ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to lipoprotein particle (GO:0055094)	6.66101802
2	inositol phosphate catabolic process (GO:0071545)	6.19414736
3	inositol phosphate dephosphorylation (GO:0046855)	5.91159872
4	phosphorylated carbohydrate dephosphorylation (GO:0046838)	5.91159872
5	cellular response to hepatocyte growth factor stimulus (GO:0035729)	5.36691436
6	response to hepatocyte growth factor (GO:0035728)	5.36691436
7	cellular response to vitamin D (GO:0071305)	5.29044899
8	chemosensory behavior (GO:0007635)	5.19332878
9	peroxisome fission (GO:0016559)	5.17897086
10	positive regulation of mitochondrial fission (GO:0090141)	5.14340539
11	histone H2A monoubiquitination (GO:0035518)	4.74568812
12	polyol catabolic process (GO:0046174)	4.49304487
13	cellular response to vitamin (GO:0071295)	4.39265118
14	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	4.34807117
15	glucosamine-containing compound catabolic process (GO:1901072)	4.32084233
16	paraxial mesoderm development (GO:0048339)	4.20535431
17	intraciliary transport (GO:0042073)	4.13356559
18	mitochondrial fusion (GO:0008053)	4.09310572
19	establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)	4.04109173
20	ketone body metabolic process (GO:1902224)	4.03005170
21	cellular ketone body metabolic process (GO:0046950)	4.02275335
22	negative regulation of Rho protein signal transduction (GO:0035024)	4.01834956
23	spermatid nucleus differentiation (GO:0007289)	3.95160644
24	forebrain neuron differentiation (GO:0021879)	3.92923922
25	detection of calcium ion (GO:0005513)	3.92667521
26	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.77130790
27	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.77130790
28	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.77130790
29	histone H2A ubiquitination (GO:0033522)	3.75792788
30	ADP metabolic process (GO:0046031)	3.74101907
31	aggressive behavior (GO:0002118)	3.72176046
32	epithelial cilium movement (GO:0003351)	3.70906623
33	mannosylation (GO:0097502)	3.70651201
34	nonmotile primary cilium assembly (GO:0035058)	3.58726836
35	uterus development (GO:0060065)	3.57909067
36	protein localization to cilium (GO:0061512)	3.56023386
37	response to nitrosative stress (GO:0051409)	3.55503176
38	seminiferous tubule development (GO:0072520)	3.53492829
39	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition	3.50734412
40	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.45309797
41	regulation of energy homeostasis (GO:2000505)	3.44793912
42	polarized epithelial cell differentiation (GO:0030859)	3.41212497
43	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	3.38938951
44	DNA methylation involved in gamete generation (GO:0043046)	3.38225129
45	positive regulation of calcium ion import (GO:0090280)	3.37024584
46	regulation of mitochondrial fission (GO:0090140)	3.36819421
47	synaptonemal complex assembly (GO:0007130)	3.35831754
48	nucleoside diphosphate phosphorylation (GO:0006165)	3.29294491
49	peptidyl-arginine methylation (GO:0018216)	3.25163402
50	peptidyl-arginine N-methylation (GO:0035246)	3.25163402
51	potassium ion export (GO:0071435)	3.18572853
52	dendritic spine organization (GO:0097061)	3.13637583
53	negative regulation of neurological system process (GO:0031645)	3.07892165
54	forebrain morphogenesis (GO:0048853)	3.07225658
55	male meiosis (GO:0007140)	3.07168860
56	DNA double-strand break processing (GO:0000729)	3.03267679
57	negative regulation of cell size (GO:0045792)	3.02207842
58	cilium morphogenesis (GO:0060271)	2.99659589
59	presynaptic membrane organization (GO:0097090)	2.98619755
60	synaptonemal complex organization (GO:0070193)	2.95083629
61	establishment of monopolar cell polarity (GO:0061162)	2.94422430
62	establishment or maintenance of monopolar cell polarity (GO:0061339)	2.94422430
