:0100957)2.97093745
25Abnormal hair whorl (HP:0010721)2.94652266
26Colon cancer (HP:0003003)2.93472712
27Acute encephalopathy (HP:0006846)2.92856122
28True hermaphroditism (HP:0010459)2.87934320
29Abnormality of renal resorption (HP:0011038)2.84533833
30Abnormal mitochondria in muscle tissue (HP:0008316)2.83267339
31Progressive macrocephaly (HP:0004481)2.82759905
32Abnormal number of erythroid precursors (HP:0012131)2.75936946
33Hypogonadotrophic hypogonadism (HP:0000044)2.75244936
34Renal Fanconi syndrome (HP:0001994)2.64556057
35Congenital stationary night blindness (HP:0007642)2.55146813
36Chromsome breakage (HP:0040012)2.49854024
37Genital tract atresia (HP:0001827)2.49576956
38Lipid accumulation in hepatocytes (HP:0006561)2.48962052
39Vaginal atresia (HP:0000148)2.47452167
40Specific learning disability (HP:0001328)2.46575074
41Increased CSF lactate (HP:0002490)2.41120608
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.32104722
43Hepatic necrosis (HP:0002605)2.30586623
44Hepatocellular necrosis (HP:0001404)2.30335661
45Metaphyseal dysplasia (HP:0100255)2.30288762
46Chorioretinal atrophy (HP:0000533)2.29372346
47Spastic tetraparesis (HP:0001285)2.27045094
48Abnormality of the nasal septum (HP:0000419)2.24643879
49Osteomalacia (HP:0002749)2.22570126
50Respiratory difficulties (HP:0002880)2.20729626
51Decreased testicular size (HP:0008734)2.19551783
52Cerebral edema (HP:0002181)2.19454764
53Abolished electroretinogram (ERG) (HP:0000550)2.16905565
54Poor suck (HP:0002033)2.15650105
55Polyphagia (HP:0002591)2.12915410
56Macrocytic anemia (HP:0001972)2.12624521
57Impulsivity (HP:0100710)2.11408230
58Sleep apnea (HP:0010535)2.07345383
59Postaxial foot polydactyly (HP:0001830)2.02629494
60Neoplasm of the adrenal cortex (HP:0100641)2.01641789
61Abnormal urine phosphate concentration (HP:0012599)2.01338272
62Hyperphosphaturia (HP:0003109)2.01100932
63Abnormality of the renal collecting system (HP:0004742)1.99157535
64Meckel diverticulum (HP:0002245)1.98193296
65Optic disc pallor (HP:0000543)1.97326548
66Exertional dyspnea (HP:0002875)1.96931279
67Morphological abnormality of the pyramidal tract (HP:0002062)1.96501737
68Amyotrophic lateral sclerosis (HP:0007354)1.94245765
69Abnormality of the lower motor neuron (HP:0002366)1.94097224
70Cystic liver disease (HP:0006706)1.93629949
71Duplicated collecting system (HP:0000081)1.92070489
72Pallor (HP:0000980)1.91469163
73Broad foot (HP:0001769)1.90504991
74Abnormality of the renal cortex (HP:0011035)1.90158095
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88408719
76Proximal tubulopathy (HP:0000114)1.88111516
77Drooling (HP:0002307)1.86547339
78Anophthalmia (HP:0000528)1.85175973
79Abnormality of the ileum (HP:0001549)1.83965119
80Hepatoblastoma (HP:0002884)1.83243471
81Hyperglycinemia (HP:0002154)1.83235995
82Aganglionic megacolon (HP:0002251)1.81575285
83Septo-optic dysplasia (HP:0100842)1.80966830
84Abnormal pancreas size (HP:0012094)1.80596894
85Aplasia/Hypoplasia of the tongue (HP:0010295)1.79269953
86Postaxial hand polydactyly (HP:0001162)1.79051869
87Abnormality of urine glucose concentration (HP:0011016)1.77254367
88Glycosuria (HP:0003076)1.77254367
89Anosmia (HP:0000458)1.77051008
90Congenital, generalized hypertrichosis (HP:0004540)1.75390007
91Anencephaly (HP:0002323)1.75068491
92Abnormality of the aortic arch (HP:0012303)1.74993225
93Male pseudohermaphroditism (HP:0000037)1.72998890
94Progressive cerebellar ataxia (HP:0002073)1.72050604
95Genetic anticipation (HP:0003743)1.71563354
96Clubbing of toes (HP:0100760)1.70954803
97Aplasia/Hypoplasia of the lens (HP:0008063)1.68459634
98Abnormality of lateral ventricle (HP:0030047)1.67443426
99Absent thumb (HP:0009777)1.66890327
100Excessive salivation (HP:0003781)1.66738657

