NUMB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)5.17469537
2modulation by symbiont of host defense response (GO:0052031)5.17469537
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.17469537
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.17469537
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.17469537
6modulation by symbiont of host immune response (GO:0052553)5.17469537
7response to peptidoglycan (GO:0032494)4.87908473
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.84808395
9negative regulation of cell killing (GO:0031342)4.84808395
10neutrophil activation involved in immune response (GO:0002283)4.75781138
11positive regulation of gamma-delta T cell activation (GO:0046645)4.74297058
12macrophage activation involved in immune response (GO:0002281)4.69654970
13negative regulation of interleukin-12 production (GO:0032695)4.64913464
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.62240427
15detection of molecule of bacterial origin (GO:0032490)4.57537133
16positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.20520914
17detection of other organism (GO:0098543)4.17711279
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.17240129
19cellular extravasation (GO:0045123)4.14821737
20detection of external biotic stimulus (GO:0098581)3.95529561
21regulation of B cell receptor signaling pathway (GO:0050855)3.91118416
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.85527194
23alpha-linolenic acid metabolic process (GO:0036109)3.83531701
24L-phenylalanine catabolic process (GO:0006559)3.82912455
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.82912455
26neutrophil activation (GO:0042119)3.82030505
27antigen processing and presentation of endogenous antigen (GO:0019883)3.81912801
28detection of bacterium (GO:0016045)3.78171612
29immunoglobulin mediated immune response (GO:0016064)3.74786615
30granulocyte activation (GO:0036230)3.72268723
31protein carboxylation (GO:0018214)3.65371497
32peptidyl-glutamic acid carboxylation (GO:0017187)3.65371497
33complement activation, alternative pathway (GO:0006957)3.64480716
34urea metabolic process (GO:0019627)3.63973932
35urea cycle (GO:0000050)3.63973932
36lipopolysaccharide-mediated signaling pathway (GO:0031663)3.63628093
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.61352884
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.60893162
39L-phenylalanine metabolic process (GO:0006558)3.60893162
40regulation of protein activation cascade (GO:2000257)3.60887546
41macrophage activation (GO:0042116)3.58736382
42microglial cell activation (GO:0001774)3.56311976
43lysine catabolic process (GO:0006554)3.52745958
44lysine metabolic process (GO:0006553)3.52745958
45high-density lipoprotein particle remodeling (GO:0034375)3.51348509
46regulation of gamma-delta T cell activation (GO:0046643)3.49117861
47regulation of complement activation (GO:0030449)3.48177464
48response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.47986799
49response to host immune response (GO:0052572)3.47986799
50leukocyte aggregation (GO:0070486)3.47580950
51antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.47302634
52detection of biotic stimulus (GO:0009595)3.47286781
53reverse cholesterol transport (GO:0043691)3.40540533
54phospholipid efflux (GO:0033700)3.40430349
55negative regulation of fibrinolysis (GO:0051918)3.38498279
56myeloid cell activation involved in immune response (GO:0002275)3.36418141
57aromatic amino acid family catabolic process (GO:0009074)3.36198053
58regulation of mast cell degranulation (GO:0043304)3.35297322
59phospholipid homeostasis (GO:0055091)3.34620947
60regulation of triglyceride catabolic process (GO:0010896)3.34275482
61plasma lipoprotein particle clearance (GO:0034381)3.32647097
62response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.32510356
63response to host (GO:0075136)3.32510356
64response to host defenses (GO:0052200)3.32510356
65neutrophil mediated immunity (GO:0002446)3.28941761
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26355818
67germinal center formation (GO:0002467)3.26075425
68negative regulation of lymphocyte mediated immunity (GO:0002707)3.23870726
69regulation of cholesterol homeostasis (GO:2000188)3.22226102
70regulation of mast cell activation involved in immune response (GO:0033006)3.18186995
71nitrogen cycle metabolic process (GO:0071941)3.17935344
72bile acid biosynthetic process (GO:0006699)3.17848818
73cellular response to type I interferon (GO:0071357)3.15208317
74type I interferon signaling pathway (GO:0060337)3.15208317
75negative regulation of cholesterol transport (GO:0032375)3.14007248
76negative regulation of sterol transport (GO:0032372)3.14007248
77response to type I interferon (GO:0034340)3.12571525
78response to muramyl dipeptide (GO:0032495)3.12216043
79respiratory burst (GO:0045730)3.11942982
80positive regulation of mast cell activation (GO:0033005)3.11400070
81kynurenine metabolic process (GO:0070189)3.09832695
82regulation of mast cell activation (GO:0033003)3.09652740
83production of molecular mediator involved in inflammatory response (GO:0002532)3.09320689
84cholesterol efflux (GO:0033344)3.08834978
85leukocyte migration involved in inflammatory response (GO:0002523)3.08725576
86sulfur amino acid catabolic process (GO:0000098)3.08228341
87regulation of fibrinolysis (GO:0051917)3.07271736
88interferon-gamma-mediated signaling pathway (GO:0060333)3.05575390
89triglyceride homeostasis (GO:0070328)3.05232432
90acylglycerol homeostasis (GO:0055090)3.05232432
91hemidesmosome assembly (GO:0031581)3.05066832
92plasma lipoprotein particle assembly (GO:0034377)3.04068338
93T-helper 1 type immune response (GO:0042088)3.03876796
94positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.02997614
95regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.02583647
96positive regulation of toll-like receptor signaling pathway (GO:0034123)3.02206055
97protein-lipid complex assembly (GO:0065005)3.00966396
98regulation of T-helper 2 cell differentiation (GO:0045628)3.00861211
99regulation of leukocyte degranulation (GO:0043300)3.00794525
100positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.99915824
101regulation of myeloid leukocyte mediated immunity (GO:0002886)2.97475131
102negative regulation of T cell mediated immunity (GO:0002710)2.97335037
