NUP210

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.74126862
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.38593345
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.38593345
4regulation of gamma-delta T cell differentiation (GO:0045586)4.92438619
5antigen processing and presentation of endogenous antigen (GO:0019883)4.78001282
6DNA unwinding involved in DNA replication (GO:0006268)4.59857539
7regulation of gamma-delta T cell activation (GO:0046643)4.37495952
8negative regulation of erythrocyte differentiation (GO:0045647)4.32041811
9negative T cell selection (GO:0043383)4.26608222
10regulation of histone H3-K27 methylation (GO:0061085)4.24510234
11negative thymic T cell selection (GO:0045060)4.20443817
12dosage compensation (GO:0007549)4.14879249
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.11713963
14positive regulation of B cell differentiation (GO:0045579)3.98521043
15positive thymic T cell selection (GO:0045059)3.96284251
16response to interleukin-15 (GO:0070672)3.84072232
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.80013677
18negative regulation of cell killing (GO:0031342)3.80013677
19nuclear pore complex assembly (GO:0051292)3.75303964
20protein localization to kinetochore (GO:0034501)3.71443383
21B cell receptor signaling pathway (GO:0050853)3.67283698
22thymic T cell selection (GO:0045061)3.59669084
23ribosomal small subunit assembly (GO:0000028)3.54048366
24T cell selection (GO:0045058)3.53227198
25positive T cell selection (GO:0043368)3.49695036
26regulation of B cell differentiation (GO:0045577)3.49352185
27T cell homeostasis (GO:0043029)3.47185237
28negative regulation of phagocytosis (GO:0050765)3.46184627
29V(D)J recombination (GO:0033151)3.42303822
30regulation of histone H3-K9 methylation (GO:0051570)3.39501083
31interferon-gamma production (GO:0032609)3.38095823
32spliceosomal tri-snRNP complex assembly (GO:0000244)3.36063656
33DNA strand elongation involved in DNA replication (GO:0006271)3.34741697
34nuclear pore organization (GO:0006999)3.33779955
35histone H3-K36 demethylation (GO:0070544)3.31525392
36regulation of B cell receptor signaling pathway (GO:0050855)3.28901534
37T cell migration (GO:0072678)3.26160714
38regulation of translational fidelity (GO:0006450)3.25129261
39DNA strand elongation (GO:0022616)3.22487924
40telomere maintenance via semi-conservative replication (GO:0032201)3.18595908
41positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.18205582
42protein localization to chromosome, centromeric region (GO:0071459)3.17057366
43regulation of RNA export from nucleus (GO:0046831)3.16551087
44DNA topological change (GO:0006265)3.15903315
45DNA duplex unwinding (GO:0032508)3.15315732
46negative regulation of histone methylation (GO:0031061)3.14869903
47mitotic sister chromatid cohesion (GO:0007064)3.12964942
48cellular response to interleukin-15 (GO:0071350)3.11875595
49DNA geometric change (GO:0032392)3.10882906
50negative regulation of RNA splicing (GO:0033119)3.09180114
51DNA replication initiation (GO:0006270)3.08931941
52Peyers patch development (GO:0048541)3.06223113
53mucosal-associated lymphoid tissue development (GO:0048537)3.06223113
54sister chromatid segregation (GO:0000819)3.04914626
55mitotic chromosome condensation (GO:0007076)3.01805717
56positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.01528010
57negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00922050
58leukocyte aggregation (GO:0070486)3.00813513
59tolerance induction (GO:0002507)2.98457685
60antigen receptor-mediated signaling pathway (GO:0050851)2.97677833
61pore complex assembly (GO:0046931)2.94865217
62positive regulation of histone deacetylation (GO:0031065)2.93245412
63lymphocyte homeostasis (GO:0002260)2.93099230
64translesion synthesis (GO:0019985)2.93060602
65T cell receptor signaling pathway (GO:0050852)2.90309438
66mitotic recombination (GO:0006312)2.88019422
67viral transcription (GO:0019083)2.87442057
68alternative mRNA splicing, via spliceosome (GO:0000380)2.86735852
69mannose metabolic process (GO:0006013)2.85883400
70mRNA stabilization (GO:0048255)2.82332179
71RNA stabilization (GO:0043489)2.82332179
72telomere maintenance via recombination (GO:0000722)2.81817595
73regulation of chromatin binding (GO:0035561)2.81707867
74response to muramyl dipeptide (GO:0032495)2.79767404
75mitotic sister chromatid segregation (GO:0000070)2.79416896
76regulation of interleukin-12 biosynthetic process (GO:0045075)2.78975122
77T cell costimulation (GO:0031295)2.78885987
78translational termination (GO:0006415)2.75410126
79natural killer cell differentiation (GO:0001779)2.74309430
80lymphocyte costimulation (GO:0031294)2.73878938
81regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.73070815
82positive regulation of isotype switching (GO:0045830)2.71962574
83DNA synthesis involved in DNA repair (GO:0000731)2.70499729
84histone mRNA catabolic process (GO:0071044)2.70435592
85proline biosynthetic process (GO:0006561)2.68758296
863-UTR-mediated mRNA stabilization (GO:0070935)2.68752314
87* mitotic nuclear envelope disassembly (GO:0007077)2.68629884
88regulation of histone methylation (GO:0031060)2.68259096
89positive regulation of interleukin-2 production (GO:0032743)2.68023283
90positive regulation of histone H3-K4 methylation (GO:0051571)2.66854770
91regulation of nucleobase-containing compound transport (GO:0032239)2.66453014
92mast cell activation (GO:0045576)2.66230503
93regulation of histone H3-K4 methylation (GO:0051569)2.66181971
94leukocyte homeostasis (GO:0001776)2.64416127
95antigen processing and presentation via MHC class Ib (GO:0002475)2.64352157
96regulation of granulocyte differentiation (GO:0030852)2.64218257
97folic acid-containing compound biosynthetic process (GO:0009396)2.63838028
98regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63584138
99cellular response to interleukin-4 (GO:0071353)2.63232471
100positive regulation of granulocyte differentiation (GO:0030854)2.63153491
101regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.62634460
102response to interleukin-4 (GO:0070670)2.62100281
103gonadal mesoderm development (GO:0007506)2.61648052
104histone H3-K4 methylation (GO:0051568)2.61233137
105poly(A)+ mRNA export from nucleus (GO:0016973)2.61228178
106Arp2/3 complex-mediated actin nucleation (GO:0034314)2.61005067
107negative regulation of mRNA processing (GO:0050686)2.60403480
108chromosome condensation (GO:0030261)2.59758895
109regulation of alpha-beta T cell proliferation (GO:0046640)2.58865077
110regulation of DNA endoreduplication (GO:0032875)2.58839096
111intracellular estrogen receptor signaling pathway (GO:0030520)2.57689089
112regulation of T cell receptor signaling pathway (GO:0050856)2.57300708
113IMP biosynthetic process (GO:0006188)2.56875792
114positive regulation of gene expression, epigenetic (GO:0045815)2.56303371
115nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.55812981
116regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.55194218
117modulation by virus of host process (GO:0019054)2.54166473
118DNA conformation change (GO:0071103)2.54096054
119nucleosome disassembly (GO:0006337)2.53774300
120protein-DNA complex disassembly (GO:0032986)2.53774300
121nucleotide-excision repair, DNA gap filling (GO:0006297)2.53742014
122T cell lineage commitment (GO:0002360)2.53718462
123somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.52968136
124somatic cell DNA recombination (GO:0016444)2.52968136
125positive regulation of protein deacetylation (GO:0090312)2.52566917
126regulation of interleukin-2 biosynthetic process (GO:0045076)2.52483864
127megakaryocyte development (GO:0035855)2.51785480
128antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.51575638
129glucocorticoid receptor signaling pathway (GO:0042921)2.51540355
130modulation by symbiont of host immune response (GO:0052553)2.51424604
131positive regulation by symbiont of host defense response (GO:0052509)2.51424604
132modulation by symbiont of host defense response (GO:0052031)2.51424604
133modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.51424604
134modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.51424604
135positive regulation by organism of defense response of other organism involved in symbiotic interact2.51424604
136negative regulation of mRNA metabolic process (GO:1903312)2.50840968
137B cell homeostasis (GO:0001782)2.48175774
138histone H3-K4 trimethylation (GO:0080182)2.47960507
139regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46665925
140protein export from nucleus (GO:0006611)2.45943668
141CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.44284782
142ribosomal small subunit biogenesis (GO:0042274)2.43239832
143formation of translation preinitiation complex (GO:0001731)2.43101248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.98645167
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.16954473
3* MYC_22102868_ChIP-Seq_BL_Human3.94534590
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.32281391
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.28632449
6* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.17844670
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.16928321
8VDR_21846776_ChIP-Seq_THP-1_Human2.82245818
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77334637
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.54544056