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DYRK33.29992440
2MAP3K42.89685257
3TAF12.56582006
4MARK12.42862973
5GRK12.37720892
6NME12.36682641
7VRK22.33400704
8EIF2AK12.14203526
9DYRK22.11482838
10ADRBK21.98878890
11NTRK21.90967962
12WNK31.82535614
13PRKCG1.79612199
14PNCK1.77275589
15VRK11.75633050
16FRK1.74876655
17TNIK1.73715350
18NUAK11.73500873
19BMPR1B1.70512575
20MAPK151.68982008
21MAP3K101.67923814
22TLK11.67104831
23SGK21.65852095
24MAPK131.62161302
25SGK2231.56655391
26SGK4941.56655391
27STK241.46573767
28MKNK21.46173647
29CASK1.41462641
30NLK1.40544268
31WNK41.36330201
32STK391.33032316
33RPS6KA21.32535827
34MINK11.32495601
35NTRK31.30920673
36BCKDK1.28861673
37MAP2K71.22013529
38EPHB21.17278969
39EPHA41.16743801
40DMPK1.12079467
41ZAK1.11275169
42PINK11.09260778
43CDC71.04355271
44INSRR1.03222921
45PAK31.01508328
46DYRK1A1.00535524
47PRKCQ0.95581747
48BRD40.91912277
49TIE10.91347941
50RPS6KA60.90758689
51DAPK20.88220949
52OXSR10.87885757
53EIF2AK30.82515932
54CSNK1G20.82258805
55PLK30.81913081
56MAP2K40.79252426
57STK30.78991218
58MAP4K20.78952468
59TGFBR10.76994861
60PLK40.76320137
61GRK50.76296579
62LATS20.73712787
63SGK30.69341644
64PRKCZ0.65054535
65RPS6KC10.64812333
66RPS6KL10.64812333
67MAPKAPK30.64432677
68ACVR1B0.63571892
69PBK0.63432266
70TAOK30.62369552
71CAMK40.62230505
72PASK0.61913235
73CAMK2A0.61418599
74ABL20.59837342
75TSSK60.59138458
76MKNK10.58838884
77ADRBK10.58560105
78SGK10.58447278
79PRKCE0.57927961
80STK38L0.57123083
81PLK10.56682518
82MARK20.55148757
83IRAK20.53828811
84MAP3K120.53483210
85PRKCD0.52079373
86PRKACA0.51542816
87RPS6KA50.51195298
88MAPKAPK50.51140695
89PLK20.50775095
90STK110.50558718
91PRKG10.49342218
92CHUK0.49001866
93PTK2B0.47364087
94ERBB20.46202594
95NEK90.45756065
96MAP3K110.45693156
97RPS6KA10.44752800
98AURKA0.41606672
99TTK0.40733344
100TEC0.38720455

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.62850331
2Oxidative phosphorylation_Homo sapiens_hsa001904.43965538
3Parkinsons disease_Homo sapiens_hsa050124.02101634
4Cardiac muscle contraction_Homo sapiens_hsa042602.92934123
5Sulfur relay system_Homo sapiens_hsa041222.82164540
6Huntingtons disease_Homo sapiens_hsa050162.79925214
7Alzheimers disease_Homo sapiens_hsa050102.77117526
8Fatty acid biosynthesis_Homo sapiens_hsa000612.66696130
9RNA polymerase_Homo sapiens_hsa030202.58226626
10Protein export_Homo sapiens_hsa030602.47351832
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.19726159
12Nicotine addiction_Homo sapiens_hsa050331.90519637
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83088206
14Phototransduction_Homo sapiens_hsa047441.71991416
15Steroid biosynthesis_Homo sapiens_hsa001001.64124888
16Homologous recombination_Homo sapiens_hsa034401.53741592
17Morphine addiction_Homo sapiens_hsa050321.49726618
18Collecting duct acid secretion_Homo sapiens_hsa049661.45242267
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41927611
20Folate biosynthesis_Homo sapiens_hsa007901.37329095
21Pyrimidine metabolism_Homo sapiens_hsa002401.27530137
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27119571
23Fanconi anemia pathway_Homo sapiens_hsa034601.25518439
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23642509
25Circadian entrainment_Homo sapiens_hsa047131.22044691
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19860963
27Proteasome_Homo sapiens_hsa030501.19477710
28Glutamatergic synapse_Homo sapiens_hsa047241.18882473
29Dorso-ventral axis formation_Homo sapiens_hsa043201.17537841
30Purine metabolism_Homo sapiens_hsa002301.11632592
31Caffeine metabolism_Homo sapiens_hsa002321.10325510
32Linoleic acid metabolism_Homo sapiens_hsa005911.05779237
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05180812
34GABAergic synapse_Homo sapiens_hsa047271.03189445
35Peroxisome_Homo sapiens_hsa041460.99607301
