NUP62

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.21718340
2DNA strand elongation involved in DNA replication (GO:0006271)5.00896952
3DNA replication initiation (GO:0006270)4.78533618
4DNA strand elongation (GO:0022616)4.75019527
5protein localization to kinetochore (GO:0034501)4.68678458
6telomere maintenance via semi-conservative replication (GO:0032201)4.57230205
7protein localization to chromosome, centromeric region (GO:0071459)4.18745216
8* mitotic nuclear envelope disassembly (GO:0007077)4.11390178
9DNA replication-dependent nucleosome organization (GO:0034723)4.06307543
10DNA replication-dependent nucleosome assembly (GO:0006335)4.06307543
11telomere maintenance via recombination (GO:0000722)4.05231882
12folic acid-containing compound biosynthetic process (GO:0009396)4.04872861
13DNA replication checkpoint (GO:0000076)4.04193843
14formation of translation preinitiation complex (GO:0001731)3.97498616
15nuclear pore organization (GO:0006999)3.94780424
16mitotic metaphase plate congression (GO:0007080)3.89442068
17ribosomal small subunit assembly (GO:0000028)3.89426421
18maturation of SSU-rRNA (GO:0030490)3.87798921
19mitotic recombination (GO:0006312)3.86801467
20mitotic sister chromatid segregation (GO:0000070)3.83645531
21nuclear pore complex assembly (GO:0051292)3.81360644
22* membrane disassembly (GO:0030397)3.80805882
23* nuclear envelope disassembly (GO:0051081)3.80805882
24nucleobase biosynthetic process (GO:0046112)3.78745079
25IMP biosynthetic process (GO:0006188)3.75835072
26mitotic chromosome condensation (GO:0007076)3.71745118
27nucleotide-excision repair, DNA gap filling (GO:0006297)3.66552523
28telomere maintenance via telomere lengthening (GO:0010833)3.63977632
29regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.59745356
30viral transcription (GO:0019083)3.53390536
31DNA geometric change (GO:0032392)3.51145874
32DNA duplex unwinding (GO:0032508)3.50849881
33sister chromatid segregation (GO:0000819)3.50217288
34DNA topological change (GO:0006265)3.48031858
35translational termination (GO:0006415)3.47436464
36IMP metabolic process (GO:0046040)3.45399214
37metaphase plate congression (GO:0051310)3.42020014
38negative regulation of mRNA processing (GO:0050686)3.40343301
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.39656363
40DNA deamination (GO:0045006)3.38580068
41chromatin remodeling at centromere (GO:0031055)3.33479488
42regulation of spindle organization (GO:0090224)3.32516454
43attachment of spindle microtubules to kinetochore (GO:0008608)3.29895776
44purine nucleobase biosynthetic process (GO:0009113)3.29189346
45DNA replication-independent nucleosome assembly (GO:0006336)3.28767979
46DNA replication-independent nucleosome organization (GO:0034724)3.28767979
47CENP-A containing nucleosome assembly (GO:0034080)3.28550963
48translational initiation (GO:0006413)3.28359641
49ribosome biogenesis (GO:0042254)3.27624608
50translational elongation (GO:0006414)3.27529685
51kinetochore organization (GO:0051383)3.25975256
52somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25746899
53somatic hypermutation of immunoglobulin genes (GO:0016446)3.25746899
54ribosome assembly (GO:0042255)3.22694002
55establishment of viral latency (GO:0019043)3.20648299
56chromosome condensation (GO:0030261)3.19650771
57heterochromatin organization (GO:0070828)3.17912464
58negative regulation of mRNA metabolic process (GO:1903312)3.15878334
59nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.15570880
60spliceosomal tri-snRNP complex assembly (GO:0000244)3.14636545
61ribonucleoprotein complex biogenesis (GO:0022613)3.12643315
62negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.11697029
63regulation of histone H3-K9 methylation (GO:0051570)3.10344308
64positive regulation of chromosome segregation (GO:0051984)3.10261259
65establishment of chromosome localization (GO:0051303)3.10006213
66chromatin assembly or disassembly (GO:0006333)3.09722878
67translesion synthesis (GO:0019985)3.09275100
68ribosomal small subunit biogenesis (GO:0042274)3.08517421
69protein localization to chromosome (GO:0034502)3.03160113
70mitotic sister chromatid cohesion (GO:0007064)3.00935341
71negative regulation of histone methylation (GO:0031061)3.00852571
72DNA conformation change (GO:0071103)3.00837597
73ribosomal large subunit biogenesis (GO:0042273)2.99249995
74* nuclear envelope organization (GO:0006998)2.97752044
75regulation of double-strand break repair via homologous recombination (GO:0010569)2.97533537
76establishment of integrated proviral latency (GO:0075713)2.96305056
77negative regulation of RNA splicing (GO:0033119)2.95855823
78regulation of chromosome segregation (GO:0051983)2.95482050