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.49720129
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.46949563
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41286242
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.32707605
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25115237
16MYB_26560356_Chip-Seq_TH2_Human2.22837774
17SCL_19346495_ChIP-Seq_HPC-7_Human2.20330552
18CIITA_25753668_ChIP-Seq_RAJI_Human2.19160211
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.15950899
20MAF_26560356_Chip-Seq_TH1_Human2.13716487
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06766607
22* MYB_26560356_Chip-Seq_TH1_Human2.05867313
23* UTX_26944678_Chip-Seq_JUKART_Human2.04398927
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03873778
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00611393
26TCF7_22412390_ChIP-Seq_EML_Mouse1.97036424
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92029949
28* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.89360171
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88829785
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.86435033
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86337353
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83463606
33RUNX_20019798_ChIP-Seq_JUKART_Human1.82738320
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82419714
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76032620
36* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70880497
37* VDR_24763502_ChIP-Seq_THP-1_Human1.69189495
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68347710
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.68043713
40SPI1_23547873_ChIP-Seq_NB4_Human1.67370528
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.66796068
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57367983
43LXR_22292898_ChIP-Seq_THP-1_Human1.56826189
44FOXP3_21729870_ChIP-Seq_TREG_Human1.56491663
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55579466
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51160571
47MAF_26560356_Chip-Seq_TH2_Human1.50526118
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49793093
49VDR_23849224_ChIP-Seq_CD4+_Human1.49609174
50XRN2_22483619_ChIP-Seq_HELA_Human1.49179172
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.48299684
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48137716
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48040356
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47907007
55KDM2B_26808549_Chip-Seq_DND41_Human1.43264341
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39477955
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38345665
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36410020
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33612553
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32584041
61CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32135884
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29974512
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29777233
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29710019
65GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26850362
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.26589418
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26103234
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.25378957
69KDM5A_27292631_Chip-Seq_BREAST_Human1.25074653
70SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24788740
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23153028
72GATA3_27048872_Chip-Seq_THYMUS_Human1.21208759
73RACK7_27058665_Chip-Seq_MCF-7_Human1.19730283
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18180437
75* KDM2B_26808549_Chip-Seq_JURKAT_Human1.17941931
76NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17067206
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.15690384
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14218591
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13700526
80KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13679279
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13138779
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11349331
83* SPI1_23127762_ChIP-Seq_K562_Human1.09661898
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08588876
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.07710480
86P68_20966046_ChIP-Seq_HELA_Human1.06656896
87GATA1_22025678_ChIP-Seq_K562_Human1.06195601
88ZNF263_19887448_ChIP-Seq_K562_Human1.05892463
89* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05328690
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04413543
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03245216