63	establishment of apical/basal cell polarity (GO:0035089)	2.93911704
64	coenzyme catabolic process (GO:0009109)	2.93773181
65	piRNA metabolic process (GO:0034587)	2.92339147
66	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	2.90899425
67	axoneme assembly (GO:0035082)	2.89347491
68	cholesterol biosynthetic process (GO:0006695)	2.86693765
69	cilium or flagellum-dependent cell motility (GO:0001539)	2.86623309
70	dendritic spine morphogenesis (GO:0060997)	2.84757365
71	positive regulation of protein targeting to membrane (GO:0090314)	2.84204261
72	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.83475901
73	axon extension involved in axon guidance (GO:0048846)	2.83475901
74	negative regulation of telomere maintenance (GO:0032205)	2.82729254
75	relaxation of smooth muscle (GO:0044557)	2.81749970
76	positive regulation of glycolytic process (GO:0045821)	2.80857085
77	histone H2A acetylation (GO:0043968)	2.80805573
78	protein import into peroxisome matrix (GO:0016558)	2.76926116
79	nitric oxide mediated signal transduction (GO:0007263)	2.76712277
80	vitamin A metabolic process (GO:0006776)	2.75874730
81	regulation of inositol phosphate biosynthetic process (GO:0010919)	2.75315508
82	negative regulation of DNA binding (GO:0043392)	2.75275557
83	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.73993414
84	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.73063134
85	chromosome organization involved in meiosis (GO:0070192)	2.69521456
86	positive regulation of ATP catabolic process (GO:1903291)	2.66966034
87	positive regulation of ATPase activity (GO:0032781)	2.66966034
88	mitotic spindle checkpoint (GO:0071174)	2.66223399
89	sterol biosynthetic process (GO:0016126)	2.65089705
90	cilium movement (GO:0003341)	2.64653017
91	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.63008865
92	cysteine metabolic process (GO:0006534)	2.60645950
93	keratinocyte development (GO:0003334)	2.60349223
94	adenosine metabolic process (GO:0046085)	2.59085205
95	spindle checkpoint (GO:0031577)	2.58574597
96	presynaptic membrane assembly (GO:0097105)	2.58568306
97	central nervous system neuron axonogenesis (GO:0021955)	2.55250067
98	long term synaptic depression (GO:0060292)	2.52234944
99	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.51783560
100	neural tube formation (GO:0001841)	2.51434048

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	6.11112397
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.56152317
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.18014632
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.95396483
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.83064593
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.53485340
7	FUS_26573619_Chip-Seq_HEK293_Human	2.96535683
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.69515680
9	ER_23166858_ChIP-Seq_MCF-7_Human	2.61661501
10	VDR_22108803_ChIP-Seq_LS180_Human	2.44445883
11	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.32414431
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.31424581
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.23631159
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.17477962
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.11415353
16	CBP_20019798_ChIP-Seq_JUKART_Human	2.02880773
17	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.02880773
18	ZNF274_21170338_ChIP-Seq_K562_Hela	1.99797467
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.92297306
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.84658357
21	P300_19829295_ChIP-Seq_ESCs_Human	1.76736391
22	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.67982861
23	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.67132518
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56060025
25	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.53560736
