NUP35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions, is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.85763715
2attachment of spindle microtubules to kinetochore (GO:0008608)4.93297534
3metaphase plate congression (GO:0051310)4.80553910
4CENP-A containing nucleosome assembly (GO:0034080)4.71632572
5DNA replication checkpoint (GO:0000076)4.66030883
6protein localization to kinetochore (GO:0034501)4.63204897
7chromatin remodeling at centromere (GO:0031055)4.57208462
8regulation of spindle organization (GO:0090224)4.34154154
9protein localization to chromosome, centromeric region (GO:0071459)4.30916095
10DNA double-strand break processing (GO:0000729)4.30780876
11DNA replication-independent nucleosome assembly (GO:0006336)4.29467694
12DNA replication-independent nucleosome organization (GO:0034724)4.29467694
13establishment of chromosome localization (GO:0051303)4.19472121
14maturation of 5.8S rRNA (GO:0000460)4.18748058
15DNA replication initiation (GO:0006270)4.15487680
16ribosome assembly (GO:0042255)4.11990239
17purine nucleobase biosynthetic process (GO:0009113)4.11784740
18histone exchange (GO:0043486)4.04766956
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.99667937
20nucleobase biosynthetic process (GO:0046112)3.97910643
21negative regulation of DNA-dependent DNA replication (GO:2000104)3.90545336
22ribosome biogenesis (GO:0042254)3.89048529
23DNA strand elongation involved in DNA replication (GO:0006271)3.87559461
24regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.87407718
25regulation of mitotic spindle checkpoint (GO:1903504)3.87407718
26proteasome assembly (GO:0043248)3.87295300
27regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.84879074
28spindle checkpoint (GO:0031577)3.82844795
29anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.80957324
30* mitotic nuclear envelope disassembly (GO:0007077)3.80554844
31protein K6-linked ubiquitination (GO:0085020)3.80390948
32positive regulation of chromosome segregation (GO:0051984)3.77742034
33DNA deamination (GO:0045006)3.77013834
34negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.76141664
35DNA replication-dependent nucleosome assembly (GO:0006335)3.75394348
36DNA replication-dependent nucleosome organization (GO:0034723)3.75394348
37kinetochore organization (GO:0051383)3.73533381
38mitotic chromosome condensation (GO:0007076)3.71046271
39rRNA modification (GO:0000154)3.70749483
407-methylguanosine mRNA capping (GO:0006370)3.70007307
41DNA strand elongation (GO:0022616)3.69038547
42kinetochore assembly (GO:0051382)3.66784238
43negative regulation of chromosome segregation (GO:0051985)3.62628241
44RNA capping (GO:0036260)3.62607459
457-methylguanosine RNA capping (GO:0009452)3.62607459
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.62102443
47negative regulation of mitotic sister chromatid segregation (GO:0033048)3.61893057
48negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.61893057
49negative regulation of sister chromatid segregation (GO:0033046)3.61893057
50negative regulation of mitotic sister chromatid separation (GO:2000816)3.61893057
51mitotic sister chromatid segregation (GO:0000070)3.61404826
52telomere maintenance via semi-conservative replication (GO:0032201)3.60221053
53mitotic spindle checkpoint (GO:0071174)3.59572791
54regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.57868757
55regulation of chromosome segregation (GO:0051983)3.56592266
56* nuclear envelope disassembly (GO:0051081)3.53388346
57* membrane disassembly (GO:0030397)3.53388346
58protein deneddylation (GO:0000338)3.53058015
59mitotic spindle assembly checkpoint (GO:0007094)3.52726084
60establishment of integrated proviral latency (GO:0075713)3.52355738
61spindle assembly checkpoint (GO:0071173)3.49700176
62regulation of mitotic spindle organization (GO:0060236)3.49287246
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48896033
64formation of translation preinitiation complex (GO:0001731)3.48490601
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.48230464
66transcription elongation from RNA polymerase I promoter (GO:0006362)3.47722218
67synapsis (GO:0007129)3.46953394
68termination of RNA polymerase I transcription (GO:0006363)3.46746157
69regulation of mitotic metaphase/anaphase transition (GO:0030071)3.46508828
70folic acid metabolic process (GO:0046655)3.42741222
71L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.41224722
72resolution of meiotic recombination intermediates (GO:0000712)3.38727932
73termination of RNA polymerase III transcription (GO:0006386)3.36595161
74transcription elongation from RNA polymerase III promoter (GO:0006385)3.36595161
75telomere maintenance via recombination (GO:0000722)3.36166228
76DNA ligation (GO:0006266)3.36011984
77transcription from RNA polymerase I promoter (GO:0006360)3.35348758
78DNA catabolic process, exonucleolytic (GO:0000738)3.34273768
79regulation of sister chromatid segregation (GO:0033045)3.33182934
80regulation of mitotic sister chromatid separation (GO:0010965)3.33182934
81regulation of mitotic sister chromatid segregation (GO:0033047)3.33182934
82meiotic chromosome segregation (GO:0045132)3.31708118
83regulation of meiosis I (GO:0060631)3.31586319
84IMP biosynthetic process (GO:0006188)3.31269115
85transcription-coupled nucleotide-excision repair (GO:0006283)3.30783127
