NUP214

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of histone H3-K27 methylation (GO:0061085)6.02544382
2regulation of histone H3-K4 methylation (GO:0051569)5.39622686
3nuclear pore complex assembly (GO:0051292)5.12535158
4negative regulation of erythrocyte differentiation (GO:0045647)5.07423629
5protein localization to kinetochore (GO:0034501)4.84430156
6mitotic chromosome condensation (GO:0007076)4.79275053
7regulation of translational fidelity (GO:0006450)4.77205063
8nuclear pore organization (GO:0006999)4.74347360
9mitotic sister chromatid segregation (GO:0000070)4.66044596
10mitotic sister chromatid cohesion (GO:0007064)4.65427231
11protein localization to chromosome, centromeric region (GO:0071459)4.51623415
12mitotic metaphase plate congression (GO:0007080)4.47616701
13regulation of histone methylation (GO:0031060)4.45550128
14DNA topological change (GO:0006265)4.44442475
15regulation of nucleobase-containing compound transport (GO:0032239)4.44401801
16sister chromatid segregation (GO:0000819)4.33215717
17definitive hemopoiesis (GO:0060216)4.29067209
18* mitotic nuclear envelope disassembly (GO:0007077)4.16711632
19kinetochore organization (GO:0051383)4.05547214
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.04226154
21metaphase plate congression (GO:0051310)4.00096085
22regulation of spindle organization (GO:0090224)3.99929276
23positive regulation of gamma-delta T cell activation (GO:0046645)3.97653031
24pore complex assembly (GO:0046931)3.95087080
25erythrocyte maturation (GO:0043249)3.94524475
26gas transport (GO:0015669)3.93832027
27regulation of sister chromatid cohesion (GO:0007063)3.93755846
28granulocyte differentiation (GO:0030851)3.92475721
29synapsis (GO:0007129)3.91095992
30oxygen transport (GO:0015671)3.88556594
31positive regulation of chromosome segregation (GO:0051984)3.88372175
32DNA replication checkpoint (GO:0000076)3.84950752
33* membrane disassembly (GO:0030397)3.84549013
34* nuclear envelope disassembly (GO:0051081)3.84549013
35DNA synthesis involved in DNA repair (GO:0000731)3.83019637
36establishment of chromosome localization (GO:0051303)3.82601105
37positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.82177101
38positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.82177101
39positive regulation of mitotic sister chromatid separation (GO:1901970)3.82177101
40meiotic chromosome segregation (GO:0045132)3.79018049
41regulation of mitotic spindle organization (GO:0060236)3.75659238
42kinetochore assembly (GO:0051382)3.71363390
43attachment of spindle microtubules to kinetochore (GO:0008608)3.71344124
44negative regulation of histone methylation (GO:0031061)3.69790087
45protein localization to chromosome (GO:0034502)3.66260726
46histone H3-K4 trimethylation (GO:0080182)3.64335391
47diterpenoid biosynthetic process (GO:0016102)3.60975170
48pre-miRNA processing (GO:0031054)3.56790048
49erythrocyte development (GO:0048821)3.56382059
50DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.53170083
51protoporphyrinogen IX metabolic process (GO:0046501)3.51278570
52histone H2A monoubiquitination (GO:0035518)3.48737715
53regulation of gamma-delta T cell differentiation (GO:0045586)3.48148128
54negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.45367815
55chromosome segregation (GO:0007059)3.38185924
56vitamin A metabolic process (GO:0006776)3.36562616
57histone lysine methylation (GO:0034968)3.35597235
58histone H3-K9 demethylation (GO:0033169)3.35320558
59N-terminal protein amino acid acetylation (GO:0006474)3.33566624
60DNA unwinding involved in DNA replication (GO:0006268)3.33435536
61DNA methylation involved in gamete generation (GO:0043046)3.33326276
62nucleosome disassembly (GO:0006337)3.32167924
63protein-DNA complex disassembly (GO:0032986)3.32167924
64DNA replication initiation (GO:0006270)3.32100921
65regulation of chromosome segregation (GO:0051983)3.30132771
66DNA damage response, signal transduction resulting in transcription (GO:0042772)3.29129771
67positive regulation of histone methylation (GO:0031062)3.29099081
68microtubule depolymerization (GO:0007019)3.27906939
69histone methylation (GO:0016571)3.27070444
70Peyers patch development (GO:0048541)3.25611992
71mucosal-associated lymphoid tissue development (GO:0048537)3.25611992
72DNA replication-dependent nucleosome organization (GO:0034723)3.21661608
73DNA replication-dependent nucleosome assembly (GO:0006335)3.21661608
74poly(A)+ mRNA export from nucleus (GO:0016973)3.18932678
75DNA replication-independent nucleosome assembly (GO:0006336)3.18428024
76DNA replication-independent nucleosome organization (GO:0034724)3.18428024
77resolution of meiotic recombination intermediates (GO:0000712)3.17418945
78gene silencing by RNA (GO:0031047)3.16446796
79positive regulation of granulocyte differentiation (GO:0030854)3.15934819
80regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15825430
81piRNA metabolic process (GO:0034587)3.12454060
82monoubiquitinated protein deubiquitination (GO:0035520)3.11749126
83spindle checkpoint (GO:0031577)3.10960133
84centriole replication (GO:0007099)3.10032698
85regulation of exit from mitosis (GO:0007096)3.09462188
86positive regulation of B cell differentiation (GO:0045579)3.08584887
87sister chromatid cohesion (GO:0007062)3.07353062
88regulation of histone H3-K9 methylation (GO:0051570)3.07140904