26	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.51522243
27	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.51302356
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51012484
29	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.49992539
30	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.47099661
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45741548
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.44752983
33	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.43153444
34	CDX2_22108803_ChIP-Seq_LS180_Human	1.42696938
35	AR_21572438_ChIP-Seq_LNCaP_Human	1.42509598
36	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41475123
37	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.40672969
38	EZH2_22144423_ChIP-Seq_EOC_Human	1.39543416
39	EWS_26573619_Chip-Seq_HEK293_Human	1.39199175
40	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.35427948
41	CBP_21632823_ChIP-Seq_H3396_Human	1.35238330
42	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.33200254
43	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.32420758
44	STAT3_23295773_ChIP-Seq_U87_Human	1.31737190
45	TCF4_23295773_ChIP-Seq_U87_Human	1.26213584
46	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.25796468
47	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.25796468
48	RXR_22108803_ChIP-Seq_LS180_Human	1.25201728
49	TAF15_26573619_Chip-Seq_HEK293_Human	1.24799953
50	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.24110484
51	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.23792127
52	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22739566
53	SMAD4_21799915_ChIP-Seq_A2780_Human	1.20786115
54	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.19638177
55	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19245040
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.18153077
57	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.16425575
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.16300138
59	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16100020
60	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.14644286
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13613650
62	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.12661840
63	TP53_22573176_ChIP-Seq_HFKS_Human	1.11606861
64	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.10542420
65	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.09891113
66	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.08465503
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07880247
68	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.07281438
69	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.03102733
70	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.02310742
71	NCOR_22424771_ChIP-Seq_293T_Human	1.02169171
72	TBL1_22424771_ChIP-Seq_293T_Human	1.00982603
73	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00501818
74	NFYB_21822215_ChIP-Seq_K562_Human	0.99291488
75	AR_25329375_ChIP-Seq_VCAP_Human	0.97484635
76	AHR_22903824_ChIP-Seq_MCF-7_Human	0.96991584
77	TAF2_19829295_ChIP-Seq_ESCs_Human	0.96645272
78	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.96619409
79	MYC_18940864_ChIP-ChIP_HL60_Human	0.96157679
80	NANOG_19829295_ChIP-Seq_ESCs_Human	0.95753250
81	SOX2_19829295_ChIP-Seq_ESCs_Human	0.95753250
82	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95250641
83	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.95250641
84	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.95106893
85	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.94619469
86	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.94323105
87	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.94075939
88	SOX11_22085726_ChIP-Seq_ESNs_Mouse	0.93939658
89	AR_20517297_ChIP-Seq_VCAP_Human	0.92833644