86protein localization to chromosome (GO:0034502)3.30669666
87maturation of SSU-rRNA (GO:0030490)3.27934832
88ribonucleoprotein complex biogenesis (GO:0022613)3.26876471
89somatic hypermutation of immunoglobulin genes (GO:0016446)3.25921068
90somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25921068
91spliceosomal snRNP assembly (GO:0000387)3.25043696
92establishment of protein localization to mitochondrial membrane (GO:0090151)3.24671521
93rRNA processing (GO:0006364)3.23418424
94regulation of nuclear cell cycle DNA replication (GO:0033262)3.21428711
95transcription elongation from RNA polymerase II promoter (GO:0006368)3.19742328
96centriole replication (GO:0007099)3.19620553
97chromosome segregation (GO:0007059)3.19200480
98cullin deneddylation (GO:0010388)3.17897396
99mitotic recombination (GO:0006312)3.17798287
100positive regulation of mitotic sister chromatid separation (GO:1901970)3.17786861
101positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.17786861
102positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.17786861
103positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.17032064
104transcription initiation from RNA polymerase I promoter (GO:0006361)3.16608899
105negative regulation of ligase activity (GO:0051352)3.16465351
106negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16465351
107regulation of double-strand break repair via homologous recombination (GO:0010569)3.16464000
108regulation of exit from mitosis (GO:0007096)3.15316706
109rRNA metabolic process (GO:0016072)3.13638734
110chromatin assembly or disassembly (GO:0006333)3.13518687
111sister chromatid segregation (GO:0000819)3.13202999
112exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.12443236
113regulation of centriole replication (GO:0046599)3.10405942
114rRNA methylation (GO:0031167)3.09410695
115folic acid-containing compound biosynthetic process (GO:0009396)3.09208156
116negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.08728060
117negative regulation of DNA-templated transcription, elongation (GO:0032785)3.08728060
118regulation of centrosome cycle (GO:0046605)3.07384570
119nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.06668118
120recombinational repair (GO:0000725)3.06262786
121telomere maintenance via telomere lengthening (GO:0010833)3.06103691
122DNA-templated transcription, elongation (GO:0006354)3.05796376
123G1/S transition of mitotic cell cycle (GO:0000082)3.05662159
124replication fork processing (GO:0031297)3.05608683
125postreplication repair (GO:0006301)3.04139511
126double-strand break repair via homologous recombination (GO:0000724)3.02807733
127non-recombinational repair (GO:0000726)3.02332893
128double-strand break repair via nonhomologous end joining (GO:0006303)3.02332893
129nucleotide-excision repair, DNA gap filling (GO:0006297)3.01756909
130RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.01346956
131histone H2A acetylation (GO:0043968)2.95431730
132negative regulation of DNA recombination (GO:0045910)2.94604767
133histone mRNA metabolic process (GO:0008334)2.90405820
134DNA damage response, detection of DNA damage (GO:0042769)2.86393021
135maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84257865
136telomere maintenance via telomerase (GO:0007004)2.83493587
137microtubule depolymerization (GO:0007019)2.82719131
138somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82709337
139somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.82709337
140isotype switching (GO:0045190)2.82709337

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.43667980
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.36469488
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.25916996
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.01183047
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.84893264
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.69206658
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.53079048
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.48201583
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.39279666
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.34633415
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.25635992
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.00089485
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98212498
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.95498685
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91175758
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86623541
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85554685
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60972272
19* AR_21909140_ChIP-Seq_LNCAP_Human2.54126697
20* VDR_23849224_ChIP-Seq_CD4+_Human2.47076135
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46149607
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40933770
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27712911
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.26491217
25DCP1A_22483619_ChIP-Seq_HELA_Human2.23379871
26XRN2_22483619_ChIP-Seq_HELA_Human2.20202639
27* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18549056
28GABP_19822575_ChIP-Seq_HepG2_Human2.15781497
29ZNF274_21170338_ChIP-Seq_K562_Hela2.13610978
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10927813
