NUP37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nuclear pore complexes (NPCs) are used for transporting macromolecules between the cytoplasm and the nucleus. NPCs consist of multiple copies of 30 distinct proteins (nucleoporins), which assemble into biochemically-separable subcomplexes. The protein encoded by this gene is part of a subcomplex (Nup107-160) that is required for proper NPC function as well as for normal kinetochore-microtubule interaction and mitosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.93278877
2DNA strand elongation involved in DNA replication (GO:0006271)4.84460315
3CENP-A containing nucleosome assembly (GO:0034080)4.79269567
4chromatin remodeling at centromere (GO:0031055)4.67123868
5telomere maintenance via semi-conservative replication (GO:0032201)4.66912464
6DNA strand elongation (GO:0022616)4.63370719
7protein localization to kinetochore (GO:0034501)4.57190276
8DNA replication initiation (GO:0006270)4.54431227
9DNA replication checkpoint (GO:0000076)4.38170685
10metaphase plate congression (GO:0051310)4.36619778
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.36076841
12nucleobase biosynthetic process (GO:0046112)4.28763585
13telomere maintenance via recombination (GO:0000722)4.26542223
14kinetochore organization (GO:0051383)4.25245143
15ribosomal small subunit assembly (GO:0000028)4.23922289
16maturation of SSU-rRNA (GO:0030490)4.20270764
17DNA replication-independent nucleosome assembly (GO:0006336)4.18837034
18DNA replication-independent nucleosome organization (GO:0034724)4.18837034
19DNA unwinding involved in DNA replication (GO:0006268)4.15075089
20attachment of spindle microtubules to kinetochore (GO:0008608)4.13225541
21formation of translation preinitiation complex (GO:0001731)4.12075595
22mitotic recombination (GO:0006312)4.07856537
23establishment of chromosome localization (GO:0051303)4.01359627
24DNA deamination (GO:0045006)4.00819876
25purine nucleobase biosynthetic process (GO:0009113)4.00178485
26protein localization to chromosome, centromeric region (GO:0071459)3.99657935
27histone exchange (GO:0043486)3.95680944
28kinetochore assembly (GO:0051382)3.93116552
29telomere maintenance via telomere lengthening (GO:0010833)3.86518837
30mitotic chromosome condensation (GO:0007076)3.83817757
31* mitotic nuclear envelope disassembly (GO:0007077)3.83382062
32DNA ligation (GO:0006266)3.82431623
33regulation of spindle organization (GO:0090224)3.81458503
34mitotic sister chromatid segregation (GO:0000070)3.80525052
35DNA replication-dependent nucleosome organization (GO:0034723)3.78955419
36DNA replication-dependent nucleosome assembly (GO:0006335)3.78955419
37ribosome assembly (GO:0042255)3.68710638
38ribosomal large subunit biogenesis (GO:0042273)3.68002171
39DNA double-strand break processing (GO:0000729)3.65894665
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.65888786
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.65224324
42ATP synthesis coupled proton transport (GO:0015986)3.65224324
43nucleotide-excision repair, DNA gap filling (GO:0006297)3.60610219
44ribosome biogenesis (GO:0042254)3.56137095
45chaperone-mediated protein transport (GO:0072321)3.53951631
46IMP biosynthetic process (GO:0006188)3.52993022
47ribonucleoprotein complex biogenesis (GO:0022613)3.52929348
48protein K6-linked ubiquitination (GO:0085020)3.52460093
49* membrane disassembly (GO:0030397)3.52401717
50* nuclear envelope disassembly (GO:0051081)3.52401717
51folic acid-containing compound biosynthetic process (GO:0009396)3.50538603
52viral transcription (GO:0019083)3.48258735
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.48051698
54translational termination (GO:0006415)3.47343087
55ribosomal small subunit biogenesis (GO:0042274)3.44104074
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.43473156
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.42728068
58spindle checkpoint (GO:0031577)3.42393329
59sister chromatid segregation (GO:0000819)3.39345866
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36530987
61meiotic chromosome segregation (GO:0045132)3.35919849
62spliceosomal snRNP assembly (GO:0000387)3.34992994
63proteasome assembly (GO:0043248)3.34951699
64rRNA processing (GO:0006364)3.34408879
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31829066
66regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.30538936
67regulation of mitotic spindle checkpoint (GO:1903504)3.30538936
68negative regulation of chromosome segregation (GO:0051985)3.30475928
69negative regulation of mitotic sister chromatid segregation (GO:0033048)3.30320506
70negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.30320506
71negative regulation of sister chromatid segregation (GO:0033046)3.30320506
72negative regulation of mitotic sister chromatid separation (GO:2000816)3.30320506
73transcription-coupled nucleotide-excision repair (GO:0006283)3.30054667
74regulation of mitotic spindle organization (GO:0060236)3.29277285