89regulation of gamma-delta T cell activation (GO:0046643)3.06836307
90chromatin assembly or disassembly (GO:0006333)3.06702280
91maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.05497005
92* nuclear envelope organization (GO:0006998)3.05424452
93regulation of mitotic metaphase/anaphase transition (GO:0030071)3.05136308
94DNA strand elongation involved in DNA replication (GO:0006271)3.04467023
95DNA methylation (GO:0006306)3.04441920
96DNA alkylation (GO:0006305)3.04441920
97chromatin remodeling at centromere (GO:0031055)3.01010481
98centriole assembly (GO:0098534)3.00842099
99CENP-A containing nucleosome assembly (GO:0034080)3.00554499
100positive regulation of histone H3-K4 methylation (GO:0051571)3.00553121
101regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00206875
102regulation of RNA export from nucleus (GO:0046831)2.99442456
103negative regulation of histone modification (GO:0031057)2.99414780
104protein K6-linked ubiquitination (GO:0085020)2.98458375
105dosage compensation (GO:0007549)2.97822088
106regulation of centrosome cycle (GO:0046605)2.97392195
107regulation of erythrocyte differentiation (GO:0045646)2.97307405
108regulation of telomere maintenance via telomerase (GO:0032210)2.97032161
109chromosome condensation (GO:0030261)2.96572697
110regulation of centriole replication (GO:0046599)2.96164177
111heterochromatin organization (GO:0070828)2.96006815
112histone H4-K16 acetylation (GO:0043984)2.95442340
113chromosome organization involved in meiosis (GO:0070192)2.94043804
114negative regulation of chromosome segregation (GO:0051985)2.93348056
115regulation of gene expression by genetic imprinting (GO:0006349)2.92535710
116DNA duplex unwinding (GO:0032508)2.91590773
117DNA geometric change (GO:0032392)2.91361304
118regulation of mitotic sister chromatid separation (GO:0010965)2.90997715
119regulation of mitotic sister chromatid segregation (GO:0033047)2.90997715
120regulation of sister chromatid segregation (GO:0033045)2.90997715
121DNA strand elongation (GO:0022616)2.90602029
122spindle assembly checkpoint (GO:0071173)2.89580708
123response to vitamin A (GO:0033189)2.89093511
124positive regulation of protein import into nucleus, translocation (GO:0033160)2.88677294
125histone lysine demethylation (GO:0070076)2.88618424
126histone demethylation (GO:0016577)2.86753027
127histone H3-K36 demethylation (GO:0070544)2.84535763
128negative regulation of mitotic sister chromatid separation (GO:2000816)2.84403021
129negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84403021
130negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84403021
131negative regulation of sister chromatid segregation (GO:0033046)2.84403021
132mitotic spindle checkpoint (GO:0071174)2.83878479
133telomere maintenance via recombination (GO:0000722)2.83464966
134peptidyl-lysine trimethylation (GO:0018023)2.83293706
135mitotic spindle assembly checkpoint (GO:0007094)2.82640378
136positive regulation of DNA-dependent DNA replication (GO:2000105)2.82612591
137intra-S DNA damage checkpoint (GO:0031573)2.82206852
138DNA packaging (GO:0006323)2.81871294
139mannose metabolic process (GO:0006013)2.79319854
140protoporphyrinogen IX biosynthetic process (GO:0006782)2.79144029
141mitotic recombination (GO:0006312)2.78680103
142negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.78633557
143regulation of retinoic acid receptor signaling pathway (GO:0048385)2.78527713
144histone H3-K4 methylation (GO:0051568)2.78382534
145ATP-dependent chromatin remodeling (GO:0043044)2.77469886
146cytoplasmic mRNA processing body assembly (GO:0033962)2.77350038
147histone exchange (GO:0043486)2.77331954
148meiotic cell cycle (GO:0051321)2.77235599
149histone H3-K9 modification (GO:0061647)2.76974715
150glucocorticoid receptor signaling pathway (GO:0042921)2.76084171
151nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.75953961
152DNA conformation change (GO:0071103)2.75102730
153negative regulation of chromatin modification (GO:1903309)2.74777530
154histone H3-K9 methylation (GO:0051567)2.73665986
155telomere maintenance via semi-conservative replication (GO:0032201)2.70779289
156mRNA stabilization (GO:0048255)2.70188411
157RNA stabilization (GO:0043489)2.70188411
158JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.70072686
159positive regulation of gene expression, epigenetic (GO:0045815)2.68916272
160histone deubiquitination (GO:0016578)2.68030032
161* mRNA transport (GO:0051028)2.67711379

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.70014479
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.44603564
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.09812920
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.85016114
5* NCOR1_26117541_ChIP-Seq_K562_Human2.81628412
6MYC_22102868_ChIP-Seq_BL_Human2.80440995
7E2F1_21310950_ChIP-Seq_MCF-7_Human2.66780754
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.66667513
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.60314205
10GATA1_19941826_ChIP-Seq_K562_Human2.58552980
11GATA1_22025678_ChIP-Seq_K562_Human2.55655838
12AR_21909140_ChIP-Seq_LNCAP_Human2.52209050
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24742955
14* SPI1_23127762_ChIP-Seq_K562_Human2.23204825
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.19800384
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06348488
17E2F7_22180533_ChIP-Seq_HELA_Human10.5872800
