NUP205

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nucleoporin, which is a subunit of the nuclear pore complex that functions in active transport of proteins, RNAs and ribonucleoprotein particles between the nucleus and cytoplasm. Mutations in this gene are associated with steroid-resistant nephrotic syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.17588666
2DNA replication-dependent nucleosome organization (GO:0034723)5.24734160
3DNA replication-dependent nucleosome assembly (GO:0006335)5.24734160
4protein localization to chromosome, centromeric region (GO:0071459)5.23961352
5mitotic sister chromatid segregation (GO:0000070)5.09675128
6heterochromatin organization (GO:0070828)4.97895115
7DNA strand elongation (GO:0022616)4.90298126
8sister chromatid segregation (GO:0000819)4.87960696
9* nuclear pore complex assembly (GO:0051292)4.87100490
10* nuclear pore organization (GO:0006999)4.77344781
11DNA unwinding involved in DNA replication (GO:0006268)4.65151413
12chromatin assembly (GO:0031497)4.56241698
13pre-miRNA processing (GO:0031054)4.47151375
14negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.44592966
15mitotic chromosome condensation (GO:0007076)4.35649477
16regulation of telomere maintenance via telomerase (GO:0032210)4.23708146
17DNA topological change (GO:0006265)4.21591995
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.19497770
19telomere maintenance via semi-conservative replication (GO:0032201)4.16946491
20DNA duplex unwinding (GO:0032508)4.16794866
21DNA geometric change (GO:0032392)4.13952996
22negative regulation of cell cycle G2/M phase transition (GO:1902750)4.11788329
23establishment of integrated proviral latency (GO:0075713)4.11294320
24regulation of histone H3-K9 methylation (GO:0051570)3.96029732
25histone H4-K8 acetylation (GO:0043982)3.91862762
26histone H4-K5 acetylation (GO:0043981)3.91862762
27mitotic sister chromatid cohesion (GO:0007064)3.87561539
28protein complex localization (GO:0031503)3.86450306
29polyketide metabolic process (GO:0030638)3.78018617
30doxorubicin metabolic process (GO:0044598)3.78018617
31daunorubicin metabolic process (GO:0044597)3.78018617
32regulation of sister chromatid cohesion (GO:0007063)3.77607912
33* mitotic nuclear envelope disassembly (GO:0007077)3.76178830
34RNA stabilization (GO:0043489)3.72816670
35mRNA stabilization (GO:0048255)3.72816670
36piRNA metabolic process (GO:0034587)3.72203136
37histone H4-K12 acetylation (GO:0043983)3.69648123
38non-recombinational repair (GO:0000726)3.69450146
39double-strand break repair via nonhomologous end joining (GO:0006303)3.69450146
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.64490418
41DNA replication checkpoint (GO:0000076)3.64125623
42mitotic recombination (GO:0006312)3.64118188
43telomere maintenance via recombination (GO:0000722)3.62832693
44cellular protein complex localization (GO:0034629)3.62651614
45DNA replication initiation (GO:0006270)3.60551274
46chromosome condensation (GO:0030261)3.59481233
47cilium or flagellum-dependent cell motility (GO:0001539)3.57493994
48negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.56207912
49negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.56196161
50* membrane disassembly (GO:0030397)3.52091805
51* nuclear envelope disassembly (GO:0051081)3.52091805
52* pore complex assembly (GO:0046931)3.50482289
53fusion of sperm to egg plasma membrane (GO:0007342)3.49852525
54regulation of gene silencing by RNA (GO:0060966)3.49186396
55regulation of posttranscriptional gene silencing (GO:0060147)3.49186396
56regulation of gene silencing by miRNA (GO:0060964)3.49186396
57DNA conformation change (GO:0071103)3.47842674
58regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45401815
59DNA synthesis involved in DNA repair (GO:0000731)3.44030975
60regulation of mitotic spindle organization (GO:0060236)3.41894260
61gene silencing by RNA (GO:0031047)3.39960859
62metaphase plate congression (GO:0051310)3.39541592
63negative regulation of histone methylation (GO:0031061)3.35685358
64protein export from nucleus (GO:0006611)3.33755358
65ribosome assembly (GO:0042255)3.33087672
66spliceosomal tri-snRNP complex assembly (GO:0000244)3.32116046
67regulation of response to osmotic stress (GO:0047484)3.31877636
68chromatin assembly or disassembly (GO:0006333)3.31630301
69protein localization to chromosome (GO:0034502)3.30920673
70regulation of nucleobase-containing compound transport (GO:0032239)3.30127134
71maintenance of protein location in nucleus (GO:0051457)3.27799004
72IMP metabolic process (GO:0046040)3.26391014
73formation of translation preinitiation complex (GO:0001731)3.25743429
74folic acid-containing compound biosynthetic process (GO:0009396)3.24787410
75negative regulation of telomerase activity (GO:0051974)3.23531528
76DNA packaging (GO:0006323)3.21182855
77NLS-bearing protein import into nucleus (GO:0006607)3.20742338
78negative regulation of DNA repair (GO:0045738)3.20577294
79* nuclear envelope organization (GO:0006998)3.19055771
80negative regulation of epidermis development (GO:0045683)3.18875156
81nucleobase biosynthetic process (GO:0046112)3.14456896
