

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle maturation (GO:0016188) | 5.67911654 |
| 2 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 5.66365279 |
| 3 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.61595970 |
| 4 | locomotory exploration behavior (GO:0035641) | 5.52330186 |
| 5 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.17957813 |
| 6 | vocalization behavior (GO:0071625) | 5.07456571 |
| 7 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.03631451 |
| 8 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.67984903 |
| 9 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.61172524 |
| 10 | glutamate secretion (GO:0014047) | 4.40524946 |
| 11 | synaptic vesicle exocytosis (GO:0016079) | 4.27662129 |
| 12 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.27643292 |
| 13 | exploration behavior (GO:0035640) | 4.18366797 |
| 14 | dendritic spine morphogenesis (GO:0060997) | 4.17796245 |
| 15 | regulation of synapse structural plasticity (GO:0051823) | 4.12101672 |
| 16 | protein localization to synapse (GO:0035418) | 4.08243779 |
| 17 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.05403640 |
| 18 | layer formation in cerebral cortex (GO:0021819) | 4.05334891 |
| 19 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.02494743 |
| 20 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.88261974 |
| 21 | proline transport (GO:0015824) | 3.79113227 |
| 22 | positive regulation of synapse maturation (GO:0090129) | 3.75223320 |
| 23 | regulation of synaptic vesicle transport (GO:1902803) | 3.71907596 |
| 24 | synaptic transmission, glutamatergic (GO:0035249) | 3.70951326 |
| 25 | neurotransmitter secretion (GO:0007269) | 3.60626445 |
| 26 | protein heterotrimerization (GO:0070208) | 3.59664897 |
| 27 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.43518581 |
| 28 | dendritic spine organization (GO:0097061) | 3.40129321 |
| 29 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.39940314 |
| 30 | cell migration in hindbrain (GO:0021535) | 3.38260243 |
| 31 | glutamate receptor signaling pathway (GO:0007215) | 3.36887663 |
| 32 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.36637211 |
| 33 | neuromuscular process controlling balance (GO:0050885) | 3.32266036 |
| 34 | establishment of nucleus localization (GO:0040023) | 3.28347165 |
| 35 | neuron cell-cell adhesion (GO:0007158) | 3.28220728 |
| 36 | dendrite morphogenesis (GO:0048813) | 3.28194698 |
| 37 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.27032881 |
| 38 | urinary tract smooth muscle contraction (GO:0014848) | 3.25955922 |
| 39 | long-term memory (GO:0007616) | 3.25023112 |
| 40 | axonal fasciculation (GO:0007413) | 3.24993595 |
| 41 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.24728279 |
| 42 | kidney mesenchyme development (GO:0072074) | 3.24547712 |
| 43 | synaptic vesicle endocytosis (GO:0048488) | 3.23393284 |
| 44 | positive regulation of membrane potential (GO:0045838) | 3.22542097 |
| 45 | regulation of synaptic plasticity (GO:0048167) | 3.21331580 |
| 46 | neuron-neuron synaptic transmission (GO:0007270) | 3.19537139 |
| 47 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.18111515 |
| 48 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.15094730 |
| 49 | innervation (GO:0060384) | 3.14930891 |
| 50 | response to pheromone (GO:0019236) | 3.14659254 |
| 51 | cell communication by electrical coupling (GO:0010644) | 3.14274959 |
| 52 | positive regulation of fibroblast migration (GO:0010763) | 3.12231616 |
| 53 | metanephric mesenchyme development (GO:0072075) | 3.11215794 |
| 54 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.11005120 |
| 55 | regulation of postsynaptic membrane potential (GO:0060078) | 3.10270951 |
| 56 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.08171991 |
| 57 | cerebellar granule cell differentiation (GO:0021707) | 3.06275316 |
| 58 | neuron recognition (GO:0008038) | 3.05829859 |
| 59 | neuronal ion channel clustering (GO:0045161) | 3.05779898 |
| 60 | postsynaptic membrane organization (GO:0001941) | 3.03036778 |
| 61 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.02686107 |
| 62 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.01693407 |
| 63 | calcium ion-dependent exocytosis (GO:0017156) | 3.01405857 |
| 64 | neuronal action potential propagation (GO:0019227) | 2.99514248 |
| 65 | sodium ion export (GO:0071436) | 2.99436546 |
| 66 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.98660222 |
| 67 | cranial nerve morphogenesis (GO:0021602) | 2.98089335 |
| 68 | regulation of synapse maturation (GO:0090128) | 2.97641165 |
| 69 | negative regulation of catenin import into nucleus (GO:0035414) | 2.97529299 |
| 70 | auditory behavior (GO:0031223) | 2.96818341 |
| 71 | regulation of neurotransmitter secretion (GO:0046928) | 2.95927048 |
| 72 | positive regulation of neurotransmitter transport (GO:0051590) | 2.95433006 |
| 73 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 2.94580095 |
| 74 | activation of protein kinase A activity (GO:0034199) | 2.93365214 |
| 75 | cellular potassium ion homeostasis (GO:0030007) | 2.93182727 |
| 76 | microtubule severing (GO:0051013) | 2.92450781 |
| 77 | gamma-aminobutyric acid transport (GO:0015812) | 2.92352069 |
| 78 | neuromuscular synaptic transmission (GO:0007274) | 2.91176575 |
| 79 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.89694167 |
| 80 | glycine transport (GO:0015816) | 2.89683407 |
| 81 | response to auditory stimulus (GO:0010996) | 2.89657891 |
| 82 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.87739653 |
| 83 | regulation of respiratory system process (GO:0044065) | 2.81368711 |
| 84 | behavioral response to nicotine (GO:0035095) | 2.80248564 |
| 85 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.77800457 |