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.96123575
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89368499
20GATA2_19941826_ChIP-Seq_K562_Human1.86800003
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84214060
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83993122
23CIITA_25753668_ChIP-Seq_RAJI_Human1.81012585
24* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77540291
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75410858
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72469849
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71621204
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70982300
29* EST1_17652178_ChIP-ChIP_JURKAT_Human1.58054442
30* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52417971
31MAF_26560356_Chip-Seq_TH2_Human1.52041214
32KDM5A_27292631_Chip-Seq_BREAST_Human1.50151747
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48956848
34* XRN2_22483619_ChIP-Seq_HELA_Human1.47393249
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44786456
36VDR_21846776_ChIP-Seq_THP-1_Human1.44530178
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41931547
38* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40690330
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36252513
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35110331
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34795461
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29286810
43VDR_23849224_ChIP-Seq_CD4+_Human1.28649471
44TCF7_22412390_ChIP-Seq_EML_Mouse1.28355688
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28293980
46E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.27876632
47FOXP3_21729870_ChIP-Seq_TREG_Human1.27872921
48* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25721745
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21675198
50GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20979636
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.20286534
52UTX_26944678_Chip-Seq_JUKART_Human1.20189368
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19376662
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19134667
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18802785
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17350637
57* GABP_19822575_ChIP-Seq_HepG2_Human1.16608603
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16051320
59* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15151310
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15036218
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13697128
62* TTF2_22483619_ChIP-Seq_HELA_Human1.13629566
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13438269
64NANOG_21062744_ChIP-ChIP_HESCs_Human1.13355192
65MYB_26560356_Chip-Seq_TH1_Human1.13292565
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12767633
67P68_20966046_ChIP-Seq_HELA_Human1.12704799
68* ETS1_20019798_ChIP-Seq_JURKAT_Human1.12537538
69VDR_24763502_ChIP-Seq_THP-1_Human1.10527541
70MYB_26560356_Chip-Seq_TH2_Human1.10395808
71* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10064120
72SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09117306
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08710914
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08252685
75* LXR_22292898_ChIP-Seq_THP-1_Human1.05457782
76TFEB_21752829_ChIP-Seq_HELA_Human1.04742791
77* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04621661
78* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04237192
79PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03903576
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.03598999
81* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03174248
82* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01738797
83* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00970895
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00250452
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00183773
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99962673
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99844947
88KDM2B_26808549_Chip-Seq_JURKAT_Human0.99438030
89FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99223469
90GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99053698
91GATA1_19941827_ChIP-Seq_MEL_Mouse0.98100831
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98083974
93MAF_26560356_Chip-Seq_TH1_Human0.98066385
94MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96600719
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96283757
96* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95072129
97CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94743691
98NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94180409
99DCP1A_22483619_ChIP-Seq_HELA_Human0.94152837
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92956082
101* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92914186
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92845535
103E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92584917
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92462284
105TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92236602
106CREB1_26743006_Chip-Seq_LNCaP_Human0.92227894
107MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92009788
108* SPI1_23547873_ChIP-Seq_NB4_Human0.91840047
109EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91106250