31EWS_26573619_Chip-Seq_HEK293_Human2.10166922
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06735203
33MYCN_18555785_ChIP-Seq_MESCs_Mouse2.05867329
34FUS_26573619_Chip-Seq_HEK293_Human2.01559870
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00986751
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97834570
37FOXP3_21729870_ChIP-Seq_TREG_Human1.97630669
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97567908
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93930011
40VDR_22108803_ChIP-Seq_LS180_Human1.91063898
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.90431906
42TTF2_22483619_ChIP-Seq_HELA_Human1.89289072
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89184302
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.86590394
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83014220
46* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79001978
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76286127
48* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69714921
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68386246
50* ELK1_19687146_ChIP-ChIP_HELA_Human1.64612530
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61689237
52* YY1_21170310_ChIP-Seq_MESCs_Mouse1.59750330
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.56272323
54* P300_19829295_ChIP-Seq_ESCs_Human1.53701396
55KDM5A_27292631_Chip-Seq_BREAST_Human1.49673827
56IGF1R_20145208_ChIP-Seq_DFB_Human1.49345766
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48281856
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.47127464
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46751473
60TAF15_26573619_Chip-Seq_HEK293_Human1.43205659
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43146468
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42220564
63* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41020728
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38959091
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36651841
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36375882
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33548171
68* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32617373
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.28449973
70CIITA_25753668_ChIP-Seq_RAJI_Human1.27100431
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26928860
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.26847001
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.26149181
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25227614
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25046150
76MYC_18940864_ChIP-ChIP_HL60_Human1.24565957
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22759438
78* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21344419
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20671779
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18359825
81GBX2_23144817_ChIP-Seq_PC3_Human1.18149403
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17900346
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17712916
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17636512
85* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17509999
86IRF1_19129219_ChIP-ChIP_H3396_Human1.16722921
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.12920766
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11387637
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10101288
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09818856
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09493009
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07855945
93SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07133053
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06679245
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.06366353
96KAP1_22055183_ChIP-Seq_ESCs_Mouse1.06197100
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05188094
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04321024
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00100399
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00029470
101* ELK1_22589737_ChIP-Seq_MCF10A_Human0.99431322
102ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99328417
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97676890
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96902499
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96719862
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96331256
107CBP_20019798_ChIP-Seq_JUKART_Human0.96331256
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96282137
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96202890
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96069125
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95887795
112FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95544012
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95204465
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93497133
115TFEB_21752829_ChIP-Seq_HELA_Human0.93319474
116* SOX2_19829295_ChIP-Seq_ESCs_Human0.91207880
117* NANOG_19829295_ChIP-Seq_ESCs_Human0.91207880
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90720556
119NANOG_21062744_ChIP-ChIP_HESCs_Human0.90181848
120* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89648821