79pseudouridine synthesis (GO:0001522)2.95197316
80histone exchange (GO:0043486)2.95040196
81kinetochore assembly (GO:0051382)2.94644377
82histone arginine methylation (GO:0034969)2.93374855
83mRNA splicing, via spliceosome (GO:0000398)2.91192193
84RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.91192193
85protein-DNA complex disassembly (GO:0032986)2.91104128
86nucleosome disassembly (GO:0006337)2.91104128
87meiotic chromosome segregation (GO:0045132)2.90070091
88rRNA processing (GO:0006364)2.90055808
89base-excision repair (GO:0006284)2.89914908
90pore complex assembly (GO:0046931)2.89639853
91rRNA transcription (GO:0009303)2.89439073
92negative regulation of chromosome segregation (GO:0051985)2.88938839
93peptidyl-arginine omega-N-methylation (GO:0035247)2.87715089
94regulation of centrosome cycle (GO:0046605)2.87383118
95regulation of translational fidelity (GO:0006450)2.86438234
96chromatin assembly (GO:0031497)2.85079594
97transcription-coupled nucleotide-excision repair (GO:0006283)2.84828420
98postreplication repair (GO:0006301)2.84571002
99RNA splicing, via transesterification reactions (GO:0000375)2.83978171
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.83797444
101regulation of gene silencing by RNA (GO:0060966)2.83621287
102regulation of posttranscriptional gene silencing (GO:0060147)2.83621287
103regulation of gene silencing by miRNA (GO:0060964)2.83621287
104DNA ligation (GO:0006266)2.83226267
105rRNA metabolic process (GO:0016072)2.81432667
106telomere maintenance (GO:0000723)2.80558623
107telomere organization (GO:0032200)2.80334383
108regulation of sister chromatid cohesion (GO:0007063)2.80088735
109negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79976593
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79976593
111negative regulation of sister chromatid segregation (GO:0033046)2.79976593
112negative regulation of mitotic sister chromatid separation (GO:2000816)2.79976593
113mismatch repair (GO:0006298)2.79383986
114spliceosomal snRNP assembly (GO:0000387)2.79144475
115SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.78582427
116chromosome segregation (GO:0007059)2.77650534
117cellular protein complex disassembly (GO:0043624)2.75881670
118ATP-dependent chromatin remodeling (GO:0043044)2.75753739
119protein complex localization (GO:0031503)2.75414076
120termination of RNA polymerase II transcription (GO:0006369)2.75007213
121DNA packaging (GO:0006323)2.72919387
122folic acid metabolic process (GO:0046655)2.72062694
123regulation of translational termination (GO:0006449)2.70057878
124regulation of mammary gland epithelial cell proliferation (GO:0033599)2.62143995
125viral mRNA export from host cell nucleus (GO:0046784)2.61162694
126transcription from mitochondrial promoter (GO:0006390)2.58975506
127DNA replication (GO:0006260)2.57592469
128regulation of mitochondrial translation (GO:0070129)2.56283203
129maturation of 5.8S rRNA (GO:0000460)2.55828641
130nucleobase-containing small molecule interconversion (GO:0015949)2.53850894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.35561230
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.42977216
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.02722985
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.67543914
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.61479216
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.20400902
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91856077
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63279128
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58112122
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.35601656
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34659850
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.33373906
13MYC_22102868_ChIP-Seq_BL_Human2.30067914
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.23838254
15* XRN2_22483619_ChIP-Seq_HELA_Human2.18196623
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16224825
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.09876142
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06425525
19AR_21909140_ChIP-Seq_LNCAP_Human2.06190916
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.04653846
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04546803
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.03382759
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.99780314
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97371427
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86557251
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81972164
27VDR_23849224_ChIP-Seq_CD4+_Human1.81301633
28* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79124862
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75308916
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71938995
31CIITA_25753668_ChIP-Seq_RAJI_Human1.68707843
32FOXP3_21729870_ChIP-Seq_TREG_Human1.67230590
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65527759
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65161643
35GABP_19822575_ChIP-Seq_HepG2_Human1.64432893
36* TTF2_22483619_ChIP-Seq_HELA_Human1.63112967
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62531946
38DCP1A_22483619_ChIP-Seq_HELA_Human1.61892955
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61027427
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59527268
41VDR_21846776_ChIP-Seq_THP-1_Human1.52519141
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.50156570
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49231533
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49214024
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45248329
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44617437
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43318008
48KDM5A_27292631_Chip-Seq_BREAST_Human1.43168422
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42288112
50* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38957868
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33899354
52* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32251993
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31128195
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29966737
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28605901
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.27270358
57LXR_22292898_ChIP-Seq_THP-1_Human1.26969376
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.26437439
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.25225408
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24971975
61* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24745719
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23069589
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22829134
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21732871
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19177952
66TFEB_21752829_ChIP-Seq_HELA_Human1.18028640
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16849429
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16665941
69ELK1_19687146_ChIP-ChIP_HELA_Human1.15300620
70* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15296234
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13306811
72MAF_26560356_Chip-Seq_TH2_Human1.12859433
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12711939
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12576451
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11597937
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11223096
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10686336
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09795085
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09671809
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08602370
81* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08391083
82PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08030021
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07404161
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07298406
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.06719262
86* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06139478
87VDR_24763502_ChIP-Seq_THP-1_Human1.04332618
88NCOR1_26117541_ChIP-Seq_K562_Human1.01515159
89ELF1_20517297_ChIP-Seq_JURKAT_Human1.01378127
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00771352
91P68_20966046_ChIP-Seq_HELA_Human1.00506312
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97518411
93SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97289175
94RACK7_27058665_Chip-Seq_MCF-7_Human0.96835406
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95313006
96SPI1_23547873_ChIP-Seq_NB4_Human0.95093767
97NANOG_21062744_ChIP-ChIP_HESCs_Human0.95056333
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94911506
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.94778491
100* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93397710
101* KDM2B_26808549_Chip-Seq_DND41_Human0.93116610
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93076746
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91828424
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90708076
105SRF_21415370_ChIP-Seq_HL-1_Mouse0.90055710
106* UTX_26944678_Chip-Seq_JUKART_Human0.87847188
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87755153
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86404815
109PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86229764
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85792272
111TCF7_22412390_ChIP-Seq_EML_Mouse0.84175291
112MAF_26560356_Chip-Seq_TH1_Human0.84066172
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79766172
114RBPJ_22232070_ChIP-Seq_NCS_Mouse0.79629481
115MYB_21317192_ChIP-Seq_ERMYB_Mouse0.79336877
116MYC_18940864_ChIP-ChIP_HL60_Human0.79226633
117KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.77714982
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77714982
119KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77714982
120NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77576865
121E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.76858076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.66483774
2MP0010094_abnormal_chromosome_stability4.46125070
3MP0003111_abnormal_nucleus_morphology4.34915311
4MP0004957_abnormal_blastocyst_morpholog4.13185818
5MP0008057_abnormal_DNA_replication3.94253963
6MP0003077_abnormal_cell_cycle3.84044338
7MP0008058_abnormal_DNA_repair2.78634125
8MP0010352_gastrointestinal_tract_polyps2.76312923
9MP0008007_abnormal_cellular_replicative2.72410418
10MP0002396_abnormal_hematopoietic_system2.54489047
11MP0005451_abnormal_body_composition2.47115723
12MP0001730_embryonic_growth_arrest2.41927976
13MP0000350_abnormal_cell_proliferation2.32535991
14MP0008932_abnormal_embryonic_tissue2.28585770
15MP0008877_abnormal_DNA_methylation2.19972817
16MP0003123_paternal_imprinting2.13506299
17MP0010307_abnormal_tumor_latency2.04532899
18MP0000490_abnormal_crypts_of1.88989596
19MP0001697_abnormal_embryo_size1.82730742
20MP0001672_abnormal_embryogenesis/_devel1.80162120
21MP0005380_embryogenesis_phenotype1.80162120
22MP0004808_abnormal_hematopoietic_stem1.73630785
23MP0005397_hematopoietic_system_phenotyp1.70442467
24MP0001545_abnormal_hematopoietic_system1.70442467
25MP0002653_abnormal_ependyma_morphology1.68342071
26MP0002085_abnormal_embryonic_tissue1.67062963
27MP0005076_abnormal_cell_differentiation1.66915053
28MP0002080_prenatal_lethality1.65622948
29MP0003984_embryonic_growth_retardation1.63395004
30MP0002084_abnormal_developmental_patter1.61108519
31MP0003786_premature_aging1.59700083
32MP0002088_abnormal_embryonic_growth/wei1.59408331
33MP0003303_peritoneal_inflammation1.59203410
34MP0002019_abnormal_tumor_incidence1.53756564
35MP0009278_abnormal_bone_marrow1.53326800
36MP0002086_abnormal_extraembryonic_tissu1.53091079
37MP0000313_abnormal_cell_death1.51321642
38MP0004197_abnormal_fetal_growth/weight/1.48454565
39MP0004185_abnormal_adipocyte_glucose1.38133157
40MP0009333_abnormal_splenocyte_physiolog1.35356902
41MP0001873_stomach_inflammation1.32988427
42MP0003567_abnormal_fetal_cardiomyocyte1.27898116
43MP0005671_abnormal_response_to1.27438246
44MP0005058_abnormal_lysosome_morphology1.26572550
45MP0000703_abnormal_thymus_morphology1.25405737
46MP0002398_abnormal_bone_marrow1.25003464
47MP0001348_abnormal_lacrimal_gland1.23576552
48MP0002210_abnormal_sex_determination1.21370125
49MP0003121_genomic_imprinting1.20132127
50MP0010030_abnormal_orbit_morphology1.19036658
51MP0002722_abnormal_immune_system1.18251601
52MP0003763_abnormal_thymus_physiology1.16984648
53MP0003436_decreased_susceptibility_to1.15962678
54MP0003890_abnormal_embryonic-extraembry1.15906595
55MP0002163_abnormal_gland_morphology1.15620092
56MP0001293_anophthalmia1.14553240
57MP0003718_maternal_effect1.11906323
58MP0000689_abnormal_spleen_morphology1.10766165
59MP0002148_abnormal_hypersensitivity_rea1.09291808
60MP0006035_abnormal_mitochondrial_morpho1.08523799
61MP0003705_abnormal_hypodermis_morpholog1.08401494
62MP0001145_abnormal_male_reproductive1.08305878
63MP0002254_reproductive_system_inflammat1.07523200
64MP0000858_altered_metastatic_potential1.06290192
65MP0001929_abnormal_gametogenesis1.06224305
66MP0005000_abnormal_immune_tolerance1.05832547
67MP0005387_immune_system_phenotype1.05121747
68MP0001790_abnormal_immune_system1.05121747
69MP0001346_abnormal_lacrimal_gland1.04575720
70MP0004233_abnormal_muscle_weight1.03883338
71MP0003566_abnormal_cell_adhesion1.02199873
72MP0001915_intracranial_hemorrhage1.01084982
73MP0005310_abnormal_salivary_gland1.00782661
74MP0001727_abnormal_embryo_implantation0.97708743
75MP0002723_abnormal_immune_serum0.95974288
76MP0005023_abnormal_wound_healing0.95920771
77MP0002429_abnormal_blood_cell0.95798061
78MP0003119_abnormal_digestive_system0.94942127
79MP0006054_spinal_hemorrhage0.93503715
80MP0000653_abnormal_sex_gland0.92377518
81MP0005025_abnormal_response_to0.90694599
82MP0000537_abnormal_urethra_morphology0.89450847
83MP0001849_ear_inflammation0.88318809