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.28018586
76negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.27875882
77DNA catabolic process, exonucleolytic (GO:0000738)3.27699523
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27227569
79rRNA modification (GO:0000154)3.27177430
80translational initiation (GO:0006413)3.26247792
81nuclear pore organization (GO:0006999)3.24299671
82spindle assembly checkpoint (GO:0071173)3.24067452
83translational elongation (GO:0006414)3.23699203
84rRNA metabolic process (GO:0016072)3.23454692
85IMP metabolic process (GO:0046040)3.22991178
86cullin deneddylation (GO:0010388)3.21194581
87mitotic spindle assembly checkpoint (GO:0007094)3.20587277
88establishment of integrated proviral latency (GO:0075713)3.20469608
89regulation of chromosome segregation (GO:0051983)3.20392852
90regulation of double-strand break repair via homologous recombination (GO:0010569)3.18710876
91establishment of viral latency (GO:0019043)3.18428429
92mitotic spindle checkpoint (GO:0071174)3.18223438
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17872682
94replication fork processing (GO:0031297)3.16200290
95regulation of mitotic metaphase/anaphase transition (GO:0030071)3.15079190
96maturation of 5.8S rRNA (GO:0000460)3.14766503
97positive regulation of ligase activity (GO:0051351)3.14021158
98positive regulation of chromosome segregation (GO:0051984)3.14010261
99deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13824024
100G1/S transition of mitotic cell cycle (GO:0000082)3.13707058
101cell cycle G1/S phase transition (GO:0044843)3.13707058
102regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13536555
103nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13458713
104pseudouridine synthesis (GO:0001522)3.12799709
105signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.11338136
106signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.11338136
107signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.11338136
108DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10438377
109regulation of centriole replication (GO:0046599)3.10334999
110intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.08487803
111signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.08487803
112regulation of mitochondrial translation (GO:0070129)3.07827063
113chromatin assembly or disassembly (GO:0006333)3.07127423
114synapsis (GO:0007129)3.06228990
115telomere maintenance (GO:0000723)3.06221380
116telomere organization (GO:0032200)3.05796447
117regulation of cellular amino acid metabolic process (GO:0006521)3.05218932
118regulation of ubiquitin-protein transferase activity (GO:0051438)3.04984992
119rRNA methylation (GO:0031167)3.03765312
120* chromosome segregation (GO:0007059)3.02901795
121spliceosomal complex assembly (GO:0000245)3.02824576
122signal transduction involved in DNA damage checkpoint (GO:0072422)3.02384077
123signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02384077
124double-strand break repair via nonhomologous end joining (GO:0006303)3.02127529
125non-recombinational repair (GO:0000726)3.02127529
126SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.01409789
127regulation of sister chromatid segregation (GO:0033045)3.01295291
128regulation of mitotic sister chromatid separation (GO:0010965)3.01295291
129regulation of mitotic sister chromatid segregation (GO:0033047)3.01295291
130negative regulation of ligase activity (GO:0051352)3.00999662
131negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00999662
132somatic hypermutation of immunoglobulin genes (GO:0016446)3.00432920
133somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00432920
134nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.99988654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.37541113
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.54655599
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.37891398
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.92063299
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.69734147
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.52543667
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.49512161
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.24889266
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.12507502
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00869647
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00615404
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91100016
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.88890770
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88659864
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77019143
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56565680
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44842075
18AR_21909140_ChIP-Seq_LNCAP_Human2.43186610
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42642543
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.37730050
21XRN2_22483619_ChIP-Seq_HELA_Human2.34717042