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87936070
122TP53_22573176_ChIP-Seq_HFKS_Human0.87657828
123* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87305012
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87254425
125KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86693392
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86693392
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86693392
128ER_23166858_ChIP-Seq_MCF-7_Human0.86559108
129* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85799025
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84272787
131ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83757180
132CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83364867
133DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83163764
134TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76238556
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.75506634
136TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74922231
137NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.74416483
138TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.73630166
139PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72567094
140EGR1_19374776_ChIP-ChIP_THP-1_Human0.70873398
141FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70346611
142KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.70114349
143NANOG_16153702_ChIP-ChIP_HESCs_Human0.69941727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.46520339
2MP0003111_abnormal_nucleus_morphology5.06602369
3MP0004957_abnormal_blastocyst_morpholog4.77166984
4MP0010094_abnormal_chromosome_stability4.74940229
5MP0003077_abnormal_cell_cycle4.29481246
6MP0003718_maternal_effect3.95638816
7MP0008057_abnormal_DNA_replication3.45957691
8MP0008058_abnormal_DNA_repair3.45421696
9MP0008007_abnormal_cellular_replicative2.96141251
10MP0008932_abnormal_embryonic_tissue2.94996430
11MP0008877_abnormal_DNA_methylation2.87230646
12MP0002653_abnormal_ependyma_morphology2.57356477
13MP0009697_abnormal_copulation2.48775847
14MP0003123_paternal_imprinting2.43013268
15MP0001730_embryonic_growth_arrest2.27992131
16MP0000350_abnormal_cell_proliferation2.15069341
17MP0003786_premature_aging2.07313784
18MP0003315_abnormal_perineum_morphology2.06958777
19MP0002210_abnormal_sex_determination1.90311359
20MP0003941_abnormal_skin_development1.84592479
21MP0001929_abnormal_gametogenesis1.81950144
22MP0006292_abnormal_olfactory_placode1.78292185
23MP0005380_embryogenesis_phenotype1.64733337
24MP0001672_abnormal_embryogenesis/_devel1.64733337
25MP0001697_abnormal_embryo_size1.63236933
26MP0000653_abnormal_sex_gland1.60883654
27MP0008260_abnormal_autophagy1.57853495
28MP0001145_abnormal_male_reproductive1.54684535
29MP0002085_abnormal_embryonic_tissue1.54548036
30MP0002080_prenatal_lethality1.47308060
31MP0002102_abnormal_ear_morphology1.47293701
32MP0001119_abnormal_female_reproductive1.46980125
33MP0010307_abnormal_tumor_latency1.44548545
34MP0006072_abnormal_retinal_apoptosis1.40704488
35MP0005395_other_phenotype1.38746425
36MP0000490_abnormal_crypts_of1.36212760
37MP0003806_abnormal_nucleotide_metabolis1.33647156
38MP0003937_abnormal_limbs/digits/tail_de1.32010018
39MP0003984_embryonic_growth_retardation1.30550657
40MP0003195_calcinosis1.30167646
41MP0002084_abnormal_developmental_patter1.29866429
42MP0002396_abnormal_hematopoietic_system1.28494375
43MP0000313_abnormal_cell_death1.27887318
44MP0002088_abnormal_embryonic_growth/wei1.27236225
45MP0000372_irregular_coat_pigmentation1.26508205
46MP0003121_genomic_imprinting1.25515162
47MP0002751_abnormal_autonomic_nervous1.24253805
48MP0000566_synostosis1.23081264
49MP0005253_abnormal_eye_physiology1.23071782
50MP0002019_abnormal_tumor_incidence1.22141833
51MP0005171_absent_coat_pigmentation1.21201370
52MP0009333_abnormal_splenocyte_physiolog1.21108551
53MP0003699_abnormal_female_reproductive1.18292430
54MP0005389_reproductive_system_phenotype1.16781714
55MP0005451_abnormal_body_composition1.16755101
56MP0002233_abnormal_nose_morphology1.16589801
57MP0001529_abnormal_vocalization1.15379427
58MP0002160_abnormal_reproductive_system1.15140478
59MP0001188_hyperpigmentation1.14876634
60MP0002234_abnormal_pharynx_morphology1.07943436
61MP0000631_abnormal_neuroendocrine_gland1.05214082
62MP0003698_abnormal_male_reproductive1.05099652
63MP0003890_abnormal_embryonic-extraembry1.04578812
64MP0002086_abnormal_extraembryonic_tissu1.04406081
65MP0002837_dystrophic_cardiac_calcinosis1.03670029
66MP0002736_abnormal_nociception_after1.03100534
67MP0002161_abnormal_fertility/fecundity1.01798904
68MP0005551_abnormal_eye_electrophysiolog1.01316234
69MP0003122_maternal_imprinting1.00798096
70MP0006035_abnormal_mitochondrial_morpho1.00203843
71MP0005084_abnormal_gallbladder_morpholo0.99475871
72MP0000427_abnormal_hair_cycle0.99179969
73MP0002254_reproductive_system_inflammat0.96739831
74MP0001293_anophthalmia0.96663792
75MP0001984_abnormal_olfaction0.95500602
76MP0008789_abnormal_olfactory_epithelium0.94456831
77MP0001919_abnormal_reproductive_system0.94406252
78MP0010030_abnormal_orbit_morphology0.93765947
79MP0005408_hypopigmentation0.92630487
80MP0003755_abnormal_palate_morphology0.92223166
81MP0000647_abnormal_sebaceous_gland0.91947967
82MP0000049_abnormal_middle_ear0.91423221
83MP0003186_abnormal_redox_activity0.90824293