84MP0009785_altered_susceptibility_to0.87718339
85MP0005621_abnormal_cell_physiology0.85319138
86MP0003453_abnormal_keratinocyte_physiol0.85299912
87MP0009379_abnormal_foot_pigmentation0.83125321
88MP0005384_cellular_phenotype0.83108929
89MP0000716_abnormal_immune_system0.82637345
90MP0009053_abnormal_anal_canal0.82244226
91MP0004133_heterotaxia0.82137906
92MP0009672_abnormal_birth_weight0.81558458
93MP0004947_skin_inflammation0.79638578
94MP0008260_abnormal_autophagy0.77839996
95MP0000358_abnormal_cell_content/0.77774054
96MP0000685_abnormal_immune_system0.76192403
97MP0000678_abnormal_parathyroid_gland0.75072869
98MP0002111_abnormal_tail_morphology0.75019663
99MP0009703_decreased_birth_body0.74096988
100MP0002405_respiratory_system_inflammati0.73623484
101MP0003221_abnormal_cardiomyocyte_apopto0.73340499
102MP0003806_abnormal_nucleotide_metabolis0.73018578
103MP0003315_abnormal_perineum_morphology0.72386112
104MP0001119_abnormal_female_reproductive0.72000526
105MP0001800_abnormal_humoral_immune0.71813506
106MP0000477_abnormal_intestine_morphology0.71734431
107MP0002877_abnormal_melanocyte_morpholog0.70643785
108MP0004264_abnormal_extraembryonic_tissu0.70142778
109MP0000733_abnormal_muscle_development0.69593484
110MP0009840_abnormal_foam_cell0.69442161
111MP0002419_abnormal_innate_immunity0.68527396
112MP0001853_heart_inflammation0.67354783
113MP0008770_decreased_survivor_rate0.64930186
114MP0003448_altered_tumor_morphology0.64482380
115MP0001881_abnormal_mammary_gland0.64041492
116MP0002925_abnormal_cardiovascular_devel0.63023865
117MP0002452_abnormal_antigen_presenting0.62993646
118MP0002420_abnormal_adaptive_immunity0.62652872
119MP0002092_abnormal_eye_morphology0.62134104
120MP0001819_abnormal_immune_cell0.61566493
121MP0000428_abnormal_craniofacial_morphol0.61044707
122MP0006036_abnormal_mitochondrial_physio0.60552581
123MP0002089_abnormal_postnatal_growth/wei0.60327206
124MP0002132_abnormal_respiratory_system0.60068609
125MP0006292_abnormal_olfactory_placode0.58222256
126MP0001835_abnormal_antigen_presentation0.54717494
127MP0005501_abnormal_skin_physiology0.54567671
128MP0005174_abnormal_tail_pigmentation0.54104297
129MP0003698_abnormal_male_reproductive0.53689694
130MP0003937_abnormal_limbs/digits/tail_de0.52860232
131MP0002160_abnormal_reproductive_system0.52202348
132MP0003699_abnormal_female_reproductive0.51977848

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.35968264
2Reticulocytopenia (HP:0001896)3.98452036
3Progressive muscle weakness (HP:0003323)3.89254544
4Abnormality of cells of the erythroid lineage (HP:0012130)3.69645572
5Selective tooth agenesis (HP:0001592)3.58766712
6Chromsome breakage (HP:0040012)3.58196825
7Ependymoma (HP:0002888)3.56101528
8Abnormal number of erythroid precursors (HP:0012131)3.53987397
9Colon cancer (HP:0003003)3.47199366
10Medulloblastoma (HP:0002885)3.32396242
11Breast hypoplasia (HP:0003187)3.30948419
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.29754513
13Oral leukoplakia (HP:0002745)3.19346581
14Patellar aplasia (HP:0006443)3.13904567
15Microvesicular hepatic steatosis (HP:0001414)3.02674482
16Aplastic anemia (HP:0001915)2.96990767
17Agnosia (HP:0010524)2.91541659
18Aplasia/Hypoplasia of the patella (HP:0006498)2.90539436
19Myelodysplasia (HP:0002863)2.81090740
20Abnormality of chromosome stability (HP:0003220)2.79739005
21Abnormality of the anterior horn cell (HP:0006802)2.79006284
22Degeneration of anterior horn cells (HP:0002398)2.79006284
23Ragged-red muscle fibers (HP:0003200)2.76492535
24Basal cell carcinoma (HP:0002671)2.75351922
25Absent thumb (HP:0009777)2.73865582
26Meckel diverticulum (HP:0002245)2.73707099
27Abnormality of the ileum (HP:0001549)2.69336578
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.64109800
29Abnormality of the preputium (HP:0100587)2.63023686
30Carpal bone hypoplasia (HP:0001498)2.60083453
31Rhabdomyosarcoma (HP:0002859)2.60000870
32Thrombocytosis (HP:0001894)2.58485693
33Progressive external ophthalmoplegia (HP:0000590)2.53702602
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.53349935
35Increased nuchal translucency (HP:0010880)2.51235218
36Pallor (HP:0000980)2.50713700
37Abnormal number of incisors (HP:0011064)2.48820395
38Proximal placement of thumb (HP:0009623)2.46086067
39Absent radius (HP:0003974)2.38537801
40Deviation of the thumb (HP:0009603)2.38398582
41Neoplasm of the pancreas (HP:0002894)2.36750896
42Rough bone trabeculation (HP:0100670)2.36650341
43Duodenal stenosis (HP:0100867)2.36643662
44Small intestinal stenosis (HP:0012848)2.36643662
45Abnormal trabecular bone morphology (HP:0100671)2.35774132
46Multiple enchondromatosis (HP:0005701)2.35625153
47High anterior hairline (HP:0009890)2.33243416