82spindle assembly (GO:0051225)3.14072114
83synaptonemal complex assembly (GO:0007130)3.13779440
84regulation of mammary gland epithelial cell proliferation (GO:0033599)3.12992206
85histone H4-K16 acetylation (GO:0043984)3.12149047
86regulation of cilium movement (GO:0003352)3.10165902
87rRNA transcription (GO:0009303)3.08607036
88negative regulation of mRNA processing (GO:0050686)3.08502500
89spindle checkpoint (GO:0031577)3.07825563
90purine nucleobase biosynthetic process (GO:0009113)3.07235330
91establishment of chromosome localization (GO:0051303)3.07142346
92regulation of DNA damage checkpoint (GO:2000001)3.05746610
93negative regulation of mitotic sister chromatid separation (GO:2000816)3.05644461
94negative regulation of sister chromatid segregation (GO:0033046)3.05644461
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05644461
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05644461
97negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05644461
98male meiosis (GO:0007140)3.04041705
99regulation of chromosome segregation (GO:0051983)3.03651517
100establishment of viral latency (GO:0019043)3.03589376
101negative regulation of mRNA metabolic process (GO:1903312)3.02784794
102regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02129733
103regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02129733
104mitotic spindle checkpoint (GO:0071174)3.01717253
105protein-DNA complex disassembly (GO:0032986)3.00954333
106nucleosome disassembly (GO:0006337)3.00954333
107ATP-dependent chromatin remodeling (GO:0043044)3.00630415
108regulation of double-strand break repair (GO:2000779)3.00297606
109translesion synthesis (GO:0019985)2.99994007
110regulation of sister chromatid segregation (GO:0033045)2.99771116
111regulation of mitotic sister chromatid separation (GO:0010965)2.99771116
112regulation of mitotic sister chromatid segregation (GO:0033047)2.99771116
113positive regulation of cell cycle checkpoint (GO:1901978)2.99371521
114kinetochore organization (GO:0051383)2.99242877
115mitotic spindle assembly checkpoint (GO:0007094)2.97403345
116* mRNA transport (GO:0051028)2.97042073
117regulation of centriole replication (GO:0046599)2.96984142
118synaptonemal complex organization (GO:0070193)2.96337834
119positive regulation of DNA-dependent DNA replication (GO:2000105)2.96333289
120attachment of spindle microtubules to kinetochore (GO:0008608)2.95715544
121regulation of hippo signaling (GO:0035330)2.93043051
122CENP-A containing nucleosome assembly (GO:0034080)2.92838282
123tRNA aminoacylation for protein translation (GO:0006418)2.92500115
124DNA ligation (GO:0006266)2.92440659
125mitotic metaphase plate congression (GO:0007080)2.91984658
126nucleotide-excision repair, DNA gap filling (GO:0006297)2.91088383
127positive regulation of chromosome segregation (GO:0051984)2.89910112
128regulation of RNA export from nucleus (GO:0046831)2.89566601
129regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.88562405
130gene silencing (GO:0016458)2.83574208
131regulation of translation in response to stress (GO:0043555)2.83028066
132regulation of translational fidelity (GO:0006450)2.82236547
133ribosome biogenesis (GO:0042254)2.80910794
134trophectodermal cell differentiation (GO:0001829)2.80789170
135chromosome segregation (GO:0007059)2.79985247
136DNA strand elongation involved in DNA replication (GO:0006271)2.79450939
137dosage compensation (GO:0007549)2.77972453
138IMP biosynthetic process (GO:0006188)2.76820321
139binding of sperm to zona pellucida (GO:0007339)2.76627453
140spindle assembly checkpoint (GO:0071173)2.74711226
141acrosome assembly (GO:0001675)2.74553048
142regulation of gene silencing (GO:0060968)2.74433210
143regulation of centrosome cycle (GO:0046605)2.74187265
144DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.73327849
145regulation of spindle organization (GO:0090224)2.72831378
146sperm-egg recognition (GO:0035036)2.72722048
147somatic diversification of immune receptors via somatic mutation (GO:0002566)2.71520411
148somatic hypermutation of immunoglobulin genes (GO:0016446)2.71520411
149notochord development (GO:0030903)2.71407271
150positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.71125878
151positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.71125878
152positive regulation of mitotic sister chromatid separation (GO:1901970)2.71125878
153negative regulation of chromosome segregation (GO:0051985)2.70515375

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.25974414
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.03914659
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.47308137
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.08431551
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.44168211
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.44168211
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.44168211
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.16176191
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.97557411
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.55724567
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.43619552