92ETS1_20019798_ChIP-Seq_JURKAT_Human1.03181875
93* TFEB_21752829_ChIP-Seq_HELA_Human1.02286228
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.00918616
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00488323
96AR_21909140_ChIP-Seq_LNCAP_Human1.00038665
97CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99909690
98* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99660470
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99596202
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99545857
101* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98696528
102STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98180816
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97170919
104EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96022538
105PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95251616
106GABP_19822575_ChIP-Seq_HepG2_Human0.94601618
107NCOR1_26117541_ChIP-Seq_K562_Human0.94550337
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93687059
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93646447
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93299708
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93147207
112ELK1_19687146_ChIP-ChIP_HELA_Human0.92459141
113LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92424254
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91761558
115* ELF1_20517297_ChIP-Seq_JURKAT_Human0.91581281
116CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91489974
117TTF2_22483619_ChIP-Seq_HELA_Human0.91040029
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90392220
119POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87928458
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87635164
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86929773
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.86613819
123DCP1A_22483619_ChIP-Seq_HELA_Human0.85842500

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.72674532
2MP0002396_abnormal_hematopoietic_system3.70967779
3MP0008057_abnormal_DNA_replication3.27677866
4MP0000685_abnormal_immune_system3.02036876
5MP0010094_abnormal_chromosome_stability3.00354566
6MP0001835_abnormal_antigen_presentation2.97787551
7MP0001800_abnormal_humoral_immune2.94131245
8MP0002398_abnormal_bone_marrow2.80118747
9MP0005671_abnormal_response_to2.79192206
10MP0004808_abnormal_hematopoietic_stem2.63028924
11MP0005451_abnormal_body_composition2.51639822
12MP0003111_abnormal_nucleus_morphology2.48695025
13MP0000703_abnormal_thymus_morphology2.46487550
14MP0003693_abnormal_embryo_hatching2.45969693
15MP0005387_immune_system_phenotype2.44647607
16MP0001790_abnormal_immune_system2.44647607
17MP0002420_abnormal_adaptive_immunity2.38163412
18MP0003077_abnormal_cell_cycle2.35650648
19MP0001819_abnormal_immune_cell2.33593499
20MP0002452_abnormal_antigen_presenting2.31622623
21MP0000689_abnormal_spleen_morphology2.29990162
22MP0002722_abnormal_immune_system2.28815556
23MP0002166_altered_tumor_susceptibility2.27166485
24MP0000716_abnormal_immune_system2.27114322
25MP0003300_gastrointestinal_ulcer2.25900719
26MP0002723_abnormal_immune_serum2.25759239
27MP0005000_abnormal_immune_tolerance2.08328809
28MP0010352_gastrointestinal_tract_polyps2.04992096
29MP0002429_abnormal_blood_cell2.01860662
30MP0001545_abnormal_hematopoietic_system1.99412375
31MP0005397_hematopoietic_system_phenotyp1.99412375
32MP0009333_abnormal_splenocyte_physiolog1.99031095
33MP0004957_abnormal_blastocyst_morpholog1.96416823
34MP0003866_abnormal_defecation1.94500940
35MP0003436_decreased_susceptibility_to1.93980839
36MP0000490_abnormal_crypts_of1.90278432
37MP0001873_stomach_inflammation1.89240995
38MP0003303_peritoneal_inflammation1.87809919
39MP0005025_abnormal_response_to1.87698034
40MP0009278_abnormal_bone_marrow1.86542182
41MP0002405_respiratory_system_inflammati1.83483426
42MP0004185_abnormal_adipocyte_glucose1.83307984
43MP0002006_tumorigenesis1.79769967
44MP0010155_abnormal_intestine_physiology1.79665675
45MP0005464_abnormal_platelet_physiology1.75472596
46MP0009785_altered_susceptibility_to1.69343270
47MP0004381_abnormal_hair_follicle1.63626986
48MP0010307_abnormal_tumor_latency1.62642254
49MP0008058_abnormal_DNA_repair1.62307775
50MP0002019_abnormal_tumor_incidence1.58886139
51MP0008007_abnormal_cellular_replicative1.54688250
52MP0000465_gastrointestinal_hemorrhage1.45036502
53MP0002419_abnormal_innate_immunity1.42718053
54MP0008260_abnormal_autophagy1.39436721
55MP0000350_abnormal_cell_proliferation1.38673187
56MP0001853_heart_inflammation1.34207206
57MP0004947_skin_inflammation1.33569328
58MP0005076_abnormal_cell_differentiation1.32982310
59MP0001730_embryonic_growth_arrest1.28822187