48Squamous cell carcinoma (HP:0002860)2.32234012
49Neoplasm of the oral cavity (HP:0100649)2.32152017
50Broad distal phalanx of finger (HP:0009836)2.31216068
51Prominent nose (HP:0000448)2.30875743
52IgA deficiency (HP:0002720)2.28996635
53Macrocytic anemia (HP:0001972)2.28682415
54Trismus (HP:0000211)2.26772563
55Astrocytoma (HP:0009592)2.26202889
56Abnormality of the astrocytes (HP:0100707)2.26202889
57Atresia of the external auditory canal (HP:0000413)2.25758613
58Impulsivity (HP:0100710)2.24988915
5911 pairs of ribs (HP:0000878)2.24402370
60High pitched voice (HP:0001620)2.23388914
61Recurrent viral infections (HP:0004429)2.22308774
62Tracheoesophageal fistula (HP:0002575)2.22207544
63Missing ribs (HP:0000921)2.21435476
64Aplasia involving forearm bones (HP:0009822)2.19848869
65Absent forearm bone (HP:0003953)2.19848869
66Urethral obstruction (HP:0000796)2.19000130
67Cholecystitis (HP:0001082)2.18175472
68Abnormal gallbladder physiology (HP:0012438)2.18175472
69Facial hemangioma (HP:0000329)2.16027396
70Ectopic kidney (HP:0000086)2.15567860
71Neoplasm of striated muscle (HP:0009728)2.15439655
72Bone marrow hypocellularity (HP:0005528)2.15397882
73Abnormality of DNA repair (HP:0003254)2.15069880
74Sloping forehead (HP:0000340)2.14736618
75Hypertensive crisis (HP:0100735)2.14329806
76Deep palmar crease (HP:0006191)2.13672624
77Premature ovarian failure (HP:0008209)2.13196989
78Overlapping toe (HP:0001845)2.12127394
79Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.12011553
80Short 4th metacarpal (HP:0010044)2.12011553
81Pancytopenia (HP:0001876)2.11842716
82Abnormality of the carotid arteries (HP:0005344)2.10791158
83Overriding aorta (HP:0002623)2.10538028
84Insomnia (HP:0100785)2.09502911
85Slender long bone (HP:0003100)2.06874348
86Amaurosis fugax (HP:0100576)2.04928281
87Abnormality of abdominal situs (HP:0011620)2.04693127
88Abdominal situs inversus (HP:0003363)2.04693127
89Abnormality of the labia minora (HP:0012880)2.04176459
90Premature graying of hair (HP:0002216)2.03626381
91Cafe-au-lait spot (HP:0000957)2.03161935
92Ureteral duplication (HP:0000073)2.03003306
93Microretrognathia (HP:0000308)2.02166365
94Optic nerve coloboma (HP:0000588)2.00990130
95Long palpebral fissure (HP:0000637)2.00635718
96Volvulus (HP:0002580)2.00282764
97Hypergonadotropic hypogonadism (HP:0000815)1.98940245
98Aplasia/Hypoplasia of the thymus (HP:0010515)1.97410513
99Supernumerary spleens (HP:0009799)1.95529700
100Abnormality of the duodenum (HP:0002246)1.94465949
101Cerebral hypomyelination (HP:0006808)1.94435969
102Abnormality of the fingertips (HP:0001211)1.94318705
103Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94038025
104Short thumb (HP:0009778)1.93473112
105Homocystinuria (HP:0002156)1.93062825
106Abnormality of homocysteine metabolism (HP:0010919)1.93062825
107Duplication of thumb phalanx (HP:0009942)1.92833169
108Cellular immunodeficiency (HP:0005374)1.92386592
109Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91576939
110Glioma (HP:0009733)1.91153562
111Rib fusion (HP:0000902)1.90796236
112Elfin facies (HP:0004428)1.90235232
113Lymphoma (HP:0002665)1.87897756
114Abnormality of the calcaneus (HP:0008364)1.87114988
115Acute lymphatic leukemia (HP:0006721)1.86149337
116Abnormal lung lobation (HP:0002101)1.85962376
117Cortical dysplasia (HP:0002539)1.85956763
118Abnormality of reticulocytes (HP:0004312)1.84258818
119Dysphonia (HP:0001618)1.83495134
120Poikiloderma (HP:0001029)1.82248635
121Thoracic kyphosis (HP:0002942)1.81448191
122Aplasia/hypoplasia of the humerus (HP:0006507)1.81257290
123Testicular atrophy (HP:0000029)1.79802479
124Cleft eyelid (HP:0000625)1.78952208
125Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77926238
126Hyperacusis (HP:0010780)1.77809267
127Horseshoe kidney (HP:0000085)1.77403489
128IgM deficiency (HP:0002850)1.77045561
129Triphalangeal thumb (HP:0001199)1.75974480
130Long eyelashes (HP:0000527)1.75176696
131Aplasia/Hypoplasia of the sternum (HP:0006714)1.74966254
132Self-mutilation (HP:0000742)1.74092032
133Trigonocephaly (HP:0000243)1.73246845
134Atrophy/Degeneration involving motor neurons (HP:0007373)1.72492688
135Leukopenia (HP:0001882)1.69908408
136Impaired proprioception (HP:0010831)1.68487826
137Duplicated collecting system (HP:0000081)1.68103371
138Choanal atresia (HP:0000453)1.66268508
139Respiratory difficulties (HP:0002880)1.65387199
140Entropion (HP:0000621)1.61117698
141Abnormality of pyrimidine metabolism (HP:0004353)1.60559515
142Abnormality of lateral ventricle (HP:0030047)1.60119565

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.58920029
2SMG14.08953977
3WEE13.78494406
4BUB13.66939441
5VRK23.54101423