| 86 | regulation of axon extension involved in axon guidance (GO:0048841) | 2.75759399 |
| 87 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.75308629 |
| 88 | establishment or maintenance of monopolar cell polarity (GO:0061339) | 2.73106204 |
| 89 | establishment of monopolar cell polarity (GO:0061162) | 2.73106204 |
| 90 | bone trabecula formation (GO:0060346) | 2.72893272 |
| 91 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.72495424 |
| 92 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.71748240 |
| 93 | neurotransmitter transport (GO:0006836) | 2.71439863 |
| 94 | acrosome reaction (GO:0007340) | 2.71235883 |
| 95 | regulation of neurotransmitter transport (GO:0051588) | 2.70746560 |
| 96 | neuromuscular process (GO:0050905) | 2.68485113 |
| 97 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 2.66867414 |
| 98 | membrane depolarization during action potential (GO:0086010) | 2.66578632 |
| 99 | axon extension involved in axon guidance (GO:0048846) | 2.66446719 |
| 100 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 2.66446719 |
| 101 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.65698299 |
| 102 | learning (GO:0007612) | 2.64611299 |
| 103 | prepulse inhibition (GO:0060134) | 2.64292417 |
| 104 | long-term synaptic potentiation (GO:0060291) | 2.63862552 |
| 105 | cerebellar Purkinje cell layer development (GO:0021680) | 2.63100330 |
| 106 | membrane depolarization (GO:0051899) | 2.63094524 |
| 107 | response to acidic pH (GO:0010447) | 2.61782917 |
| 108 | long term synaptic depression (GO:0060292) | 2.61666577 |
| 109 | vesicle transport along microtubule (GO:0047496) | 2.61043474 |
| 110 | regulation of vesicle fusion (GO:0031338) | 2.59384951 |
| 111 | axon extension (GO:0048675) | 2.59137654 |
| 112 | regulation of synaptic transmission (GO:0050804) | 2.58657640 |
| 113 | positive regulation of synaptic transmission (GO:0050806) | 2.57729317 |
| 114 | establishment of apical/basal cell polarity (GO:0035089) | 2.57705731 |
| 115 | transmission of nerve impulse (GO:0019226) | 2.57626855 |
| 116 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.56647394 |
| 117 | positive regulation of synapse assembly (GO:0051965) | 2.55774325 |
| 118 | positive regulation of dendritic spine development (GO:0060999) | 2.54265412 |
| 119 | presynaptic membrane assembly (GO:0097105) | 2.53611230 |
| 120 | regulation of dendritic spine development (GO:0060998) | 2.52570483 |
| 121 | regulation of axon guidance (GO:1902667) | 2.52414697 |
| 122 | cochlea morphogenesis (GO:0090103) | 2.51165188 |
| 123 | membrane hyperpolarization (GO:0060081) | 2.50563294 |
| 124 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.49774032 |
| 125 | daunorubicin metabolic process (GO:0044597) | 2.49722806 |
| 126 | polyketide metabolic process (GO:0030638) | 2.49722806 |
| 127 | doxorubicin metabolic process (GO:0044598) | 2.49722806 |
| 128 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 2.49340536 |
| 129 | tooth mineralization (GO:0034505) | 2.47073189 |
| 130 | dermatan sulfate metabolic process (GO:0030205) | 2.46278986 |
| 131 | skeletal muscle organ development (GO:0060538) | 2.45563976 |
| 132 | camera-type eye morphogenesis (GO:0048593) | 2.45334656 |
| 133 | dermatan sulfate biosynthetic process (GO:0030208) | 2.44209223 |
| 134 | protein polyglutamylation (GO:0018095) | 2.43879115 |
| 135 | outer ear morphogenesis (GO:0042473) | 2.40904495 |
| 136 | regulation of respiratory gaseous exchange (GO:0043576) | 2.40822780 |
| 137 | positive regulation of axon extension (GO:0045773) | 2.40569295 |
| 138 | presynaptic membrane organization (GO:0097090) | 2.40229379 |
| 139 | cell-cell junction maintenance (GO:0045217) | 2.37806137 |
| 140 | sperm motility (GO:0030317) | 2.35949378 |
| 141 | neuromuscular process controlling posture (GO:0050884) | 2.35658925 |
| 142 | response to gravity (GO:0009629) | 2.35123005 |
| 143 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.32087450 |
| 144 | neuron projection extension (GO:1990138) | 2.31476228 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.56085878 |
| 2 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.47814601 |
| 3 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.98854631 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.92233461 |
| 5 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.90019341 |
| 6 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.90019341 |
| 7 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.88517367 |
| 8 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.77959597 |
| 9 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.71566381 |
| 10 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.65840772 |
| 11 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.64655034 |
| 12 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.59080331 |
| 13 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.51654306 |
| 14 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.47920795 |
| 15 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.46167658 |
| 16 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.40706758 |
| 17 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.40703946 |
| 18 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.36598988 |
| 19 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.35512017 |
| 20 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.31818076 |
| 21 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.29861110 |
| 22 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.26850296 |
| 23 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.22381592 |
| 24 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.14742794 |
| 25 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.13931794 |
| 26 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.05940300 |