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42128841
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.41351550
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.36572942
15* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26449186
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16612841
17MYC_22102868_ChIP-Seq_BL_Human2.07581261
18AR_21909140_ChIP-Seq_LNCAP_Human2.06936364
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03761090
20NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.99046259
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.98926280
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96897633
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84515254
24* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.79397926
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77702831
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.73623775
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66784129
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.65201943
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64917854
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62740682
31TCF3_18692474_ChIP-Seq_MESCs_Mouse1.62170660
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60752038
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59367264
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59237646
35SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.56466608
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.55847751
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52333621
38* XRN2_22483619_ChIP-Seq_HELA_Human1.51945430
39TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51188734
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49651849
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49249655
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46743787
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42423590
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38642936
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37836915
46ZNF263_19887448_ChIP-Seq_K562_Human1.35689592
47CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35574604
48CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.33089112
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32004189
50KDM5A_27292631_Chip-Seq_BREAST_Human1.30510909
51NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.29681442
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28548429
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25304686
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25195261
55* FOXP3_21729870_ChIP-Seq_TREG_Human1.24855151
56* EST1_17652178_ChIP-ChIP_JURKAT_Human1.23659579
57CHD1_26751641_Chip-Seq_LNCaP_Human1.22767365
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22739871
59* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22534374
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22326853
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22317351
62* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22309883
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21827135
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21755250
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20443239
66* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20182459
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18783355
68CIITA_25753668_ChIP-Seq_RAJI_Human1.18464693
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.18304141
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17019644
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15706372
72NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.15624805
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14132963
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12467476
75VDR_23849224_ChIP-Seq_CD4+_Human1.11401290
76* TTF2_22483619_ChIP-Seq_HELA_Human1.09555067
77CLOCK_20551151_ChIP-Seq_293T_Human1.08861942
78TCF7_22412390_ChIP-Seq_EML_Mouse1.08671551
79* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07795877
80KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07151379
81* ETS1_20019798_ChIP-Seq_JURKAT_Human1.06456439
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05912232
83SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04972849
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04940463
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04455449
86GABP_19822575_ChIP-Seq_HepG2_Human1.03301912
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02589458
88* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02466729
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02354424
90SOX17_20123909_ChIP-Seq_XEN_Mouse1.01976109
91TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.01686829
92POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.01259603
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00086637
94GABP_17652178_ChIP-ChIP_JURKAT_Human0.98681846
95ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98619219
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97244180
97YY1_21170310_ChIP-Seq_MESCs_Mouse0.96949154