6EEF2K3.14343281
7NEK23.10003423
8IRAK32.79301140
9CDK122.52106869
10EIF2AK12.50518434
11TTK2.38513244
12PRPF4B2.29838954
13NEK12.10149747
14RPS6KB22.08125997
15MAP3K102.01573797
16TESK21.95305302
17ACVR1B1.89293024
18PASK1.86940815
19CDK71.86728586
20STK101.83641179
21PLK11.82152775
22TSSK61.78259785
23TAF11.72263889
24PBK1.71192405
25ATR1.69508059
26PLK41.60024208
27SRPK11.59096485
28CDK41.58320359
29AURKB1.56373696
30RPS6KA41.55723178
31BRSK21.53936303
32MAP3K81.53194576
33SCYL21.49294877
34DYRK31.48445572
35PKN21.43771979
36NME21.42936404
37CHEK21.40900977
38PAK41.34500370
39NME11.34462034
40SIK11.32803941
41CHEK11.29327356
42MAP4K11.25530980
43VRK11.22040382
44MKNK11.21323265
45MAPKAPK31.20121880
46SIK21.17083322
47PIM11.15718815
48TGFBR11.14916984
49FLT31.14836858
50EPHA21.12769092
51LRRK21.12762311
52TRIB31.11920420
53STK41.10475988
54AURKA1.09544299
55CAMK1D1.07167485
56TLK11.04013660
57EIF2AK31.03957964
58MAP3K141.03156223
59PIM21.02044286
60ERN11.02003744
61BRSK11.01043832
62TESK10.98185895
63PLK30.97698348
64CDK20.90984349
65ALK0.88540583
66LATS20.87527943
67ATM0.86927270
68CDK60.85893231
69MAP2K30.85530227
70MAP3K110.76583068
71MKNK20.75940123
72ZAK0.74737625
73CCNB10.72305173
74MTOR0.72090435
75STK30.71544881
76ICK0.71105112
77PAK10.70085187
78CDK80.68295320
79FGFR40.68223765
80MELK0.67345987
81BRD40.66924610
82KDR0.60163195
83DAPK10.59932852
84TAOK10.59730620
85CSNK2A20.59190449
86GRK60.59150511
87CDK10.58388615
88BTK0.58007976
89MATK0.54917918
90ARAF0.54646989
91JAK30.51489657
92BCKDK0.51352102
93CSNK2A10.51276791
94IKBKB0.50312070
95EIF2AK20.50110921
96PRKCI0.49897251
97RAF10.48834682
98STK160.48748878
99TBK10.46552265
100IRAK20.46299322
101HIPK20.45794848
102CSF1R0.45579967
103MAP3K130.45193344
104ZAP700.42638461
105TYK20.42387249
106PAK20.42180129
107CDC42BPA0.42083203
108CLK10.41597155
109IRAK40.39970178
110CAMK1G0.37912067
111RIPK40.37150306
112LATS10.36679809
113KIT0.36235546
114SIK30.36196355
115CDK11A0.35707002
116AKT20.35661070
117TYRO30.35313349
118ILK0.34771864
119MAPK110.33311543
120BMX0.32921488
121PDK40.32097530
122PDK30.32097530
123RPS6KA50.31844431
124MAPKAPK20.31683639
125TAOK20.31566980
126CSNK1E0.31425329
127MAP3K60.31237272
128CDK90.29896461
129PRKDC0.28533910
130PNCK0.27645871
131MAPK140.27253113
132CHUK0.27046775
133BRAF0.26987629

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.29365054
2Mismatch repair_Homo sapiens_hsa034304.42987357
3Base excision repair_Homo sapiens_hsa034103.25340610
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.23193470
5Spliceosome_Homo sapiens_hsa030403.13375222
6Homologous recombination_Homo sapiens_hsa034403.01966427
7* RNA transport_Homo sapiens_hsa030132.98560929
8Cell cycle_Homo sapiens_hsa041102.93316946
9Ribosome_Homo sapiens_hsa030102.91129428
10Nucleotide excision repair_Homo sapiens_hsa034202.87210213
11One carbon pool by folate_Homo sapiens_hsa006702.69901444
12RNA polymerase_Homo sapiens_hsa030202.38862898
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.29478478
14Proteasome_Homo sapiens_hsa030502.27845907
15Pyrimidine metabolism_Homo sapiens_hsa002402.10561145
16Fanconi anemia pathway_Homo sapiens_hsa034602.09588483
17Non-homologous end-joining_Homo sapiens_hsa034501.92706413
18RNA degradation_Homo sapiens_hsa030181.91644923
19mRNA surveillance pathway_Homo sapiens_hsa030151.76584285
20p53 signaling pathway_Homo sapiens_hsa041151.76080860
21Basal transcription factors_Homo sapiens_hsa030221.73731478
22Epstein-Barr virus infection_Homo sapiens_hsa051691.22450074
23Viral carcinogenesis_Homo sapiens_hsa052031.14017910
24Herpes simplex infection_Homo sapiens_hsa051681.12502625
25Antigen processing and presentation_Homo sapiens_hsa046121.11524476
26Systemic lupus erythematosus_Homo sapiens_hsa053221.00574697
27Purine metabolism_Homo sapiens_hsa002300.99125035
28Oocyte meiosis_Homo sapiens_hsa041140.98135250
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96169969
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96140420
31HTLV-I infection_Homo sapiens_hsa051660.95805095
32Pentose phosphate pathway_Homo sapiens_hsa000300.90456472
33Biosynthesis of amino acids_Homo sapiens_hsa012300.90039249
34Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89726501
35Small cell lung cancer_Homo sapiens_hsa052220.86479102
36MicroRNAs in cancer_Homo sapiens_hsa052060.85898649
37Other glycan degradation_Homo sapiens_hsa005110.84679910
38Intestinal immune network for IgA production_Homo sapiens_hsa046720.84601594
39Thyroid cancer_Homo sapiens_hsa052160.84473301
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83058159
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.80599633
42Selenocompound metabolism_Homo sapiens_hsa004500.76567898
