NUP50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)4.91074551
2nuclear pore complex assembly (GO:0051292)4.88889305
3nuclear pore organization (GO:0006999)4.82885677
4DNA unwinding involved in DNA replication (GO:0006268)4.75945588
5folic acid-containing compound biosynthetic process (GO:0009396)4.46754071
6* mitotic nuclear envelope disassembly (GO:0007077)4.33530372
7protein localization to chromosome, centromeric region (GO:0071459)4.32154749
8regulation of DNA endoreduplication (GO:0032875)4.10321878
9* nuclear envelope disassembly (GO:0051081)4.04322310
10* membrane disassembly (GO:0030397)4.04322310
11DNA topological change (GO:0006265)4.03846809
12pre-miRNA processing (GO:0031054)3.96021865
13mitotic sister chromatid segregation (GO:0000070)3.89279739
14mitotic metaphase plate congression (GO:0007080)3.85845469
15mitotic chromosome condensation (GO:0007076)3.85840277
16mitotic sister chromatid cohesion (GO:0007064)3.84604073
17DNA replication initiation (GO:0006270)3.84560472
18sister chromatid segregation (GO:0000819)3.81547442
19DNA strand elongation involved in DNA replication (GO:0006271)3.76706861
20formation of translation preinitiation complex (GO:0001731)3.75563437
21DNA replication-dependent nucleosome assembly (GO:0006335)3.72714813
22DNA replication-dependent nucleosome organization (GO:0034723)3.72714813
23heterochromatin organization (GO:0070828)3.70551317
24DNA replication checkpoint (GO:0000076)3.68687285
25mitotic G2/M transition checkpoint (GO:0044818)3.65840054
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.65417003
27DNA ligation (GO:0006266)3.63964369
28DNA duplex unwinding (GO:0032508)3.63841938
29regulation of spindle organization (GO:0090224)3.62525680
30regulation of RNA export from nucleus (GO:0046831)3.62463796
31DNA geometric change (GO:0032392)3.62446554
32DNA double-strand break processing (GO:0000729)3.60567718
33DNA strand elongation (GO:0022616)3.60152078
34non-recombinational repair (GO:0000726)3.58375156
35double-strand break repair via nonhomologous end joining (GO:0006303)3.58375156
36IMP biosynthetic process (GO:0006188)3.55571722
37pore complex assembly (GO:0046931)3.55058928
38positive regulation of chromosome segregation (GO:0051984)3.54854636
39regulation of histone H3-K9 methylation (GO:0051570)3.54204858
40negative regulation of DNA-dependent DNA replication (GO:2000104)3.48143068
41nucleobase biosynthetic process (GO:0046112)3.47762906
42regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.45110027
43negative regulation of histone methylation (GO:0031061)3.41265886
44regulation of translational fidelity (GO:0006450)3.40336891
45V(D)J recombination (GO:0033151)3.38474326
46kinetochore assembly (GO:0051382)3.37001861
47metaphase plate congression (GO:0051310)3.37000468
48regulation of mitotic sister chromatid separation (GO:0010965)3.36327858
49regulation of mitotic sister chromatid segregation (GO:0033047)3.36327858
50regulation of sister chromatid segregation (GO:0033045)3.36327858
51regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.26389227
52ribosome assembly (GO:0042255)3.24081308
53mitotic G2 DNA damage checkpoint (GO:0007095)3.21908814
54* nuclear envelope organization (GO:0006998)3.20305351
55protein localization to chromosome (GO:0034502)3.19655931
56regulation of translational termination (GO:0006449)3.19599435
57regulation of mitotic spindle organization (GO:0060236)3.19061395
58negative regulation of mRNA metabolic process (GO:1903312)3.18406763
59positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.18273528
60positive regulation of mitotic sister chromatid separation (GO:1901970)3.18273528
61positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.18273528
62purine nucleobase biosynthetic process (GO:0009113)3.17763922
63chromatin assembly (GO:0031497)3.16842910
64replication fork processing (GO:0031297)3.16526351
65negative regulation of mRNA processing (GO:0050686)3.15848628
66chromatin assembly or disassembly (GO:0006333)3.14706667
67dosage compensation (GO:0007549)3.14484019
68sister chromatid cohesion (GO:0007062)3.14356423
69regulation of sister chromatid cohesion (GO:0007063)3.13474091
70IMP metabolic process (GO:0046040)3.12944562
71establishment of chromosome localization (GO:0051303)3.12334383
72translesion synthesis (GO:0019985)3.11824805
73telomere maintenance via semi-conservative replication (GO:0032201)3.11419463
74negative regulation of DNA repair (GO:0045738)3.09145918
75regulation of centrosome duplication (GO:0010824)3.08165811
76regulation of chromosome segregation (GO:0051983)3.07194590
77DNA conformation change (GO:0071103)3.04910389
78establishment of integrated proviral latency (GO:0075713)3.03386644
79regulation of gene silencing by RNA (GO:0060966)3.02462980
80regulation of posttranscriptional gene silencing (GO:0060147)3.02462980
81regulation of gene silencing by miRNA (GO:0060964)3.02462980
82kinetochore organization (GO:0051383)3.01924652