60MP0001845_abnormal_inflammatory_respons1.28553021
61MP0005058_abnormal_lysosome_morphology1.28086709
62MP0005174_abnormal_tail_pigmentation1.27314980
63MP0008877_abnormal_DNA_methylation1.26180720
64MP0004264_abnormal_extraembryonic_tissu1.26174580
65MP0005075_abnormal_melanosome_morpholog1.23345156
66MP0002148_abnormal_hypersensitivity_rea1.18882932
67MP0000313_abnormal_cell_death1.17254657
68MP0003787_abnormal_imprinting1.14494095
69MP0009672_abnormal_birth_weight1.12320914
70MP0000858_altered_metastatic_potential1.09079083
71MP0008961_abnormal_basal_metabolism1.04763652
72MP0004233_abnormal_muscle_weight1.01991830
73MP0008995_early_reproductive_senescence0.99471365
74MP0006082_CNS_inflammation0.96951699
75MP0002095_abnormal_skin_pigmentation0.96943091
76MP0001348_abnormal_lacrimal_gland0.96508984
77MP0002933_joint_inflammation0.93064700
78MP0001661_extended_life_span0.92956758
79MP0003705_abnormal_hypodermis_morpholog0.91868692
80MP0005666_abnormal_adipose_tissue0.90659871
81MP0002086_abnormal_extraembryonic_tissu0.90025991
82MP0002080_prenatal_lethality0.89660666
83MP0006054_spinal_hemorrhage0.89505586
84MP0003984_embryonic_growth_retardation0.88413208
85MP0010234_abnormal_vibrissa_follicle0.88363914
86MP0001672_abnormal_embryogenesis/_devel0.88193227
87MP0005380_embryogenesis_phenotype0.88193227
88MP0002088_abnormal_embryonic_growth/wei0.85561886
89MP0001697_abnormal_embryo_size0.85515817
90MP0005310_abnormal_salivary_gland0.84182058
91MP0001851_eye_inflammation0.82216912
92MP0003221_abnormal_cardiomyocyte_apopto0.78614081
93MP0003448_altered_tumor_morphology0.78182066
94MP0005384_cellular_phenotype0.77205272
95MP0003786_premature_aging0.76582080
96MP0004197_abnormal_fetal_growth/weight/0.76169999
97MP0003943_abnormal_hepatobiliary_system0.76012202
98MP0002970_abnormal_white_adipose0.75846505
99MP0000609_abnormal_liver_physiology0.74706598
100MP0000477_abnormal_intestine_morphology0.73959967
101MP0002138_abnormal_hepatobiliary_system0.73748900
102MP0005220_abnormal_exocrine_pancreas0.72884131
103MP0000371_diluted_coat_color0.72603110
104MP0008469_abnormal_protein_level0.72351019
105MP0000598_abnormal_liver_morphology0.71601374
106MP0000015_abnormal_ear_pigmentation0.71165786
107MP0009931_abnormal_skin_appearance0.70820805
108MP0003656_abnormal_erythrocyte_physiolo0.69513909
109MP0002009_preneoplasia0.68069307
110MP0003183_abnormal_peptide_metabolism0.67857409
111MP0005621_abnormal_cell_physiology0.64446726
112MP0002877_abnormal_melanocyte_morpholog0.63881223
113MP0005501_abnormal_skin_physiology0.62292410
114MP0003121_genomic_imprinting0.61150982
115MP0004510_myositis0.60493440
116MP0003172_abnormal_lysosome_physiology0.59974002
117MP0008932_abnormal_embryonic_tissue0.59694099
118MP0002928_abnormal_bile_duct0.59487042
119MP0001663_abnormal_digestive_system0.57680939
120MP0002075_abnormal_coat/hair_pigmentati0.57445874
121MP0002132_abnormal_respiratory_system0.56435201
122MP0008770_decreased_survivor_rate0.56238377
123MP0002084_abnormal_developmental_patter0.55761176

Predicted human phenotypes

RankGene SetZ-score
1Panhypogammaglobulinemia (HP:0003139)4.55337198
2Recurrent viral infections (HP:0004429)4.54147533
3T lymphocytopenia (HP:0005403)4.47369532
4Agammaglobulinemia (HP:0004432)4.29364730
5IgM deficiency (HP:0002850)4.20977773
6Abnormality of the fingertips (HP:0001211)4.19217364
7Abnormality of T cell number (HP:0011839)4.16388808
8Chronic otitis media (HP:0000389)4.15141385
9Recurrent bronchitis (HP:0002837)4.12101400
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.05320360
11Recurrent fungal infections (HP:0002841)3.83618987
12Abnormality of B cell number (HP:0010975)3.81932879
13B lymphocytopenia (HP:0010976)3.81932879
14Abnormality of T cells (HP:0002843)3.81476433
15Cellulitis (HP:0100658)3.74970334
16Papilloma (HP:0012740)3.66388895
17Verrucae (HP:0200043)3.66388895
18Thrombocytosis (HP:0001894)3.38512498
19Meningitis (HP:0001287)3.33542779
20Thyroiditis (HP:0100646)3.33523024
21Severe combined immunodeficiency (HP:0004430)3.29716033
22Combined immunodeficiency (HP:0005387)3.26757001
23Gastrointestinal inflammation (HP:0004386)3.19429421
24Abnormality of T cell physiology (HP:0011840)3.12531208
25Inflammation of the large intestine (HP:0002037)3.09665155
26Recurrent cutaneous fungal infections (HP:0011370)3.08340216
27Chronic mucocutaneous candidiasis (HP:0002728)3.08340216
28Chromosomal breakage induced by crosslinking agents (HP:0003221)3.00763865
29Nasal polyposis (HP:0100582)2.93444309
30Basal cell carcinoma (HP:0002671)2.85151849
31Colitis (HP:0002583)2.84127609
32Viral hepatitis (HP:0006562)2.83433466
33Volvulus (HP:0002580)2.82671446
34Lymphopenia (HP:0001888)2.81936228