90	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.87442339
91	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.87046509
92	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.86960581
93	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.86656636
94	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.86596848
95	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.86503689
96	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.86178215
97	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.84103022
98	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.83510040
99	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.83278286
100	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.83025338

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	9.56283027
2	MP0005645_abnormal_hypothalamus_physiol	4.04432410
3	MP0003787_abnormal_imprinting	3.51342257
4	MP0010234_abnormal_vibrissa_follicle	3.50282866
5	MP0003123_paternal_imprinting	3.12221005
6	MP0001984_abnormal_olfaction	2.94964297
7	MP0000678_abnormal_parathyroid_gland	2.89037356
8	MP0002160_abnormal_reproductive_system	2.88268249
9	MP0005647_abnormal_sex_gland	2.85310484
10	MP0003136_yellow_coat_color	2.66653532
11	MP0003283_abnormal_digestive_organ	2.48398504
12	MP0005451_abnormal_body_composition	2.31756426
13	MP0000013_abnormal_adipose_tissue	2.26136646
14	MP0008004_abnormal_stomach_pH	2.08910530
15	MP0002837_dystrophic_cardiac_calcinosis	2.06201536
16	MP0002132_abnormal_respiratory_system	2.03857705
17	MP0004885_abnormal_endolymph	2.03484278
18	MP0008877_abnormal_DNA_methylation	2.00552199
19	MP0009697_abnormal_copulation	1.91986907
20	MP0005389_reproductive_system_phenotype	1.80034564
21	MP0003806_abnormal_nucleotide_metabolis	1.78797240
22	MP0002102_abnormal_ear_morphology	1.76430693
23	MP0000372_irregular_coat_pigmentation	1.64254992
24	MP0001919_abnormal_reproductive_system	1.60964189
25	MP0008058_abnormal_DNA_repair	1.54661424
26	MP0005253_abnormal_eye_physiology	1.47973396
27	MP0001849_ear_inflammation	1.44744992
28	MP0003656_abnormal_erythrocyte_physiolo	1.40789564
29	MP0003315_abnormal_perineum_morphology	1.38948853
30	MP0002108_abnormal_muscle_morphology	1.37350242
31	MP0006072_abnormal_retinal_apoptosis	1.34008352
32	MP0010678_abnormal_skin_adnexa	1.33496696
33	MP0003186_abnormal_redox_activity	1.28498393
34	MP0005187_abnormal_penis_morphology	1.24571413
35	MP0006276_abnormal_autonomic_nervous	1.22685296
36	MP0003122_maternal_imprinting	1.20817852
37	MP0003121_genomic_imprinting	1.20166553
38	MP0000681_abnormal_thyroid_gland	1.17081153
39	MP0004084_abnormal_cardiac_muscle	1.17027715
40	MP0010368_abnormal_lymphatic_system	1.13114774
41	MP0003252_abnormal_bile_duct	1.11685645
42	MP0005379_endocrine/exocrine_gland_phen	1.08230099
43	MP0000778_abnormal_nervous_system	1.06991609
44	MP0005167_abnormal_blood-brain_barrier	1.06569358
45	MP0000516_abnormal_urinary_system	1.06434764
46	MP0005367_renal/urinary_system_phenotyp	1.06434764
47	MP0001529_abnormal_vocalization	1.04610577
48	MP0004484_altered_response_of	1.01907633
49	MP0002163_abnormal_gland_morphology	1.01559442
50	MP0001545_abnormal_hematopoietic_system	0.99714870
51	MP0005397_hematopoietic_system_phenotyp	0.99714870
52	MP0005646_abnormal_pituitary_gland	0.99144319
53	MP0003698_abnormal_male_reproductive	0.98656566
54	MP0000427_abnormal_hair_cycle	0.95949339
55	MP0003011_delayed_dark_adaptation	0.94866987
56	MP0002090_abnormal_vision	0.94127644
57	MP0001929_abnormal_gametogenesis	0.92721987
58	MP0001270_distended_abdomen	0.91744273
59	MP0001661_extended_life_span	0.89479849
60	MP0006036_abnormal_mitochondrial_physio	0.89300171
61	MP0002653_abnormal_ependyma_morphology	0.86846779
62	MP0001145_abnormal_male_reproductive	0.86258602
63	MP0002751_abnormal_autonomic_nervous	0.84689589