43Primary immunodeficiency_Homo sapiens_hsa053400.76257946
44Legionellosis_Homo sapiens_hsa051340.72966012
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72668779
46Chronic myeloid leukemia_Homo sapiens_hsa052200.72567001
47Sulfur relay system_Homo sapiens_hsa041220.72105419
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71740967
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.69925583
50Apoptosis_Homo sapiens_hsa042100.68922808
51Allograft rejection_Homo sapiens_hsa053300.68885876
52Colorectal cancer_Homo sapiens_hsa052100.67763443
53Shigellosis_Homo sapiens_hsa051310.65659743
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64449027
55Huntingtons disease_Homo sapiens_hsa050160.64249952
56Notch signaling pathway_Homo sapiens_hsa043300.63291624
57Parkinsons disease_Homo sapiens_hsa050120.63122403
58Hepatitis B_Homo sapiens_hsa051610.58951148
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58158618
60Acute myeloid leukemia_Homo sapiens_hsa052210.57453832
61Measles_Homo sapiens_hsa051620.56576357
62Oxidative phosphorylation_Homo sapiens_hsa001900.56413332
63Folate biosynthesis_Homo sapiens_hsa007900.56015328
64Bladder cancer_Homo sapiens_hsa052190.55329522
65Autoimmune thyroid disease_Homo sapiens_hsa053200.52132857
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.52020027
67Asthma_Homo sapiens_hsa053100.50126368
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50058821
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.49530141
70TGF-beta signaling pathway_Homo sapiens_hsa043500.49520421
71Basal cell carcinoma_Homo sapiens_hsa052170.49019000
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48675988
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48594862
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48554162
75Hippo signaling pathway_Homo sapiens_hsa043900.48236141
76Viral myocarditis_Homo sapiens_hsa054160.45375631
77TNF signaling pathway_Homo sapiens_hsa046680.45277726
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44275548
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.44021239
80Hepatitis C_Homo sapiens_hsa051600.43819450
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43422082
82N-Glycan biosynthesis_Homo sapiens_hsa005100.43210469
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42812282
84Influenza A_Homo sapiens_hsa051640.42065400
85mTOR signaling pathway_Homo sapiens_hsa041500.41404402
86Pancreatic cancer_Homo sapiens_hsa052120.41374200
87HIF-1 signaling pathway_Homo sapiens_hsa040660.41187413
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41034256
89B cell receptor signaling pathway_Homo sapiens_hsa046620.40441227
90Carbon metabolism_Homo sapiens_hsa012000.39763425
91Adherens junction_Homo sapiens_hsa045200.39722403
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39648085
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38848970
94Non-small cell lung cancer_Homo sapiens_hsa052230.38790824
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37542846
96Pathways in cancer_Homo sapiens_hsa052000.36580384
97Leishmaniasis_Homo sapiens_hsa051400.35397822
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35142917
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35123931
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35080824
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34872181
102Osteoclast differentiation_Homo sapiens_hsa043800.33133174
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32629213
104Lysine degradation_Homo sapiens_hsa003100.30939177
105Pyruvate metabolism_Homo sapiens_hsa006200.30481156
106Hematopoietic cell lineage_Homo sapiens_hsa046400.29719538
107Alcoholism_Homo sapiens_hsa050340.29648041
108Lysosome_Homo sapiens_hsa041420.28082127
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.25970655
110Fructose and mannose metabolism_Homo sapiens_hsa000510.25490923
111Prostate cancer_Homo sapiens_hsa052150.25134997
112Vitamin B6 metabolism_Homo sapiens_hsa007500.24841950
113Toxoplasmosis_Homo sapiens_hsa051450.24732854
114Hedgehog signaling pathway_Homo sapiens_hsa043400.24376536
115VEGF signaling pathway_Homo sapiens_hsa043700.23468792
116Glutathione metabolism_Homo sapiens_hsa004800.23132365
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21478358
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.20690022
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20438389
120Proteoglycans in cancer_Homo sapiens_hsa052050.19805159
121Endometrial cancer_Homo sapiens_hsa052130.19561253
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19109014
123Galactose metabolism_Homo sapiens_hsa000520.19069393

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