| 27 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.98578572 |
| 28 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.90693283 |
| 29 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.90229771 |
| 30 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.85601496 |
| 31 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.81704773 |
| 32 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.79531564 |
| 33 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.70299324 |
| 34 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.68139869 |
| 35 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.67393755 |
| 36 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.60466073 |
| 37 | KDM2B_26808549_Chip-Seq_K562_Human | 1.60272090 |
| 38 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.59406598 |
| 39 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.58017826 |
| 40 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.52443786 |
| 41 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.48607069 |
| 42 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.43560643 |
| 43 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.41270146 |
| 44 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.39845628 |
| 45 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.39551192 |
| 46 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.38165191 |
| 47 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.35406967 |
| 48 | * SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.32959804 |
| 49 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.32790111 |
| 50 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.32781174 |
| 51 | P68_20966046_ChIP-Seq_HELA_Human | 1.32016751 |
| 52 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.30616427 |
| 53 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.30454093 |
| 54 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.29509202 |
| 55 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.28883940 |
| 56 | AR_19668381_ChIP-Seq_PC3_Human | 1.28423166 |
| 57 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.27787166 |
| 58 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.27117338 |
| 59 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.26883896 |
| 60 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.24359860 |
| 61 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.24207508 |
| 62 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.22477921 |
| 63 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.21980522 |
| 64 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.20883731 |
| 65 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.18666937 |
| 66 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.17985034 |
| 67 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.17827153 |
| 68 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.16811273 |
| 69 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.16686621 |
| 70 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.16269817 |
| 71 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.11583061 |
| 72 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.10785978 |
| 73 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.09882869 |
| 74 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.09846449 |
| 75 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.08478256 |
| 76 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.08141172 |
| 77 | RXR_22108803_ChIP-Seq_LS180_Human | 1.06958299 |
| 78 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.06453360 |
| 79 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.05246526 |
| 80 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.05159170 |
| 81 | * OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.02166728 |
| 82 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.01530362 |
| 83 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.00567347 |
| 84 | * KLF4_19829295_ChIP-Seq_ESCs_Human | 1.00548110 |
| 85 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.00530011 |
| 86 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.99332186 |
| 87 | TP53_16413492_ChIP-PET_HCT116_Human | 0.99034382 |
| 88 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.98495373 |
| 89 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.98345672 |
| 90 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.98193702 |
| 91 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.97381647 |
| 92 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.97080357 |
| 93 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.96534915 |
| 94 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.96409195 |
| 95 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.96182155 |
| 96 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.95962752 |
| 97 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.95254265 |
| 98 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.95116681 |
| 99 | STAT3_23295773_ChIP-Seq_U87_Human | 0.94275464 |
| 100 | * RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.94149185 |
| 101 | * ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.93921433 |
| 102 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 0.93050777 |
| 103 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.93004461 |
| 104 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.92820855 |
| 105 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.92567894 |
| 106 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.92468799 |
| 107 | AR_25329375_ChIP-Seq_VCAP_Human | 0.91763482 |
| 108 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.91518486 |
| 109 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.91349199 |
| 110 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.91232689 |