84MP0003787_abnormal_imprinting0.90814353
85MP0004215_abnormal_myocardial_fiber0.89011817
86MP0008995_early_reproductive_senescence0.87866155
87MP0003119_abnormal_digestive_system0.87460206
88MP0003646_muscle_fatigue0.86466778
89MP0004197_abnormal_fetal_growth/weight/0.82985438
90MP0000358_abnormal_cell_content/0.82911396
91MP0002090_abnormal_vision0.82566306
92MP0003567_abnormal_fetal_cardiomyocyte0.82402712
93MP0005377_hearing/vestibular/ear_phenot0.81146786
94MP0003878_abnormal_ear_physiology0.81146786
95MP0002638_abnormal_pupillary_reflex0.80898802
96MP0006054_spinal_hemorrhage0.80320273
97MP0004147_increased_porphyrin_level0.80113329
98MP0010352_gastrointestinal_tract_polyps0.79677817
99MP0001177_atelectasis0.78393575
100MP0002282_abnormal_trachea_morphology0.77542523
101MP0005384_cellular_phenotype0.76527598
102MP0009672_abnormal_birth_weight0.74095525
103MP0005621_abnormal_cell_physiology0.73851755
104MP0004133_heterotaxia0.73122498
105MP0008875_abnormal_xenobiotic_pharmacok0.72815811
106MP0003137_abnormal_impulse_conducting0.71974533
107MP0004808_abnormal_hematopoietic_stem0.70131505
108MP0003938_abnormal_ear_development0.65434493
109MP0003936_abnormal_reproductive_system0.65044136
110MP0003221_abnormal_cardiomyocyte_apopto0.62629723
111MP0005397_hematopoietic_system_phenotyp0.62362108
112MP0001545_abnormal_hematopoietic_system0.62362108
113MP0003950_abnormal_plasma_membrane0.62043157
114MP0002111_abnormal_tail_morphology0.61055733
115MP0002132_abnormal_respiratory_system0.59410733
116MP0001905_abnormal_dopamine_level0.58462226
117MP0003861_abnormal_nervous_system0.57598776
118MP0001485_abnormal_pinna_reflex0.57530578
119MP0000703_abnormal_thymus_morphology0.57285415
120MP0003763_abnormal_thymus_physiology0.56936584
121MP0001286_abnormal_eye_development0.55589966
122MP0005499_abnormal_olfactory_system0.55413655
123MP0005394_taste/olfaction_phenotype0.55413655
124MP0006036_abnormal_mitochondrial_physio0.55031727
125MP0002163_abnormal_gland_morphology0.54597239
126MP0000627_abnormal_mammary_gland0.54462912
127MP0000383_abnormal_hair_follicle0.53879743
128MP0002092_abnormal_eye_morphology0.53791168
129MP0003656_abnormal_erythrocyte_physiolo0.53033900
130MP0009703_decreased_birth_body0.52799727
131MP0005391_vision/eye_phenotype0.52442173
132MP0002938_white_spotting0.52029033
133MP0005410_abnormal_fertilization0.50910247
134MP0000858_altered_metastatic_potential0.50876495
135MP0003136_yellow_coat_color0.50779758

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.81826674
2Breast hypoplasia (HP:0003187)5.79681790
3Cerebral hypomyelination (HP:0006808)4.50992009
4Carpal bone hypoplasia (HP:0001498)4.09845376
5Patellar aplasia (HP:0006443)3.95566422
6Degeneration of anterior horn cells (HP:0002398)3.94172236
7Abnormality of the anterior horn cell (HP:0006802)3.94172236
8Aplasia/Hypoplasia of the patella (HP:0006498)3.81218543
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.59074654
10Chromsome breakage (HP:0040012)3.54728449
11Abnormality of the labia minora (HP:0012880)3.36338721
12Secondary amenorrhea (HP:0000869)3.30201600
13Impulsivity (HP:0100710)3.24378605
14Premature ovarian failure (HP:0008209)3.14440978
15Oral leukoplakia (HP:0002745)3.13927032
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.12256527
17Rough bone trabeculation (HP:0100670)3.11237535
18Absent radius (HP:0003974)3.07608404
19Abnormality of the preputium (HP:0100587)2.99358662
20Aplasia involving forearm bones (HP:0009822)2.92922228
21Absent forearm bone (HP:0003953)2.92922228
22Microretrognathia (HP:0000308)2.91811498
23Supernumerary spleens (HP:0009799)2.91059332
24Abnormality of cells of the erythroid lineage (HP:0012130)2.88097347
25Meckel diverticulum (HP:0002245)2.88041443
26CNS hypomyelination (HP:0003429)2.80490479
27Abnormality of chromosome stability (HP:0003220)2.77946229
28Abnormal number of erythroid precursors (HP:0012131)2.76240773
29Male infertility (HP:0003251)2.75075780
30Horseshoe kidney (HP:0000085)2.74477067
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.70981379
32Abnormality of the ileum (HP:0001549)2.69415002
33Reticulocytopenia (HP:0001896)2.67398143
34Abnormality of midbrain morphology (HP:0002418)2.65906956
35Molar tooth sign on MRI (HP:0002419)2.65906956
36Increased hepatocellular lipid droplets (HP:0006565)2.64650912
37Small intestinal stenosis (HP:0012848)2.64586175
38Duodenal stenosis (HP:0100867)2.64586175
39Abnormal lung lobation (HP:0002101)2.64573712
40Aplastic anemia (HP:0001915)2.63859748
41Septo-optic dysplasia (HP:0100842)2.54862448
42Colon cancer (HP:0003003)2.51961929
43Acute necrotizing encephalopathy (HP:0006965)2.48985017
44Facial hemangioma (HP:0000329)2.48200923
45Absent thumb (HP:0009777)2.47278381
46Aplasia/Hypoplasia of the sternum (HP:0006714)2.44433820
47Hypoplasia of the capital femoral epiphysis (HP:0003090)2.42987372
48Acute encephalopathy (HP:0006846)2.41292236
49Increased CSF lactate (HP:0002490)2.41143407
50Methylmalonic acidemia (HP:0002912)2.40983161
51Sloping forehead (HP:0000340)2.37314647
52Lipid accumulation in hepatocytes (HP:0006561)2.37014052
53Pancreatic fibrosis (HP:0100732)2.35352574
54Atrophy/Degeneration involving motor neurons (HP:0007373)2.34872654
55Aplasia/Hypoplasia of the breasts (HP:0010311)2.33588938
56Hyperglycinemia (HP:0002154)2.33230663