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95904456
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95686446
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95423773
101NANOG_18692474_ChIP-Seq_MESCs_Mouse0.94226258
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94086849
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93477954
104* NCOR1_26117541_ChIP-Seq_K562_Human0.93276176
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92140704
106ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92078615
107TFEB_21752829_ChIP-Seq_HELA_Human0.91660119
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90993831
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90556333
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89911819
111PKCTHETA_26484144_Chip-Seq_BREAST_Human0.89557585
112NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89173135
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88609052
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88492963
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.87473622
116ELK1_19687146_ChIP-ChIP_HELA_Human0.86551136
117TP63_17297297_ChIP-ChIP_HaCaT_Human0.86402313
118HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85112034
119* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84556883
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84540584
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83994846
122* DCP1A_22483619_ChIP-Seq_HELA_Human0.83763910
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83288829
124SOX2_16153702_ChIP-ChIP_HESCs_Human0.83147808
125ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82947647
126ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82832866
127JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.82412602
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81002554
129* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80521007
130* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77717820

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.12202733
2MP0010094_abnormal_chromosome_stability3.44310928
3MP0004957_abnormal_blastocyst_morpholog3.43327068
4MP0003111_abnormal_nucleus_morphology3.15988818
5MP0010352_gastrointestinal_tract_polyps3.05521102
6MP0003077_abnormal_cell_cycle2.95192205
7MP0003705_abnormal_hypodermis_morpholog2.66848669
8MP0003890_abnormal_embryonic-extraembry2.63329120
9MP0003693_abnormal_embryo_hatching2.54630109
10MP0004264_abnormal_extraembryonic_tissu2.50280912
11MP0005410_abnormal_fertilization2.47530717
12MP0002009_preneoplasia2.40324543
13MP0003121_genomic_imprinting2.36429359
14MP0002653_abnormal_ependyma_morphology2.24884715
15MP0003123_paternal_imprinting2.17471110
16MP0008877_abnormal_DNA_methylation2.15662982
17MP0001672_abnormal_embryogenesis/_devel2.14937925
18MP0005380_embryogenesis_phenotype2.14937925
19MP0000350_abnormal_cell_proliferation2.11544669
20MP0008007_abnormal_cellular_replicative2.10119820
21MP0001730_embryonic_growth_arrest2.09302936
22MP0010234_abnormal_vibrissa_follicle2.08210423
23MP0003984_embryonic_growth_retardation1.98737415
24MP0002088_abnormal_embryonic_growth/wei1.97852796
25MP0010307_abnormal_tumor_latency1.94795225
26MP0004233_abnormal_muscle_weight1.93128974
27MP0009697_abnormal_copulation1.87512302
28MP0003941_abnormal_skin_development1.87185839
29MP0008058_abnormal_DNA_repair1.85479429
30MP0002084_abnormal_developmental_patter1.82230530
31MP0004197_abnormal_fetal_growth/weight/1.80348872
32MP0002085_abnormal_embryonic_tissue1.75290034
33MP0006292_abnormal_olfactory_placode1.75142732
34MP0002086_abnormal_extraembryonic_tissu1.72765288
35MP0005257_abnormal_intraocular_pressure1.72152294
36MP0001293_anophthalmia1.69811790
37MP0008932_abnormal_embryonic_tissue1.69152283
38MP0004185_abnormal_adipocyte_glucose1.68320668
39MP0001697_abnormal_embryo_size1.61853923
40MP0002396_abnormal_hematopoietic_system1.61643859
41MP0005076_abnormal_cell_differentiation1.58765256
42MP0001929_abnormal_gametogenesis1.54187450
43MP0003122_maternal_imprinting1.53440872
44MP0003786_premature_aging1.53389086
45MP0003011_delayed_dark_adaptation1.52266442
46MP0001661_extended_life_span1.50581371
47MP0001849_ear_inflammation1.50186955
48MP0002210_abnormal_sex_determination1.47089106
49MP0002254_reproductive_system_inflammat1.46238015
50MP0002080_prenatal_lethality1.45845574
51MP0010030_abnormal_orbit_morphology1.45827686
52MP0005499_abnormal_olfactory_system1.43183811
53MP0005394_taste/olfaction_phenotype1.43183811
54MP0002092_abnormal_eye_morphology1.41042541
55MP0005075_abnormal_melanosome_morpholog1.38043803
56MP0001145_abnormal_male_reproductive1.36964764
57MP0004808_abnormal_hematopoietic_stem1.34304694
58MP0003698_abnormal_male_reproductive1.33004166
59MP0000313_abnormal_cell_death1.28185860
60MP0005623_abnormal_meninges_morphology1.26431633
61MP0000428_abnormal_craniofacial_morphol1.23542171
62MP0000490_abnormal_crypts_of1.21470718
63MP0003119_abnormal_digestive_system1.11827874
64MP0009703_decreased_birth_body1.08060761
65MP0000432_abnormal_head_morphology1.05697036
66MP0003718_maternal_effect1.03674811
67MP0003935_abnormal_craniofacial_develop1.00975664