| 111 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.91232689 |
| 112 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.90801006 |
| 113 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.90580790 |
| 114 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.90379207 |
| 115 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.90376593 |
| 116 | * SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.89427149 |
| 117 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.89229808 |
| 118 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.88597341 |
| 119 | MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse | 0.85994140 |
| 120 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.85698158 |
| 121 | * E2F1_20622854_ChIP-Seq_HELA_Human | 0.85314446 |
| 122 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.85293925 |
| 123 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.85200992 |
| 124 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.84780019 |
| 125 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.84691920 |
| 126 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.84665040 |
| 127 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.84651141 |
| 128 | * TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.83998452 |
| 129 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.83663878 |
| 130 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.83651761 |
| 131 | SA1_27219007_Chip-Seq_Bcells_Human | 0.83560586 |
| 132 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.83478849 |
| 133 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.82678007 |
| 134 | * LXR_22292898_ChIP-Seq_THP-1_Human | 0.82598543 |
| 135 | * TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.82391371 |
| 136 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.81910548 |
| 137 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.81862992 |
| 138 | TCF4_23295773_ChIP-Seq_U87_Human | 0.80984136 |
| 139 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.80905956 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.49753049 |
| 2 | MP0003635_abnormal_synaptic_transmissio | 3.53190684 |
| 3 | MP0003880_abnormal_central_pattern | 3.20365116 |
| 4 | MP0004270_analgesia | 2.93649209 |
| 5 | MP0002063_abnormal_learning/memory/cond | 2.85755545 |
| 6 | MP0004858_abnormal_nervous_system | 2.66236570 |
| 7 | MP0009745_abnormal_behavioral_response | 2.62920266 |
| 8 | MP0005423_abnormal_somatic_nervous | 2.55581753 |
| 9 | MP0002064_seizures | 2.37012877 |
| 10 | MP0001968_abnormal_touch/_nociception | 2.33140326 |
| 11 | MP0009046_muscle_twitch | 2.33034769 |
| 12 | MP0002572_abnormal_emotion/affect_behav | 2.30519414 |
| 13 | MP0001486_abnormal_startle_reflex | 2.20423723 |
| 14 | MP0009780_abnormal_chondrocyte_physiolo | 2.12568534 |
| 15 | MP0002734_abnormal_mechanical_nocicepti | 2.09931126 |
| 16 | MP0001958_emphysema | 2.03411984 |
| 17 | MP0002735_abnormal_chemical_nociception | 1.88149479 |
| 18 | MP0003283_abnormal_digestive_organ | 1.87616942 |
| 19 | MP0003122_maternal_imprinting | 1.84116310 |
| 20 | MP0002272_abnormal_nervous_system | 1.83786002 |
| 21 | MP0002822_catalepsy | 1.82629876 |
| 22 | MP0005623_abnormal_meninges_morphology | 1.79417041 |
| 23 | MP0000778_abnormal_nervous_system | 1.77701569 |
| 24 | MP0002184_abnormal_innervation | 1.75983421 |
| 25 | MP0004811_abnormal_neuron_physiology | 1.74717264 |
| 26 | MP0003879_abnormal_hair_cell | 1.72849945 |
| 27 | MP0001501_abnormal_sleep_pattern | 1.71778963 |
| 28 | MP0002736_abnormal_nociception_after | 1.68221217 |
| 29 | MP0000569_abnormal_digit_pigmentation | 1.67865278 |
| 30 | MP0002733_abnormal_thermal_nociception | 1.61136928 |
| 31 | MP0001440_abnormal_grooming_behavior | 1.58614656 |
| 32 | MP0003787_abnormal_imprinting | 1.58526152 |
| 33 | MP0005670_abnormal_white_adipose | 1.56657169 |
| 34 | MP0002557_abnormal_social/conspecific_i | 1.55520647 |
| 35 | MP0005503_abnormal_tendon_morphology | 1.55487797 |
| 36 | MP0000955_abnormal_spinal_cord | 1.54255876 |
| 37 | MP0001970_abnormal_pain_threshold | 1.53901502 |
| 38 | MP0005645_abnormal_hypothalamus_physiol | 1.48193519 |
| 39 | MP0008569_lethality_at_weaning | 1.44552747 |
| 40 | MP0008438_abnormal_cutaneous_collagen | 1.44365651 |
| 41 | MP0002067_abnormal_sensory_capabilities | 1.37963761 |
| 42 | MP0005410_abnormal_fertilization | 1.36562988 |
| 43 | MP0004885_abnormal_endolymph | 1.32788315 |
| 44 | MP0006276_abnormal_autonomic_nervous | 1.32503694 |
| 45 | MP0004272_abnormal_basement_membrane | 1.28438003 |
| 46 | MP0002909_abnormal_adrenal_gland | 1.27794924 |
| 47 | MP0002882_abnormal_neuron_morphology | 1.27417837 |
| 48 | MP0004924_abnormal_behavior | 1.21269862 |
| 49 | MP0005386_behavior/neurological_phenoty | 1.21269862 |
| 50 | MP0000751_myopathy | 1.19881403 |
| 51 | MP0005646_abnormal_pituitary_gland | 1.19423282 |
| 52 | MP0005508_abnormal_skeleton_morphology | 1.13329745 |
| 53 | MP0001905_abnormal_dopamine_level | 1.13053912 |
| 54 | MP0002066_abnormal_motor_capabilities/c | 1.12793820 |
| 55 | MP0002152_abnormal_brain_morphology | 1.11525459 |
| 56 | MP0009379_abnormal_foot_pigmentation | 1.11455101 |
| 57 | MP0004133_heterotaxia | 1.11418233 |
| 58 | MP0001348_abnormal_lacrimal_gland | 1.11135513 |
| 59 | MP0001299_abnormal_eye_distance/ | 1.10654389 |
| 60 | MP0003385_abnormal_body_wall | 1.10637901 |
| 61 | MP0001177_atelectasis | 1.10546508 |
| 62 | MP0005377_hearing/vestibular/ear_phenot | 1.07735184 |
| 63 | MP0003878_abnormal_ear_physiology | 1.07735184 |
| 64 | MP0009384_cardiac_valve_regurgitation | 1.07575354 |
| 65 | MP0000534_abnormal_ureter_morphology | 1.05553946 |
| 66 | MP0004233_abnormal_muscle_weight | 1.01325147 |
| 67 | MP0001502_abnormal_circadian_rhythm | 0.98792248 |