22VDR_23849224_ChIP-Seq_CD4+_Human2.33200708
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32413172
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13418876
25DCP1A_22483619_ChIP-Seq_HELA_Human2.09766551
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06847909
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05988552
28FOXP3_21729870_ChIP-Seq_TREG_Human2.05581086
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98401761
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.98187658
31* GABP_19822575_ChIP-Seq_HepG2_Human1.89043840
32TTF2_22483619_ChIP-Seq_HELA_Human1.88457145
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88044519
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86062354
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84363998
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80449653
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79094959
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78879314
39ELK1_19687146_ChIP-ChIP_HELA_Human1.75341582
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75255120
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73665466
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71432598
43* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70374410
44* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69819631
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63323045
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.59679131
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58847191
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58178215
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.58055385
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52713815
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52402091
52CIITA_25753668_ChIP-Seq_RAJI_Human1.52050551
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.48584164
54* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47881153
55EWS_26573619_Chip-Seq_HEK293_Human1.42075988
56KDM5A_27292631_Chip-Seq_BREAST_Human1.36975501
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32697462
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28376434
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27627331
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26349804
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25002108
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24479707
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23410389
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19118479
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18665412
66* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18392538
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13974407
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13263905
69ZNF274_21170338_ChIP-Seq_K562_Hela1.12375012
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12207409
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.11381110
72MYC_22102868_ChIP-Seq_BL_Human1.11297996
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09951900
74FUS_26573619_Chip-Seq_HEK293_Human1.09446612
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08764363
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07042448
77VDR_22108803_ChIP-Seq_LS180_Human1.06069409
78MYC_18940864_ChIP-ChIP_HL60_Human1.05927915
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05099305
80TFEB_21752829_ChIP-Seq_HELA_Human1.02809427
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02453321
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99043917
83NOTCH1_21737748_ChIP-Seq_TLL_Human0.98954103
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98382886
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97558035
86TP63_19390658_ChIP-ChIP_HaCaT_Human0.96823095
87SOX2_16153702_ChIP-ChIP_HESCs_Human0.96190148
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96183979
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96003385
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95012873
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92764827
92* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92032463
93IRF1_19129219_ChIP-ChIP_H3396_Human0.91926351
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91906373
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.89419883
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88789392
97* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87809999
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.86704849
99* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86553374
100SPI1_23547873_ChIP-Seq_NB4_Human0.86425831
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82677000
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82404503
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79570675
104NANOG_21062744_ChIP-ChIP_HESCs_Human0.77613729
105SALL1_21062744_ChIP-ChIP_HESCs_Human0.76306807
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75700133