83somatic cell DNA recombination (GO:0016444)3.00823586
84somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.00823586
85chromosome condensation (GO:0030261)2.98716552
86regulation of centrosome cycle (GO:0046605)2.98131679
87DNA replication-independent nucleosome organization (GO:0034724)2.98108767
88DNA replication-independent nucleosome assembly (GO:0006336)2.98108767
89chromatin remodeling at centromere (GO:0031055)2.97427916
90mRNA stabilization (GO:0048255)2.94559988
91RNA stabilization (GO:0043489)2.94559988
92glucocorticoid receptor signaling pathway (GO:0042921)2.93594840
93histone H2A monoubiquitination (GO:0035518)2.92526034
94attachment of spindle microtubules to kinetochore (GO:0008608)2.90417360
95CENP-A containing nucleosome assembly (GO:0034080)2.90029363
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89757920
97regulation of mitotic spindle checkpoint (GO:1903504)2.88932460
98regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.88932460
99ATP-dependent chromatin remodeling (GO:0043044)2.87869125
100histone mRNA catabolic process (GO:0071044)2.87215448
101mitotic recombination (GO:0006312)2.87118017
102maturation of SSU-rRNA (GO:0030490)2.86628378
103meiotic chromosome segregation (GO:0045132)2.86471785
104negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.85856555
105telomere maintenance via recombination (GO:0000722)2.85434014
106negative regulation of chromosome segregation (GO:0051985)2.84234255
107spindle checkpoint (GO:0031577)2.84052859
108telomere maintenance (GO:0000723)2.83707829
109somatic diversification of immune receptors via somatic mutation (GO:0002566)2.82033064
110somatic hypermutation of immunoglobulin genes (GO:0016446)2.82033064
111regulation of centriole replication (GO:0046599)2.82018603
112regulation of nucleobase-containing compound transport (GO:0032239)2.81971481
113regulation of helicase activity (GO:0051095)2.81403775
114histone-serine phosphorylation (GO:0035404)2.81132434
115regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80960116
116chromosome segregation (GO:0007059)2.80040641
117ribosome biogenesis (GO:0042254)2.76970213
118negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76273225
119negative regulation of sister chromatid segregation (GO:0033046)2.76273225
120negative regulation of mitotic sister chromatid separation (GO:2000816)2.76273225
121negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76273225
122monoubiquitinated protein deubiquitination (GO:0035520)2.76173956
123spindle assembly checkpoint (GO:0071173)2.75940653
1243-UTR-mediated mRNA stabilization (GO:0070935)2.75818458
125regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.75164299
126histone exchange (GO:0043486)2.74913039
127mitotic spindle checkpoint (GO:0071174)2.72176170
128mitotic spindle assembly checkpoint (GO:0007094)2.70766953
129negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.68910604
130DNA packaging (GO:0006323)2.68374438
131negative regulation of RNA splicing (GO:0033119)2.68296712
132DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.66563104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.44655632
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.97651199
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.58634510
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.57537301
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26778670
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.20747722
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.10080519
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61424032
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.60548068
10MYC_22102868_ChIP-Seq_BL_Human2.53193678
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38399984
12AR_21909140_ChIP-Seq_LNCAP_Human2.31739852
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.30897075
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11998769
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09279765
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.05423562
17* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03578677
18XRN2_22483619_ChIP-Seq_HELA_Human1.98247832
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91723673
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.86321657
21* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82625763
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.82198210
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77345704
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.74586622
25CIITA_25753668_ChIP-Seq_RAJI_Human1.67689612
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67436714
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60277756
28KDM5A_27292631_Chip-Seq_BREAST_Human1.55994027
29VDR_23849224_ChIP-Seq_CD4+_Human1.55081041
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54299429
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53921717
32* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51456838