| 68 | MP0002234_abnormal_pharynx_morphology | 0.97201305 |
| 69 | MP0000678_abnormal_parathyroid_gland | 0.96485385 |
| 70 | MP0005275_abnormal_skin_tensile | 0.93080570 |
| 71 | MP0002089_abnormal_postnatal_growth/wei | 0.92085635 |
| 72 | MP0003861_abnormal_nervous_system | 0.91768232 |
| 73 | MP0003633_abnormal_nervous_system | 0.91363258 |
| 74 | MP0002295_abnormal_pulmonary_circulatio | 0.91134642 |
| 75 | MP0005409_darkened_coat_color | 0.90031532 |
| 76 | MP0003329_amyloid_beta_deposits | 0.88258069 |
| 77 | MP0008961_abnormal_basal_metabolism | 0.88025884 |
| 78 | MP0000003_abnormal_adipose_tissue | 0.86566282 |
| 79 | MP0010030_abnormal_orbit_morphology | 0.86051436 |
| 80 | MP0000026_abnormal_inner_ear | 0.84023949 |
| 81 | MP0005595_abnormal_vascular_smooth | 0.83523843 |
| 82 | MP0002932_abnormal_joint_morphology | 0.82878763 |
| 83 | MP0005394_taste/olfaction_phenotype | 0.82402754 |
| 84 | MP0005499_abnormal_olfactory_system | 0.82402754 |
| 85 | MP0006292_abnormal_olfactory_placode | 0.82018913 |
| 86 | MP0010368_abnormal_lymphatic_system | 0.81527804 |
| 87 | MP0001542_abnormal_bone_strength | 0.80499315 |
| 88 | MP0003705_abnormal_hypodermis_morpholog | 0.80493868 |
| 89 | MP0003121_genomic_imprinting | 0.80418930 |
| 90 | MP0003123_paternal_imprinting | 0.79400994 |
| 91 | MP0003045_fibrosis | 0.79294380 |
| 92 | MP0000733_abnormal_muscle_development | 0.77984318 |
| 93 | MP0010386_abnormal_urinary_bladder | 0.77122352 |
| 94 | MP0003119_abnormal_digestive_system | 0.77045537 |
| 95 | MP0003279_aneurysm | 0.76910497 |
| 96 | MP0003631_nervous_system_phenotype | 0.75295765 |
| 97 | MP0003942_abnormal_urinary_system | 0.74653238 |
| 98 | MP0000013_abnormal_adipose_tissue | 0.74569532 |
| 99 | MP0009053_abnormal_anal_canal | 0.74310875 |
| 100 | MP0002069_abnormal_eating/drinking_beha | 0.74239624 |
| 101 | MP0000631_abnormal_neuroendocrine_gland | 0.73641450 |
| 102 | MP0001963_abnormal_hearing_physiology | 0.73612505 |
| 103 | MP0002108_abnormal_muscle_morphology | 0.73502798 |
| 104 | MP0005257_abnormal_intraocular_pressure | 0.71823651 |
| 105 | MP0003075_altered_response_to | 0.71703864 |
| 106 | MP0004130_abnormal_muscle_cell | 0.71573374 |
| 107 | MP0003755_abnormal_palate_morphology | 0.70846207 |
| 108 | MP0002249_abnormal_larynx_morphology | 0.70119752 |
| 109 | MP0003115_abnormal_respiratory_system | 0.69842948 |
| 110 | MP0004085_abnormal_heartbeat | 0.69694180 |
| 111 | MP0004742_abnormal_vestibular_system | 0.69427255 |
| 112 | MP0008004_abnormal_stomach_pH | 0.68635430 |
| 113 | MP0005551_abnormal_eye_electrophysiolog | 0.67711694 |
| 114 | MP0004145_abnormal_muscle_electrophysio | 0.67556384 |
| 115 | MP0009250_abnormal_appendicular_skeleto | 0.67539196 |
| 116 | MP0000049_abnormal_middle_ear | 0.67475442 |
| 117 | MP0002116_abnormal_craniofacial_bone | 0.67294438 |
| 118 | MP0001485_abnormal_pinna_reflex | 0.67187580 |
| 119 | MP0001984_abnormal_olfaction | 0.66475855 |
| 120 | MP0003634_abnormal_glial_cell | 0.66100438 |
| 121 | MP0002081_perinatal_lethality | 0.65522373 |
| 122 | MP0001188_hyperpigmentation | 0.65173020 |
| 123 | MP0002653_abnormal_ependyma_morphology | 0.65001320 |
| 124 | MP0002752_abnormal_somatic_nervous | 0.64147182 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 4.90353722 |
| 2 | Focal motor seizures (HP:0011153) | 4.58899007 |
| 3 | Focal seizures (HP:0007359) | 3.94785215 |
| 4 | Visual hallucinations (HP:0002367) | 3.33481077 |
| 5 | Epileptic encephalopathy (HP:0200134) | 3.26939180 |
| 6 | Action tremor (HP:0002345) | 3.02452706 |
| 7 | Febrile seizures (HP:0002373) | 2.98180792 |
| 8 | Shallow orbits (HP:0000586) | 2.95580556 |
| 9 | Progressive cerebellar ataxia (HP:0002073) | 2.94532023 |
| 10 | Abnormality of the lower motor neuron (HP:0002366) | 2.83501025 |
| 11 | Spinal rigidity (HP:0003306) | 2.81894996 |
| 12 | Follicular hyperkeratosis (HP:0007502) | 2.74654794 |
| 13 | Protrusio acetabuli (HP:0003179) | 2.65606022 |
| 14 | Atonic seizures (HP:0010819) | 2.63696183 |
| 15 | Type II lissencephaly (HP:0007260) | 2.63467397 |
| 16 | Genetic anticipation (HP:0003743) | 2.62312227 |
| 17 | Ankle clonus (HP:0011448) | 2.52369008 |
| 18 | Abnormality of dentin (HP:0010299) | 2.51945610 |
| 19 | Soft skin (HP:0000977) | 2.49452281 |
| 20 | Pointed chin (HP:0000307) | 2.45542927 |
| 21 | Bladder diverticulum (HP:0000015) | 2.43284088 |
| 22 | Coronal craniosynostosis (HP:0004440) | 2.41742477 |
| 23 | Fragile skin (HP:0001030) | 2.38019640 |
| 24 | Abnormality of the aortic arch (HP:0012303) | 2.36782232 |
| 25 | Premature rupture of membranes (HP:0001788) | 2.36583910 |
| 26 | Lower limb amyotrophy (HP:0007210) | 2.35953229 |
| 27 | Insomnia (HP:0100785) | 2.35893723 |
| 28 | Poor eye contact (HP:0000817) | 2.31424723 |
| 29 | Hyperacusis (HP:0010780) | 2.28561661 |
| 30 | Supranuclear gaze palsy (HP:0000605) | 2.27693532 |
| 31 | Renal duplication (HP:0000075) | 2.25718494 |
| 32 | Generalized tonic-clonic seizures (HP:0002069) | 2.25223231 |
| 33 | Obstructive sleep apnea (HP:0002870) | 2.23651296 |
| 34 | Absence seizures (HP:0002121) | 2.22210255 |
| 35 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.22067402 |
| 36 | Sleep apnea (HP:0010535) | 2.20737270 |
| 37 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.19061725 |
| 38 | Peritonitis (HP:0002586) | 2.18789100 |
| 39 | Genu recurvatum (HP:0002816) | 2.18570815 |
| 40 | Depression (HP:0000716) | 2.18556021 |
| 41 | Bowel diverticulosis (HP:0005222) | 2.18201176 |
| 42 | Annular pancreas (HP:0001734) | 2.15256876 |
| 43 | Broad-based gait (HP:0002136) | 2.13023480 |
| 44 | Shawl scrotum (HP:0000049) | 2.12433694 |
| 45 | Amblyopia (HP:0000646) | 2.12347224 |
| 46 | Torticollis (HP:0000473) | 2.11843672 |
| 47 | Hypoventilation (HP:0002791) | 2.11745785 |