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75604766
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74849199
109SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74264837
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.74087577
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73913338
112IGF1R_20145208_ChIP-Seq_DFB_Human0.71882543
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71420299
114SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70947790
115SOX17_20123909_ChIP-Seq_XEN_Mouse0.70250066
116POU3F2_20337985_ChIP-ChIP_501MEL_Human0.68429369
117ELF5_23300383_ChIP-Seq_T47D_Human0.67020448
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.66725520
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.63108274
120PCGF2_27294783_Chip-Seq_ESCs_Mouse0.61636353
121NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.60565231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.18866844
2MP0010094_abnormal_chromosome_stability5.09199046
3MP0004957_abnormal_blastocyst_morpholog4.86944257
4MP0003111_abnormal_nucleus_morphology4.83524215
5MP0003077_abnormal_cell_cycle4.42457939
6MP0008057_abnormal_DNA_replication4.18642295
7MP0008058_abnormal_DNA_repair3.78440400
8MP0008007_abnormal_cellular_replicative3.16903677
9MP0008932_abnormal_embryonic_tissue2.86909734
10MP0003123_paternal_imprinting2.66248808
11MP0002396_abnormal_hematopoietic_system2.45309389
12MP0001730_embryonic_growth_arrest2.33631759
13MP0008877_abnormal_DNA_methylation2.32184699
14MP0003718_maternal_effect2.28053980
15MP0000350_abnormal_cell_proliferation2.21798759
16MP0003786_premature_aging2.12059901
17MP0010352_gastrointestinal_tract_polyps1.86851532
18MP0003806_abnormal_nucleotide_metabolis1.84703244
19MP0000372_irregular_coat_pigmentation1.78522413
20MP0010307_abnormal_tumor_latency1.75088706
21MP0000490_abnormal_crypts_of1.70299077
22MP0001529_abnormal_vocalization1.69072369
23MP0001697_abnormal_embryo_size1.68590202
24MP0005380_embryogenesis_phenotype1.63838962
25MP0001672_abnormal_embryogenesis/_devel1.63838962
26MP0008789_abnormal_olfactory_epithelium1.59185960
27MP0002080_prenatal_lethality1.53883597
28MP0002019_abnormal_tumor_incidence1.50532319
29MP0006072_abnormal_retinal_apoptosis1.50285673
30MP0000313_abnormal_cell_death1.48100940
31MP0003136_yellow_coat_color1.47119631
32MP0003950_abnormal_plasma_membrane1.42466427
33MP0003984_embryonic_growth_retardation1.41864631
34MP0002085_abnormal_embryonic_tissue1.41669068
35MP0002210_abnormal_sex_determination1.41483520
36MP0002088_abnormal_embryonic_growth/wei1.37852752
37MP0004808_abnormal_hematopoietic_stem1.35541643
38MP0003186_abnormal_redox_activity1.30990675
39MP0006292_abnormal_olfactory_placode1.30385901
40MP0003315_abnormal_perineum_morphology1.26075217
41MP0009333_abnormal_splenocyte_physiolog1.24090931
42MP0002084_abnormal_developmental_patter1.23967762
43MP0001145_abnormal_male_reproductive1.22448078
44MP0002086_abnormal_extraembryonic_tissu1.22320859
45MP0003567_abnormal_fetal_cardiomyocyte1.21133853
46MP0003763_abnormal_thymus_physiology1.20148719
47MP0001929_abnormal_gametogenesis1.19400223
48MP0003121_genomic_imprinting1.18757557
49MP0010030_abnormal_orbit_morphology1.18587255
50MP0008995_early_reproductive_senescence1.16662884
51MP0000653_abnormal_sex_gland1.13022556
52MP0005397_hematopoietic_system_phenotyp1.08781473
53MP0001545_abnormal_hematopoietic_system1.08781473
54MP0005394_taste/olfaction_phenotype1.06872986
55MP0005499_abnormal_olfactory_system1.06872986
56MP0004147_increased_porphyrin_level1.06630885
57MP0003890_abnormal_embryonic-extraembry1.06150300
58MP0009697_abnormal_copulation1.05878217
59MP0001119_abnormal_female_reproductive1.05578500
60MP0006054_spinal_hemorrhage1.05433078
61MP0000703_abnormal_thymus_morphology1.02899745
62MP0004197_abnormal_fetal_growth/weight/1.01915405
63MP0002132_abnormal_respiratory_system1.01794405
64MP0002398_abnormal_bone_marrow0.97462433
65MP0002233_abnormal_nose_morphology0.96732140
66MP0001293_anophthalmia0.96003114
67MP0006036_abnormal_mitochondrial_physio0.95278142
68MP0002722_abnormal_immune_system0.93917811
69MP0000358_abnormal_cell_content/0.92335709
70MP0005084_abnormal_gallbladder_morpholo0.91883885
71MP0000689_abnormal_spleen_morphology0.91156697
72MP0000647_abnormal_sebaceous_gland0.91116710
73MP0002234_abnormal_pharynx_morphology0.89924401
74MP0002160_abnormal_reproductive_system0.88430193
75MP0005389_reproductive_system_phenotype0.87290873
76MP0004133_heterotaxia0.84288051
77MP0003941_abnormal_skin_development0.82588998
78MP0009379_abnormal_foot_pigmentation0.82513257
79MP0000858_altered_metastatic_potential0.81227866
80MP0001853_heart_inflammation0.80798020
81MP0002429_abnormal_blood_cell0.77152635
82MP0002102_abnormal_ear_morphology0.75922700
83MP0006035_abnormal_mitochondrial_morpho0.75865129
84MP0005384_cellular_phenotype0.75493205
85MP0002111_abnormal_tail_morphology0.73204980
86MP0005253_abnormal_eye_physiology0.72112321
87MP0001919_abnormal_reproductive_system0.69011794