68MP0002019_abnormal_tumor_incidence1.00036806
69MP0000653_abnormal_sex_gland0.99673199
70MP0003937_abnormal_limbs/digits/tail_de0.99043308
71MP0005451_abnormal_body_composition0.98625462
72MP0003787_abnormal_imprinting0.98432579
73MP0001346_abnormal_lacrimal_gland0.97240600
74MP0003221_abnormal_cardiomyocyte_apopto0.96219188
75MP0002932_abnormal_joint_morphology0.96020122
76MP0002925_abnormal_cardiovascular_devel0.93778018
77MP0005023_abnormal_wound_healing0.93148292
78MP0005501_abnormal_skin_physiology0.92906142
79MP0008961_abnormal_basal_metabolism0.91760038
80MP0002877_abnormal_melanocyte_morpholog0.91410174
81MP0003566_abnormal_cell_adhesion0.90891971
82MP0008770_decreased_survivor_rate0.89496450
83MP0004272_abnormal_basement_membrane0.89114305
84MP0003385_abnormal_body_wall0.88827637
85MP0004858_abnormal_nervous_system0.87923699
86MP0002796_impaired_skin_barrier0.87724739
87MP0009053_abnormal_anal_canal0.87307798
88MP0002697_abnormal_eye_size0.86797821
89MP0002114_abnormal_axial_skeleton0.86470368
90MP0000537_abnormal_urethra_morphology0.86267655
91MP0002233_abnormal_nose_morphology0.84547178
92MP0000579_abnormal_nail_morphology0.84007100
93MP0002161_abnormal_fertility/fecundity0.83008299
94MP0000733_abnormal_muscle_development0.82464201
95MP0003115_abnormal_respiratory_system0.81134154
96MP0000358_abnormal_cell_content/0.81060818
97MP0003283_abnormal_digestive_organ0.80198219
98MP0002332_abnormal_exercise_endurance0.78680901
99MP0002111_abnormal_tail_morphology0.78551379
100MP0009672_abnormal_birth_weight0.78311826
101MP0003938_abnormal_ear_development0.76890990
102MP0003861_abnormal_nervous_system0.76536337
103MP0009278_abnormal_bone_marrow0.76226456
104MP0005384_cellular_phenotype0.76044305
105MP0000377_abnormal_hair_follicle0.75996012
106MP0004133_heterotaxia0.75897730
107MP0003755_abnormal_palate_morphology0.75800535
108MP0002127_abnormal_cardiovascular_syste0.75081072
109MP0000566_synostosis0.74973103
110MP0003453_abnormal_keratinocyte_physiol0.74807654
111MP0005391_vision/eye_phenotype0.73882772
112MP0000703_abnormal_thymus_morphology0.73873273
113MP0003315_abnormal_perineum_morphology0.72389551
114MP0001299_abnormal_eye_distance/0.71751775
115MP0003943_abnormal_hepatobiliary_system0.70958578
116MP0002970_abnormal_white_adipose0.70440820
117MP0003567_abnormal_fetal_cardiomyocyte0.70359707
118MP0000569_abnormal_digit_pigmentation0.70240199
119MP0001286_abnormal_eye_development0.70145657
120MP0010678_abnormal_skin_adnexa0.69745493
121MP0006035_abnormal_mitochondrial_morpho0.69439251
122MP0003942_abnormal_urinary_system0.68696507
123MP0002060_abnormal_skin_morphology0.68560860
124MP0001915_intracranial_hemorrhage0.68445437
125MP0002166_altered_tumor_susceptibility0.67683386
126MP0010630_abnormal_cardiac_muscle0.67559292
127MP0005621_abnormal_cell_physiology0.65484738
128MP0000762_abnormal_tongue_morphology0.65353186
129MP0001216_abnormal_epidermal_layer0.65234163
130MP0002006_tumorigenesis0.64251684
131MP0002116_abnormal_craniofacial_bone0.64216667
132MP0000678_abnormal_parathyroid_gland0.61717837
133MP0002081_perinatal_lethality0.59988001
134MP0000627_abnormal_mammary_gland0.59376287
135MP0005187_abnormal_penis_morphology0.58132924

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.97321265
2Abnormality of the lower motor neuron (HP:0002366)4.78874621
3Bilateral microphthalmos (HP:0007633)4.12062316
4Abnormality of the astrocytes (HP:0100707)3.83933020
5Astrocytoma (HP:0009592)3.83933020
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.78498371
7Chromsome breakage (HP:0040012)3.60876680
8Rhabdomyosarcoma (HP:0002859)3.51976061
9Neoplasm of striated muscle (HP:0009728)3.44032777
10Impulsivity (HP:0100710)3.26349438
11Hypochromic microcytic anemia (HP:0004840)3.24149287
12Selective tooth agenesis (HP:0001592)3.21698514
13Cortical dysplasia (HP:0002539)3.18741142
14Amyotrophic lateral sclerosis (HP:0007354)3.18574877
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.16924144
16Nephroblastoma (Wilms tumor) (HP:0002667)3.11904250
17Multiple enchondromatosis (HP:0005701)3.03720628
18Rib fusion (HP:0000902)3.00917956
19Glioma (HP:0009733)2.97633191
20Medulloblastoma (HP:0002885)2.92078849
21Embryonal renal neoplasm (HP:0011794)2.90332444
22Birth length less than 3rd percentile (HP:0003561)2.87584267
23Meckel diverticulum (HP:0002245)2.82372773
24Ankyloglossia (HP:0010296)2.81240794
25Hepatoblastoma (HP:0002884)2.79104384
26Missing ribs (HP:0000921)2.77903426
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.77368034
28Nasal polyposis (HP:0100582)2.73155691
29Hyperacusis (HP:0010780)2.72413438
30Short humerus (HP:0005792)2.69694978
31Deep philtrum (HP:0002002)2.67138534
32Increased nuchal translucency (HP:0010880)2.66019662
33Aplasia/hypoplasia of the humerus (HP:0006507)2.65935343
34Abnormality of the ileum (HP:0001549)2.64171387
35Volvulus (HP:0002580)2.63354800
36Overlapping toe (HP:0001845)2.60592651
37Hypopigmentation of the fundus (HP:0007894)2.57701985
38Upper motor neuron abnormality (HP:0002127)2.55610645
39Abnormality of the anterior horn cell (HP:0006802)2.50015311