| 48 | Broad metatarsal (HP:0001783) | 2.09517169 |
| 49 | Impaired social interactions (HP:0000735) | 2.07937468 |
| 50 | Abnormal social behavior (HP:0012433) | 2.07937468 |
| 51 | Hand muscle atrophy (HP:0009130) | 2.07806006 |
| 52 | Mitral regurgitation (HP:0001653) | 2.06483517 |
| 53 | Aortic dissection (HP:0002647) | 2.06139903 |
| 54 | Dialeptic seizures (HP:0011146) | 2.04375784 |
| 55 | Gaze-evoked nystagmus (HP:0000640) | 2.03706570 |
| 56 | Hemiplegia (HP:0002301) | 2.02996859 |
| 57 | Type 1 muscle fiber predominance (HP:0003803) | 2.02959316 |
| 58 | Neoplasm of the heart (HP:0100544) | 2.02949521 |
| 59 | Flat cornea (HP:0007720) | 2.01908687 |
| 60 | Cerebral aneurysm (HP:0004944) | 2.00715853 |
| 61 | Elfin facies (HP:0004428) | 2.00517011 |
| 62 | Wrist flexion contracture (HP:0001239) | 1.99559965 |
| 63 | Atelectasis (HP:0100750) | 1.97385746 |
| 64 | Impaired smooth pursuit (HP:0007772) | 1.97315771 |
| 65 | Vascular tortuosity (HP:0004948) | 1.96509231 |
| 66 | Unilateral renal agenesis (HP:0000122) | 1.95910379 |
| 67 | Megalencephaly (HP:0001355) | 1.95351296 |
| 68 | Postural instability (HP:0002172) | 1.94247748 |
| 69 | Dysdiadochokinesis (HP:0002075) | 1.93853371 |
| 70 | Aortic aneurysm (HP:0004942) | 1.89121176 |
| 71 | Buphthalmos (HP:0000557) | 1.88566096 |
| 72 | Retinal dysplasia (HP:0007973) | 1.88271845 |
| 73 | Renovascular hypertension (HP:0100817) | 1.87945939 |
| 74 | Megalocornea (HP:0000485) | 1.87606388 |
| 75 | Distal upper limb amyotrophy (HP:0007149) | 1.87532814 |
| 76 | Upper limb amyotrophy (HP:0009129) | 1.87532814 |
| 77 | Papilledema (HP:0001085) | 1.86547242 |
| 78 | Narrow nasal bridge (HP:0000446) | 1.86277576 |
| 79 | Turricephaly (HP:0000262) | 1.85783048 |
| 80 | Hemiparesis (HP:0001269) | 1.85462921 |
| 81 | Stereotypic behavior (HP:0000733) | 1.85070742 |
| 82 | Infantile muscular hypotonia (HP:0008947) | 1.84960711 |
| 83 | Bulbous nose (HP:0000414) | 1.84338605 |
| 84 | Excessive salivation (HP:0003781) | 1.83079832 |
| 85 | Drooling (HP:0002307) | 1.83079832 |
| 86 | Neonatal short-limb short stature (HP:0008921) | 1.82337264 |
| 87 | Fetal akinesia sequence (HP:0001989) | 1.82243947 |
| 88 | Ankyloglossia (HP:0010296) | 1.81579772 |
| 89 | Focal dystonia (HP:0004373) | 1.79023124 |
| 90 | Bronchomalacia (HP:0002780) | 1.78872458 |
| 91 | Bell-shaped thorax (HP:0001591) | 1.78413453 |
| 92 | Stridor (HP:0010307) | 1.77427597 |
| 93 | Abnormality of binocular vision (HP:0011514) | 1.77384974 |
| 94 | Diplopia (HP:0000651) | 1.77384974 |
| 95 | Mutism (HP:0002300) | 1.76717552 |
| 96 | Truncal ataxia (HP:0002078) | 1.76423907 |
| 97 | Dilatation of the ascending aorta (HP:0005111) | 1.75477636 |
| 98 | Hyperthyroidism (HP:0000836) | 1.74993022 |
| 99 | Wormian bones (HP:0002645) | 1.73825840 |
| 100 | Blue sclerae (HP:0000592) | 1.73756922 |
| 101 | Ectopia lentis (HP:0001083) | 1.73729256 |
| 102 | Wide anterior fontanel (HP:0000260) | 1.73413681 |
| 103 | Aortic regurgitation (HP:0001659) | 1.73095085 |
| 104 | Urinary urgency (HP:0000012) | 1.73094798 |
| 105 | Spinal canal stenosis (HP:0003416) | 1.73043302 |
| 106 | Overriding aorta (HP:0002623) | 1.72060272 |
| 107 | Hypoplasia of the brainstem (HP:0002365) | 1.72052418 |
| 108 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.72052418 |
| 109 | Deviation of the hallux (HP:0010051) | 1.71150310 |
| 110 | Alopecia of scalp (HP:0002293) | 1.70240833 |
| 111 | Dysmetria (HP:0001310) | 1.69895846 |
| 112 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.68888930 |
| 113 | Short 4th metacarpal (HP:0010044) | 1.68888930 |
| 114 | Joint laxity (HP:0001388) | 1.68273661 |
| 115 | Long toe (HP:0010511) | 1.68136995 |
| 116 | Abnormal eating behavior (HP:0100738) | 1.67725730 |
| 117 | Congenital glaucoma (HP:0001087) | 1.67381603 |
| 118 | Overgrowth (HP:0001548) | 1.67031693 |
| 119 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.66915937 |
| 120 | Hallux valgus (HP:0001822) | 1.66389971 |
| 121 | Atrophic scars (HP:0001075) | 1.65047120 |
| 122 | Akinesia (HP:0002304) | 1.64820976 |
| 123 | Increased variability in muscle fiber diameter (HP:0003557) | 1.64479679 |
| 124 | Dysmetric saccades (HP:0000641) | 1.64267591 |
| 125 | Slender build (HP:0001533) | 1.63663932 |
| 126 | Round ear (HP:0100830) | 1.63174574 |
| 127 | Ulnar bowing (HP:0003031) | 1.62778819 |
| 128 | Protruding ear (HP:0000411) | 1.61618531 |
| 129 | Absent speech (HP:0001344) | 1.60798013 |
| 130 | Ventricular fibrillation (HP:0001663) | 1.60335431 |
| 131 | Aqueductal stenosis (HP:0002410) | 1.60014302 |
| 132 | Ankle contracture (HP:0006466) | 1.60007177 |
| 133 | Cervical subluxation (HP:0003308) | 1.59537651 |
| 134 | Bradycardia (HP:0001662) | 1.59431925 |
| 135 | Increased corneal curvature (HP:0100692) | 1.58937507 |
| 136 | Keratoconus (HP:0000563) | 1.58937507 |
| 137 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.57968172 |
| 138 | Mild short stature (HP:0003502) | 1.57773023 |
| 139 | Anxiety (HP:0000739) | 1.57044976 |
| 140 | Morphological abnormality of the middle ear (HP:0008609) | 1.56658266 |
| 141 | Cutaneous finger syndactyly (HP:0010554) | 1.55998430 |
| 142 | Bundle branch block (HP:0011710) | 1.54973849 |
| 143 | Hyperextensible skin (HP:0000974) | 1.54061599 |
| 144 | Macroorchidism (HP:0000053) | 1.53771520 |
| 145 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.53543104 |
| 146 | Aplasia of the phalanges of the hand (HP:0009802) | 1.53543104 |
| 147 | Aplasia involving bones of the extremities (HP:0009825) | 1.53543104 |
| 148 | Distal lower limb amyotrophy (HP:0008944) | 1.51912992 |
| 149 | Craniofacial dystonia (HP:0012179) | 1.50712708 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 4.09472711 |
| 2 | EPHA4 | 3.94010889 |
| 3 | MAP3K9 | 3.45194221 |