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.51101544
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49217759
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47566758
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.47054264
37VDR_21846776_ChIP-Seq_THP-1_Human1.45476531
38* GABP_19822575_ChIP-Seq_HepG2_Human1.45443515
39FOXP3_21729870_ChIP-Seq_TREG_Human1.44879186
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42785790
41TTF2_22483619_ChIP-Seq_HELA_Human1.42514137
42* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42496240
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42221539
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.41120735
45DCP1A_22483619_ChIP-Seq_HELA_Human1.39738524
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39342898
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39160854
48* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38907736
49* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36189739
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35087963
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34584766
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34329621
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33698881
54TFEB_21752829_ChIP-Seq_HELA_Human1.31644092
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31063002
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29009210
57SPI1_23547873_ChIP-Seq_NB4_Human1.28174108
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25323275
59* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24031226
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23926434
61* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23769204
62* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22304182
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21415642
64EWS_26573619_Chip-Seq_HEK293_Human1.20328410
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17501016
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17389503
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.16620478
68ELK1_19687146_ChIP-ChIP_HELA_Human1.12810401
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10901655
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09946311
71STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08801050
72NANOG_21062744_ChIP-ChIP_HESCs_Human1.08084999
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06678789
74MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06235360
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04927840
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04500548
77UTX_26944678_Chip-Seq_JUKART_Human1.02852074
78* TCF7_22412390_ChIP-Seq_EML_Mouse1.02358052
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01780617
80* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00627849
81* CHD1_26751641_Chip-Seq_LNCaP_Human1.00456832
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00105250
83* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96929357
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96133016
85* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95981007
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95738193
87ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95524121
88TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95167797
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94989958
90MYB_26560356_Chip-Seq_TH1_Human0.93451222
91* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93255771
92SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93184622
93MAF_26560356_Chip-Seq_TH1_Human0.92713386
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92441860
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91880521
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91858646
97SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91276108
98ATF3_27146783_Chip-Seq_COLON_Human0.90807837
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90634305
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90414960
101FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90221161
102* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90118247
103MYC_18940864_ChIP-ChIP_HL60_Human0.89707716
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89304127
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88884318
106KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88248728
107KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88248728
108KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88248728
109* MYB_26560356_Chip-Seq_TH2_Human0.87889782
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87310882
111IRF8_21731497_ChIP-ChIP_J774_Mouse0.87286639
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87207943
113* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87079580
114BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86158364
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84064595
116HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83384067
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82857777
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82716478
119* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82685484
120SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82450750
121NANOG_16153702_ChIP-ChIP_HESCs_Human0.82365392
122HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.81355772
123* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80462749
124FLI1_27457419_Chip-Seq_LIVER_Mouse0.79481332
125POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77939651
126* GATA3_26560356_Chip-Seq_TH2_Human0.74064554
127FUS_26573619_Chip-Seq_HEK293_Human0.72491099
128* GATA3_27048872_Chip-Seq_THYMUS_Human0.71027025
129IRF8_27001747_Chip-Seq_BMDM_Mouse0.70317430
130POU3F2_20337985_ChIP-ChIP_501MEL_Human0.70153061
131SOX17_20123909_ChIP-Seq_XEN_Mouse0.69333745
132FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.68399879
133NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.67730177

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.10152263
2MP0003111_abnormal_nucleus_morphology3.90163115
3MP0010094_abnormal_chromosome_stability3.75082554
4MP0004957_abnormal_blastocyst_morpholog3.56206647
5MP0008057_abnormal_DNA_replication3.43726704
6MP0003077_abnormal_cell_cycle3.40362892
7MP0010352_gastrointestinal_tract_polyps2.99786704
8MP0002009_preneoplasia2.58376299
9MP0003705_abnormal_hypodermis_morpholog2.46652828
10MP0008007_abnormal_cellular_replicative2.43401454
11MP0001730_embryonic_growth_arrest2.40882558
12MP0010307_abnormal_tumor_latency2.32928149
13MP0005076_abnormal_cell_differentiation2.31689872
14MP0008058_abnormal_DNA_repair2.29073670
15MP0000350_abnormal_cell_proliferation2.26427808
16MP0003123_paternal_imprinting2.10818509
17MP0002396_abnormal_hematopoietic_system2.00495207
18MP0002166_altered_tumor_susceptibility1.95833041
19MP0001672_abnormal_embryogenesis/_devel1.93113770
20MP0005380_embryogenesis_phenotype1.93113770
21MP0008932_abnormal_embryonic_tissue1.91885317
22MP0006054_spinal_hemorrhage1.83922012
23MP0003984_embryonic_growth_retardation1.82481826
24* MP0001697_abnormal_embryo_size1.81803443
25MP0002088_abnormal_embryonic_growth/wei1.80779387
26MP0004197_abnormal_fetal_growth/weight/1.78439176
27MP0002084_abnormal_developmental_patter1.78061749
28MP0002086_abnormal_extraembryonic_tissu1.68904350
29* MP0002085_abnormal_embryonic_tissue1.67453047
30MP0003890_abnormal_embryonic-extraembry1.67428449
31MP0008877_abnormal_DNA_methylation1.66567909
32MP0004808_abnormal_hematopoietic_stem1.63942960
33MP0002080_prenatal_lethality1.63382232
34MP0002006_tumorigenesis1.57745379
35MP0003566_abnormal_cell_adhesion1.55205015
36MP0009697_abnormal_copulation1.54173060
37MP0000490_abnormal_crypts_of1.54151739
38MP0009053_abnormal_anal_canal1.53528183
39MP0004381_abnormal_hair_follicle1.45226450
40MP0000569_abnormal_digit_pigmentation1.39252340
41MP0002019_abnormal_tumor_incidence1.35600607
42MP0010030_abnormal_orbit_morphology1.33629563
43MP0005075_abnormal_melanosome_morpholog1.31588702
44MP0001835_abnormal_antigen_presentation1.31387681
45MP0000313_abnormal_cell_death1.30574263
46MP0000537_abnormal_urethra_morphology1.29954244
47MP0002877_abnormal_melanocyte_morpholog1.29174163
48MP0009672_abnormal_birth_weight1.27068729
49MP0003121_genomic_imprinting1.24668278
50MP0005397_hematopoietic_system_phenotyp1.23591264
51MP0001545_abnormal_hematopoietic_system1.23591264
52MP0001915_intracranial_hemorrhage1.23049102
53MP0009703_decreased_birth_body1.17135891
54MP0003787_abnormal_imprinting1.16541063
55MP0001800_abnormal_humoral_immune1.16532645
56MP0000703_abnormal_thymus_morphology1.14764268
57MP0001293_anophthalmia1.14592502
58MP0009278_abnormal_bone_marrow1.13713311
59MP0005023_abnormal_wound_healing1.12671865
60MP0003567_abnormal_fetal_cardiomyocyte1.12072032
61MP0004264_abnormal_extraembryonic_tissu1.11493000
62MP0002653_abnormal_ependyma_morphology1.09613833
63MP0003786_premature_aging1.08622874
64MP0009333_abnormal_splenocyte_physiolog1.07831395
65MP0000015_abnormal_ear_pigmentation1.07435357
66MP0003119_abnormal_digestive_system1.04528755
67MP0003943_abnormal_hepatobiliary_system1.03857120
68MP0002398_abnormal_bone_marrow1.03526068
69MP0005671_abnormal_response_to1.03166679
70MP0002420_abnormal_adaptive_immunity0.99959957
71MP0001849_ear_inflammation0.99653388
72MP0003763_abnormal_thymus_physiology0.99603598
73MP0008260_abnormal_autophagy0.99218730
74MP0001819_abnormal_immune_cell0.98406467
75MP0002722_abnormal_immune_system0.97345509
76MP0002111_abnormal_tail_morphology0.95422964
77MP0000858_altered_metastatic_potential0.94902114
78MP0010234_abnormal_vibrissa_follicle0.91961309
79MP0005621_abnormal_cell_physiology0.91260882
80MP0003941_abnormal_skin_development0.90987646
81MP0000733_abnormal_muscle_development0.90971132
82MP0000689_abnormal_spleen_morphology0.90855187
83MP0006035_abnormal_mitochondrial_morpho0.90710690