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90632751
111E2F1_20622854_ChIP-Seq_HELA_Human0.90617459
112ELK1_19687146_ChIP-ChIP_HELA_Human0.89757340
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89680537
114STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89296220
115BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88855767
116BCOR_27268052_Chip-Seq_Bcells_Human0.88460458
117HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.87979209
118THAP11_20581084_ChIP-Seq_MESCs_Mouse0.87292647
119FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.86616532
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86389038
121NOTCH1_21737748_ChIP-Seq_TLL_Human0.86368361
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85804512
123FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84562662
124PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83588184
125IRF8_21731497_ChIP-ChIP_J774_Mouse0.83552878
126NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.82738281
127STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82103903
128* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.81609000
129KDM2B_26808549_Chip-Seq_DND41_Human0.80653480
130SCL_19346495_ChIP-Seq_HPC-7_Human0.78384554
131RUNX1_22412390_ChIP-Seq_EML_Mouse0.77388236
132IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.76738787
133SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76610675
134TCF3_18692474_ChIP-Seq_MESCs_Mouse0.75785126
135CHD1_26751641_Chip-Seq_LNCaP_Human0.74425242
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.73566292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.04322811
2MP0003693_abnormal_embryo_hatching3.97869602
3MP0003111_abnormal_nucleus_morphology3.80841276
4MP0008057_abnormal_DNA_replication3.64834242
5MP0003077_abnormal_cell_cycle3.52665909
6MP0000678_abnormal_parathyroid_gland3.51803714
7* MP0004957_abnormal_blastocyst_morpholog3.01936121
8MP0008877_abnormal_DNA_methylation2.98935266
9MP0002132_abnormal_respiratory_system2.66533255
10MP0002396_abnormal_hematopoietic_system2.51193046
11MP0008007_abnormal_cellular_replicative2.42658572
12MP0004147_increased_porphyrin_level2.38578876
13MP0003121_genomic_imprinting2.31345680
14MP0008058_abnormal_DNA_repair2.28971840
15MP0003787_abnormal_imprinting2.22918529
16MP0005083_abnormal_biliary_tract2.21911401
17MP0003656_abnormal_erythrocyte_physiolo2.20025217
18MP0001730_embryonic_growth_arrest2.15472981
19MP0000350_abnormal_cell_proliferation2.13703896
20MP0010352_gastrointestinal_tract_polyps2.01244455
21MP0003123_paternal_imprinting2.00003089
22MP0010307_abnormal_tumor_latency1.96423179
23MP0003718_maternal_effect1.94995195
24MP0001873_stomach_inflammation1.86005222
25MP0001672_abnormal_embryogenesis/_devel1.85416017
26MP0005380_embryogenesis_phenotype1.85416017
27MP0008932_abnormal_embryonic_tissue1.84878741
28MP0005076_abnormal_cell_differentiation1.80552019
29MP0004808_abnormal_hematopoietic_stem1.80542578
30MP0001697_abnormal_embryo_size1.75188271
31MP0002085_abnormal_embryonic_tissue1.69851555
32MP0002653_abnormal_ependyma_morphology1.69340655
33MP0003984_embryonic_growth_retardation1.69104755
34MP0002088_abnormal_embryonic_growth/wei1.64151676
35MP0002084_abnormal_developmental_patter1.62481491
36MP0003763_abnormal_thymus_physiology1.55508287
37MP0002009_preneoplasia1.52600629
38MP0005410_abnormal_fertilization1.52109424
39MP0002086_abnormal_extraembryonic_tissu1.51680688
40MP0000569_abnormal_digit_pigmentation1.47820059
41MP0004233_abnormal_muscle_weight1.45756067
42MP0001348_abnormal_lacrimal_gland1.45687414
43MP0001545_abnormal_hematopoietic_system1.38831474
44MP0005397_hematopoietic_system_phenotyp1.38831474
45* MP0002080_prenatal_lethality1.34801821
46MP0003698_abnormal_male_reproductive1.32633280
47MP0009278_abnormal_bone_marrow1.32358429
48MP0000490_abnormal_crypts_of1.31213189
49MP0001915_intracranial_hemorrhage1.30974063
50MP0003786_premature_aging1.29205893
51MP0002210_abnormal_sex_determination1.28837687
52MP0002019_abnormal_tumor_incidence1.28247528
53MP0001929_abnormal_gametogenesis1.28192046
54MP0003705_abnormal_hypodermis_morpholog1.26582235
55MP0000313_abnormal_cell_death1.26390635
56MP0000703_abnormal_thymus_morphology1.25784337
57MP0002398_abnormal_bone_marrow1.24318808
58MP0009115_abnormal_fat_cell1.23472908
59MP0004197_abnormal_fetal_growth/weight/1.21943379
60MP0004264_abnormal_extraembryonic_tissu1.20270048
61MP0009697_abnormal_copulation1.16181069
62MP0001119_abnormal_female_reproductive1.16020483
63MP0002102_abnormal_ear_morphology1.14886286
64MP0003890_abnormal_embryonic-extraembry1.13516767
65MP0008961_abnormal_basal_metabolism1.09443027
66MP0000653_abnormal_sex_gland1.06996075
67MP0010030_abnormal_orbit_morphology1.06886643
68MP0006292_abnormal_olfactory_placode1.06886049
69MP0000733_abnormal_muscle_development1.03951424
70MP0001661_extended_life_span1.03209723
71MP0009333_abnormal_splenocyte_physiolog1.03130268
72MP0001145_abnormal_male_reproductive1.02838281
73MP0003959_abnormal_lean_body1.01896456
74MP0003436_decreased_susceptibility_to1.00571763
75MP0002722_abnormal_immune_system1.00224388
76MP0003699_abnormal_female_reproductive1.00061642
77MP0000689_abnormal_spleen_morphology0.98666444
78MP0002970_abnormal_white_adipose0.98283571
79MP0002925_abnormal_cardiovascular_devel0.96343319
80MP0002877_abnormal_melanocyte_morpholog0.95635351