| 4 | MARK1 | 3.08028001 |
| 5 | PRKD3 | 2.98425124 |
| 6 | TESK1 | 2.49242507 |
| 7 | SIK2 | 2.45359937 |
| 8 | MINK1 | 2.43852484 |
| 9 | LATS2 | 2.42314852 |
| 10 | DAPK2 | 2.39808350 |
| 11 | PAK6 | 2.35997215 |
| 12 | MAP3K4 | 2.25463858 |
| 13 | SIK3 | 2.04617772 |
| 14 | NTRK2 | 2.02867406 |
| 15 | DDR2 | 1.93549552 |
| 16 | CAMKK1 | 1.92776994 |
| 17 | PRPF4B | 1.84247020 |
| 18 | STK38 | 1.79132794 |
| 19 | NTRK1 | 1.74395293 |
| 20 | KSR2 | 1.74158005 |
| 21 | MAPK15 | 1.69567689 |
| 22 | KSR1 | 1.69105552 |
| 23 | MAP2K7 | 1.54179341 |
| 24 | TYRO3 | 1.51182185 |
| 25 | CDK5 | 1.36205867 |
| 26 | PDGFRA | 1.34708427 |
| 27 | DAPK1 | 1.30055432 |
| 28 | MAPK13 | 1.29541001 |
| 29 | MARK2 | 1.29486185 |
| 30 | ALK | 1.27133473 |
| 31 | RIPK1 | 1.24934671 |
| 32 | TAOK1 | 1.23719308 |
| 33 | PLK2 | 1.14989810 |
| 34 | MAP2K4 | 1.12824390 |
| 35 | SIK1 | 1.12412645 |
| 36 | LIMK1 | 1.12055388 |
| 37 | TRIB3 | 1.10310744 |
| 38 | BMX | 1.08017536 |
| 39 | CAMK1 | 1.07152754 |
| 40 | WNK4 | 1.04918190 |
| 41 | DYRK2 | 1.04065937 |
| 42 | INSRR | 1.03606856 |
| 43 | PRKCG | 1.02091671 |
| 44 | PAK2 | 0.97488671 |
| 45 | PRKCH | 0.96180263 |
| 46 | UHMK1 | 0.94842970 |
| 47 | BRAF | 0.94192439 |
| 48 | GRK5 | 0.93636558 |
| 49 | EEF2K | 0.93434629 |
| 50 | MTOR | 0.93388547 |
| 51 | ICK | 0.91504729 |
| 52 | PAK3 | 0.91409070 |
| 53 | STK11 | 0.90159201 |
| 54 | CAMK1D | 0.89236591 |
| 55 | DMPK | 0.88974540 |
| 56 | TNIK | 0.87637122 |
| 57 | CDK18 | 0.86948467 |
| 58 | PKN1 | 0.86598323 |
| 59 | CDK15 | 0.85903888 |
| 60 | MAP3K2 | 0.84429371 |
| 61 | CDC42BPA | 0.84328130 |
| 62 | ADRBK2 | 0.82433318 |
| 63 | RET | 0.81804995 |
| 64 | PHKG2 | 0.80419925 |
| 65 | PHKG1 | 0.80419925 |
| 66 | CDK14 | 0.78503087 |
| 67 | CAMK4 | 0.77340239 |
| 68 | PDPK1 | 0.76504994 |
| 69 | SGK3 | 0.76389778 |
| 70 | MAP3K12 | 0.73699405 |
| 71 | CDK11A | 0.73248230 |
| 72 | CASK | 0.72337913 |
| 73 | EPHB2 | 0.71697344 |
| 74 | MAP2K2 | 0.70944009 |
| 75 | TNK2 | 0.69177515 |
| 76 | LATS1 | 0.68021435 |
| 77 | SGK2 | 0.67332672 |
| 78 | PTK2B | 0.67309730 |
| 79 | ERBB3 | 0.66486523 |
| 80 | TAOK2 | 0.66282261 |
| 81 | CAMK2A | 0.66123706 |
| 82 | CAMK1G | 0.65795633 |
| 83 | RIPK4 | 0.65630243 |
| 84 | MAP2K6 | 0.64958404 |
| 85 | ABL2 | 0.63426028 |
| 86 | SGK494 | 0.63273696 |
| 87 | SGK223 | 0.63273696 |
| 88 | CAMK2B | 0.62713085 |
| 89 | FER | 0.62611770 |
| 90 | LMTK2 | 0.62445500 |
| 91 | SGK1 | 0.61884850 |
| 92 | ADRBK1 | 0.61499609 |
| 93 | GRK1 | 0.61317303 |
| 94 | CAMK2G | 0.57411417 |
| 95 | MYLK | 0.57128042 |
| 96 | PINK1 | 0.56944146 |
| 97 | TIE1 | 0.56942233 |
| 98 | MAP3K7 | 0.56805373 |
| 99 | DYRK1B | 0.56792039 |
| 100 | MAP3K13 | 0.55575870 |
| 101 | DYRK1A | 0.55334061 |
| 102 | RPS6KA6 | 0.55113735 |
| 103 | CDK19 | 0.54919623 |
| 104 | HIPK2 | 0.54847326 |
| 105 | ROCK2 | 0.53743121 |
| 106 | RPS6KL1 | 0.53304745 |
| 107 | RPS6KC1 | 0.53304745 |
| 108 | PTK2 | 0.53111154 |
| 109 | PRKD2 | 0.52436208 |
| 110 | RPS6KA2 | 0.51586767 |
| 111 | DAPK3 | 0.51452406 |
| 112 | CAMKK2 | 0.51246552 |
| 113 | CDK12 | 0.51015165 |
| 114 | MAP3K11 | 0.50703638 |
| 115 | PKN2 | 0.50295754 |
| 116 | MAPK10 | 0.50247030 |
| 117 | WNK1 | 0.49156752 |
| 118 | BRD4 | 0.48791658 |
| 119 | NEK1 | 0.48395368 |
| 120 | RPS6KA3 | 0.47610370 |
| 121 | PRKCZ | 0.47562470 |
| 122 | PDGFRB | 0.47474740 |
| 123 | FGFR1 | 0.47374123 |
| 124 | PRKAA1 | 0.47370709 |
| 125 | BRSK1 | 0.46658272 |
| 126 | FES | 0.46548249 |
| 127 | ROCK1 | 0.45704038 |
| 128 | RAF1 | 0.42810603 |
| 129 | MAP2K1 | 0.41679252 |
| 130 | ARAF | 0.40311763 |
| 131 | MAPK8 | 0.40040612 |
| 132 | FYN | 0.37779906 |
| 133 | PRKCE | 0.32940419 |
| 134 | GSK3B | 0.32055395 |
| 135 | PNCK | 0.31738009 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 2.83367656 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.71545616 |
| 3 | Circadian entrainment_Homo sapiens_hsa04713 | 2.34096324 |
| 4 | Olfactory transduction_Homo sapiens_hsa04740 | 2.33594970 |
| 5 | Long-term potentiation_Homo sapiens_hsa04720 | 2.18575077 |
| 6 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.13135535 |
| 7 | GABAergic synapse_Homo sapiens_hsa04727 | 2.09269773 |
| 8 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.02004745 |
| 9 | Morphine addiction_Homo sapiens_hsa05032 | 2.01825076 |
| 10 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.01776523 |
| 11 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.95383342 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.82850193 |
| 13 | Insulin secretion_Homo sapiens_hsa04911 | 1.79312907 |
| 14 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.75317183 |
| 15 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.72750410 |
| 16 | Salivary secretion_Homo sapiens_hsa04970 | 1.72075672 |
| 17 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.59859277 |
| 18 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.56980925 |
| 19 | Axon guidance_Homo sapiens_hsa04360 | 1.53616982 |
| 20 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.53607940 |
| 21 | Glioma_Homo sapiens_hsa05214 | 1.47630948 |
| 22 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.47373965 |
| 23 | Cocaine addiction_Homo sapiens_hsa05030 | 1.47128546 |
| 24 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.44437700 |
| 25 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.42836775 |
| 26 | Long-term depression_Homo sapiens_hsa04730 | 1.42802908 |
| 27 | Taste transduction_Homo sapiens_hsa04742 | 1.37090052 |
| 28 | Gap junction_Homo sapiens_hsa04540 | 1.35169436 |
| 29 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.31959452 |
| 30 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.31406197 |
| 31 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.30962322 |
| 32 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.26667931 |