84MP0002210_abnormal_sex_determination0.90625503
85MP0003300_gastrointestinal_ulcer0.90429401
86MP0002452_abnormal_antigen_presenting0.90362404
87MP0000428_abnormal_craniofacial_morphol0.89807046
88MP0001929_abnormal_gametogenesis0.89675823
89MP0003806_abnormal_nucleotide_metabolis0.88477716
90MP0001145_abnormal_male_reproductive0.88449107
91MP0000685_abnormal_immune_system0.88252863
92MP0003221_abnormal_cardiomyocyte_apopto0.86570624
93MP0005310_abnormal_salivary_gland0.85381215
94MP0005384_cellular_phenotype0.83927997
95MP0003937_abnormal_limbs/digits/tail_de0.83469043
96MP0002092_abnormal_eye_morphology0.82491499
97MP0000427_abnormal_hair_cycle0.78463309
98MP0002723_abnormal_immune_serum0.76681185
99MP0002925_abnormal_cardiovascular_devel0.76171967
100MP0000477_abnormal_intestine_morphology0.75759993
101MP0002429_abnormal_blood_cell0.74267669
102MP0000432_abnormal_head_morphology0.74197119
103MP0000653_abnormal_sex_gland0.73477314
104MP0002697_abnormal_eye_size0.72191136
105MP0000358_abnormal_cell_content/0.72182906
106MP0002254_reproductive_system_inflammat0.72045108
107MP0010678_abnormal_skin_adnexa0.71489473
108MP0002796_impaired_skin_barrier0.70764293
109MP0003115_abnormal_respiratory_system0.70311469
110MP0003935_abnormal_craniofacial_develop0.69527828
111MP0005174_abnormal_tail_pigmentation0.68738470
112MP0008770_decreased_survivor_rate0.67867240
113MP0003448_altered_tumor_morphology0.67292824
114MP0001286_abnormal_eye_development0.64750098
115MP0000716_abnormal_immune_system0.63614806
116MP0005000_abnormal_immune_tolerance0.62862849
117MP0000372_irregular_coat_pigmentation0.62849819
118MP0000598_abnormal_liver_morphology0.62635130
119MP0003718_maternal_effect0.62229335
120MP0005623_abnormal_meninges_morphology0.61762523
121MP0002405_respiratory_system_inflammati0.61120525
122MP0003315_abnormal_perineum_morphology0.60977749
123MP0003091_abnormal_cell_migration0.60901634
124MP0000377_abnormal_hair_follicle0.60118735
125MP0002095_abnormal_skin_pigmentation0.59461049
126MP0004185_abnormal_adipocyte_glucose0.59229708
127MP0000516_abnormal_urinary_system0.58928319
128MP0005367_renal/urinary_system_phenotyp0.58928319
129MP0002282_abnormal_trachea_morphology0.56238004
130MP0001119_abnormal_female_reproductive0.56099951
131MP0000371_diluted_coat_color0.55306435
132MP0000266_abnormal_heart_morphology0.54692614
133MP0003303_peritoneal_inflammation0.53840203

Predicted human phenotypes

RankGene SetZ-score
1Embryonal renal neoplasm (HP:0011794)3.80507223
2Nephroblastoma (Wilms tumor) (HP:0002667)3.78031730
3Ependymoma (HP:0002888)3.18283331
4Birth length less than 3rd percentile (HP:0003561)3.08543045
5Clubbing of toes (HP:0100760)3.02714332
6T lymphocytopenia (HP:0005403)3.02072026
7Abnormality of the anterior horn cell (HP:0006802)3.01154036
8Degeneration of anterior horn cells (HP:0002398)3.01154036
9Selective tooth agenesis (HP:0001592)2.96941688
10Medulloblastoma (HP:0002885)2.93165435
11Abnormal lung lobation (HP:0002101)2.87213613
12Rhabdomyosarcoma (HP:0002859)2.82849815
13Abnormality of T cell number (HP:0011839)2.80472478
14Colon cancer (HP:0003003)2.79375059
15Neoplasm of the adrenal cortex (HP:0100641)2.76578492
16Abnormality of the duodenum (HP:0002246)2.68874019
17Patellar aplasia (HP:0006443)2.68191385
18Deviation of the thumb (HP:0009603)2.61651460
19Short 4th metacarpal (HP:0010044)2.59192662
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.59192662
21Impulsivity (HP:0100710)2.58102201
22Chromsome breakage (HP:0040012)2.57227747
23Volvulus (HP:0002580)2.55609351
24Increased nuchal translucency (HP:0010880)2.52582674
25Overlapping toe (HP:0001845)2.49256152
26Proximal placement of thumb (HP:0009623)2.49249003
27Aplasia/Hypoplasia of the patella (HP:0006498)2.48734083
28Subacute progressive viral hepatitis (HP:0006572)2.47975954
29Acute myeloid leukemia (HP:0004808)2.47956941
30Transitional cell carcinoma of the bladder (HP:0006740)2.45663195
31Combined immunodeficiency (HP:0005387)2.40637414
32B lymphocytopenia (HP:0010976)2.39769577
33Basal cell carcinoma (HP:0002671)2.38005944
34Abnormality of the carotid arteries (HP:0005344)2.37879592
35Facial hemangioma (HP:0000329)2.37488730
36Abnormality of B cell number (HP:0010975)2.36163007
37Ectopic kidney (HP:0000086)2.34600502
38Bladder carcinoma (HP:0002862)2.33706643
39Bladder neoplasm (HP:0009725)2.33706643
40Abnormality of chromosome segregation (HP:0002916)2.32741862
41Abnormality of chromosome stability (HP:0003220)2.32376317
42Breast hypoplasia (HP:0003187)2.30816663
43Recurrent viral infections (HP:0004429)2.30628021
44Carpal bone hypoplasia (HP:0001498)2.30461007
45Abnormality of the astrocytes (HP:0100707)2.29711103
46Astrocytoma (HP:0009592)2.29711103
47Neoplasm of striated muscle (HP:0009728)2.27625777
48Prominent nose (HP:0000448)2.27471120
49Agnosia (HP:0010524)2.25896912
50Abnormality of the fingertips (HP:0001211)2.24859850
51Reticulocytopenia (HP:0001896)2.21667370