81MP0004381_abnormal_hair_follicle0.94184240
82MP0003937_abnormal_limbs/digits/tail_de0.93775824
83MP0005621_abnormal_cell_physiology0.93172539
84MP0004145_abnormal_muscle_electrophysio0.91655481
85MP0005464_abnormal_platelet_physiology0.91356795
86MP0003566_abnormal_cell_adhesion0.89578735
87MP0003172_abnormal_lysosome_physiology0.89151451
88MP0005023_abnormal_wound_healing0.89142323
89MP0008995_early_reproductive_senescence0.88193724
90MP0001800_abnormal_humoral_immune0.88151467
91MP0004947_skin_inflammation0.88083702
92MP0001849_ear_inflammation0.87637498
93MP0001853_heart_inflammation0.86441539
94MP0005395_other_phenotype0.86166764
95MP0004185_abnormal_adipocyte_glucose0.85560343
96MP0000432_abnormal_head_morphology0.85234246
97MP0003935_abnormal_craniofacial_develop0.85120775
98MP0000015_abnormal_ear_pigmentation0.84840781
99MP0009931_abnormal_skin_appearance0.83548388
100MP0002429_abnormal_blood_cell0.83388615
101MP0000716_abnormal_immune_system0.83151862
102MP0000681_abnormal_thyroid_gland0.82215340
103MP0005384_cellular_phenotype0.81247463
104MP0002405_respiratory_system_inflammati0.80544717
105MP0009672_abnormal_birth_weight0.80478545
106MP0001835_abnormal_antigen_presentation0.79599788
107MP0000609_abnormal_liver_physiology0.79557201
108MP0010368_abnormal_lymphatic_system0.78408680
109MP0000428_abnormal_craniofacial_morphol0.78338064
110MP0003943_abnormal_hepatobiliary_system0.78303063
111MP0009703_decreased_birth_body0.78290282
112MP0005451_abnormal_body_composition0.77721438
113MP0001293_anophthalmia0.77608931
114MP0006035_abnormal_mitochondrial_morpho0.76671189
115MP0003567_abnormal_fetal_cardiomyocyte0.76356996
116MP0005408_hypopigmentation0.75905847
117MP0002723_abnormal_immune_serum0.74933064
118MP0003300_gastrointestinal_ulcer0.73964962
119MP0003303_peritoneal_inflammation0.71530806
120MP0003115_abnormal_respiratory_system0.71063915
121MP0002419_abnormal_innate_immunity0.70840790
122MP0010630_abnormal_cardiac_muscle0.69645872
123MP0003941_abnormal_skin_development0.69495727
124MP0002006_tumorigenesis0.69412454
125MP0002452_abnormal_antigen_presenting0.68387717
126MP0000266_abnormal_heart_morphology0.68038436
127MP0002420_abnormal_adaptive_immunity0.67720371
128MP0000598_abnormal_liver_morphology0.67245476
129MP0001819_abnormal_immune_cell0.66806387
130MP0005409_darkened_coat_color0.66439258
131MP0005666_abnormal_adipose_tissue0.65967173
132MP0005025_abnormal_response_to0.65422322
133MP0002161_abnormal_fertility/fecundity0.65405448
134MP0003755_abnormal_palate_morphology0.64348437
135MP0005310_abnormal_salivary_gland0.64324799
136MP0003091_abnormal_cell_migration0.63247111
137MP0000767_abnormal_smooth_muscle0.63126857
138MP0003646_muscle_fatigue0.62123912
139MP0008770_decreased_survivor_rate0.61839607
140MP0002249_abnormal_larynx_morphology0.61653081

Predicted human phenotypes

RankGene SetZ-score
1Truncus arteriosus (HP:0001660)5.42765104
2Cholecystitis (HP:0001082)5.15991153
3Abnormal gallbladder physiology (HP:0012438)5.15991153
4Hyperthyroidism (HP:0000836)4.95944824
5Reticulocytosis (HP:0001923)4.70737395
6Chromsome breakage (HP:0040012)4.63313481
7Ankyloglossia (HP:0010296)4.35650408
8Abnormality of the fingertips (HP:0001211)4.23963014
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.22531893
10Polycythemia (HP:0001901)4.07598150
11Abnormality of reticulocytes (HP:0004312)3.91062899
12Bowel incontinence (HP:0002607)3.86368769
13Abnormality of cochlea (HP:0000375)3.85320002
14Abnormal large intestine physiology (HP:0012700)3.63612509
15Abnormality of homocysteine metabolism (HP:0010919)3.58787825
16Homocystinuria (HP:0002156)3.58787825
17Seborrheic dermatitis (HP:0001051)3.54630121
18Hypertensive crisis (HP:0100735)3.53956551
19Abnormality of the heme biosynthetic pathway (HP:0010472)3.42719029
20Volvulus (HP:0002580)3.37233671
21Long eyelashes (HP:0000527)3.30267635
22Ectopic kidney (HP:0000086)3.29532843
23Abnormality of the renal collecting system (HP:0004742)3.21025494
24Neoplasm of the oral cavity (HP:0100649)3.17201587
25Abnormality of chromosome stability (HP:0003220)3.16015583
26Hypoparathyroidism (HP:0000829)3.11929037
27Abnormality of oral frenula (HP:0000190)3.10774460
28Birth length less than 3rd percentile (HP:0003561)3.07307553
29Patellar aplasia (HP:0006443)3.05966750
30Duplicated collecting system (HP:0000081)3.03983332
31Aplasia/Hypoplasia of the thymus (HP:0010515)3.01966091
32Short middle phalanx of the 5th finger (HP:0004220)2.99992445
33Facial hemangioma (HP:0000329)2.92971538
34Atelectasis (HP:0100750)2.89308440
35Abnormality of the labia minora (HP:0012880)2.86594846
36Poikilocytosis (HP:0004447)2.84257496
37High pitched voice (HP:0001620)2.81143200
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.80745900
39Morphological abnormality of the inner ear (HP:0011390)2.79456201
40Medulloblastoma (HP:0002885)2.78417991
41Prominent nose (HP:0000448)2.77713749
42Aplasia/Hypoplasia of the patella (HP:0006498)2.73893357
43Abnormality of the tricuspid valve (HP:0001702)2.72267418
44Obstructive lung disease (HP:0006536)2.71540028
45Chronic obstructive pulmonary disease (HP:0006510)2.71540028
46Impulsivity (HP:0100710)2.70140601
47Ileus (HP:0002595)2.70135697
48Obsessive-compulsive behavior (HP:0000722)2.69955971
49Meckel diverticulum (HP:0002245)2.69345103
50Abnormality of the preputium (HP:0100587)2.67019403
51Abnormality of the ileum (HP:0001549)2.64990407