57Stenosis of the external auditory canal (HP:0000402)2.33137821
58Selective tooth agenesis (HP:0001592)2.33053265
59Breast aplasia (HP:0100783)2.32044004
60Abnormal trabecular bone morphology (HP:0100671)2.31922154
61Bone marrow hypocellularity (HP:0005528)2.29702613
62Myelodysplasia (HP:0002863)2.27746006
63Nephroblastoma (Wilms tumor) (HP:0002667)2.27362798
64Ependymoma (HP:0002888)2.26346971
65Volvulus (HP:0002580)2.21825460
66Rhabdomyosarcoma (HP:0002859)2.20147513
67True hermaphroditism (HP:0010459)2.19940948
68Ureteral duplication (HP:0000073)2.19529097
69Ectopic kidney (HP:0000086)2.19020338
70Nephronophthisis (HP:0000090)2.17694183
71Premature graying of hair (HP:0002216)2.16975541
72Mitochondrial inheritance (HP:0001427)2.16894460
73Progressive macrocephaly (HP:0004481)2.16327155
74Pancreatic cysts (HP:0001737)2.16078384
75Clubbing of toes (HP:0100760)2.15240065
76Embryonal renal neoplasm (HP:0011794)2.15183046
77Abnormality of the duodenum (HP:0002246)2.12248885
78Glioma (HP:0009733)2.11339299
79Abnormal mitochondria in muscle tissue (HP:0008316)2.11103280
80Atresia of the external auditory canal (HP:0000413)2.10412458
81Abnormal spermatogenesis (HP:0008669)2.09214248
82Postnatal microcephaly (HP:0005484)2.07898454
83Adrenal hypoplasia (HP:0000835)2.07150780
84Duplicated collecting system (HP:0000081)2.06241862
85Pancreatic islet-cell hyperplasia (HP:0004510)2.06099258
86Aplasia/Hypoplasia involving the musculature (HP:0001460)2.05884483
87Abnormality of the carotid arteries (HP:0005344)2.05829884
88Neoplasm of the pancreas (HP:0002894)2.05189987
89Absent septum pellucidum (HP:0001331)2.04622279
90Capillary hemangiomas (HP:0005306)2.04555863
91Cleft eyelid (HP:0000625)2.04510505
92Cellular immunodeficiency (HP:0005374)2.04116169
93Abnormality of alanine metabolism (HP:0010916)2.03869281
94Hyperalaninemia (HP:0003348)2.03869281
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03869281
96Squamous cell carcinoma (HP:0002860)2.03274785
97Triphalangeal thumb (HP:0001199)2.03097474
98Abnormality of the pons (HP:0007361)2.02931434
99Medulloblastoma (HP:0002885)2.02259739
100Short thumb (HP:0009778)2.01542974
101Increased serum lactate (HP:0002151)2.01465769
102Abnormality of serum amino acid levels (HP:0003112)2.00992656
103Slender long bone (HP:0003100)2.00769827
104Hypoplasia of the pons (HP:0012110)1.99701885
105Delusions (HP:0000746)1.99387128
106Abnormality of the septum pellucidum (HP:0007375)1.98102540
107Personality changes (HP:0000751)1.97863464
108Medial flaring of the eyebrow (HP:0010747)1.97578110
109Methylmalonic aciduria (HP:0012120)1.95828907
110Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95670744
111Abnormality of glycine metabolism (HP:0010895)1.95149495
112Abnormality of serine family amino acid metabolism (HP:0010894)1.95149495
113Neoplasm of the colon (HP:0100273)1.95080874
114Hyperglycinuria (HP:0003108)1.93873213
115Irregular epiphyses (HP:0010582)1.93261678
116Hepatocellular necrosis (HP:0001404)1.92399662
117Type 2 muscle fiber atrophy (HP:0003554)1.91017053
118Optic nerve hypoplasia (HP:0000609)1.90910938
119Unsteady gait (HP:0002317)1.90012629
120Median cleft lip (HP:0000161)1.88763585
121Type I transferrin isoform profile (HP:0003642)1.88287977
122Hepatic necrosis (HP:0002605)1.88002139
123Aplasia/Hypoplasia of the tongue (HP:0010295)1.87983912
124Abnormality of methionine metabolism (HP:0010901)1.87694131
125Biliary tract neoplasm (HP:0100574)1.87634082
126Trismus (HP:0000211)1.86944932
127Abnormal biliary tract physiology (HP:0012439)1.86692185
128Bile duct proliferation (HP:0001408)1.86692185
129Pendular nystagmus (HP:0012043)1.85968247
130Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85827178
131Facial cleft (HP:0002006)1.85219263
132Oligodactyly (HP:0012165)1.84035371
133Abnormality of the umbilical cord (HP:0010881)1.83465940
134Abnormality of the renal collecting system (HP:0004742)1.82918413
135Macrocytic anemia (HP:0001972)1.81171042
136Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.80677517
137Decreased activity of mitochondrial respiratory chain (HP:0008972)1.80677517
138Spinal muscular atrophy (HP:0007269)1.80542807
139Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80236166
140Absent epiphyses (HP:0010577)1.80236166
141Sparse eyelashes (HP:0000653)1.79842859
142Hypothermia (HP:0002045)1.79358529
143Abnormality of the heme biosynthetic pathway (HP:0010472)1.78520745
144Overlapping toe (HP:0001845)1.77431775
145Neoplasm of the adrenal gland (HP:0100631)1.76403895
146Abnormal protein glycosylation (HP:0012346)1.76324159
147Abnormal glycosylation (HP:0012345)1.76324159
148Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76324159
149Abnormal protein N-linked glycosylation (HP:0012347)1.76324159
150Megaloblastic anemia (HP:0001889)1.76296444
151Hypoplasia of the radius (HP:0002984)1.75581450
152Dandy-Walker malformation (HP:0001305)1.75446245
153Muscle fiber atrophy (HP:0100295)1.75364989
154Shawl scrotum (HP:0000049)1.75162380
155Abnormality of the clitoris (HP:0000056)1.75015776
156Abnormality of the renal medulla (HP:0100957)1.74983756
157Bifid tongue (HP:0010297)1.74092778
158Increased serum pyruvate (HP:0003542)1.71732282
159Cerebral edema (HP:0002181)1.71561255
160Neoplasm of the adrenal cortex (HP:0100641)1.71298908