88MP0009053_abnormal_anal_canal0.68714440
89MP0000537_abnormal_urethra_morphology0.68165283
90MP0005023_abnormal_wound_healing0.67785908
91MP0005621_abnormal_cell_physiology0.67220865
92MP0000631_abnormal_neuroendocrine_gland0.66977683
93MP0002697_abnormal_eye_size0.66236860
94MP0001881_abnormal_mammary_gland0.65972352
95MP0005266_abnormal_metabolism0.65712951
96MP0003755_abnormal_palate_morphology0.65308560
97MP0005395_other_phenotype0.64019543
98MP0000049_abnormal_middle_ear0.63984767
99MP0003699_abnormal_female_reproductive0.63359413
100MP0003221_abnormal_cardiomyocyte_apopto0.62368393
101MP0003937_abnormal_limbs/digits/tail_de0.61616653
102MP0000716_abnormal_immune_system0.61109497
103MP0005391_vision/eye_phenotype0.60924196
104MP0004215_abnormal_myocardial_fiber0.60811808
105MP0000427_abnormal_hair_cycle0.60542904
106MP0009703_decreased_birth_body0.59392108
107MP0009672_abnormal_birth_weight0.58912383
108MP0002653_abnormal_ependyma_morphology0.58657382
109MP0001346_abnormal_lacrimal_gland0.58463725
110MP0001727_abnormal_embryo_implantation0.58145740
111MP0002163_abnormal_gland_morphology0.57542798
112MP0008872_abnormal_physiological_respon0.57079555
113MP0002837_dystrophic_cardiac_calcinosis0.56763513
114MP0002938_white_spotting0.56677180
115MP0002161_abnormal_fertility/fecundity0.56295288
116MP0002095_abnormal_skin_pigmentation0.56028192
117MP0001485_abnormal_pinna_reflex0.56020974
118MP0002751_abnormal_autonomic_nervous0.55942833
119MP0005075_abnormal_melanosome_morpholog0.55522699
120MP0005187_abnormal_penis_morphology0.55322036
121MP0001915_intracranial_hemorrhage0.55169555
122MP0001764_abnormal_homeostasis0.54529566
123MP0000477_abnormal_intestine_morphology0.54323959
124MP0005410_abnormal_fertilization0.54316591
125MP0003698_abnormal_male_reproductive0.54042833
126MP0003119_abnormal_digestive_system0.53978384
127MP0004264_abnormal_extraembryonic_tissu0.53318061
128MP0001286_abnormal_eye_development0.53311791
129MP0005076_abnormal_cell_differentiation0.53012110
130MP0005408_hypopigmentation0.48804047
131MP0002075_abnormal_coat/hair_pigmentati0.41891131
132MP0001186_pigmentation_phenotype0.41081626
133MP0003936_abnormal_reproductive_system0.39953490

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.52395997
2Breast hypoplasia (HP:0003187)4.54071290
3Reticulocytopenia (HP:0001896)4.34469358
4Chromsome breakage (HP:0040012)4.15533696
5Abnormality of cells of the erythroid lineage (HP:0012130)4.12913665
6Oral leukoplakia (HP:0002745)4.09363716
7Abnormal number of erythroid precursors (HP:0012131)3.94102481
8Acute necrotizing encephalopathy (HP:0006965)3.84654369
9Aplastic anemia (HP:0001915)3.79753503
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.78966576
11Colon cancer (HP:0003003)3.73829894
12Increased hepatocellular lipid droplets (HP:0006565)3.62522099
13Acute encephalopathy (HP:0006846)3.60448231
14Patellar aplasia (HP:0006443)3.49108713
15Abnormal mitochondria in muscle tissue (HP:0008316)3.43400180
16Degeneration of anterior horn cells (HP:0002398)3.42021385
17Abnormality of the anterior horn cell (HP:0006802)3.42021385
18Abnormality of the preputium (HP:0100587)3.40772709
19Abnormality of chromosome stability (HP:0003220)3.38623309
20Lipid accumulation in hepatocytes (HP:0006561)3.38491771
21Mitochondrial inheritance (HP:0001427)3.32212101
22Meckel diverticulum (HP:0002245)3.31472279
23Carpal bone hypoplasia (HP:0001498)3.30120786
24Increased CSF lactate (HP:0002490)3.27056640
25Aplasia/Hypoplasia of the patella (HP:0006498)3.25834877
26Rough bone trabeculation (HP:0100670)3.22200229
27Abnormality of the ileum (HP:0001549)3.14525611
28Selective tooth agenesis (HP:0001592)3.13192474
29Progressive macrocephaly (HP:0004481)3.10754888
30Medulloblastoma (HP:0002885)3.05524506
31Cerebral hypomyelination (HP:0006808)2.97782301
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.96498121
33Myelodysplasia (HP:0002863)2.91827329
34Small intestinal stenosis (HP:0012848)2.89149997
35Duodenal stenosis (HP:0100867)2.89149997
36Absent thumb (HP:0009777)2.86735845
37Macrocytic anemia (HP:0001972)2.86639033
38Hepatocellular necrosis (HP:0001404)2.77736182
39Cerebral edema (HP:0002181)2.74141890
40Microretrognathia (HP:0000308)2.73649995
4111 pairs of ribs (HP:0000878)2.72342940
42Bone marrow hypocellularity (HP:0005528)2.70253136
43Impulsivity (HP:0100710)2.68121251
44Abnormal lung lobation (HP:0002101)2.67853663
45Absent radius (HP:0003974)2.66637168
46Renal Fanconi syndrome (HP:0001994)2.66035501
47Premature graying of hair (HP:0002216)2.65599957
48Hepatic necrosis (HP:0002605)2.65379315
49Agnosia (HP:0010524)2.62954461
50Pallor (HP:0000980)2.62457453
51Abnormality of methionine metabolism (HP:0010901)2.56998878
52Sloping forehead (HP:0000340)2.56022992
53Abnormality of the labia minora (HP:0012880)2.49864603
54Aplasia involving forearm bones (HP:0009822)2.47201395
55Absent forearm bone (HP:0003953)2.47201395
56Neoplasm of the pancreas (HP:0002894)2.46524623