103response to interleukin-15 (GO:0070672)2.97274022
104indole-containing compound catabolic process (GO:0042436)2.95878684
105indolalkylamine catabolic process (GO:0046218)2.95878684
106tryptophan catabolic process (GO:0006569)2.95878684
107negative regulation of leukocyte mediated immunity (GO:0002704)2.95787545
108positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.95080305
109glyoxylate metabolic process (GO:0046487)2.94163783
110regulation of interferon-alpha production (GO:0032647)2.93203968
111bile acid and bile salt transport (GO:0015721)2.92679362
112positive regulation of cellular amide metabolic process (GO:0034250)2.92644993
113defense response to protozoan (GO:0042832)2.92370730
114positive regulation of interferon-alpha production (GO:0032727)2.91828890
115regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.91355969
116plasma lipoprotein particle remodeling (GO:0034369)2.91066331
117protein-lipid complex remodeling (GO:0034368)2.91066331
118macromolecular complex remodeling (GO:0034367)2.91066331
119regulation of tolerance induction (GO:0002643)2.90278363
120bile acid metabolic process (GO:0008206)2.90240270
121low-density lipoprotein particle clearance (GO:0034383)2.90170830
122positive regulation of lipoprotein lipase activity (GO:0051006)2.89715909
123positive regulation of triglyceride lipase activity (GO:0061365)2.89715909
124negative regulation of cytokine production involved in immune response (GO:0002719)2.87715426
125drug catabolic process (GO:0042737)2.86688538
126cholesterol homeostasis (GO:0042632)2.84755726
127neutrophil chemotaxis (GO:0030593)2.84285276
128antigen processing and presentation via MHC class Ib (GO:0002475)2.83937614
129tryptophan metabolic process (GO:0006568)2.83250024
130regulation of T cell tolerance induction (GO:0002664)2.83093759
131B cell mediated immunity (GO:0019724)2.82232720
132regulation of cholesterol esterification (GO:0010872)2.82161252
133sterol homeostasis (GO:0055092)2.82115458
134apoptotic cell clearance (GO:0043277)2.81899244
135negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.81359735
136myeloid leukocyte activation (GO:0002274)2.81030692
137regulation of bile acid biosynthetic process (GO:0070857)2.80729885
138myeloid leukocyte mediated immunity (GO:0002444)2.80230731
139positive regulation of lipid catabolic process (GO:0050996)2.80119557
140lipoprotein metabolic process (GO:0042157)2.80103471
141regulation of gamma-delta T cell differentiation (GO:0045586)2.79853457
142cysteine metabolic process (GO:0006534)2.78375913
143amino-acid betaine metabolic process (GO:0006577)2.77057745
144neutrophil migration (GO:1990266)2.76982537
145regulation of dendritic cell antigen processing and presentation (GO:0002604)2.76192990
146cellular glucuronidation (GO:0052695)2.74880844
147response to protozoan (GO:0001562)2.73497281
148intestinal cholesterol absorption (GO:0030299)2.71882002
149regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.71659239
150regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.71345917
151leukocyte degranulation (GO:0043299)2.71168140
152dicarboxylic acid biosynthetic process (GO:0043650)2.69520222
153positive regulation of mast cell degranulation (GO:0043306)2.69442377
154positive regulation of mast cell activation involved in immune response (GO:0033008)2.69442377
155positive regulation of NF-kappaB import into nucleus (GO:0042346)2.66681494
156negative regulation of lipase activity (GO:0060192)2.66637835
157negative regulation of interleukin-6 production (GO:0032715)2.66515718
158fibrinolysis (GO:0042730)2.65328598
159homocysteine metabolic process (GO:0050667)2.64612721
160negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.63597695
161negative regulation of T-helper cell differentiation (GO:0045623)2.63597695
162tolerance induction (GO:0002507)2.62701704
163regulation of interleukin-8 biosynthetic process (GO:0045414)2.62682383
164complement activation (GO:0006956)2.62577399
165cellular response to interleukin-15 (GO:0071350)2.62311155
166positive regulation of interferon-beta production (GO:0032728)2.61285190
167positive regulation of type 2 immune response (GO:0002830)2.60901585
168hormone catabolic process (GO:0042447)2.59643067
169tooth mineralization (GO:0034505)2.59095803
170positive regulation of fatty acid biosynthetic process (GO:0045723)2.58060094
171regulation of interferon-beta biosynthetic process (GO:0045357)2.57712706
172complement activation, classical pathway (GO:0006958)2.54884270
173bundle of His cell to Purkinje myocyte communication (GO:0086069)2.54237918
174protein-lipid complex subunit organization (GO:0071825)2.47262956
175lipid homeostasis (GO:0055088)2.47236740
176ethanol oxidation (GO:0006069)2.46817289
177plasma lipoprotein particle organization (GO:0071827)2.45270687
178glutamate metabolic process (GO:0006536)2.44796557
179positive regulation of fatty acid beta-oxidation (GO:0032000)2.43818320
180transcytosis (GO:0045056)2.43752358
181uronic acid metabolic process (GO:0006063)2.43629781
182glucuronate metabolic process (GO:0019585)2.43629781
183regulation of cholesterol storage (GO:0010885)2.41864028
184epoxygenase P450 pathway (GO:0019373)2.41412651
185disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.39431198
186killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.39431198
187tyrosine metabolic process (GO:0006570)2.38314940
188aspartate family amino acid catabolic process (GO:0009068)2.37376538
1892-oxoglutarate metabolic process (GO:0006103)2.36882691
190positive regulation of hemostasis (GO:1900048)2.35449801
191positive regulation of blood coagulation (GO:0030194)2.35449801
192protein activation cascade (GO:0072376)2.35059800
193serine family amino acid catabolic process (GO:0009071)2.33228829
194negative regulation of protein activation cascade (GO:2000258)2.32635500
195positive regulation of triglyceride metabolic process (GO:0090208)2.32114491
196cellular modified amino acid catabolic process (GO:0042219)2.31946627
197fatty acid beta-oxidation (GO:0006635)2.31941805
198growth hormone receptor signaling pathway (GO:0060396)2.31045576
199cholesterol transport (GO:0030301)2.30905515

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.64818843
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.17793559
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.80557327