35Abnormality of cells of the lymphoid lineage (HP:0012140)2.77820715
36IgG deficiency (HP:0004315)2.74325571
37Elevated erythrocyte sedimentation rate (HP:0003565)2.73678339
38Hypoplasia of the thymus (HP:0000778)2.68912072
39Lymphoma (HP:0002665)2.64849513
40Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.55102900
41Eosinophilia (HP:0001880)2.53540795
42Chronic sinusitis (HP:0011109)2.52680687
43Seborrheic dermatitis (HP:0001051)2.51880098
44Reticulocytosis (HP:0001923)2.42206874
45Prolonged bleeding time (HP:0003010)2.42182835
46Spontaneous hematomas (HP:0007420)2.41393537
47Abnormality of the nasal mucosa (HP:0000433)2.40615455
48Abnormal number of erythroid precursors (HP:0012131)2.39188314
49Cholecystitis (HP:0001082)2.39053191
50Abnormal gallbladder physiology (HP:0012438)2.39053191
51Reticulocytopenia (HP:0001896)2.38148862
52IgA deficiency (HP:0002720)2.37994382
53Granulocytopenia (HP:0001913)2.37384526
54Abnormality of cells of the erythroid lineage (HP:0012130)2.37347222
55Recurrent sinusitis (HP:0011108)2.36904635
56Abnormality of eosinophils (HP:0001879)2.35724960
57Autoimmune hemolytic anemia (HP:0001890)2.34780588
58Fatigue (HP:0012378)2.32902241
59Prominent nose (HP:0000448)2.32279223
60Osteomyelitis (HP:0002754)2.31694902
61Myelodysplasia (HP:0002863)2.31086507
62Eczematoid dermatitis (HP:0000976)2.28070289
63Acute lymphatic leukemia (HP:0006721)2.27260919
64Autoimmune thrombocytopenia (HP:0001973)2.26376896
65Pustule (HP:0200039)2.25265041
66Papilledema (HP:0001085)2.24811975
67Bronchitis (HP:0012387)2.24672086
68Progressive external ophthalmoplegia (HP:0000590)2.24574899
69Hyperacusis (HP:0010780)2.23996642
70Myositis (HP:0100614)2.23957273
71Dysmetric saccades (HP:0000641)2.23789924
72Poikiloderma (HP:0001029)2.23188643
73Deep palmar crease (HP:0006191)2.22905347
74Abnormality of reticulocytes (HP:0004312)2.21570309
75Amaurosis fugax (HP:0100576)2.20911933
76Leukocytosis (HP:0001974)2.17555923
77Long eyelashes (HP:0000527)2.16404920
78Encephalitis (HP:0002383)2.15328875
79Abnormality of the thoracic spine (HP:0100711)2.12808606
80Microvesicular hepatic steatosis (HP:0001414)2.12794406
81Birth length less than 3rd percentile (HP:0003561)2.11161050
82Chest pain (HP:0100749)2.10743876
83Abnormal platelet volume (HP:0011876)2.10709985
84Increased IgE level (HP:0003212)2.09996325
85Petechiae (HP:0000967)2.09568427
86Recurrent abscess formation (HP:0002722)2.08396501
87Aplasia/Hypoplasia of the thymus (HP:0010515)2.08281215
88Chromsome breakage (HP:0040012)2.08195996
89Hypertensive crisis (HP:0100735)2.07517346
90Cutis marmorata (HP:0000965)2.07289345
91Increased density of long bones (HP:0006392)2.06990519
92Slow saccadic eye movements (HP:0000514)2.05827182
93Acute myeloid leukemia (HP:0004808)2.04203326
94Overlapping toe (HP:0001845)2.04180643
95Hepatitis (HP:0012115)2.04052009
96Broad face (HP:0000283)2.03273650
97Progressive muscle weakness (HP:0003323)2.03112592
98Vasculitis (HP:0002633)2.02903964
99Hypochromic anemia (HP:0001931)2.02877358
100Mediastinal lymphadenopathy (HP:0100721)2.02113147
101Epistaxis (HP:0000421)2.01419754
102High pitched voice (HP:0001620)2.00425449
103Recurrent skin infections (HP:0001581)2.00339840
104Thoracic kyphosis (HP:0002942)1.99888961
105Abnormality of macrophages (HP:0004311)1.98086127
106Ankyloglossia (HP:0010296)1.95475211
107Cafe-au-lait spot (HP:0000957)1.95369087
108Chronic diarrhea (HP:0002028)1.95057320
109Sepsis (HP:0100806)1.94173691
110Cutaneous melanoma (HP:0012056)1.92996263
111Heterotopia (HP:0002282)1.91931046
112Abnormality of the prostate (HP:0008775)1.91634418
113Abnormality of the intervertebral disk (HP:0005108)1.88819842
114Abnormality of chromosome stability (HP:0003220)1.88448180
115Chronic obstructive pulmonary disease (HP:0006510)1.88367841
116Obstructive lung disease (HP:0006536)1.88367841
117Asymmetry of the thorax (HP:0001555)1.88085220
118Recurrent bacterial skin infections (HP:0005406)1.87908214
119Abnormality of the thymus (HP:0000777)1.86353475
120Metaphyseal cupping (HP:0003021)1.85099681
121Subacute progressive viral hepatitis (HP:0006572)1.83899678
122Recurrent otitis media (HP:0000403)1.83336143
123Leukopenia (HP:0001882)1.82477068
124Abnormality of the columella (HP:0009929)1.82159519
125Micronodular cirrhosis (HP:0001413)1.81312803
126Abnormality of oral frenula (HP:0000190)1.80237200
127Squamous cell carcinoma (HP:0002860)1.80150741
128Gastrointestinal stroma tumor (HP:0100723)1.80101826
129Periodontitis (HP:0000704)1.78953590
130Gastrointestinal infarctions (HP:0005244)1.78722145
131Deep philtrum (HP:0002002)1.78286314
132Abnormality of DNA repair (HP:0003254)1.77811784
133Ependymoma (HP:0002888)1.77460416