57Duplicated collecting system (HP:0000081)2.39636420
58Premature ovarian failure (HP:0008209)2.38278797
59Abnormality of the duodenum (HP:0002246)2.37695210
60Abnormal trabecular bone morphology (HP:0100671)2.36239937
61Cellular immunodeficiency (HP:0005374)2.36031586
62Increased serum pyruvate (HP:0003542)2.35848838
63Ependymoma (HP:0002888)2.35582564
64Secondary amenorrhea (HP:0000869)2.35537382
65Supernumerary spleens (HP:0009799)2.35178488
66Rhabdomyosarcoma (HP:0002859)2.34373962
67Horseshoe kidney (HP:0000085)2.31017976
68Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.29135020
69Methylmalonic acidemia (HP:0002912)2.28714361
70Multiple enchondromatosis (HP:0005701)2.26317301
71Abnormality of glycolysis (HP:0004366)2.25795979
72Lactic acidosis (HP:0003128)2.25098112
73Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24976763
74Pancytopenia (HP:0001876)2.24773291
75Trismus (HP:0000211)2.24760499
76Type I transferrin isoform profile (HP:0003642)2.22985359
77Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22825219
78Abnormality of the renal collecting system (HP:0004742)2.20291904
79Triphalangeal thumb (HP:0001199)2.20222949
80Microvesicular hepatic steatosis (HP:0001414)2.17418631
81Thrombocytosis (HP:0001894)2.17367828
82Tracheoesophageal fistula (HP:0002575)2.15403042
83Cleft eyelid (HP:0000625)2.13363777
84Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13233568
85Abnormal number of incisors (HP:0011064)2.13181755
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11761977
87Abnormal protein N-linked glycosylation (HP:0012347)2.11761977
88Abnormal protein glycosylation (HP:0012346)2.11761977
89Abnormal glycosylation (HP:0012345)2.11761977
90Neoplasm of the colon (HP:0100273)2.11361642
91Abnormality of the pons (HP:0007361)2.09935421
92Hypoplasia of the capital femoral epiphysis (HP:0003090)2.09666150
93Median cleft lip (HP:0000161)2.07698114
94Nephroblastoma (Wilms tumor) (HP:0002667)2.07416198
95Hypoplasia of the pons (HP:0012110)2.06757939
96Atresia of the external auditory canal (HP:0000413)2.05144343
97Ectopic kidney (HP:0000086)2.05129846
98Increased intramyocellular lipid droplets (HP:0012240)2.04719602
99Abnormality of pyrimidine metabolism (HP:0004353)2.03948407
100Exercise intolerance (HP:0003546)2.03847818
1013-Methylglutaconic aciduria (HP:0003535)2.02934618
102Abnormality of serum amino acid levels (HP:0003112)2.02332550
103Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01569303
104Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01569303
105Respiratory difficulties (HP:0002880)2.01132347
106Exertional dyspnea (HP:0002875)1.98325787
107Short thumb (HP:0009778)1.97372868
108Squamous cell carcinoma (HP:0002860)1.96181164
109Increased serum lactate (HP:0002151)1.95930815
110Pancreatic fibrosis (HP:0100732)1.95770555
111Hypoplastic pelvis (HP:0008839)1.95629281
112Abnormal spermatogenesis (HP:0008669)1.94452186
113Respiratory failure (HP:0002878)1.94337308
114Clubbing of toes (HP:0100760)1.94215986
115Embryonal renal neoplasm (HP:0011794)1.93841920
116Leukodystrophy (HP:0002415)1.92652310
117Reduced antithrombin III activity (HP:0001976)1.92545919
118Pancreatic cysts (HP:0001737)1.91661911
119Absent septum pellucidum (HP:0001331)1.90912867
120Megaloblastic anemia (HP:0001889)1.90024728
121Lymphoma (HP:0002665)1.89882973
122CNS hypomyelination (HP:0003429)1.88508207
123Basal cell carcinoma (HP:0002671)1.87803545
124Abnormality of the carotid arteries (HP:0005344)1.86721314
125Septo-optic dysplasia (HP:0100842)1.84430717
126Volvulus (HP:0002580)1.83671825
127Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83514246
128Abnormality of alanine metabolism (HP:0010916)1.83514246
129Hyperalaninemia (HP:0003348)1.83514246
130Abnormality of the septum pellucidum (HP:0007375)1.82928709
131Hyperglycinemia (HP:0002154)1.82235077
132Methylmalonic aciduria (HP:0012120)1.80450471
133Slender long bone (HP:0003100)1.80264714
134Amaurosis fugax (HP:0100576)1.79668292
135Ureteral duplication (HP:0000073)1.78993629
136Atrophy/Degeneration involving motor neurons (HP:0007373)1.78619944
137Molar tooth sign on MRI (HP:0002419)1.78247120
138Abnormality of midbrain morphology (HP:0002418)1.78247120
139Pancreatic islet-cell hyperplasia (HP:0004510)1.77805301
140Lethargy (HP:0001254)1.77438754
141Irregular epiphyses (HP:0010582)1.77432509
142Hypoplasia of the radius (HP:0002984)1.77146531
143Cafe-au-lait spot (HP:0000957)1.77051231
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.77001238
145Sparse eyelashes (HP:0000653)1.76365278
146Amniotic constriction ring (HP:0009775)1.75693053
147Pulmonary fibrosis (HP:0002206)1.75381115
148Optic nerve coloboma (HP:0000588)1.71452561
149Missing ribs (HP:0000921)1.70778616
150Increased nuchal translucency (HP:0010880)1.70393622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.38369330
2WEE14.66555493
3CDC74.02221309
4VRK23.39273222
5EIF2AK13.35891181
6NEK22.71135254
7TTK2.64357553
8STK162.56863507
9PLK42.55812812
10SRPK12.54020750
11NEK12.48889539