64	MP0000653_abnormal_sex_gland	0.83055434
65	MP0008995_early_reproductive_senescence	0.81703606
66	MP0001727_abnormal_embryo_implantation	0.81607323
67	MP0001485_abnormal_pinna_reflex	0.79951036
68	MP0000639_abnormal_adrenal_gland	0.79657856
69	MP0005551_abnormal_eye_electrophysiolog	0.77241827
70	MP0000383_abnormal_hair_follicle	0.75395531
71	MP0000049_abnormal_middle_ear	0.73674021
72	MP0002210_abnormal_sex_determination	0.72957994
73	MP0003890_abnormal_embryonic-extraembry	0.72605645
74	MP0005195_abnormal_posterior_eye	0.70397959
75	MP0000003_abnormal_adipose_tissue	0.70306156
76	MP0008775_abnormal_heart_ventricle	0.70201700
77	MP0001764_abnormal_homeostasis	0.68060810
78	MP0004808_abnormal_hematopoietic_stem	0.64736770
79	MP0004043_abnormal_pH_regulation	0.59785457
80	MP0003880_abnormal_central_pattern	0.59570068
81	MP0005171_absent_coat_pigmentation	0.59188659
82	MP0001486_abnormal_startle_reflex	0.58935132
83	MP0001501_abnormal_sleep_pattern	0.57956948
84	MP0002282_abnormal_trachea_morphology	0.57309494
85	MP0002295_abnormal_pulmonary_circulatio	0.57239696
86	MP0002557_abnormal_social/conspecific_i	0.57075835
87	MP0000538_abnormal_urinary_bladder	0.55975580
88	MP0002752_abnormal_somatic_nervous	0.55637705
89	MP0003937_abnormal_limbs/digits/tail_de	0.54140565
90	MP0005391_vision/eye_phenotype	0.53231871
91	MP0005499_abnormal_olfactory_system	0.53222136
92	MP0005394_taste/olfaction_phenotype	0.53222136
93	MP0000749_muscle_degeneration	0.52715123
94	MP0001119_abnormal_female_reproductive	0.52217584
95	MP0005165_increased_susceptibility_to	0.51301537
96	MP0002168_other_aberrant_phenotype	0.51220490
97	MP0004858_abnormal_nervous_system	0.50399958
98	MP0003718_maternal_effect	0.50223675
99	MP0003936_abnormal_reproductive_system	0.49369708
100	MP0004145_abnormal_muscle_electrophysio	0.49057668

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased circulating renin level (HP:0000848)	7.16960789
2	Hypomagnesemia (HP:0002917)	5.24968379
3	Metaphyseal dysplasia (HP:0100255)	5.12474576
4	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	4.58014809
5	Tetany (HP:0001281)	4.20060055
6	Enlarged penis (HP:0000040)	4.18938296
7	Abnormality of magnesium homeostasis (HP:0004921)	3.89552834
8	Abnormal number of erythroid precursors (HP:0012131)	3.87251341
9	Hepatoblastoma (HP:0002884)	3.70517287
10	Long clavicles (HP:0000890)	3.68209548
11	Polydipsia (HP:0001959)	3.64113730
12	Abnormal drinking behavior (HP:0030082)	3.64113730
13	Abnormal auditory evoked potentials (HP:0006958)	3.42096530
14	Decreased lacrimation (HP:0000633)	3.38164554
15	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.35774507
16	Abnormal protein N-linked glycosylation (HP:0012347)	3.35774507
17	Abnormal protein glycosylation (HP:0012346)	3.35774507
18	Abnormal glycosylation (HP:0012345)	3.35774507
19	Type I transferrin isoform profile (HP:0003642)	3.32423709
20	Tachypnea (HP:0002789)	3.31083827
21	Hyperphosphatemia (HP:0002905)	3.24162720
22	Focal motor seizures (HP:0011153)	3.23495995
23	Neoplasm of the adrenal cortex (HP:0100641)	3.21128938
24	Abnormality of cells of the erythroid lineage (HP:0012130)	3.05395400
25	Facial hemangioma (HP:0000329)	3.01000334
26	Gonadotropin excess (HP:0000837)	2.99677391
27	Adrenal hypoplasia (HP:0000835)	2.90971873
28	Progressive sensorineural hearing impairment (HP:0000408)	2.85195961
29	Congenital primary aphakia (HP:0007707)	2.83554097
30	Abnormality of renin-angiotensin system (HP:0000847)	2.81195665
31	Medial flaring of the eyebrow (HP:0010747)	2.78376798
32	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.77651501
33	Gait imbalance (HP:0002141)	2.74366865
34	Hyperglycinemia (HP:0002154)	2.73393698
35	Macroorchidism (HP:0000053)	2.62176496
36	Reduced antithrombin III activity (HP:0001976)	2.57764630
37	Failure to thrive in infancy (HP:0001531)	2.57584705