52Embryonal neoplasm (HP:0002898)2.21496442
53IgM deficiency (HP:0002850)2.19357728
54Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15508238
55Leiomyosarcoma (HP:0100243)2.14608022
56Uterine leiomyosarcoma (HP:0002891)2.14608022
57Deep philtrum (HP:0002002)2.14597133
58Myelodysplasia (HP:0002863)2.11998140
59Lymphoma (HP:0002665)2.11961308
60Biliary tract neoplasm (HP:0100574)2.11111912
61Missing ribs (HP:0000921)2.10470309
62Abnormality of the labia minora (HP:0012880)2.10370132
63High pitched voice (HP:0001620)2.08160368
64Panhypogammaglobulinemia (HP:0003139)2.07927729
65Progressive external ophthalmoplegia (HP:0000590)2.07899553
66Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.05211226
67Heterotopia (HP:0002282)2.04246914
68Atresia of the external auditory canal (HP:0000413)2.02719697
69Gastrointestinal carcinoma (HP:0002672)2.02336331
70Malignant gastrointestinal tract tumors (HP:0006749)2.02336331
71Meckel diverticulum (HP:0002245)2.02274909
72Neoplasm of the oral cavity (HP:0100649)2.02073778
73Oral leukoplakia (HP:0002745)2.01515997
74Arteriovenous malformation (HP:0100026)1.99627884
75Neoplasm of the pancreas (HP:0002894)1.99582470
76Cafe-au-lait spot (HP:0000957)1.98962734
77Long eyelashes (HP:0000527)1.98881875
78Papillary thyroid carcinoma (HP:0002895)1.97919112
79Severe combined immunodeficiency (HP:0004430)1.96773366
80Aplasia/Hypoplasia of the uvula (HP:0010293)1.94445925
81Abnormality of the ileum (HP:0001549)1.93676191
82Abnormality of T cells (HP:0002843)1.92768207
83Multiple enchondromatosis (HP:0005701)1.92336882
84Thrombocytosis (HP:0001894)1.91831918
85Cortical dysplasia (HP:0002539)1.91388700
86Hyperacusis (HP:0010780)1.89816542
87IgA deficiency (HP:0002720)1.89308060
8811 pairs of ribs (HP:0000878)1.88781086
89Glioma (HP:0009733)1.88765745
90Viral hepatitis (HP:0006562)1.88528499
91Increased density of long bones (HP:0006392)1.88379811
92Bone marrow hypocellularity (HP:0005528)1.88008282
93Broad palm (HP:0001169)1.87787359
94Metaphyseal cupping (HP:0003021)1.87301480
95Ulnar bowing (HP:0003031)1.85912136
96Amaurosis fugax (HP:0100576)1.85828462
97Absent radius (HP:0003974)1.84789564
98Recurrent bacterial skin infections (HP:0005406)1.84543013
99Broad thumb (HP:0011304)1.84328419
100Absent thumb (HP:0009777)1.83959275
101Squamous cell carcinoma (HP:0002860)1.83941162
102Cutaneous melanoma (HP:0012056)1.83463773
103Aplasia/hypoplasia of the humerus (HP:0006507)1.83234247
104Renal duplication (HP:0000075)1.82967874
105Sandal gap (HP:0001852)1.81595287
106Abnormality of the 4th metacarpal (HP:0010012)1.81465220
107Genu recurvatum (HP:0002816)1.80915555
108Abnormal delayed hypersensitivity skin test (HP:0002963)1.79996765
109Breast carcinoma (HP:0003002)1.79240740
110Hypochromic microcytic anemia (HP:0004840)1.78343537
111Prostate neoplasm (HP:0100787)1.78118161
112Rib fusion (HP:0000902)1.78043431
113Abnormal number of incisors (HP:0011064)1.77877664
114Pseudobulbar signs (HP:0002200)1.76872144
115Choanal atresia (HP:0000453)1.76804840
116Small intestinal stenosis (HP:0012848)1.76459771
117Duodenal stenosis (HP:0100867)1.76459771
118Recurrent abscess formation (HP:0002722)1.76143214
119Adenoma sebaceum (HP:0009720)1.75200205
120Angiofibromas (HP:0010615)1.75200205
121Atrophy/Degeneration involving motor neurons (HP:0007373)1.74540633
122Skin tags (HP:0010609)1.74312592
123Recurrent fungal infections (HP:0002841)1.74178050
124Neoplasm of the adrenal gland (HP:0100631)1.73301299
125Triphalangeal thumb (HP:0001199)1.73008147
126Short 5th finger (HP:0009237)1.72016588
127Trismus (HP:0000211)1.71504602
128Duplicated collecting system (HP:0000081)1.71315927
129Short humerus (HP:0005792)1.71136068
130Uterine neoplasm (HP:0010784)1.69747890
131Aplasia/Hypoplasia of the sternum (HP:0006714)1.67970843
132Aplasia involving forearm bones (HP:0009822)1.67911765
133Absent forearm bone (HP:0003953)1.67911765
134Abnormality of the preputium (HP:0100587)1.66852919
135Ovarian neoplasm (HP:0100615)1.66375322
136Abnormality of DNA repair (HP:0003254)1.65823292
137Skull defect (HP:0001362)1.65751659
138Cellular immunodeficiency (HP:0005374)1.65557320
139Short thumb (HP:0009778)1.64221155
140Neoplasm of the colon (HP:0100273)1.64198925
141Abnormality of the calcaneus (HP:0008364)1.64034484
142Pancreatic islet-cell hyperplasia (HP:0004510)1.63925327
143Rectal prolapse (HP:0002035)1.63747944
144Abnormality of cells of the lymphoid lineage (HP:0012140)1.62919487
145Hypoplasia of the capital femoral epiphysis (HP:0003090)1.61595515
146Preauricular skin tag (HP:0000384)1.61190386
147Long clavicles (HP:0000890)1.60903937
148Aqueductal stenosis (HP:0002410)1.60776286
149Cutis marmorata (HP:0000965)1.60653253
150Broad phalanges of the hand (HP:0009768)1.60320990
151Sloping forehead (HP:0000340)1.59818984
152Neoplasm of the small intestine (HP:0100833)1.59457108
153Abnormal hair whorl (HP:0010721)1.59450700
154Horseshoe kidney (HP:0000085)1.58998289