12BRSK22.43881162
13EIF2AK32.28575168
14PLK12.24470801
15ACVR1B2.20069872
16TSSK62.16772162
17VRK12.16627909
18NME22.12247167
19BMPR1B1.96564876
20AURKB1.84204486
21PLK31.79317975
22MKNK11.73377010
23CCNB11.68892141
24TAF11.66748679
25CDK71.66669310
26ATR1.65227943
27TESK21.63592873
28BRSK11.62005460
29PASK1.61733430
30TRIM281.51438336
31RPS6KB21.49951771
32TLK11.45774561
33CHEK21.40930588
34RPS6KA41.39058025
35AURKA1.37979836
36DYRK31.37636910
37MAP3K81.33216444
38STK101.24088151
39MKNK21.22205097
40TGFBR11.14789645
41CHEK11.11055897
42PBK1.10356250
43ZAK1.08063065
44WNK31.07909530
45CDK81.03956714
46STK41.00231869
47CDK40.99691414
48BRAF0.95931251
49MAP4K20.95795308
50EIF2AK20.93580060
51PAK40.90462649
52MAP3K120.90455058
53TNIK0.87484804
54EPHA20.83563481
55ATM0.83063330
56MELK0.82138652
57SCYL20.81517814
58PIM20.73308170
59CDK20.71131468
60CSNK2A10.71101679
61STK38L0.69748442
62PAK10.68322233
63PIM10.67976978
64TESK10.66833356
65CSNK2A20.66134298
66EEF2K0.61386020
67PLK20.59563937
68CDK10.59241035
69KDR0.59173128
70PDK30.58499969
71PDK40.58499969
72FLT30.58494602
73PRKCI0.57981040
74MST40.55978625
75CDK90.54623716
76ERBB30.52215065
77NME10.51460604
78OXSR10.49874096
79LRRK20.49510157
80TEC0.49062739
81CSNK1G10.48645262
82ERBB40.46737565
83DAPK10.45865257
84STK30.45390694
85MAPKAPK30.45044674
86CDK60.44836151
87STK390.44610351
88BCR0.42982404
89MAPKAPK50.42214994
90CDK30.41377963
91CDK120.41247958
92ALK0.40994523
93MAP3K110.40056105
94BCKDK0.39911034
95RPS6KA50.39053719
96PNCK0.38347104
97STK240.38339575
98GRK10.38314294
99FRK0.38170322
100CDK190.37936828
101ABL20.35459421
102MAP4K10.33813310
103BTK0.33535105
104DYRK20.33465772
105MAP2K30.33126351
106INSRR0.33021749
107CLK10.32057813
108MARK30.30694677
109TAOK30.30499591
110PDK20.29073261
111LATS10.28314152
112ILK0.27207804
113RAF10.27055289
114TAOK20.26418179
115MUSK0.26199598
116LATS20.26059141
117WNK40.24369185
118FGFR10.24159183
119MST1R0.24129309
120IRAK40.23325525
121PRKDC0.22769591
122PINK10.22194210
123CSNK1A10.21813880
124AKT20.20539469
125MOS0.19391662
126MAP3K30.19002712
127CSNK1E0.18945559
128NEK90.18740696
129NUAK10.18291945
130CSNK1G30.17240162
131LIMK10.15456051
132BRD40.14974611
133MAPKAPK20.14262516

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.11106356
2Mismatch repair_Homo sapiens_hsa034304.42286133
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.66594839
4Proteasome_Homo sapiens_hsa030503.58780634
5Ribosome_Homo sapiens_hsa030103.56264524
6RNA polymerase_Homo sapiens_hsa030203.39955188
7Spliceosome_Homo sapiens_hsa030403.21006524
8Base excision repair_Homo sapiens_hsa034103.19701743
9Homologous recombination_Homo sapiens_hsa034403.17527623
10* RNA transport_Homo sapiens_hsa030133.04047027
11Nucleotide excision repair_Homo sapiens_hsa034203.01836135
12Cell cycle_Homo sapiens_hsa041102.84209484
13Pyrimidine metabolism_Homo sapiens_hsa002402.65234826
14One carbon pool by folate_Homo sapiens_hsa006702.52859510
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.37637313
16Fanconi anemia pathway_Homo sapiens_hsa034602.33483752
17Non-homologous end-joining_Homo sapiens_hsa034502.32679734
18RNA degradation_Homo sapiens_hsa030182.14087483
19Basal transcription factors_Homo sapiens_hsa030222.13162500
20p53 signaling pathway_Homo sapiens_hsa041151.57316626
21Propanoate metabolism_Homo sapiens_hsa006401.55442731
22mRNA surveillance pathway_Homo sapiens_hsa030151.51003834
23Purine metabolism_Homo sapiens_hsa002301.47010637
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25238690
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16135851
26Epstein-Barr virus infection_Homo sapiens_hsa051691.12175681
27Fatty acid elongation_Homo sapiens_hsa000621.08462789
28Protein export_Homo sapiens_hsa030601.08246423
29Systemic lupus erythematosus_Homo sapiens_hsa053221.07743272
30Oocyte meiosis_Homo sapiens_hsa041141.06685364
31Folate biosynthesis_Homo sapiens_hsa007901.03776806
32Steroid biosynthesis_Homo sapiens_hsa001001.03119163
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01689034
34Cysteine and methionine metabolism_Homo sapiens_hsa002700.95767190
35Vitamin B6 metabolism_Homo sapiens_hsa007500.90396034
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89710221
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87235917
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87222484
39Drug metabolism - other enzymes_Homo sapiens_hsa009830.85940700
40Biosynthesis of amino acids_Homo sapiens_hsa012300.83380070
41Pentose phosphate pathway_Homo sapiens_hsa000300.82180161
42Herpes simplex infection_Homo sapiens_hsa051680.79087763
43Viral carcinogenesis_Homo sapiens_hsa052030.77781421
44Huntingtons disease_Homo sapiens_hsa050160.76851860
45Antigen processing and presentation_Homo sapiens_hsa046120.76771471
46Selenocompound metabolism_Homo sapiens_hsa004500.76223243
47Glutathione metabolism_Homo sapiens_hsa004800.64526198
48Parkinsons disease_Homo sapiens_hsa050120.64126196
49Butanoate metabolism_Homo sapiens_hsa006500.62286432