161Preaxial hand polydactyly (HP:0001177)1.70533723
162Lactic acidosis (HP:0003128)1.69264901
163Congenital primary aphakia (HP:0007707)1.68568910
164Abnormality of the astrocytes (HP:0100707)1.67200335
165Astrocytoma (HP:0009592)1.67200335
166Genital tract atresia (HP:0001827)1.66400253

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.45932216
2WEE14.27271291
3EIF2AK13.64448313
4CDC73.58861381
5TRIM283.26286767
6PLK43.10460968
7SRPK12.90273675
8NEK22.80957335
9TTK2.73873748
10VRK12.34436148
11BRSK22.32922199
12STK162.31093506
13PLK12.29838889
14PLK32.13031871
15EIF2AK32.10462858
16VRK22.08693115
17WNK32.04296045
18NME21.91971628
19TNIK1.81161540
20DYRK31.80605885
21CHEK21.77010744
22MKNK11.76921480
23FRK1.72660826
24TSSK61.71880867
25BMPR1B1.71426093
26PNCK1.69936742
27AURKB1.68172219
28MOS1.67482989
29NEK11.65676592
30ACVR1B1.64301431
31MKNK21.62723280
32AURKA1.61215076
33STK38L1.52229204
34LATS21.46409255
35BCR1.44949366
36BRSK11.44430556
37TESK21.44224651
38BRAF1.42311423
39LATS11.41472497
40TAF11.41357418
41DYRK21.37756662
42PASK1.33316256
43STK101.31646444
44CDK71.25905310
45EIF2AK21.22168196
46ATR1.17585203
47CDK81.16992860
48MAP3K81.16346358
49EPHA21.16273875
50RPS6KA41.13347265
51STK391.13128925
52CCNB11.11685414
53BMPR21.06182045
54MAP3K61.03935725
55CHEK11.03248508
56MAP4K21.03094133
57CDK40.99109378
58CASK0.89058100
59STK30.87780087
60ARAF0.86642957
61GRK10.86594421
62TLK10.85637832
63MELK0.78933662
64OXSR10.74624318
65MST40.74497154
66PDK40.73637938
67PDK30.73637938
68PBK0.72891327
69MAP3K40.71565705
70ZAK0.71452014
71NME10.71124661
72CDK20.70950637
73PAK30.70696343
74INSRR0.70504870
75RPS6KB20.70108178
76PAK10.69568412
77ATM0.69432670
78ERBB30.68260781
79CSNK1G10.67615987
80CSNK1G30.66594572
81PRKCI0.66531808
82ADRBK20.65942346
83WNK40.62507059
84CDK10.61746353
85CSNK2A10.61272745
86CSNK2A20.54582069
87SIK30.53919023
88PDK20.51881579
89NLK0.51670183
90MINK10.49369364
91STK40.47312910
92TGFBR10.46237478
93BCKDK0.44515151
94CDK30.44028214
95RPS6KA50.43632065
96PAK40.43043917
97PRKCG0.41468627
98ERBB40.39887046
99CSNK1A1L0.39259387
100ABL20.38119167
101FGFR10.37924460
102AKT30.37398728
103CSNK1G20.35894478
104CDK190.35206908
105MAP3K120.34554396
106RAF10.34545232
107PINK10.34338189
108MAP2K70.34311922
109CSNK1E0.33658646
110PRKCE0.33219282
111PKN10.32055928
112DYRK1A0.31042509
113CSNK1A10.30920761
114PIM10.30838667
115MAPKAPK30.29315624
116STK240.27161756
117NUAK10.23978550
118PLK20.22869583
119SCYL20.20153158
120CDK90.19820662
121ALK0.19741187
122CDK11A0.18516023
123MUSK0.18255867
124PRKDC0.18175344
125CDK150.17758185
126BRD40.17259276
127CDK180.16724611
128MAPK90.16115834
129MAPK130.15766365
130MARK30.14150977

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.32826296
2DNA replication_Homo sapiens_hsa030304.25555195
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.24501964
4Mismatch repair_Homo sapiens_hsa034303.68547785
5Proteasome_Homo sapiens_hsa030503.65817026
6* RNA transport_Homo sapiens_hsa030133.39304418
7Cell cycle_Homo sapiens_hsa041103.19146814
8Spliceosome_Homo sapiens_hsa030403.09609310
9Basal transcription factors_Homo sapiens_hsa030223.08772295
10Nucleotide excision repair_Homo sapiens_hsa034202.99559736
11Homologous recombination_Homo sapiens_hsa034402.89701718
12Vitamin B6 metabolism_Homo sapiens_hsa007502.77244118
13Pyrimidine metabolism_Homo sapiens_hsa002402.74566370
14Base excision repair_Homo sapiens_hsa034102.67822914
15Ribosome_Homo sapiens_hsa030102.62838792
16Fanconi anemia pathway_Homo sapiens_hsa034602.31860798
17RNA degradation_Homo sapiens_hsa030182.26993811
18Propanoate metabolism_Homo sapiens_hsa006402.03393406
19One carbon pool by folate_Homo sapiens_hsa006701.99461786
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97152158
21Non-homologous end-joining_Homo sapiens_hsa034501.91301965
22mRNA surveillance pathway_Homo sapiens_hsa030151.77818093
23p53 signaling pathway_Homo sapiens_hsa041151.76983793
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73131720
25Purine metabolism_Homo sapiens_hsa002301.72869668
26Oocyte meiosis_Homo sapiens_hsa041141.65853597
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49548485
28Pyruvate metabolism_Homo sapiens_hsa006201.45355898
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35760357
30Fatty acid elongation_Homo sapiens_hsa000621.32468567
31Protein export_Homo sapiens_hsa030601.31059521
32Steroid biosynthesis_Homo sapiens_hsa001001.27433434
33Folate biosynthesis_Homo sapiens_hsa007901.24151022
34Epstein-Barr virus infection_Homo sapiens_hsa051691.22299503
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11504547
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.10341026
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95688160
38Butanoate metabolism_Homo sapiens_hsa006500.95420424
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90535799
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88590263
41Regulation of autophagy_Homo sapiens_hsa041400.85859994
42Alzheimers disease_Homo sapiens_hsa050100.82956516
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82880808
44Systemic lupus erythematosus_Homo sapiens_hsa053220.79877406
45Huntingtons disease_Homo sapiens_hsa050160.74038276
46Caffeine metabolism_Homo sapiens_hsa002320.72960499
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72072599