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.75812169
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.26496393
6NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.87333545
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.81299086
8* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.80589213
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.78247689
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.63775830
11* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.54883329
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.42034741
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34504316
14GATA1_22025678_ChIP-Seq_K562_Human2.34364386
15SPI1_23547873_ChIP-Seq_NB4_Human2.22314527
16CLOCK_20551151_ChIP-Seq_293T_Human2.09636776
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02626965
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.01694323
19VDR_24763502_ChIP-Seq_THP-1_Human2.01405580
20EGR1_19374776_ChIP-ChIP_THP-1_Human1.96783433
21SCL_19346495_ChIP-Seq_HPC-7_Human1.96576575
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95585619
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.95194214
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.91361264
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.89458506
26MYB_26560356_Chip-Seq_TH2_Human1.87821660
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87531269
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.85042981
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83717313
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83424776
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79947620
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.79578494
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.73514132
34* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69063757
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.68485040
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62524557
37MAF_26560356_Chip-Seq_TH1_Human1.60585261
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.60372290
39MYB_26560356_Chip-Seq_TH1_Human1.59233076
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57331077
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57216579
42FOXA2_19822575_ChIP-Seq_HepG2_Human1.55871173
43* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49190418
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47032151
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46954922
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46594817
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45947400
48PU_27001747_Chip-Seq_BMDM_Mouse1.44232246
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.42853794
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42787288
51GATA3_27048872_Chip-Seq_THYMUS_Human1.40758616
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39694699
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38911401
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38630717
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38176236
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37160585
57VDR_21846776_ChIP-Seq_THP-1_Human1.37029661
58* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35441723
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.34925874
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.34902259
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33396699
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32261643
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31958786
64* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30962442
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30435241
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30214102
67GATA3_26560356_Chip-Seq_TH2_Human1.27652494
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26596153
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25186280
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24520280
71UTX_26944678_Chip-Seq_JUKART_Human1.24494652
72TCF7_22412390_ChIP-Seq_EML_Mouse1.23999198
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22839760
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19698290
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19206512
76* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18752576
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17937784
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.17806621
79RUNX_20019798_ChIP-Seq_JUKART_Human1.16909415
80AHR_22903824_ChIP-Seq_MCF-7_Human1.16022756
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15658404
82CDX2_20551321_ChIP-Seq_CACO-2_Human1.15345797
83IRF8_22096565_ChIP-ChIP_GC-B_Human1.13116475
84CJUN_26792858_Chip-Seq_BT549_Human1.12789467
85VDR_24787735_ChIP-Seq_THP-1_Human1.12756447
86TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12398720
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10335258
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09988109
89CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09836027
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.09549552
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09246603
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07989519
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07318144
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07229399
95GATA2_19941826_ChIP-Seq_K562_Human1.06903874
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06837470
97TBX20_22328084_ChIP-Seq_HEART_Mouse1.06723871
98TBX20_22080862_ChIP-Seq_HEART_Mouse1.06723871
99* GATA4_25053715_ChIP-Seq_YYC3_Human1.06019704
100NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05810183
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05810183
102GATA1_19941826_ChIP-Seq_K562_Human1.05787013
103PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05370267
104KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05280765
105ESR1_20079471_ChIP-ChIP_T-47D_Human1.03808307
106SOX2_20726797_ChIP-Seq_SW620_Human1.03505250
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01515693
108RACK7_27058665_Chip-Seq_MCF-7_Human1.00943280
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00828347
110ELK3_25401928_ChIP-Seq_HUVEC_Human1.00550850
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00511186
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99973328