155Premature ovarian failure (HP:0008209)1.58126266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.00364865
2CDK123.26808663
3WEE13.01463386
4MAP3K102.95654716
5STK102.88130607
6EEF2K2.87624114
7NEK22.86269758
8BUB12.51321349
9TAF12.45820447
10TRIM282.44463236
11EIF2AK12.22252480
12TTK2.11362877
13MST42.06358650
14PKN21.99320687
15RPS6KB21.91913672
16SIK31.90888431
17SMG11.82511580
18LATS11.81295880
19SCYL21.80758263
20BRSK21.80138405
21MAP3K81.78473912
22SRPK11.74759798
23TRIB31.69832440
24PASK1.67612631
25NUAK11.66607733
26RPS6KA41.64480554
27STK31.61482120
28PLK11.59352758
29CDK41.55731328
30ZAK1.55366320
31DYRK31.52249568
32PLK41.52076231
33ATR1.47690366
34FLT31.45583590
35EPHA21.44546627
36CDK71.42505604
37LATS21.42216592
38YES11.41258068
39AURKB1.40138243
40TSSK61.36565795
41NEK11.34192444
42PBK1.33832181
43LRRK21.33327126
44TESK21.33058647
45ERBB31.27184211
46MKNK11.25150048
47BRD41.23595730
48CHEK21.23216416
49CHEK11.22611299
50CDK61.20405225
51PAK41.18426636
52EIF2AK21.16430911
53BMPR1B1.14188081
54PLK31.13032975
55TGFBR11.13030617
56TNIK1.12547634
57ACVR1B1.12197274
58ALK1.12003596
59TLK11.10785119
60NLK1.10504388
61STK41.09776720
62PIM11.07551453
63MAP4K11.03804786
64MTOR1.00887577
65PLK20.95644526
66MELK0.93630332
67ATM0.93463922
68MKNK20.92781716
69CDK20.89361708
70AURKA0.86352908
71TESK10.85892411
72PTK60.84056667
73BRSK10.83506868
74STK38L0.83298155
75VRK10.78741926
76ERN10.77871007
77MAP3K140.77801551
78BCR0.76361094
79GRK60.75762375
80FGR0.75096138
81FRK0.72617862
82CLK10.71978774
83RIPK40.71428235
84TEC0.70772609
85VRK20.70738178
86OXSR10.67971860
87KSR10.64327541
88WNK30.60878897
89RIPK10.60205260
90STK390.59493085
91ZAP700.58561755
92PDGFRA0.58014073
93JAK30.56941819
94CCNB10.56885813
95* CDK10.56504615
96BMX0.55760535
97IRAK40.55723308
98EIF2AK30.54878921
99CSK0.54353108
100NME20.53793245
101ICK0.53717781
102CDK90.53277170
103MAP3K50.50949881
104PAK10.50737123
105PAK20.50540536
106MAP3K30.45043159
107CAMK1D0.44186275
108MAP2K30.42222675
109CSNK2A20.42215761
110PRPF4B0.41464293
111MAP3K110.40790815
112TYK20.40398755
113FGFR30.39331459
114CSNK1E0.39272091
115TTN0.38794916
116STK240.36596066
117TXK0.36381680
118MAPKAPK30.36044046
119FGFR10.34672497
120MET0.34577502
121CSNK1D0.34024017
122MARK30.33285944
123RPS6KA10.33066363
124PRKDC0.32889494
125PDK40.32793576
126PDK30.32793576
127CHUK0.32646731
128BTK0.31948537
129MAPK140.31606966
130CSNK2A10.31164714
131DYRK1B0.30918966
132AKT20.29462899
133LYN0.29414565
134HCK0.28950062
135CSF1R0.28946019
136AKT10.28910572
137JAK10.28874562
138RAF10.28681047
139PRKCI0.28422956
140PNCK0.28248367
141CAMK1G0.26325863
142BMPR20.26148468
143ERBB40.25802998
144IRAK10.24722063

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.14976447
2Mismatch repair_Homo sapiens_hsa034303.40609772
3* RNA transport_Homo sapiens_hsa030133.20791164
4One carbon pool by folate_Homo sapiens_hsa006703.09733225
5Cell cycle_Homo sapiens_hsa041103.07299210
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.05849379
7Spliceosome_Homo sapiens_hsa030402.83617565
8Base excision repair_Homo sapiens_hsa034102.52409191
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38159334
10Homologous recombination_Homo sapiens_hsa034402.21956451
11Nucleotide excision repair_Homo sapiens_hsa034202.17528654
12mRNA surveillance pathway_Homo sapiens_hsa030151.98452155
13RNA polymerase_Homo sapiens_hsa030201.94968853
14Non-homologous end-joining_Homo sapiens_hsa034501.87468981
15p53 signaling pathway_Homo sapiens_hsa041151.78558971
16Fanconi anemia pathway_Homo sapiens_hsa034601.73127439
17RNA degradation_Homo sapiens_hsa030181.61438503
18Pyrimidine metabolism_Homo sapiens_hsa002401.60413755
19Ribosome_Homo sapiens_hsa030101.59774019
20Selenocompound metabolism_Homo sapiens_hsa004501.53399951
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45840804
22Antigen processing and presentation_Homo sapiens_hsa046121.45413142
23Viral carcinogenesis_Homo sapiens_hsa052031.45302608
24Basal transcription factors_Homo sapiens_hsa030221.42430593
25Proteasome_Homo sapiens_hsa030501.37937787
26Systemic lupus erythematosus_Homo sapiens_hsa053221.37225351
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35200486
28Epstein-Barr virus infection_Homo sapiens_hsa051691.24386417
29MicroRNAs in cancer_Homo sapiens_hsa052061.20644077
30Thyroid cancer_Homo sapiens_hsa052161.15407494
31Chronic myeloid leukemia_Homo sapiens_hsa052201.11491184
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09880361
33Herpes simplex infection_Homo sapiens_hsa051681.08923545
34Small cell lung cancer_Homo sapiens_hsa052221.08542311
35HTLV-I infection_Homo sapiens_hsa051661.08390528
36Oocyte meiosis_Homo sapiens_hsa041141.06200421
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06041162
38Biosynthesis of amino acids_Homo sapiens_hsa012301.02856065
39Pentose phosphate pathway_Homo sapiens_hsa000301.01743755
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.90080420