38	Hypothermia (HP:0002045)	2.53255138
39	Basal ganglia calcification (HP:0002135)	2.53250912
40	Polyuria (HP:0000103)	2.52244527
41	Pancreatic fibrosis (HP:0100732)	2.46103334
42	Abnormality of the labia minora (HP:0012880)	2.44873404
43	Methylmalonic acidemia (HP:0002912)	2.44074151
44	True hermaphroditism (HP:0010459)	2.42742505
45	Metaphyseal irregularity (HP:0003025)	2.41877773
46	Genital tract atresia (HP:0001827)	2.40653383
47	Nephrogenic diabetes insipidus (HP:0009806)	2.34756944
48	Visual hallucinations (HP:0002367)	2.32296140
49	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.30581886
50	Alacrima (HP:0000522)	2.25522503
51	Delayed CNS myelination (HP:0002188)	2.24914332
52	Nephroblastoma (Wilms tumor) (HP:0002667)	2.24107988
53	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.22883574
54	Increased density of long bones (HP:0006392)	2.19728315
55	Embryonal renal neoplasm (HP:0011794)	2.19608874
56	Abnormal rod and cone electroretinograms (HP:0008323)	2.18850162
57	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.14190507
58	Dyschromatopsia (HP:0007641)	2.12286856
59	Vaginal atresia (HP:0000148)	2.08066855
60	Abnormality of the pubic bones (HP:0003172)	2.07698466
61	Tubulointerstitial nephritis (HP:0001970)	2.07535803
62	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.06491783
63	Poor coordination (HP:0002370)	2.03721707
64	Abnormal urine output (HP:0012590)	1.99967448
65	Broad distal phalanx of finger (HP:0009836)	1.99852236
66	Reticulocytosis (HP:0001923)	1.97786334
67	Postaxial hand polydactyly (HP:0001162)	1.96717580
68	Buphthalmos (HP:0000557)	1.95522612
69	Intestinal atresia (HP:0011100)	1.95472872
70	Germ cell neoplasia (HP:0100728)	1.94661364
71	Hypoplastic pelvis (HP:0008839)	1.93489234
72	Abnormality of the lower motor neuron (HP:0002366)	1.92427956
73	Decreased testicular size (HP:0008734)	1.91726699
74	Conjunctival hamartoma (HP:0100780)	1.90640865
75	Rimmed vacuoles (HP:0003805)	1.89254311
76	Occipital encephalocele (HP:0002085)	1.85723468
77	Abnormality of the pancreatic islet cells (HP:0006476)	1.85653860
78	Abnormality of endocrine pancreas physiology (HP:0012093)	1.85653860
79	Cerebellar dysplasia (HP:0007033)	1.85414339
80	Abnormality of the metopic suture (HP:0005556)	1.83143605
81	Retinal dysplasia (HP:0007973)	1.82439609
82	Embryonal neoplasm (HP:0002898)	1.82136509
83	Chromsome breakage (HP:0040012)	1.80740280
84	Hypoplastic iliac wings (HP:0002866)	1.79517203
85	Febrile seizures (HP:0002373)	1.76890111
86	Ketoacidosis (HP:0001993)	1.76327775
87	Abnormality of DNA repair (HP:0003254)	1.75125067
88	Postaxial foot polydactyly (HP:0001830)	1.74227784
89	Gastrointestinal atresia (HP:0002589)	1.73991865
90	Hypokalemia (HP:0002900)	1.72376032
91	Hamartoma of the eye (HP:0010568)	1.72371917
92	Generalized myoclonic seizures (HP:0002123)	1.72358200
93	Short tibia (HP:0005736)	1.68215072
94	High anterior hairline (HP:0009890)	1.67956593
95	Cystic liver disease (HP:0006706)	1.67341377
96	Narrow forehead (HP:0000341)	1.67203669
97	Poikilocytosis (HP:0004447)	1.66469879
98	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.65341888
99	Abnormality of renal excretion (HP:0011036)	1.64013909
100	Focal seizures (HP:0007359)	1.63598482

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	5.63724378
2	FRK	5.15956778
3	PKN2	5.14968135
4	CLK1	3.95600754
5	LATS1	3.75625858
6	FLT3	3.65964415
7	FGFR2	2.94755220
8	BUB1	2.44048768
9	MAP2K7	2.29246143
10	ERBB3	2.11503506
11	EIF2AK3	1.85928003
12	TAF1	1.78719308
13	NTRK3	1.67657770
14	CSNK1G3	1.66344408
15	BCKDK	1.56123461
16	NUAK1	1.45457671
17	MARK3	1.41881910
18	CSNK1G1	1.41219441
19	DAPK2	1.40488692
20	NEK2	1.36136916
21	CSNK1G2	1.35583041
22	FGFR3	1.34802669
23	TNIK	1.34268379
24	WNK3	1.32992424
25	MAP3K4	1.29504706
26	PLK2	1.22509374