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99161153
114ARNT_22903824_ChIP-Seq_MCF-7_Human0.97928792
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96668505
116* SPI1_23127762_ChIP-Seq_K562_Human0.96593926
117MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96260250
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95495205
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94792329
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94787461
121BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93979583
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92760000
123JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92352822
124RXR_22108803_ChIP-Seq_LS180_Human0.92114704
125MAF_26560356_Chip-Seq_TH2_Human0.91820787
126LXR_22292898_ChIP-Seq_THP-1_Human0.91745216
127* HNF4A_19822575_ChIP-Seq_HepG2_Human0.90072368
128GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89834651
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89328821
130TP53_16413492_ChIP-PET_HCT116_Human0.89049082
131* KDM2B_26808549_Chip-Seq_DND41_Human0.88104333
132GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86978013
133KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86472282
134JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84912339
135HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84436020
136SMAD_19615063_ChIP-ChIP_OVARY_Human0.84337824
137RUNX1_27514584_Chip-Seq_MCF-7_Human0.84312687
138HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82971590
139ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82960656
140FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.82831276
141SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82802047
142GATA6_25053715_ChIP-Seq_YYC3_Human0.82265038
143FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80196703
144P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79835353
145MYC_22102868_ChIP-Seq_BL_Human0.79788256
146ZNF263_19887448_ChIP-Seq_K562_Human0.79685808
147TP63_23658742_ChIP-Seq_EP156T_Human0.79472211
148* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79206938
149SMRT_27268052_Chip-Seq_Bcells_Human0.79097303
150TCF4_18268006_ChIP-ChIP_LS174T_Human0.78462825
151* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78095318
152PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78045566
153GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78002782
154VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77989486
155KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77812160
156KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77240702
157SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.74807214
158SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.74807214
159ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72826607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.42215836
2MP0002139_abnormal_hepatobiliary_system4.47732148
3MP0005085_abnormal_gallbladder_physiolo4.27514926
4MP0005365_abnormal_bile_salt3.84275829
5MP0008875_abnormal_xenobiotic_pharmacok3.34735731
6MP0001835_abnormal_antigen_presentation3.30073326
7MP0009840_abnormal_foam_cell2.97939252
8MP0003252_abnormal_bile_duct2.93416445
9MP0003191_abnormal_cellular_cholesterol2.91105076
10MP0009785_altered_susceptibility_to2.85076344
11MP0010329_abnormal_lipoprotein_level2.70549827
12MP0002148_abnormal_hypersensitivity_rea2.63651227
13MP0005000_abnormal_immune_tolerance2.61479933
14MP0005387_immune_system_phenotype2.52780473
15MP0001790_abnormal_immune_system2.52780473
16MP0005671_abnormal_response_to2.52719040
17MP0005025_abnormal_response_to2.52589742
18MP0001800_abnormal_humoral_immune2.41697758
19MP0002452_abnormal_antigen_presenting2.29834333
20MP0002723_abnormal_immune_serum2.27994065
21MP0003705_abnormal_hypodermis_morpholog2.26296331
22MP0000685_abnormal_immune_system2.22552301
23MP0003300_gastrointestinal_ulcer2.22166016
24MP0002254_reproductive_system_inflammat2.15149419
25MP0001666_abnormal_nutrient_absorption2.11932240
26MP0010368_abnormal_lymphatic_system2.11382903
27MP0002420_abnormal_adaptive_immunity2.07457454
28MP0001819_abnormal_immune_cell2.06410980
29MP0003806_abnormal_nucleotide_metabolis1.99887474
30MP0003303_peritoneal_inflammation1.96925142
31MP0002405_respiratory_system_inflammati1.90595557
32MP0005083_abnormal_biliary_tract1.85439147
33MP0010155_abnormal_intestine_physiology1.83660913
34MP0005167_abnormal_blood-brain_barrier1.73158837
35MP0006054_spinal_hemorrhage1.71653882
36MP0003566_abnormal_cell_adhesion1.69480811
37MP0008260_abnormal_autophagy1.67860903
38MP0005332_abnormal_amino_acid1.65687904
39MP0000609_abnormal_liver_physiology1.65602890
40MP0004272_abnormal_basement_membrane1.57235947
41MP0003724_increased_susceptibility_to1.55371187
42MP0002998_abnormal_bone_remodeling1.54544271
43MP0002118_abnormal_lipid_homeostasis1.54127924
44MP0005058_abnormal_lysosome_morphology1.53352556
45MP0004019_abnormal_vitamin_homeostasis1.51788780
46MP0000716_abnormal_immune_system1.50201893
47MP0002138_abnormal_hepatobiliary_system1.50054200
48MP0005451_abnormal_body_composition1.45190733
49MP0000858_altered_metastatic_potential1.44522877
50MP0000465_gastrointestinal_hemorrhage1.43019298
51MP0010234_abnormal_vibrissa_follicle1.42673945
52MP0002398_abnormal_bone_marrow1.39703897
53MP0003763_abnormal_thymus_physiology1.35087279
54MP0009333_abnormal_splenocyte_physiolog1.33486286
55MP0003075_altered_response_to1.33431830
56MP0005310_abnormal_salivary_gland1.32060105
57MP0003195_calcinosis1.29760907
58MP0002837_dystrophic_cardiac_calcinosis1.29445202
59MP0006082_CNS_inflammation1.29192275
60MP0003448_altered_tumor_morphology1.28124572
61MP0005319_abnormal_enzyme/_coenzyme1.28051975
62MP0003172_abnormal_lysosome_physiology1.27172551
63MP0001545_abnormal_hematopoietic_system1.26305562
64MP0005397_hematopoietic_system_phenotyp1.26305562
65MP0004084_abnormal_cardiac_muscle1.26182394
66MP0000604_amyloidosis1.25033169
67MP0004130_abnormal_muscle_cell1.23657113
68MP0000689_abnormal_spleen_morphology1.21643518
69MP0005023_abnormal_wound_healing1.19008515
70MP0003436_decreased_susceptibility_to1.17445387
71MP0005670_abnormal_white_adipose1.17102784
72MP0002132_abnormal_respiratory_system1.16182713
73MP0002429_abnormal_blood_cell1.15856450
74MP0000767_abnormal_smooth_muscle1.15562816
75MP0002722_abnormal_immune_system1.15331982