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85654379
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83527427
43Hippo signaling pathway_Homo sapiens_hsa043900.83372799
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81979634
45Legionellosis_Homo sapiens_hsa051340.81926401
46mTOR signaling pathway_Homo sapiens_hsa041500.81890069
47Protein export_Homo sapiens_hsa030600.81236377
48Adherens junction_Homo sapiens_hsa045200.81144212
49Lysine degradation_Homo sapiens_hsa003100.81022347
50Colorectal cancer_Homo sapiens_hsa052100.80705311
51Sulfur relay system_Homo sapiens_hsa041220.79181554
52TGF-beta signaling pathway_Homo sapiens_hsa043500.79005863
53Bladder cancer_Homo sapiens_hsa052190.78112887
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.77867405
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77289212
56Apoptosis_Homo sapiens_hsa042100.77075602
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74516120
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.72517951
59Hepatitis B_Homo sapiens_hsa051610.71622093
60Acute myeloid leukemia_Homo sapiens_hsa052210.70243400
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69195116
62Primary immunodeficiency_Homo sapiens_hsa053400.68092181
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.67895309
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.66293824
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65641115
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.63854859
67Pancreatic cancer_Homo sapiens_hsa052120.63516337
68Prostate cancer_Homo sapiens_hsa052150.63503477
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61516357
70Non-small cell lung cancer_Homo sapiens_hsa052230.61043733
71Basal cell carcinoma_Homo sapiens_hsa052170.60799991
72Inositol phosphate metabolism_Homo sapiens_hsa005620.60489437
73Notch signaling pathway_Homo sapiens_hsa043300.58874516
74Shigellosis_Homo sapiens_hsa051310.58205676
75Hematopoietic cell lineage_Homo sapiens_hsa046400.56636860
76Measles_Homo sapiens_hsa051620.56213606
77Viral myocarditis_Homo sapiens_hsa054160.56153114
78Purine metabolism_Homo sapiens_hsa002300.55024342
79Wnt signaling pathway_Homo sapiens_hsa043100.54443113
80Proteoglycans in cancer_Homo sapiens_hsa052050.52907847
81Osteoclast differentiation_Homo sapiens_hsa043800.52676314
82Vitamin B6 metabolism_Homo sapiens_hsa007500.52347205
83Renal cell carcinoma_Homo sapiens_hsa052110.51396950
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49180012
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47238386
86Carbon metabolism_Homo sapiens_hsa012000.47114781
87Endometrial cancer_Homo sapiens_hsa052130.46737157
88Folate biosynthesis_Homo sapiens_hsa007900.46243904
89B cell receptor signaling pathway_Homo sapiens_hsa046620.46053112
90Leishmaniasis_Homo sapiens_hsa051400.45945164
91HIF-1 signaling pathway_Homo sapiens_hsa040660.44533242
92Steroid biosynthesis_Homo sapiens_hsa001000.43313227
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42963623
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41420816
95N-Glycan biosynthesis_Homo sapiens_hsa005100.41026980
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39967654
97Pathways in cancer_Homo sapiens_hsa052000.39927104
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39483366
99Glioma_Homo sapiens_hsa052140.39005683
100Hepatitis C_Homo sapiens_hsa051600.38914647
101Influenza A_Homo sapiens_hsa051640.38529549
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.37975285
103Tuberculosis_Homo sapiens_hsa051520.37946767
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37222225
105Alcoholism_Homo sapiens_hsa050340.37119642
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37071575
107FoxO signaling pathway_Homo sapiens_hsa040680.36371055
108Autoimmune thyroid disease_Homo sapiens_hsa053200.35930637
109Melanoma_Homo sapiens_hsa052180.35655282
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.35037292
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33967115
112Hedgehog signaling pathway_Homo sapiens_hsa043400.32877510
113Allograft rejection_Homo sapiens_hsa053300.32157293
114Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31747417
115Toxoplasmosis_Homo sapiens_hsa051450.31352187
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29957112
117T cell receptor signaling pathway_Homo sapiens_hsa046600.29581375
118Chemokine signaling pathway_Homo sapiens_hsa040620.28579535
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28540202
120Prolactin signaling pathway_Homo sapiens_hsa049170.28137554
121Graft-versus-host disease_Homo sapiens_hsa053320.27238481
122Dorso-ventral axis formation_Homo sapiens_hsa043200.26299926
123VEGF signaling pathway_Homo sapiens_hsa043700.25042961
124AMPK signaling pathway_Homo sapiens_hsa041520.24699112
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23596380
126Glutathione metabolism_Homo sapiens_hsa004800.23267324

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