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60664097
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.58725664
52HTLV-I infection_Homo sapiens_hsa051660.58350815
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58038986
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55573629
55Cardiac muscle contraction_Homo sapiens_hsa042600.55200689
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54986032
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53807526
58Carbon metabolism_Homo sapiens_hsa012000.51778057
59Legionellosis_Homo sapiens_hsa051340.51732018
60Sulfur metabolism_Homo sapiens_hsa009200.50292210
61Sulfur relay system_Homo sapiens_hsa041220.48042669
62Peroxisome_Homo sapiens_hsa041460.46872920
63Thyroid cancer_Homo sapiens_hsa052160.46761568
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45557117
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45356474
66Oxidative phosphorylation_Homo sapiens_hsa001900.45200919
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42773850
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41218578
69N-Glycan biosynthesis_Homo sapiens_hsa005100.39181307
70Primary immunodeficiency_Homo sapiens_hsa053400.38235392
71Nitrogen metabolism_Homo sapiens_hsa009100.37743654
72Caffeine metabolism_Homo sapiens_hsa002320.37574707
73Small cell lung cancer_Homo sapiens_hsa052220.36611430
74Galactose metabolism_Homo sapiens_hsa000520.36561555
75Fructose and mannose metabolism_Homo sapiens_hsa000510.35171407
76Fatty acid metabolism_Homo sapiens_hsa012120.34924268
77MicroRNAs in cancer_Homo sapiens_hsa052060.32736349
78Metabolic pathways_Homo sapiens_hsa011000.32133907
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31005987
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30796428
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30745659
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30599125
83Phototransduction_Homo sapiens_hsa047440.29816329
84Apoptosis_Homo sapiens_hsa042100.29521494
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29355696
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.29200806
87Vitamin digestion and absorption_Homo sapiens_hsa049770.28929669
88TGF-beta signaling pathway_Homo sapiens_hsa043500.28905960
89beta-Alanine metabolism_Homo sapiens_hsa004100.28628537
90Alcoholism_Homo sapiens_hsa050340.28251050
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27012930
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26877722
93Hedgehog signaling pathway_Homo sapiens_hsa043400.26804741
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26191986
95Fatty acid degradation_Homo sapiens_hsa000710.26182660
96Tryptophan metabolism_Homo sapiens_hsa003800.24307187
97Arachidonic acid metabolism_Homo sapiens_hsa005900.22342223
98Regulation of autophagy_Homo sapiens_hsa041400.21775567
99Measles_Homo sapiens_hsa051620.21652230
100Olfactory transduction_Homo sapiens_hsa047400.20681525
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20490285
102Colorectal cancer_Homo sapiens_hsa052100.17811444
103Shigellosis_Homo sapiens_hsa051310.17680562
104Hepatitis B_Homo sapiens_hsa051610.17615199
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16342412
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16154093
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16108031
108Wnt signaling pathway_Homo sapiens_hsa043100.15975907
109Retinol metabolism_Homo sapiens_hsa008300.15556257
110Hippo signaling pathway_Homo sapiens_hsa043900.15215495
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.14747116
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14666101
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.14332483
114Hematopoietic cell lineage_Homo sapiens_hsa046400.13569001
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13389639
116HIF-1 signaling pathway_Homo sapiens_hsa040660.13380005
117Chemical carcinogenesis_Homo sapiens_hsa052040.13373321
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.12257830
119Influenza A_Homo sapiens_hsa051640.11602495
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11162296
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.09499060
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.09470708
123Basal cell carcinoma_Homo sapiens_hsa052170.08396713
124Pyruvate metabolism_Homo sapiens_hsa006200.08275715
125Alzheimers disease_Homo sapiens_hsa050100.07644376
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07316128
127Renin-angiotensin system_Homo sapiens_hsa046140.07308436
128Arginine and proline metabolism_Homo sapiens_hsa003300.07303416
129Notch signaling pathway_Homo sapiens_hsa043300.06743666
130Pathways in cancer_Homo sapiens_hsa052000.06660643
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.06530269
132Linoleic acid metabolism_Homo sapiens_hsa005910.05221678
133Asthma_Homo sapiens_hsa053100.05003807
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.03350295

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