40Degeneration of anterior horn cells (HP:0002398)2.50015311
41Supernumerary spleens (HP:0009799)2.49715506
42Abnormal lung lobation (HP:0002101)2.46764379
43Abnormality of chromosome stability (HP:0003220)2.45816145
44Small intestinal stenosis (HP:0012848)2.42235697
45Duodenal stenosis (HP:0100867)2.42235697
46Reticulocytopenia (HP:0001896)2.41568032
47High anterior hairline (HP:0009890)2.40795004
48Renal duplication (HP:0000075)2.40794428
49Dysmetric saccades (HP:0000641)2.33699193
50Abnormality of oral frenula (HP:0000190)2.33594122
51Insomnia (HP:0100785)2.32457128
52Atrophy/Degeneration involving motor neurons (HP:0007373)2.30003743
53Microvesicular hepatic steatosis (HP:0001414)2.29005726
54Neoplasm of the oral cavity (HP:0100649)2.28355806
55Progressive external ophthalmoplegia (HP:0000590)2.28226645
56Prominent nose (HP:0000448)2.26357848
57Spastic diplegia (HP:0001264)2.25860461
58Aplasia/Hypoplasia of the sternum (HP:0006714)2.25783674
59Insidious onset (HP:0003587)2.25273368
60Termporal pattern (HP:0011008)2.25273368
61Asymmetry of the thorax (HP:0001555)2.23878665
62Sloping forehead (HP:0000340)2.20649901
63Pseudobulbar signs (HP:0002200)2.16769371
64Overriding aorta (HP:0002623)2.16102831
65Abnormality of the preputium (HP:0100587)2.15576685
66Preauricular skin tag (HP:0000384)2.15541558
67Fused cervical vertebrae (HP:0002949)2.14998702
68Myelodysplasia (HP:0002863)2.14842323
69Skin tags (HP:0010609)2.14820958
70Progressive muscle weakness (HP:0003323)2.14187929
71Facial cleft (HP:0002006)2.13886846
72Absent frontal sinuses (HP:0002688)2.12521250
73Heterotopia (HP:0002282)2.11112832
74Abnormality of the nasal mucosa (HP:0000433)2.09756658
75Spinal muscular atrophy (HP:0007269)2.09648334
7611 pairs of ribs (HP:0000878)2.07869992
77Sandal gap (HP:0001852)2.06803321
78Atresia of the external auditory canal (HP:0000413)2.05711152
79Abnormality of the salivary glands (HP:0010286)2.05517275
80Absent radius (HP:0003974)2.05514401
81Hand muscle atrophy (HP:0009130)2.05231558
82Proximal placement of thumb (HP:0009623)2.05127264
83Uterine leiomyosarcoma (HP:0002891)2.04490338
84Leiomyosarcoma (HP:0100243)2.04490338
85Trismus (HP:0000211)2.03854138
86Deviation of the thumb (HP:0009603)2.02637200
87Obsessive-compulsive behavior (HP:0000722)2.01578937
88Large earlobe (HP:0009748)2.00952218
89Abnormality of the calcaneus (HP:0008364)1.98485988
90Cafe-au-lait spot (HP:0000957)1.98441101
91Relative macrocephaly (HP:0004482)1.98333395
92Abnormality of the duodenum (HP:0002246)1.95859186
93Ectopic kidney (HP:0000086)1.95481347
94Septate vagina (HP:0001153)1.94736471
95Abnormality of chromosome segregation (HP:0002916)1.94319736
96Duplication of thumb phalanx (HP:0009942)1.92985542
97Choanal atresia (HP:0000453)1.92158994
98Abnormality of the carotid arteries (HP:0005344)1.91644606
99Skull defect (HP:0001362)1.91333111
100Acute myeloid leukemia (HP:0004808)1.90719756
101Abnormality of cochlea (HP:0000375)1.89531267
102Supernumerary ribs (HP:0005815)1.89269513
103Bifid tongue (HP:0010297)1.88041307
104Abnormality of the distal phalanx of the thumb (HP:0009617)1.85881900
105Rectovaginal fistula (HP:0000143)1.85482750
106Rectal fistula (HP:0100590)1.85482750
107Orthostatic hypotension (HP:0001278)1.85450182
108Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85329465
109Short 4th metacarpal (HP:0010044)1.85329465
110Elfin facies (HP:0004428)1.84524062
111Absent forearm bone (HP:0003953)1.84488667
112Aplasia involving forearm bones (HP:0009822)1.84488667
113Abnormality of the labia minora (HP:0012880)1.83613941
114Dynein arm defect of respiratory motile cilia (HP:0012255)1.82714465
115Absent/shortened dynein arms (HP:0200106)1.82714465
116Gastrointestinal carcinoma (HP:0002672)1.80549245
117Malignant gastrointestinal tract tumors (HP:0006749)1.80549245
118Dislocated radial head (HP:0003083)1.79893799
119Embryonal neoplasm (HP:0002898)1.78838711
120Intestinal fistula (HP:0100819)1.77513546
121Angiofibromas (HP:0010615)1.77008164
122Adenoma sebaceum (HP:0009720)1.77008164
123Colon cancer (HP:0003003)1.76172409
124Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75110780
125Short 5th finger (HP:0009237)1.74140594
126Increased connective tissue (HP:0009025)1.74004832
127Shawl scrotum (HP:0000049)1.73040607
128Glossoptosis (HP:0000162)1.71963557
129Malignant neoplasm of the central nervous system (HP:0100836)1.70294041
130Renovascular hypertension (HP:0100817)1.69563980
131Abnormality of the radial head (HP:0003995)1.68730928
132Supernumerary bones of the axial skeleton (HP:0009144)1.68409636
133Chronic bronchitis (HP:0004469)1.67595503
134Rhinitis (HP:0012384)1.66728621
135Spinal cord lesions (HP:0100561)1.66414171
136Syringomyelia (HP:0003396)1.66414171
137Long eyelashes (HP:0000527)1.65243938
138Abnormal foot bone ossification (HP:0010675)1.64639151
139Hypoplasia of the fovea (HP:0007750)1.64413511
140Aplasia/Hypoplasia of the fovea (HP:0008060)1.64413511
141Ulnar bowing (HP:0003031)1.63934885
142Aplasia/Hypoplasia of the macula (HP:0008059)1.63798282
143Squamous cell carcinoma (HP:0002860)1.63665514
144Tongue fasciculations (HP:0001308)1.63660965