52Myelodysplasia (HP:0002863)2.56992969
53Cholelithiasis (HP:0001081)2.56709874
54Papillary thyroid carcinoma (HP:0002895)2.56694217
55Short 4th metacarpal (HP:0010044)2.54488714
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.54488714
57Pallor (HP:0000980)2.53046724
58Skull defect (HP:0001362)2.46954857
59Abnormal hemoglobin (HP:0011902)2.46822568
60Acanthocytosis (HP:0001927)2.45230074
61Dysmetric saccades (HP:0000641)2.40227114
62Shawl scrotum (HP:0000049)2.39449678
63Disproportionate tall stature (HP:0001519)2.35461664
64Small intestinal stenosis (HP:0012848)2.35431607
65Duodenal stenosis (HP:0100867)2.35431607
66Sparse lateral eyebrow (HP:0005338)2.34515894
67Increased nuchal translucency (HP:0010880)2.33361362
68Abnormally folded helix (HP:0008544)2.28546418
69Patellar dislocation (HP:0002999)2.27382531
70Deviation of the thumb (HP:0009603)2.25787307
71Breast hypoplasia (HP:0003187)2.25580797
72Clubbing of toes (HP:0100760)2.24361320
73Abnormality of the thymus (HP:0000777)2.24112394
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23919779
75Trigonocephaly (HP:0000243)2.22916991
76Reticulocytopenia (HP:0001896)2.22861185
77Rhabdomyosarcoma (HP:0002859)2.22541021
78Wrist flexion contracture (HP:0001239)2.22312964
79Abnormality of the carotid arteries (HP:0005344)2.21777223
80Ependymoma (HP:0002888)2.21613234
81Sloping forehead (HP:0000340)2.20682002
82Lip pit (HP:0100267)2.19777547
83Cafe-au-lait spot (HP:0000957)2.19673684
84Macroorchidism (HP:0000053)2.18525512
85Selective tooth agenesis (HP:0001592)2.16883758
86Abnormal gallbladder morphology (HP:0012437)2.16128401
87Proximal placement of thumb (HP:0009623)2.13402147
88Sandal gap (HP:0001852)2.13216732
89Deep philtrum (HP:0002002)2.12458840
90Urethral obstruction (HP:0000796)2.10059432
91* Acute myeloid leukemia (HP:0004808)2.09666118
92Attention deficit hyperactivity disorder (HP:0007018)2.04693587
93Aplasia/Hypoplasia of the sternum (HP:0006714)2.03856872
94Truncal obesity (HP:0001956)2.03388066
95Short thumb (HP:0009778)2.02242747
96Prolonged bleeding time (HP:0003010)2.01929094
97Abnormality of chromosome segregation (HP:0002916)2.01173236
98Abnormality of the gallbladder (HP:0005264)1.99098831
99Neoplasm of striated muscle (HP:0009728)1.97723069
100Abnormal number of incisors (HP:0011064)1.96415004
101Flat cornea (HP:0007720)1.94141349
102Overlapping toe (HP:0001845)1.93638601
103Spondylolisthesis (HP:0003302)1.92874653
104Relative macrocephaly (HP:0004482)1.92120754
105Acute lymphatic leukemia (HP:0006721)1.92024125
106Peripheral hypomyelination (HP:0007182)1.91560094
107Capillary hemangiomas (HP:0005306)1.90524286
108Self-mutilation (HP:0000742)1.89862263
109Abnormality of pyrimidine metabolism (HP:0004353)1.88884679
110Abnormality of the duodenum (HP:0002246)1.88554996
111Absent radius (HP:0003974)1.87493030
112Heterotopia (HP:0002282)1.86989299
113Agnosia (HP:0010524)1.86424694
114Oligodactyly (HP:0012165)1.86196427
115Short 5th finger (HP:0009237)1.84991884
116Granulocytopenia (HP:0001913)1.84890113
117Nonimmune hydrops fetalis (HP:0001790)1.84455944
118Bone marrow hypocellularity (HP:0005528)1.82427746
119Septate vagina (HP:0001153)1.82143319
120Broad palm (HP:0001169)1.81365690
121Tinnitus (HP:0000360)1.81280828
122Intestinal malrotation (HP:0002566)1.79784452
123Cheekbone underdevelopment (HP:0010669)1.79283110
124Abnormal lung lobation (HP:0002101)1.79134398
125Abnormality of the columella (HP:0009929)1.78905437
126Fatigue (HP:0012378)1.78868768
127Depressed nasal tip (HP:0000437)1.76990467
128Midline defect of the nose (HP:0004122)1.76977720
129Hypoplastic iliac wings (HP:0002866)1.76530940
130Protrusio acetabuli (HP:0003179)1.76464071
131Degeneration of anterior horn cells (HP:0002398)1.75856674
132Abnormality of the anterior horn cell (HP:0006802)1.75856674
133Anal stenosis (HP:0002025)1.75116009
134Microtia (HP:0008551)1.75102469
135Nephroblastoma (Wilms tumor) (HP:0002667)1.74160966
136Male infertility (HP:0003251)1.73979615
137Hypoplastic labia majora (HP:0000059)1.73176187
138Rib fusion (HP:0000902)1.72678087
139Absent forearm bone (HP:0003953)1.72516905
140Aplasia involving forearm bones (HP:0009822)1.72516905
141Upper limb muscle weakness (HP:0003484)1.72491122
142Colitis (HP:0002583)1.71758746
143Astrocytoma (HP:0009592)1.71530606
144Abnormality of the astrocytes (HP:0100707)1.71530606
145Low anterior hairline (HP:0000294)1.69870461
146Overfolded helix (HP:0000396)1.69822279
147Supernumerary spleens (HP:0009799)1.69669434
148Atresia of the external auditory canal (HP:0000413)1.69160114
149Deep palmar crease (HP:0006191)1.66941646
150Abnormality of the parathyroid morphology (HP:0011766)1.66508720
151Broad thumb (HP:0011304)1.66309428
152Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.65873641
153Premature ovarian failure (HP:0008209)1.65604376
154Abnormality of the aortic arch (HP:0012303)1.65553209
155Limited elbow extension (HP:0001377)1.65252884
156Pulmonary fibrosis (HP:0002206)1.65011642
157Sparse scalp hair (HP:0002209)1.64987018
158Abnormality of DNA repair (HP:0003254)1.64866110
159Basal cell carcinoma (HP:0002671)1.64759628
160Tracheoesophageal fistula (HP:0002575)1.64676280
161Increased IgE level (HP:0003212)1.64542274
162Polycystic kidney dysplasia (HP:0000113)1.64192521
163Cortical dysplasia (HP:0002539)1.63980775