134Medulloblastoma (HP:0002885)1.77377563
135Skin ulcer (HP:0200042)1.77313321
13611 pairs of ribs (HP:0000878)1.77068610
137Abnormality of small intestinal villus morphology (HP:0011472)1.74696048
138Villous atrophy (HP:0011473)1.74696048
139Long palpebral fissure (HP:0000637)1.73320484
140Acute hepatic failure (HP:0006554)1.73096201
141Bowel incontinence (HP:0002607)1.72154806
142Sandal gap (HP:0001852)1.71385888
143Pallor (HP:0000980)1.71034911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.85786951
2EEF2K4.39116637
3PRPF4B3.98049025
4MAP3K103.84027342
5SMG13.63332530
6RIPK42.73037086
7CDC72.64586667
8ICK2.62922208
9GRK62.56007934
10CDK122.48298157
11PKN22.29616992
12STK102.27188318
13TXK2.24663511
14JAK32.20491928
15BTK1.94109402
16ITK1.92895147
17NEK21.87078383
18NME21.86802844
19ZAP701.84773410
20TRIB31.60715355
21SIK11.58918185
22SYK1.58527024
23CLK11.58186719
24TYK21.54901418
25RPS6KB21.51008608
26CDK41.47429292
27PASK1.47201715
28FGFR41.41944159
29PIM11.35569077
30TEC1.33914173
31IRAK31.33695529
32SIK21.33359965
33FGFR31.27161030
34CSF1R1.27109517
35MAP2K31.24007765
36FLT31.23491965
37STK41.22211063
38BRD41.20526217
39LCK1.19259141
40LRRK21.18683016
41ATR1.17947142
42KSR21.09881818
43HCK1.09089837
44JAK11.01164661
45KIT1.00785165
46BLK0.99086351
47SCYL20.97762505
48MAP3K140.97318463
49ALK0.96708517
50ERN10.96133111
51TAOK30.93967277
52TSSK60.93177626
53FES0.92175177
54CSK0.92006683
55WEE10.91295961
56SRPK10.89659489
57NLK0.89458464
58HIPK20.89022606
59MAP3K80.87783570
60RPS6KA40.85293656
61IKBKE0.84755560
62CHEK10.80815697
63CDK60.79708780
64TLK10.77778729
65LYN0.77715491
66TESK20.77427923
67MAP2K20.75619731
68MARK20.74395650
69TGFBR10.74039928
70CDK70.73262902
71TAOK20.72909894
72CAMK1D0.72590391
73MARK30.69483187
74MAPK110.68699737
75CHUK0.68072762
76MAP3K70.67949305
77TNK20.66947389
78JAK20.66555536
79AURKB0.66520602
80PDK10.66299302
81TBK10.65162762
82MAP3K10.63352595
83IRAK40.62942235
84IKBKB0.62313528
85BUB10.61226176
86CDK90.61090372
87ATM0.58504963
88MELK0.57276309
89CDK20.57260372
90PDPK10.56349450
91PTK60.55564105
92MAPK120.55054015
93RAF10.54614046
94EPHB10.53984128
95IRAK20.53526194
96CDK80.50192297
97MAP3K130.49917557
98MAPK40.49363994
99PRKCQ0.48482949
100RET0.47587559
101TAF10.47504806
102CAMKK10.46099347
103TTK0.45995570
104CHEK20.43695247
105CDC42BPA0.42964620
106MTOR0.41247421
107PRKCH0.41205619
108DYRK30.40751589
109* CDK10.40478892
110TTN0.40475964
111RPS6KB10.40069927
112TRPM70.39831819
113YES10.39257253
114PLK10.39241912
115RPS6KA60.38032664
116BRAF0.37393244
117VRK10.36226606
118SIK30.34300773
119RPS6KC10.34130440
120RPS6KL10.34130440
121TAOK10.33586295
122EIF2AK30.32898468
123BRSK10.32053061
124EIF2AK10.31943632
125MAPKAPK20.31923959
126MAPK30.31116965

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.24103341
2DNA replication_Homo sapiens_hsa030303.61764438
3Mismatch repair_Homo sapiens_hsa034302.79873870
4Base excision repair_Homo sapiens_hsa034102.51009063
5B cell receptor signaling pathway_Homo sapiens_hsa046622.49621051
6Non-homologous end-joining_Homo sapiens_hsa034502.28055439
7T cell receptor signaling pathway_Homo sapiens_hsa046602.12556137
8Spliceosome_Homo sapiens_hsa030402.04574013
9Antigen processing and presentation_Homo sapiens_hsa046121.98930468
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.98267208
11Measles_Homo sapiens_hsa051621.90803871
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.88621714
13Cell cycle_Homo sapiens_hsa041101.85809766
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.72283121
15Homologous recombination_Homo sapiens_hsa034401.69404160
16One carbon pool by folate_Homo sapiens_hsa006701.68951972
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68101294
18Ribosome_Homo sapiens_hsa030101.66027445
19Herpes simplex infection_Homo sapiens_hsa051681.61118193
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57596445
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56735273
22Other glycan degradation_Homo sapiens_hsa005111.55368050
23* RNA transport_Homo sapiens_hsa030131.54603918
24Leishmaniasis_Homo sapiens_hsa051401.53221332
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51461159
26mRNA surveillance pathway_Homo sapiens_hsa030151.50328044
27Hematopoietic cell lineage_Homo sapiens_hsa046401.48075459
28Acute myeloid leukemia_Homo sapiens_hsa052211.45718959
29Chronic myeloid leukemia_Homo sapiens_hsa052201.45604289
30Osteoclast differentiation_Homo sapiens_hsa043801.45318199
31Nucleotide excision repair_Homo sapiens_hsa034201.42278477
32Viral carcinogenesis_Homo sapiens_hsa052031.39157038
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37790536
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33193706