145Microglossia (HP:0000171)1.63094558
146Abnormality of the fingertips (HP:0001211)1.63010294
147Urethral obstruction (HP:0000796)1.62157884
148Transitional cell carcinoma of the bladder (HP:0006740)1.61650747
149Arteriovenous malformation (HP:0100026)1.60866425
150Short middle phalanx of the 5th finger (HP:0004220)1.60144012
151Abnormal number of incisors (HP:0011064)1.60120240
152Patellar dislocation (HP:0002999)1.59846935
153Abnormality of homocysteine metabolism (HP:0010919)1.58086486
154Homocystinuria (HP:0002156)1.58086486
155Deep palmar crease (HP:0006191)1.56416273
156Pointed chin (HP:0000307)1.54693295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.22052696
2CDC73.55379426
3TTK3.01268572
4SMG12.84463618
5NEK22.80705342
6PDK42.69250399
7PDK32.69250399
8WEE12.36539484
9GRK62.33697775
10PBK2.32333238
11ERN12.26424231
12EEF2K2.15436357
13STK102.14534998
14EIF2AK12.02496450
15MAP3K101.94646609
16TYRO31.87222386
17CDK71.76352483
18GRK51.75844995
19CSF1R1.75309739
20TAF11.68972173
21CHEK21.64573575
22PLK11.63905461
23BUB11.60293953
24CHEK11.50975461
25EPHA21.49661431
26PDK21.47347173
27PAK41.40981957
28RPS6KB21.39617170
29NEK11.37375890
30ICK1.36583949
31PKN21.35983711
32ATR1.35349850
33PASK1.34549866
34ZAK1.30106938
35BRD41.27844991
36CDK41.24782652
37CAMK1G1.24735722
38SRPK11.24539275
39NME21.17421039
40ALK1.17211986
41KSR21.16018161
42MTOR1.15591163
43EIF2AK31.14663014
44AURKB1.12493634
45STK31.12024453
46MKNK21.11849911
47MST1R1.10426580
48SCYL21.09237325
49WNK11.06020075
50IRAK31.04170672
51ATM1.01879315
52TGFBR21.01500400
53CLK10.97989826
54TESK10.95544590
55MATK0.94145794
56GRK10.93552925
57BRAF0.91781897
58TRIB30.91522080
59CDK20.90927211
60MAP3K80.90650115
61PRPF4B0.86611466
62MAPK70.85928283
63TTN0.84646124
64ERBB40.83888567
65FGFR40.83499608
66TESK20.82852459
67LATS10.81660622
68STK40.79675519
69ACVR1B0.79453634
70RAF10.78802727
71TLK10.78319606
72CDK80.76282279
73PDGFRA0.75072043
74PAK20.74950633
75EIF2AK20.71968804
76TSSK60.71174082
77KSR10.70754880
78RIPK10.70173075
79PLK30.70045063
80BRSK20.69785089
81ADRBK20.69603445
82AKT20.69227285
83CDK60.69157010
84DYRK30.68773255
85AURKA0.66750647
86CDK10.65563325
87FGFR30.64551531
88MOS0.63752330
89BMX0.62897373
90FLT30.61062827
91MAP3K90.54793707
92PLK40.53693819
93NTRK10.53285060
94PAK10.53042932
95MELK0.52855638
96MKNK10.52016307
97VRK10.51139194
98PRKD30.49258109
99PIM10.48882291
100VRK20.48289121
101CAMK40.47801577
102PNCK0.47258814
103CSNK1E0.46391664
104CAMK1D0.46352792
105CSNK1D0.44511930
106PRKG20.44412285
107TGFBR10.41657076
108RPS6KB10.40891069
109CDK90.39096282
110CSNK2A20.37405232
111MAPK140.36602423
112MARK20.36493706
113PTK60.36395529
114LATS20.36276905
115HIPK20.36191688
116CCNB10.36169593
117CSK0.35509580
118MET0.34024197
119YES10.33696555
120LRRK20.33686142
121CDK150.33525461
122STK240.33145473
123BRSK10.33035423
124CDK180.32498374
125PRKDC0.32469696
126CDK11A0.32232541
127MAP3K20.31987877
128GSK3B0.31115642
129RPS6KA40.31111559
130MAPK10.30560577
131MAPK110.30336361
132PTK20.30319047
133FGFR10.28531439
134DYRK1B0.27649668
135PRKCI0.27423540
136MAPK100.26838216
137NEK60.26568055

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.84427578
2DNA replication_Homo sapiens_hsa030303.54402701
3* RNA transport_Homo sapiens_hsa030133.16666636
4Mismatch repair_Homo sapiens_hsa034303.06172520
5Vitamin B6 metabolism_Homo sapiens_hsa007502.99137763
6Cell cycle_Homo sapiens_hsa041102.77710680
7Fanconi anemia pathway_Homo sapiens_hsa034602.64060710
8One carbon pool by folate_Homo sapiens_hsa006702.60213289
9Spliceosome_Homo sapiens_hsa030402.55455587
10mRNA surveillance pathway_Homo sapiens_hsa030152.53867486
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.35044807
12Homologous recombination_Homo sapiens_hsa034402.21594598
13Base excision repair_Homo sapiens_hsa034102.06879166
14Nucleotide excision repair_Homo sapiens_hsa034201.83495133
15Systemic lupus erythematosus_Homo sapiens_hsa053221.82795385
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.74156441
17RNA degradation_Homo sapiens_hsa030181.67873624
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.65547159
19p53 signaling pathway_Homo sapiens_hsa041151.57792481
20Basal transcription factors_Homo sapiens_hsa030221.56253985
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.54059169
22Non-homologous end-joining_Homo sapiens_hsa034501.54002976
23Fructose and mannose metabolism_Homo sapiens_hsa000511.48613213
24Viral carcinogenesis_Homo sapiens_hsa052031.47669763
25MicroRNAs in cancer_Homo sapiens_hsa052061.35216050
26mTOR signaling pathway_Homo sapiens_hsa041501.31205010
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30195652
28Selenocompound metabolism_Homo sapiens_hsa004501.21672158
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.18745406
30Oocyte meiosis_Homo sapiens_hsa041141.17787407
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16220080
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16195833
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12348121
34Antigen processing and presentation_Homo sapiens_hsa046121.10299455
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09961749