76MP0003183_abnormal_peptide_metabolism1.14104898
77MP0009643_abnormal_urine_homeostasis1.12449776
78MP0003690_abnormal_glial_cell1.11738560
79MP0001853_heart_inflammation1.11357197
80MP0009053_abnormal_anal_canal1.10156987
81MP0003866_abnormal_defecation1.09598704
82MP0001958_emphysema1.09181509
83MP0009764_decreased_sensitivity_to1.08712134
84MP0008438_abnormal_cutaneous_collagen1.08542953
85MP0005464_abnormal_platelet_physiology1.08263832
86MP0008961_abnormal_basal_metabolism1.07405569
87MP0000343_altered_response_to1.07277632
88MP0005166_decreased_susceptibility_to1.06128927
89MP0001879_abnormal_lymphatic_vessel1.04871310
90MP0003091_abnormal_cell_migration1.04772492
91MP0003828_pulmonary_edema1.03076315
92MP0005584_abnormal_enzyme/coenzyme_acti1.02840935
93MP0009384_cardiac_valve_regurgitation1.01056039
94MP0003045_fibrosis1.00124873
95MP0004883_abnormal_blood_vessel0.99542868
96MP0005390_skeleton_phenotype0.99188533
97MP0001533_abnormal_skeleton_physiology0.99153234
98MP0004185_abnormal_adipocyte_glucose0.98792468
99MP0002277_abnormal_respiratory_mucosa0.98747656
100MP0004947_skin_inflammation0.98506877
101MP0002971_abnormal_brown_adipose0.97401224
102MP0008469_abnormal_protein_level0.95090778
103MP0004264_abnormal_extraembryonic_tissu0.94672581
104MP0005666_abnormal_adipose_tissue0.94249409
105MP0006138_congestive_heart_failure0.93339942
106MP0002877_abnormal_melanocyte_morpholog0.93305930
107MP0003453_abnormal_keratinocyte_physiol0.92374981
108MP0005164_abnormal_response_to0.92342785
109MP0002419_abnormal_innate_immunity0.90078341
110MP0002166_altered_tumor_susceptibility0.89365918
111MP0000598_abnormal_liver_morphology0.88722093
112MP0009278_abnormal_bone_marrow0.88476940
113MP0001851_eye_inflammation0.87662041
114MP0000249_abnormal_blood_vessel0.87148022
115MP0004510_myositis0.85501151
116MP0001663_abnormal_digestive_system0.85217787
117MP0000569_abnormal_digit_pigmentation0.83013310
118MP0002332_abnormal_exercise_endurance0.82909047
119MP0002006_tumorigenesis0.82101915
120MP0004036_abnormal_muscle_relaxation0.82024175
121MP0002060_abnormal_skin_morphology0.81733757
122MP0004808_abnormal_hematopoietic_stem0.80195382
123MP0001873_stomach_inflammation0.80186859
124MP0005275_abnormal_skin_tensile0.79593381
125MP0001756_abnormal_urination0.78105296
126MP0009763_increased_sensitivity_to0.77934091
127MP0002136_abnormal_kidney_physiology0.76965212
128MP0002972_abnormal_cardiac_muscle0.76122301
129MP0008004_abnormal_stomach_pH0.75679235
130MP0003795_abnormal_bone_structure0.74623421
131MP0000703_abnormal_thymus_morphology0.74100832
132MP0003656_abnormal_erythrocyte_physiolo0.72511081
133MP0010352_gastrointestinal_tract_polyps0.72451264
134MP0003279_aneurysm0.70992741
135MP0000371_diluted_coat_color0.70601120
136MP0003868_abnormal_feces_composition0.70527438
137MP0003950_abnormal_plasma_membrane0.70294440
138MP0010630_abnormal_cardiac_muscle0.69962491
139MP0000015_abnormal_ear_pigmentation0.69797338
140MP0009765_abnormal_xenobiotic_induced0.69475028
141MP0005165_increased_susceptibility_to0.68864289
142MP0002933_joint_inflammation0.68662532
143MP0001849_ear_inflammation0.68570914
144MP0001764_abnormal_homeostasis0.68124448
145MP0001845_abnormal_inflammatory_respons0.68092166
146MP0003329_amyloid_beta_deposits0.67314981
147MP0009642_abnormal_blood_homeostasis0.67221561
148MP0008874_decreased_physiological_sensi0.66810496
149MP0005385_cardiovascular_system_phenoty0.64925644
150MP0001544_abnormal_cardiovascular_syste0.64925644
151MP0009780_abnormal_chondrocyte_physiolo0.64697119
152MP0001915_intracranial_hemorrhage0.64362754
153MP0002168_other_aberrant_phenotype0.62982164
154MP0005375_adipose_tissue_phenotype0.61096558
155MP0005076_abnormal_cell_differentiation0.59989703
156MP0005330_cardiomyopathy0.59340056

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.32069409
2Deep venous thrombosis (HP:0002625)5.28980493
3Complement deficiency (HP:0004431)5.26529755
4Abnormality of macrophages (HP:0004311)5.25641469
5Recurrent abscess formation (HP:0002722)5.24191950
6Orchitis (HP:0100796)5.11561288
7Myositis (HP:0100614)5.09350874
8Retrobulbar optic neuritis (HP:0100654)4.86159250
9Optic neuritis (HP:0100653)4.86159250
10Systemic lupus erythematosus (HP:0002725)4.83087579
11Stomatitis (HP:0010280)4.58053157
12Abnormality of liposaccharide metabolism (HP:0010968)4.47101311
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.47101311
14Abnormality of glycolipid metabolism (HP:0010969)4.47101311
15Xanthomatosis (HP:0000991)4.28508471
16Intrahepatic cholestasis (HP:0001406)4.03922401
17Glomerulonephritis (HP:0000099)3.96506022
18Abnormality of monocarboxylic acid metabolism (HP:0010996)3.94072350
19Elevated erythrocyte sedimentation rate (HP:0003565)3.86665469
20Amelogenesis imperfecta (HP:0000705)3.85089195
21Abnormality of complement system (HP:0005339)3.70631284
22Keratoconjunctivitis sicca (HP:0001097)3.62173023
23Mediastinal lymphadenopathy (HP:0100721)3.58444103
24Recurrent fungal infections (HP:0002841)3.55212319
25Recurrent skin infections (HP:0001581)3.45256475
26Hypobetalipoproteinemia (HP:0003563)3.36893233
27Keratoconjunctivitis (HP:0001096)3.34244754
28Abnormality of aromatic amino acid family metabolism (HP:0004338)3.33726377
29Gastrointestinal infarctions (HP:0005244)3.33577649
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.27824241
31Right ventricular cardiomyopathy (HP:0011663)3.25751372
32Recurrent gram-negative bacterial infections (HP:0005420)3.23654790
33Chronic obstructive pulmonary disease (HP:0006510)3.19511334
34Obstructive lung disease (HP:0006536)3.19511334
35Abnormality of glutamine family amino acid metabolism (HP:0010902)3.18810787
36Esophageal varix (HP:0002040)3.17053220
37Prolonged partial thromboplastin time (HP:0003645)3.15508386
38Vasculitis (HP:0002633)3.09521482
39Meningitis (HP:0001287)3.09113206
40Recurrent cutaneous fungal infections (HP:0011370)3.08416860
41Chronic mucocutaneous candidiasis (HP:0002728)3.08416860
42Hyperlipoproteinemia (HP:0010980)3.06656123
43Loss of speech (HP:0002371)3.06650743
44Pulmonary infiltrates (HP:0002113)3.06484027
45Polycythemia (HP:0001901)3.04959172
46Gingivitis (HP:0000230)3.04836361
47Hemoptysis (HP:0002105)3.03957889
48Urticaria (HP:0001025)3.01791159
49Nephritis (HP:0000123)3.00833276
50Encephalitis (HP:0002383)3.00699793
51Myocardial infarction (HP:0001658)2.95835300