27	CAMKK2	1.20729898
28	GRK5	1.12353566
29	PNCK	1.07728415
30	CSNK1A1L	1.04686185
31	MAP3K6	0.98565750
32	CASK	0.96645027
33	PTK6	0.91109103
34	STK38L	0.90352924
35	PLK1	0.89485747
36	OBSCN	0.88415251
37	CDK9	0.86607631
38	LIMK1	0.85479230
39	PIK3CG	0.85027241
40	FGFR1	0.84755158
41	WEE1	0.84711068
42	TIE1	0.84548008
43	FER	0.83376261
44	STK3	0.82049052
45	MET	0.80919176
46	PTK2B	0.80789973
47	RET	0.79357194
48	PRKG2	0.77102801
49	CAMKK1	0.74587592
50	ZAK	0.73458453
51	NEK1	0.71521661
52	IRAK2	0.71252184
53	MAPK13	0.71196331
54	PIM2	0.69077671
55	PRKD2	0.67017365
56	PAK3	0.65602310
57	TRPM7	0.63864813
58	ADRBK2	0.63829675
59	DYRK3	0.61086086
60	MAPK15	0.60278023
61	VRK2	0.59604669
62	ARAF	0.57858575
63	PRKCG	0.57741519
64	PRKD3	0.55200273
65	FGR	0.49994599
66	BRSK2	0.49461419
67	TNK2	0.49223611
68	AKT2	0.46824845
69	ROCK1	0.44526356
70	DAPK3	0.44317365
71	PRKCE	0.42351846
72	NME2	0.42078500
73	EPHA3	0.41421777
74	MYLK	0.41035707
75	UHMK1	0.40794947
76	BRSK1	0.40532651
77	STK4	0.40489333
78	STK11	0.39879945
79	EGFR	0.39833607
80	IRAK1	0.39065952
81	MARK2	0.38092629
82	MAP2K4	0.37977757
83	PAK6	0.37934645
84	NEK9	0.36567368
85	MAPKAPK5	0.36561144
86	ATM	0.36171931
87	GRK1	0.35064469
88	PRKG1	0.33124122
89	STK39	0.32638727
90	KIT	0.32520417
91	PRKCQ	0.30455538
92	PRKCI	0.27791490
93	CAMK1	0.26556530
94	PLK3	0.26445812
95	EIF2AK2	0.26172259
96	INSRR	0.25741776
97	GSK3A	0.25259900
98	MAP3K5	0.24995045
99	CDK7	0.23421952
100	DYRK2	0.22344504

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.69793366
2	Butanoate metabolism_Homo sapiens_hsa00650	4.34091705
3	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.60422982
4	Regulation of autophagy_Homo sapiens_hsa04140	2.68274921
5	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.58651894
6	Steroid biosynthesis_Homo sapiens_hsa00100	2.41525532
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.33928949
8	Peroxisome_Homo sapiens_hsa04146	2.25683652
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.23070149
10	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.21571789
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.03370286
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.90095541
13	Protein export_Homo sapiens_hsa03060	1.83549494
14	Propanoate metabolism_Homo sapiens_hsa00640	1.75002397
15	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.71297249
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.68310444
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.64186993
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.63000499
19	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.62669438
20	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.60239208
21	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.49847986
22	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.40723738
23	Oocyte meiosis_Homo sapiens_hsa04114	1.35926284
24	Chemical carcinogenesis_Homo sapiens_hsa05204	1.26280289
25	Fatty acid elongation_Homo sapiens_hsa00062	1.20654486
26	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.14382651
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.14301309
28	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.11787736
29	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.10753915
30	Circadian entrainment_Homo sapiens_hsa04713	1.09158040
31	Retinol metabolism_Homo sapiens_hsa00830	1.08816792
32	Phototransduction_Homo sapiens_hsa04744	1.06900884
33	Fatty acid metabolism_Homo sapiens_hsa01212	1.03364478
34	Glutathione metabolism_Homo sapiens_hsa00480	1.02889263
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02109397
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.01982846
37	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.98818213
38	Taste transduction_Homo sapiens_hsa04742	0.98017876