36Basal transcription factors_Homo sapiens_hsa030220.98060152
37Cocaine addiction_Homo sapiens_hsa050300.97856852
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96909403
39Axon guidance_Homo sapiens_hsa043600.95737814
40Butanoate metabolism_Homo sapiens_hsa006500.94924584
41Renin secretion_Homo sapiens_hsa049240.94542592
42Steroid hormone biosynthesis_Homo sapiens_hsa001400.93479882
43Selenocompound metabolism_Homo sapiens_hsa004500.91030732
44Amphetamine addiction_Homo sapiens_hsa050310.90530516
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88901299
46Synaptic vesicle cycle_Homo sapiens_hsa047210.88623781
47Taste transduction_Homo sapiens_hsa047420.85647437
48Long-term depression_Homo sapiens_hsa047300.85314041
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.82767852
50Olfactory transduction_Homo sapiens_hsa047400.82657673
51Dopaminergic synapse_Homo sapiens_hsa047280.82243828
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81888261
53Base excision repair_Homo sapiens_hsa034100.81018755
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.79809936
55Arginine and proline metabolism_Homo sapiens_hsa003300.78067640
56Basal cell carcinoma_Homo sapiens_hsa052170.75390864
57Serotonergic synapse_Homo sapiens_hsa047260.74260929
58Asthma_Homo sapiens_hsa053100.72098497
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70641882
60Nitrogen metabolism_Homo sapiens_hsa009100.67070956
61Retinol metabolism_Homo sapiens_hsa008300.66925393
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66461198
63Insulin secretion_Homo sapiens_hsa049110.66127647
64Alcoholism_Homo sapiens_hsa050340.65309810
65Ether lipid metabolism_Homo sapiens_hsa005650.64563852
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63661522
67RNA degradation_Homo sapiens_hsa030180.59882070
68Calcium signaling pathway_Homo sapiens_hsa040200.58400605
69Metabolic pathways_Homo sapiens_hsa011000.58187150
70Long-term potentiation_Homo sapiens_hsa047200.56555776
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.56192177
72RNA transport_Homo sapiens_hsa030130.55979850
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55625116
74Cholinergic synapse_Homo sapiens_hsa047250.55449038
75Chemical carcinogenesis_Homo sapiens_hsa052040.54324112
76Wnt signaling pathway_Homo sapiens_hsa043100.52672665
77DNA replication_Homo sapiens_hsa030300.52531731
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51909003
79Mismatch repair_Homo sapiens_hsa034300.50063656
80Fatty acid metabolism_Homo sapiens_hsa012120.47972308
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46434331
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44446252
83Oocyte meiosis_Homo sapiens_hsa041140.44128291
84Mineral absorption_Homo sapiens_hsa049780.38267986
85Melanogenesis_Homo sapiens_hsa049160.38072310
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37671895
87Regulation of autophagy_Homo sapiens_hsa041400.36502062
88Autoimmune thyroid disease_Homo sapiens_hsa053200.33788885
89Nucleotide excision repair_Homo sapiens_hsa034200.32530859
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32387728
91Spliceosome_Homo sapiens_hsa030400.32355750
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30684052
93Oxytocin signaling pathway_Homo sapiens_hsa049210.30643926
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30318837
95Tryptophan metabolism_Homo sapiens_hsa003800.30300467
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28877609
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28399233
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28165066
99Hedgehog signaling pathway_Homo sapiens_hsa043400.27719541
100cAMP signaling pathway_Homo sapiens_hsa040240.25597254

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