52Abnormality of the common coagulation pathway (HP:0010990)2.92630768
53Hypolipoproteinemia (HP:0010981)2.90692051
54T lymphocytopenia (HP:0005403)2.90526658
55Hypoalphalipoproteinemia (HP:0003233)2.89046099
56Abnormality of T cell number (HP:0011839)2.86049951
57Hematochezia (HP:0002573)2.81227121
58Cerebral aneurysm (HP:0004944)2.78137907
59Arterial thrombosis (HP:0004420)2.77632622
60Vacuolated lymphocytes (HP:0001922)2.76260360
61Joint hemorrhage (HP:0005261)2.76066324
62Hypercholesterolemia (HP:0003124)2.72458174
63Chest pain (HP:0100749)2.71534513
64Hyperammonemia (HP:0001987)2.68756363
65Abnormality of sulfur amino acid metabolism (HP:0004339)2.68275460
66Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.65621050
67Increased neuronal autofluorescent lipopigment (HP:0002074)2.65447766
68Epidermoid cyst (HP:0200040)2.63858642
69Episodic fever (HP:0001954)2.63630552
70Axonal loss (HP:0003447)2.63428715
71Fat malabsorption (HP:0002630)2.57282770
72Ketosis (HP:0001946)2.55053696
73Peritonitis (HP:0002586)2.54846342
74Amyloidosis (HP:0011034)2.53591354
75Leukocytosis (HP:0001974)2.51466197
76Aortic aneurysm (HP:0004942)2.51255258
77Increased IgE level (HP:0003212)2.51080426
78Recurrent viral infections (HP:0004429)2.48108499
79Prolonged bleeding time (HP:0003010)2.47056204
80Epistaxis (HP:0000421)2.45653886
81Hemorrhage of the eye (HP:0011885)2.43382897
82Pulmonary embolism (HP:0002204)2.42651765
83Anorexia (HP:0002039)2.42337855
84Gangrene (HP:0100758)2.40995213
85Disinhibition (HP:0000734)2.39131050
86Cellulitis (HP:0100658)2.34540934
87Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34124878
88Abnormality of fatty-acid metabolism (HP:0004359)2.33775126
89Eczematoid dermatitis (HP:0000976)2.31969418
90Spontaneous hematomas (HP:0007420)2.30378520
91Mitral stenosis (HP:0001718)2.29336696
92Pustule (HP:0200039)2.27804551
93Retinal atrophy (HP:0001105)2.27340870
94Hypoglycemic coma (HP:0001325)2.26447717
95Atrophic scars (HP:0001075)2.26147858
96Petechiae (HP:0000967)2.25920567
97Vascular calcification (HP:0004934)2.25361091
98Hyperglycinuria (HP:0003108)2.24118887
99Abnormality of purine metabolism (HP:0004352)2.23022191
100Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.22863494
101Urethral obstruction (HP:0000796)2.21801909
102Onycholysis (HP:0001806)2.21790332
103Disproportionate tall stature (HP:0001519)2.21050047
104Milia (HP:0001056)2.20805895
105Skin nodule (HP:0200036)2.20459301
106Ketoacidosis (HP:0001993)2.20377395
107Abnormality of T cells (HP:0002843)2.20235920
108Autoimmune thrombocytopenia (HP:0001973)2.19793512
109Conjugated hyperbilirubinemia (HP:0002908)2.19445124
110Osteomyelitis (HP:0002754)2.18606856
111Abnormality of the pleura (HP:0002103)2.16903344
112Cardiovascular calcification (HP:0011915)2.15890216
113Increased IgM level (HP:0003496)2.15772376
114Gout (HP:0001997)2.14347839
115Malnutrition (HP:0004395)2.12182341
116Ventricular tachycardia (HP:0004756)2.07667968
117Sensorimotor neuropathy (HP:0007141)2.07321531
118Urinary glycosaminoglycan excretion (HP:0003541)2.07098321
119Mucopolysacchariduria (HP:0008155)2.07098321
120Cholelithiasis (HP:0001081)2.06449734
121Autoimmune hemolytic anemia (HP:0001890)2.05675349
122Increased serum ferritin (HP:0003281)2.05378470
123Aneurysm (HP:0002617)2.04231768
124Abnormality of the intrinsic pathway (HP:0010989)2.01796646
125Hydroxyprolinuria (HP:0003080)2.00727084
126Abnormality of proline metabolism (HP:0010907)2.00727084
127Glomerulopathy (HP:0100820)2.00691021
128Abnormality of polysaccharide metabolism (HP:0011012)2.00501226
129Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00501226
130Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00501226
131Abnormality of nucleobase metabolism (HP:0010932)2.00081859
132Abnormality of the pericardium (HP:0001697)1.99955547
133Polyneuropathy (HP:0001271)1.99719555
134Arterial tortuosity (HP:0005116)1.99037854
135Vertigo (HP:0002321)1.98748953
136Interstitial pulmonary disease (HP:0006530)1.98579705
137Hyperglycinemia (HP:0002154)1.97902560
138Abnormality of the endocardium (HP:0004306)1.97317455
139Abnormality of glycine metabolism (HP:0010895)1.95573288
140Abnormality of serine family amino acid metabolism (HP:0010894)1.95573288
141Striae distensae (HP:0001065)1.95444016
142Increased CSF protein (HP:0002922)1.95029643
143Abnormality of methionine metabolism (HP:0010901)1.94292836
144Increased cerebral lipofuscin (HP:0011813)1.93632921
145Purpura (HP:0000979)1.93342993
146Abnormal gallbladder morphology (HP:0012437)1.93256641
147Cholecystitis (HP:0001082)1.91899119
148Abnormal gallbladder physiology (HP:0012438)1.91899119
149Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90756490
150Keratitis (HP:0000491)1.90169036
151Abnormality of iron homeostasis (HP:0011031)1.89564652
152Hepatosplenomegaly (HP:0001433)1.89349712
153Inflammation of the large intestine (HP:0002037)1.88271175
154Impaired platelet aggregation (HP:0003540)1.88069946
155Abnormal platelet function (HP:0011869)1.88069946
156Abnormality of T cell physiology (HP:0011840)1.86837995
157Reticulocytosis (HP:0001923)1.86635149
158Granulocytopenia (HP:0001913)1.86473473
159Gingival bleeding (HP:0000225)1.85857883
160Hypergammaglobulinemia (HP:0010702)1.85442984
161Vascular tortuosity (HP:0004948)1.85077393
162Mitral valve prolapse (HP:0001634)1.84886092
163Peripheral demyelination (HP:0011096)1.84663026
164Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84284687
165Abnormality of the peritoneum (HP:0002585)1.83908669
166Hyporeflexia of lower limbs (HP:0002600)1.83825518
167Eosinophilia (HP:0001880)1.83416007
168Acne (HP:0001061)1.83244374
169Mutism (HP:0002300)1.82479756
170Dysostosis multiplex (HP:0000943)1.80513552
171Premature loss of primary teeth (HP:0006323)1.79047569
172Cheilitis (HP:0100825)1.78742880
173Neurofibrillary tangles (HP:0002185)1.78707368
174Recurrent pneumonia (HP:0006532)1.78658581
175Spondylolisthesis (HP:0003302)1.78079847
176Hyperglycemia (HP:0003074)1.77475641
177Stroke (HP:0001297)1.76626479
178Hepatocellular carcinoma (HP:0001402)1.76467594
179Focal segmental glomerulosclerosis (HP:0000097)1.75471418
180Metabolic acidosis (HP:0001942)1.74289693
181Aortic dissection (HP:0002647)1.74231526
182Hyperbilirubinemia (HP:0002904)1.74020135