36Thyroid cancer_Homo sapiens_hsa052161.08088449
37HTLV-I infection_Homo sapiens_hsa051661.07658877
38RNA polymerase_Homo sapiens_hsa030201.06553963
39Ribosome_Homo sapiens_hsa030101.02774951
40Basal cell carcinoma_Homo sapiens_hsa052171.02644927
41Pyrimidine metabolism_Homo sapiens_hsa002401.02415639
42Small cell lung cancer_Homo sapiens_hsa052221.01769477
43Herpes simplex infection_Homo sapiens_hsa051681.01278919
44Pentose phosphate pathway_Homo sapiens_hsa000301.00784573
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96513620
46Pyruvate metabolism_Homo sapiens_hsa006200.87988116
47Hippo signaling pathway_Homo sapiens_hsa043900.87910270
48Glioma_Homo sapiens_hsa052140.86251887
49Alcoholism_Homo sapiens_hsa050340.82827739
50Galactose metabolism_Homo sapiens_hsa000520.82736225
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82169833
52Biosynthesis of amino acids_Homo sapiens_hsa012300.82085257
53Adherens junction_Homo sapiens_hsa045200.80614005
54Colorectal cancer_Homo sapiens_hsa052100.78763349
55Epstein-Barr virus infection_Homo sapiens_hsa051690.78333306
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78145472
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76655071
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76021987
59Chronic myeloid leukemia_Homo sapiens_hsa052200.74238708
60N-Glycan biosynthesis_Homo sapiens_hsa005100.73332088
61Lysine degradation_Homo sapiens_hsa003100.71777792
62Notch signaling pathway_Homo sapiens_hsa043300.71730948
63ErbB signaling pathway_Homo sapiens_hsa040120.69236215
64Hedgehog signaling pathway_Homo sapiens_hsa043400.68863400
65Proteoglycans in cancer_Homo sapiens_hsa052050.68853283
66Dorso-ventral axis formation_Homo sapiens_hsa043200.68006571
67Pathways in cancer_Homo sapiens_hsa052000.67712995
68Acute myeloid leukemia_Homo sapiens_hsa052210.66907299
69Non-small cell lung cancer_Homo sapiens_hsa052230.66444131
70Renal cell carcinoma_Homo sapiens_hsa052110.66369860
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64816164
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64539959
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63247294
74Proteasome_Homo sapiens_hsa030500.61291420
75Apoptosis_Homo sapiens_hsa042100.60451245
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60173672
77Insulin signaling pathway_Homo sapiens_hsa049100.59040546
78Inositol phosphate metabolism_Homo sapiens_hsa005620.58612571
79Bladder cancer_Homo sapiens_hsa052190.57927783
80TGF-beta signaling pathway_Homo sapiens_hsa043500.53622716
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52957048
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52716205
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52683365
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52640711
85Linoleic acid metabolism_Homo sapiens_hsa005910.52188815
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51922059
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51854877
88Wnt signaling pathway_Homo sapiens_hsa043100.51811422
89Legionellosis_Homo sapiens_hsa051340.51705860
90Steroid biosynthesis_Homo sapiens_hsa001000.51221742
91Pancreatic cancer_Homo sapiens_hsa052120.49697902
92B cell receptor signaling pathway_Homo sapiens_hsa046620.49019824
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.48974493
94Carbon metabolism_Homo sapiens_hsa012000.48946546
95AMPK signaling pathway_Homo sapiens_hsa041520.47574876
96Melanoma_Homo sapiens_hsa052180.46984743
97Viral myocarditis_Homo sapiens_hsa054160.45802052
98Endometrial cancer_Homo sapiens_hsa052130.44821800
99VEGF signaling pathway_Homo sapiens_hsa043700.44541239
100Tight junction_Homo sapiens_hsa045300.44364002
101Arachidonic acid metabolism_Homo sapiens_hsa005900.42587068
102HIF-1 signaling pathway_Homo sapiens_hsa040660.42029714
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.41937434
104T cell receptor signaling pathway_Homo sapiens_hsa046600.41850324
105Focal adhesion_Homo sapiens_hsa045100.39998114
106Prostate cancer_Homo sapiens_hsa052150.39940440
107Influenza A_Homo sapiens_hsa051640.39172338
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.39055601
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.38878219
110Purine metabolism_Homo sapiens_hsa002300.38407348
111Hepatitis B_Homo sapiens_hsa051610.37359758
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32809400
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.32441585
114Shigellosis_Homo sapiens_hsa051310.31955572
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30941446
116Arginine biosynthesis_Homo sapiens_hsa002200.30684560
117Glucagon signaling pathway_Homo sapiens_hsa049220.30628421
118Primary immunodeficiency_Homo sapiens_hsa053400.30305329
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29622670
120Renin-angiotensin system_Homo sapiens_hsa046140.29521302
121Toxoplasmosis_Homo sapiens_hsa051450.28965375
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28675773
123Choline metabolism in cancer_Homo sapiens_hsa052310.28675493
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28539245

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