35Fanconi anemia pathway_Homo sapiens_hsa034601.32961865
36Hepatitis B_Homo sapiens_hsa051611.28319572
37Non-small cell lung cancer_Homo sapiens_hsa052231.26147557
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.25556032
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25154786
40Epstein-Barr virus infection_Homo sapiens_hsa051691.20838889
41HTLV-I infection_Homo sapiens_hsa051661.19933545
42Systemic lupus erythematosus_Homo sapiens_hsa053221.19384207
43RNA degradation_Homo sapiens_hsa030181.18142937
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15412533
45p53 signaling pathway_Homo sapiens_hsa041151.11766453
46Viral myocarditis_Homo sapiens_hsa054161.07798415
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04273279
48Pancreatic cancer_Homo sapiens_hsa052121.02306547
49Apoptosis_Homo sapiens_hsa042101.01959868
50Renal cell carcinoma_Homo sapiens_hsa052111.01119197
51Lysine degradation_Homo sapiens_hsa003100.99879198
52Influenza A_Homo sapiens_hsa051640.96422995
53Toxoplasmosis_Homo sapiens_hsa051450.96000968
54Chemokine signaling pathway_Homo sapiens_hsa040620.95580146
55Biosynthesis of amino acids_Homo sapiens_hsa012300.95093817
56Allograft rejection_Homo sapiens_hsa053300.95047470
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94031544
58Colorectal cancer_Homo sapiens_hsa052100.93032060
59Bladder cancer_Homo sapiens_hsa052190.91344843
60Platelet activation_Homo sapiens_hsa046110.88461549
61Small cell lung cancer_Homo sapiens_hsa052220.88408010
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.87989871
63Pyrimidine metabolism_Homo sapiens_hsa002400.85495776
64Shigellosis_Homo sapiens_hsa051310.84259586
65Graft-versus-host disease_Homo sapiens_hsa053320.82027336
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.80463461
67ErbB signaling pathway_Homo sapiens_hsa040120.79855243
68Choline metabolism in cancer_Homo sapiens_hsa052310.79615358
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78771876
70Fructose and mannose metabolism_Homo sapiens_hsa000510.78240736
71MicroRNAs in cancer_Homo sapiens_hsa052060.77933664
72Legionellosis_Homo sapiens_hsa051340.76430028
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73415782
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73077404
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72552357
76Notch signaling pathway_Homo sapiens_hsa043300.72414176
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72335554
78Insulin signaling pathway_Homo sapiens_hsa049100.71480025
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70205144
80mTOR signaling pathway_Homo sapiens_hsa041500.68938695
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68115919
82TNF signaling pathway_Homo sapiens_hsa046680.65665490
83VEGF signaling pathway_Homo sapiens_hsa043700.65615006
84Prolactin signaling pathway_Homo sapiens_hsa049170.62507895
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61401609
86FoxO signaling pathway_Homo sapiens_hsa040680.59450210
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57660453
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57489550
89Thyroid cancer_Homo sapiens_hsa052160.57341935
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56858757
91N-Glycan biosynthesis_Homo sapiens_hsa005100.55288444
92Tuberculosis_Homo sapiens_hsa051520.55147265
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53620619
94Hepatitis C_Homo sapiens_hsa051600.53599675
95Asthma_Homo sapiens_hsa053100.51651375
96Carbon metabolism_Homo sapiens_hsa012000.50744005
97Type I diabetes mellitus_Homo sapiens_hsa049400.50505741
98Pentose phosphate pathway_Homo sapiens_hsa000300.49659646
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49104353
100Autoimmune thyroid disease_Homo sapiens_hsa053200.48503067
101Prostate cancer_Homo sapiens_hsa052150.46841254
102Alcoholism_Homo sapiens_hsa050340.45606016
103Insulin resistance_Homo sapiens_hsa049310.45531808
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44924374
105HIF-1 signaling pathway_Homo sapiens_hsa040660.44420105
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.43404086
107Endometrial cancer_Homo sapiens_hsa052130.41827118
108Inositol phosphate metabolism_Homo sapiens_hsa005620.41174425
109RNA polymerase_Homo sapiens_hsa030200.39249439
110Selenocompound metabolism_Homo sapiens_hsa004500.38874690
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37681078
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.37671893
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36733738
114Glioma_Homo sapiens_hsa052140.36324368
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34269929

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