48Viral carcinogenesis_Homo sapiens_hsa052030.71405052
49Sulfur relay system_Homo sapiens_hsa041220.70925758
50Pentose phosphate pathway_Homo sapiens_hsa000300.69653453
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.67376130
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64711790
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64188467
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63585236
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63344752
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63248709
57Sulfur metabolism_Homo sapiens_hsa009200.62725774
58Herpes simplex infection_Homo sapiens_hsa051680.61328062
59Selenocompound metabolism_Homo sapiens_hsa004500.59621091
60Biosynthesis of amino acids_Homo sapiens_hsa012300.58842366
61Nicotine addiction_Homo sapiens_hsa050330.58656657
62Nitrogen metabolism_Homo sapiens_hsa009100.55242417
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55017202
64Tryptophan metabolism_Homo sapiens_hsa003800.54940378
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53084378
66HTLV-I infection_Homo sapiens_hsa051660.52860821
67Linoleic acid metabolism_Homo sapiens_hsa005910.51013979
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50632553
69Peroxisome_Homo sapiens_hsa041460.50394214
70Glutathione metabolism_Homo sapiens_hsa004800.49913205
71Circadian rhythm_Homo sapiens_hsa047100.49320236
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49131559
73Fatty acid metabolism_Homo sapiens_hsa012120.48682513
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47554772
75Taste transduction_Homo sapiens_hsa047420.47506272
76MicroRNAs in cancer_Homo sapiens_hsa052060.46494083
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45964781
78Antigen processing and presentation_Homo sapiens_hsa046120.45163655
79beta-Alanine metabolism_Homo sapiens_hsa004100.45066321
80Thyroid cancer_Homo sapiens_hsa052160.44432091
81TGF-beta signaling pathway_Homo sapiens_hsa043500.43226672
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41321116
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40919391
84Retinol metabolism_Homo sapiens_hsa008300.39774586
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39481759
86Hippo signaling pathway_Homo sapiens_hsa043900.37783659
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37604525
88Ether lipid metabolism_Homo sapiens_hsa005650.37546844
89Alcoholism_Homo sapiens_hsa050340.36959846
90Phototransduction_Homo sapiens_hsa047440.36068433
91Olfactory transduction_Homo sapiens_hsa047400.35269249
92Metabolic pathways_Homo sapiens_hsa011000.34245840
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.33531298
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.33006438
95Cardiac muscle contraction_Homo sapiens_hsa042600.32282694
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31756019
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.31306033
98Small cell lung cancer_Homo sapiens_hsa052220.31072791
99Fatty acid degradation_Homo sapiens_hsa000710.31022641
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29903160
101Arachidonic acid metabolism_Homo sapiens_hsa005900.28313703
102Parkinsons disease_Homo sapiens_hsa050120.28113266
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26757425
104N-Glycan biosynthesis_Homo sapiens_hsa005100.26580810
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25685278
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24905529
107Hedgehog signaling pathway_Homo sapiens_hsa043400.24837426
108Oxidative phosphorylation_Homo sapiens_hsa001900.24032867
109Chemical carcinogenesis_Homo sapiens_hsa052040.22976216
110Vitamin digestion and absorption_Homo sapiens_hsa049770.22908962
111Sphingolipid metabolism_Homo sapiens_hsa006000.22413957
112Fructose and mannose metabolism_Homo sapiens_hsa000510.20955294
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.20489859
114Colorectal cancer_Homo sapiens_hsa052100.20380164
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16059433
116Ovarian steroidogenesis_Homo sapiens_hsa049130.14017631
117Arginine and proline metabolism_Homo sapiens_hsa003300.13013521
118Basal cell carcinoma_Homo sapiens_hsa052170.11458333
119Apoptosis_Homo sapiens_hsa042100.10513360
120Bladder cancer_Homo sapiens_hsa052190.09962738
121Shigellosis_Homo sapiens_hsa051310.08573190
122Carbon metabolism_Homo sapiens_hsa012000.07829327
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.07772654
124FoxO signaling pathway_Homo sapiens_hsa040680.07132623
125Wnt signaling pathway_Homo sapiens_hsa043100.06342106
126Pathways in cancer_Homo sapiens_hsa052000.05891671
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.04509310
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.02773282
129Prostate cancer_Homo sapiens_hsa052150.02750163
130Hepatitis B_Homo sapiens_hsa051610.01989633
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.01802128
132Legionellosis_Homo sapiens_hsa05134-0.0398281
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210-0.0345900
134Tight junction_Homo sapiens_hsa04530-0.0273373
135Notch signaling pathway_Homo sapiens_hsa04330-0.0167272
136Pancreatic cancer_Homo sapiens_hsa05212-0.0164118
137SNARE interactions in vesicular transport_Homo sapiens_hsa04130-0.0050877

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