183Asymmetric septal hypertrophy (HP:0001670)1.73549777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR23.96954262
2ERN13.46934262
3BLK3.40762411
4RIPK13.18598924
5TIE12.37997980
6IRAK32.23555766
7MAP3K32.17481147
8FGFR42.15749242
9SIK12.12519875
10EPHB12.10530527
11MAPK152.05199975
12KDR1.92985276
13FES1.85184248
14LATS11.81798794
15TRIB31.80603062
16AKT31.79482067
17TXK1.77864122
18PTK61.75281650
19CAMK1D1.68248414
20DAPK21.66177836
21PDK21.56340273
22PRPF4B1.53792169
23PKN21.53748576
24BMPR21.49456084
25MAP2K31.49001698
26SYK1.45651578
27CAMK1G1.44608878
28TTN1.40256847
29TNK21.40099852
30PDGFRA1.38938398
31TBK11.38879525
32TRPM71.36258585
33PTK21.34709747
34IRAK11.33349942
35PAK41.28245335
36BTK1.27977598
37YES11.23853637
38ACVR1B1.21787557
39TAOK11.21232963
40PTK2B1.20810475
41LYN1.20404154
42TYK21.19674032
43STK101.19444684
44IKBKB1.17976637
45CSK1.17201284
46KIT1.13073477
47SIK31.11387263
48MAPK121.06472704
49SGK31.06213651
50FRK1.05523924
51IRAK21.05270535
52TAOK21.04884290
53INSRR0.99492239
54JAK10.99479698
55CDC42BPA0.98504989
56MARK30.98238599
57LCK0.97931506
58MATK0.95677623
59BCKDK0.94539107
60FGFR30.94426225
61MYLK0.93847611
62FER0.92591587
63EPHA20.92096298
64DDR20.89654650
65CASK0.87634271
66MST1R0.86797003
67DMPK0.85784045
68PDGFRB0.83995953
69SIK20.83650740
70JAK20.82350170
71MAP3K140.82345082
72MAP3K50.82271997
73ICK0.81773132
74TEC0.81528038
75STK240.81476155
76MAP3K70.81253799
77MAPK70.79932129
78ZAP700.79872415
79RIPK40.79777301
80PDPK10.79398327
81MAP3K130.78704911
82ITK0.77469378
83ERBB20.76145293
84RET0.76092351
85MAP3K10.75914124
86EPHB20.75843795
87FGFR20.75231216
88MOS0.72673735
89CAMKK20.71510653
90MAP3K20.71473838
91PRKAA20.71196110
92MARK20.69761331
93CSF1R0.69593363
94STK30.69230445
95IRAK40.68617206
96TAOK30.68147279
97EPHA30.67952535
98SGK20.67923349
99PIK3CG0.67826315
100IKBKE0.67423376
101MAP2K40.66356353
102PIK3CA0.65029282
103PRKD20.63323006
104MET0.62393643
105KSR20.62341817
106EGFR0.61938432
107LMTK20.61626424
108NLK0.61260882
109PRKD10.60278792
110CHUK0.59533289
111GRK60.59050500
112HCK0.58106302
113MAP3K110.57318910
114WNK10.57259688
115GSK3A0.56125927
116STK380.55142657
117KSR10.54675827
118MAP2K60.54297981
119IGF1R0.54282228
120PRKG20.53543407
121MAP3K100.53154569
122FGR0.52693101
123NEK90.51346928
124PRKCH0.51144151
125MAP3K60.51060283
126CDK60.49792144
127FYN0.49242217
128GRK70.48286583
129PDK10.47926969
130ERBB40.46878834
131MAP4K10.46864219
132LRRK20.45783718
133BMX0.45290318
134MTOR0.44833766
135PAK20.44444451
136PDK30.44046522
137PDK40.44046522
138JAK30.43578393
139ADRBK20.42816194
140PRKCQ0.41825234
141HIPK20.39314313
142MAP3K80.39194934
143ABL10.38104739
144CLK10.35237662
145MAPKAPK20.31266968
146PIM10.30939034
147MELK0.29666711

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.01489093
2Nitrogen metabolism_Homo sapiens_hsa009102.87812061
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81237396
4Staphylococcus aureus infection_Homo sapiens_hsa051502.77956846
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.66881185
6Complement and coagulation cascades_Homo sapiens_hsa046102.55258774
7Arginine biosynthesis_Homo sapiens_hsa002202.48674009
8Graft-versus-host disease_Homo sapiens_hsa053322.18696050
9Caffeine metabolism_Homo sapiens_hsa002322.14035668
10Allograft rejection_Homo sapiens_hsa053302.10573054
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.06713504
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.05174716
13Malaria_Homo sapiens_hsa051442.04609316
14Fatty acid degradation_Homo sapiens_hsa000712.00395820
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.90800152
16Autoimmune thyroid disease_Homo sapiens_hsa053201.82249110
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81505521
18Tryptophan metabolism_Homo sapiens_hsa003801.79921427
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.78464146
20B cell receptor signaling pathway_Homo sapiens_hsa046621.77351084
21Legionellosis_Homo sapiens_hsa051341.76851209
22PPAR signaling pathway_Homo sapiens_hsa033201.74231356
23TNF signaling pathway_Homo sapiens_hsa046681.71991555
24Rheumatoid arthritis_Homo sapiens_hsa053231.70688601
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68601057
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.68192120
27Hematopoietic cell lineage_Homo sapiens_hsa046401.60823191
28Measles_Homo sapiens_hsa051621.58085919
29Bile secretion_Homo sapiens_hsa049761.57953984
30Type I diabetes mellitus_Homo sapiens_hsa049401.55535710
31Influenza A_Homo sapiens_hsa051641.55137009
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.54757758
33Chemokine signaling pathway_Homo sapiens_hsa040621.49021503
34Phagosome_Homo sapiens_hsa041451.46106080
35Antigen processing and presentation_Homo sapiens_hsa046121.44938765
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.44611199
37Asthma_Homo sapiens_hsa053101.44370669
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44143013
39Histidine metabolism_Homo sapiens_hsa003401.40324812
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36219679
41Fat digestion and absorption_Homo sapiens_hsa049751.34813847
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33937193
43Starch and sucrose metabolism_Homo sapiens_hsa005001.33855847
44Fatty acid metabolism_Homo sapiens_hsa012121.33604591
45Chemical carcinogenesis_Homo sapiens_hsa052041.30808675
46T cell receptor signaling pathway_Homo sapiens_hsa046601.30180682
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26880973
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26589917
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.26508253
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.26327241
51Acute myeloid leukemia_Homo sapiens_hsa052211.26192614
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26138611
53Salmonella infection_Homo sapiens_hsa051321.25117806
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22078104
55Propanoate metabolism_Homo sapiens_hsa006401.19813580
56Viral myocarditis_Homo sapiens_hsa054161.19692852
57ABC transporters_Homo sapiens_hsa020101.19554253
58Herpes simplex infection_Homo sapiens_hsa051681.18787436
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18434772
60Hepatitis C_Homo sapiens_hsa051601.18319474
61Peroxisome_Homo sapiens_hsa041461.17659059
62Primary immunodeficiency_Homo sapiens_hsa053401.15152461
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13966384