164Hypergonadotropic hypogonadism (HP:0000815)1.63669674
165Flat capital femoral epiphysis (HP:0003370)1.61812050
166Ureteral duplication (HP:0000073)1.61172913
167Cutis marmorata (HP:0000965)1.61018399
168Absent thumb (HP:0009777)1.60132878
169Blepharitis (HP:0000498)1.60077659
170Gastrointestinal carcinoma (HP:0002672)1.59427917
171Malignant gastrointestinal tract tumors (HP:0006749)1.59427917
172Aplasia/Hypoplasia of the earlobes (HP:0009906)1.58407600
173Cerebral aneurysm (HP:0004944)1.56275872

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.96678969
2CDC74.41328931
3RIPK44.41076657
4EEF2K3.60591112
5NEK23.22570802
6LATS13.06028325
7TTK2.73488053
8PLK42.52517370
9MAP3K22.41637955
10STK102.19742606
11ERN12.01296090
12CHEK21.97833107
13BRD41.97670132
14SMG11.96240557
15SCYL21.93082708
16MAP4K11.85808715
17STK31.84879649
18WEE11.78585019
19LATS21.76324974
20PLK11.73924327
21BRSK21.72665811
22MAP3K61.72170521
23BUB11.67093177
24CDK71.63945533
25PASK1.62377194
26ATR1.56917887
27CHEK11.55882596
28RPS6KB21.54243624
29CDK41.52533561
30PRPF4B1.51471599
31TAOK11.49941104
32MELK1.48120090
33TAOK31.44831009
34NTRK31.44595941
35AURKB1.41320587
36BMPR21.40954467
37KSR11.40116643
38STK38L1.37400308
39PDK21.36491916
40CDK91.31632459
41WNK11.25791827
42ATM1.19942387
43MAP3K101.18826939
44MAP3K81.18014482
45PRKD31.14445592
46BRSK11.09964565
47MTOR1.08304331
48STK41.07937956
49CCNB11.04534845
50CDK81.04518796
51SRPK11.02918333
52EIF2AK11.02186282
53RPS6KA41.01982079
54TNK21.01457383
55NME10.98930245
56PLK30.96869572
57CDK20.96343868
58JAK20.94281114
59CDK60.92794020
60MAP3K70.92227638
61MAP2K30.91799478
62PKN20.89915514
63TRIB30.87710651
64MAP3K10.85527560
65TSSK60.84489691
66PIM10.83806044
67FGFR30.83568804
68JAK30.82982647
69DMPK0.81727443
70ACVR1B0.81644005
71TYRO30.81336250
72IRAK40.81062044
73RET0.81024110
74TEC0.79714971
75BRAF0.79140505
76FGFR40.78987375
77CHUK0.75975849
78MKNK20.74837459
79NUAK10.74154520
80IRAK30.73827168
81ERBB40.73367872
82TYK20.71606283
83* CDK10.71347827
84BLK0.71059831
85HCK0.70471659
86CAMK1D0.70121371
87PRKD20.69465209
88PAK40.68724465
89MAPKAPK30.67664556
90RAF10.67292663
91NEK10.67248347
92TRPM70.65540387
93ALK0.65007582
94TESK20.64665836
95MKNK10.64316818
96EPHB10.63975055
97SIK20.63407923
98AURKA0.62058547
99ICK0.61939266
100WNK40.61007393
101SGK10.58707479
102VRK10.58417044
103BMX0.58363795
104YES10.56020125
105PTK60.55454655
106SYK0.54053731
107MAPK140.52992198
108CDK30.51121386
109HIPK20.50937931
110MAP2K10.47894375
111PDK10.47801333
112TGFBR10.47012410
113PDPK10.46695416
114STK240.44954239
115CSF1R0.44486482
116AKT10.43596112
117KIT0.43243576
118CDC42BPA0.42820814
119RIPK10.42273731
120CSNK1D0.41939639
121MAPKAPK50.40587699
122SIK10.40559088
123MAP3K130.40073953
124* MAPK100.39457722
125ZAP700.39024236
126CAMK1G0.38830290
127PIK3CG0.38518666
128PAK10.36496724
129LRRK20.35790489
130* GSK3B0.34822496
131* MAPK10.34324791
132MAPK110.32891092
133NLK0.32228739
134PRKDC0.32198987
135KSR20.31214266
136MARK20.30522524
137BTK0.30207488
138DYRK30.29565023
139TXK0.29483292
140PRKAA10.29385662
141PRKAA20.29132928
142CSNK1E0.29114450
143FLT30.28163825
144MARK30.28119113
145CLK10.27977400

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.69465788
2DNA replication_Homo sapiens_hsa030303.33197644
3Cell cycle_Homo sapiens_hsa041103.24374680
4Mismatch repair_Homo sapiens_hsa034302.91869415
5Homologous recombination_Homo sapiens_hsa034402.72501975
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59319849
7* RNA transport_Homo sapiens_hsa030132.57024616
8Base excision repair_Homo sapiens_hsa034102.44302780
9Fanconi anemia pathway_Homo sapiens_hsa034602.40721602
10RNA degradation_Homo sapiens_hsa030182.32827023
11Non-homologous end-joining_Homo sapiens_hsa034502.23996757
12Spliceosome_Homo sapiens_hsa030402.20404918
13mRNA surveillance pathway_Homo sapiens_hsa030151.94782554
14p53 signaling pathway_Homo sapiens_hsa041151.92420631
15Basal transcription factors_Homo sapiens_hsa030221.90277642
16Nucleotide excision repair_Homo sapiens_hsa034201.86486841
17One carbon pool by folate_Homo sapiens_hsa006701.79037213
18RNA polymerase_Homo sapiens_hsa030201.67389873
19MicroRNAs in cancer_Homo sapiens_hsa052061.53417845
20Type II diabetes mellitus_Homo sapiens_hsa049301.52992771
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40256362
22Herpes simplex infection_Homo sapiens_hsa051681.39046980
23Small cell lung cancer_Homo sapiens_hsa052221.34898223
24Pancreatic cancer_Homo sapiens_hsa052121.30844077
25Olfactory transduction_Homo sapiens_hsa047401.30838824
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28190629
27ErbB signaling pathway_Homo sapiens_hsa040121.27896652
28Notch signaling pathway_Homo sapiens_hsa043301.25784682
29Chronic myeloid leukemia_Homo sapiens_hsa052201.24445026
30HTLV-I infection_Homo sapiens_hsa051661.21889946
31Pyrimidine metabolism_Homo sapiens_hsa002401.19465355
32Colorectal cancer_Homo sapiens_hsa052101.17847939
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14607147
34Adherens junction_Homo sapiens_hsa045201.14546046
35Oocyte meiosis_Homo sapiens_hsa041141.13498632
36Primary immunodeficiency_Homo sapiens_hsa053401.12102448
37Lysine degradation_Homo sapiens_hsa003101.11310216
38TGF-beta signaling pathway_Homo sapiens_hsa043501.10302044
39Antigen processing and presentation_Homo sapiens_hsa046121.09822565
40Viral carcinogenesis_Homo sapiens_hsa052031.09053408