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.96903729
40	Olfactory transduction_Homo sapiens_hsa04740	0.94310645
41	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.92415660
42	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.91321697
43	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.89378041
44	GABAergic synapse_Homo sapiens_hsa04727	0.87169342
45	Renin secretion_Homo sapiens_hsa04924	0.83926307
46	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.81352294
47	Purine metabolism_Homo sapiens_hsa00230	0.79079769
48	Gap junction_Homo sapiens_hsa04540	0.77683766
49	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.76678200
50	ABC transporters_Homo sapiens_hsa02010	0.76236158
51	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.75808700
52	Fatty acid degradation_Homo sapiens_hsa00071	0.75006036
53	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.72479974
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70417141
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68132419
56	Phenylalanine metabolism_Homo sapiens_hsa00360	0.67904639
57	Type II diabetes mellitus_Homo sapiens_hsa04930	0.66868752
58	Tyrosine metabolism_Homo sapiens_hsa00350	0.63684843
59	Glutamatergic synapse_Homo sapiens_hsa04724	0.63011723
60	Salivary secretion_Homo sapiens_hsa04970	0.62815945
61	RNA polymerase_Homo sapiens_hsa03020	0.62422452
62	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.58709955
63	Nucleotide excision repair_Homo sapiens_hsa03420	0.57451767
64	Serotonergic synapse_Homo sapiens_hsa04726	0.57265499
65	Metabolic pathways_Homo sapiens_hsa01100	0.57061949
66	Dopaminergic synapse_Homo sapiens_hsa04728	0.56654585
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56615472
68	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.56254813
69	Wnt signaling pathway_Homo sapiens_hsa04310	0.55651388
70	RNA degradation_Homo sapiens_hsa03018	0.54594856
71	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54435428
72	Nicotine addiction_Homo sapiens_hsa05033	0.52825344
73	mTOR signaling pathway_Homo sapiens_hsa04150	0.52026354
74	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.50020810
75	Basal transcription factors_Homo sapiens_hsa03022	0.49362871
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.48690480
77	Selenocompound metabolism_Homo sapiens_hsa00450	0.46185162
78	RNA transport_Homo sapiens_hsa03013	0.46037114
79	Cocaine addiction_Homo sapiens_hsa05030	0.45385266
80	Homologous recombination_Homo sapiens_hsa03440	0.44162208
81	AMPK signaling pathway_Homo sapiens_hsa04152	0.43356843
82	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.42614063
83	p53 signaling pathway_Homo sapiens_hsa04115	0.42454236
84	Morphine addiction_Homo sapiens_hsa05032	0.41757417
85	Mineral absorption_Homo sapiens_hsa04978	0.41289704
86	Fat digestion and absorption_Homo sapiens_hsa04975	0.38930380
87	Non-homologous end-joining_Homo sapiens_hsa03450	0.38297779
88	mRNA surveillance pathway_Homo sapiens_hsa03015	0.38070453
89	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.37919773
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37206339
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.36585777
92	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.35950764
93	Pyrimidine metabolism_Homo sapiens_hsa00240	0.34572685
94	Axon guidance_Homo sapiens_hsa04360	0.32848593
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.32255962
96	Parkinsons disease_Homo sapiens_hsa05012	0.31627410
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.31426044
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.30618179
99	Insulin secretion_Homo sapiens_hsa04911	0.29534700
100	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.28994605

NUP210P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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