| 33 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.26363788 |
| 34 | Renin secretion_Homo sapiens_hsa04924 | 1.24403260 |
| 35 | Phototransduction_Homo sapiens_hsa04744 | 1.23344626 |
| 36 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.23062508 |
| 37 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.22962500 |
| 38 | Melanogenesis_Homo sapiens_hsa04916 | 1.21882155 |
| 39 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.19609424 |
| 40 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.18200592 |
| 41 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.12129389 |
| 42 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.10052187 |
| 43 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.01284731 |
| 44 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.00872618 |
| 45 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.99640329 |
| 46 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.98430453 |
| 47 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.96323257 |
| 48 | * Notch signaling pathway_Homo sapiens_hsa04330 | 0.92033267 |
| 49 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.91780615 |
| 50 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.91641115 |
| 51 | Endometrial cancer_Homo sapiens_hsa05213 | 0.91578404 |
| 52 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.91179046 |
| 53 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.90447077 |
| 54 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.90443580 |
| 55 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.90244003 |
| 56 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.89375948 |
| 57 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.89353528 |
| 58 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.87158578 |
| 59 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.86543310 |
| 60 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.85972031 |
| 61 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.85465685 |
| 62 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.84071843 |
| 63 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.83206865 |
| 64 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.83164595 |
| 65 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.80937281 |
| 66 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.78834429 |
| 67 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.78794580 |
| 68 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.77055856 |
| 69 | Focal adhesion_Homo sapiens_hsa04510 | 0.76979114 |
| 70 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.76822698 |
| 71 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.74324948 |
| 72 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.73458335 |
| 73 | Prion diseases_Homo sapiens_hsa05020 | 0.73295491 |
| 74 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.73072895 |
| 75 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.72752458 |
| 76 | Sulfur relay system_Homo sapiens_hsa04122 | 0.71868209 |
| 77 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.70778684 |
| 78 | Colorectal cancer_Homo sapiens_hsa05210 | 0.70025153 |
| 79 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.69948845 |
| 80 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.69836868 |
| 81 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.68430443 |
| 82 | Melanoma_Homo sapiens_hsa05218 | 0.67235545 |
| 83 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.67078834 |
| 84 | Endocytosis_Homo sapiens_hsa04144 | 0.64888340 |
| 85 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.63382469 |
| 86 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.62941451 |
| 87 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.62339253 |
| 88 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.61656347 |
| 89 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.60888282 |
| 90 | Adherens junction_Homo sapiens_hsa04520 | 0.59322128 |
| 91 | Bladder cancer_Homo sapiens_hsa05219 | 0.58253909 |
| 92 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.58075252 |
| 93 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.57932481 |
| 94 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.57749212 |
| 95 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.57692409 |
| 96 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.57403318 |
| 97 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.56236180 |
| 98 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.56099424 |
| 99 | Alcoholism_Homo sapiens_hsa05034 | 0.56086300 |
| 100 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.55879947 |
| 101 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.55856455 |
| 102 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.55385164 |
| 103 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.55096735 |
| 104 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.54663624 |
| 105 | Tight junction_Homo sapiens_hsa04530 | 0.53330656 |
| 106 | Amoebiasis_Homo sapiens_hsa05146 | 0.53325630 |
| 107 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.53069520 |
| 108 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.52963321 |
| 109 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.52574805 |
| 110 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.52477688 |
| 111 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.51889609 |
| 112 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.51261035 |
| 113 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.50514063 |
| 114 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.50127756 |
| 115 | Bile secretion_Homo sapiens_hsa04976 | 0.49833295 |
| 116 | Circadian rhythm_Homo sapiens_hsa04710 | 0.49142153 |
| 117 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.47940041 |