41Inositol phosphate metabolism_Homo sapiens_hsa005621.08542199
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04857615
43Other glycan degradation_Homo sapiens_hsa005111.04591756
44Hepatitis B_Homo sapiens_hsa051611.04386859
45* Epstein-Barr virus infection_Homo sapiens_hsa051691.04102088
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03144804
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.01767994
48Glioma_Homo sapiens_hsa052141.00794969
49mTOR signaling pathway_Homo sapiens_hsa041501.00410214
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94915797
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93013736
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91638378
53Dorso-ventral axis formation_Homo sapiens_hsa043200.91444544
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90434426
55Non-small cell lung cancer_Homo sapiens_hsa052230.89816302
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89063075
57B cell receptor signaling pathway_Homo sapiens_hsa046620.88064760
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87919103
59Viral myocarditis_Homo sapiens_hsa054160.86148970
60Measles_Homo sapiens_hsa051620.86025594
61Acute myeloid leukemia_Homo sapiens_hsa052210.84486333
62Thyroid cancer_Homo sapiens_hsa052160.82338791
63Insulin signaling pathway_Homo sapiens_hsa049100.81677763
64Prostate cancer_Homo sapiens_hsa052150.79284892
65Hippo signaling pathway_Homo sapiens_hsa043900.78604865
66Endometrial cancer_Homo sapiens_hsa052130.78500917
67Apoptosis_Homo sapiens_hsa042100.78094401
68Basal cell carcinoma_Homo sapiens_hsa052170.75408419
69Toxoplasmosis_Homo sapiens_hsa051450.72805849
70Fructose and mannose metabolism_Homo sapiens_hsa000510.71260062
71Hematopoietic cell lineage_Homo sapiens_hsa046400.71126829
72T cell receptor signaling pathway_Homo sapiens_hsa046600.71069359
73Pathways in cancer_Homo sapiens_hsa052000.70437938
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.69906649
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69185511
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68916433
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67633349
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67412935
79FoxO signaling pathway_Homo sapiens_hsa040680.67288080
80Influenza A_Homo sapiens_hsa051640.67086850
81Shigellosis_Homo sapiens_hsa051310.66669815
82Renal cell carcinoma_Homo sapiens_hsa052110.66598545
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65429732
84Leishmaniasis_Homo sapiens_hsa051400.63454506
85Biosynthesis of amino acids_Homo sapiens_hsa012300.62788555
86Prolactin signaling pathway_Homo sapiens_hsa049170.62407831
87Insulin resistance_Homo sapiens_hsa049310.60186610
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59954757
89Purine metabolism_Homo sapiens_hsa002300.59581112
90VEGF signaling pathway_Homo sapiens_hsa043700.59271773
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59088589
92Fatty acid biosynthesis_Homo sapiens_hsa000610.58598233
93Proteoglycans in cancer_Homo sapiens_hsa052050.57164146
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56998698
95Hepatitis C_Homo sapiens_hsa051600.54880620
96TNF signaling pathway_Homo sapiens_hsa046680.54359443
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54000953
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52940500
99Wnt signaling pathway_Homo sapiens_hsa043100.52500167
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.52436926
101Osteoclast differentiation_Homo sapiens_hsa043800.51865232
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.51647197
103HIF-1 signaling pathway_Homo sapiens_hsa040660.51532735
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49908156
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.49094686
106Bladder cancer_Homo sapiens_hsa052190.48683472
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47955491
108Hedgehog signaling pathway_Homo sapiens_hsa043400.47848323
109Ovarian steroidogenesis_Homo sapiens_hsa049130.46963517
110Choline metabolism in cancer_Homo sapiens_hsa052310.46017772
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.45636781
112Estrogen signaling pathway_Homo sapiens_hsa049150.44983221
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44977385
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.44227448
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43566357
116Systemic lupus erythematosus_Homo sapiens_hsa053220.43167660
117Focal adhesion_Homo sapiens_hsa045100.42999917
118Circadian rhythm_Homo sapiens_hsa047100.42840805
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42803321
120Chemokine signaling pathway_Homo sapiens_hsa040620.42780575
121Platelet activation_Homo sapiens_hsa046110.41481186
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.41255468
123Vitamin B6 metabolism_Homo sapiens_hsa007500.40758443
124Carbon metabolism_Homo sapiens_hsa012000.40658062
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39981587
126Legionellosis_Homo sapiens_hsa051340.39080690
127ECM-receptor interaction_Homo sapiens_hsa045120.38830888
128AMPK signaling pathway_Homo sapiens_hsa041520.37725614
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.37474946
130Pentose phosphate pathway_Homo sapiens_hsa000300.34949435
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.34887355

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