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13593096
65Hepatitis B_Homo sapiens_hsa051611.09615266
66Steroid hormone biosynthesis_Homo sapiens_hsa001401.09545157
67Pyruvate metabolism_Homo sapiens_hsa006201.09119117
68Phenylalanine metabolism_Homo sapiens_hsa003601.06133190
69Vitamin digestion and absorption_Homo sapiens_hsa049771.05657365
70beta-Alanine metabolism_Homo sapiens_hsa004101.04866516
71Lysine degradation_Homo sapiens_hsa003101.03458859
72Butanoate metabolism_Homo sapiens_hsa006501.03136944
73Platelet activation_Homo sapiens_hsa046110.96367592
74Shigellosis_Homo sapiens_hsa051310.94310749
75Retinol metabolism_Homo sapiens_hsa008300.91795192
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91185616
77Carbon metabolism_Homo sapiens_hsa012000.86783977
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86350126
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85071108
80VEGF signaling pathway_Homo sapiens_hsa043700.83700643
81Insulin resistance_Homo sapiens_hsa049310.83620654
82Amoebiasis_Homo sapiens_hsa051460.83148668
83Apoptosis_Homo sapiens_hsa042100.82217292
84Dorso-ventral axis formation_Homo sapiens_hsa043200.81707715
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80917032
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79193777
87Prolactin signaling pathway_Homo sapiens_hsa049170.78115000
88Renal cell carcinoma_Homo sapiens_hsa052110.77414300
89Sulfur metabolism_Homo sapiens_hsa009200.76844514
90Adherens junction_Homo sapiens_hsa045200.75862992
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75644891
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.73604672
93Chronic myeloid leukemia_Homo sapiens_hsa052200.73380790
94Tyrosine metabolism_Homo sapiens_hsa003500.72929051
95Glycerolipid metabolism_Homo sapiens_hsa005610.72836210
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.70342755
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.69671046
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69362212
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.68748587
100Non-small cell lung cancer_Homo sapiens_hsa052230.68360224
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67059224
102Lysosome_Homo sapiens_hsa041420.66944709
103Osteoclast differentiation_Homo sapiens_hsa043800.65812651
104Endocytosis_Homo sapiens_hsa041440.65787397
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.64387111
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63761925
107Galactose metabolism_Homo sapiens_hsa000520.61324082
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60622346
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.60582971
110Selenocompound metabolism_Homo sapiens_hsa004500.60341210
111Biosynthesis of amino acids_Homo sapiens_hsa012300.59851581
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59654556
113Pertussis_Homo sapiens_hsa051330.58528695
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.58424551
115Leishmaniasis_Homo sapiens_hsa051400.58312312
116HIF-1 signaling pathway_Homo sapiens_hsa040660.57047269
117FoxO signaling pathway_Homo sapiens_hsa040680.56869453
118Prion diseases_Homo sapiens_hsa050200.56547932
119Mineral absorption_Homo sapiens_hsa049780.54602836
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53954142
121ECM-receptor interaction_Homo sapiens_hsa045120.52048025
122Focal adhesion_Homo sapiens_hsa045100.51978881
123Bladder cancer_Homo sapiens_hsa052190.51634415
124Toxoplasmosis_Homo sapiens_hsa051450.50713448
125Renin-angiotensin system_Homo sapiens_hsa046140.49220940
126Type II diabetes mellitus_Homo sapiens_hsa049300.48533094
127Other glycan degradation_Homo sapiens_hsa005110.47971274
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46884109
129GnRH signaling pathway_Homo sapiens_hsa049120.46491677
130Choline metabolism in cancer_Homo sapiens_hsa052310.44056855
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43767611
132Fatty acid elongation_Homo sapiens_hsa000620.42760966
133Epstein-Barr virus infection_Homo sapiens_hsa051690.41366042
134Sphingolipid metabolism_Homo sapiens_hsa006000.41097660
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40105047
136* Notch signaling pathway_Homo sapiens_hsa043300.40005944
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39902301
138Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39382412
139Folate biosynthesis_Homo sapiens_hsa007900.39337806
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39267363
141Endometrial cancer_Homo sapiens_hsa052130.39209937
142Dilated cardiomyopathy_Homo sapiens_hsa054140.39205823
143Fatty acid biosynthesis_Homo sapiens_hsa000610.38396969
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37767385
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36803796
146HTLV-I infection_Homo sapiens_hsa051660.36787444
147African trypanosomiasis_Homo sapiens_hsa051430.36766971
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36267683
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35746061
150Viral carcinogenesis_Homo sapiens_hsa052030.35450445
151Collecting duct acid secretion_Homo sapiens_hsa049660.35286688
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34163806
153Arginine and proline metabolism_Homo sapiens_hsa003300.34002848
154Fructose and mannose metabolism_Homo sapiens_hsa000510.33803192
155Prostate cancer_Homo sapiens_hsa052150.33441822
156Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33141051
157Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32840391
158Proteoglycans in cancer_Homo sapiens_hsa052050.32737276
159Central carbon metabolism in cancer_Homo sapiens_hsa052300.32718563
160Cysteine and methionine metabolism_Homo sapiens_hsa002700.32093263
161Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31738314
162Pentose phosphate pathway_Homo sapiens_hsa000300.30924303
163Glucagon signaling pathway_Homo sapiens_hsa049220.30028043
164Rap1 signaling pathway_Homo sapiens_hsa040150.29881913
165Tuberculosis_Homo sapiens_hsa051520.28556891
166Insulin signaling pathway_Homo sapiens_hsa049100.27394106
167Pancreatic cancer_Homo sapiens_hsa052120.27282955
168Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27190169
169Protein digestion and absorption_Homo sapiens_hsa049740.26884681
170Small cell lung cancer_Homo sapiens_hsa052220.26719432

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